PedAM
Pediatric Disease Annotations & Medicines
| esophagus adenocarcinoma | ||||
| Disease ID | 1246 |
|---|---|
| Disease | esophagus adenocarcinoma |
| Definition | A malignant tumor with glandular differentiation arising predominantly from Barrett mucosa in the lower third of the esophagus. Rare examples of esophageal adenocarcinoma deriving from ectopic gastric mucosa in the upper esophagus have also been reported. Grossly, esophageal adenocarcinomas are similar to esophageal squamous cell carcinomas. Microscopically, adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. The prognosis is poor. |
| Synonym | adenocarcinoma - esophagus adenocarcinoma esophageal adenocarcinoma esophagus adenocarcinoma oesophagus adenocarcinoma of esophagus adenocarcinoma of esophagus (disorder) adenocarcinoma of oesophagus adenocarcinoma of the esophagus cancer esophagus adenocarcinoma esophageal adenocarcinoma esophageal cancer, adenocarcinoma esophagus cancer, adenocarcinoma oesophageal adenocarcinoma oesophageal adenocarcinoma nos |
| Orphanet | |
| DOID | |
| UMLS | C0279628 |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:1) |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:14) PIK3CA | 5290 | CTD_human TP53 | 7157 | CTD_human SMAD4 | 4089 | CTD_human PTGS2 | 5743 | CTD_human FOXP1 | 27086 | CTD_human ARID1A | 8289 | CTD_human CDKN2A | 1029 | CTD_human ELMO1 | 9844 | CTD_human NELL1 | 4745 | CTD_human TLR4 | 7099 | CTD_human DOCK2 | 1794 | CTD_human SPG20 | 23111 | CTD_human CRTC1 | 23373 | CTD_human;GWASCAT BARX1 | 56033 | CTD_human;GWASCAT |
| Inferring Gene | Entrez_id | Symbol | Resource(Total Genes:337) 5243 | ABCB1 | infer 8647 | ABCB11 | infer 5244 | ABCB4 | infer 4363 | ABCC1 | infer 1244 | ABCC2 | infer 8714 | ABCC3 | infer 6833 | ABCC8 | infer 9429 | ABCG2 | infer 25 | ABL1 | infer 84680 | ACCS | infer 126 | ADH1C | infer 127 | ADH4 | infer 196 | AHR | infer 57491 | AHRR | infer 11216 | AKAP10 | infer 10142 | AKAP9 | infer 10327 | AKR1A1 | infer 8644 | AKR1C3 | infer 22977 | AKR7A3 | infer 207 | AKT1 | infer 10840 | ALDH1L1 | infer 8659 | ALDH4A1 | infer 239 | ALOX12 | infer 240 | ALOX5 | infer 317 | APAF1 | infer 324 | APC | infer 328 | APEX1 | infer 405 | ARNT | infer 10973 | ASCC3 | infer 466 | ATF1 | infer 472 | ATM | infer 481 | ATP1B1 | infer 545 | ATR | infer 6790 | AURKA | infer 8313 | AXIN2 | infer 578 | BAK1 | infer 580 | BARD1 | infer 581 | BAX | infer 596 | BCL2 | infer 598 | BCL2L1 | infer 604 | BCL6 | infer 635 | BHMT | infer 637 | BID | infer 330 | BIRC3 | infer 332 | BIRC5 | infer 673 | BRAF | infer 672 | BRCA1 | infer 675 | BRCA2 | infer 56244 | BTNL2 | infer 701 | BUB1B | infer 84254 | CAMKK1 | infer 824 | CAPN2 | infer 10753 | CAPN9 | infer 22900 | CARD8 | infer 843 | CASP10 | infer 835 | CASP2 | infer 836 | CASP3 | infer 837 | CASP4 | infer 840 | CASP7 | infer 841 | CASP8 | infer 842 | CASP9 | infer 875 | CBS | infer 6352 | CCL5 | infer 890 | CCNA2 | infer 891 | CCNB1 | infer 595 | CCND1 | infer 896 | CCND3 | infer 898 | CCNE1 | infer 962 | CD48 | infer 978 | CDA | infer 993 | CDC25A | infer 995 | CDC25C | infer 999 | CDH1 | infer 1010 | CDH12 | infer 1019 | CDK4 | infer 1020 | CDK5 | infer 1021 | CDK6 | infer 1022 | CDK7 | infer 1026 | CDKN1A | infer 1027 | CDKN1B | infer 1029 | CDKN2A | infer 1030 | CDKN2B | infer 8837 | CFLAR | infer 1080 | CFTR | infer 9557 | CHD1L | infer 1111 | CHEK1 | infer 11200 | CHEK2 | infer 23563 | CHST5 | infer 1303 | COL12A1 | infer 1312 | COMT | infer 1401 | CRP | infer 1445 | CSK | infer 1490 | CTGF | infer 1493 | CTLA4 | infer 1524 | CX3CR1 | infer 1586 | CYP17A1 | infer 1588 | CYP19A1 | infer 1543 | CYP1A1 | infer 1544 | CYP1A2 | infer 1545 | CYP1B1 | infer 1591 | CYP24A1 | infer 1594 | CYP27B1 | infer 1562 | CYP2C18 | infer 1559 | CYP2C9 | infer 1571 | CYP2E1 | infer 51302 | CYP39A1 | infer 1576 | CYP3A4 | infer 1577 | CYP3A5 | infer 1603 | DAD1 | infer 8449 | DHX16 | infer 11083 | DIDO1 | infer 1789 | DNMT3B | infer 1806 | DPYD | infer 54935 | DUSP23 | infer 1950 | EGF | infer 1956 | EGFR | infer 79813 | EHMT1 | infer 10919 | EHMT2 | infer 2052 | EPHX1 | infer 8288 | EPX | infer 2064 | ERBB2 | infer 2067 | ERCC1 | infer 2068 | ERCC2 | infer 2071 | ERCC3 | infer 2072 | ERCC4 | infer 2073 | ERCC5 | infer 2074 | ERCC6 | infer 2099 | ESR1 | infer 9156 | EXO1 | infer 2175 | FANCA | infer 355 | FAS | infer 2212 | FCGR2A | infer 2264 | FGFR4 | infer 53834 | FGFRL1 | infer 2321 | FLT1 | infer 2296 | FOXC1 | infer 2356 | FPGS | infer 8836 | GGH | infer 2688 | GH1 | infer 2690 | GHR | infer 2691 | GHRH | infer 2692 | GHRHR | infer 51738 | GHRL | infer 2693 | GHSR | infer 57678 | GPAM | infer 2897 | GRIK1 | infer 2932 | GSK3B | infer 2939 | GSTA2 | infer 2950 | GSTP1 | infer 2954 | GSTZ1 | infer 3000 | GUCY2D | infer 1404 | HAPLN1 | infer 3091 | HIF1A | infer 55662 | HIF1AN | infer 3292 | HSD17B1 | infer 3294 | HSD17B2 | infer 3293 | HSD17B3 | infer 3295 | HSD17B4 | infer 3283 | HSD3B1 | infer 3284 | HSD3B2 | infer 3364 | HUS1 | infer 135458 | HUS1B | infer 29851 | ICOS | infer 3455 | IFNAR2 | infer 3458 | IFNG | infer 3459 | IFNGR1 | infer 3460 | IFNGR2 | infer 3479 | IGF1 | infer 3480 | IGF1R | infer 3481 | IGF2 | infer 3482 | IGF2R | infer 3484 | IGFBP1 | infer 3486 | IGFBP3 | infer 3586 | IL10 | infer 3587 | IL10RA | infer 3592 | IL12A | infer 3593 | IL12B | infer 3594 | IL12RB1 | infer 3596 | IL13 | infer 3600 | IL15 | infer 3601 | IL15RA | infer 55540 | IL17RB | infer 3552 | IL1A | infer 3553 | IL1B | infer 3557 | IL1RN | infer 3558 | IL2 | infer 3562 | IL3 | infer 3565 | IL4 | infer 3566 | IL4R | infer 3567 | IL5 | infer 3569 | IL6 | infer 3570 | IL6R | infer 3636 | INPPL1 | infer 3667 | IRS1 | infer 3673 | ITGA2 | infer 3679 | ITGA7 | infer 3791 | KDR | infer 1316 | KLF6 | infer 3845 | KRAS | infer 9113 | LATS1 | infer 3952 | LEP | infer 3953 | LEPR | infer 3978 | LIG1 | infer 3980 | LIG3 | infer 3981 | LIG4 | infer 4015 | LOX | infer 4033 | LRMP | infer 4049 | LTA | infer 8932 | MBD2 | infer 8930 | MBD4 | infer 4193 | MDM2 | infer 4221 | MEN1 | infer 4255 | MGMT | infer 4292 | MLH1 | infer 4312 | MMP1 | infer 4319 | MMP10 | infer 4323 | MMP14 | infer 4313 | MMP2 | infer 4314 | MMP3 | infer 4318 | MMP9 | infer 64231 | MS4A6A | infer 4436 | MSH2 | infer 4437 | MSH3 | infer 2956 | MSH6 | infer 10232 | MSLN | infer 4522 | MTHFD1 | infer 10797 | MTHFD2 | infer 4524 | MTHFR | infer 4548 | MTR | infer 4552 | MTRR | infer 4595 | MUTYH | infer 10 | NAT2 | infer 4683 | NBN | infer 4790 | NFKB1 | infer 4792 | NFKBIA | infer 4846 | NOS3 | infer 4852 | NPY | infer 1728 | NQO1 | infer 8204 | NRIP1 | infer 4521 | NUDT1 | infer 4968 | OGG1 | infer 56924 | PAK6 | infer 142 | PARP1 | infer 5111 | PCNA | infer 9141 | PDCD5 | infer 5156 | PDGFRA | infer 5159 | PDGFRB | infer 64065 | PERP | infer 5241 | PGR | infer 5286 | PIK3C2A | infer 5289 | PIK3C3 | infer 5290 | PIK3CA | infer 5294 | PIK3CG | infer 5395 | PMS2 | infer 11201 | POLI | infer 5444 | PON1 | infer 10940 | POP1 | infer 5449 | POU1F1 | infer 5467 | PPARD | infer 5468 | PPARG | infer 10891 | PPARGC1A | infer 133522 | PPARGC1B | infer 5578 | PRKCA | infer 5728 | PTEN | infer 9536 | PTGES | infer 5740 | PTGIS | infer 5742 | PTGS1 | infer 5743 | PTGS2 | infer 5781 | PTPN11 | infer 5783 | PTPN13 | infer 56852 | RAD18 | infer 5887 | RAD23B | infer 5888 | RAD51 | infer 5893 | RAD52 | infer 5896 | RAG1 | infer 11186 | RASSF1 | infer 5925 | RB1 | infer 9821 | RB1CC1 | infer 5933 | RBL1 | infer 5979 | RET | infer 5980 | REV3L | infer 8786 | RGS11 | infer 26575 | RGS17 | infer 5997 | RGS2 | infer 8490 | RGS5 | infer 9628 | RGS6 | infer 6240 | RRM1 | infer 5276 | SERPINI2 | infer 6441 | SFTPD | infer 6470 | SHMT1 | infer 6555 | SLC10A2 | infer 85413 | SLC22A16 | infer 9963 | SLC23A1 | infer 9962 | SLC23A2 | infer 2030 | SLC29A1 | infer 4087 | SMAD2 | infer 6696 | SPP1 | infer 6751 | SSTR1 | infer 6752 | SSTR2 | infer 6891 | TAP2 | infer 7015 | TERT | infer 7039 | TGFA | infer 7040 | TGFB1 | infer 7046 | TGFBR1 | infer 7056 | THBD | infer 7057 | THBS1 | infer 7096 | TLR1 | infer 81793 | TLR10 | infer 10333 | TLR6 | infer 3371 | TNC | infer 7124 | TNF | infer 8797 | TNFRSF10A | infer 7132 | TNFRSF1A | infer 116447 | TOP1MT | infer 7157 | TP53 | infer 7158 | TP53BP1 | infer 9540 | TP53I3 | infer 7248 | TSC1 | infer 7249 | TSC2 | infer 7298 | TYMS | infer 54657 | UGT1A4 | infer 54578 | UGT1A6 | infer 54576 | UGT1A8 | infer 7372 | UMPS | infer 7421 | VDR | infer 7428 | VHL | infer 7486 | WRN | infer 7507 | XPA | infer 7508 | XPC | infer 7515 | XRCC1 | infer 7516 | XRCC2 | infer 7517 | XRCC3 | infer 7518 | XRCC4 | infer 7520 | XRCC5 | infer 2547 | XRCC6 | infer 7572 | ZNF24 | infer 57547 | ZNF624 | infer |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:162) 4706 | NDUFAB1 | DISEASES 3675 | ITGA3 | DISEASES 4257 | MGST1 | DISEASES 2067 | ERCC1 | DISEASES 54831 | BEST2 | DISEASES 23645 | PPP1R15A | DISEASES 6790 | AURKA | DISEASES 4605 | MYBL2 | DISEASES 113278 | SLC52A3 | DISEASES 479 | ATP12A | DISEASES 66036 | MTMR9 | DISEASES 1592 | CYP26A1 | DISEASES 4621 | MYH3 | DISEASES 595 | CCND1 | DISEASES 969 | CD69 | DISEASES 1044 | CDX1 | DISEASES 4953 | ODC1 | DISEASES 10459 | MAD2L2 | DISEASES 994 | CDC25B | DISEASES 3860 | KRT13 | DISEASES 3315 | HSPB1 | DISEASES 1890 | TYMP | DISEASES 9518 | GDF15 | DISEASES 6341 | SCO1 | DISEASES 640 | BLK | DISEASES 7111 | TMOD1 | DISEASES 51196 | PLCE1 | DISEASES 8140 | SLC7A5 | DISEASES 999 | CDH1 | DISEASES 506 | ATP5B | DISEASES 495 | ATP4A | DISEASES 27330 | RPS6KA6 | DISEASES 3553 | IL1B | DISEASES 4722 | NDUFS3 | DISEASES 10578 | GNLY | DISEASES 6548 | SLC9A1 | DISEASES 55722 | CEP72 | DISEASES 5243 | ABCB1 | DISEASES 7078 | TIMP3 | DISEASES 2627 | GATA6 | DISEASES 7157 | TP53 | DISEASES 2064 | ERBB2 | DISEASES 207 | AKT1 | DISEASES 49860 | CRNN | DISEASES 154091 | SLC2A12 | DISEASES 1956 | EGFR | DISEASES 202559 | KHDRBS2 | DISEASES 2059 | EPS8 | DISEASES 4154 | MBNL1 | DISEASES 2893 | GRIA4 | DISEASES 3081 | HGD | DISEASES 252969 | NEIL2 | DISEASES 9337 | CNOT8 | DISEASES 10630 | PDPN | DISEASES 2921 | CXCL3 | DISEASES 51705 | EMCN | DISEASES 308 | ANXA5 | DISEASES 2125 | EVPL | DISEASES 3868 | KRT16 | DISEASES 4589 | MUC7 | DISEASES 474 | ATOH1 | DISEASES 598 | BCL2L1 | DISEASES 6870 | TACR3 | DISEASES 8988 | HSPB3 | DISEASES 54360 | CYTL1 | DISEASES 7764 | ZNF217 | DISEASES 4968 | OGG1 | DISEASES 7015 | TERT | DISEASES 2072 | ERCC4 | DISEASES 1163 | CKS1B | DISEASES 3952 | LEP | DISEASES 4482 | MSRA | DISEASES 7298 | TYMS | DISEASES 1960 | EGR3 | DISEASES 55110 | MAGOHB | DISEASES 9370 | ADIPOQ | DISEASES 170572 | HTR3C | DISEASES 286826 | LIN9 | DISEASES 3855 | KRT7 | DISEASES 3953 | LEPR | DISEASES 4601 | MXI1 | DISEASES 2520 | GAST | DISEASES 10057 | ABCC5 | DISEASES 1665 | DHX15 | DISEASES 9547 | CXCL14 | DISEASES 23583 | SMUG1 | DISEASES 54681 | P4HTM | DISEASES 51094 | ADIPOR1 | DISEASES 132660 | LIN54 | DISEASES 2272 | FHIT | DISEASES 8445 | DYRK2 | DISEASES 2305 | FOXM1 | DISEASES 1499 | CTNNB1 | DISEASES 4010 | LMX1B | DISEASES 5879 | RAC1 | DISEASES 8881 | CDC16 | DISEASES 79602 | ADIPOR2 | DISEASES 5887 | RAD23B | DISEASES 9931 | HELZ | DISEASES 1999 | ELF3 | DISEASES 55959 | SULF2 | DISEASES 11076 | TPPP | DISEASES 2882 | GPX7 | DISEASES 800 | CALD1 | DISEASES 2494 | NR5A2 | DISEASES 5743 | PTGS2 | DISEASES 8407 | TAGLN2 | DISEASES 4582 | MUC1 | DISEASES 6281 | S100A10 | DISEASES 1347 | COX7A2 | DISEASES 1806 | DPYD | DISEASES 1647 | GADD45A | DISEASES 4116 | MAGOH | DISEASES 5770 | PTPN1 | DISEASES 64170 | CARD9 | DISEASES 4595 | MUTYH | DISEASES 5225 | PGC | DISEASES 6865 | TACR2 | DISEASES 29988 | SLC2A8 | DISEASES 4524 | MTHFR | DISEASES 94027 | CGB7 | DISEASES 1804 | DPP6 | DISEASES 4609 | MYC | DISEASES 22866 | CNKSR2 | DISEASES 5983 | RFC3 | DISEASES 665 | BNIP3L | DISEASES 54875 | CNTLN | DISEASES 5272 | SERPINB9 | DISEASES 1045 | CDX2 | DISEASES 23600 | AMACR | DISEASES 9037 | SEMA5A | DISEASES 5888 | RAD51 | DISEASES 51280 | GOLM1 | DISEASES 79400 | NOX5 | DISEASES 2877 | GPX2 | DISEASES 5650 | KLK7 | DISEASES 51651 | PTRH2 | DISEASES 5916 | RARG | DISEASES 137872 | ADHFE1 | DISEASES 2115 | ETV1 | DISEASES 1029 | CDKN2A | DISEASES 3491 | CYR61 | DISEASES 2886 | GRB7 | DISEASES 94115 | CGB8 | DISEASES 4588 | MUC6 | DISEASES 9053 | MAP7 | DISEASES 4583 | MUC2 | DISEASES 4585 | MUC4 | DISEASES 8260 | NAA10 | DISEASES 8641 | PCDHGB4 | DISEASES 64641 | EBF2 | DISEASES 7033 | TFF3 | DISEASES 4586 | MUC5AC | DISEASES 7694 | ZNF135 | DISEASES 9971 | NR1H4 | DISEASES 3851 | KRT4 | DISEASES 51741 | WWOX | DISEASES 3316 | HSPB2 | DISEASES 9212 | AURKB | DISEASES 283460 | HNF1A-AS1 | DISEASES 83655 | LINC00208 | DISEASES 114614 | MIR155HG | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 1246 |
|---|---|
| Disease | esophagus adenocarcinoma |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:1) |
| Disease ID | 1246 |
|---|---|
| Disease | esophagus adenocarcinoma |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:144) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs1035142 | 21472143 | 51738 | GHRL | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000542884 | 2011 | ALS2CR12 | 2 | 201288355 | T | G |
| rs1035142 | 21472143 | 342977 | NANOS3 | umls:C0279628 | BeFree | In Kaplan-Meier analyses, rs2070744 of NOS3, rs720321 of BCL2, and rs1035142 of CASP8 were also significantly associated with early onset of EA. | 0.000271442 | 2011 | ALS2CR12 | 2 | 201288355 | T | G |
| rs1035142 | 21472143 | 1588 | CYP19A1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | ALS2CR12 | 2 | 201288355 | T | G |
| rs1035142 | 21472143 | 596 | BCL2 | umls:C0279628 | BeFree | In Kaplan-Meier analyses, rs2070744 of NOS3, rs720321 of BCL2, and rs1035142 of CASP8 were also significantly associated with early onset of EA. | 0.000271442 | 2011 | ALS2CR12 | 2 | 201288355 | T | G |
| rs1035142 | 21472143 | 25 | ABL1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | ALS2CR12 | 2 | 201288355 | T | G |
| rs1035142 | 21472143 | 841 | CASP8 | umls:C0279628 | BeFree | In Kaplan-Meier analyses, rs2070744 of NOS3, rs720321 of BCL2, and rs1035142 of CASP8 were also significantly associated with early onset of EA. | 0.000271442 | 2011 | ALS2CR12 | 2 | 201288355 | T | G |
| rs1035142 | 21472143 | 4323 | MMP14 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | ALS2CR12 | 2 | 201288355 | T | G |
| rs1035142 | 21472143 | 3791 | KDR | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | ALS2CR12 | 2 | 201288355 | T | G |
| rs1035142 | 21472143 | 8797 | TNFRSF10A | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | ALS2CR12 | 2 | 201288355 | T | G |
| rs10419226 | 24121790 | 23373 | CRTC1 | umls:C0279628 | GWASCAT | A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. | 0.240271442 | 2013 | CRTC1 | 19 | 18692362 | T | G |
| rs1042522 | 23735059 | 4193 | MDM2 | umls:C0279628 | BeFree | Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with survival in esophageal adenocarcinoma. | 0.001085767 | 2013 | TP53 | 17 | 7676154 | G | T,C |
| rs1042522 | 23735059 | 7157 | TP53 | umls:C0279628 | BeFree | Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with survival in esophageal adenocarcinoma. | 0.131867498 | 2013 | TP53 | 17 | 7676154 | G | T,C |
| rs1042522 | 20389250 | 7157 | TP53 | umls:C0279628 | BeFree | In subgroup analyses based on pathological type, the Pro variant was significantly associated with an increased esophageal squamous cell carcinoma (ESCC) risk in all four genetic comparison models (ORPro vs. Arg=1.26, 95% CI: 1.08-1.47, POR=0.003; OR Recessive genetic model=1.42, 95% CI: 1.07-1.88, POR=0.015; ORDominant genetic model=1.25, 95% CI: 1.10-1.42, POR=0.001; ORHomozygote model=1.55, 95% CI: 1.14-2.10, POR=0.005), whereas the association between TP53 Arg72Pro polymorphism and esophageal adenocarcinoma risk was still uncertain owing to the limited studies included in this meta-analysis. | 0.131867498 | 2010 | TP53 | 17 | 7676154 | G | T,C |
