PedAM

Pediatric Disease Annotations & Medicines


	duodenal ulcer

Disease ID	191
Disease	duodenal ulcer
Definition	A PEPTIC ULCER located in the DUODENUM.
Synonym	common duodenal ulcer common duodenal ulcer (disorder) common duodenal ulcer (disorder) [ambiguous] common duodenal ulcer, nos du - duodenal ulcer dud - duodenal ulcer disease duodenal ulcer (diagnosis) duodenal ulcer (disorder) duodenal ulcer [disease/finding] duodenal ulcer disease duodenal ulcer disease (disorder) duodenal ulcer disease, nos duodenal ulcer nos duodenal ulcer nos (disorder) duodenal ulcer, nos duodenal ulceration duodenal ulcers duodenum ulcer duodenum ulcers duodenum, peptic ulcer duodenum, ulcer peptic ulcer of duodenum peptic ulcer of duodenum (disorder) peptic ulcer of duodenum, nos ulcer duodenal ulcer, duodenal ulcers, duodenal unspecified duodenal ulcer unspecified duodenal ulcer (disorder) unspecified duodenal ulcer nos unspecified duodenal ulcer nos (disorder)
DOID	DOID:1724
UMLS	C0013295
MeSH	D004381
SNOMED-CT	SNOMEDCT_US_2016_09_01:367474008;SNOMEDCT_US_2016_09_01:51868009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:45) C0017152 \| gastritis \| 5 C0030305 \| pancreatitis \| 4 C0034194 \| pyloric stenosis \| 3 C0038358 \| gastric ulcer \| 3 C0031154 \| peritonitis \| 3 C0024623 \| gastric cancer \| 3 C0017178 \| gastrointestinal disease \| 2 C0021831 \| intestinal disease \| 2 C0001339 \| acute pancreatitis \| 2 C0014868 \| esophagitis \| 2 C0014869 \| reflux esophagitis \| 2 C0017178 \| gastrointestinal diseases \| 1 C0017178 \| gastrointestinal disorders \| 1 C0013299 \| duodenogastric reflux \| 1 C0008325 \| cholecystitis \| 1 C0740457 \| kidney cancer \| 1 C0017150 \| gastrinoma \| 1 C0038363 \| aphthous stomatitis \| 1 C0007570 \| celiac disease \| 1 C0206754 \| neuroendocrine tumor \| 1 C0162576 \| anisakiasis \| 1 C0030920 \| gastroduodenal ulcers \| 1 C0030920 \| peptic ulcer \| 1 C0021831 \| intestinal diseases \| 1 C0699791 \| gastric carcinoma \| 1 C0008350 \| gallstone \| 1 C0013990 \| emphysema \| 1 C0030809 \| pemphigus vulgaris \| 1 C0022658 \| renal disease \| 1 C0030807 \| pemphigus \| 1 C0031090 \| periodontal disease \| 1 C0022661 \| end-stage renal disease \| 1 C0398625 \| protein c deficiency \| 1 C0038362 \| stomatitis \| 1 C0235974 \| pancreatic cancer \| 1 C0017178 \| gastrointestinal disorder \| 1 C0032326 \| pneumothorax \| 1 C0085083 \| ovarian hyperstimulation syndrome \| 1 C0030920 \| peptic ulcer disease \| 1 C0017154 \| atrophic gastritis \| 1 C0004096 \| bronchial asthma \| 1 C0022354 \| obstructive jaundice \| 1 C1333321 \| duodenal gastrinoma \| 1 C1337035 \| xanthogranulomatous cholecystitis \| 1 C0030920 \| gastroduodenal ulcer \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:6) TGFB1 \| 7040 \| CTD_human NOS2 \| 4843 \| CTD_human PTGS2 \| 5743 \| CTD_human PLA2G4A \| 5321 \| CTD_human ABO \| 28 \| CTD_human;GWASCAT PSCA \| 8000 \| CTD_human;GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:9) 28 \| ABO \| infer 3119 \| HLA-DQB1 \| infer 3176 \| HNMT \| infer 3553 \| IL1B \| infer 3557 \| IL1RN \| infer 4353 \| MPO \| infer 4846 \| NOS3 \| infer 8000 \| PSCA \| infer 7124 \| TNF \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:124) 2519 \| FUCA2 \| DISEASES 6343 \| SCT \| DISEASES 27248 \| ERLEC1 \| DISEASES 28954 \| REM1 \| DISEASES 479 \| ATP12A \| DISEASES 2137 \| EXTL3 \| DISEASES 55824 \| PAG1 \| DISEASES 973 \| CD79A \| DISEASES 79176 \| FBXL15 \| DISEASES 5539 \| PPY \| DISEASES 5197 \| PF4V1 \| DISEASES 7841 \| MOGS \| DISEASES 3336 \| HSPE1 \| DISEASES 1958 \| EGR1 \| DISEASES 654231 \| OCM \| DISEASES 3306 \| HSPA2 \| DISEASES 7425 \| VGF \| DISEASES 3630 \| INS \| DISEASES 4922 \| NTS \| DISEASES 78986 \| DUSP26 \| DISEASES 2922 \| GRP \| DISEASES 2694 \| GIF \| DISEASES 4951 \| OCM2 \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 5858 \| PZP \| DISEASES 6521 \| SLC4A1 \| DISEASES 495 \| ATP4A \| DISEASES 25939 \| SAMHD1 \| DISEASES 8578 \| SCARF1 \| DISEASES 3553 \| IL1B \| DISEASES 23476 \| BRD4 \| DISEASES 5775 \| PTPN4 \| DISEASES 1615 \| DARS \| DISEASES 2247 \| FGF2 \| DISEASES 5443 \| POMC \| DISEASES 1950 \| EGF \| DISEASES 127 \| ADH4 \| DISEASES 51411 \| BIN2 \| DISEASES 1392 \| CRH \| DISEASES 3176 \| HNMT \| DISEASES 152273 \| FGD5 \| DISEASES 6750 \| SST \| DISEASES 7032 \| TFF2 \| DISEASES 114757 \| CYGB \| DISEASES 51127 \| TRIM17 \| DISEASES 886 \| CCKAR \| DISEASES 213 \| ALB \| DISEASES 201161 \| CENPV \| DISEASES 5479 \| PPIB \| DISEASES 6447 \| SCG5 \| DISEASES 8000 \| PSCA \| DISEASES 5617 \| PRL \| DISEASES 7200 \| TRH \| DISEASES 83886 \| PRSS27 \| DISEASES 2147 \| F2 \| DISEASES 29984 \| RHOD \| DISEASES 5340 \| PLG \| DISEASES 5222 \| PGA5 \| DISEASES 84260 \| TCHP \| DISEASES 65985 \| AACS \| DISEASES 7485 \| WRB \| DISEASES 2520 \| GAST \| DISEASES 796 \| CALCA \| DISEASES 8338 \| HIST2H2AC \| DISEASES 220323 \| OAF \| DISEASES 51738 \| GHRL \| DISEASES 887 \| CCKBR \| DISEASES 885 \| CCK \| DISEASES 3117 \| HLA-DQA1 \| DISEASES 8835 \| SOCS2 \| DISEASES 3167 \| HMX2 \| DISEASES 875 \| CBS \| DISEASES 5265 \| SERPINA1 \| DISEASES 2695 \| GIP \| DISEASES 26136 \| TES \| DISEASES 4149 \| MAX \| DISEASES 388677 \| NOTCH2NL \| DISEASES 5743 \| PTGS2 \| DISEASES 10223 \| GPA33 \| DISEASES 6279 \| S100A8 \| DISEASES 8337 \| HIST2H2AA3 \| DISEASES 537 \| ATP6AP1 \| DISEASES 2316 \| FLNA \| DISEASES 959 \| CD40LG \| DISEASES 1557 \| CYP2C19 \| DISEASES 5225 \| PGC \| DISEASES 3118 \| HLA-DQA2 \| DISEASES 5089 \| PBX2 \| DISEASES 2155 \| F7 \| DISEASES 3305 \| HSPA1L \| DISEASES 3055 \| HCK \| DISEASES 9576 \| SPAG6 \| DISEASES 23412 \| COMMD3 \| DISEASES 3274 \| HRH2 \| DISEASES 765 \| CA6 \| DISEASES 1906 \| EDN1 \| DISEASES 6649 \| SOD3 \| DISEASES 2962 \| GTF2F1 \| DISEASES 65010 \| SLC26A6 \| DISEASES 79924 \| ADM2 \| DISEASES 2919 \| CXCL1 \| DISEASES 2641 \| GCG \| DISEASES 4295 \| MLN \| DISEASES 131578 \| LRRC15 \| DISEASES 279 \| AMY2A \| DISEASES 7124 \| TNF \| DISEASES 9228 \| DLGAP2 \| DISEASES 4049 \| LTA \| DISEASES 4588 \| MUC6 \| DISEASES 3586 \| IL10 \| DISEASES 10772 \| SRSF10 \| DISEASES 131 \| ADH7 \| DISEASES 64641 \| EBF2 \| DISEASES 5333 \| PLCD1 \| DISEASES 9774 \| BCLAF1 \| DISEASES 4586 \| MUC5AC \| DISEASES 26298 \| EHF \| DISEASES 142891 \| SAMD8 \| DISEASES 246744 \| STH \| DISEASES 8972 \| MGAM \| DISEASES 27229 \| TUBGCP4 \| DISEASES 102723508 \| KANTR \| DISEASES 6080 \| SNORA73A \| DISEASES
Locus	(Waiting for update.)

