PedAM

Pediatric Disease Annotations & Medicines


	endophthalmitis

Disease ID	590
Disease	endophthalmitis
Definition	Suppurative inflammation of the tissues of the internal structures of the eye frequently associated with an infection.
Synonym	endophthalmitides endophthalmitis (disorder) endophthalmitis [disease/finding] endophthalmitis, nos eye inflammation eye inflammations eye--inflammation eyes inflammation inflammation eye inflammatory disorder of the eye inflammatory disorder of the eye (disorder) ophthalmia ophthalmia, nos ophthalmias ophthalmitis ophthalmitis (disorder) ophthalmitis -retired- ophthalmitis, nos
Orphanet	ORPHANET:199323
DOID	DOID:4692
UMLS	C0014236
MeSH	D009877
SNOMED-CT	SNOMEDCT_US_2016_09_01:128295000;SNOMEDCT_US_2016_09_01:1847009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:50) C0086543 \| cataract \| 11 C0022568 \| keratitis \| 9 C0035305 \| retinal detachment \| 6 C0017601 \| glaucoma \| 5 C0011847 \| diabetes \| 4 C0032285 \| pneumoniae \| 3 C0025289 \| meningitis \| 3 C0042164 \| uveitis \| 2 C0032285 \| pneumonia \| 2 C0007642 \| cellulitis \| 2 C0008513 \| chorioretinitis \| 2 C0004623 \| bacterial infection \| 2 C0041296 \| tuberculosis \| 2 C0010043 \| corneal ulcer \| 2 C0011849 \| diabetes mellitus \| 2 C0456909 \| vision loss \| 2 C0206178 \| cmv retinitis \| 1 C0039483 \| giant cell arteritis \| 1 C0035335 \| retinoblastoma \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0029443 \| osteomyelitis \| 1 C0032000 \| pituitary adenoma \| 1 C0004623 \| bacterial infections \| 1 C0456909 \| blindness \| 1 C0085669 \| acute leukaemia \| 1 C0023418 \| leukaemia \| 1 C0027947 \| neutropenia \| 1 C0028840 \| ocular hypertension \| 1 C0023449 \| acute lymphoblastic leukemia \| 1 C0338078 \| non-functioning pituitary adenoma \| 1 C0014118 \| endocarditis \| 1 C0042164 \| intraocular inflammation \| 1 C0019348 \| herpes simplex \| 1 C0040553 \| toxocariasis \| 1 C0022595 \| darier's disease \| 1 C0024115 \| lung disease \| 1 C0020538 \| hypertension \| 1 C0035305 \| retinal detachments \| 1 C0042166 \| intermediate uveitis \| 1 C0023418 \| leukemia \| 1 C0038034 \| sporotrichosis \| 1 C0376545 \| hematologic malignancy \| 1 C0854486 \| functioning pituitary adenoma \| 1 C0519030 \| klebsiella pneumonia \| 1 C0149507 \| orbital cellulitis \| 1 C0015397 \| ocular disease \| 1 C0085437 \| bacterial meningitis \| 1 C0036416 \| scleritis \| 1 C0206062 \| interstitial lung disease \| 1 C0020302 \| congenital glaucoma \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:99) 4257 \| MGST1 \| DISEASES 4185 \| ADAM11 \| DISEASES 973 \| CD79A \| DISEASES 7392 \| USF2 \| DISEASES 6348 \| CCL3 \| DISEASES 4353 \| MPO \| DISEASES 2822 \| GPLD1 \| DISEASES 84329 \| HVCN1 \| DISEASES 5199 \| CFP \| DISEASES 968 \| CD68 \| DISEASES 64428 \| NARFL \| DISEASES 6538 \| SLC6A11 \| DISEASES 1401 \| CRP \| DISEASES 23175 \| LPIN1 \| DISEASES 3569 \| IL6 \| DISEASES 27348 \| TOR1B \| DISEASES 7097 \| TLR2 \| DISEASES 6121 \| RPE65 \| DISEASES 27130 \| INVS \| DISEASES 25939 \| SAMHD1 \| DISEASES 10133 \| OPTN \| DISEASES 3553 \| IL1B \| DISEASES 55717 \| WDR11 \| DISEASES 25793 \| FBXO7 \| DISEASES 6687 \| SPG7 \| DISEASES 8915 \| BCL10 \| DISEASES 54856 \| GON4L \| DISEASES 319100 \| TAAR6 \| DISEASES 7082 \| TJP1 \| DISEASES 60558 \| GUF1 \| DISEASES 6529 \| SLC6A1 \| DISEASES 3099 \| HK2 \| DISEASES 1409 \| CRYAA \| DISEASES 213 \| ALB \| DISEASES 1672 \| DEFB1 \| DISEASES 282974 \| STK32C \| DISEASES 6236 \| RRAD \| DISEASES 124872 \| B4GALNT2 \| DISEASES 3627 \| CXCL10 \| DISEASES 56246 \| MRAP \| DISEASES 157570 \| ESCO2 \| DISEASES 5340 \| PLG \| DISEASES 1427 \| CRYGS \| DISEASES 56667 \| MUC13 \| DISEASES 3642 \| INSM1 \| DISEASES 54714 \| CNGB3 \| DISEASES 5551 \| PRF1 \| DISEASES 10892 \| MALT1 \| DISEASES 3996 \| LLGL1 \| DISEASES 2242 \| FES \| DISEASES 8398 \| PLA2G6 \| DISEASES 6540 \| SLC6A13 \| DISEASES 3329 \| HSPD1 \| DISEASES 5275 \| SERPINB13 \| DISEASES 25870 \| SUMF2 \| DISEASES 6590 \| SLPI \| DISEASES 3146 \| HMGB1 \| DISEASES 5170 \| PDPK1 \| DISEASES 3638 \| INSIG1 \| DISEASES 9218 \| VAPA \| DISEASES 766 \| CA7 \| DISEASES 9600 \| PITPNM1 \| DISEASES 55124 \| PIWIL2 \| DISEASES 6539 \| SLC6A12 \| DISEASES 4860 \| PNP \| DISEASES 7096 \| TLR1 \| DISEASES 2058 \| EPRS \| DISEASES 5788 \| PTPRC \| DISEASES 1660 \| DHX9 \| DISEASES 26002 \| MOXD1 \| DISEASES 103 \| ADAR \| DISEASES 7390 \| UROS \| DISEASES 64170 \| CARD9 \| DISEASES 7422 \| VEGFA \| DISEASES 10919 \| EHMT2 \| DISEASES 1676 \| DFFA \| DISEASES 5212 \| VIT \| DISEASES 9467 \| SH3BP5 \| DISEASES 2875 \| GPT \| DISEASES 64115 \| C10orf54 \| DISEASES 26471 \| NUPR1 \| DISEASES 10581 \| IFITM2 \| DISEASES 3778 \| KCNMA1 \| DISEASES 55636 \| CHD7 \| DISEASES 3776 \| KCNK2 \| DISEASES 4125 \| MAN2B1 \| DISEASES 7124 \| TNF \| DISEASES 3491 \| CYR61 \| DISEASES 4615 \| MYD88 \| DISEASES 5923 \| RASGRF1 \| DISEASES 3850 \| KRT3 \| DISEASES 3712 \| IVD \| DISEASES 8801 \| SUCLG2 \| DISEASES 2920 \| CXCL2 \| DISEASES 4168 \| MCF2 \| DISEASES 83695 \| RHNO1 \| DISEASES 4065 \| LY75 \| DISEASES 104355217 \| ERICD \| DISEASES 677767 \| SCARNA7 \| DISEASES
Locus	(Waiting for update.)

