PedAM
Pediatric Disease Annotations & Medicines
| febrile seizures | ||||
| Disease ID | 621 |
|---|---|
| Disease | febrile seizures |
| Definition | Seizures that occur during a febrile episode. It is a common condition, affecting 2-5% of children aged 3 months to five years. An autosomal dominant pattern of inheritance has been identified in some families. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy (i.e., a nonfebrile seizure disorder) following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. (From Menkes, Textbook of Child Neurology, 5th ed, p784) |
| Synonym | [d]convulsions, febrile [d]convulsions, febrile (context-dependent category) [d]convulsions, febrile (situation) [d]pyrexial convulsion convulsion febrile convulsion fever convulsion, febrile convulsion, fever convulsion, pyrexial convulsions febrile seizures convulsions, febrile convulsions, fever convulsions, pyrexial febrile convulsion febrile convulsion (finding) febrile convulsion seizure febrile convulsion seizures febrile convulsions febrile convulsions (finding) febrile convulsions (simple), unspecified febrile convulsions nos febrile fit febrile fits febrile seizure febrile seizure (from fever) febrile seizures nos fever convulsion fever convulsions fever induced seizures fever seizure fever seizures fevers seizures fit, febrile fits, febrile pyrexial convulsion pyrexial convulsions pyrexial seizure pyrexial seizures seizure febrile seizure fever seizure, febrile seizure, febrile convulsion seizure, fever seizure, pyrexial seizures fever seizures, febrile seizures, febrile [disease/finding] seizures, febrile convulsion seizures, febrile, in early childhood seizures, fever seizures, generalized, associated with fever seizures, pyrexial |
| UMLS | C0009952 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:27) C0014544 | epilepsy | 95 C0014544 | epilepsies | 5 C0017160 | gastroenteritis | 4 C0014556 | temporal lobe epilepsy | 4 C0343363 | rotavirus gastroenteritis | 3 C0679466 | cognitive deficits | 2 C0025007 | measles | 2 C0014547 | partial epilepsy | 2 C0085437 | bacterial meningitis | 1 C0004096 | asthma | 1 C0042769 | viral infection | 1 C0042769 | viral infections | 1 C0014553 | absence epilepsy | 1 C0031069 | familial mediterranean fever | 1 C0014038 | encephalitis | 1 C0020598 | hypoglycemia | 1 C0015230 | exanthem | 1 C0751122 | dravet syndrome | 1 C0015231 | exanthem subitum | 1 C0162316 | iron deficiency anemia | 1 C0002871 | anemia | 1 C0042769 | virus infection | 1 C0014553 | childhood absence epilepsy | 1 C0159020 | neonatal seizures | 1 C0035021 | recurrent fever | 1 C0243010 | viral encephalitis | 1 C0035309 | retinopathy | 1 |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:11) |
| Inferring Gene | Entrez_id | Symbol | Resource(Total Genes:23) 1137 | CHRNA4 | infer 1268 | CNR1 | infer 2566 | GABRG2 | infer 2697 | GJA1 | infer 3553 | IL1B | infer 6326 | SCN2A | infer 6508 | SLC4A3 | infer 6548 | SLC9A1 | infer 6550 | SLC9A3 | infer 627 | BDNF | infer 1141 | CHRNB2 | infer 1455 | CSNK1G2 | infer 610 | HCN2 | infer 3586 | IL10 | infer 3552 | IL1A | infer 3554 | IL1R1 | infer 3557 | IL1RN | infer 3565 | IL4 | infer 3569 | IL6 | infer 3613 | IMPA2 | infer 4852 | NPY | infer 57526 | PCDH19 | infer 7124 | TNF | infer |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 621 |
|---|---|
| Disease | febrile seizures |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:23) HP:0001250 | Seizures | 9 HP:0001945 | Fever | 5 HP:0100543 | Cognitive deficits | 2 HP:0001298 | Encephalopathy | 2 HP:0002197 | Generalized seizures | 1 HP:0000010 | Frequent urinary tract infections | 1 HP:0001268 | Mental deterioration | 1 HP:0000573 | Retinal hemorrhage | 1 HP:0002099 | Asthma | 1 HP:0002902 | Hyponatremia | 1 HP:0000488 | Noninflammatory retina disease | 1 HP:0001943 | Hypoglycemia | 1 HP:0001903 | Anemia | 1 HP:0006846 | Acute encephalopathy | 1 HP:0001891 | Iron-deficiency anemia | 1 HP:0002883 | Rapid breathing | 1 HP:0002383 | Encephalitis | 1 HP:0000988 | Exanthem | 1 HP:0007018 | Attention deficits | 1 HP:0001950 | Respiratory alkalosis | 1 HP:0001948 | Alkalosis | 1 HP:0003401 | Paresthesia | 1 HP:0011947 | Respiratory infection | 1 |
| Disease ID | 621 |
|---|---|
| Disease | febrile seizures |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:6) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:5) C0014544 | epilepsy | 93 C0014556 | temporal lobe epilepsy | 4 C0014544 | epilepsies | 3 C0015967 | fever | 3 C0042769 | viral infections | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:41) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs11105468 | 25344690 | 6323 | SCN1A | umls:C0009952 | BeFree | Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)). | 0.277300664 | 2014 | LOC105369890 | 12 | 89935056 | T | A |
| rs11105468 | 25344690 | 6326 | SCN2A | umls:C0009952 | BeFree | Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)). | 0.246362715 | 2014 | LOC105369890 | 12 | 89935056 | T | A |
| rs11105468 | 25344690 | 63982 | ANO3 | umls:C0009952 | BeFree | Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)). | 0.120271442 | 2014 | LOC105369890 | 12 | 89935056 | T | A |
| rs114444506 | 25344690 | 6326 | SCN2A | umls:C0009952 | BeFree | Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)). | 0.246362715 | 2014 | ANO3 | 11 | 26325284 | T | C |
| rs114444506 | 25344690 | 6323 | SCN1A | umls:C0009952 | BeFree | Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)). | 0.277300664 | 2014 | ANO3 | 11 | 26325284 | T | C |
| rs114444506 | 25344690 | 63982 | ANO3 | umls:C0009952 | BeFree | Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)). | 0.120271442 | 2014 | ANO3 | 11 | 26325284 | T | C |
| rs121909673 | 21930603 | 2566 | GABRG2 | umls:C0009952 | BeFree | The R46W mutation is located in a region homologous to a GABA(A) receptor γ2 subunit missense mutation, R82Q, that is associated with CAE and febrile seizures in humans. | 0.142613009 | 2011 | GABRG2 | 5 | 162093965 | G | A |
| rs121917748 | 17641256 | 6326 | SCN2A | umls:C0009952 | BeFree | We attempted to identify the prevalence of the R188W mutation of the SCN2A gene and the K289M mutation and single-nucleotide polymorphism rs211014 of the GABRG2 gene in children of southern China who have febrile seizures. | 0.246362715 | 2007 | SCN2A | 2 | 165308751 | C | T |
| rs121917748 | 17641256 | 2566 | GABRG2 | umls:C0009952 | BeFree | We attempted to identify the prevalence of the R188W mutation of the SCN2A gene and the K289M mutation and single-nucleotide polymorphism rs211014 of the GABRG2 gene in children of southern China who have febrile seizures. | 0.142613009 | 2007 | SCN2A | 2 | 165308751 | C | T |
| rs121917748 | 11371648 | 6326 | SCN2A | umls:C0009952 | BeFree | Here, we report a mutation resulting in an amino acid exchange (R188W) [corrected] in the gene encoding the alpha-subunit of neuronal voltage-gated Na(+) channel type II (Na(v)1.2) in a patient with FS associated with afebrile seizures. | 0.246362715 | 2001 | SCN2A | 2 | 165308751 | C | T |
| rs13004083 | 25344690 | 101929680 | LOC101929680 | umls:C0009952 | GWASCAT | Common variants associated with general and MMR vaccine-related febrile seizures. | 0.12 | 2014 | SCN1A;LOC101929680 | 2 | 166088857 | A | G |
| rs13004083 | 25344690 | 6323 | SCN1A | umls:C0009952 | GWASCAT | Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)). | 0.277300664 | 2014 | SCN1A;LOC101929680 | 2 | 166088857 | A | G |
| rs1318653 | 25344690 | 4179 | CD46 | umls:C0009952 | BeFree | Two loci were distinctly associated with MMR-related febrile seizures, harboring the interferon-stimulated gene IFI44L (rs273259: P = 5.9 × 10(-12) versus controls, P = 1.2 × 10(-9) versus MMR-unrelated febrile seizures) and the measles virus receptor CD46 (rs1318653: P = 9.6 × 10(-11) versus controls, P = 1.6 × 10(-9) versus MMR-unrelated febrile seizures). | 0.120271442 | 2014 | C1orf132 | 1 | 207841577 | T | C |
| rs1318653 | 25344690 | 10964 | IFI44L | umls:C0009952 | BeFree | Two loci were distinctly associated with MMR-related febrile seizures, harboring the interferon-stimulated gene IFI44L (rs273259: P = 5.9 × 10(-12) versus controls, P = 1.2 × 10(-9) versus MMR-unrelated febrile seizures) and the measles virus receptor CD46 (rs1318653: P = 9.6 × 10(-11) versus controls, P = 1.6 × 10(-9) versus MMR-unrelated febrile seizures). | 0.120271442 | 2014 | C1orf132 | 1 | 207841577 | T | C |