Disease ID	191
Disease	duodenal ulcer
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:36) HP:0005202 \| Helicobacter pylori infection \| 8 HP:0002239 \| Gastrointestinal hemorrhage \| 6 HP:0005263 \| Gastritis \| 5 HP:0002584 \| Intestinal hemorrhage \| 5 HP:0001733 \| Pancreatic inflammation \| 4 HP:0012126 \| Gastric cancer \| 3 HP:0012531 \| Pain \| 3 HP:0002586 \| Peritonitis \| 3 HP:0002021 \| Pyloric stenosis \| 3 HP:0002592 \| Stomach ulcer \| 3 HP:0002027 \| Abdominal pain \| 2 HP:0002013 \| Emesis \| 2 HP:0100633 \| Inflammation of the esophagus \| 2 HP:0001735 \| Acute pancreatitis \| 2 HP:0002097 \| Pulmonary emphysema \| 1 HP:0001712 \| Left ventricular hypertrophy \| 1 HP:0030731 \| Carcinoma \| 1 HP:0001696 \| Situs inversus totalis \| 1 HP:0012587 \| Gross hematuria \| 1 HP:0000969 \| Dropsy \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0004398 \| Peptic ulcer \| 1 HP:0100592 \| Peritoneal abscess \| 1 HP:0001714 \| Ventricular hypertrophy \| 1 HP:0001082 \| Cholecystitis \| 1 HP:0003256 \| Coagulopathy \| 1 HP:0100790 \| Hernia \| 1 HP:0005543 \| Reduced protein C activity \| 1 HP:0002020 \| Heartburn \| 1 HP:0002894 \| Neoplasia of the pancreas \| 1 HP:0002615 \| Low blood pressure \| 1 HP:0002107 \| Collapsed lung \| 1 HP:0010280 \| Stomatitis \| 1 HP:0002608 \| Celiac disease \| 1 HP:0000952 \| Yellow skin \| 1 HP:0002099 \| Asthma \| 1

Disease ID	191
Disease	duodenal ulcer
Manually Symptom	UMLS \| Name(Total Manually Symptoms:90) C2712332 \| vomiting C2707258 \| infections C2697424 \| gastric cancer C2632116 \| stenosis C2598155 \| pain C2364133 \| infection C2364072 \| depression C2240374 \| eosinophilia C2220255 \| motor disturbances C2203646 \| jaundice C1963119 \| stomach ulcer C1963106 \| esophagitis C1963064 \| anxiety C1718184 \| pain symptoms C1609535 \| invasive candidiasis C1550639 \| fistula C1541124 \| pyloric obstruction C1522057 \| duodenitis C1330961 \| acidity C1313980 \| ischemic heart disease C1258215 \| ileus C1112575 \| antral g-cell hyperplasia C0858734 \| insulin hypoglycemia C0850666 \| helicobacter pylori infections C0850666 \| helicobacter pylori infection C0850666 \| h. pylori infection C0850666 \| h pylori infection C0796095 \| c syndrome C0744318 \| gastroesophageal reflux symptoms C0700361 \| distress C0699791 \| carcinoma of the stomach C0699791 \| cancer of the stomach C0699791 \| cancer of stomach C0677659 \| reflux oesophagitis C0677659 \| reflux esophagitis C0474585 \| melena C0343378 \| helicobacter pylori gastritis C0341365 \| colonic fistula C0341248 \| chronic duodenitis C0334533 \| arteriovenous malformation C0278701 \| adenocarcinoma of the stomach C0271710 \| reactive hypoglycemia C0267928 \| choledochoduodenal fistula C0267373 \| intestinal bleeding C0267158 \| reflux gastritis C0267146 \| chronic antral gastritis C0267055 \| erosive esophagitis C0264970 \| aneurysm of gastroduodenal artery C0262587 \| parathyroid adenoma C0235782 \| carcinoma of the gallbladder C0232493 \| epigastric pain C0232492 \| upper abdominal pain C0221757 \| alpha-1-antitrypsin deficiency C0162651 \| gastric outlet obstruction C0149696 \| food intolerance C0149670 \| disorders of carbohydrate metabolism C0149521 \| chronic pancreatitis C0038828 \| superior mesenteric artery syndrome C0030200 \| refractory pain C0028734 \| nycturia C0027809 \| schwannoma C0027709 \| nephrocalcinosis C0024623 \| gastric cancers C0024205 \| lymphadenitis C0023890 \| liver cirrhosis C0023890 \| cirrhosis of the liver C0022354 \| obstructive jaundice C0022104 \| irritable colon C0021053 \| immune system disorders C0020604 \| hypochondria C0020437 \| hypercalcemia C0019080 \| hemorrhage C0018926 \| hematemesis C0018801 \| cardiac failure C0017168 \| gastroesophageal reflux C0017168 \| gastro-oesophageal reflux disease C0017168 \| gastro-oesophageal reflux C0017168 \| gastro-esophageal reflux C0017152 \| gastritis C0017152 \| gastric inflammation C0014868 \| oesophagitis C0014848 \| cardiospasm C0013299 \| duodenogastric reflux C0013292 \| duodenal obstruction C0005416 \| biliary dyskinesia C0004936 \| mental disorders C0003615 \| appendicitis C0003490 \| aortic arch syndrome C0002962 \| angina pectoris C0002020 \| alexithymia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:21) C0009450 \| infection \| 20 C0850666 \| helicobacter pylori infection \| 8 C0850666 \| h. pylori infection \| 7 C0267373 \| intestinal bleeding \| 5 C0009814 \| stenosis \| 5 C0017152 \| gastritis \| 5 C0019080 \| hemorrhage \| 4 C0030193 \| pain \| 3 C0016169 \| fistula \| 3 C0024623 \| gastric cancer \| 3 C0014868 \| esophagitis \| 2 C0014869 \| reflux esophagitis \| 2 C0042963 \| vomiting \| 2 C0267928 \| choledochoduodenal fistula \| 1 C0847097 \| acidity \| 1 C0013299 \| duodenogastric reflux \| 1 C0022346 \| jaundice \| 1 C0232493 \| epigastric pain \| 1 C0267055 \| erosive esophagitis \| 1 C0850666 \| h pylori infection \| 1 C0022354 \| obstructive jaundice \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:13)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10434	19496079	7422	VEGFA	umls:C0013295	BeFree	The G1612A(rs10434) and C936T(rs3025039) polymorphisms in the 3' untranslated region (3'-UTR) of VEGF gene were genotyped in a total of 844 subjects including 385 GC, 143 ulcer including 98 gastric ulcer (GU), 45 duodenal ulcer (DU), and 316 nonulcer subjects.	0.082638474	2009	VEGFA	6	43785475	A	G
rs11558538	18086566	3176	HNMT	umls:C0013295	BeFree	C314T polymorphism in histamine N-methyltransferase gene and susceptibility to duodenal ulcer in Chinese population.	0.002638474	2008	HNMT	2	138002079	C	T
rs2294008	25721731	8000	PSCA	umls:C0013295	BeFree	Association of PSCA rs2294008 gene variants with poor prognosis and increased susceptibility to gastric cancer and decreased risk of duodenal ulcer disease.	0.243452799	2015	PSCA	8	142680513	C	T
rs2294008	22387998	8000	PSCA	umls:C0013295	GWASCAT	The C allele of rs2294008 at PSCA was associated with increased risk of duodenal ulcer (odds ratio (OR) = 1.84; P = 3.92 × 10(-33)) in a recessive model but was associated with decreased risk of gastric cancer (OR = 0.79; P = 6.79 × 10(-12)), as reported previously.	0.243452799	2012	PSCA	8	142680513	C	T
rs2294008	25582162	8000	PSCA	umls:C0013295	BeFree	The PSCA rs2294008 C>T polymorphism may be acting through induction of gastric mucosal atrophy, finally leading to development of gastric ulcer and gastric cancer in PSCA rs2294008 T allele carriers, but not duodenal ulcer.	0.243452799	2015	PSCA	8	142680513	C	T
rs2294008	22387998	8000	PSCA	umls:C0013295	BeFree	The C allele of rs2294008 at PSCA was associated with increased risk of duodenal ulcer (odds ratio (OR) = 1.84; P = 3.92 × 10(-33)) in a recessive model but was associated with decreased risk of gastric cancer (OR = 0.79; P = 6.79 × 10(-12)), as reported previously.	0.243452799	2012	PSCA	8	142680513	C	T
rs2294008	22387998	8000	PSCA	umls:C0013295	GAD	[The C allele of rs2294008 at PSCA was associated with increased risk of duodenal ulcer (odds ratio (OR) = 1.84; P = 3.92 A 10(-33)) in a recessive model but was associated with decreased risk of gastric cancer (OR = 0.79; P = 6.79 A 10(-12)), as reported previously.]	0.243452799	2012	PSCA	8	142680513	C	T
rs3025039	19496079	7422	VEGFA	umls:C0013295	BeFree	The G1612A(rs10434) and C936T(rs3025039) polymorphisms in the 3' untranslated region (3'-UTR) of VEGF gene were genotyped in a total of 844 subjects including 385 GC, 143 ulcer including 98 gastric ulcer (GU), 45 duodenal ulcer (DU), and 316 nonulcer subjects.	0.082638474	2009	VEGFA	6	43784799	C	T
rs4986790	18755634	7099	TLR4	umls:C0013295	BeFree	TLR4/D299G/T399I polymorphisms were more frequent in duodenal ulcer and showed a trend in gastric cancer, when compared with non-atrophic gastritis.	0.00554839	2008	TLR4	9	117713024	A	G
rs4986791	18755634	7099	TLR4	umls:C0013295	BeFree	TLR4/D299G/T399I polymorphisms were more frequent in duodenal ulcer and showed a trend in gastric cancer, when compared with non-atrophic gastritis.	0.00554839	2008	TLR4	9	117713324	C	T
rs505922	22387998	28	ABO	umls:C0013295	GAD	[rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 A 10(-10)).]	0.243452799	2012	NA	NA	NA	NA	NA
rs505922	22387998	28	ABO	umls:C0013295	GWASCAT	The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)).	0.243452799	2012	NA	NA	NA	NA	NA
rs505922	22387998	28	ABO	umls:C0013295	BeFree	rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)).	0.243452799	2012	NA	NA	NA	NA	NA

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:102)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	39221925	rs4970625	C	A	rs4970625	22387998	4.06E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
1	69446281	rs6588344	T	G	rs6588344	22387998	3.05E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
1	106057617	rs11184596	T	C	rs11184596	22387998	1.83E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