Disease ID	590
Disease	endophthalmitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:35) HP:0000518 \| Cataract \| 10 HP:0100523 \| Hepatic abscess \| 10 HP:0000491 \| Corneal inflammation \| 8 HP:0000572 \| Visual loss \| 6 HP:0000541 \| Detached retina \| 6 HP:0007663 \| Central visual loss \| 6 HP:0000501 \| Glaucoma \| 5 HP:0012424 \| Chorioretinitis \| 2 HP:0012804 \| Corneal ulceration \| 2 HP:0100806 \| Sepsis \| 2 HP:0012531 \| Pain \| 2 HP:0002090 \| Pneumonia \| 2 HP:0100658 \| Bacterial infection of skin \| 2 HP:0000819 \| Diabetes mellitus \| 2 HP:0000554 \| Uveitis \| 2 HP:0001287 \| Meningitis \| 2 HP:0200026 \| Ocular pain \| 1 HP:0100533 \| Ocular inflammation \| 1 HP:0001909 \| Leukemia \| 1 HP:0012124 \| Intermediate uveitis \| 1 HP:0007906 \| Increased intraocular pressure \| 1 HP:0000505 \| Poor vision \| 1 HP:0030049 \| Brain abscess \| 1 HP:0009919 \| Retinoblastoma \| 1 HP:0002754 \| Bone infection \| 1 HP:0002893 \| Pituitary adenoma \| 1 HP:0001141 \| Severe visual impairment \| 1 HP:0006721 \| Acute lymphocytic leukemia \| 1 HP:0006530 \| Interstitial lung disease \| 1 HP:0100014 \| Macular pucker \| 1 HP:0000822 \| Hypertension \| 1 HP:0000618 \| Blindness \| 1 HP:0000010 \| Frequent urinary tract infections \| 1 HP:0001087 \| Childhood glaucoma \| 1 HP:0100532 \| Scleritis \| 1

Disease ID	590
Disease	endophthalmitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:3) C2707258 \| infections C0023885 \| liver abscess C0014118 \| endocarditis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0023885 \| liver abscess \| 10 C0021311 \| infections \| 5

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:4)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0014236	amikacin	D000583	37517-28-5	endophthalmitis	MESH:D009877	therapeutic	9199746
C0014236	cyclophosphamide	D003520	50-18-0	endophthalmitis	MESH:D009877	therapeutic	11232733
C0014236	liposomal amphotericin b	C068538	-	endophthalmitis	MESH:D009877	therapeutic	19320385
C0014236	vancomycin	D014640	1404-90-6	endophthalmitis	MESH:D009877	therapeutic	9199746

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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