PedAM

Pediatric Disease Annotations & Medicines


	dysphagia

Disease ID	1277
Disease	dysphagia
Definition	Difficulty in SWALLOWING which may result from neuromuscular disorder or mechanical obstruction. Dysphagia is classified into two distinct types: oropharyngeal dysphagia due to malfunction of the PHARYNX and UPPER ESOPHAGEAL SPHINCTER; and esophageal dysphagia due to malfunction of the ESOPHAGUS.
Synonym	[d]difficulty in swallowing [d]difficulty in swallowing (context-dependent category) [d]difficulty in swallowing (situation) [d]dysphagia [d]dysphagia (context-dependent category) [d]dysphagia (situation) [d]dysphagia nos [d]dysphagia nos (context-dependent category) [d]dysphagia nos (situation) can't get food down cannot get food down deglutition dis deglutition disorder deglutition disorders deglutition disorders [disease/finding] difficult swallowing difficulties swallowing difficulty in swallowing difficulty in swallowing nos difficulty swallowing difficulty swallowing (finding) disorder deglutition disorders, deglutition dysphagia (disorder) dysphagia nos dysphagia, nos dysphagia, unspecified dysphagias poor swallowing swallowing difficult swallowing difficulties swallowing difficulties (dysphagia) swallowing difficulty swallowing dis swallowing disorder swallowing disorders
ICD10	ICD10CM:R13.10
UMLS	C0011168
MeSH	D003680
SNOMED-CT	SNOMEDCT_US_2016_09_01:288939007;SNOMEDCT_US_2016_09_01:40739000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:184) C0032285 \| pneumonia \| 24 C0032290 \| aspiration pneumonia \| 21 C0030567 \| parkinson's disease \| 20 C0014859 \| esophageal cancer \| 19 C0162429 \| malnutrition \| 17 C0002736 \| amyotrophic lateral sclerosis \| 8 C0026769 \| multiple sclerosis \| 8 C0014868 \| esophagitis \| 7 C0341106 \| eosinophilic esophagitis \| 7 C0152018 \| esophageal carcinoma \| 7 C0020498 \| diffuse idiopathic skeletal hyperostosis \| 6 C0014848 \| achalasia \| 6 C0521542 \| brainstem stroke \| 5 C0497327 \| dementia \| 5 C0003125 \| anorexia nervosa \| 4 C0007785 \| cerebral infarction \| 4 C0242429 \| sore throat \| 4 C0014852 \| esophageal disease \| 4 C0007785 \| cerebral infarct \| 4 C0027765 \| neurological disorder \| 4 C0007789 \| cerebral palsy \| 3 C0027868 \| neuromuscular disease \| 3 C0020179 \| huntington's disease \| 3 C0020492 \| hyperostosis \| 3 C0030567 \| parkinson disease \| 3 C0442874 \| neuropathy \| 3 C0013264 \| duchenne muscular dystrophy \| 3 C0242379 \| lung cancer \| 3 C0020498 \| forestier's disease \| 3 C0018021 \| thyroid enlargement \| 3 C0026640 \| oral cancer \| 3 C1956089 \| osteophytes \| 3 C0546837 \| oesophageal cancer \| 2 C0028064 \| niemann-pick disease \| 2 C0026848 \| muscular diseases \| 2 C0027765 \| neurological disease \| 2 C0026896 \| myasthenia gravis \| 2 C0018991 \| hemiplegia \| 2 C0014858 \| esophageal motility disorders \| 2 C0017921 \| pompe disease \| 2 C1956089 \| osteophytosis \| 2 C0162429 \| malnourished \| 2 C0014859 \| esophageal tumors \| 2 C0027121 \| myositis \| 2 C0014527 \| epidermolysis bullosa \| 2 C0027765 \| neurologic disorder \| 2 C0042075 \| urological disorders \| 2 C0011570 \| depression \| 2 C0041296 \| tuberculosis \| 2 C0014852 \| oesophageal disease \| 2 C0027868 \| neuromuscular diseases \| 2 C0004134 \| ataxia \| 2 C0015464 \| facial palsy \| 2 C0238190 \| inclusion body myositis \| 2 C0238301 \| nasopharyngeal carcinoma \| 2 C0014859 \| esophageal tumor \| 2 C0393571 \| multiple system atrophy \| 2 C0026846 \| muscle atrophy \| 2 C0152025 \| polyneuropathy \| 2 C0027765 \| neurological disorders \| 2 C0270952 \| oculopharyngeal muscular dystrophy \| 2 C0236642 \| pick disease \| 2 C0031347 \| pharyngeal cancer \| 2 C0003537 \| aphasia \| 2 C0085084 \| motor neuron disease \| 1 C0026848 \| myopathy \| 1 C0018799 \| heart disease \| 1 C0019291 \| hiatus hernia \| 1 C0686353 \| limb-girdle muscular dystrophy \| 1 C0025289 \| meningitis \| 1 C0023827 \| liposarcoma \| 1 C0014850 \| esophageal atresia \| 1 C0014869 \| reflux oesophagitis \| 1 C0017168 \| esophageal reflux disease \| 1 C0019202 \| wilson's disease \| 1 C0020498 \| forestier disease \| 1 C0026847 \| spinal muscular atrophy \| 1 C0038358 \| gastric ulcers \| 1 C0015464 \| facial nerve palsy \| 1 C0006109 \| chronic enceph \| 1 C0040583 \| tracheal stenosis \| 1 C0011633 \| dermatomyositis \| 1 C0079293 \| epidermolysis bullosa acquisita \| 1 C0524851 \| neurodegenerative disease \| 1 C0152018 \| oesophageal carcinoma \| 1 C0003460 \| anuria \| 1 C0009782 \| connective tissue disease \| 1 C0021053 \| immune disorders \| 1 C0005745 \| ptosis \| 1 C0020550 \| hyperthyroidism \| 1 C0042109 \| hives \| 1 C0030442 \| bulbar palsy \| 1 C0013384 \| dyskinesia \| 1 C0016719 \| friedreich ataxia \| 1 C0014867 \| esophageal varices \| 1 C0392549 \| infantile cerebral palsy \| 1 C0032371 \| polio \| 1 C0029443 \| osteomyelitis \| 1 C0752347 \| lewy body dementia \| 1 C0153398 \| hypopharyngeal cancer \| 1 C0020676 \| hypothyroid \| 1 C0032285 \| pneumoniae \| 1 C0151311 \| cranial nerve palsy \| 1 C0001403 \| addison's disease \| 1 C0004096 \| asthma \| 1 C0043019 \| lateral medullary syndrome \| 1 C0546837 \| esophageal cancers \| 1 C0041316 \| tuberculous lymphadenitis \| 1 C1145670 \| respiratory failure \| 1 C0011269 \| vascular dementia \| 1 C0007222 \| cardiovascular disorders \| 1 C0015469 \| facial paralysis \| 1 C0037315 \| sleep apnea \| 1 C0023418 \| leukemia \| 1 C0002395 \| alzheimer's disease \| 1 C0035229 \| respiratory insufficiency \| 1 C1333990 \| lynch syndrome \| 1 C0026846 \| muscular atrophy \| 1 C0042769 \| virus infection \| 1 C0017675 \| glossitis \| 1 C0524851 \| neurodegenerative diseases \| 1 C0020498 \| diffuse idiopathic skeletal hyperostosis (dish) \| 1 C0027873 \| neuromyelitis optica \| 1 C0314719 \| dry eye \| 1 C0393851 \| critical illness polyneuropathy \| 1 C0037315 \| sleep apnea syndrome \| 1 C0037928 \| myelopathy \| 1 C0024408 \| machado-joseph disease \| 1 C0007134 \| renal cell carcinoma \| 1 C0037315 \| sleep-disordered breathing \| 1 C0018021 \| goiter \| 1 C0036341 \| schizophrenia \| 1 C0024623 \| gastric cancer \| 1 C0024408 \| spinocerebellar ataxia type 3 \| 1 C0006111 \| brain disorders \| 1 C0752347 \| dementia with lewy bodies \| 1 C0043037 \| verrucous lesion \| 1 C0007758 \| cerebellar ataxia \| 1 C0153382 \| oropharyngeal cancer \| 1 C0021053 \| immune disorder \| 1 C0011615 \| atopic dermatitis \| 1 C0014868 \| oesophagitis \| 1 C0033790 \| pseudobulbar palsy \| 1 C0015230 \| rash \| 1 C0018024 \| retrosternal goiter \| 1 C0007137 \| squamous cell carcinoma \| 1 C0018378 \| guillain-barre syndrome \| 1 C2363927 \| brain stem stroke \| 1 C0004936 \| mental disorders \| 1 C0031039 \| pericardial effusion \| 1 C0023448 \| lymphocytic leukemia \| 1 C0014858 \| esophageal dysmotility \| 1 C0024205 \| lymphadenitis \| 1 C0162429 \| nutritional deficiency \| 1 C0520679 \| obstructive sleep apnea \| 1 C0080040 \| post-polio syndrome \| 1 C0003467 \| anxiety \| 1 C0007113 \| rectal carcinoma \| 1 C0039614 \| tetanus \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0519030 \| klebsiella pneumonia \| 1 C0027121 \| inflammatory myopathy \| 1 C0024408 \| joseph disease \| 1 C0013421 \| dystonia \| 1 C0024623 \| gastric cancers \| 1 C0006111 \| brain disorder \| 1 C0025164 \| megaesophagus \| 1 C0032285 \| pneumonias \| 1 C0038358 \| gastric ulcer \| 1 C0042373 \| vascular disorder \| 1 C0042373 \| vascular disorders \| 1 C0153349 \| tongue cancer \| 1 C0279628 \| esophageal adenocarcinoma \| 1 C0006109 \| chronic encephalopathy \| 1 C0030442 \| bulbar paralysis \| 1 C0162429 \| poor nutrition \| 1 C0520679 \| obstructive sleep apnea syndrome \| 1 C0042345 \| varices \| 1 C0027765 \| neurologic disorders \| 1 C0009402 \| colorectal carcinoma \| 1 C0026850 \| muscular dystrophy \| 1 C0024248 \| lymphocele \| 1 C0036202 \| sarcoidosis \| 1 C0017168 \| gastro-oesophageal reflux disease \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) TSEN2 \| 80746 \| CTD_human TSEN34 \| 79042 \| CTD_human MEGF10 \| 84466 \| CTD_human TSEN54 \| 283989 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1277
Disease	dysphagia
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:151) HP:0001297 \| Cerebral vascular events \| 61 HP:0002835 \| Aspiration \| 52 HP:0012531 \| Pain \| 29 HP:0002090 \| Pneumonia \| 24 HP:0011951 \| Aspiration pneumonia \| 20 HP:0004395 \| Malnutrition \| 17 HP:0001824 \| Weight loss \| 13 HP:0002043 \| Esophageal stricture \| 11 HP:0030731 \| Carcinoma \| 11 HP:0001944 \| Dehydration \| 10 HP:0100633 \| Inflammation of the esophagus \| 8 HP:0007354 \| Amyotrophic lateral sclerosis \| 8 HP:0002664 \| Neoplasia \| 7 HP:0011459 \| Esophageal carcinoma \| 7 HP:0002020 \| Heartburn \| 6 HP:0002571 \| Achalasia \| 6 HP:0000726 \| Dementia \| 5 HP:0012735 \| Coughing \| 5 HP:0100749 \| Thoracic pain \| 5 HP:0001283 \| Bulbar palsies \| 5 HP:0002039 \| Anorexia \| 4 HP:0001260 \| Dysarthric speech \| 4 HP:0003470 \| Inability to move \| 4 HP:0010450 \| Narrowing of the esophagus \| 4 HP:0002094 \| Dyspnea \| 4 HP:0002018 \| Nausea \| 3 HP:0001945 \| Fever \| 3 HP:0010628 \| Facial palsy, unilateral or bilateral \| 3 HP:0003473 \| Fatigable weakness \| 3 HP:0003202 \| Neurogenic muscle atrophy, especially in the lower limbs \| 3 HP:0002172 \| Postural instability \| 3 HP:0100774 \| Hyperostosis \| 3 HP:0100021 \| Cerebral palsy \| 3 HP:0000217 \| Dry mouth syndrome \| 3 HP:0012532 \| Chronic pain \| 2 HP:0030833 \| Neck pain \| 2 HP:0000716 \| Depression \| 2 HP:0002381 \| Aphasia \| 2 HP:0000605 \| Supranuclear gaze paralysis \| 2 HP:0001609 \| Hoarseness \| 2 HP:0100315 \| Lewy bodies \| 2 HP:0001324 \| Muscular weakness \| 2 HP:0000508 \| Drooping upper eyelid \| 2 HP:0002013 \| Emesis \| 2 HP:0012473 \| Wasting of the tongue \| 2 HP:0001251 \| Ataxia \| 2 HP:0100614 \| Muscle inflammation \| 2 HP:0001611 \| Hypernasal speech \| 2 HP:0002781 \| Upper airway obstruction \| 2 HP:0100751 \| Esophageal neoplasm \| 2 HP:0002301 \| Hemiplegia \| 2 HP:0002015 \| Swallowing difficulty \| 2 HP:0007099 \| Arnold Chiari type I malformation \| 2 HP:0002027 \| Abdominal pain \| 2 HP:0005240 \| Esophageal obstruction \| 2 HP:0001271 \| Polyneuropathy \| 2 HP:0002200 \| Pseudobulbar symptoms \| 1 HP:0001649 \| Tachycardia \| 1 HP:0012074 \| Adie pupil \| 1 HP:0002777 \| Tracheal stenosis \| 1 HP:0200136 \| Oral-pharyngeal dysphagia \| 1 HP:0002840 \| Lymphadenitis \| 1 HP:0009071 \| Inflammatory myopathy \| 1 HP:0003781 \| Oversalivation \| 1 HP:0002140 \| Ischemic stroke \| 1 HP:0002878 \| Respiratory failure \| 1 HP:0000836 \| Overactive thyroid \| 1 HP:0100730 \| Bronchogenic cyst \| 1 HP:0001618 \| Dysphonia \| 1 HP:0002170 \| Intracranial hemorrhage \| 1 HP:0000365 \| Hearing impairment \| 1 HP:0001640 \| Increased heart size \| 1 HP:0012034 \| Liposarcoma \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0007024 \| Pseudobulbar palsy \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0010535 \| Sleep apnea \| 1 HP:0002273 \| Tetraparesis \| 1 HP:0002104 \| Absence of spontaneous respiration \| 1 HP:0002307 \| Sialorrhea \| 1 HP:0002067 \| Bradykinesia \| 1 HP:0001047 \| Atopic dermatitis \| 1 HP:0003690 \| Limb weakness \| 1 HP:0002754 \| Bone infection \| 1 HP:0002647 \| Aortic dissection \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0002099 \| Asthma \| 1 HP:0002196 \| Myelopathy \| 1 HP:0002017 \| Nausea and vomiting \| 1 HP:0003560 \| Muscular dystrophy \| 1 HP:0030812 \| Tonsillar hypertrophy \| 1 HP:0000969 \| Dropsy \| 1 HP:0100660 \| Dyskinesis \| 1 HP:0005348 \| Inspiratory stridor \| 1 HP:0002592 \| Stomach ulcer \| 1 HP:0001909 \| Leukemia \| 1 HP:0001605 \| Vocal cord paralysis \| 1 HP:0000739 \| Anxiety \| 1 HP:0000155 \| Oral ulcer \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0002366 \| Lower motor neuron disease \| 1 HP:0000961 \| Cyanosis \| 1 HP:0011590 \| Double aortic arch \| 1 HP:0007209 \| Facial paresis \| 1 HP:0001342 \| Intracerebral hemorrhage \| 1 HP:0003198 \| Myopathic changes \| 1 HP:0002317 \| Unsteady walk \| 1 HP:0001025 \| Hives \| 1 HP:0006785 \| Limb-girdle muscular dystrophy \| 1 HP:0001601 \| Laryngomalacia \| 1 HP:0100594 \| Esophageal web \| 1 HP:0008207 \| Addison's disease \| 1 HP:0003326 \| Muscle pain \| 1 HP:0100519 \| Anuria \| 1 HP:0100753 \| Schizophrenia \| 1 HP:0007269 \| Spinal muscle wasting \| 1 HP:0000853 \| Goitre \| 1 HP:0002093 \| progressive respiratory failure \| 1 HP:0012390 \| Anal fissure \| 1 HP:0001285 \| Spastic tetraparesis \| 1 HP:0001508 \| Weight faltering \| 1 HP:0012126 \| Gastric cancer \| 1 HP:0001287 \| Meningitis \| 1 HP:0000211 \| Trismus \| 1 HP:0001880 \| Eosinophilia \| 1 HP:0003270 \| Distended abdomen \| 1 HP:0002870 \| Obstructive sleep apnea \| 1 HP:0001698 \| Pericardial effusions \| 1 HP:0100022 \| Movement disorder \| 1 HP:0002315 \| Headaches \| 1 HP:0000511 \| Vertical supranuclear gaze palsy \| 1 HP:0005584 \| Renal cell carcinoma \| 1 HP:0002098 \| Respiratory distress \| 1 HP:0000220 \| Velopharyngeal insufficiency \| 1 HP:0007340 \| Lower limb weakness \| 1 HP:0005110 \| Atrial fibrillation \| 1 HP:0006824 \| Cranial nerve palsy \| 1 HP:0002032 \| Esophageal atresia \| 1 HP:0002483 \| Bulbar signs \| 1 HP:0002948 \| Fusion of vertebral bodies \| 1 HP:0030692 \| Brain tumor \| 1 HP:0001631 \| Atria septal defect \| 1 HP:0001742 \| Obstruction of nose \| 1 HP:0012879 \| Ejaculatory incompetence \| 1 HP:0002036 \| Hiatus hernia \| 1 HP:0001332 \| Dystonia \| 1 HP:0002100 \| Recurrent aspiration pneumonia \| 1 HP:0011947 \| Respiratory infection \| 1 HP:0000206 \| Inflammation of the tongue \| 1 HP:0002321 \| Vertigo \| 1 HP:0001257 \| Spasticity \| 1