| rs112431538 | 24077944 | 4089 | SMAD4 | umls:C0279628 | BeFree | Sequencing of OANC1 DNA identified homozygous TP53 missense (c.856G[A, p.E286K)and SMAD4 nonsense (c.1333C[T, p.R445X) mutations.OANC1 are tumorigenic when injected sub-cutaneously into SCID mice and xenografts were positive for columnar, glandular and intestinal epithelial markers commonly expressed in EAC. | 0.121357209 | 2013 | TP53 | 17 | 7673767 | C | T |
| rs112431538 | 24077944 | 7157 | TP53 | umls:C0279628 | BeFree | Sequencing of OANC1 DNA identified homozygous TP53 missense (c.856G[A, p.E286K)and SMAD4 nonsense (c.1333C[T, p.R445X) mutations.OANC1 are tumorigenic when injected sub-cutaneously into SCID mice and xenografts were positive for columnar, glandular and intestinal epithelial markers commonly expressed in EAC. | 0.131867498 | 2013 | TP53 | 17 | 7673767 | C | T |
| rs11540654 | 20389250 | 7157 | TP53 | umls:C0279628 | BeFree | In subgroup analyses based on pathological type, the Pro variant was significantly associated with an increased esophageal squamous cell carcinoma (ESCC) risk in all four genetic comparison models (ORPro vs. Arg=1.26, 95% CI: 1.08-1.47, POR=0.003; OR Recessive genetic model=1.42, 95% CI: 1.07-1.88, POR=0.015; ORDominant genetic model=1.25, 95% CI: 1.10-1.42, POR=0.001; ORHomozygote model=1.55, 95% CI: 1.14-2.10, POR=0.005), whereas the association between TP53 Arg72Pro polymorphism and esophageal adenocarcinoma risk was still uncertain owing to the limited studies included in this meta-analysis. | 0.131867498 | 2010 | TP53 | 17 | 7676040 | C | T,G,A |
| rs11540654 | 23735059 | 7157 | TP53 | umls:C0279628 | BeFree | Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with survival in esophageal adenocarcinoma. | 0.131867498 | 2013 | TP53 | 17 | 7676040 | C | T,G,A |
| rs11540654 | 23735059 | 4193 | MDM2 | umls:C0279628 | BeFree | Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with survival in esophageal adenocarcinoma. | 0.001085767 | 2013 | TP53 | 17 | 7676040 | C | T,G,A |
| rs11775256 | 21472143 | 25 | ABL1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | TNFRSF10A | 8 | 23193972 | C | T |
| rs11775256 | 21472143 | 8797 | TNFRSF10A | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | TNFRSF10A | 8 | 23193972 | C | T |
| rs11775256 | 21472143 | 1588 | CYP19A1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | TNFRSF10A | 8 | 23193972 | C | T |
| rs11775256 | 21472143 | 4323 | MMP14 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | TNFRSF10A | 8 | 23193972 | C | T |
| rs11775256 | 21472143 | 3791 | KDR | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | TNFRSF10A | 8 | 23193972 | C | T |
| rs11775256 | 21472143 | 51738 | GHRL | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000542884 | 2011 | TNFRSF10A | 8 | 23193972 | C | T |
| rs11789015 | 24121790 | 56033 | BARX1 | umls:C0279628 | GWASCAT | A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. | 0.240271442 | 2013 | BARX1 | 9 | 93953746 | A | G |
| rs11941492 | 21751195 | 2321 | FLT1 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000542884 | 2012 | KDR | 4 | 55112043 | C | T |
| rs11941492 | 21472143 | 1588 | CYP19A1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | KDR | 4 | 55112043 | C | T |
| rs11941492 | 21472143 | 25 | ABL1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | KDR | 4 | 55112043 | C | T |
| rs11941492 | 21472143 | 3791 | KDR | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | KDR | 4 | 55112043 | C | T |
| rs11941492 | 21751195 | 5159 | PDGFRB | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | KDR | 4 | 55112043 | C | T |
| rs11941492 | 21751195 | 55662 | HIF1AN | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | KDR | 4 | 55112043 | C | T |
| rs11941492 | 21472143 | 4323 | MMP14 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | KDR | 4 | 55112043 | C | T |
| rs11941492 | 21472143 | 51738 | GHRL | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000542884 | 2011 | KDR | 4 | 55112043 | C | T |
| rs11941492 | 21751195 | 7249 | TSC2 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | KDR | 4 | 55112043 | C | T |
| rs11941492 | 21472143 | 8797 | TNFRSF10A | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | KDR | 4 | 55112043 | C | T |
| rs13181 | 15878910 | 2068 | ERCC2 | umls:C0279628 | BeFree | Significantly reduced frequencies were seen for the XPD Lys751Gln homozygous variant genotype in patients with EADC (OR = 0.24; 95% CI = 0.07-0.88), and for the XRCC1 Arg399Gln homozygous variant genotype in patients with BE (OR = 0.38; 95% CI = 0.12-0.64) and GERD (OR = 0.29; 95% CI = 0.12-0.66). | 0.001357209 | 2005 | ERCC2;KLC3 | 19 | 45351661 | T | A,G |
| rs13181 | 18386788 | 2068 | ERCC2 | umls:C0279628 | BeFree | No associations with EAC or EGJAC were observed with XPD (rs13181). | 0.001357209 | 2008 | ERCC2;KLC3 | 19 | 45351661 | T | A,G |
| rs13337626 | 21751195 | 5159 | PDGFRB | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | TSC2 | 16 | 2075833 | T | C |
| rs13337626 | 21751195 | 7249 | TSC2 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | TSC2 | 16 | 2075833 | T | C |
| rs13337626 | 21751195 | 55662 | HIF1AN | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | TSC2 | 16 | 2075833 | T | C |
| rs13337626 | 21751195 | 2321 | FLT1 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000542884 | 2012 | TSC2 | 16 | 2075833 | T | C |
