PedAM

Pediatric Disease Annotations & Medicines


	focal segmental glomerulosclerosis

Disease ID	333
Disease	focal segmental glomerulosclerosis
Definition	A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.
Synonym	fgs (focal glomerular sclerosis) fgs - focal glomerulosclerosis focal and segmental glomerular sclerosis focal and segmental glomerulosclerosis focal glomerular sclerosis focal glomerular sclerosis (disorder) focal glomerulosclerosis focal sclerosing glomerulonephritides focal sclerosing glomerulonephritis focal segmental glomerulosclerosis (disorder) focal segmental glomerulosclerosis (fsgs) fsgs fsgs - focal segmental glomerulosclerosis glomerulonephritides, focal sclerosing glomerulonephritis, focal sclerosing glomerulosclerosis, focal glomerulosclerosis, focal segmental glomerulosclerosis, focal segmental [disease/finding] hyalinosis, focal sclerosing glomerulonephritides, focal sclerosing glomerulonephritis, focal segmental glomerulosclerosis, focal
DOID	DOID:1312
UMLS	C0017668
MeSH	D005923
SNOMED-CT	SNOMEDCT_US_2016_09_01:25821008;SNOMEDCT_US_2016_09_01:236403004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:63) C0027726 \| nephrotic syndrome \| 20 C0033687 \| proteinuria \| 14 C0022658 \| renal disease \| 11 C0022661 \| end-stage renal disease \| 7 C0022658 \| nephropathy \| 6 C0022658 \| kidney disease \| 5 C0035078 \| renal failure \| 5 C0027697 \| nephritis \| 4 C0017658 \| glomerulonephritis \| 4 C0020538 \| hypertension \| 4 C0027707 \| interstitial nephritis \| 3 C0022521 \| kartagener syndrome \| 2 C0022661 \| end-stage kidney disease \| 2 C0001175 \| acquired immunodeficiency syndrome \| 1 C0376545 \| hematological malignancies \| 1 C0403416 \| crescentic glomerulonephritis \| 1 C0011881 \| diabetic nephropathy \| 1 C0036323 \| schistosomiasis \| 1 C0036319 \| schistosoma mansoni \| 1 C0022667 \| papillary necrosis \| 1 C0008312 \| biliary cirrhosis \| 1 C0393819 \| chronic inflammatory demyelinating polyneuropathy \| 1 C0008728 \| churg-strauss syndrome \| 1 C0026764 \| myeloma \| 1 C0023434 \| chronic lymphocytic leukaemia \| 1 C0334634 \| mantle cell lymphoma \| 1 C0235618 \| proliferative glomerulonephritis \| 1 C0268450 \| gitelman syndrome \| 1 C0003873 \| rheumatoid arthritis \| 1 C0278846 \| invasive thymoma \| 1 C0032461 \| polycythemia \| 1 C0085113 \| neurofibromatosis \| 1 C0152013 \| lung adenocarcinoma \| 1 C0026764 \| multiple myeloma \| 1 C0085580 \| essential hypertension \| 1 C0041349 \| tubulointerstitial nephritis \| 1 C0023448 \| lymphocytic leukaemia \| 1 C0023418 \| leukaemia \| 1 C0178664 \| glomerulosclerosis \| 1 C0017661 \| iga nephropathy \| 1 C0011847 \| diabetes \| 1 C0008312 \| primary biliary cirrhosis \| 1 C0022661 \| end stage renal disease \| 1 C0001175 \| acquired immunodeficiency syndrome (aids) \| 1 C0270922 \| demyelinating polyneuropathy \| 1 C0017665 \| membranous nephropathy \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0022661 \| chronic kidney disease \| 1 C0027720 \| nephrosis \| 1 C0152025 \| polyneuropathy \| 1 C0001815 \| idiopathic myelofibrosis \| 1 C0024214 \| lymphangiectasia \| 1 C0007959 \| charcot-marie-tooth disease \| 1 C0403447 \| chronic renal insufficiency \| 1 C0022660 \| acute renal failure \| 1 C0409974 \| lupus erythematosus \| 1 C1565489 \| renal insufficiency \| 1 C1527336 \| sjogren's syndrome \| 1 C0342388 \| acth deficiency \| 1 C0221238 \| mesangial proliferative glomerulonephritis \| 1 C0553662 \| juvenile rheumatoid arthritis \| 1 C0028754 \| obesity \| 1 C0003864 \| arthritis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:22) TGFB1 \| 7040 \| CTD_human COL4A1 \| 1282 \| CTD_human MPV17 \| 4358 \| CTD_human EDN1 \| 1906 \| CTD_human PCNA \| 5111 \| CTD_human NOS2 \| 4843 \| CTD_human AGT \| 183 \| CTD_human NPHS2 \| 7827 \| CTD_human MYH9 \| 4627 \| CTD_human SPP1 \| 6696 \| CTD_human NPHS1 \| 4868 \| CTD_human ACTA2 \| 59 \| CTD_human ACTN4 \| 81 \| CLINVAR;CTD_human CTGF \| 1490 \| CTD_human INF2 \| 64423 \| CTD_human SERPINE1 \| 5054 \| CTD_human MYH10 \| 4628 \| CTD_human ZMPSTE24 \| 10269 \| CTD_human CD2AP \| 23607 \| CTD_human FN1 \| 2335 \| CTD_human GNAQ \| 2776 \| CTD_human HAVCR1 \| 26762 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:7) 5444 \| PON1 \| infer 7490 \| WT1 \| infer 81 \| ACTN4 \| infer 8542 \| APOL1 \| infer 2028 \| ENPEP \| infer 51196 \| PLCE1 \| infer 7225 \| TRPC6 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:216) 282706 \| DAOA-AS1 \| DISEASES 4282 \| MIF \| DISEASES 4627 \| MYH9 \| DISEASES 7076 \| TIMP1 \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 5444 \| PON1 \| DISEASES 5054 \| SERPINE1 \| DISEASES 6347 \| CCL2 \| DISEASES 7448 \| VTN \| DISEASES 3558 \| IL2 \| DISEASES 1027 \| CDKN1B \| DISEASES 57122 \| NUP107 \| DISEASES 1839 \| HBEGF \| DISEASES 64902 \| AGXT2 \| DISEASES 2908 \| NR3C1 \| DISEASES 1894 \| ECT2 \| DISEASES 4358 \| MPV17 \| DISEASES 7276 \| TTR \| DISEASES 7043 \| TGFB3 \| DISEASES 5217 \| PFN2 \| DISEASES 27019 \| DNAI1 \| DISEASES 79809 \| TTC21B \| DISEASES 718 \| C3 \| DISEASES 10047 \| CST8 \| DISEASES 6629 \| SNRPB2 \| DISEASES 23780 \| APOL2 \| DISEASES 968 \| CD68 \| DISEASES 5894 \| RAF1 \| DISEASES 348 \| APOE \| DISEASES 59272 \| ACE2 \| DISEASES 81 \| ACTN4 \| DISEASES 10343 \| PKDREJ \| DISEASES 9590 \| AKAP12 \| DISEASES 4608 \| MYBPH \| DISEASES 81494 \| CFHR5 \| DISEASES 8728 \| ADAM19 \| DISEASES 2799 \| GNS \| DISEASES 3569 \| IL6 \| DISEASES 84681 \| HINT2 \| DISEASES 27283 \| TINAG \| DISEASES 51196 \| PLCE1 \| DISEASES 1295 \| COL8A1 \| DISEASES 4069 \| LYZ \| DISEASES 55746 \| NUP133 \| DISEASES 59341 \| TRPV4 \| DISEASES 4092 \| SMAD7 \| DISEASES 4087 \| SMAD2 \| DISEASES 7077 \| TIMP2 \| DISEASES 10552 \| ARPC1A \| DISEASES 23523 \| CABIN1 \| DISEASES 3553 \| IL1B \| DISEASES 57669 \| EPB41L5 \| DISEASES 4036 \| LRP2 \| DISEASES 941 \| CD80 \| DISEASES 2247 \| FGF2 \| DISEASES 5443 \| POMC \| DISEASES 3383 \| ICAM1 \| DISEASES 950 \| SCARB2 \| DISEASES 306 \| ANXA3 \| DISEASES 1004 \| CDH6 \| DISEASES 1950 \| EGF \| DISEASES 54443 \| ANLN \| DISEASES 6595 \| SMARCA2 \| DISEASES 3700 \| ITIH4 \| DISEASES 8826 \| IQGAP1 \| DISEASES 6687 \| SPG7 \| DISEASES 4628 \| MYH10 \| DISEASES 126374 \| WTIP \| DISEASES 5972 \| REN \| DISEASES 185 \| AGTR1 \| DISEASES 3934 \| LCN2 \| DISEASES 4851 \| NOTCH1 \| DISEASES 5800 \| PTPRO \| DISEASES 130271 \| PLEKHH2 \| DISEASES 22925 \| PLA2R1 \| DISEASES 8526 \| DGKE \| DISEASES 4643 \| MYO1E \| DISEASES 4690 \| NCK1 \| DISEASES 5909 \| RAP1GAP \| DISEASES 1636 \| ACE \| DISEASES 6352 \| CCL5 \| DISEASES 3856 \| KRT8 \| DISEASES 115 \| ADCY9 \| DISEASES 213 \| ALB \| DISEASES 57619 \| SHROOM3 \| DISEASES 28999 \| KLF15 \| DISEASES 84889 \| SLC7A3 \| DISEASES 3611 \| ILK \| DISEASES 93659 \| CGB5 \| DISEASES 51129 \| ANGPTL4 \| DISEASES 10736 \| SIX2 \| DISEASES 4330 \| MN1 \| DISEASES 7369 \| UMOD \| DISEASES 6383 \| SDC2 \| DISEASES 10238 \| DCAF7 \| DISEASES 23529 \| CLCF1 \| DISEASES 27235 \| COQ2 \| DISEASES 4118 \| MAL \| DISEASES 9844 \| ELMO1 \| DISEASES 64236 \| PDLIM2 \| DISEASES 998 \| CDC42 \| DISEASES 1191 \| CLU \| DISEASES 10458 \| BAIAP2 \| DISEASES 8542 \| APOL1 \| DISEASES 27319 \| BHLHE22 \| DISEASES 51715 \| RAB23 \| DISEASES 8727 \| CTNNAL1 \| DISEASES 3321 \| IGSF3 \| DISEASES 1730 \| DIAPH2 \| DISEASES 5032 \| P2RY11 \| DISEASES 1453 \| CSNK1D \| DISEASES 4772 \| NFATC1 \| DISEASES 7490 \| WT1 \| DISEASES 1287 \| COL4A5 \| DISEASES 4088 \| SMAD3 \| DISEASES 6297 \| SALL2 \| DISEASES 51004 \| COQ6 \| DISEASES 342184 \| FMN1 \| DISEASES 153571 \| C5orf38 \| DISEASES 10881 \| ACTL7A \| DISEASES 7430 \| EZR \| DISEASES 5329 \| PLAUR \| DISEASES 1180 \| CLCN1 \| DISEASES 7225 \| TRPC6 \| DISEASES 5962 \| RDX \| DISEASES 5498 \| PPOX \| DISEASES 1499 \| CTNNB1 \| DISEASES 26762 \| HAVCR1 \| DISEASES 4010 \| LMX1B \| DISEASES 7328 \| UBE2H \| DISEASES 5265 \| SERPINA1 \| DISEASES 92359 \| CRB3 \| DISEASES 50485 \| SMARCAL1 \| DISEASES 23556 \| PIGN \| DISEASES 55243 \| KIRREL \| DISEASES 23607 \| CD2AP \| DISEASES 84063 \| KIRREL2 \| DISEASES 8828 \| NRP2 \| DISEASES 4311 \| MME \| DISEASES 10724 \| MGEA5 \| DISEASES 88 \| ACTN2 \| DISEASES 183 \| AGT \| DISEASES 1378 \| CR1 \| DISEASES 5788 \| PTPRC \| DISEASES 7827 \| NPHS2 \| DISEASES 1490 \| CTGF \| DISEASES 10763 \| NES \| DISEASES 57107 \| PDSS2 \| DISEASES 128344 \| PIFO \| DISEASES 2334 \| AFF2 \| DISEASES 959 \| CD40LG \| DISEASES 10023 \| FRAT1 \| DISEASES 5236 \| PGM1 \| DISEASES 7422 \| VEGFA \| DISEASES 958 \| CD40 \| DISEASES 4318 \| MMP9 \| DISEASES 310 \| ANXA7 \| DISEASES 129685 \| TAF8 \| DISEASES 286204 \| CRB2 \| DISEASES 27293 \| SMPDL3B \| DISEASES 4736 \| RPL10A \| DISEASES 1896 \| EDA \| DISEASES 10880 \| ACTL7B \| DISEASES 3118 \| HLA-DQA2 \| DISEASES 23509 \| POFUT1 \| DISEASES 1460 \| CSNK2B \| DISEASES 1184 \| CLCN5 \| DISEASES 23590 \| PDSS1 \| DISEASES 3105 \| HLA-A \| DISEASES 1471 \| CST3 \| DISEASES 8718 \| TNFRSF25 \| DISEASES 8029 \| CUBN \| DISEASES 5420 \| PODXL \| DISEASES 4868 \| NPHS1 \| DISEASES 1906 \| EDN1 \| DISEASES 7222 \| TRPC3 \| DISEASES 150084 \| IGSF5 \| DISEASES 6526 \| SLC5A3 \| DISEASES 284217 \| LAMA1 \| DISEASES 51429 \| SNX9 \| DISEASES 64423 \| INF2 \| DISEASES 80310 \| PDGFD \| DISEASES 5361 \| PLXNA1 \| DISEASES 11346 \| SYNPO \| DISEASES 87 \| ACTN1 \| DISEASES 79868 \| ALG13 \| DISEASES 5532 \| PPP3CB \| DISEASES 6696 \| SPP1 \| DISEASES 83478 \| ARHGAP24 \| DISEASES 1285 \| COL4A3 \| DISEASES 1286 \| COL4A4 \| DISEASES 340990 \| OTOG \| DISEASES 81624 \| DIAPH3 \| DISEASES 55083 \| KIF26B \| DISEASES 7018 \| TF \| DISEASES 221935 \| SDK1 \| DISEASES 154810 \| AMOTL1 \| DISEASES 255743 \| NPNT \| DISEASES 85443 \| DCLK3 \| DISEASES 5005 \| ORM2 \| DISEASES 7849 \| PAX8 \| DISEASES 5076 \| PAX2 \| DISEASES 960 \| CD44 \| DISEASES 7124 \| TNF \| DISEASES 387 \| RHOA \| DISEASES 1028 \| CDKN1C \| DISEASES 3586 \| IL10 \| DISEASES 11267 \| SNF8 \| DISEASES 55998 \| NXF5 \| DISEASES 4359 \| MPZ \| DISEASES 84000 \| TMPRSS13 \| DISEASES 80790 \| CMIP \| DISEASES 567 \| B2M \| DISEASES 6139 \| RPL17 \| DISEASES 51352 \| WT1-AS \| DISEASES