2	38306415	rs4646430	C	G	rs4646430	22387998	8.52E-06	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
2	38306935	rs4646429	C	T	rs4646429	22387998	8.25E-06	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
2	38307643	rs10175338	G	T	rs10175338	22387998	9.25E-06	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
2	54615040	rs13407315	T	C	rs13407315	22387998	3.44E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
2	145875289	rs1997287	C	T	rs1997287	22387998	4.29E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
3	167663718	rs6444751	A	G	rs6444751	22387998	4.44E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
3	167682686	rs9683345	T	C	rs9683345	22387998	6.47E-06	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
3	167690296	rs7619300	T	C	rs7619300	22387998	6.45E-06	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
3	167694177	rs12630921	G	T	rs12630921	22387998	1.26E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
3	167696174	rs4431164	C	A	rs4431164	22387998	8.90E-06	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
3	167699702	rs7631039	A	C	rs7631039	22387998	1.24E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
3	179606442	rs9290684	G	T	rs9290684	22387998	2.95E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
4	85637635	rs2015631	T	C	rs2015631	22387998	2.40E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
4	85664294	rs894533	C	T	rs894533	22387998	3.12E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
4	85734049	rs1484662	G	A	rs1484662	22387998	3.12E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
4	85782946	rs11726635	G	A	rs11726635	22387998	3.12E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
4	85844157	rs10516733	G	A	rs10516733	22387998	3.07E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
4	146434680	rs7662541	C	T	rs7662541	22387998	3.79E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
4	146453921	rs7670486	G	A	rs7670486	22387998	3.92E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
5	133268881	rs2869178	C	T	rs2869178	22387998	3.89E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
6	65824579	rs975618	G	A	rs975618	22387998	4.93E-07	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
6	65861193	rs7775478	G	T	rs7775478	22387998	4.31E-07	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
6	65871821	rs12198932	C	T	rs12198932	22387998	1.80E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
6	65886480	rs531101	C	T	rs531101	22387998	1.94E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
6	65905998	rs16896391	T	C	rs16896391	22387998	4.10E-07	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
6	65940233	rs2788907	G	A	rs2788907	22387998	8.36E-06	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
6	65952526	rs533110	G	T	rs533110	22387998	3.65E-06	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
6	65957304	rs6905713	C	T	rs6905713	22387998	3.66E-06	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
6	65969239	rs536372	T	C	rs536372	22387998	3.65E-06	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
6	65989292	rs13197839	A	C	rs13197839	22387998	2.22E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
6	66009103	rs9354219	G	T	rs9354219	22387998	2.71E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
6	66021416	rs6937429	T	G	rs6937429	22387998	1.80E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
6	66030650	rs7754286	T	G	rs7754286	22387998	1.52E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
6	66039601	rs9354228	G	A	rs9354228	22387998	1.61E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
7	27996570	rs17156085	C	T	rs17156085	22387998	1.03E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
7	54208630	rs10224185	T	C	rs10224185	22387998	4.43E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
7	127286897	rs2141259	A	G	rs2141259	22387998	3.59E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
7	127553025	rs3808084	A	G	rs3808084	22387998	2.55E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
7	127556713	rs1075206	T	C	rs1075206	22387998	1.84E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
8	17781257	rs12718385	T	C	rs12718385	22387998	4.08E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
8	70748924	rs3814489	T	C	rs3814489	22387998	3.41E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
8	81449141	rs1863593	T	C	rs1863593	22387998	1.49E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