| rs1501299 | 18398047 | 5468 | PPARG | umls:C0279628 | BeFree | Although several SNPs seemed to be associated with EAC on crude analysis [ADIPOQ (rs1501299), LEP (5'-untranslated region), PPARgamma (H447H), and GHRL (M72L)], effect sizes were modest and none of the associations was significant after correcting for multiple comparisons. | 0.000814326 | 2008 | ADIPOQ;ADIPOQ-AS1 | 3 | 186853334 | G | T |
| rs1501299 | 18398047 | 9370 | ADIPOQ | umls:C0279628 | BeFree | Although several SNPs seemed to be associated with EAC on crude analysis [ADIPOQ (rs1501299), LEP (5'-untranslated region), PPARgamma (H447H), and GHRL (M72L)], effect sizes were modest and none of the associations was significant after correcting for multiple comparisons. | 0.000542884 | 2008 | ADIPOQ;ADIPOQ-AS1 | 3 | 186853334 | G | T |
| rs1501299 | 18398047 | 51738 | GHRL | umls:C0279628 | BeFree | Although several SNPs seemed to be associated with EAC on crude analysis [ADIPOQ (rs1501299), LEP (5'-untranslated region), PPARgamma (H447H), and GHRL (M72L)], effect sizes were modest and none of the associations was significant after correcting for multiple comparisons. | 0.000542884 | 2008 | ADIPOQ;ADIPOQ-AS1 | 3 | 186853334 | G | T |
| rs1695 | 19222528 | 2950 | GSTP1 | umls:C0279628 | BeFree | Our review identified GSTP1(Ile105Val) as a possible risk factor for BE and EAC in Caucasian males. | 0.000814326 | 2009 | GSTP1 | 11 | 67585218 | A | G |
| rs17619601 | 21751195 | 2321 | FLT1 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000542884 | 2012 | FLT1;LOC105370134 | 13 | 28326373 | C | T |
| rs17619601 | 21751195 | 7249 | TSC2 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | FLT1;LOC105370134 | 13 | 28326373 | C | T |
| rs17619601 | 21751195 | 5159 | PDGFRB | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | FLT1;LOC105370134 | 13 | 28326373 | C | T |
| rs17619601 | 21751195 | 55662 | HIF1AN | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | FLT1;LOC105370134 | 13 | 28326373 | C | T |
| rs17625898 | 21751195 | 5159 | PDGFRB | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | FLT1 | 13 | 28358693 | T | A,G |
| rs17625898 | 21751195 | 7249 | TSC2 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | FLT1 | 13 | 28358693 | T | A,G |
| rs17625898 | 21751195 | 55662 | HIF1AN | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | FLT1 | 13 | 28358693 | T | A,G |
| rs17625898 | 21751195 | 2321 | FLT1 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000542884 | 2012 | FLT1 | 13 | 28358693 | T | A,G |
| rs17708574 | 21751195 | 2321 | FLT1 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000542884 | 2012 | PDGFRB | 5 | 150141675 | G | A |
| rs17708574 | 21751195 | 55662 | HIF1AN | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | PDGFRB | 5 | 150141675 | G | A |
| rs17708574 | 21751195 | 7249 | TSC2 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | PDGFRB | 5 | 150141675 | G | A |
| rs17708574 | 21751195 | 5159 | PDGFRB | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | PDGFRB | 5 | 150141675 | G | A |
| rs17757541 | 21472143 | 8797 | TNFRSF10A | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | BCL2 | 18 | 63212453 | C | G,T |
| rs17757541 | 21472143 | 1588 | CYP19A1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | BCL2 | 18 | 63212453 | C | G,T |
| rs17757541 | 21472143 | 4323 | MMP14 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | BCL2 | 18 | 63212453 | C | G,T |
| rs17757541 | 21472143 | 51738 | GHRL | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000542884 | 2011 | BCL2 | 18 | 63212453 | C | G,T |
| rs17757541 | 21472143 | 3791 | KDR | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | BCL2 | 18 | 63212453 | C | G,T |
| rs17757541 | 21472143 | 25 | ABL1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | BCL2 | 18 | 63212453 | C | G,T |
| rs1799793 | 24234258 | 2068 | ERCC2 | umls:C0279628 | BeFree | Our meta-analysis suggested that the ERCC2 Asp312Asn polymorphism might be associated with increased risk of esophageal adenocarcinoma and a protective factor for esophageal squamous cell carcinoma. | 0.001357209 | 2013 | ERCC2 | 19 | 45364001 | C | T |
| rs1805087 | 17726616 | 4548 | MTR | umls:C0279628 | BeFree | Using the restriction fragment length polymorphism (RFLP)-PCR, the prevalence of MTR A2756G and CBS insertion polymorphism was determined in healthy controls (n = 257) and in patients with esophageal squamous cell carcinoma (ESCC) (n = 263), Barrett's esophagus-associated esophageal adenocarcinoma (BC) (n = 89), cardiac carcinoma (CC) (n = 144), or gastric carcinoma (GC) (n = 221) from German Caucasian subjects. | 0.000271442 | 2008 | MTR | 1 | 236885200 | A | G |
| rs2070744 | 21472143 | 8797 | TNFRSF10A | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | NOS3 | 7 | 150992991 | C | T |
| rs2070744 | 21472143 | 596 | BCL2 | umls:C0279628 | BeFree | In Kaplan-Meier analyses, rs2070744 of NOS3, rs720321 of BCL2, and rs1035142 of CASP8 were also significantly associated with early onset of EA. | 0.000271442 | 2011 | NOS3 | 7 | 150992991 | C | T |
| rs2070744 | 21472143 | 3791 | KDR | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | NOS3 | 7 | 150992991 | C | T |
| rs2070744 | 21472143 | 25 | ABL1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | NOS3 | 7 | 150992991 | C | T |
