PedAM

Pediatric Disease Annotations & Medicines


	gallbladder disease

Disease ID	600
Disease	gallbladder disease
Definition	Diseases of the GALLBLADDER. They generally involve the impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, neoplasms, or other diseases.
Synonym	biliary disease biliary diseases bladder disease, gall bladder diseases, gall dis of gallbladder nos disease biliary disease gallbladder disease of gallbladder disease of gallbladder (disorder) disease of gallbladder, nos disease, gall bladder disease, gallbladder diseases, gall bladder diseases, gallbladder disorder of gallbladder disorder of gallbladder (disorder) gall bladder dis gall bladder disease gall bladder diseases gall bladder disorder gall bladder disorders nos gallbladder dis gallbladder diseases gallbladder diseases [disease/finding] gallbladder disorder gallbladder disorder, nos gallbladder disorders gallbladder disorders nos gallbladder disorders nos (disorder) gallbladder--diseases unspecified disorder of gallbladder
DOID	DOID:0060262
UMLS	C0016977
MeSH	D005705
SNOMED-CT	SNOMEDCT_US_2016_09_01:39621005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:14) C0008350 \| cholelithiasis \| 2 C0029408 \| osteoarthritis \| 1 C0005684 \| bladder cancer \| 1 C0007222 \| cardiovascular disease \| 1 C0153452 \| gallbladder ca \| 1 C0037661 \| somatostatinoma \| 1 C0008325 \| cholecystitis \| 1 C0011847 \| diabetes \| 1 C0153452 \| gallbladder cancer \| 1 C0028754 \| obesity \| 1 C0023895 \| liver disease \| 1 C0019322 \| umbilical hernia \| 1 C0008350 \| gallstone \| 1 C0042373 \| vascular disease \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:15) 91526 \| ANKRD44 \| infer 338 \| APOB \| infer 348 \| APOE \| infer 1803 \| DPP4 \| infer 8087 \| FXR1 \| infer 266722 \| HS6ST3 \| infer 8690 \| JRKL \| infer 359750 \| MRPL50P3 \| infer 50863 \| NTM \| infer 11122 \| PTPRT \| infer 5898 \| RALA \| infer 100271352 \| RPS12P16 \| infer 387495 \| RPS26P5 \| infer 6555 \| SLC10A2 \| infer 25769 \| SLC24A2 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:206) 1080 \| CFTR \| DISEASES 920 \| CD4 \| DISEASES 6344 \| SCTR \| DISEASES 634 \| CEACAM1 \| DISEASES 6343 \| SCT \| DISEASES 6793 \| STK10 \| DISEASES 4680 \| CEACAM6 \| DISEASES 1071 \| CETP \| DISEASES 26517 \| TIMM13 \| DISEASES 26499 \| PLEK2 \| DISEASES 1113 \| CHGA \| DISEASES 140679 \| SLC32A1 \| DISEASES 10857 \| PGRMC1 \| DISEASES 27344 \| PCSK1N \| DISEASES 479 \| ATP12A \| DISEASES 343 \| AQP8 \| DISEASES 27120 \| DKKL1 \| DISEASES 2091 \| FBL \| DISEASES 973 \| CD79A \| DISEASES 1048 \| CEACAM5 \| DISEASES 5919 \| RARRES2 \| DISEASES 5539 \| PPY \| DISEASES 6783 \| SULT1E1 \| DISEASES 3732 \| CD82 \| DISEASES 1075 \| CTSC \| DISEASES 3565 \| IL4 \| DISEASES 338 \| APOB \| DISEASES 335 \| APOA1 \| DISEASES 7276 \| TTR \| DISEASES 3007 \| HIST1H1D \| DISEASES 6555 \| SLC10A2 \| DISEASES 7355 \| SLC35A2 \| DISEASES 2678 \| GGT1 \| DISEASES 15 \| AANAT \| DISEASES 3630 \| INS \| DISEASES 348 \| APOE \| DISEASES 10343 \| PKDREJ \| DISEASES 9945 \| GFPT2 \| DISEASES 8431 \| NR0B2 \| DISEASES 57050 \| UTP3 \| DISEASES 6754 \| SSTR4 \| DISEASES 1401 \| CRP \| DISEASES 4678 \| NASP \| DISEASES 1131 \| CHRM3 \| DISEASES 4922 \| NTS \| DISEASES 10599 \| SLCO1B1 \| DISEASES 10677 \| AVIL \| DISEASES 80896 \| NPL \| DISEASES 1593 \| CYP27A1 \| DISEASES 3569 \| IL6 \| DISEASES 64240 \| ABCG5 \| DISEASES 949 \| SCARB1 \| DISEASES 114294 \| LACTB \| DISEASES 9340 \| GLP2R \| DISEASES 10483 \| SEC23B \| DISEASES 495 \| ATP4A \| DISEASES 5465 \| PPARA \| DISEASES 25939 \| SAMHD1 \| DISEASES 6929 \| TCF3 \| DISEASES 2549 \| GAB1 \| DISEASES 3553 \| IL1B \| DISEASES 8726 \| EED \| DISEASES 1991 \| ELANE \| DISEASES 4722 \| NDUFS3 \| DISEASES 8647 \| ABCB11 \| DISEASES 3299 \| HSF4 \| DISEASES 5443 \| POMC \| DISEASES 4547 \| MTTP \| DISEASES 5244 \| ABCB4 \| DISEASES 6713 \| SQLE \| DISEASES 11001 \| SLC27A2 \| DISEASES 64241 \| ABCG8 \| DISEASES 805 \| CALM2 \| DISEASES 167410 \| LIX1 \| DISEASES 91937 \| TIMD4 \| DISEASES 51302 \| CYP39A1 \| DISEASES 23196 \| FAM120A \| DISEASES 5741 \| PTH \| DISEASES 92935 \| MARS2 \| DISEASES 6326 \| SCN2A \| DISEASES 5205 \| ATP8B1 \| DISEASES 10750 \| GRAP \| DISEASES 4838 \| NODAL \| DISEASES 7547 \| ZIC3 \| DISEASES 6750 \| SST \| DISEASES 23420 \| NOMO1 \| DISEASES 3815 \| KIT \| DISEASES 808 \| CALM3 \| DISEASES 23387 \| SIK3 \| DISEASES 1990 \| CELA1 \| DISEASES 6755 \| SSTR5 \| DISEASES 9965 \| FGF19 \| DISEASES 10630 \| PDPN \| DISEASES 51072 \| MEMO1 \| DISEASES 886 \| CCKAR \| DISEASES 213 \| ALB \| DISEASES 7047 \| TGM4 \| DISEASES 200931 \| SLC51A \| DISEASES 4724 \| NDUFS4 \| DISEASES 6690 \| SPINK1 \| DISEASES 1581 \| CYP7A1 \| DISEASES 4255 \| MGMT \| DISEASES 3479 \| IGF1 \| DISEASES 54578 \| UGT1A6 \| DISEASES 5968 \| REG1B \| DISEASES 54658 \| UGT1A1 \| DISEASES 6579 \| SLCO1A2 \| DISEASES 83886 \| PRSS27 \| DISEASES 2147 \| F2 \| DISEASES 23209 \| MLC1 \| DISEASES 9420 \| CYP7B1 \| DISEASES 80227 \| PAAF1 \| DISEASES 3952 \| LEP \| DISEASES 2688 \| GH1 \| DISEASES 64755 \| C16orf58 \| DISEASES 55084 \| SOBP \| DISEASES 63951 \| DMRTA1 \| DISEASES 4018 \| LPA \| DISEASES 23212 \| RRS1 \| DISEASES 25915 \| NDUFAF3 \| DISEASES 3855 \| KRT7 \| DISEASES 3953 \| LEPR \| DISEASES 2520 \| GAST \| DISEASES 9939 \| RBM8A \| DISEASES 3043 \| HBB \| DISEASES 2152 \| F3 \| DISEASES 123264 \| SLC51B \| DISEASES 885 \| CCK \| DISEASES 9138 \| ARHGEF1 \| DISEASES 23436 \| CELA3B \| DISEASES 23583 \| SMUG1 \| DISEASES 51337 \| THEM6 \| DISEASES 7180 \| CRISP2 \| DISEASES 145264 \| SERPINA12 \| DISEASES 400673 \| VMAC \| DISEASES 54575 \| UGT1A10 \| DISEASES 5265 \| SERPINA1 \| DISEASES 3240 \| HP \| DISEASES 7405 \| UVRAG \| DISEASES 146059 \| CDAN1 \| DISEASES 4047 \| LSS \| DISEASES 801 \| CALM1 \| DISEASES 6752 \| SSTR2 \| DISEASES 26136 \| TES \| DISEASES 56980 \| PRDM10 \| DISEASES 5407 \| PNLIPRP1 \| DISEASES 1504 \| CTRB1 \| DISEASES 2673 \| GFPT1 \| DISEASES 56477 \| CCL28 \| DISEASES 58 \| ACTA1 \| DISEASES 5362 \| PLXNA2 \| DISEASES 7432 \| VIP \| DISEASES 2494 \| NR5A2 \| DISEASES 462 \| SERPINC1 \| DISEASES 336 \| APOA2 \| DISEASES 3068 \| HDGF \| DISEASES 6280 \| S100A9 \| DISEASES 9557 \| CHD1L \| DISEASES 2316 \| FLNA \| DISEASES 1244 \| ABCC2 \| DISEASES 959 \| CD40LG \| DISEASES 84293 \| FAM213A \| DISEASES 3633 \| INPP5B \| DISEASES 27095 \| TRAPPC3 \| DISEASES 7633 \| ZNF79 \| DISEASES 54576 \| UGT1A8 \| DISEASES 4146 \| MATN1 \| DISEASES 414189 \| AGAP6 \| DISEASES 3055 \| HCK \| DISEASES 5095 \| PCCA \| DISEASES 9356 \| SLC22A6 \| DISEASES 6303 \| SAT1 \| DISEASES 3045 \| HBD \| DISEASES 3030 \| HADHA \| DISEASES 1854 \| DUT \| DISEASES 3486 \| IGFBP3 \| DISEASES 438 \| ASMT \| DISEASES 283820 \| NOMO2 \| DISEASES 192668 \| CYS1 \| DISEASES 2235 \| FECH \| DISEASES 2172 \| FABP6 \| DISEASES 174 \| AFP \| DISEASES 408050 \| NOMO3 \| DISEASES 57708 \| MIER1 \| DISEASES 728441 \| GGT2 \| DISEASES 2641 \| GCG \| DISEASES 4295 \| MLN \| DISEASES 522 \| ATP5J \| DISEASES 119016 \| AGAP4 \| DISEASES 7124 \| TNF \| DISEASES 7866 \| IFRD2 \| DISEASES 642517 \| AGAP9 \| DISEASES 4588 \| MUC6 \| DISEASES 4583 \| MUC2 \| DISEASES 2859 \| GPR35 \| DISEASES 54659 \| UGT1A3 \| DISEASES 80012 \| PHC3 \| DISEASES 158219 \| TTC39B \| DISEASES 151306 \| GPBAR1 \| DISEASES 9404 \| LPXN \| DISEASES 4586 \| MUC5AC \| DISEASES 9971 \| NR1H4 \| DISEASES 84525 \| HOPX \| DISEASES 27229 \| TUBGCP4 \| DISEASES 57000 \| GSN-AS1 \| DISEASES 102723508 \| KANTR \| DISEASES
Locus	(Waiting for update.)