8	88801153	rs2240458	C	T	rs2240458	22387998	9.22E-06	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
8	98664528	rs4448244	C	T	rs4448244	22387998	4.46E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
8	143656021	rs6996219	A	G	rs6996219	22387998	4.82E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
8	143660032	rs4073782	C	T	rs4073782	22387998	2.67E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
8	143660669	rs4073410	G	A	rs4073410	22387998	2.77E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
8	143664312	rs3934486	A	G	rs3934486	22387998	3.30E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
8	143671615	rs10105842	C	T	rs10105842	22387998	2.10E-08	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
8	143686995	rs9324593	A	G	rs9324593	22387998	3.23E-08	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
8	143694184	rs10097505	G	A	rs10097505	22387998	2.86E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
8	143707473	rs28473387	T	C	rs28473387	22387998	1.31E-10	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
8	143757037	rs2920283	T	C	rs2920283	22387998	2.45E-18	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
8	143761931	rs2294008	C	T	rs2294008	22387998	2.00E-33	Additive	1.41	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	rs2294008-C	Meta-Analysis	Research Support, Non-U.S. Gov't	T
8	143763083	rs2920297	A	G	rs2920297	22387998	4.12E-18	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
8	143763958	rs1045574	G	A	rs1045574	22387998	1.34E-18	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
8	143765885	rs12155758	G	A	rs12155758	22387998	1.11E-08	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
8	143784500	rs2244163	T	G	rs2244163	22387998	1.40E-08	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
8	143785659	rs2164308	C	T	rs2164308	22387998	5.56E-07	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
8	143792193	rs2572904	A	C	rs2572904	22387998	5.82E-07	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
8	143806896	rs2585140	A	G	rs2585140	22387998	5.40E-07	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
8	143842901	rs1036385	T	C	rs1036385	22387998	2.94E-08	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
8	143867905	rs2572925	C	T	rs2572925	22387998	6.32E-07	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
8	143887957	rs11777634	C	T	rs11777634	22387998	5.98E-06	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
8	143887957	rs199911610	C	CGCT	rs11777634	22387998	5.98E-06	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
9	20464928	rs6475431	A	G	rs6475431	22387998	4.69E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
9	82243701	rs12337384	T	C	rs12337384	22387998	3.53E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
9	136117964	rs7469576	G	A	rs7469576	22387998	3.33E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
9	136118513	rs9411367	C	T	rs9411367	22387998	1.44E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
9	136119527	rs9919007	C	T	rs9919007	22387998	3.18E-07	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
9	136120091	rs9411471	G	A	rs9411471	22387998	3.22E-07	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
9	136121303	rs7855466	C	T	rs7855466	22387998	1.80E-07	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
9	136121441	rs7046863	T	C	rs7046863	22387998	3.34E-07	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
9	136139265	rs657152	C	A	rs657152	22387998	6.05E-08	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
9	136149229	rs505922	T	C	rs505922	22387998	1.00E-10	Recessive	1.32	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	rs505922-T	Meta-Analysis	Research Support, Non-U.S. Gov't	T
10	15437159	rs10508485	G	A	rs10508485	22387998	2.94E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
10	123615028	rs7092052	A	G	rs7092052	22387998	1.59E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
10	123626578	rs4429006	A	G	rs4429006	22387998	1.59E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
10	123673339	rs10749435	T	C	rs10749435	22387998	1.50E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
11	56797089	rs602991	T	G	rs602991	22387998	3.49E-06	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
12	57320618	rs11172067	T	C	rs11172067	22387998	9.32E-06	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
12	57321212	rs7296999	C	T	rs7296999	22387998	1.45E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
12	57322853	rs11172068	G	A	rs11172068	22387998	1.46E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