| rs2070744 | 21472143 | 4323 | MMP14 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | NOS3 | 7 | 150992991 | C | T |
| rs2070744 | 21472143 | 51738 | GHRL | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000542884 | 2011 | NOS3 | 7 | 150992991 | C | T |
| rs2070744 | 21472143 | 342977 | NANOS3 | umls:C0279628 | BeFree | In Kaplan-Meier analyses, rs2070744 of NOS3, rs720321 of BCL2, and rs1035142 of CASP8 were also significantly associated with early onset of EA. | 0.000271442 | 2011 | NOS3 | 7 | 150992991 | C | T |
| rs2070744 | 21472143 | 841 | CASP8 | umls:C0279628 | BeFree | In Kaplan-Meier analyses, rs2070744 of NOS3, rs720321 of BCL2, and rs1035142 of CASP8 were also significantly associated with early onset of EA. | 0.000271442 | 2011 | NOS3 | 7 | 150992991 | C | T |
| rs2070744 | 21472143 | 1588 | CYP19A1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | NOS3 | 7 | 150992991 | C | T |
| rs2114039 | 21751195 | 2321 | FLT1 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000542884 | 2012 | NA | 4 | 54226459 | T | C |
| rs2114039 | 21751195 | 55662 | HIF1AN | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | NA | 4 | 54226459 | T | C |
| rs2114039 | 21751195 | 5159 | PDGFRB | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | NA | 4 | 54226459 | T | C |
| rs2114039 | 21751195 | 7249 | TSC2 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | NA | 4 | 54226459 | T | C |
| rs2236302 | 21472143 | 51738 | GHRL | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000542884 | 2011 | MMP14 | 14 | 22843345 | C | G |
| rs2236302 | 21472143 | 1588 | CYP19A1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | MMP14 | 14 | 22843345 | C | G |
| rs2236302 | 21472143 | 8797 | TNFRSF10A | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | MMP14 | 14 | 22843345 | C | G |
| rs2236302 | 21472143 | 25 | ABL1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | MMP14 | 14 | 22843345 | C | G |
| rs2236302 | 21472143 | 4323 | MMP14 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | MMP14 | 14 | 22843345 | C | G |
| rs2236302 | 21472143 | 3791 | KDR | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | MMP14 | 14 | 22843345 | C | G |
| rs2274223 | 23222411 | 51196 | PLCE1 | umls:C0279628 | BeFree | In contrast to the modulation of the risk of ESCC in Asians, it is unlikely that the PLCE1 rs2274223 and RFT2 13042395 SNPs play a role in EAC or ESCC susceptibility in Dutch Caucasians. | 0.000271442 | 2014 | PLCE1 | 10 | 94306584 | A | G |
| rs2295778 | 21751195 | 5159 | PDGFRB | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | HIF1AN | 10 | 100536079 | C | G |
| rs2295778 | 21751195 | 2321 | FLT1 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000542884 | 2012 | HIF1AN | 10 | 100536079 | C | G |
| rs2295778 | 21751195 | 55662 | HIF1AN | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | HIF1AN | 10 | 100536079 | C | G |
| rs2295778 | 21751195 | 7249 | TSC2 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | HIF1AN | 10 | 100536079 | C | G |
| rs2296188 | 21751195 | 2321 | FLT1 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000542884 | 2012 | FLT1;LOC105370134 | 13 | 28319347 | T | C |
| rs2296188 | 21751195 | 7249 | TSC2 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | FLT1;LOC105370134 | 13 | 28319347 | T | C |
| rs2296188 | 21751195 | 55662 | HIF1AN | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | FLT1;LOC105370134 | 13 | 28319347 | T | C |
| rs2296188 | 21751195 | 5159 | PDGFRB | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | FLT1;LOC105370134 | 13 | 28319347 | T | C |
| rs2445762 | 21472143 | 3791 | KDR | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | CYP19A1 | 15 | 51325511 | T | C |
| rs2445762 | 21472143 | 4323 | MMP14 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | CYP19A1 | 15 | 51325511 | T | C |
| rs2445762 | 21472143 | 1588 | CYP19A1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | CYP19A1 | 15 | 51325511 | T | C |
| rs2445762 | 21472143 | 51738 | GHRL | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000542884 | 2011 | CYP19A1 | 15 | 51325511 | T | C |
| rs2445762 | 21472143 | 8797 | TNFRSF10A | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | CYP19A1 | 15 | 51325511 | T | C |
| rs2445762 | 21472143 | 25 | ABL1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | CYP19A1 | 15 | 51325511 | T | C |
| rs25487 | 15878910 | 7515 | XRCC1 | umls:C0279628 | BeFree | The protective effect of the homozygous variant of XRCC1 Arg399Gln for GERD and BE suggests that base excision repair alterations may occur early in progression to EADC, likely in response to GERD-induced endogenous oxidative or inflammatory DNA damage. | 0.001085767 | 2005 | XRCC1 | 19 | 43551574 | T | C |
| rs25487 | 15878910 | 2068 | ERCC2 | umls:C0279628 | BeFree | Significantly reduced frequencies were seen for the XPD Lys751Gln homozygous variant genotype in patients with EADC (OR = 0.24; 95% CI = 0.07-0.88), and for the XRCC1 Arg399Gln homozygous variant genotype in patients with BE (OR = 0.38; 95% CI = 0.12-0.64) and GERD (OR = 0.29; 95% CI = 0.12-0.66). | 0.001357209 | 2005 | XRCC1 | 19 | 43551574 | T | C |
