PedAM

Pediatric Disease Annotations & Medicines


	evans syndrome

Disease ID	220
Disease	evans syndrome
Definition	A rare, chronic and relapsing autoimmune disorder of unknown etiology, characterized by the presence of immune thrombocytopenia and autoimmune hemolytic anemia.
Synonym	autoimmune hemolytic anemia and autoimmune thrombocytopenia evan syndrome evan's syndrome evans syndrome (disorder) evans' syndrome evans's syndrome
Orphanet	ORPHANET:1959
DOID	DOID:8931
ICD10	ICD10CM:D69.41
UMLS	C0272126
SNOMED-CT	SNOMEDCT_US_2016_09_01:75331009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:27) C0043117 \| idiopathic thrombocytopenic purpura \| 2 C0034150 \| purpura \| 2 C0008312 \| primary biliary cirrhosis \| 1 C0042769 \| viral infection \| 1 C0008312 \| biliary cirrhosis \| 1 C0027051 \| myocardial infarction \| 1 C0085278 \| antiphospholipid syndrome \| 1 C0003873 \| rheumatoid arthritis \| 1 C0002880 \| autoimmune hemolytic anemia \| 1 C0023890 \| cirrhosis \| 1 C0409974 \| lupus erythematosus \| 1 C0024299 \| lymphoma \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0206754 \| neuroendocrine tumor \| 1 C0018213 \| graves' disease \| 1 C0003864 \| arthritis \| 1 C0019243 \| hereditary angioedema \| 1 C0155626 \| acute myocardial infarction \| 1 C0677607 \| hashimoto's thyroiditis \| 1 C0002871 \| anemia \| 1 C1328840 \| autoimmune lymphoproliferative syndrome \| 1 C0040147 \| thyroiditis \| 1 C0002878 \| hemolytic anemia \| 1 C0042769 \| virus infection \| 1 C0021053 \| immune disease \| 1 C0042769 \| viral infections \| 1 C0027051 \| myocardial infarct \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:54) 104940698 \| DALIR \| DISEASES 30009 \| TBX21 \| DISEASES 350 \| APOH \| DISEASES 973 \| CD79A \| DISEASES 969 \| CD69 \| DISEASES 718 \| C3 \| DISEASES 1236 \| CCR7 \| DISEASES 84262 \| PSMG3 \| DISEASES 182 \| JAG1 \| DISEASES 64240 \| ABCG5 \| DISEASES 7450 \| VWF \| DISEASES 3690 \| ITGB3 \| DISEASES 3674 \| ITGA2B \| DISEASES 943 \| TNFRSF8 \| DISEASES 7535 \| ZAP70 \| DISEASES 64241 \| ABCG8 \| DISEASES 6567 \| SLC16A2 \| DISEASES 3439 \| IFNA1 \| DISEASES 710 \| SERPING1 \| DISEASES 115650 \| TNFRSF13C \| DISEASES 326 \| AIRE \| DISEASES 6006 \| RHCE \| DISEASES 915 \| CD3D \| DISEASES 154 \| ADRB2 \| DISEASES 3575 \| IL7R \| DISEASES 27087 \| B3GAT1 \| DISEASES 1604 \| CD55 \| DISEASES 6007 \| RHD \| DISEASES 2152 \| F3 \| DISEASES 966 \| CD59 \| DISEASES 2624 \| GATA2 \| DISEASES 3767 \| KCNJ11 \| DISEASES 3792 \| KEL \| DISEASES 9260 \| PDLIM7 \| DISEASES 3240 \| HP \| DISEASES 987 \| LRBA \| DISEASES 50485 \| SMARCAL1 \| DISEASES 5079 \| PAX5 \| DISEASES 84061 \| MAGT1 \| DISEASES 6905 \| TBCE \| DISEASES 1380 \| CR2 \| DISEASES 959 \| CD40LG \| DISEASES 11093 \| ADAMTS13 \| DISEASES 1043 \| CD52 \| DISEASES 199 \| AIF1 \| DISEASES 7174 \| TPP2 \| DISEASES 50943 \| FOXP3 \| DISEASES 3105 \| HLA-A \| DISEASES 5293 \| PIK3CD \| DISEASES 3030 \| HADHA \| DISEASES 83650 \| SLC35G5 \| DISEASES 5450 \| POU2AF1 \| DISEASES 3106 \| HLA-B \| DISEASES 917 \| CD3G \| DISEASES
Locus	(Waiting for update.)

Disease ID	220
Disease	evans syndrome
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:13) HP:0000980 \| Pallor HP:0001254 \| Lethargy HP:0001279 \| Syncope HP:0012378 \| Fatigue HP:0001324 \| Muscle weakness HP:0001973 \| Autoimmune thrombocytopenia HP:0000952 \| Jaundice HP:0000421 \| Epistaxis HP:0001890 \| Autoimmune hemolytic anemia HP:0000967 \| Petechiae HP:0001904 \| Autoimmune neutropenia HP:0000978 \| Bruising susceptibility HP:0002094 \| Dyspnea
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:17) HP:0000979 \| Purpura \| 2 HP:0002960 \| Autoimmune condition \| 1 HP:0001658 \| Myocardial infarction \| 1 HP:0001981 \| Schistocytosis \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0001903 \| Anemia \| 1 HP:0002665 \| Lymphoma \| 1 HP:0100646 \| Thyroiditis \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0001890 \| Autoimmune hemolytic anemia \| 1 HP:0000872 \| Hashimoto's thyroiditis \| 1 HP:0001878 \| Haemolytic anaemia \| 1 HP:0012190 \| T cell lymphoma \| 1 HP:0001369 \| Arthritis \| 1 HP:0001394 \| Hepatic cirrhosis \| 1 HP:0002613 \| Biliary cirrhosis \| 1

Disease ID	220
Disease	evans syndrome
Manually Symptom	UMLS \| Name(Total Manually Symptoms:9) C0876991 \| haemophagocytosis C0349532 \| gastric lymphoma C0242770 \| bronchiolitis obliterans organizing pneumonia C0151945 \| cerebral venous thrombosis C0040034 \| thrombocytopenia C0018923 \| angiosarcoma C0018213 \| basedow disease C0009447 \| common variable immunodeficiency C0002880 \| autoimmune hemolytic anemia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0002880 \| autoimmune hemolytic anemia \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0001890	Autoimmune hemolytic anemia	MP:0001577	anemia;HP:0005305	Cerebral venous thrombosis

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0001890	Autoimmune hemolytic anemia	MP:0002420	abnormal adaptive immunity;HP:0045038	Gastric lymphoma

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0272126	ramipril	D017257	87333-19-5	evans syndrome	MESH:C536380	marker/mechanism	9471950

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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