PedAM
Pediatric Disease Annotations & Medicines
| fibrosarcoma | ||||
| Disease ID | 308 |
|---|---|
| Disease | fibrosarcoma |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:10) HP:0002664 | Neoplasia | 12 HP:0100242 | Sarcoma | 3 HP:0002721 | Immunodeficiency | 1 HP:0005387 | Combined immunodeficiency | 1 HP:0100537 | Inflammation of the fascia | 1 HP:0010614 | Fibroma | 1 HP:0100621 | Dysgerminoma | 1 HP:0010762 | Chordoma | 1 HP:0004430 | Severe combined immunodeficiency | 1 HP:0002665 | Lymphoma | 1 |
| Disease ID | 308 |
|---|---|
| Disease | fibrosarcoma |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:13) C1962974 | chylothorax C0856747 | ascending aortic aneurysm C0748355 | acute respiratory distress C0426768 | o sign C0153676 | pulmonary metastasis C0153676 | pulmonary metastases C0153676 | lung metastases C0022408 | arthropathy C0020473 | hyperlipidemia C0020305 | hydrops fetalis C0014145 | yolk sac tumor C0002874 | aplastic anaemia C0002793 | anaplasia |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:2) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:2) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs113488022 | 14500344 | 673 | BRAF | umls:C0016057 | BeFree | Similar targeting of BRAF(V599E) or wild-type BRAF in human fibrosarcoma cells that lack the BRAF(V599E) mutation does not recapitulate these effects. | 0.000271442 | 2003 | BRAF | 7 | 140753336 | A | T,G,C |
| rs121913499 | 22885298 | 3417 | IDH1 | umls:C0016057 | BeFree | Here, using a genetically engineered inducible system, we report that selective suppression of endogenous mutant IDH1 expression in HT1080, a fibrosarcoma cell line with a native IDH1(R132C) heterozygous mutation, significantly inhibits cell proliferation and decreases clonogenic potential. | 0.000271442 | 2012 | IDH1 | 2 | 208248389 | G | T,A |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:3) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0016057 | arsenic trioxide | C006632 | 1327-53-3 | fibrosarcoma | MESH:D005354 | therapeutic | 10626785 | ||
| C0016057 | cisplatin | D002945 | 15663-27-1 | fibrosarcoma | MESH:D005354 | therapeutic | 24012798 | ||
| C0016057 | indomethacin | D007213 | 53-86-1 | fibrosarcoma | MESH:D005354 | therapeutic | 10962813 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |