PedAM

Pediatric Disease Annotations & Medicines


	diastolic heart failure

Disease ID	1268
Disease	diastolic heart failure
Definition	Heart failure caused by abnormal myocardial relaxation during DIASTOLE leading to defective cardiac filling.
Synonym	diastolc hrt failure nos diastolic failure heart diastolic heart failure (disorder) diastolic heart failure, unspecified diastolic heart failures heart failure diastolic heart failure, diastolic heart failure, diastolic [disease/finding] heart failures, diastolic
DOID	DOID:9775
UMLS	C1135196
MeSH	D054144
SNOMED-CT	SNOMEDCT_US_2016_09_01:418304008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:18) C0020538 \| hypertension \| 6 C0018801 \| heart failure \| 4 C0878544 \| cardiomyopathy \| 2 C0020542 \| pulmonary hypertension \| 2 C0948265 \| metabolic syndrome \| 1 C0031046 \| pericarditis \| 1 C0020538 \| systemic hypertension \| 1 C0011847 \| diabetes \| 1 C0003864 \| arthritis \| 1 C0020676 \| hypothyroidism \| 1 C0002726 \| amyloidosis \| 1 C0034063 \| pulmonary oedema \| 1 C1135191 \| systolic heart failure \| 1 C1565489 \| renal insufficiency \| 1 C0268407 \| cardiac amyloidosis \| 1 C0003873 \| rheumatoid arthritis \| 1 C0031048 \| constrictive pericarditis \| 1 C0011849 \| diabetes mellitus \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 1636 \| ACE \| infer 183 \| AGT \| infer 185 \| AGTR1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:77) 10454 \| TAB1 \| DISEASES 5816 \| PVALB \| DISEASES 10278 \| EFS \| DISEASES 191 \| AHCY \| DISEASES 7076 \| TIMP1 \| DISEASES 4313 \| MMP2 \| DISEASES 4350 \| MPG \| DISEASES 10105 \| PPIF \| DISEASES 6347 \| CCL2 \| DISEASES 4317 \| MMP8 \| DISEASES 7276 \| TTR \| DISEASES 7291 \| TWIST1 \| DISEASES 417 \| ART1 \| DISEASES 3958 \| LGALS3 \| DISEASES 1401 \| CRP \| DISEASES 10955 \| SERINC3 \| DISEASES 3569 \| IL6 \| DISEASES 4316 \| MMP7 \| DISEASES 1535 \| CYBA \| DISEASES 84695 \| LOXL3 \| DISEASES 7168 \| TPM1 \| DISEASES 5972 \| REN \| DISEASES 10217 \| CTDSPL \| DISEASES 185 \| AGTR1 \| DISEASES 4319 \| MMP10 \| DISEASES 1489 \| CTF1 \| DISEASES 9320 \| TRIP12 \| DISEASES 7079 \| TIMP4 \| DISEASES 1636 \| ACE \| DISEASES 90525 \| SHF \| DISEASES 4846 \| NOS3 \| DISEASES 116285 \| ACSM1 \| DISEASES 4323 \| MMP14 \| DISEASES 8567 \| MADD \| DISEASES 7423 \| VEGFB \| DISEASES 79901 \| CYBRD1 \| DISEASES 4312 \| MMP1 \| DISEASES 2274 \| FHL2 \| DISEASES 6546 \| SLC8A1 \| DISEASES 27152 \| INTU \| DISEASES 857 \| CAV1 \| DISEASES 7060 \| THBS4 \| DISEASES 4137 \| MAPT \| DISEASES 4306 \| NR3C2 \| DISEASES 7137 \| TNNI3 \| DISEASES 10166 \| SLC25A15 \| DISEASES 5348 \| FXYD1 \| DISEASES 7273 \| TTN \| DISEASES 8654 \| PDE5A \| DISEASES 4606 \| MYBPC2 \| DISEASES 4311 \| MME \| DISEASES 9181 \| ARHGEF2 \| DISEASES 183 \| AGT \| DISEASES 1490 \| CTGF \| DISEASES 2902 \| GRIN1 \| DISEASES 27063 \| ANKRD1 \| DISEASES 4318 \| MMP9 \| DISEASES 8518 \| IKBKAP \| DISEASES 1889 \| ECE1 \| DISEASES 23564 \| DDAH2 \| DISEASES 3055 \| HCK \| DISEASES 4879 \| NPPB \| DISEASES 4878 \| NPPA \| DISEASES 1471 \| CST3 \| DISEASES 5293 \| PIK3CD \| DISEASES 1536 \| CYBB \| DISEASES 1906 \| EDN1 \| DISEASES 7222 \| TRPC3 \| DISEASES 4891 \| SLC11A2 \| DISEASES 115677 \| NOSTRIN \| DISEASES 3491 \| CYR61 \| DISEASES 5817 \| PVR \| DISEASES 64283 \| ARHGEF28 \| DISEASES 347273 \| MURC \| DISEASES 100506742 \| CASP12 \| DISEASES 488 \| ATP2A2 \| DISEASES 4607 \| MYBPC3 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1268
Disease	diastolic heart failure
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:21) HP:0000822 \| Hypertension \| 7 HP:0001635 \| Congestive heart failure \| 4 HP:0002092 \| Pulmonary artery hypertension \| 2 HP:0001638 \| Cardiomyopathy \| 2 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0002119 \| Ventricular dilatation \| 1 HP:0100598 \| Pulmonary oedema \| 1 HP:0000821 \| Underactive thyroid \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0011034 \| Amyloid disease \| 1 HP:0001701 \| Pericarditis \| 1 HP:0030843 \| Cardiac amyloidosis \| 1 HP:0001709 \| Complete heart block \| 1 HP:0000969 \| Dropsy \| 1 HP:0012664 \| Reduced ejection fraction \| 1 HP:0002094 \| Dyspnea \| 1 HP:0002563 \| Constrictive pericarditis \| 1 HP:0012722 \| Heart block \| 1 HP:0005110 \| Atrial fibrillation \| 1 HP:0001369 \| Arthritis \| 1

Disease ID	1268
Disease	diastolic heart failure
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0427008 \| stiffness \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C1135196	cyclophosphamide	D003520	50-18-0	heart failure, diastolic	MESH:D054144	marker/mechanism	12227700

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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