PedAM

Pediatric Disease Annotations & Medicines


	diphtheria

Disease ID	561
Disease	diphtheria
Definition	A localized infection of mucous membranes or skin caused by toxigenic strains of CORYNEBACTERIUM DIPHTHERIAE. It is characterized by the presence of a pseudomembrane at the site of infection. DIPHTHERIA TOXIN, produced by C. diphtheriae, can cause myocarditis, polyneuritis, and other systemic toxic effects.
Synonym	[x]diphtheria, unspecified [x]diphtheria, unspecified (disorder) diphtheria (disorder) diphtheria [disease/finding] diphtheria nos diphtheria nos (disorder) diphtheria, nos diphtheria, unspecified diphtherias infection caused by corynebacterium diphtheriae infection caused by corynebacterium diphtheriae (disorder) infection due to corynebacterium diphtheriae infection due to corynebacterium diphtheriae (disorder)
Orphanet	ORPHANET:1679
DOID	DOID:11405
ICD10	ICD10CM:A36.9
UMLS	C0012546
MeSH	D004165
SNOMED-CT	SNOMEDCT_US_2016_09_01:276197005;SNOMEDCT_US_2016_09_01:397428000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:18) C0006017 \| pertussis \| 7 C0039614 \| tetanus \| 2 C0041296 \| tuberculosis \| 2 C0376545 \| hematologic malignancies \| 1 C0003175 \| anthrax \| 1 C0008354 \| cholera \| 1 C0014544 \| epilepsy \| 1 C0025202 \| melanoma \| 1 C0409974 \| lupus erythematosus \| 1 C0027059 \| myocarditis \| 1 C0031350 \| pharyngitis \| 1 C0018078 \| gonococcal urethritis \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0002395 \| alzheimer's disease \| 1 C0018801 \| cardiac failure \| 1 C0152025 \| polyneuropathy \| 1 C0041976 \| urethritis \| 1 C0278883 \| metastatic melanoma \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:276) 4074 \| M6PR \| DISEASES 928 \| CD9 \| DISEASES 10911 \| UTS2 \| DISEASES 933 \| CD22 \| DISEASES 23409 \| SIRT4 \| DISEASES 3560 \| IL2RB \| DISEASES 5173 \| PDYN \| DISEASES 10916 \| MAGED2 \| DISEASES 7783 \| ZP2 \| DISEASES 4150 \| MAZ \| DISEASES 1445 \| CSK \| DISEASES 8857 \| FCGBP \| DISEASES 2217 \| FCGRT \| DISEASES 973 \| CD79A \| DISEASES 5539 \| PPY \| DISEASES 3558 \| IL2 \| DISEASES 2251 \| FGF6 \| DISEASES 3458 \| IFNG \| DISEASES 5459 \| POU4F3 \| DISEASES 1839 \| HBEGF \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 22924 \| MAPRE3 \| DISEASES 6402 \| SELL \| DISEASES 4360 \| MRC1 \| DISEASES 4852 \| NPY \| DISEASES 56829 \| ZC3HAV1 \| DISEASES 55509 \| BATF3 \| DISEASES 27304 \| MOCS3 \| DISEASES 140685 \| ZBTB46 \| DISEASES 611 \| OPN1SW \| DISEASES 22933 \| SIRT2 \| DISEASES 3630 \| INS \| DISEASES 2780 \| GNAT2 \| DISEASES 64428 \| NARFL \| DISEASES 7837 \| PXDN \| DISEASES 3975 \| LHX1 \| DISEASES 