Disease ID	600
Disease	gallbladder disease
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:10) HP:0001081 \| Gallstones \| 2 HP:0001513 \| Obesity \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0001537 \| Umbilical hernias \| 1 HP:0003077 \| Hyperlipidemia \| 1 HP:0002758 \| Osteoarthritis \| 1 HP:0001082 \| Cholecystitis \| 1 HP:0002664 \| Neoplasia \| 1 HP:0100790 \| Hernia \| 1 HP:0009725 \| Bladder neoplasm \| 1

Disease ID	600
Disease	gallbladder disease
Manually Symptom	UMLS \| Name(Total Manually Symptoms:4) C2598155 \| pain C1963198 \| pancreatitis C0422833 \| ent symptoms C0162871 \| abdominal aortic aneurysm
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:13)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
2	162916413	rs10490422	G	T	rs10490422	pha001404	5.92E-18	phs000007	phs000342	0.09	[0.07-0.11] unit increase	NA	ALL(0)	ALL(0)	Gallbladder disease	HPOID:0012438	Abnormal gallbladder physiology	DOID:0000000	gallbladder disease	NA	NA	NA	NA	Gallbladder disease	rs10490422-C	NA	G	DPP4	intron
2	198032683	rs6725302	A	G	rs6725302	pha001404	1.73E-15	phs000007	phs000342	0.09	[0.07-0.11] unit decrease	NA	ALL(0)	ALL(0)	Gallbladder disease	HPOID:0012438	Abnormal gallbladder physiology	DOID:0000000	gallbladder disease	NA	NA	NA	NA	Gallbladder disease	rs6725302-T	NA	G	ANKRD44	intron
3	180691092	rs1010471	G	A	rs1010471	pha001403	8.11E-05	phs000007	phs000342	-3.941(FBAT)	[NR]	NA	ALL(0)	ALL(0)	Gallbladder disease	HPOID:0012438	Abnormal gallbladder physiology	DOID:0000000	gallbladder disease	NA	NA	NA	NA	Gallbladder disease	rs1010471-T	NA	A	FXR1	intron
5	178028356	rs7717346	T	C	rs7717346	pha001404	6.47E-15	phs000007	phs000342	0.11	[0.08-0.14] unit increase	NA	ALL(0)	ALL(0)	Gallbladder disease	HPOID:0012438	Abnormal gallbladder physiology	DOID:0000000	gallbladder disease	NA	NA	NA	NA	Gallbladder disease	rs7717346-T	NA	T	NA	NA
7	39747905	rs10486804	G	A	rs10486804	pha001404	1.37E-15	phs000007	phs000342	0.11	[0.08-0.14] unit increase	NA	ALL(0)	ALL(0)	Gallbladder disease	HPOID:0012438	Abnormal gallbladder physiology	DOID:0000000	gallbladder disease	NA	NA	NA	NA	Gallbladder disease	rs10486804-G	NA	G	NA	NA
9	20308166	rs7851959	G	C	rs7851959	pha001404	1.25E-15	phs000007	phs000342	0.11	[0.08-0.14] unit increase	NA	ALL(0)	ALL(0)	Gallbladder disease	HPOID:0012438	Abnormal gallbladder physiology	DOID:0000000	gallbladder disease	NA	NA	NA	NA	Gallbladder disease	rs7851959-G	NA	G	NA	NA
10	35165095	rs11010007	G	A	rs11010007	pha001404	9.75E-15	phs000007	phs000342	0.11	[0.08-0.14] unit decrease	NA	ALL(0)	ALL(0)	Gallbladder disease	HPOID:0012438	Abnormal gallbladder physiology	DOID:0000000	gallbladder disease	NA	NA	NA	NA	Gallbladder disease	rs11010007-T	NA	G	NA	NA