| rs3127075 | 20453000 | 840 | CASP7 | umls:C0279628 | GAD | [In conclusion, this study suggests that the genetic variants of CASP7 and CASP9 in the apoptosis pathway may be important predictive markers for EA susceptibility and that PGR in the sex hormone signaling pathway may be associated with the gender differences in EA risk.] | 0.002638474 | 2010 | CASP7 | 10 | 113712354 | G | C |
| rs377767360 | 24077944 | 4089 | SMAD4 | umls:C0279628 | BeFree | Sequencing of OANC1 DNA identified homozygous TP53 missense (c.856G[A, p.E286K)and SMAD4 nonsense (c.1333C[T, p.R445X) mutations.OANC1 are tumorigenic when injected sub-cutaneously into SCID mice and xenografts were positive for columnar, glandular and intestinal epithelial markers commonly expressed in EAC. | 0.121357209 | 2013 | SMAD4 | 18 | 51076662 | C | T |
| rs377767360 | 24077944 | 7157 | TP53 | umls:C0279628 | BeFree | Sequencing of OANC1 DNA identified homozygous TP53 missense (c.856G[A, p.E286K)and SMAD4 nonsense (c.1333C[T, p.R445X) mutations.OANC1 are tumorigenic when injected sub-cutaneously into SCID mice and xenografts were positive for columnar, glandular and intestinal epithelial markers commonly expressed in EAC. | 0.131867498 | 2013 | SMAD4 | 18 | 51076662 | C | T |
| rs3784262 | 25447851 | 8854 | ALDH1A2 | umls:C0279628 | BeFree | Meta-analysis of all data identified another SNP associated with BE and esophageal adenocarcinoma: rs3784262, within ALDH1A2 (OR = 0.90; 95% CI: 0.87-0.93; P = 3.72 × 10(-9)). | 0.000271442 | 2014 | ALDH1A2 | 15 | 57960908 | T | C |
| rs3794405 | 26014353 | 2321 | FLT1 | umls:C0279628 | BeFree | FLT1 rs3794405 is significantly associated with OS in esophageal adenocarcinoma, whereby each variant allele confers a 45-60% increased risk of mortality. | 0.000542884 | 2015 | FLT1 | 13 | 28432710 | C | T |
| rs386493716 | 15878910 | 7515 | XRCC1 | umls:C0279628 | BeFree | The protective effect of the homozygous variant of XRCC1 Arg399Gln for GERD and BE suggests that base excision repair alterations may occur early in progression to EADC, likely in response to GERD-induced endogenous oxidative or inflammatory DNA damage. | 0.001085767 | 2005 | NA | NA | NA | NA | NA |
| rs386493716 | 15878910 | 2068 | ERCC2 | umls:C0279628 | BeFree | Significantly reduced frequencies were seen for the XPD Lys751Gln homozygous variant genotype in patients with EADC (OR = 0.24; 95% CI = 0.07-0.88), and for the XRCC1 Arg399Gln homozygous variant genotype in patients with BE (OR = 0.38; 95% CI = 0.12-0.64) and GERD (OR = 0.29; 95% CI = 0.12-0.66). | 0.001357209 | 2005 | NA | NA | NA | NA | NA |
| rs397507444 | 21951971 | 4524 | MTHFR | umls:C0279628 | BeFree | Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis. | 0.001085767 | 2012 | MTHFR | 1 | 11794407 | T | G |
| rs397507444 | 23679298 | 4524 | MTHFR | umls:C0279628 | BeFree | In addition, we found that the MTHFR A1298C polymorphism might influence risk ofESCC and EAC in the overall studies. | 0.001085767 | 2014 | MTHFR | 1 | 11794407 | T | G |
| rs4661636 | 20453000 | 842 | CASP9 | umls:C0279628 | GAD | [In conclusion, this study suggests that the genetic variants of CASP7 and CASP9 in the apoptosis pathway may be important predictive markers for EA susceptibility and that PGR in the sex hormone signaling pathway may be associated with the gender differences in EA risk.] | 0.002638474 | 2010 | CASP9 | 1 | 15496566 | C | T |
| rs4740363 | 21472143 | 3791 | KDR | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | ABL1 | 9 | 130753797 | A | G |
| rs4740363 | 21472143 | 8797 | TNFRSF10A | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | ABL1 | 9 | 130753797 | A | G |
| rs4740363 | 21472143 | 1588 | CYP19A1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | ABL1 | 9 | 130753797 | A | G |
| rs4740363 | 21472143 | 51738 | GHRL | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000542884 | 2011 | ABL1 | 9 | 130753797 | A | G |
| rs4740363 | 21472143 | 25 | ABL1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | ABL1 | 9 | 130753797 | A | G |
| rs4740363 | 21472143 | 4323 | MMP14 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | ABL1 | 9 | 130753797 | A | G |
| rs6214 | 24608110 | 3479 | IGF1 | umls:C0279628 | BeFree | The A allele of SNP rs6214 in the IGF-I gene was associated with EAC, and with HNC in women. | 0.001085767 | 2014 | IGF1;LOC105369942 | 12 | 102399791 | C | T |
| rs6898743 | 20403354 | 2690 | GHR | umls:C0279628 | BeFree | GH receptor SNP rs6898743 was associated with EAC (adjusted P = .0112). | 0.000271442 | 2010 | GHR | 5 | 42602390 | C | G |
| rs696217 | 18398047 | 9370 | ADIPOQ | umls:C0279628 | BeFree | Although several SNPs seemed to be associated with EAC on crude analysis [ADIPOQ (rs1501299), LEP (5'-untranslated region), PPARgamma (H447H), and GHRL (M72L)], effect sizes were modest and none of the associations was significant after correcting for multiple comparisons. | 0.000542884 | 2008 | GHRL;GHRLOS | 3 | 10289773 | G | T |
| rs696217 | 21472143 | 4323 | MMP14 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | GHRL;GHRLOS | 3 | 10289773 | G | T |
| rs696217 | 21472143 | 3791 | KDR | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | GHRL;GHRLOS | 3 | 10289773 | G | T |