12	93469749	rs11608500	C	T	rs11608500	22387998	4.24E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
12	130952454	rs10161112	G	T	rs10161112	22387998	4.05E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
13	76558153	rs9544105	T	C	rs9544105	22387998	4.05E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
13	111134780	rs3803229	G	A	rs3803229	22387998	2.75E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C
15	23066736	rs7168367	C	T	rs7168367	22387998	4.03E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	T
15	72084693	rs11634405	A	G	rs11634405	22387998	2.50E-06	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
16	68363181	rs1111571	G	A	rs1111571	22387998	3.60E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
16	68384010	rs4783554	A	G	rs4783554	22387998	3.77E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
17	15647723	rs2240593	C	T	rs2240593	22387998	1.25E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
18	4242200	rs641205	G	A	rs641205	22387998	4.13E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
18	23039616	rs888285	G	A	rs888285	22387998	1.05E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
18	23045937	rs4800217	G	A	rs4800217	22387998	4.25E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
18	39892281	rs17610383	G	A	rs17610383	22387998	1.72E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
20	13264554	rs17191004	G	A	rs17191004	22387998	2.19E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	G
21	41948547	rs8127599	A	G	rs8127599	22387998	4.34E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	A
22	48510196	rs16998380	T	C	rs16998380	22387998	3.80E-05	NA	NA	NA	1,043 Japanese ancestry cases; 21,694 Japanese ancestry controls	Japanese(22737)	ALL(22737)	ASN(22737)	ALL(22737)	Duodenal ulcer	HPOID:0002588	Duodenal ulcer	DOID:1724	duodenal ulcer	D004381	Duodenal Ulcer	EFOID:0004607	duodenal ulcer	Peptic ulcer	NA	Meta-Analysis	Research Support, Non-U.S. Gov't	C

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:12)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0013295	ampicillin	D000667	69-53-4	duodenal ulcer	MESH:D004381	therapeutic	10671773
C0013295	atropine	D001285	51-55-8	duodenal ulcer	MESH:D004381	therapeutic	11595415
C0013295	capsaicin	D002211	404-86-4	duodenal ulcer	MESH:D004381	therapeutic	10671773
C0013295	cimetidine	D002927	51481-61-9	duodenal ulcer	MESH:D004381	therapeutic	12503773
C0013295	cisapride	D020117	81098-60-4	duodenal ulcer	MESH:D004381	therapeutic	11578711
C0013295	cysteamine	D003543	60-23-1	duodenal ulcer	MESH:D004381	marker/mechanism	15778430
C0013295	indomethacin	D007213	53-86-1	duodenal ulcer	MESH:D004381	marker/mechanism	10671773
C0013295	lansoprazole	D064747	-	duodenal ulcer	MESH:D004381	therapeutic	10383532
C0013295	nizatidine	D016567	76963-41-2	duodenal ulcer	MESH:D004381	therapeutic	15235935
C0013295	omeprazole	D009853	73590-58-6	duodenal ulcer	MESH:D004381	therapeutic	1347322
C0013295	sucralfate	D013392	54182-58-0	duodenal ulcer	MESH:D004381	therapeutic	9881512
C0013295	tacrolimus	D016559	109581-93-3	duodenal ulcer	MESH:D004381	therapeutic	17202747

FDA approved drug and dosage information(Total Drugs:12)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D004381	prilosec	omeprazole	20MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	CAPSULE, DELAYED REL PELLETS;ORAL	Discontinued	None	Yes	No
MESH:D004381	prilosec	omeprazole	20MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	CAPSULE, DELAYED REL PELLETS;ORAL	Discontinued	None	Yes	No
MESH:D004381	omeprazole	omeprazole	20MG	TABLET, DELAYED RELEASE;ORAL	Over-the-counter	None	Yes	Yes
MESH:D004381	omeprazole	omeprazole	20MG	TABLET, DELAYED RELEASE;ORAL	Over-the-counter	None	Yes	Yes
MESH:D004381	axid	nizatidine	150MG	CAPSULE;ORAL	Discontinued	None	No	No
MESH:D004381	axid	nizatidine	15MG/ML Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	SOLUTION;ORAL	Discontinued	None	Yes	No
MESH:D004381	prevacid	lansoprazole	15MG	CAPSULE, DELAYED REL PELLETS;ORAL	Prescription	AB	Yes	No
MESH:D004381	prevacid	lansoprazole	15MG/PACKET	FOR SUSPENSION, DELAYED RELEASE;ORAL	Discontinued	None	No	No
MESH:D004381	prevacid	lansoprazole	15MG	TABLET, DELAYED RELEASE, ORALLY DISINTEGRATING;ORAL	Prescription	None	Yes	No
MESH:D004381	prevacid	lansoprazole	15MG	CAPSULE, DELAYED REL PELLETS;ORAL	Prescription	AB	Yes	No
MESH:D004381	prevacid	lansoprazole	15MG/PACKET	FOR SUSPENSION, DELAYED RELEASE;ORAL	Discontinued	None	No	No