1802 \| DPH2 \| DISEASES 1840 \| DTX1 \| DISEASES 9883 \| POM121 \| DISEASES 29969 \| MDFIC \| DISEASES 269 \| AMHR2 \| DISEASES 3569 \| IL6 \| DISEASES 10241 \| CALCOCO2 \| DISEASES 4069 \| LYZ \| DISEASES 3074 \| HEXB \| DISEASES 5687 \| PSMA6 \| DISEASES 10681 \| GNB5 \| DISEASES 54956 \| PARP16 \| DISEASES 22818 \| COPZ1 \| DISEASES 9172 \| MYOM2 \| DISEASES 6521 \| SLC4A1 \| DISEASES 64377 \| CHST8 \| DISEASES 25939 \| SAMHD1 \| DISEASES 6492 \| SIM1 \| DISEASES 1434 \| CSE1L \| DISEASES 7350 \| UCP1 \| DISEASES 1801 \| DPH1 \| DISEASES 3682 \| ITGAE \| DISEASES 55686 \| MREG \| DISEASES 3553 \| IL1B \| DISEASES 64761 \| PARP12 \| DISEASES 5443 \| POMC \| DISEASES 411 \| ARSB \| DISEASES 3371 \| TNC \| DISEASES 2028 \| ENPEP \| DISEASES 1950 \| EGF \| DISEASES 7458 \| EIF4H \| DISEASES 38 \| ACAT1 \| DISEASES 26297 \| SERGEF \| DISEASES 3700 \| ITIH4 \| DISEASES 939 \| CD27 \| DISEASES 8549 \| LGR5 \| DISEASES 112802 \| KRT71 \| DISEASES 3067 \| HDC \| DISEASES 8128 \| ST8SIA2 \| DISEASES 5045 \| FURIN \| DISEASES 3687 \| ITGAX \| DISEASES 7157 \| TP53 \| DISEASES 2064 \| ERBB2 \| DISEASES 963 \| CD53 \| DISEASES 23432 \| GPR161 \| DISEASES 7483 \| WNT9A \| DISEASES 805 \| CALM2 \| DISEASES 3001 \| GZMA \| DISEASES 1956 \| EGFR \| DISEASES 22917 \| ZP1 \| DISEASES 54842 \| MFSD6 \| DISEASES 1436 \| CSF1R \| DISEASES 3815 \| KIT \| DISEASES 7484 \| WNT9B \| DISEASES 181 \| AGRP \| DISEASES 808 \| CALM3 \| DISEASES 643 \| CXCR5 \| DISEASES 729230 \| CCR2 \| DISEASES 3060 \| HCRT \| DISEASES 7471 \| WNT1 \| DISEASES 2215 \| FCGR3B \| DISEASES 213 \| ALB \| DISEASES 1359 \| CPA3 \| DISEASES 151636 \| DTX3L \| DISEASES 27242 \| TNFRSF21 \| DISEASES 3562 \| IL3 \| DISEASES 1437 \| CSF2 \| DISEASES 6862 \| T \| DISEASES 819 \| CAMLG \| DISEASES 139324 \| HDX \| DISEASES 322 \| APBB1 \| DISEASES 54495 \| TMX3 \| DISEASES 26253 \| CLEC4E \| DISEASES 6240 \| RRM1 \| DISEASES 84168 \| ANTXR1 \| DISEASES 3960 \| LGALS4 \| DISEASES 598 \| BCL2L1 \| DISEASES 3308 \| HSPA4 \| DISEASES 5968 \| REG1B \| DISEASES 5481 \| PPID \| DISEASES 79412 \| KREMEN2 \| DISEASES 3596 \| IL13 \| DISEASES 5046 \| PCSK6 \| DISEASES 3913 \| LAMB2 \| DISEASES 1938 \| EEF2 \| DISEASES 55695 \| NSUN5 \| DISEASES 2829 \| XCR1 \| DISEASES 836 \| CASP3 \| DISEASES 2000 \| ELF4 \| DISEASES 8658 \| TNKS \| DISEASES 11007 \| CCDC85B \| DISEASES 11120 \| BTN2A1 \| DISEASES 1464 \| CSPG4 \| DISEASES 3952 \| LEP \| DISEASES 5198 \| PFAS \| DISEASES 8636 \| SSNA1 \| DISEASES 6440 \| SFTPC \| DISEASES 8225 \| GTPBP6 \| DISEASES 8411 \| EEA1 \| DISEASES 56676 \| ASCL3 \| DISEASES 84875 \| PARP10 \| DISEASES 57716 \| PRX \| DISEASES 2300 \| FOXL1 \| DISEASES 5034 \| P4HB \| DISEASES 1915 \| EEF1A1 \| DISEASES 23542 \| MAPK8IP2 \| DISEASES 942 \| CD86 \| DISEASES 340075 \| ARSI \| DISEASES 340146 \| SLC35D3 \| DISEASES 23760 \| PITPNB \| DISEASES 23451 \| SF3B1 \| DISEASES 51548 \| SIRT6 \| DISEASES 51477 \| ISYNA1 \| DISEASES 135138 \| PACRG \| DISEASES 2246 \| FGF1 \| DISEASES 5329 \| PLAUR \| DISEASES 3329 \| HSPD1 \| DISEASES 6614 \| SIGLEC1 \| DISEASES 3010 \| HIST1H1T \| DISEASES 2029 \| ENSA \| DISEASES 25870 \| SUMF2 \| DISEASES 2066 \| ERBB4 \| DISEASES 921 \| CD5 \| DISEASES 2770 \| GNAI1 \| DISEASES 3605 \| IL17A \| DISEASES 10202 \| DHRS2 \| DISEASES 1465 \| CSRP1 \| DISEASES 23587 \| ELP5 \| DISEASES 204 \| AK2 \| DISEASES 6204 \| RPS10 \| DISEASES 4625 \| MYH7 \| DISEASES 4010 \| LMX1B \| DISEASES 419 \| ART3 \| DISEASES 801 \| CALM1 \| DISEASES 141 \| ADPRH \| DISEASES 60 \| ACTB \| DISEASES 26136 \| TES \| DISEASES 6714 \| SRC \| DISEASES 1524 \| CX3CR1 \| DISEASES 404552 \| SCGB1D4 \| DISEASES 55814 \| BDP1 \| DISEASES 56980 \| PRDM10 \| DISEASES 9179 \| AP4M1 \| DISEASES 4151 \| MB \| DISEASES 7037 \| TFRC \| DISEASES 170482 \| CLEC4C \| DISEASES 83666 \| PARP9 \| DISEASES 23560 \| GTPBP4 \| DISEASES 9760 \| TOX \| DISEASES 23038 \| WDTC1 \| DISEASES 1270 \| CNTF \| DISEASES 57829 \| ZP4 \| DISEASES 142 \| PARP1 \| DISEASES 25802 \| LMOD1 \| DISEASES 5788 \| PTPRC \| DISEASES 7827 \| NPHS2 \| DISEASES 1805 \| DPT \| DISEASES 55811 \| ADCY10 \| DISEASES 2214 \| FCGR3A \| DISEASES 388695 \| LYSMD1 \| DISEASES 8349 \| HIST2H2BE \| DISEASES 1268 \| CNR1 \| DISEASES 4803 \| NGF \| DISEASES 1847 \| DUSP5 \| DISEASES 2773 \| GNAI3 \| DISEASES 51611 \| DPH5 \| DISEASES 959 \| CD40LG \| DISEASES 80351 \| TNKS2 \| DISEASES 2060 \| EPS15 \| DISEASES 958 \| CD40 \| DISEASES 5328 \| PLAU \| DISEASES 54936 \| ADPRHL2 \| DISEASES 55315 \| SLC29A3 \| DISEASES 553115 \| PEF1 \| DISEASES 3561 \| IL2RG \| DISEASES 5081 \| PAX7 \| DISEASES 1460 \| CSNK2B \| DISEASES 10673 \| TNFSF13B \| DISEASES 7918 \| GPANK1 \| DISEASES 7916 \| PRRC2A \| DISEASES 50943 \| FOXP3 \| DISEASES 1041 \| CDSN \| DISEASES 10218 \| ANGPTL7 \| DISEASES 8869 \| ST3GAL5 \| DISEASES 6461 \| SHB \| DISEASES 8559 \| PRPF18 \| DISEASES 29103 \| DNAJC15 \| DISEASES 51334 \| PRR16 \| DISEASES 3559 \| IL2RA \| DISEASES 29126 \| CD274 \| DISEASES 10232 \| MSLN \| DISEASES 6545 \| SLC7A4 \| DISEASES 79866 \| BORA \| DISEASES 5077 \| PAX3 \| DISEASES 7784 \| ZP3 \| DISEASES 4901 \| NRL \| DISEASES 10039 \| PARP3 \| DISEASES 2642 \| GCGR \| DISEASES 3033 \| HADH \| DISEASES 7018 \| TF \| DISEASES 50489 \| CD207 \| DISEASES 2641 \| GCG \| DISEASES 8705 \| B3GALT4 \| DISEASES 3481 \| IGF2 \| DISEASES 1438 \| CSF2RA \| DISEASES 1719 \| DHFR \| DISEASES 7124 \| TNF \| DISEASES 6464 \| SHC1 \| DISEASES 83463 \| MXD3 \| DISEASES 6892 \| TAPBP \| DISEASES 162466 \| PHOSPHO1 \| DISEASES 30836 \| DNTTIP2 \| DISEASES 3586 \| IL10 \| DISEASES 81605 \| URM1 \| DISEASES 2257 \| FGF12 \| DISEASES 55250 \| ELP2 \| DISEASES 23218 \| NBEAL2 \| DISEASES 165631 \| PARP15 \| DISEASES 120526 \| DNAJC24 \| DISEASES 54625 \| PARP14 \| DISEASES 285381 \| DPH3 \| DISEASES 10189 \| ALYREF \| DISEASES 51428 \| DDX41 \| DISEASES 917 \| CD3G \| DISEASES 9793 \| CKAP5 \| DISEASES 4975 \| OMP \| DISEASES 930 \| CD19 \| DISEASES 83742 \| MARVELD1 \| DISEASES 3684 \| ITGAM \| DISEASES 8725 \| URI1 \| DISEASES 3949 \| LDLR \| DISEASES 2297 \| FOXD1 \| DISEASES 7138 \| TNNT1 \| DISEASES 2323 \| FLT3LG \| DISEASES 100287226 \| ZNF729 \| DISEASES 497634 \| LINC00293 \| DISEASES 677768 \| SCARNA13 \| DISEASES 26793 \| SNORD56 \| DISEASES 692199 \| SNORD84 \| DISEASES
Locus	(Waiting for update.)

Disease ID	561
Disease	diphtheria
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:9) HP:0001635 \| Congestive heart failure \| 1 HP:0003470 \| Inability to move \| 1 HP:0002861 \| Melanoma \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0012735 \| Coughing \| 1 HP:0001271 \| Polyneuropathy \| 1 HP:0012819 \| Myocarditis \| 1 HP:0002529 \| Neuronal loss in central nervous system \| 1 HP:0001945 \| Fever \| 1

Disease ID	561
Disease	diphtheria
Manually Symptom	UMLS \| Name(Total Manually Symptoms:30) C2598155 \| pain C2215935 \| complete heart block C1963234 \| serum sickness C1963101 \| encephalopathy C1962971 \| myocarditis C1839611 \| n syndrome C1611280 \| allergy C1393529 \| vascular complications C1318484 \| chimera C0878544 \| myocardial disease C0752303 \| urological manifestations C0747422 \| penicillin sensitivity C0740852 \| upper airway obstruction C0549124 \| arterial embolism C0427543 \| monocytosis C0264306 \| laryngeal obstruction C0262471 \| ent problem C0037285 \| skin manifestations C0032285 \| pneumonia C0031157 \| peritonsillar abscess C0027813 \| neuritis C0022116 \| ischemia C0019087 \| hemorrhagic disorders C0019087 \| haemorrhagic diathesis C0018991 \| hemiplegia C0017979 \| glycosuria C0014742 \| erythema multiforme C0014038 \| encephalitis C0007222 \| cardiovascular disorders C0001396 \| morgagni-adams-stokes syndrome
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0027059 \| myocarditis \| 1 C0008109 \| chimera \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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