Locus	(Waiting for update.)

Disease ID	333
Disease	focal segmental glomerulosclerosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:41) HP:0000100 \| Nephrosis \| 21 HP:0000093 \| Proteinuria \| 14 HP:0003774 \| End-stage renal failure \| 8 HP:0000083 \| Renal insufficiency \| 6 HP:0000112 \| Nephropathy \| 6 HP:0012588 \| Steroid-resistant nephrotic syndrome \| 5 HP:0000822 \| Hypertension \| 4 HP:0000123 \| Nephritis \| 4 HP:0000099 \| Glomerular nephritis \| 4 HP:0012579 \| Minimal change glomerulonephritis \| 3 HP:0001970 \| Interstitial nephritis \| 3 HP:0012597 \| Heavy proteinuria \| 2 HP:0001919 \| Acute renal failure \| 2 HP:0100699 \| Scarring \| 1 HP:0012578 \| Membranous glomerulonephritis \| 1 HP:0001901 \| Abnormally shaped erythrocytes \| 1 HP:0001907 \| Thromboembolic disease \| 1 HP:0008653 \| Crescentic glomerulonephritis \| 1 HP:0030162 \| Glomerulomegaly \| 1 HP:0002664 \| Neoplasia \| 1 HP:0005681 \| Juvenile idiopathic arthritis \| 1 HP:0030078 \| Lung adenocarcinoma \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0100820 \| Glomerulopathy \| 1 HP:0000096 \| Glomerulosclerosis \| 1 HP:0004737 \| Global glomerulosclerosis \| 1 HP:0012622 \| Chronic kidney disease \| 1 HP:0011748 \| Adrenocorticotropic hormone deficiency \| 1 HP:0001067 \| Neurofibromas \| 1 HP:0000092 \| Tubular atrophy \| 1 HP:0001513 \| Obesity \| 1 HP:0001271 \| Polyneuropathy \| 1 HP:0005576 \| Renal interstitial fibrosis \| 1 HP:0012574 \| Mesangial hypercellularity \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0001369 \| Arthritis \| 1 HP:0001941 \| acidemia \| 1 HP:0002613 \| Biliary cirrhosis \| 1 HP:0004729 \| Acute tubulointerstitial nephritis \| 1 HP:0006775 \| Multiple myeloma \| 1

Disease ID	333
Disease	focal segmental glomerulosclerosis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:16) C1963185 \| obesity C1963154 \| renal failure C1962972 \| proteinuria C1834580 \| ramsay hunt syndrome C1565489 \| renal insufficiency C0878486 \| arteriolosclerosis C0403398 \| steroid-dependent nephrotic syndrome C0403397 \| steroid-resistant nephrotic syndrome C0268732 \| nephritic syndrome C0220847 \| hepatitis c C0027726 \| nephrotic syndrome C0027720 \| nephrosis C0022661 \| chronic renal failure C0022660 \| acute renal failure C0020473 \| hyperlipidemia C0017665 \| membranous nephropathy
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:10) C0027726 \| nephrotic syndrome \| 20 C0033687 \| proteinuria \| 14 C0403397 \| steroid-resistant nephrotic syndrome \| 5 C0035078 \| renal failure \| 5 C0268732 \| nephritic syndrome \| 2 C0017665 \| membranous nephropathy \| 1 C0022660 \| acute renal failure \| 1 C0027720 \| nephrosis \| 1 C0028754 \| obesity \| 1 C1565489 \| renal insufficiency \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:17)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs121908415	NA	81	ACTN4	umls:C0017668	CLINVAR	NA	0.252973128	NA	ACTN4	19	38710286	A	G
rs121908415	18164029	81	ACTN4	umls:C0017668	BeFree	Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis.	0.252973128	2008	ACTN4	19	38710286	A	G
rs121908416	NA	81	ACTN4	umls:C0017668	CLINVAR	NA	0.252973128	NA	ACTN4	19	38710299	C	T
rs121908417	NA	81	ACTN4	umls:C0017668	CLINVAR	NA	0.252973128	NA	ACTN4	19	38710307	T	C
rs1799998	21777344	1585	CYP11B2	umls:C0017668	BeFree	Influence of aldosterone synthase gene C-344T polymorphism on focal segmental glomerulosclerosis.	0.000542884	2011	CYP11B2;LOC105375793	8	142918184	A	G
rs1799998	23681285	1585	CYP11B2	umls:C0017668	BeFree	We also observed that the CYP11B2 -344C/T polymorphism in the recessive model may also be an independent significant risk factor of IgAN (OR = 2.743 (95% CI = 1.219-6.172, p = 0.0122, p(corr) = 0.0366)), FSGS (OR = 2.895 (95% CI = 1.200-6.985, p = 0.0145, p(corr) = 0.0435)), and all proliferative GNs (MesPGN, IgAN, MPGN) (OR = 2.171 (95% CI = 1.211-3.894, p = 0.0084, p(corr) = 0.0252)).	0.000542884	2015	CYP11B2;LOC105375793	8	142918184	A	G
rs200042397	20947785	7827	NPHS2	umls:C0017668	BeFree	To date, very few cases with adult-onset focal segmental glomerulosclerosis (FSGS) carrying NPHS2 variants have been described, all of them being compound heterozygous for the p.R229Q variant and one pathogenic mutation.	0.144874301	2011	NPHS2;AXDND1	1	179552616	T	C
rs200042397	24715228	7827	NPHS2	umls:C0017668	BeFree	The p.R229Q variant of the NPHS2 (podocin) gene in focal segmental glomerulosclerosis and steroid-resistant nephrotic syndrome: a meta-analysis.	0.144874301	2014	NPHS2;AXDND1	1	179552616	T	C
rs200042397	23800802	7827	NPHS2	umls:C0017668	BeFree	NPHS2 homozygous p.R229Q variant: potential modifier instead of causal effect in focal segmental glomerulosclerosis.	0.144874301	2013	NPHS2;AXDND1	1	179552616	T	C
rs200042397	12464671	7827	NPHS2	umls:C0017668	BeFree	NPHS2 mutations in late-onset focal segmental glomerulosclerosis: R229Q is a common disease-associated allele.	0.144874301	2002	NPHS2;AXDND1	1	179552616	T	C
rs200042397	12707396	7827	NPHS2	umls:C0017668	BeFree	The common variant R229Q of podocin, recently associated with late-onset focal segmental glomerulosclerosis, had an overall allelic frequency of 4.2% versus 2.5% in controls.	0.144874301	2003	NPHS2;AXDND1	1	179552616	T	C
rs2239785	20668430	8542	APOL1	umls:C0017668	GAD	[A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9.]	0.00853425	2010	APOL1	22	36265284	G	A
rs28939374	24940801	4736	RPL10A	umls:C0017668	BeFree	We crossed Col1α1-eGFP-L10a mice with the Actn4(-/-) and Actn4(+/K256E) models of FSGS and analyzed podocyte transcriptional profiles at 2, 6, and 44 weeks of age.	0.000271442	2014	NA	NA	NA	NA	NA
rs28939374	24940801	81	ACTN4	umls:C0017668	BeFree	We crossed Col1α1-eGFP-L10a mice with the Actn4(-/-) and Actn4(+/K256E) models of FSGS and analyzed podocyte transcriptional profiles at 2, 6, and 44 weeks of age.	0.252973128	2014	NA	NA	NA	NA	NA
rs28939374	24940801	28915	IGKV3-7	umls:C0017668	BeFree	We crossed Col1α1-eGFP-L10a mice with the Actn4(-/-) and Actn4(+/K256E) models of FSGS and analyzed podocyte transcriptional profiles at 2, 6, and 44 weeks of age.	0.000271442	2014	NA	NA	NA	NA	NA
