PedAM
Pediatric Disease Annotations & Medicines
| drug dependence | ||||
| Disease ID | 1269 |
|---|---|
| Disease | drug dependence |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:16) HP:0000739 | Anxiety | 7 HP:0000708 | Behavioral problems | 4 HP:0007302 | Bipolar disorder | 2 HP:0000716 | Depression | 2 HP:0100543 | Cognitive deficits | 2 HP:0001513 | Obesity | 2 HP:0000217 | Dry mouth syndrome | 1 HP:0002076 | Migraine headaches | 1 HP:0100710 | Impulsivity | 1 HP:0012531 | Pain | 1 HP:0007018 | Attention deficits | 1 HP:0012532 | Chronic pain | 1 HP:0000752 | Hyperactive behavior | 1 HP:0100753 | Schizophrenia | 1 HP:0000726 | Dementia | 1 HP:0008760 | Violent behavior | 1 |
| Disease ID | 1269 |
|---|---|
| Disease | drug dependence |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:3) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:11) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs1229984 | 21497796 | 125 | ADH1B | umls:C1510472 | BeFree | A variant of the ADH1B gene (rs1229984 or Arg48His; previously referred to as Arg [*1] and His [*1]) has been reported to be associated with reduced rates of alcohol and drug dependence. | 0.002909916 | 2011 | ADH1B | 4 | 99318162 | T | C |
| rs1799971 | 22744787 | 4988 | OPRM1 | umls:C1510472 | BeFree | A significant association was observed between A118G polymorphism in μ opioid receptor gene and drug addiction. | 0.00434307 | 2012 | OPRM1 | 6 | 154039662 | A | G |
| rs1799971 | 20074870 | 4988 | OPRM1 | umls:C1510472 | BeFree | A common single nucleotide polymorphism (SNP), A118G, in the mu-opioid receptor gene can affect opioid function and, consequently, has been suggested to contribute to individual variability in pain management and drug addiction. | 0.00434307 | 2010 | OPRM1 | 6 | 154039662 | A | G |
| rs1799971 | 19528658 | 4988 | OPRM1 | umls:C1510472 | BeFree | A single nucleotide polymorphism (SNP) in the human mu-opioid receptor gene (OPRM1 A118G) has been widely studied for its association in a variety of drug addiction and pain sensitivity phenotypes; however, the extent of these adaptations and the mechanisms underlying these associations remain elusive. | 0.00434307 | 2009 | OPRM1 | 6 | 154039662 | A | G |
| rs1799971 | 23543091 | 4988 | OPRM1 | umls:C1510472 | BeFree | A single-nucleotide polymorphism (SNP) within the OPRM1 gene, A118G, leading to an amino acid change (Asn40Asp) in the extracellular portion of the receptor, has been implicated in alcoholism as well as in drug addiction, pain sensitivity and stress response, and in animal and human studies relates to the alcohol-dependent phenotype as well as to the treatment response to the µ-opioid antagonist naltrexone. | 0.00434307 | 2014 | OPRM1 | 6 | 154039662 | A | G |
| rs1799971 | 16046395 | 4988 | OPRM1 | umls:C1510472 | BeFree | Genetic variants of OPRM1 have been implicated in predisposition to drug addiction, in particular the single nucleotide polymorphism A118G, leading to an N40D substitution, with an allele frequency of 10-32%, and uncertain functions. | 0.00434307 | 2005 | OPRM1 | 6 | 154039662 | A | G |
| rs1800497 | 25500252 | 1813 | DRD2 | umls:C1510472 | BeFree | Growing evidence indicated conflicting results about the dopamine receptor D2 (DRD2)/kinase domain containing 1 gene (ANKK1) TaqIA single nucleotide polymorphism (rs1800497) and common illicit drug dependence risk including stimulants, opioid and marijuana. | 0.002442977 | 2014 | ANKK1 | 11 | 113400106 | G | A |
| rs279858 | 18482426 | 2555 | GABRA2 | umls:C1510472 | BeFree | These included a synonymous polymorphism in GABRA2 (rs279858), lying in a highly conserved region, which has been shown previously to be associated with alcohol and drug dependence. | 0.001085767 | 2008 | GABRA2 | 4 | 46312576 | T | C |
| rs324420 | 24407958 | 2166 | FAAH | umls:C1510472 | BeFree | As conclusion, because drug addiction is a multi-step process and a preventable disease, our results indicate that the FAAH C385A SNP is one of the most promising candidates for individuals who are at higher risk for alcohol problems. | 0.001085767 | 2013 | FAAH | 1 | 46405089 | C | A |