Disease ID	1277
Disease	dysphagia
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:17) C0038454 \| stroke \| 60 C0030193 \| pain \| 28 C0032285 \| pneumonia \| 23 C0032290 \| aspiration pneumonia \| 20 C0162429 \| malnutrition \| 17 C0002736 \| amyotrophic lateral sclerosis \| 8 C0152018 \| esophageal carcinoma \| 7 C0014848 \| achalasia \| 6 C0221163 \| motor disorders \| 3 C0426768 \| o sign \| 3 C1956089 \| osteophytes \| 3 C1839611 \| n syndrome \| 2 C0422833 \| ent symptoms \| 2 C0014858 \| esophageal dysmotility \| 1 C0014852 \| esophageal disorders \| 1 C2004632 \| aberrant right subclavian artery \| 1 C0587246 \| limb weakness \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs121912438	19495873	6647	SOD1	umls:C0011168	BeFree	We recently established that the SOD1-G93A transgenic mouse is a suitable model for oral-stage dysphagia in amyotrophic lateral sclerosis (ALS).	0.000542884	2010	SOD1	21	31667299	G	C
rs2267437	19251090	2547	XRCC6	umls:C0011168	GAD	[Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes.]	0.002367032	2009	XRCC6;DESI1	22	41620695	C	G
rs861539	19251090	7517	XRCC3	umls:C0011168	GAD	[Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes.]	0.002367032	2009	KLC1;XRCC3	14	103699416	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:20)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0011168	chlorpromazine	D002746	50-53-3	deglutition disorders	MESH:D003680	marker/mechanism	4247303
C0011168	cisapride	D020117	81098-60-4	deglutition disorders	MESH:D003680	marker/mechanism	7723193
C0011168	clozapine	D003024	5786-21-0	deglutition disorders	MESH:D003680	marker/mechanism	7962689
C0011168	digoxin	D004077	20830-75-5	deglutition disorders	MESH:D003680	marker/mechanism	2039889
C0011168	fosinopril	D017328	98048-97-6	deglutition disorders	MESH:D003680	marker/mechanism	17245835
C0011168	gemcitabine	C056507	103882-84-4	deglutition disorders	MESH:D003680	marker/mechanism	9500323
C0011168	haloperidol	D006220	52-86-8	deglutition disorders	MESH:D003680	marker/mechanism	17024549
C0011168	haloperidol	D006220	52-86-8	deglutition disorders	MESH:D003680	therapeutic	17484951
C0011168	lorazepam	D008140	846-49-1	deglutition disorders	MESH:D003680	therapeutic	17484951
C0011168	methotrexate	D008727	1959/5/2	deglutition disorders	MESH:D003680	marker/mechanism	16314998
C0011168	methysergide	D008784	361-37-5	deglutition disorders	MESH:D003680	marker/mechanism	6807440
C0011168	omeprazole	D009853	73590-58-6	deglutition disorders	MESH:D003680	therapeutic	10566755
C0011168	prochlorperazine	D011346	58-38-8	deglutition disorders	MESH:D003680	marker/mechanism	20486582
C0011168	pyridoxine	D011736	-	deglutition disorders	MESH:D003680	therapeutic	20167372
C0011168	tacrolimus	D016559	109581-93-3	deglutition disorders	MESH:D003680	marker/mechanism	12819864
C0011168	tetrabenazine	D013747	58-46-8	deglutition disorders	MESH:D003680	marker/mechanism	132600
C0011168	thiethylperazine	D013847	1420-55-9	deglutition disorders	MESH:D003680	marker/mechanism	16101941
C0011168	valproic acid	D014635	99-66-1	deglutition disorders	MESH:D003680	marker/mechanism	20204907
C0011168	vincristine	D014750	-	deglutition disorders	MESH:D003680	marker/mechanism	10942065
C0011168	ziprasidone	C092292	146939-27-7	deglutition disorders	MESH:D003680	marker/mechanism	18305296

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)