| rs16850331 | 20041941 | 6326 | SCN2A | umls:C0009952 | BeFree | Two SCN2A SNPs (rs3943809 and rs16850331) were associated by case-control with a subgroup with IGE and history of febrile seizures and also by transmission disequilibrium test (TDT) in parent-proband trios. | 0.246362715 | 2010 | SCN2A | 2 | 165292743 | C | T |
| rs1799724 | 19055487 | 3569 | IL6 | umls:C0009952 | BeFree | The promoter SNPs of four inflammatory cytokine genes (IL6 -572C/G, IL8 -251A/T, IL10 -592A/C and TNFA -1037C/T) were examined in 249 patients with FS (186 simple and 63 complex FS) and 225 controls. | 0.008815624 | 2009 | LTA;TNF | 6 | 31574705 | C | T |
| rs1799724 | 19055487 | 7124 | TNF | umls:C0009952 | BeFree | The promoter SNPs of four inflammatory cytokine genes (IL6 -572C/G, IL8 -251A/T, IL10 -592A/C and TNFA -1037C/T) were examined in 249 patients with FS (186 simple and 63 complex FS) and 225 controls. | 0.00554839 | 2009 | LTA;TNF | 6 | 31574705 | C | T |
| rs211014 | 17641256 | 2566 | GABRG2 | umls:C0009952 | BeFree | We attempted to identify the prevalence of the R188W mutation of the SCN2A gene and the K289M mutation and single-nucleotide polymorphism rs211014 of the GABRG2 gene in children of southern China who have febrile seizures. | 0.142613009 | 2007 | GABRG2 | 5 | 162149412 | C | A |
| rs211014 | 17641256 | 6326 | SCN2A | umls:C0009952 | BeFree | We attempted to identify the prevalence of the R188W mutation of the SCN2A gene and the K289M mutation and single-nucleotide polymorphism rs211014 of the GABRG2 gene in children of southern China who have febrile seizures. | 0.246362715 | 2007 | GABRG2 | 5 | 162149412 | C | A |
| rs211037 | 23140995 | 2566 | GABRG2 | umls:C0009952 | BeFree | This study showed significant association of GABRG2 rs211037 with susceptibility to FS, caused by two studies with small sample sizes, however the possibility of false positive results due to the effect of significant studies for FS cannot be excluded. | 0.142613009 | 2013 | GABRG2 | 5 | 162101274 | C | T |
| rs211037 | 24061200 | 2566 | GABRG2 | umls:C0009952 | BeFree | GABRG2, rs211037 is associated with epilepsy susceptibility, but not with antiepileptic drug resistance and febrile seizures. | 0.142613009 | 2014 | GABRG2 | 5 | 162101274 | C | T |
| rs2724384 | 25344690 | 4179 | CD46 | umls:C0009952 | GWASCAT | Two loci were distinctly associated with MMR-related febrile seizures, harboring the interferon-stimulated gene IFI44L (rs273259: P = 5.9 × 10(-12) versus controls, P = 1.2 × 10(-9) versus MMR-unrelated febrile seizures) and the measles virus receptor CD46 (rs1318653: P = 9.6 × 10(-11) versus controls, P = 1.6 × 10(-9) versus MMR-unrelated febrile seizures). | 0.120271442 | 2014 | CD46 | 1 | 207756858 | G | A |
| rs273259 | 25344690 | 10964 | IFI44L | umls:C0009952 | BeFree | Two loci were distinctly associated with MMR-related febrile seizures, harboring the interferon-stimulated gene IFI44L (rs273259: P = 5.9 × 10(-12) versus controls, P = 1.2 × 10(-9) versus MMR-unrelated febrile seizures) and the measles virus receptor CD46 (rs1318653: P = 9.6 × 10(-11) versus controls, P = 1.6 × 10(-9) versus MMR-unrelated febrile seizures). | 0.120271442 | 2014 | IFI44L | 1 | 78628133 | A | G |
| rs273259 | 25344690 | 4179 | CD46 | umls:C0009952 | BeFree | Two loci were distinctly associated with MMR-related febrile seizures, harboring the interferon-stimulated gene IFI44L (rs273259: P = 5.9 × 10(-12) versus controls, P = 1.2 × 10(-9) versus MMR-unrelated febrile seizures) and the measles virus receptor CD46 (rs1318653: P = 9.6 × 10(-11) versus controls, P = 1.6 × 10(-9) versus MMR-unrelated febrile seizures). | 0.120271442 | 2014 | IFI44L | 1 | 78628133 | A | G |
| rs273259 | 25344690 | 10964 | IFI44L | umls:C0009952 | GWASCAT | Two loci were distinctly associated with MMR-related febrile seizures, harboring the interferon-stimulated gene IFI44L (rs273259: P = 5.9 × 10(-12) versus controls, P = 1.2 × 10(-9) versus MMR-unrelated febrile seizures) and the measles virus receptor CD46 (rs1318653: P = 9.6 × 10(-11) versus controls, P = 1.6 × 10(-9) versus MMR-unrelated febrile seizures). | 0.120271442 | 2014 | IFI44L | 1 | 78628133 | A | G |
