PedAM
Pediatric Disease Annotations & Medicines
| discitis | ||||
| Disease ID | 1839 |
|---|---|
| Disease | discitis |
| Definition | Inflammation of an INTERVERTEBRAL DISC or disk space which may lead to disk erosion. Until recently, discitis has been defined as a nonbacterial inflammation and has been attributed to aseptic processes (e.g., chemical reaction to an injected substance). However, recent studies provide evidence that infection may be the initial cause, but perhaps not the promoter, of most cases of discitis. Discitis has been diagnosed in patients following discography, myelography, lumbar puncture, paravertebral injection, and obstetrical epidural anesthesia. Discitis following chemonucleolysis (especially with chymopapain) is attributed to chemical reaction by some and to introduction of microorganisms by others. |
| Synonym | discitides discitis (disorder) discitis [disease/finding] discitis, nos diskitides diskitis intervertebral discitis spondylodiscitides spondylodiscitis spondylodiskitides spondylodiskitis |
| DOID | |
| UMLS | C0012624 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:8) |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:23) 84245 | MRI1 | DISEASES 1088 | CEACAM8 | DISEASES 10343 | PKDREJ | DISEASES 1401 | CRP | DISEASES 11043 | MID2 | DISEASES 1462 | VCAN | DISEASES 64374 | SIL1 | DISEASES 2495 | FTH1 | DISEASES 56246 | MRAP | DISEASES 133522 | PPARGC1B | DISEASES 2744 | GLS | DISEASES 153571 | C5orf38 | DISEASES 6609 | SMPD1 | DISEASES 538 | ATP7A | DISEASES 2157 | F8 | DISEASES 51060 | TXNDC12 | DISEASES 64344 | HIF3A | DISEASES 3440 | IFNA2 | DISEASES 51520 | LARS | DISEASES 6164 | RPL34 | DISEASES 176 | ACAN | DISEASES 3712 | IVD | DISEASES 102723508 | KANTR | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 1839 |
|---|---|
| Disease | discitis |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:6) HP:0002754 | Bone infection | 3 HP:0003418 | Back pain | 2 HP:0100806 | Sepsis | 1 HP:0012531 | Pain | 1 HP:0004953 | Abdominal aortic aneurysm | 1 HP:0002617 | Aneurysmal dilatation | 1 |
| Disease ID | 1839 |
|---|---|
| Disease | discitis |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:4) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0012624 | diclofenac | D004008 | 15307-86-5 | discitis | MESH:D015299 | therapeutic | 9654706 | ||
| C0012624 | ofloxacin | D015242 | 82419-36-1 | discitis | MESH:D015299 | therapeutic | 19718264 | ||
| C0012624 | rifampin | D012293 | 13292-46-1 | discitis | MESH:D015299 | therapeutic | 19718264 | ||
| C0012624 | vancomycin | D014640 | 1404-90-6 | discitis | MESH:D015299 | therapeutic | 19718264 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
|---|---|
| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |