PedAM

Pediatric Disease Annotations & Medicines


	extrapulmonary tuberculosis

Disease ID	1996
Disease	extrapulmonary tuberculosis
Synonym	extra pulmonary tuberculosis extra-pulmonary tuberculosis tb, extrapulmonary tuberculosis extrapulmonary tuberculosis, extrapulmonary tuberculosis, extrapulmonary (disorder)
DOID	DOID:0050598
UMLS	C0679362
SNOMED-CT	SNOMEDCT_US_2016_09_01:423997002
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:15) C0041296 \| tuberculosis \| 4 C0024299 \| lymphomas \| 1 C0039103 \| synovitis \| 1 C0041333 \| genitourinary tuberculosis \| 1 C0079744 \| diffuse large b-cell lymphoma \| 1 C0275911 \| intestinal tuberculosis \| 1 C0041327 \| pulmonary tuberculosis \| 1 C0024299 \| lymphoma \| 1 C0037116 \| silicosis \| 1 C0041326 \| tuberculous pleurisy \| 1 C0079731 \| b-cell lymphoma \| 1 C0032231 \| pleurisy \| 1 C0041332 \| urinary tuberculosis \| 1 C0024115 \| pulmonary disease \| 1 C0029443 \| osteomyelitis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:159) 1472 \| CST4 \| DISEASES 7076 \| TIMP1 \| DISEASES 6367 \| CCL22 \| DISEASES 1178 \| CLC \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 1048 \| CEACAM5 \| DISEASES 10061 \| ABCF2 \| DISEASES 6348 \| CCL3 \| DISEASES 6347 \| CCL2 \| DISEASES 6346 \| CCL1 \| DISEASES 3558 \| IL2 \| DISEASES 969 \| CD69 \| DISEASES 3458 \| IFNG \| DISEASES 2026 \| ENO2 \| DISEASES 6908 \| TBP \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 9168 \| TMSB10 \| DISEASES 6556 \| SLC11A1 \| DISEASES 6402 \| SELL \| DISEASES 9499 \| MYOT \| DISEASES 79441 \| HAUS3 \| DISEASES 3623 \| INHA \| DISEASES 54210 \| TREM1 \| DISEASES 2342 \| FNTB \| DISEASES 1236 \| CCR7 \| DISEASES 10131 \| TRAP1 \| DISEASES 7355 \| SLC35A2 \| DISEASES 9119 \| KRT75 \| DISEASES 1401 \| CRP \| DISEASES 10955 \| SERINC3 \| DISEASES 26122 \| EPC2 \| DISEASES 3569 \| IL6 \| DISEASES 7097 \| TLR2 \| DISEASES 10068 \| IL18BP \| DISEASES 4069 \| LYZ \| DISEASES 3553 \| IL1B \| DISEASES 5443 \| POMC \| DISEASES 3383 \| ICAM1 \| DISEASES 939 \| CD27 \| DISEASES 963 \| CD53 \| DISEASES 10899 \| JTB \| DISEASES 5972 \| REN \| DISEASES 6167 \| RPL37 \| DISEASES 3606 \| IL18 \| DISEASES 55079 \| FEZF2 \| DISEASES 50940 \| PDE11A \| DISEASES 50848 \| F11R \| DISEASES 1636 \| ACE \| DISEASES 1234 \| CCR5 \| DISEASES 6352 \| CCL5 \| DISEASES 2215 \| FCGR3B \| DISEASES 72 \| ACTG2 \| DISEASES 213 \| ALB \| DISEASES 1230 \| CCR1 \| DISEASES 3600 \| IL15 \| DISEASES 3562 \| IL3 \| DISEASES 64127 \| NOD2 \| DISEASES 94235 \| GNG8 \| DISEASES 55957 \| LIN37 \| DISEASES 94274 \| PPP1R14A \| DISEASES 3603 \| IL16 \| DISEASES 5481 \| PPID \| DISEASES 23491 \| CES3 \| DISEASES 3627 \| CXCL10 \| DISEASES 56246 \| MRAP \| DISEASES 6373 \| CXCL11 \| DISEASES 23592 \| LEMD3 \| DISEASES 4046 \| LSP1 \| DISEASES 2147 \| F2 \| DISEASES 344561 \| GPR148 \| DISEASES 1657 \| DMXL1 \| DISEASES 9024 \| BRSK2 \| DISEASES 1521 \| CTSW \| DISEASES 1474 \| CST6 \| DISEASES 89872 \| AQP10 \| DISEASES 4684 \| NCAM1 \| DISEASES 7706 \| TRIM25 \| DISEASES 2 \| A2M \| DISEASES 286826 \| LIN9 \| DISEASES 9146 \| HGS \| DISEASES 3916 \| LAMP1 \| DISEASES 3751 \| KCND2 \| DISEASES 9094 \| UNC119 \| DISEASES 3983 \| ABLIM1 \| DISEASES 140823 \| ROMO1 \| DISEASES 23583 \| SMUG1 \| DISEASES 3329 \| HSPD1 \| DISEASES 4882 \| NPR2 \| DISEASES 84335 \| AKT1S1 \| DISEASES 3605 \| IL17A \| DISEASES 23481 \| PES1 \| DISEASES 9260 \| PDLIM7 \| DISEASES 3240 \| HP \| DISEASES 91137 \| SLC25A46 \| DISEASES 9600 \| PITPNM1 \| DISEASES 5725 \| PTBP1 \| DISEASES 11194 \| ABCB8 \| DISEASES 93034 \| NT5C1B \| DISEASES 6772 \| STAT1 \| DISEASES 4283 \| CXCL9 \| DISEASES 65217 \| PCDH15 \| DISEASES 5455 \| POU3F3 \| DISEASES 3880 \| KRT19 \| DISEASES 93273 \| LEMD1 \| DISEASES 5788 \| PTPRC \| DISEASES 2214 \| FCGR3A \| DISEASES 2316 \| FLNA \| DISEASES 959 \| CD40LG \| DISEASES 9211 \| LGI1 \| DISEASES 4318 \| MMP9 \| DISEASES 80712 \| ESX1 \| DISEASES 100 \| ADA \| DISEASES 200081 \| TXLNA \| DISEASES 80312 \| TET1 \| DISEASES 2833 \| CXCR3 \| DISEASES 9371 \| KIF3B \| DISEASES 50943 \| FOXP3 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 160897 \| GPR180 \| DISEASES 1910 \| EDNRB \| DISEASES 94027 \| CGB7 \| DISEASES 133482 \| SLCO6A1 \| DISEASES 10455 \| ECI2 \| DISEASES 551 \| AVP \| DISEASES 5214 \| PFKP \| DISEASES 7932 \| OR2H2 \| DISEASES 3660 \| IRF2 \| DISEASES 51520 \| LARS \| DISEASES 51059 \| FAM135B \| DISEASES 6387 \| CXCL12 \| DISEASES 4689 \| NCF4 \| DISEASES 80380 \| PDCD1LG2 \| DISEASES 729920 \| ISPD \| DISEASES 7852 \| CXCR4 \| DISEASES 57703 \| CWC22 \| DISEASES 26013 \| L3MBTL1 \| DISEASES 7124 \| TNF \| DISEASES 3594 \| IL12RB1 \| DISEASES 94115 \| CGB8 \| DISEASES 283337 \| ZNF740 \| DISEASES 389549 \| FEZF1 \| DISEASES 3586 \| IL10 \| DISEASES 58155 \| PTBP2 \| DISEASES 51071 \| DERA \| DISEASES 5447 \| POR \| DISEASES 5158 \| PDE6B \| DISEASES 8530 \| CST7 \| DISEASES 158835 \| AWAT2 \| DISEASES 10189 \| ALYREF \| DISEASES 2533 \| FYB \| DISEASES 930 \| CD19 \| DISEASES 5027 \| P2RX7 \| DISEASES 91750 \| LIN52 \| DISEASES 567 \| B2M \| DISEASES 63895 \| PIEZO2 \| DISEASES 246734 \| NPCDR1 \| DISEASES 79104 \| MEG8 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1996
Disease	extrapulmonary tuberculosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:6) HP:0100769 \| Synovitis \| 1 HP:0002527 \| Falls \| 1 HP:0012191 \| B-cell lymphoma \| 1 HP:0002665 \| Lymphoma \| 1 HP:0002754 \| Bone infection \| 1 HP:0002102 \| Pleuritis \| 1

Disease ID	1996
Disease	extrapulmonary tuberculosis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0009450 \| infection \| 2 C0748159 \| pulmonary involvement \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:5)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1799864	19942750	6347	CCL2	umls:C0679362	BeFree	CCR2 V64I (G/A), monocyte chemoattractant protein-1 (MCP-1) -2518 A/G, stromal cell derived factor-1alpha; (SDF-1alpha) 3'UTR G/A and DC-SIGN gene polymorphisms were studied by polymerase chain reaction based methods in HIV-1 infected patients without TB (n=151), with pulmonary TB (PTB) (n=81) and extrapulmonary TB (n=31), 155 PTB patients without HIV and 206 healthy controls.	0.000542884	2009	CCR2	3	46357717	G	A
rs1800972	23953711	5725	PTBP1	umls:C0679362	BeFree	SNP rs1800972 was associated with extrapulmonary tuberculosis (EPTB) in a codominant model (genotype CG, P = 0.037, OR 4.82; 95% CI: 0.92-47.42; statistical power, 82%), but not PTB (P = 0.101) in a Mexican population.	0.000542884	2013	DEFB1	8	6877901	C	G
rs2243268	24518693	3565	IL4	umls:C0679362	BeFree	In conclusion, rs2243268-A and rs2243274-G of the IL-4 gene were found to confer resistance to EPTB and severe TB in Chinese Han children.	0.000271442	2014	IL4	5	132678271	A	C
rs2243274	24518693	3565	IL4	umls:C0679362	BeFree	In conclusion, rs2243268-A and rs2243274-G of the IL-4 gene were found to confer resistance to EPTB and severe TB in Chinese Han children.	0.000271442	2014	IL4;LOC105379176	5	132679140	G	A
rs5743708	21320563	7097	TLR2	umls:C0679362	BeFree	Our data suggest that the Arg753Gln polymorphism of the TLR-2 gene influences the speed of progression from infection to TB disease in children.	0.000542884	2011	TLR2	4	153705165	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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