| rs324420 | 16972078 | 2166 | FAAH | umls:C1510472 | BeFree | The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction. | 0.001085767 | 2006 | FAAH | 1 | 46405089 | C | A |
| rs386602118 | 16649215 | 627 | BDNF | umls:C1510472 | BeFree | This variant and two previously reported BDNF SNPs (C270T and Val66Met) were genotyped in 295 patients with AD, 108 with AFDs, 96 with posttraumatic stress disorder (PTSD), 84 with schizophrenia, 327 with alcohol and/or drug dependence, and 250 normal control subjects. | 0.000542884 | 2006 | NA | NA | NA | NA | NA |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:42) | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CHR | POS | SNPID | REF | ALT | ORI_SNPID | PMID | P_VALUE | P_VALUE_TEXT | OR/BETA | CI95_TEXT | GWAS_INITIAL_SAMPLE_SIZE | SUB_POPULATION | SUPER_POPULATION | GWAS_TRAIT | HPO_ID | HPO_TERM | DO_ID | DO_TERM | MESH_ID | MESH_TERM | EFO_ID | EFO_TERM | DOLITE_TERM | RISK_ALLELE | PUBLICATION_TYPE | AA | GENE_SYMBOL | TYPE | REFGENE |
| 1 | 186967193 | rs1474797 | A | G | rs1474797 | 23183491 | 1.13E-04 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 1 | 204828041 | rs12043259 | C | G | rs12043259 | 23533358 | 2.00E-11 | NA | NA | NA | 1,393 European ancestry women; 1,131 European ancestry men; 568 African ancestry women; 535 African ancestry men | African(1103) | European(2524) | ALL(3627) | AFR(1103) | EUR(2524) | ALL(3627) | Addiction | HPOID:0002720 | IgA deficiency | DOID:9974 | drug dependence | NA | NA | EFOID:0003890 | drug dependence | Drug abuse | NA | Research Support, N.I.H., Extramural |
| 1 | 207424727 | rs7545125 | A | G | rs7545125 | 17099884 | 5.60E-04 | NA | NA | NA | 980 cases; 680 controls | NOPOP(1660) | ALL(1660) | NOPOP(1660) | ALL(1660) | Addiction | HPOID:0002720 | IgA deficiency | DOID:9974 | drug dependence | NA | NA | EFOID:0003890 | drug dependence | Drug abuse | NA | Research Support, N.I.H., Intramural | Comparative Study | G |
| 2 | 106457291 | rs2377339 | A | G | rs2377339 | 23533358 | 1.00E-11 | Opiates - African ancestry men - allelic test | 13.87 | [NA] unit increase | 1,393 European ancestry women; 1,131 European ancestry men; 568 African ancestry women; 535 African ancestry men | African(1103) | European(2524) | ALL(3627) | AFR(1103) | EUR(2524) | ALL(3627) | Addiction | HPOID:0002720 | IgA deficiency | DOID:9974 | drug dependence | NA | NA | EFOID:0003890 | drug dependence | Drug abuse | rs2377339-G | Research Support, N.I.H., Extramural |
| 2 | 106457291 | rs2377339 | A | G | rs2377339 | 23533358 | 2.00E-08 | codependence - African ancestry men - adjusted analysis | NA | NA | 1,393 European ancestry women; 1,131 European ancestry men; 568 African ancestry women; 535 African ancestry men | African(1103) | European(2524) | ALL(3627) | AFR(1103) | EUR(2524) | ALL(3627) | Addiction | HPOID:0002720 | IgA deficiency | DOID:9974 | drug dependence | NA | NA | EFOID:0003890 | drug dependence | Drug abuse | rs2377339-G | Research Support, N.I.H., Extramural |
| 2 | 208444028 | rs2254137 | C | A | rs2254137 | 23183491 | 1.12E-05 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 2 | 208494234 | rs2952768 | T | C | rs2952768 | 23183491 | 8.00E-07 | NA | 0.29 | [NA] unit increase | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | rs2952768-C | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 2 | 208497034 | rs2709386 | G | A | rs2709386 | 23183491 | 1.14E-06 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 2 | 208501730 | rs7591784 | A | G | rs7591784 | 23183491 | 1.06E-06 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 3 | 14773267 | rs12496846 | A | G | rs12496846 | 23183491 | 3.24E-05 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 4 | 41056716 | rs114070671 | A | G | rs114070671 | 24143882 | 1.00E-07 | AA | NA | NA | 1,383 European ancestry cases; 996 European ancestry controls; 683 African American cases; 2,635 African American controls | African American(3318) | European(2379) | ALL(5697) | AFR(3318) | EUR(2379) | ALL(5697) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Research Support, N.I.H., Extramural |