MESH:D004381	prevacid	lansoprazole	15MG	TABLET, DELAYED RELEASE, ORALLY DISINTEGRATING;ORAL	Prescription	None	Yes	No

FDA labeling changes(Total Drugs:12)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D004381	12/7/2002	prilosec	omeprazole	Gastroesophageal reflux and erosive esophagitis	Safety and effectiveness established in pediatric patients 2-16 years of age Information on dose, PK parameters, exposure/response and AE profile	Labeling	B	-	-	-	AstraZeneca	-	FALSE'
MESH:D004381	03/20/2008	prilosec	omeprazole	Maintenance healing of erosive esophagitis	Efficacy was extrapolated from adults and older children to 1 to 2 year olds and supported with an open-label trial Unique adverse reactions in pediatric patients included increased respiratory system adverse events and fever. Safety and effectiveness in children less than 1 year of age have not been established Dosing and administration information provided for patients 1 year and older weighing at least 5 kg. New dosage form	Labeling	-	-	B, P	-	AstraZeneca	1/5/2001	FALSE'
MESH:D004381	12/7/2002	prilosec	omeprazole	Gastroesophageal reflux and erosive esophagitis	Safety and effectiveness established in pediatric patients 2-16 years of age Information on dose, PK parameters, exposure/response and AE profile	Labeling	B	-	-	-	AstraZeneca	-	FALSE'
MESH:D004381	03/20/2008	prilosec	omeprazole	Maintenance healing of erosive esophagitis	Efficacy was extrapolated from adults and older children to 1 to 2 year olds and supported with an open-label trial Unique adverse reactions in pediatric patients included increased respiratory system adverse events and fever. Safety and effectiveness in children less than 1 year of age have not been established Dosing and administration information provided for patients 1 year and older weighing at least 5 kg. New dosage form	Labeling	-	-	B, P	-	AstraZeneca	1/5/2001	FALSE'
MESH:D004381	05/25/2004	axid	nizatidine	Esophagitis, and heartburn due to GERD	Indicated in pediatric patients 12 years and older Information on dose, PK parameters, and AE profile	Labeling	B	-	-	-	Reliant Pharms	-	FALSE'
MESH:D004381	05/25/2004	axid	nizatidine	Esophagitis, and heartburn due to GERD	Indicated in pediatric patients 12 years and older Information on dose, PK parameters, and AE profile	Labeling	B	-	-	-	Reliant Pharms	-	FALSE'
MESH:D004381	06/17/2004	prevacid	lansoprazole	Short-term treatment of symptomatic GERD and erosive Esophagitis	Expanded age range to include patients 12 -17 years of age; previously labeled only in pediatric patients 1-11 years of age Safety and effectiveness in pediatric patients	Labeling	B	-	-	-	Tap	07/15/2008	FALSE'
MESH:D004381	06/17/2004	prevacid	lansoprazole	Short-term treatment of symptomatic GERD and erosive Esophagitis	Expanded age range to include patients 12 -17 years of age; previously labeled only in pediatric patients 1-11 years of age Safety and effectiveness in pediatric patients	Labeling	B	-	-	-	Tap	07/15/2008	FALSE'
MESH:D004381	06/17/2004	prevacid	lansoprazole	Short-term treatment of symptomatic GERD and erosive Esophagitis	Expanded age range to include patients 12 -17 years of age; previously labeled only in pediatric patients 1-11 years of age Safety and effectiveness in pediatric patients	Labeling	B	-	-	-	Tap	07/15/2008	FALSE'
MESH:D004381	10/28/2008	prevacid	lansoprazole	Symptomatic GERD in infants	Effectiveness was not established in a 4 week multicenter, double-blind, placebo-controlled study of patients 1 month and < 12 months of age AE profile similar to that observed in adultsInformation on PK parameters in neonates to < 1 year, and clinical studies	Labeling	-	-	B, P	-	Takeda	07/15/2008	FALSE'
MESH:D004381	10/28/2008	prevacid	lansoprazole	Symptomatic GERD in infants	Effectiveness was not established in a 4 week multicenter, double-blind, placebo-controlled study of patients 1 month and < 12 months of age AE profile similar to that observed in adultsInformation on PK parameters in neonates to < 1 year, and clinical studies	Labeling	-	-	B, P	-	Takeda	07/15/2008	FALSE'
MESH:D004381	10/28/2008	prevacid	lansoprazole	Symptomatic GERD in infants	Effectiveness was not established in a 4 week multicenter, double-blind, placebo-controlled study of patients 1 month and < 12 months of age AE profile similar to that observed in adultsInformation on PK parameters in neonates to < 1 year, and clinical studies	Labeling	-	-	B, P	-	Takeda	07/15/2008	FALSE'