11	98596131	rs3858427	C	T	rs3858427	pha001404	6.02E-15	phs000007	phs000342	0.12	[0.09-0.15] unit decrease	NA	ALL(0)	ALL(0)	Gallbladder disease	HPOID:0012438	Abnormal gallbladder physiology	DOID:0000000	gallbladder disease	NA	NA	NA	NA	Gallbladder disease	rs3858427-T	NA	C	NA	NA
11	131854850	rs585904	T	G	rs585904	pha001404	4.57E-16	phs000007	phs000342	0.11	[0.08-0.14] unit increase	NA	ALL(0)	ALL(0)	Gallbladder disease	HPOID:0012438	Abnormal gallbladder physiology	DOID:0000000	gallbladder disease	NA	NA	NA	NA	Gallbladder disease	rs585904-C	NA	C	NTM	intron
13	96860923	rs10492589	A	T	rs10492589	pha001404	1.22E-14	phs000007	phs000342	0.09	[0.07-0.11] unit increase	NA	ALL(0)	ALL(0)	Gallbladder disease	HPOID:0012438	Abnormal gallbladder physiology	DOID:0000000	gallbladder disease	NA	NA	NA	NA	Gallbladder disease	rs10492589-T	NA	T	HS6ST3	intron
13	103978779	rs3918334	T	G	rs3918334	pha001403	4.76E-05	phs000007	phs000342	-4.067(FBAT)	[NR]	NA	ALL(0)	ALL(0)	Gallbladder disease	HPOID:0012438	Abnormal gallbladder physiology	DOID:0000000	gallbladder disease	NA	NA	NA	NA	Gallbladder disease	rs3918334-C	NA	T	NA	NA
20	41003185	rs1015385	C	A	rs1015385	pha001403	1.50E-05	phs000007	phs000342	4.328(FBAT)	[NR]	NA	ALL(0)	ALL(0)	Gallbladder disease	HPOID:0012438	Abnormal gallbladder physiology	DOID:0000000	gallbladder disease	NA	NA	NA	NA	Gallbladder disease	rs1015385-C	NA	A	PTPRT	intron
21	18814425	rs1389158	A	G	rs1389158	pha001404	6.34E-17	phs000007	phs000342	0.11	[0.08-0.14] unit increase	NA	ALL(0)	ALL(0)	Gallbladder disease	HPOID:0012438	Abnormal gallbladder physiology	DOID:0000000	gallbladder disease	NA	NA	NA	NA	Gallbladder disease	rs1389158-T	NA	A	C21orf37	intron

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:6)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0016977	s-adenosylmethionine	D012436	29908-03-0	gallbladder diseases	MESH:D005705	therapeutic	18518811
C0016977	colchicine	D003078	64-86-8	gallbladder diseases	MESH:D005705	marker/mechanism	3733464
C0016977	lanreotide	C060347	118992-92-0	gallbladder diseases	MESH:D005705	marker/mechanism	10601961
C0016977	octreotide	D015282	83150-76-9	gallbladder diseases	MESH:D005705	marker/mechanism	10601961
C0016977	progesterone	D011374	57-83-0	gallbladder diseases	MESH:D005705	marker/mechanism	16034922
C0016977	streptozocin	D013311	18883-66-4	gallbladder diseases	MESH:D005705	marker/mechanism	15384252

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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