| rs696217 | 18398047 | 51738 | GHRL | umls:C0279628 | BeFree | Although several SNPs seemed to be associated with EAC on crude analysis [ADIPOQ (rs1501299), LEP (5'-untranslated region), PPARgamma (H447H), and GHRL (M72L)], effect sizes were modest and none of the associations was significant after correcting for multiple comparisons. | 0.000542884 | 2008 | GHRL;GHRLOS | 3 | 10289773 | G | T |
| rs696217 | 21472143 | 8797 | TNFRSF10A | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | GHRL;GHRLOS | 3 | 10289773 | G | T |
| rs696217 | 18398047 | 5468 | PPARG | umls:C0279628 | BeFree | Although several SNPs seemed to be associated with EAC on crude analysis [ADIPOQ (rs1501299), LEP (5'-untranslated region), PPARgamma (H447H), and GHRL (M72L)], effect sizes were modest and none of the associations was significant after correcting for multiple comparisons. | 0.000814326 | 2008 | GHRL;GHRLOS | 3 | 10289773 | G | T |
| rs696217 | 21472143 | 25 | ABL1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | GHRL;GHRLOS | 3 | 10289773 | G | T |
| rs696217 | 21472143 | 51738 | GHRL | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000542884 | 2011 | GHRL;GHRLOS | 3 | 10289773 | G | T |
| rs696217 | 21472143 | 1588 | CYP19A1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | GHRL;GHRLOS | 3 | 10289773 | G | T |
| rs720321 | 21472143 | 4323 | MMP14 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | BCL2 | 18 | 63215417 | G | A |
| rs720321 | 21472143 | 596 | BCL2 | umls:C0279628 | BeFree | In Kaplan-Meier analyses, rs2070744 of NOS3, rs720321 of BCL2, and rs1035142 of CASP8 were also significantly associated with early onset of EA. | 0.000271442 | 2011 | BCL2 | 18 | 63215417 | G | A |
| rs720321 | 21472143 | 841 | CASP8 | umls:C0279628 | BeFree | In Kaplan-Meier analyses, rs2070744 of NOS3, rs720321 of BCL2, and rs1035142 of CASP8 were also significantly associated with early onset of EA. | 0.000271442 | 2011 | BCL2 | 18 | 63215417 | G | A |
| rs720321 | 21472143 | 8797 | TNFRSF10A | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | BCL2 | 18 | 63215417 | G | A |
| rs720321 | 21472143 | 342977 | NANOS3 | umls:C0279628 | BeFree | In Kaplan-Meier analyses, rs2070744 of NOS3, rs720321 of BCL2, and rs1035142 of CASP8 were also significantly associated with early onset of EA. | 0.000271442 | 2011 | BCL2 | 18 | 63215417 | G | A |
| rs720321 | 21472143 | 25 | ABL1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | BCL2 | 18 | 63215417 | G | A |
| rs720321 | 21472143 | 51738 | GHRL | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000542884 | 2011 | BCL2 | 18 | 63215417 | G | A |
| rs720321 | 21472143 | 1588 | CYP19A1 | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | BCL2 | 18 | 63215417 | G | A |
| rs720321 | 21472143 | 3791 | KDR | umls:C0279628 | BeFree | Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). | 0.000271442 | 2011 | BCL2 | 18 | 63215417 | G | A |
| rs7324547 | 21751195 | 2321 | FLT1 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000542884 | 2012 | FLT1 | 13 | 28355470 | A | G |
| rs7324547 | 21751195 | 5159 | PDGFRB | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | FLT1 | 13 | 28355470 | A | G |
| rs7324547 | 21751195 | 55662 | HIF1AN | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | FLT1 | 13 | 28355470 | A | G |
| rs7324547 | 21751195 | 7249 | TSC2 | umls:C0279628 | BeFree | In subsequent logistic regression analyses, interactions between 2 SNPs (rs2295778 of HIF1AN, rs13337626 of TSC2) and GERD, 2 SNPs (rs2295778 of HIF1AN, rs2296188 of VEGFR1) and smoking, and 7 SNPs (rs2114039 of PDGRFA, rs2296188 of VEGFR1, rs11941492 of VEGFR1, rs17708574 of PDGFRB, rs7324547 of VEGFR1, rs17619601 of VEGFR1, and rs17625898 of VEGFR1) and BMI were significantly associated with esophageal adenocarcinoma development (all false-discovery rates ≤0.10). | 0.000271442 | 2012 | FLT1 | 13 | 28355470 | A | G |
| rs917997 | 22664470 | 8807 | IL18RAP | umls:C0279628 | BeFree | These data show a strong association of the IL-18RAP SNP rs917997 locus with BE and EAC and suggestive association of the Barrett's population with the IL-18-607 C/A promoter polymorphism. | 0.000271442 | 2012 | NA | 2 | 102454108 | T | C |
| rs9257809 | 23504527 | 2294 | FOXF1 | umls:C0279628 | BeFree | In conclusion, this study provides evidence that MHC rs9257809 and FOXF1 rs9936833 variants, associated with Barrett's esophagus, also increase ESCC and EAC susceptibility in Caucasians. | 0.000542884 | 2013 | OR5V1 | 6 | 29388554 | A | G |
| rs9936833 | 23504527 | 2294 | FOXF1 | umls:C0279628 | BeFree | In conclusion, this study provides evidence that MHC rs9257809 and FOXF1 rs9936833 variants, associated with Barrett's esophagus, also increase ESCC and EAC susceptibility in Caucasians. | 0.000542884 | 2013 | NA | 16 | 86369512 | C | T |
GWASdb Annotation(Total Genotypes:0) | |
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GWASdb Snp Trait(Total Genotypes:0) | |
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Mapped by lexical matching(Total Items:0) |
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Mapped by homologous gene(Total Items:0) |
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Chemical(Total Drugs:0) | |
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FDA approved drug and dosage information(Total Drugs:0) | |
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FDA labeling changes(Total Drugs:0) | |
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