rs386626619	25366011	3717	JAK2	umls:C0017668	BeFree	A kidney biopsy showed focal segmental glomerulosclerosis (FSGS) with interstitial neutrophil infiltration and with a JAK2 V617F mutation.	0.000271442	2015	NA	NA	NA	NA	NA
rs77375493	25366011	3717	JAK2	umls:C0017668	BeFree	A kidney biopsy showed focal segmental glomerulosclerosis (FSGS) with interstitial neutrophil infiltration and with a JAK2 V617F mutation.	0.000271442	2015	JAK2;INSL6	9	5073770	G	A,T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:22)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0017668	benazepril	C044946	86541-75-5	glomerulosclerosis, focal segmental	MESH:D005923	therapeutic	11867951
C0017668	caffeine	D002110	1958/8/2	glomerulosclerosis, focal segmental	MESH:D005923	marker/mechanism	10803761
C0017668	cyclophosphamide	D003520	50-18-0	glomerulosclerosis, focal segmental	MESH:D005923	therapeutic	15334202
C0017668	cyclosporine	D016572	59865-13-3	glomerulosclerosis, focal segmental	MESH:D005923	therapeutic	8289993
C0017668	enalapril	D004656	75847-73-3	glomerulosclerosis, focal segmental	MESH:D005923	therapeutic	18682491
C0017668	fenoprofen	D005279	31879-05-7	glomerulosclerosis, focal segmental	MESH:D005923	marker/mechanism	10052505
C0017668	indomethacin	D007213	53-86-1	glomerulosclerosis, focal segmental	MESH:D005923	therapeutic	11849393
C0017668	norepinephrine	D009638	51-41-2	glomerulosclerosis, focal segmental	MESH:D005923	marker/mechanism	19858406
C0017668	pamidronate	C019248	40391-99-9	glomerulosclerosis, focal segmental	MESH:D005923	marker/mechanism	11979358
C0017668	paricalcitol	C084656	-	glomerulosclerosis, focal segmental	MESH:D005923	therapeutic	17513326
C0017668	propylthiouracil	D011441	51-52-5	glomerulosclerosis, focal segmental	MESH:D005923	marker/mechanism	17435868
C0017668	propylthiouracil	D011441	51-52-5	glomerulosclerosis, focal segmental	MESH:D005923	therapeutic	9695308
C0017668	reserpine	D012110	50-55-5	glomerulosclerosis, focal segmental	MESH:D005923	therapeutic	2996345
C0017668	sirolimus	D020123	53123-88-9	glomerulosclerosis, focal segmental	MESH:D005923	marker/mechanism	17362756
C0017668	sirolimus	D020123	53123-88-9	glomerulosclerosis, focal segmental	MESH:D005923	therapeutic	17550925
C0017668	spironolactone	D013148	1952/1/7	glomerulosclerosis, focal segmental	MESH:D005923	therapeutic	19429930
C0017668	streptozocin	D013311	18883-66-4	glomerulosclerosis, focal segmental	MESH:D005923	marker/mechanism	10777035
C0017668	tacrolimus	D016559	109581-93-3	glomerulosclerosis, focal segmental	MESH:D005923	marker/mechanism	9855119
C0017668	tacrolimus	D016559	109581-93-3	glomerulosclerosis, focal segmental	MESH:D005923	therapeutic	15221068
C0017668	temsirolimus	C401859	-	glomerulosclerosis, focal segmental	MESH:D005923	marker/mechanism	19212144
C0017668	tretinoin	D014212	302-79-4	glomerulosclerosis, focal segmental	MESH:D005923	therapeutic	19357873
C0017668	vitamin e	D014810	1406-18-4	glomerulosclerosis, focal segmental	MESH:D005923	therapeutic	7787149

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
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