| 4 | 41056839 | rs115368721 | G | A | rs115368721 | 24143882 | 1.92E-08 | Stage 1+2 only, AA | NA | NA | 1,383 European ancestry cases; 996 European ancestry controls; 683 African American cases; 2,635 African American controls | African American(3318) | European(2379) | ALL(5697) | AFR(3318) | EUR(2379) | ALL(5697) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Research Support, N.I.H., Extramural |
| 4 | 122928256 | rs1465040 | T | C | rs1465040 | 23183491 | 1.27E-06 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 5 | 10977322 | rs10052295 | A | G | rs10052295 | 23183491 | 1.62E-04 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 5 | 81717176 | rs224938 | C | T | rs224938 | 23183491 | 9.60E-07 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 5 | 81736795 | rs2429239 | A | C | rs2429239 | 23183491 | 4.90E-07 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 5 | 81915301 | rs6877560 | A | G | rs6877560 | 23183491 | 1.18E-04 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 5 | 177505795 | rs12517913 | C | T | rs12517913 | 23183491 | 3.21E-04 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 6 | 63585140 | rs1577822 | T | G | rs1577822 | 23183491 | 1.65E-04 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 6 | 63993375 | rs2459572 | C | T | rs2459572 | 23183491 | 2.47E-04 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 6 | 78420432 | rs7761742 | T | C | rs7761742 | 23183491 | 1.66E-05 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 6 | 93467158 | rs12211463 | T | G | rs12211463 | 21622719 | 5.80E-04 | Pain relief in opioid therapy for cancer | NA | NA | 286 European ancestry cases; 142 European ancestry controls; 2 African ancestry cases; 1 African ancestry control; 5 cases; 2 controls | NOPOP(7) | African(3) | European(428) | ALL(438) | NOPOP(7) | AFR(3) | EUR(428) | ALL(438) | Pain relief with opioid treatment | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | NA | NA | NA | NA | Drug abuse |
| 6 | 113479335 | rs2473967 | G | T | rs2473967 | 21622719 | 8.10E-06 | Pain relief in opioid therapy for cancer | NA | NA | 286 European ancestry cases; 142 European ancestry controls; 2 African ancestry cases; 1 African ancestry control; 5 cases; 2 controls | NOPOP(7) | African(3) | European(428) | ALL(438) | NOPOP(7) | AFR(3) | EUR(428) | ALL(438) | Pain relief with opioid treatment | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | NA | NA | NA | NA | Drug abuse |
| 6 | 130495883 | rs10223341 | G | T | rs10223341 | 23183491 | 3.72E-05 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 7 | 7604076 | rs17168704 | C | G | rs17168704 | 17099884 | 6.40E-04 | NA | NA | NA | 980 cases; 680 controls | NOPOP(1660) | ALL(1660) | NOPOP(1660) | ALL(1660) | Addiction | HPOID:0002720 | IgA deficiency | DOID:9974 | drug dependence | NA | NA | EFOID:0003890 | drug dependence | Drug abuse | NA | Research Support, N.I.H., Intramural | Comparative Study | G |
| 7 | 29371948 | rs39131 | A | G | rs39131 | 17099884 | 5.80E-04 | NA | NA | NA | 980 cases; 680 controls | NOPOP(1660) | ALL(1660) | NOPOP(1660) | ALL(1660) | Addiction | HPOID:0002720 | IgA deficiency | DOID:9974 | drug dependence | NA | NA | EFOID:0003890 | drug dependence | Drug abuse | NA | Research Support, N.I.H., Intramural | Comparative Study | G |
| 8 | 3898329 | rs2912272 | T | G | rs2912272 | 17099884 | 2.50E-04 | NA | NA | NA | 980 cases; 680 controls | NOPOP(1660) | ALL(1660) | NOPOP(1660) | ALL(1660) | Addiction | HPOID:0002720 | IgA deficiency | DOID:9974 | drug dependence | NA | NA | EFOID:0003890 | drug dependence | Drug abuse | NA | Research Support, N.I.H., Intramural | Comparative Study | G |
| 8 | 40984060 | rs13266712 | C | A | rs13266712 | 23183491 | 4.27E-05 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 9 | 23785967 | rs2195731 | C | A | rs2195731 | 23183491 | 1.85E-05 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 10 | 52009648 | rs1898198 | A | G | rs1898198 | 23183491 | 1.28E-05 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 10 | 52013640 | rs11004819 | C | T | rs11004819 | 23183491 | 1.29E-05 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 11 | 12454744 | rs73411566 | T | C | rs73411566 | 24143882 | 1.75E-08 | Stage 1+2 only, AA | NA | NA | 1,383 European ancestry cases; 996 European ancestry controls; 683 African American cases; 2,635 African American controls | African American(3318) | European(2379) | ALL(5697) | AFR(3318) | EUR(2379) | ALL(5697) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Research Support, N.I.H., Extramural |
| 11 | 14079931 | rs7104613 | C | T | rs7104613 | 21622719 | 6.80E-05 | Pain relief in opioid therapy for cancer | NA | NA | 286 European ancestry cases; 142 European ancestry controls; 2 African ancestry cases; 1 African ancestry control; 5 cases; 2 controls | NOPOP(7) | African(3) | European(428) | ALL(438) | NOPOP(7) | AFR(3) | EUR(428) | ALL(438) | Pain relief with opioid treatment | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | NA | NA | NA | NA | Drug abuse |
| 11 | 17796111 | rs60349741 | A | C | rs60349741 | 24143882 | 5.00E-07 | AA | NA | NA | 1,383 European ancestry cases; 996 European ancestry controls; 683 African American cases; 2,635 African American controls | African American(3318) | European(2379) | ALL(5697) | AFR(3318) | EUR(2379) | ALL(5697) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Research Support, N.I.H., Extramural |
| 11 | 27311814 | rs7479309 | A | G | rs7479309 | 23183491 | 4.22E-06 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 11 | 27337345 | rs1478684 | T | G | rs1478684 | 23183491 | 5.37E-05 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 11 | 27337843 | rs2045935 | A | G | rs2045935 | 23183491 | 5.37E-05 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
| 13 | 38059218 | rs7324216 | C | T | rs7324216 | 17099884 | 6.50E-04 | NA | NA | NA | 980 cases; 680 controls | NOPOP(1660) | ALL(1660) | NOPOP(1660) | ALL(1660) | Addiction | HPOID:0002720 | IgA deficiency | DOID:9974 | drug dependence | NA | NA | EFOID:0003890 | drug dependence | Drug abuse | NA | Research Support, N.I.H., Intramural | Comparative Study | T |
| 13 | 38112413 | rs10467365 | A | C,T | rs10467365 | 17099884 | 6.50E-04 | NA | NA | NA | 980 cases; 680 controls | NOPOP(1660) | ALL(1660) | NOPOP(1660) | ALL(1660) | Addiction | HPOID:0002720 | IgA deficiency | DOID:9974 | drug dependence | NA | NA | EFOID:0003890 | drug dependence | Drug abuse | NA | Research Support, N.I.H., Intramural | Comparative Study | A |
| 17 | 74499400 | rs12948783 | G | A | rs12948783 | 21622719 | 8.10E-09 | Pain relief in opioid therapy for cancer | NA | NA | 286 European ancestry cases; 142 European ancestry controls; 2 African ancestry cases; 1 African ancestry control; 5 cases; 2 controls | NOPOP(7) | African(3) | European(428) | ALL(438) | NOPOP(7) | AFR(3) | EUR(428) | ALL(438) | Pain relief with opioid treatment | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | NA | NA | NA | NA | Drug abuse |
| 18 | 77624479 | rs62103177 | G | A | rs62103177 | 24143882 | 4.00E-10 | AA | NA | NA | 1,383 European ancestry cases; 996 European ancestry controls; 683 African American cases; 2,635 African American controls | African American(3318) | European(2379) | ALL(5697) | AFR(3318) | EUR(2379) | ALL(5697) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Research Support, N.I.H., Extramural |
| 19 | 47937466 | rs698705 | A | G | rs698705 | 23183491 | 3.67E-05 | NA | NA | NA | 118 Japanese ancestry individuals | Japanese(118) | ALL(118) | ASN(118) | ALL(118) | Opioid sensitivity | HPOID:0007354 | Amyotrophic lateral sclerosis | DOID:9974 | drug dependence | D009293 | Opioid-Related Disorders | NA | NA | Drug abuse | NA | Multicenter Study | Clinical Trial | Research Support, Non-U.S. Gov't |
Mapped by lexical matching(Total Items:0) |
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Mapped by homologous gene(Total Items:0) |
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Chemical(Total Drugs:0) | |
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FDA approved drug and dosage information(Total Drugs:0) | |
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FDA labeling changes(Total Drugs:0) | |
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