| rs2910164 | 25319229 | 3146 | HMGB1 | umls:C0009952 | BeFree | Association of genetic polymorphism of pre-microRNA-146a rs2910164 and serum high-mobility group box 1 with febrile seizures in Egyptian children. | 0.000271442 | 2014 | LOC285628;MIR146A | 5 | 160485411 | C | G |
| rs2910164 | 25319229 | 406938 | MIR146A | umls:C0009952 | BeFree | Association of genetic polymorphism of pre-microRNA-146a rs2910164 and serum high-mobility group box 1 with febrile seizures in Egyptian children. | 0.000271442 | 2014 | LOC285628;MIR146A | 5 | 160485411 | C | G |
| rs3130618 | 25344690 | 7918 | GPANK1 | umls:C0009952 | GWASCAT | Common variants associated with general and MMR vaccine-related febrile seizures. | 0.12 | 2014 | CSNK2B;GPANK1 | 6 | 31664357 | C | A |
| rs3130618 | 25344690 | 1460 | CSNK2B | umls:C0009952 | GWASCAT | Common variants associated with general and MMR vaccine-related febrile seizures. | 0.12 | 2014 | CSNK2B;GPANK1 | 6 | 31664357 | C | A |
| rs3769955 | 25344690 | 6326 | SCN2A | umls:C0009952 | GWASCAT | Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)). | 0.246362715 | 2014 | SCN2A | 2 | 165378122 | C | T |
| rs3769955 | 25344690 | 63982 | ANO3 | umls:C0009952 | BeFree | Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)). | 0.120271442 | 2014 | SCN2A | 2 | 165378122 | C | T |
| rs3769955 | 25344690 | 6323 | SCN1A | umls:C0009952 | BeFree | Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)). | 0.277300664 | 2014 | SCN2A | 2 | 165378122 | C | T |
| rs3769955 | 25344690 | 6326 | SCN2A | umls:C0009952 | BeFree | Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)). | 0.246362715 | 2014 | SCN2A | 2 | 165378122 | C | T |
| rs3812718 | 22578703 | 6323 | SCN1A | umls:C0009952 | BeFree | Failure to find association between febrile seizures and SCN1A rs3812718 polymorphism in south Indian patients with mesial temporal lobe epilepsy and hippocampal sclerosis. | 0.277300664 | 2012 | SCN1A | 2 | 166053034 | C | T |
| rs3812718 | 24076350 | 6323 | SCN1A | umls:C0009952 | BeFree | SCN1A rs3812718 polymorphism and susceptibility to epilepsy with febrile seizures: a meta-analysis. | 0.277300664 | 2013 | SCN1A | 2 | 166053034 | C | T |
| rs386602118 | 15279867 | 627 | BDNF | umls:C0009952 | BeFree | Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in febrile seizures. | 0.002995792 | 2004 | NA | NA | NA | NA | NA |
| rs3943809 | 20041941 | 6326 | SCN2A | umls:C0009952 | BeFree | Two SCN2A SNPs (rs3943809 and rs16850331) were associated by case-control with a subgroup with IGE and history of febrile seizures and also by transmission disequilibrium test (TDT) in parent-proband trios. | 0.246362715 | 2010 | SCN2A | 2 | 165344371 | A | G |
| rs6432860 | 25344690 | 6323 | SCN1A | umls:C0009952 | BeFree | Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)). | 0.277300664 | 2014 | SCN1A | 2 | 166041354 | A | G,T |
| rs6432860 | 25344690 | 6323 | SCN1A | umls:C0009952 | GWASCAT | Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)). | 0.277300664 | 2014 | SCN1A | 2 | 166041354 | A | G,T |
| rs6432860 | 25344690 | 63982 | ANO3 | umls:C0009952 | BeFree | Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)). | 0.120271442 | 2014 | SCN1A | 2 | 166041354 | A | G,T |
| rs6432860 | 25344690 | 6326 | SCN2A | umls:C0009952 | BeFree | Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)). | 0.246362715 | 2014 | SCN1A | 2 | 166041354 | A | G,T |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:3) | |||||||||
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| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0009952 | carbamazepine | D002220 | 298-46-4 | seizures, febrile | MESH:D003294 | therapeutic | 6504639 | ||
| C0009952 | phenytoin | D010672 | 57-41-0 | seizures, febrile | MESH:D003294 | therapeutic | 20728059 | ||
| C0009952 | valproic acid | D014635 | 99-66-1 | seizures, febrile | MESH:D003294 | therapeutic | 6796420 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |