PedAM

Pediatric Disease Annotations & Medicines


	dermatitis, atopic

Disease ID	880
Disease	dermatitis, atopic
Synonym	ad - atopic dermatitis allergic (intrinsic) eczema (disorder) allergic dermatitis allergic eczema atod atopic dermatitides atopic dermatitis atopic dermatitis (disorder) atopic dermatitis nos atopic dermatitis nos (disorder) atopic dermatitis, chronic atopic dermatitis, nos atopic eczema atopic neurodermatitides atopic neurodermatitis atopic neurodermatitis (disorder) besnier's prurigo canine atopy dermatitides, atopic dermatitis allergic dermatitis atopic dermatitis, atopic [disease/finding] disseminated neurodermatitides disseminated neurodermatitis eczema atopic eczema, allergic eczema, atopic neurodermatitides, atopic neurodermatitides, disseminated neurodermatitis, atopic neurodermatitis, disseminated
OMIM	OMIM:603165
DOID	DOID:3310
ICD10	ICD10CM:L20.81;ICD10CM:L20.0
MeSH	D003876
SNOMED-CT	SNOMEDCT_US_2016_09_01:24079001;SNOMEDCT_US_2016_09_01:200775004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:89) C0016470 \| food allergy \| 22 C0004096 \| asthma \| 18 C0013595 \| eczema \| 17 C0011603 \| dermatitis \| 14 C0035455 \| rhinitis \| 7 C0936250 \| eczema herpeticum \| 7 C2607914 \| allergic rhinitis \| 6 C0016470 \| food allergies \| 5 C0042109 \| urticaria \| 5 C0033860 \| psoriasis \| 5 C0022573 \| keratoconjunctivitis \| 4 C0028754 \| obesity \| 4 C0079840 \| milk allergy \| 4 C0011616 \| contact dermatitis \| 4 C0037317 \| sleep disturbance \| 3 C0002171 \| alopecia areata \| 2 C0007114 \| skin cancer \| 2 C0004096 \| bronchial asthma \| 2 C0268397 \| cutaneous amyloidosis \| 2 C0037274 \| skin disease \| 2 C0035305 \| retinal detachment \| 2 C0022398 \| hyper-ige syndrome \| 2 C0086543 \| cataracts \| 2 C0002170 \| alopecia \| 2 C0011615 \| atopic dermatitis \| 2 C0409974 \| lupus erythematosus \| 2 C0002726 \| amyloidosis \| 2 C0042900 \| vitiligo \| 2 C0024299 \| lymphoma \| 2 C0162820 \| allergic contact dermatitis \| 2 C0024299 \| malignant lymphoma \| 1 C1398341 \| sinus infection \| 1 C0042769 \| virus infection \| 1 C0017612 \| open-angle glaucoma \| 1 C0037354 \| smallpox \| 1 C0022593 \| keratosis \| 1 C0878675 \| erdheim-chester disease \| 1 C0037274 \| dermatoses \| 1 C0206180 \| anaplastic large cell lymphoma \| 1 C0022353 \| neonatal jaundice \| 1 C0027726 \| nephrotic syndrome \| 1 C0025064 \| mediastinitis \| 1 C0037274 \| skin diseases \| 1 C0035854 \| rosacea \| 1 C0019621 \| langerhans cell histiocytosis \| 1 C0025202 \| melanoma \| 1 C0011847 \| diabetes \| 1 C0040558 \| toxoplasmosis \| 1 C0011616 \| contact sensitivity \| 1 C0026975 \| myelitis \| 1 C0019618 \| histiocytosis \| 1 C0021053 \| immune disease \| 1 C0152257 \| mature cataract \| 1 C0011991 \| diarrhea \| 1 C0036920 \| sezary syndrome \| 1 C0017160 \| gastroenteritis \| 1 C0041296 \| tuberculosis \| 1 C0242350 \| erectile dysfunction \| 1 C0032914 \| preeclampsia \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0018818 \| ventricular septal defect \| 1 C0002173 \| follicular mucinosis \| 1 C0152230 \| cholinergic urticaria \| 1 C0026691 \| kawasaki disease \| 1 C0037274 \| skin disorder \| 1 C0007570 \| celiac disease \| 1 C0024530 \| malaria \| 1 C0011615 \| atopic eczema \| 1 C0009806 \| constipation \| 1 C0026393 \| molluscum contagiosum \| 1 C0272238 \| transient hypogammaglobulinemia of infancy \| 1 C0042384 \| vasculitis \| 1 C0017601 \| glaucoma \| 1 C0022578 \| keratoconus \| 1 C0016470 \| food hypersensitivity \| 1 C0577620 \| nut allergy \| 1 C0014544 \| epilepsy \| 1 C1527336 \| sjogren's syndrome \| 1 C0014868 \| esophagitis \| 1 C0162855 \| mucinosis \| 1 C0024302 \| large cell lymphoma \| 1 C0018621 \| pollen allergy \| 1 C0011570 \| depression \| 1 C0019360 \| zoster \| 1 C0020757 \| ichthyosis \| 1 C0003467 \| anxiety \| 1 C0155877 \| allergic asthma \| 1 C0037274 \| skin disorders \| 1 C0037274 \| dermatosis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:49) IL6 \| 3569 \| CTD_human CCL24 \| 6369 \| CTD_human CCL22 \| 6367 \| CTD_human IL13 \| 3596 \| CTD_human;GWASCAT IFNG \| 3458 \| CTD_human PPARA \| 5465 \| CTD_human C6orf10 \| 10665 \| GWASCAT IL1B \| 3553 \| CTD_human HLA-B \| 3106 \| GWASCAT CCR5 \| 1234 \| CTD_human SELE \| 6401 \| CTD_human CXCL10 \| 3627 \| CTD_human CARD11 \| 84433 \| CTD_human IL10 \| 3586 \| CTD_human SLC11A1 \| 6556 \| CTD_human OVOL1 \| 5017 \| CTD_human CCL5 \| 6352 \| CTD_human IL4 \| 3565 \| CTD_human IL5 \| 3567 \| CTD_human ZNF365 \| 22891 \| CTD_human;GWASCAT MIR6891 \| 102465537 \| GWASCAT CCR3 \| 1232 \| CTD_human VNN2 \| 8875 \| CTD_human CCL17 \| 6361 \| CTD_human CCL11 \| 6356 \| CTD_human GLB1 \| 2720 \| CTD_human;GWASCAT TSLP \| 85480 \| CTD_human RNF111 \| 54778 \| GWASCAT TNXB \| 7148 \| GWASCAT KIF3A \| 11127 \| GWASCAT CXCR3 \| 2833 \| CTD_human VNN1 \| 8876 \| CTD_human FLG \| 2312 \| CTD_human IFNL3 \| 282617 \| CTD_human PBX2 \| 5089 \| GWASCAT MAPK8 \| 5599 \| CTD_human STAT6 \| 6778 \| CTD_human ACTL9 \| 284382 \| CTD_human GPSM3 \| 63940 \| GWASCAT RTEL1-TNFRSF6B \| 100533107 \| GWASCAT IL33 \| 90865 \| CTD_human IL31 \| 386653 \| CTD_human CCDC80 \| 151887 \| CTD_human IL18R1 \| 8809 \| GWASCAT S100A8 \| 6279 \| CTD_human XIRP2-AS1 \| 100874011 \| GWASCAT LINC00824 \| 101927774 \| GWASCAT FLG-AS1 \| 339400 \| GWASCAT XIRP2 \| 129446 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:40) 1233 \| CCR4 \| infer 1215 \| CMA1 \| infer 1493 \| CTLA4 \| infer 2312 \| FLG \| infer 3592 \| IL12A \| infer 3593 \| IL12B \| infer 3594 \| IL12RB1 \| infer 3595 \| IL12RB2 \| infer 3596 \| IL13 \| infer 3606 \| IL18 \| infer 3565 \| IL4 \| infer 3566 \| IL4R \| infer 3660 \| IRF2 \| infer 2206 \| MS4A2 \| infer 10392 \| NOD1 \| infer 51131 \| PHF11 \| infer 11005 \| SPINK5 \| infer 7040 \| TGFB1 \| infer 7097 \| TLR2 \| infer 81794 \| ADAMTS10 \| infer 627 \| BDNF \| infer 718 \| C3 \| infer 6356 \| CCL11 \| infer 2056 \| EPO \| infer 2625 \| GATA3 \| infer 3105 \| HLA-A \| infer 3106 \| HLA-B \| infer 11127 \| KIF3A \| infer 4155 \| MBP \| infer 4689 \| NCF4 \| infer 4803 \| NGF \| infer 5017 \| OVOL1 \| infer 5696 \| PSMB8 \| infer 5698 \| PSMB9 \| infer 6036 \| RNASE2 \| infer 6037 \| RNASE3 \| infer 340443 \| RPS5P5 \| infer 6890 \| TAP1 \| infer 6891 \| TAP2 \| infer 6915 \| TBXA2R \| infer
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	880
Disease	dermatitis, atopic
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:69) HP:0012393 \| Allergy \| 43 HP:0000989 \| pruritis \| 38 HP:0002099 \| Asthma \| 17 HP:0000964 \| Eczema \| 13 HP:0012384 \| Nasal inflammation \| 6 HP:0003765 \| Psoriasis \| 5 HP:0003193 \| Allergic rhinitis \| 5 HP:0001025 \| Hives \| 5 HP:0000958 \| Xerosis \| 5 HP:0100327 \| Cow milk allergy \| 4 HP:0001096 \| Keratoconjunctivitis \| 4 HP:0001513 \| Obesity \| 4 HP:0003212 \| Elevated serum IgE \| 3 HP:0100725 \| Lichenification \| 3 HP:0002960 \| Autoimmune condition \| 3 HP:0002360 \| Sleep disturbance \| 3 HP:0001880 \| Eosinophilia \| 3 HP:0012309 \| Cutaneous amyloidosis \| 2 HP:0001596 \| Hair loss \| 2 HP:0001047 \| Atopic dermatitis \| 2 HP:0001019 \| Exfoliative dermititis \| 2 HP:0030828 \| Wheezing \| 2 HP:0001581 \| Recurrent skin infections \| 2 HP:0004313 \| Decreased immunoglobulin level \| 2 HP:0000541 \| Detached retina \| 2 HP:0002719 \| infections, recurrent \| 2 HP:0002665 \| Lymphoma \| 2 HP:0002229 \| Alopecia areata \| 2 HP:0011034 \| Amyloid disease \| 2 HP:0000518 \| Cataract \| 2 HP:0001629 \| Ventricular septal defects \| 1 HP:0000802 \| Erectile dysfunction \| 1 HP:0000501 \| Glaucoma \| 1 HP:0001061 \| Acne \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0002015 \| Swallowing difficulty \| 1 HP:0000952 \| Yellow skin \| 1 HP:0000969 \| Dropsy \| 1 HP:0000563 \| Conical cornea \| 1 HP:0002019 \| Dyschezia \| 1 HP:0100602 \| Pre-eclampsia \| 1 HP:0000966 \| Decreased sweating \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0002014 \| Diarrhea \| 1 HP:0002861 \| Melanoma \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0003075 \| Hypoproteinemia \| 1 HP:0000992 \| Skin photosensitivity \| 1 HP:0002633 \| Vasculitis \| 1 HP:0012486 \| Inflammation of spinal cord \| 1 HP:0040189 \| Desquamation \| 1 HP:0002608 \| Celiac disease \| 1 HP:0100727 \| Histiocytosis \| 1 HP:0000975 \| Increased sweating \| 1 HP:0010783 \| Erythema \| 1 HP:0011123 \| Skin inflammation \| 1 HP:0100665 \| Angiooedema \| 1 HP:0008064 \| Ichthyosis \| 1 HP:0000739 \| Anxiety \| 1 HP:0004322 \| Stature below 3rd percentile \| 1 HP:0001045 \| Blotchy loss of skin color \| 1 HP:0000716 \| Depression \| 1 HP:0000100 \| Nephrosis \| 1 HP:0005432 \| Transient hypogammaglobulinemia of infancy \| 1 HP:0100633 \| Inflammation of the esophagus \| 1 HP:0002904 \| High blood bilirubin levels \| 1 HP:0002094 \| Dyspnea \| 1 HP:0011947 \| Respiratory infection \| 1 HP:0006579 \| Neonatal jaundice \| 1

Disease ID	880
Disease	dermatitis, atopic
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:36) C0033774 \| pruritus \| 33 C0002111 \| allergy \| 32 C0016470 \| food allergy \| 22 C0004096 \| asthma \| 15 C0037284 \| skin lesion \| 13 C0013595 \| eczema \| 10 C0021311 \| infections \| 9 C0009450 \| infection \| 8 C0033774 \| itching \| 7 C0037284 \| skin lesions \| 7 C0042109 \| urticaria \| 5 C0014457 \| eosinophilia \| 3 C1274788 \| atopic keratoconjunctivitis \| 3 C0586407 \| skin symptoms \| 3 C0037274 \| skin disease \| 2 C0011606 \| erythroderma \| 2 C0037278 \| skin infections \| 2 C0162820 \| allergic contact dermatitis \| 2 C0086543 \| cataracts \| 2 C0151908 \| skin dryness \| 2 C0035305 \| retinal detachment \| 2 C0037317 \| sleep disturbance \| 2 C0151908 \| dry skin \| 2 C0019360 \| zoster \| 1 C0011616 \| contact sensitivity \| 1 C0020757 \| ichthyosis \| 1 C0239816 \| hand eczema \| 1 C0026975 \| myelitis \| 1 C0026393 \| molluscum contagiosum \| 1 C0022504 \| kaposi's varicelliform eruption \| 1 C0041834 \| erythema \| 1 C0042900 \| vitiligo \| 1 C0037274 \| skin condition \| 1 C0037090 \| respiratory symptoms \| 1 C0025202 \| melanoma \| 1 C0016470 \| food hypersensitivity \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:78)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10995251	23042114	22891	ZNF365	umls:C0011615	GWASCAT	On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P(combined) = 8.36 × 10(-18)), the major histocompatibility complex (MHC) region (P = 8.38 × 10(-20)), OR10A3-NLRP10 (P = 1.54 × 10(-22)), GLB1 (P = 2.77 × 10(-16)), CCDC80 (P = 1.56 × 10(-19)), CARD11 (P = 7.83 × 10(-9)), ZNF365 (P = 5.85 × 10(-20)) and CYP24A1-PFDN4 (P = 1.65 × 10(-8)).	0.24	2012	ZNF365;LOC105378327	10	62638706	C	T
rs11079788	22303482	30009	TBX21	umls:C0011615	BeFree	TBX21 SNP rs11079788 carriers developed less symptoms of atopic dermatitis at 3 years of age (p = 0.03).	0.000542884	2012	TBX21	17	47743357	C	T
rs11558538	19025430	3176	HNMT	umls:C0011615	BeFree	Association of the histamine N-methyltransferase C314T (Thr105Ile) polymorphism with atopic dermatitis in Caucasian children.	0.005362824	2008	HNMT	2	138002079	C	T
rs11584340	25460639	4155	MBP	umls:C0011615	BeFree	After stratifying by phthalate metabolite levels, FLG P478S TT genotype was related to a higher odds of AD in children with high MBP levels (aOR=4.74, 95% CI 1.45-15.5) and in children with high MBzP levels (aOR=3.46, 95%CI 1.03-11.58).	0.002638474	2014	FLG;FLG-AS1	1	152313454	G	A
rs11584340	25460639	4153	MBL2	umls:C0011615	BeFree	After stratifying by phthalate metabolite levels, FLG P478S TT genotype was related to a higher odds of AD in children with high MBP levels (aOR=4.74, 95% CI 1.45-15.5) and in children with high MBzP levels (aOR=3.46, 95%CI 1.03-11.58).	0.005634266	2014	FLG;FLG-AS1	1	152313454	G	A
rs11584340	21219289	2312	FLG	umls:C0011615	BeFree	Our results suggest that the FLG P478S polymorphism may confer susceptibility to the development of AD among Chinese individuals and may be modified by IgE levels.	0.26434821	2011	FLG;FLG-AS1	1	152313454	G	A
rs11584340	25460639	5553	PRG2	umls:C0011615	BeFree	After stratifying by phthalate metabolite levels, FLG P478S TT genotype was related to a higher odds of AD in children with high MBP levels (aOR=4.74, 95% CI 1.45-15.5) and in children with high MBzP levels (aOR=3.46, 95%CI 1.03-11.58).	0.000271442	2014	FLG;FLG-AS1	1	152313454	G	A
rs12153855	23886662	7148	TNXB	umls:C0011615	GWASCAT	A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.	0.12	2014	TNXB	6	32107027	T	C
rs1295686	25574825	3596	IL13	umls:C0011615	GWASCAT	Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.	0.343136029	2014	IL13	5	132660151	T	C
rs1295686	23886662	3596	IL13	umls:C0011615	GWASCAT	We found considerable overlap between AD and psoriasis together with variable coincidence between allergic rhinitis (AR) and asthma.	0.343136029	2014	IL13	5	132660151	T	C
rs13015714	23042114	8809	IL18R1	umls:C0011615	GWASCAT	On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P(combined) = 8.36 × 10(-18)), the major histocompatibility complex (MHC) region (P = 8.38 × 10(-20)), OR10A3-NLRP10 (P = 1.54 × 10(-22)), GLB1 (P = 2.77 × 10(-16)), CCDC80 (P = 1.56 × 10(-19)), CARD11 (P = 7.83 × 10(-9)), ZNF365 (P = 5.85 × 10(-20)) and CYP24A1-PFDN4 (P = 1.65 × 10(-8)).	0.120271442	2012	IL18R1	2	102355405	G	T
rs13139310	22113474	3458	IFNG	umls:C0011615	BeFree	Eight IRF2 SNPs were significantly associated with IFN-γ production after herpes simplex virus (HSV) stimulation (P = 0.048-0.0008), including an AD-associated SNP (rs13139310, P = 0.008).	0.132234747	2012	IRF2	4	184435757	G	A
rs146466242	19663875	2312	FLG	umls:C0011615	BeFree	FLG mutation p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese patients with atopic eczema.	0.26434821	2009	FLG	1	152302822	T	A
rs148203517	25574825	102465537	MIR6891	umls:C0011615	GWASCAT	Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.	0.12	2014	NA	NA	NA	NA	NA
rs148203517	25574825	3106	HLA-B	umls:C0011615	GWASCAT	Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.	0.125276948	2014	NA	NA	NA	NA	NA
rs150597413	19874431	2312	FLG	umls:C0011615	BeFree	Analysis of four prevalent filaggrin mutations (R501X, 2282del4, R2447X and S3247X) in Austrian and German patients with atopic dermatitis.	0.26434821	2010	FLG	1	152305146	G	A,T
rs1665050	25865352	54778	RNF111	umls:C0011615	GWASCAT	A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis.	0.12	2015	RNF111	15	59001406	A	G
rs176095	23042114	5089	PBX2	umls:C0011615	GWASCAT	Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.	0.12	2012	PBX2;GPSM3	6	32190542	A	G
rs176095	25574825	5089	PBX2	umls:C0011615	GWASCAT	Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.	0.12	2014	PBX2;GPSM3	6	32190542	A	G
rs176095	25574825	63940	GPSM3	umls:C0011615	GWASCAT	Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.	0.12	2014	PBX2;GPSM3	6	32190542	A	G
rs176095	23042114	63940	GPSM3	umls:C0011615	GWASCAT	Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.	0.12	2012	PBX2;GPSM3	6	32190542	A	G
rs1800875	16134991	1215	CMA1	umls:C0011615	BeFree	Results confirm previous observations of a significant association between the CMA1 promoter polymorphism rs1800875 and atopic eczema, but not with serum IgE levels, and support the hypothesis that CMA1 serves as candidate gene for atopic eczema.	0.013006804	2005	CMA1	14	24510132	C	T
rs1800896	23857017	3586	IL10	umls:C0011615	BeFree	Association between the IL10 -1082A>G (rs1800896) single-nucleotide polymorphism and atopic dermatitis: a systematic review and meta-analysis.	0.138078323	2014	IL10	1	206773552	T	C
rs187238	22840759	3606	IL18	umls:C0011615	BeFree	This study was designed to investigate the association of the IL-18 gene SNPs (-137 G/C [rs187238], and -140 C/G [rs360721]) with AR and AD, as well as their relations to the diseases' severity.	0.097164308	2012	IL18	11	112164265	C	G
rs200519781	24858702	2312	FLG	umls:C0011615	BeFree	Filaggrin gene mutation c.3321delA is associated with various clinical features of atopic dermatitis in the Chinese Han population.	0.26434821	2014	FLG;FLG-AS1	1	152311565	T	-
rs2066446	20060272	3594	IL12RB1	umls:C0011615	BeFree	We showed that the rs438421 polymorphism in the IL-12RB1 (TT) gene and the rs2066446 polymorphism in the IL-12RB2 (AA) gene had a significant interaction to develop the ADe phenotype (allergic type of AD), and those individuals with the risk alleles, TT/AA/CC (IL-12RB1/IL-12RB2/IL-18), have more than a 10-fold increased risk to develop ADe.	0.008001298	2010	IL12RB2	1	67315434	A	G
rs2066446	20060272	3595	IL12RB2	umls:C0011615	BeFree	We showed that the rs438421 polymorphism in the IL-12RB1 (TT) gene and the rs2066446 polymorphism in the IL-12RB2 (AA) gene had a significant interaction to develop the ADe phenotype (allergic type of AD), and those individuals with the risk alleles, TT/AA/CC (IL-12RB1/IL-12RB2/IL-18), have more than a 10-fold increased risk to develop ADe.	0.002638474	2010	IL12RB2	1	67315434	A	G
rs2066446	20060272	3606	IL18	umls:C0011615	BeFree	We showed that the rs438421 polymorphism in the IL-12RB1 (TT) gene and the rs2066446 polymorphism in the IL-12RB2 (AA) gene had a significant interaction to develop the ADe phenotype (allergic type of AD), and those individuals with the risk alleles, TT/AA/CC (IL-12RB1/IL-12RB2/IL-18), have more than a 10-fold increased risk to develop ADe.	0.097164308	2010	IL12RB2	1	67315434	A	G
rs2155219	22036096	56946	C11orf30	umls:C0011615	BeFree	Variants in a locus near chromosome 11 open reading frame 30 (C11orf30) and leucine-rich repeat containing 32 (LRRC32), which was previously associated with atopic dermatitis and eczema, were also strongly associated with both phenotypes (rs2155219; P(grass) = 9.4 × 10(-9); P(AR) = 3.8 × 10(-8)).	0.122909916	2011	NA	11	76588150	G	T
rs2164983	22197932	81794	ADAMTS10	umls:C0011615	GAD	[Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.]	0.002367032	2012	NA	19	8679120	C	A
rs2251746	21738338	3497	IGHE	umls:C0011615	BeFree	In conclusion, while the 66T>C (rs2251746) of the FcεRIα polymorphism may be linked to AD and higher serum IgE levels, polymorphisms in the FcεRIβ gene did not confer susceptibility to AD in our patient sample.	0.003267234	2011	FCER1A	1	159302270	T	C
rs2271404	23042114	101927260	LOC101927260	umls:C0011615	GWASCAT	Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.	0.12	2012	LOC101927260	2	111246290	T	C
rs2303067	15005725	11005	SPINK5	umls:C0011615	BeFree	These results suggest that SPINK5 Glu420Lys polymorphism may be associated with certain asthma phenotypes characterized by the concomitant expression of asthma and atopic dermatitis or SPT reactivity.	0.019617217	2004	SPINK5	5	148101392	A	G
rs2303067	19438860	11005	SPINK5	umls:C0011615	BeFree	G1258A polymorphism in SPINK5 may be associated with atopic dermatitis, which shares several clinical features with NS.	0.019617217	2009	SPINK5	5	148101392	A	G
rs28665122	22069270	3606	IL18	umls:C0011615	BeFree	We genotyped single nucleotide polymorphisms (SNPs): -105/rs28665122 in SELS or SEPS1 (selenoprotein), three single nucleotide polymorphisms in IL18 (-105/rs360717, +183/rs5744292 and +1467/rs574456) and R501X/rs61816761 in FLG, the major locus associated with atopic dermatitis and predisposing to asthma, in a minimum of 6743 T1D cases and 7864 controls.	0.097164308	2011	VIMP	15	101277522	C	T
rs2897442	22197932	11127	KIF3A	umls:C0011615	GAD	[Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.]	0.123181358	2012	KIF3A	5	132713335	C	T
rs2897442	22197932	11127	KIF3A	umls:C0011615	GWASCAT	Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.	0.123181358	2012	KIF3A	5	132713335	C	T
rs3126085	21666691	339400	FLG-AS1	umls:C0011615	GWASCAT	Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population.	0.12	2011	FLG-AS1	1	152328341	G	A
rs334809	17620072	3568	IL5RA	umls:C0011615	BeFree	In the IL-5RA gene, the rs334809SNP showed a weak association with AD, and the rs6771148SNP and the haplotype T-C-T of the three adjacent tagged SNPs had an effect on the blood eosinophil counts and the serum ECP levels in the AD patients.	0.000271442	2007	IL5RA	3	3088537	A	T
rs360717	22069270	3606	IL18	umls:C0011615	BeFree	We genotyped single nucleotide polymorphisms (SNPs): -105/rs28665122 in SELS or SEPS1 (selenoprotein), three single nucleotide polymorphisms in IL18 (-105/rs360717, +183/rs5744292 and +1467/rs574456) and R501X/rs61816761 in FLG, the major locus associated with atopic dermatitis and predisposing to asthma, in a minimum of 6743 T1D cases and 7864 controls.	0.097164308	2011	IL18	11	112164002	G	A
rs360721	22840759	3606	IL18	umls:C0011615	BeFree	This study was designed to investigate the association of the IL-18 gene SNPs (-137 G/C [rs187238], and -140 C/G [rs360721]) with AR and AD, as well as their relations to the diseases' severity.	0.097164308	2012	IL18	11	112155193	G	C
rs3853601	22197932	7919	DDX39B	umls:C0011615	GAD	[Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.]	0.002367032	2012	DDX39B;ATP6V1G2-DDX39B	6	31531826	C	G
rs386430951	19874431	2312	FLG	umls:C0011615	BeFree	Analysis of four prevalent filaggrin mutations (R501X, 2282del4, R2447X and S3247X) in Austrian and German patients with atopic dermatitis.	0.26434821	2010	NA	NA	NA	NA	NA
rs41268896	25574825	7148	TNXB	umls:C0011615	GWASCAT	Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.	0.12	2014	TNXB	6	32102292	G	A
rs438421	20060272	3594	IL12RB1	umls:C0011615	BeFree	We showed that the rs438421 polymorphism in the IL-12RB1 (TT) gene and the rs2066446 polymorphism in the IL-12RB2 (AA) gene had a significant interaction to develop the ADe phenotype (allergic type of AD), and those individuals with the risk alleles, TT/AA/CC (IL-12RB1/IL-12RB2/IL-18), have more than a 10-fold increased risk to develop ADe.	0.008001298	2010	IL12RB1	19	18065276	A	G
rs438421	20060272	3595	IL12RB2	umls:C0011615	BeFree	We showed that the rs438421 polymorphism in the IL-12RB1 (TT) gene and the rs2066446 polymorphism in the IL-12RB2 (AA) gene had a significant interaction to develop the ADe phenotype (allergic type of AD), and those individuals with the risk alleles, TT/AA/CC (IL-12RB1/IL-12RB2/IL-18), have more than a 10-fold increased risk to develop ADe.	0.002638474	2010	IL12RB1	19	18065276	A	G
rs438421	20060272	3606	IL18	umls:C0011615	BeFree	We showed that the rs438421 polymorphism in the IL-12RB1 (TT) gene and the rs2066446 polymorphism in the IL-12RB2 (AA) gene had a significant interaction to develop the ADe phenotype (allergic type of AD), and those individuals with the risk alleles, TT/AA/CC (IL-12RB1/IL-12RB2/IL-18), have more than a 10-fold increased risk to develop ADe.	0.097164308	2010	IL12RB1	19	18065276	A	G
rs4674343	24730053	1593	CYP27A1	umls:C0011615	BeFree	A vitamin D-related SNP rs4674343 on CYP27A1 was found to be protective against atopic eczema.	0.000271442	2014	CYP27A1	2	218795623	A	G
rs479844	22197932	5017	OVOL1	umls:C0011615	GAD	[Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.]	0.122909916	2012	NA	11	65784486	A	G
rs4821544	22197932	4689	NCF4	umls:C0011615	GAD	[Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.]	0.002367032	2012	NCF4	22	36862461	T	C
rs5743618	24445834	7096	TLR1	umls:C0011615	BeFree	In this study, we demonstrated that TLR1 rs5743618 was associated with asthma and atopic eczema during the first 6 years of life after early bronchiolitis.	0.002909916	2014	TLR1	4	38797027	C	A
rs5743708	18234309	7097	TLR2	umls:C0011615	BeFree	The Toll-like receptor 2 R753Q mutation modifies cytokine production and Toll-like receptor expression in atopic dermatitis.	0.023894273	2008	TLR2	4	153705165	G	A
rs5743708	19849713	948	CD36	umls:C0011615	BeFree	Dysregulation of CD36 upon TLR-2 stimulation in monocytes from patients with atopic dermatitis and the TLR2 R753Q polymorphism.	0.000271442	2010	TLR2	4	153705165	G	A
rs5743708	19849713	7097	TLR2	umls:C0011615	BeFree	Dysregulation of CD36 upon TLR-2 stimulation in monocytes from patients with atopic dermatitis and the TLR2 R753Q polymorphism.	0.023894273	2010	TLR2	4	153705165	G	A
rs5743708	18445187	7097	TLR2	umls:C0011615	BeFree	Dysregulation of toll-like receptor-2 (TLR-2)-induced effects in monocytes from patients with atopic dermatitis: impact of the TLR-2 R753Q polymorphism.	0.023894273	2008	TLR2	4	153705165	G	A
rs5743810	24445834	10333	TLR6	umls:C0011615	BeFree	In addition, 11/60 (18%) children with TLR6 rs5743810 C/T versus 36/73 (49%) children of other genotypes had atopic eczema at follow up.	0.002909916	2014	TLR6	4	38828729	A	G
rs5744292	22069270	3606	IL18	umls:C0011615	BeFree	We genotyped single nucleotide polymorphisms (SNPs): -105/rs28665122 in SELS or SEPS1 (selenoprotein), three single nucleotide polymorphisms in IL18 (-105/rs360717, +183/rs5744292 and +1467/rs574456) and R501X/rs61816761 in FLG, the major locus associated with atopic dermatitis and predisposing to asthma, in a minimum of 6743 T1D cases and 7864 controls.	0.097164308	2011	IL18	11	112143413	T	C
rs574456	22069270	3606	IL18	umls:C0011615	BeFree	We genotyped single nucleotide polymorphisms (SNPs): -105/rs28665122 in SELS or SEPS1 (selenoprotein), three single nucleotide polymorphisms in IL18 (-105/rs360717, +183/rs5744292 and +1467/rs574456) and R501X/rs61816761 in FLG, the major locus associated with atopic dermatitis and predisposing to asthma, in a minimum of 6743 T1D cases and 7864 controls.	0.097164308	2011	LRP1B	2	140644133	A	T
rs61816761	22989708	2312	FLG	umls:C0011615	BeFree	Predictors of atopic dermatitis phenotypes and severity: roles of serum immunoglobulins and filaggrin gene mutation R501X.	0.26434821	2013	FLG;FLG-AS1	1	152313385	G	A,T
rs61816761	19874431	2312	FLG	umls:C0011615	BeFree	Analysis of four prevalent filaggrin mutations (R501X, 2282del4, R2447X and S3247X) in Austrian and German patients with atopic dermatitis.	0.26434821	2010	FLG;FLG-AS1	1	152313385	G	A,T
rs61816761	22069270	3606	IL18	umls:C0011615	BeFree	We genotyped single nucleotide polymorphisms (SNPs): -105/rs28665122 in SELS or SEPS1 (selenoprotein), three single nucleotide polymorphisms in IL18 (-105/rs360717, +183/rs5744292 and +1467/rs574456) and R501X/rs61816761 in FLG, the major locus associated with atopic dermatitis and predisposing to asthma, in a minimum of 6743 T1D cases and 7864 controls.	0.097164308	2011	FLG;FLG-AS1	1	152313385	G	A,T
rs61816761	21365004	2312	FLG	umls:C0011615	BeFree	In a Polish population FLG 2282del4 and R501X carriage increases risk for development of AD and atopic asthma (also in the absence of AD or history thereof).	0.26434821	2011	FLG;FLG-AS1	1	152313385	G	A,T
rs61816761	22283138	2312	FLG	umls:C0011615	BeFree	In total, 3202 adults aged 18-69 years were patch tested, filaggrin genotyped for 2282del4 and R501X and questioned about AD.	0.26434821	2012	FLG;FLG-AS1	1	152313385	G	A,T
rs6720763	25865352	100874011	XIRP2-AS1	umls:C0011615	GWASCAT	A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis.	0.12	2015	XIRP2;XIRP2-AS1	2	167135776	T	C
rs6720763	25865352	129446	XIRP2	umls:C0011615	GWASCAT	A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis.	0.12	2015	XIRP2;XIRP2-AS1	2	167135776	T	C
rs6771148	17620072	3568	IL5RA	umls:C0011615	BeFree	In the IL-5RA gene, the rs334809SNP showed a weak association with AD, and the rs6771148SNP and the haplotype T-C-T of the three adjacent tagged SNPs had an effect on the blood eosinophil counts and the serum ECP levels in the AD patients.	0.000271442	2007	IL5RA	3	3101583	G	C
rs7613051	23042114	2720	GLB1	umls:C0011615	GWASCAT	On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P(combined) = 8.36 × 10(-18)), the major histocompatibility complex (MHC) region (P = 8.38 × 10(-20)), OR10A3-NLRP10 (P = 1.54 × 10(-22)), GLB1 (P = 2.77 × 10(-16)), CCDC80 (P = 1.56 × 10(-19)), CARD11 (P = 7.83 × 10(-9)), ZNF365 (P = 5.85 × 10(-20)) and CYP24A1-PFDN4 (P = 1.65 × 10(-8)).	0.24	2012	GLB1	3	33023847	G	A
rs7815944	23042114	101927774	LINC00824	umls:C0011615	GWASCAT	Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.	0.12	2012	LINC00824	8	128415272	A	G
rs7927894	19349984	56946	C11orf30	umls:C0011615	GAD	[A common variant on chromosome 11q13 is associated with atopic dermatitis.]	0.122909916	2009	NA	11	76590272	C	T
rs7927894	23557745	388697	HRNR	umls:C0011615	BeFree	Recently, the two single nucleotide polymorphisms, rs7927894 on chromosome 11q13.5 and rs877776 within the region of the hornerin gene, were identified as novel susceptibility variants for atopic dermatitis in the first genome wide association study in atopic dermatitis.	0.003452799	2014	NA	11	76590272	C	T
rs7927894	20109745	388697	HRNR	umls:C0011615	BeFree	The first genome-wide association study in atopic eczema recently identified 2 novel genetic variants in association with eczema susceptibility: a single nucleotide polymorphism on chromosome 11q13.5 (rs7927894) and a single nucleotide polymorphism (rs877776) within the gene encoding hornerin on chromosome 1q21.	0.003452799	2010	NA	11	76590272	C	T
rs877776	20109745	388697	HRNR	umls:C0011615	BeFree	The first genome-wide association study in atopic eczema recently identified 2 novel genetic variants in association with eczema susceptibility: a single nucleotide polymorphism on chromosome 11q13.5 (rs7927894) and a single nucleotide polymorphism (rs877776) within the gene encoding hornerin on chromosome 1q21.	0.003452799	2010	NA	1	152205542	C	G
rs877776	23557745	388697	HRNR	umls:C0011615	BeFree	Recently, the two single nucleotide polymorphisms, rs7927894 on chromosome 11q13.5 and rs877776 within the region of the hornerin gene, were identified as novel susceptibility variants for atopic dermatitis in the first genome wide association study in atopic dermatitis.	0.003452799	2014	NA	1	152205542	C	G
rs895691	16374479	26151	NAT9	umls:C0011615	BeFree	In the MRC-E panel, rs895691, between the end of exon 6 of SLC9A3R1 and exon 7 of NAT9, was associated with AD (P = 0.037).	0.000271442	2006	NAT9	17	74770161	C	A
rs895691	16374479	9368	SLC9A3R1	umls:C0011615	BeFree	In the MRC-E panel, rs895691, between the end of exon 6 of SLC9A3R1 and exon 7 of NAT9, was associated with AD (P = 0.037).	0.000271442	2006	NAT9	17	74770161	C	A
rs909341	25574825	100533107	RTEL1-TNFRSF6B	umls:C0011615	GWASCAT	Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.	0.12	2014	TNFRSF6B;RTEL1-TNFRSF6B	20	63697389	C	T
rs941934	19133922	2312	FLG	umls:C0011615	BeFree	The CRNN polymorphism rs941934 was significantly associated with atopic eczema in the genetic analysis (P = 0.006), though only as part of an extended haplotype including a known associated variant (2282del4) in the filaggrin gene.	0.26434821	2009	NA	1	152417976	T	C
rs9469099	23042114	10665	C6orf10	umls:C0011615	GWASCAT	Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.	0.12	2012	C6orf10;LOC101929163	6	32341131	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:227)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	9194614	rs1001567	G	T	rs1001567	21625490	3.08E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
1	14221528	rs2697979	G	A	rs2697979	23042114	4.61E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	NA
1	18632801	rs11260978	A	G	rs11260978	21625490	3.91E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
1	55465594	rs759914	G	T	rs759914	21625490	6.16E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
1	65879252	rs10493377	A	G	rs10493377	21625490	7.81E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
1	152079314	rs9050	C	A	rs9050	23886662	3.91E-10	AD all	0.53	[0.37-0.7] unit increase	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs9050-A	Meta-Analysis	Research Support, Non-U.S. Gov't	G
1	152079314	rs9050	C	A	rs9050	23886662	4.00E-06	AD not asthma	0.48	[0.27-0.68] unit increase	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs9050-A	Meta-Analysis	Research Support, Non-U.S. Gov't	G
1	152079314	rs9050	C	A	rs9050	23886662	4.30E-07	AD and asthma	0.57	[0.35-0.79] unit increase	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs9050-A	Meta-Analysis	Research Support, Non-U.S. Gov't	G
1	152259078	rs11204971	A	G	rs11204971	21666691	5.02E-09	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
1	152300817	rs3126085	G	A	rs3126085	21666691	6.00E-12	NA	1.22	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs3126085-A	Research Support, Non-U.S. Gov't	Comparative Study	A
1	152442289	rs6661961	T	C	rs6661961	23886662	9.00E-11	NA	0.34	[0.24-0.44] unit increase	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs6661961-T	Meta-Analysis	Research Support, Non-U.S. Gov't	T
1	166974420	rs1041238	T	C	rs1041238	21625490	6.08E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	T
1	166982285	rs12133327	A	G	rs12133327	21625490	5.63E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
1	179958809	rs2501618	T	C	rs2501618	19961619	1.30E-07	NA	NA	NA	75 European atopy and asthma cases; 75 European atopy only cases; 75 European controls	European(225)	ALL(225)	EUR(225)	ALL(225)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	G	CEP350
1	198393815	rs12078566	G	A	rs12078566	21666691	2.95E-04	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
1	198417004	rs12085366	T	C	rs12085366	21666691	1.46E-05	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
2	750078	rs4335978	A	G	rs4335978	23042114	9.77E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	NA
2	4325172	rs6716364	C	T	rs6716364	21625490	2.23E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
2	6703089	rs1350342	G	A	rs1350342	21625490	3.09E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
2	42276921	rs4952590	C	T	rs4952590	19961619	2.00E-06	NA	1.92	[1.27-2.86]	75 European atopy and asthma cases; 75 European atopy only cases; 75 European controls	European(225)	ALL(225)	EUR(225)	ALL(225)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	T	PKDCC
2	70213304	rs116939658	C	T	rs116939658	23042114	2.76E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	C	PCBP1-AS1
2	70291839	rs117950954	G	A	rs117950954	23042114	5.25E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	PCBP1-AS1
2	71068623	rs17006471	T	C	rs17006471	23886662	1.11E-08	NA	1.25	[1.16-1.35]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs17006471-C	Meta-Analysis	Research Support, Non-U.S. Gov't	T
2	71090525	rs10167243	A	G	rs10167243	23042114	7.88E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	NA
2	102971865	rs13015714	G	T	rs13015714	23042114	8.00E-18	NA	1.27	[1.20-1.34]	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs13015714-G	Research Support, Non-U.S. Gov't	T	NA
2	112003867	rs2271404	T	C	rs2271404	23042114	3.00E-07	NA	1.17	[1.10-1.25]	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs2271404-G	Research Support, Non-U.S. Gov't	A	LOC100505634
2	134128159	rs2289076	G	A	rs2289076	21625490	5.07E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
2	137087324	rs13003740	A	G	rs13003740	23042114	8.76E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	NA
2	137087576	rs5011377	A	G	rs5011377	23042114	9.95E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A,G	NA
2	151218033	rs6760903	G	A	rs6760903	21666691	3.57E-05	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
2	163417299	rs10439292	G	A	rs10439292	23042114	9.58E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	KCNH7
2	163420104	rs17401811	A	T	rs17401811	23042114	5.62E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	T	KCNH7
2	163420361	rs13002126	T	C	rs13002126	23042114	6.14E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	C	KCNH7
2	163420535	rs1843553	C	T	rs1843553	23042114	6.16E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	KCNH7
2	163421016	rs10497226	G	C	rs10497226	23042114	6.18E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	KCNH7
2	163422403	rs13403935	T	C	rs13403935	23042114	8.55E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	C	KCNH7
2	240463182	rs62180959	T	C	rs62180959	23042114	9.18E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	T	NA
2	240467250	rs7571310	T	A	rs7571310	23042114	8.35E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	T	NA
2	240468521	rs62183061	G	A	rs62183061	23042114	8.33E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	NA
2	240468671	rs62183062	A	T	rs62183062	23042114	8.44E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	NA
2	240469892	rs55814338	G	A	rs55814338	23042114	9.82E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	NA
3	16422989	rs9310496	A	G	rs9310496	21625490	1.02E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
3	33065339	rs7613051	G	A	rs7613051	23042114	6.00E-21	NA	1.29	[1.22-1.36]	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs7613051-A	Research Support, Non-U.S. Gov't	A	GLB1
3	35368128	rs4678766	G	A	rs4678766	23042114	8.07E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	NA
3	112376308	rs12634229	T	C	rs12634229	23042114	2.00E-19	NA	1.29	[1.22-1.37]	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs12634229-G	Research Support, Non-U.S. Gov't	T	NA
3	130159934	rs7629719	G	T	rs7629719	19961619	1.20E-07	NA	NA	NA	75 European atopy and asthma cases; 75 European atopy only cases; 75 European controls	European(225)	ALL(225)	EUR(225)	ALL(225)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	T	COL6A5
3	159952278	rs6441306	A	G	rs6441306	21625490	9.73E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
3	183481246	rs6443904	A	G	rs6443904	21625490	4.91E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
4	34561689	rs1480990	C	T	rs1480990	21625490	9.04E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C,T
4	118869326	rs10034085	G	T	rs10034085	21625490	1.04E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	T
5	20940129	rs9292961	G	A	rs9292961	19961619	5.30E-07	NA	NA	NA	75 European atopy and asthma cases; 75 European atopy only cases; 75 European controls	European(225)	ALL(225)	EUR(225)	ALL(225)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	A	NA
5	78369901	rs626105	A	G	rs626105	21625490	1.20E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
5	96130836	rs26618	T	A,C,G	rs26618	21666691	4.83E-04	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	T
5	96155608	rs18036	T	C	rs18036	21666691	3.01E-04	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
5	109826296	rs10067777	A	G	rs10067777	21666691	6.32E-08	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
5	109858821	rs7701890	A	G	rs7701890	21666691	4.33E-08	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
5	110035756	rs13360927	A	G	rs13360927	21666691	2.80E-07	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
5	110048954	rs13361382	G	A	rs13361382	21666691	2.09E-07	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
5	131929594	rs2897443	G	T	rs2897443	23886662	8.95E-13	NA	1.31	[1.22-1.41]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs2897443-T	Meta-Analysis	Research Support, Non-U.S. Gov't	C
5	131969874	rs6871536	T	C	rs6871536	23886662	2.11E-15	NA	1.35	[1.25-1.45]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs6871536-C	Meta-Analysis	Research Support, Non-U.S. Gov't	T
5	131984058	rs2158177	A	G	rs2158177	23886662	5.90E-11	NA	1.42	[1.28-1.58]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs2158177-G	Meta-Analysis	Research Support, Non-U.S. Gov't	A
5	131995843	rs1295686	T	C	rs1295686	23042114	2.00E-06	NA	1.22	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs1295686-T	Research Support, Non-U.S. Gov't	A	IL13
5	131995843	rs1295686	T	C	rs1295686	23886662	2.00E-17	NA	1.38	[1.28-1.49]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs1295686-A	Meta-Analysis	Research Support, Non-U.S. Gov't	A
5	131995964	rs20541	A	G	rs20541	23886662	1.79E-08	AD and psoriasis	0.35	[0.23-0.48] unit increase	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs20541-A	Meta-Analysis	Research Support, Non-U.S. Gov't	C
5	131995964	rs20541	A	G	rs20541	23886662	1.93E-14	NA	1.39	[1.28-1.51]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs20541-A	Meta-Analysis	Research Support, Non-U.S. Gov't	C
5	131996445	rs1295685	A	G	rs1295685	23886662	4.94E-09	AD and psoriasis	0.38	[0.25-0.51] unit increase	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs1295685-A	Meta-Analysis	Research Support, Non-U.S. Gov't	C
5	131999494	rs2243204	C	T	rs2243204	23886662	1.30E-05	NA	1.43	[1.22-1.68]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs2243204-T	Meta-Analysis	Research Support, Non-U.S. Gov't	T
5	132049027	rs2897442	C	T	rs2897442	22197932	4.00E-08	NA	1.11	[1.07-1.15]	5,606 European ancestry cases; 20,565 European ancestry controls	European(26171)	ALL(26171)	EUR(26171)	ALL(26171)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs2897442-C	Meta-Analysis	A	KIF3A
5	132049027	rs2897442	C	T	rs2897442	23886662	1.18E-04	AD all	0.22	[0.11-0.33] unit decrease	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs2897442-T	Meta-Analysis	Research Support, Non-U.S. Gov't	A
5	136221582	rs17702421	A	C	rs17702421	21625490	7.09E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
5	143275201	rs2112197	T	C	rs2112197	21625490	2.85E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
5	149459574	rs13188584	C	T	rs13188584	21625490	1.78E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
6	209462	rs17133789	T	G	rs17133789	21625490	2.13E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	T
6	26558531	rs9295697	T	C	rs9295697	23042114	7.41E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	C	NA
6	31272321	rs9368677	G	A	rs9368677	23042114	1.00E-17	NA	1.36	[1.27-1.46]	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs9368677-G	Research Support, Non-U.S. Gov't	G	NA
6	31364707	rs2251396	G	A	rs2251396	23886662	1.28E-09	NA	1.27	[1.17-1.37]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs2251396-A	Meta-Analysis	Research Support, Non-U.S. Gov't	C
6	31499603	rs3853601	C	G	rs3853601	22197932	2.00E-06	NA	1.13	[1.08-1.19]	5,606 European ancestry cases; 20,565 European ancestry controls	European(26171)	ALL(26171)	EUR(26171)	ALL(26171)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs3853601-G	Meta-Analysis	G	DDX39B
6	31510924	rs2844509	A	G	rs2844509	23886662	4.33E-12	NA	1.31	[1.22-1.42]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs2844509-A	Meta-Analysis	Research Support, Non-U.S. Gov't	T
6	31544189	rs3093662	A	G	rs3093662	23886662	8.07E-06	NA	1.42	[1.22-1.66]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs3093662-A	Meta-Analysis	Research Support, Non-U.S. Gov't	A
6	31553194	rs9267502	G	A	rs9267502	23886662	8.22E-04	NA	1.37	[1.14-1.65]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs9267502-G	Meta-Analysis	Research Support, Non-U.S. Gov't	A
6	31572927	rs9378200	T	C	rs9378200	23886662	1.84E-05	NA	1.45	[1.22-1.72]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs9378200-T	Meta-Analysis	Research Support, Non-U.S. Gov't	T
6	31802541	rs9368699	T	C	rs9368699	23886662	3.19E-08	NA	1.68	[1.40-2.01]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs9368699-T	Meta-Analysis	Research Support, Non-U.S. Gov't	T
6	31946614	rs6941112	G	A	rs6941112	23886662	1.95E-05	NA	1.23	[1.12-1.36]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs6941112-A	Meta-Analysis	Research Support, Non-U.S. Gov't	G
6	32026808	rs12198173	G	A	rs12198173	23886662	1.33E-10	NA	1.51	[1.33-1.71]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs12198173-G	Meta-Analysis	Research Support, Non-U.S. Gov't	G
6	32049423	rs12211410	C	T	rs12211410	23886662	5.78E-10	NA	1.45	[1.29-1.63]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs12211410-C	Meta-Analysis	Research Support, Non-U.S. Gov't	C
6	32066765	rs13199524	C	T	rs13199524	23886662	8.01E-12	NA	1.56	[1.37-1.77]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs13199524-C	Meta-Analysis	Research Support, Non-U.S. Gov't	C
6	32074804	rs12153855	T	C	rs12153855	23886662	3.00E-14	NA	1.58	[1.41-1.78]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs12153855-T	Meta-Analysis	Research Support, Non-U.S. Gov't	T
6	32158319	rs176095	A	G	rs176095	23042114	8.00E-20	NA	1.4	[1.30-1.51]	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs176095-T	Research Support, Non-U.S. Gov't	T	NA
6	32158319	rs176095	A	G	rs176095	23886662	4.63E-04	AD not asthma	0.31	[0.14-0.49] unit increase	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs176095-A	Meta-Analysis	Research Support, Non-U.S. Gov't	T
6	32192107	rs3134929	C	G	rs3134929	23886662	7.06E-06	NA	1.33	[1.17-1.50]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs3134929-C	Meta-Analysis	Research Support, Non-U.S. Gov't	G
6	32308908	rs9469099	G	A	rs9469099	23042114	5.00E-19	NA	1.61	[1.44-1.80]	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs9469099-G	Research Support, Non-U.S. Gov't	G	C6orf10
6	32665728	rs9275312	A	G	rs9275312	21625490	9.25E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
6	32666822	rs9275328	C	T	rs9275328	21625490	9.40E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
6	136992379	rs9376221	T	C	rs9376221	19961619	3.90E-07	NA	NA	NA	75 European atopy and asthma cases; 75 European atopy only cases; 75 European controls	European(225)	ALL(225)	EUR(225)	ALL(225)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	T	MAP3K5
6	149793025	rs512685	G	A	rs512685	21666691	3.94E-09	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	A,G
6	154597660	rs17085260	C	A	rs17085260	21625490	7.54E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
7	3128789	rs4722404	T	C	rs4722404	23042114	8.00E-09	NA	1.18	[1.12-1.25]	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs4722404-G	Research Support, Non-U.S. Gov't	T	NA
7	7040176	rs4074751	G	T	rs4074751	21625490	3.20E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
7	24631245	rs4722378	T	C	rs4722378	21625490	7.67E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	T
7	24637056	rs12700538	G	A	rs12700538	21625490	6.00E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
7	24759648	rs2237310	A	C	rs2237310	21625490	1.11E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
7	24761850	rs2237315	G	T	rs2237315	21625490	9.09E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	T
7	34777714	rs324389	C	T	rs324389	21625490	1.45E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	T
7	34786398	rs10270663	G	T	rs10270663	21625490	9.96E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
7	34803103	rs10267134	A	G	rs10267134	21625490	1.03E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
7	34808471	rs10278663	G	A	rs10278663	21625490	4.36E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
7	34832301	rs325452	G	T	rs325452	23042114	6.93E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	NPSR1
7	83777151	rs73177474	T	C	rs73177474	23042114	5.38E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	T	SEMA3A
7	83778559	rs73177481	A	T	rs73177481	23042114	5.32E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	SEMA3A
7	110494399	rs6948090	A	G	rs6948090	21625490	2.87E-06	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
7	110509136	rs799623	C	T	rs799623	21625490	6.71E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
7	110635497	rs4727753	A	G	rs4727753	21625490	8.64E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
7	110670551	rs7801774	T	G	rs7801774	21625490	1.09E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
7	137600690	rs273957	C	A,G,T	rs273957	21625490	6.69E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	T
7	145327959	rs11761986	G	T	rs11761986	21625490	1.65E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
7	151268920	rs17173197	C	T	rs17173197	21666691	1.39E-07	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	T
8	3612816	rs13264640	G	C	rs13264640	23042114	4.74E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	CSMD1
8	3623014	rs1994056	C	A	rs1994056	23042114	5.17E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	CSMD1
8	3625407	rs62479698	G	A	rs62479698	23042114	3.36E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	CSMD1
8	6774414	rs2738133	G	A	rs2738133	21625490	1.95E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	T
8	27328511	rs2472553	G	A	rs2472553	21625490	6.22E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
8	33115544	rs7843085	G	A	rs7843085	19961619	3.93E-07	NA	NA	NA	75 European atopy and asthma cases; 75 European atopy only cases; 75 European controls	European(225)	ALL(225)	EUR(225)	ALL(225)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	G	NA
8	33126999	rs13273924	T	G	rs13273924	19961619	7.50E-07	NA	NA	NA	75 European atopy and asthma cases; 75 European atopy only cases; 75 European controls	European(225)	ALL(225)	EUR(225)	ALL(225)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	G	NA
8	59308732	rs7835920	T	G	rs7835920	21094521	5.54E-07	Increased specific IgE levels	NA	NA	1083 United Kingdom cases; 2770 United Kingdom controls	United Kingdom(3853)	ALL(3853)	EUR(3853)	ALL(3853)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
8	59308732	rs7835920	T	G	rs7835920	21094521	5.79E-04	Total serum IgE (ln)	NA	NA	1083 United Kingdom cases; 2770 United Kingdom controls	United Kingdom(3853)	ALL(3853)	EUR(3853)	ALL(3853)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
8	59386354	rs17202769	T	C	rs17202769	21094521	1.39E-06	Increased specific IgE levels	NA	NA	1083 United Kingdom cases; 2770 United Kingdom controls	United Kingdom(3853)	ALL(3853)	EUR(3853)	ALL(3853)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
8	81308150	rs7000782	T	A	rs7000782	22197932	1.00E-06	NA	1.09	[1.05-1.13]	5,606 European ancestry cases; 20,565 European ancestry controls	European(26171)	ALL(26171)	EUR(26171)	ALL(26171)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs7000782-A	Meta-Analysis	A	NA
8	101573820	rs7835153	A	G	rs7835153	21094521	3.47E-05	Total serum IgE (ln)	NA	NA	1083 United Kingdom cases; 2770 United Kingdom controls	United Kingdom(3853)	ALL(3853)	EUR(3853)	ALL(3853)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
8	101573820	rs7835153	A	G	rs7835153	21094521	4.50E-07	Increased specific IgE levels	NA	NA	1083 United Kingdom cases; 2770 United Kingdom controls	United Kingdom(3853)	ALL(3853)	EUR(3853)	ALL(3853)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
8	123817944	rs10505427	G	A	rs10505427	21625490	5.95E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
8	129427518	rs7815944	A	G	rs7815944	23042114	4.00E-07	NA	1.16	[1.10-1.23]	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs7815944-A	Research Support, Non-U.S. Gov't	A	NA
8	134587501	rs1464241	T	C	rs1464241	23042114	8.33E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	NA
8	134587859	rs2945723	C	T	rs2945723	23042114	3.46E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	NA
8	134589010	rs4270941	C	G,T	rs4270941	23042114	3.95E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	C	NA
8	134589233	rs2404005	A	T	rs2404005	23042114	4.64E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	T	NA
8	134590311	rs11984457	T	A	rs11984457	23042114	7.73E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	NA
8	134590512	rs11984505	T	A	rs11984505	23042114	8.79E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	NA
9	34261117	rs7020934	T	C	rs7020934	21625490	4.64E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	T
9	138417830	rs13284515	C	T	rs13284515	21625490	3.36E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
10	6022795	rs8177617	G	A	rs8177617	23042114	8.56E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	C	NA
10	64369001	rs2393902	T	C	rs2393902	23886662	2.00E-04	NA	1.2	[1.09-1.32]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs2393902-C	Meta-Analysis	Research Support, Non-U.S. Gov't	T
10	64380336	rs2393903	T	C	rs2393903	21666691	1.05E-07	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
10	64384782	rs10761650	G	A	rs10761650	21666691	2.90E-05	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
10	64398466	rs10995251	C	T	rs10995251	23042114	6.00E-20	NA	1.28	[1.22-1.36]	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs10995251-C	Research Support, Non-U.S. Gov't	C	ZNF365
10	64560470	rs1444418	A	G	rs1444418	23042114	2.00E-07	NA	1.17	[1.10-1.24]	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs1444418-A	Research Support, Non-U.S. Gov't	C	NA
10	98521516	rs505010	C	T	rs505010	21625490	1.19E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	T
10	121417358	rs196342	A	G	rs196342	21625490	7.09E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
10	122829617	rs11199746	A	G	rs11199746	21625490	2.40E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
10	122857963	rs10886849	C	T	rs10886849	21625490	2.81E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
10	126036778	rs11244450	C	T	rs11244450	21094521	2.14E-04	Total serum IgE (ln)	NA	NA	1083 United Kingdom cases; 2770 United Kingdom controls	United Kingdom(3853)	ALL(3853)	EUR(3853)	ALL(3853)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
10	126036778	rs11244450	C	T	rs11244450	21094521	6.50E-06	Increased specific IgE levels	NA	NA	1083 United Kingdom cases; 2770 United Kingdom controls	United Kingdom(3853)	ALL(3853)	EUR(3853)	ALL(3853)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
11	6026661	rs4573661	G	A	rs4573661	21625490	4.35E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
11	7968359	rs878860	C	T	rs878860	23042114	2.00E-22	NA	1.31	[1.24-1.38]	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs878860-G	Research Support, Non-U.S. Gov't	C	NA
11	36371757	rs2592555	T	C	rs2592555	23042114	7.54E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	PRR5L
11	47417183	rs10769263	A	C	rs10769263	23042114	6.95E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	NA
11	47418953	rs874896	C	G,T	rs874896	23042114	4.83E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	NA
11	47419663	rs1534576	G	T	rs1534576	23042114	4.43E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	NA
11	60178610	rs7106239	T	C	rs7106239	23042114	4.41E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	C	MS4A14
11	60190374	rs1596313	A	G	rs1596313	23042114	4.01E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	NA
11	61800812	rs11230882	G	A	rs11230882	21625490	1.62E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
11	65513107	rs593982	T	C	rs593982	23042114	6.00E-07	NA	1.23	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs593982-C	Research Support, Non-U.S. Gov't	G	NA
11	65551957	rs479844	A	G	rs479844	22197932	1.00E-13	NA	1.14	[1.10-1.18]	5,606 European ancestry cases; 20,565 European ancestry controls	European(26171)	ALL(26171)	EUR(26171)	ALL(26171)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs479844-G	Meta-Analysis	C	NA
11	65551957	rs479844	A	G	rs479844	23886662	2.77E-05	AD all	0.22	[0.12-0.32] unit decrease	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs479844-A	Meta-Analysis	Research Support, Non-U.S. Gov't	C
11	65676516	rs653914	A	G	rs653914	21666691	2.69E-04	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
11	76270683	rs7130588	A	G	rs7130588	23886662	1.71E-04	AD and asthma	0.27	[0.13-0.42] unit decrease	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs7130588-A	Meta-Analysis	Research Support, Non-U.S. Gov't	A
11	76270683	rs7130588	A	G	rs7130588	23886662	3.94E-05	AD not asthma	0.26	[0.14-0.39] unit decrease	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs7130588-A	Meta-Analysis	Research Support, Non-U.S. Gov't	A
11	76270683	rs7130588	A	G	rs7130588	23886662	4.00E-13	NA	1.29	[1.20-1.38]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs7130588-G	Meta-Analysis	Research Support, Non-U.S. Gov't	A
11	76270683	rs7130588	A	G	rs7130588	23886662	5.81E-07	AD all	0.26	[0.16-0.36] unit decrease	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs7130588-A	Meta-Analysis	Research Support, Non-U.S. Gov't	A
11	76278258	rs7936562	T	C	rs7936562	21666691	4.25E-04	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
11	76299194	rs2155219	G	T	rs2155219	23886662	1.61E-12	NA	1.32	[1.22-1.43]	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs2155219-T	Meta-Analysis	Research Support, Non-U.S. Gov't	T
11	76301316	rs7927894	C	T	rs7927894	19349984	8.00E-10	NA	1.22	[1.15-1.30]	939 cases; 975 controls; 1,097 family members	NOPOP(3011)	ALL(3011)	NOPOP(3011)	ALL(3011)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs7927894-A	Research Support, Non-U.S. Gov't	C	NA
11	76301316	rs7927894	C	T	rs7927894	23886662	1.73E-06	AD all	0.26	[0.15-0.37] unit increase	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs7927894-T	Meta-Analysis	Research Support, Non-U.S. Gov't	C
11	76301316	rs7927894	C	T	rs7927894	23886662	2.10E-04	AD and asthma	0.28	[0.13-0.43] unit increase	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs7927894-T	Meta-Analysis	Research Support, Non-U.S. Gov't	C
11	76301316	rs7927894	C	T	rs7927894	23886662	9.80E-05	AD not asthma	0.26	[0.13-0.39] unit increase	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs7927894-T	Meta-Analysis	Research Support, Non-U.S. Gov't	C
11	76332210	rs11236809	T	G	rs11236809	23042114	3.00E-06	NA	1.24	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs11236809-G	Research Support, Non-U.S. Gov't	T	NA
11	87375501	rs17822261	C	T	rs17822261	21625490	9.59E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
11	126753631	rs4936003	T	C	rs4936003	21094521	4.20E-05	Increased specific IgE levels	NA	NA	1083 United Kingdom cases; 2770 United Kingdom controls	United Kingdom(3853)	ALL(3853)	EUR(3853)	ALL(3853)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
11	126753631	rs4936003	T	C	rs4936003	21094521	7.33E-04	Positive skin prick test	NA	NA	1083 United Kingdom cases; 2770 United Kingdom controls	United Kingdom(3853)	ALL(3853)	EUR(3853)	ALL(3853)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
12	7340994	rs12312641	G	A	rs12312641	21625490	1.21E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
12	29918319	rs12231167	T	C	rs12231167	23042114	5.52E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	T	TMTC1
12	29919461	rs4931215	A	G	rs4931215	23042114	5.43E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	TMTC1
12	29920088	rs11609828	A	G	rs11609828	23042114	5.40E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	TMTC1
12	29920111	rs10843501	T	C	rs10843501	23042114	4.70E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	C	TMTC1
12	29920117	rs10843502	T	C	rs10843502	23042114	5.99E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	C,T	TMTC1
12	29920318	rs10843503	T	C	rs10843503	23042114	5.34E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	C	TMTC1
12	29920420	rs10771579	G	C	rs10771579	23042114	5.32E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	C	TMTC1
12	29920565	rs10743672	G	A	rs10743672	23042114	5.29E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	TMTC1
12	29920569	rs10743673	G	T	rs10743673	23042114	5.28E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	T	TMTC1
12	29921735	rs4931216	A	G	rs4931216	23042114	5.22E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	TMTC1
12	29922051	rs7967779	G	C	rs7967779	23042114	4.40E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	TMTC1
12	29922821	rs4931217	A	T	rs4931217	23042114	4.39E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	TMTC1
12	29923853	rs4931218	G	C	rs4931218	23042114	5.09E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	G	TMTC1
12	29923876	rs4931219	T	A	rs4931219	23042114	5.06E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	T	TMTC1
12	29925233	rs4931220	C	A	rs4931220	23042114	4.96E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	C	TMTC1
12	29925273	rs4244848	A	G	rs4244848	23042114	4.94E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	TMTC1
12	29925484	rs4244849	T	A	rs4244849	23042114	4.89E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	T	TMTC1
12	29926132	rs10843504	G	A	rs10843504	23042114	4.87E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	TMTC1
12	29926776	rs2882467	A	G	rs2882467	23042114	4.85E-05	NA	NA	NA	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	A	TMTC1
12	95324389	rs249153	T	C	rs249153	21625490	1.18E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
12	111536822	rs1001484	A	G	rs1001484	21625490	4.47E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
13	49753729	rs6561505	G	A	rs6561505	21094521	2.15E-09	Increased specific IgE levels	NA	NA	1083 United Kingdom cases; 2770 United Kingdom controls	United Kingdom(3853)	ALL(3853)	EUR(3853)	ALL(3853)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
13	49753729	rs6561505	G	A	rs6561505	21094521	7.75E-05	Total serum IgE (ln)	NA	NA	1083 United Kingdom cases; 2770 United Kingdom controls	United Kingdom(3853)	ALL(3853)	EUR(3853)	ALL(3853)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
14	54164706	rs210360	C	T	rs210360	21625490	6.12E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	T
16	11210415	rs9923856	T	C	rs9923856	23042114	6.00E-06	NA	1.17	[1.09-1.25]	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs9923856-A	Research Support, Non-U.S. Gov't	C	CLEC16A
17	38062196	rs2305480	G	A	rs2305480	23886662	5.79E-05	AD and asthma	0.29	[0.15-0.43] unit decrease	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs2305480-A	Meta-Analysis	Research Support, Non-U.S. Gov't	C
17	38064405	rs11078927	C	T	rs11078927	23886662	5.44E-05	AD and asthma	0.29	[0.15-0.43] unit decrease	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs11078927-T	Meta-Analysis	Research Support, Non-U.S. Gov't	C
17	38121993	rs3894194	G	A	rs3894194	23886662	9.60E-05	AD and asthma	0.28	[0.14-0.41] unit increase	1563 European ancestry cases; 4,054 European ancestry controls	European(5617)	ALL(5617)	EUR(5617)	ALL(5617)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs3894194-A	Meta-Analysis	Research Support, Non-U.S. Gov't	C
18	2635263	rs2044107	A	G	rs2044107	21625490	5.24E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
18	45298230	rs2852950	G	A	rs2852950	21625490	1.86E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
18	45363289	rs8085335	A	G	rs8085335	21625490	3.52E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
18	55811058	rs878396	G	A	rs878396	21625490	3.85E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
18	70421051	rs10514054	C	A	rs10514054	21094521	2.54E-05	Increased specific IgE levels	NA	NA	1083 United Kingdom cases; 2770 United Kingdom controls	United Kingdom(3853)	ALL(3853)	EUR(3853)	ALL(3853)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
19	8789381	rs2164983	C	A	rs2164983	22197932	7.00E-09	NA	1.16	[1.10-1.22]	5,606 European ancestry cases; 20,565 European ancestry controls	European(26171)	ALL(26171)	EUR(26171)	ALL(26171)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs2164983-A	Meta-Analysis	C	NA
19	10260869	rs9305012	T	C	rs9305012	21625490	8.52E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
19	10368050	rs8111930	A	G	rs8111930	21625490	8.69E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
19	45150614	rs1058402	G	A	rs1058402	21625490	7.38E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
20	2166427	rs6082335	T	C	rs6082335	21094521	2.78E-05	Increased specific IgE levels	NA	NA	1083 United Kingdom cases; 2770 United Kingdom controls	United Kingdom(3853)	ALL(3853)	EUR(3853)	ALL(3853)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
20	33452600	rs17122844	C	T	rs17122844	21625490	1.62E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	T
20	33594226	rs6060151	G	T	rs6060151	21625490	7.73E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
20	33667560	rs2145557	A	G	rs2145557	21625490	8.13E-05	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	A
20	52807221	rs16999165	A	G	rs16999165	23042114	2.00E-08	NA	1.19	[1.12-1.26]	1,472 Japanese ancestry cases; 7,971 Japanese ancestry controls	Japanese(9443)	ALL(9443)	ASN(9443)	ALL(9443)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs16999165-T	Research Support, Non-U.S. Gov't	G	NA
20	62309839	rs6010620	A	G	rs6010620	21666691	3.00E-08	NA	NA	NA	1,012 Han Chinese cases; 1,362 Han Chinese controls	Han Chinese(2374)	ALL(2374)	ASN(2374)	ALL(2374)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	NA	Research Support, Non-U.S. Gov't	Comparative Study	G
21	15955911	rs2822793	C	T	rs2822793	21625490	3.73E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	T
21	22892128	rs2826877	C	T	rs2826877	21625490	1.54E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
21	41031610	rs2837108	C	T	rs2837108	21625490	1.05E-04	NA	NA	NA	515 Chinese ancestry cases; 486 Chinese ancestry controls	Chinese(1001)	ALL(1001)	ASN(1001)	ALL(1001)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	Comparative Study	C
21	46953292	rs2330183	C	T	rs2330183	19961619	1.59E-07	NA	NA	NA	75 European atopy and asthma cases; 75 European atopy only cases; 75 European controls	European(225)	ALL(225)	EUR(225)	ALL(225)	Atopy	HPOID:0001047	Atopic dermatitis	DOID:0060056	hypersensitivity reaction disease	D006969	Hypersensitivity, Immediate	NA	NA	Immunologic deficiency syndrome	NA	Research Support, Non-U.S. Gov't	C	SLC19A1
22	37258503	rs4821544	T	C	rs4821544	22197932	6.00E-06	NA	1.09	[1.05-1.13]	5,606 European ancestry cases; 20,565 European ancestry controls	European(26171)	ALL(26171)	EUR(26171)	ALL(26171)	Atopic dermatitis	HPOID:0001047	Atopic dermatitis	DOID:3310	atopic dermatitis	D003876	Dermatitis, Atopic	EFOID:0000274	atopic eczema	Dermatitis	rs4821544-C	Meta-Analysis	C	NCF4

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:8)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0011615	azelaic acid	C010038	-	dermatitis, atopic	MESH:D003876	therapeutic	19804495
C0011615	betamethasone	D001623	378-44-9	dermatitis, atopic	MESH:D003876	therapeutic	11692113
C0011615	cyclophosphamide	D003520	50-18-0	dermatitis, atopic	MESH:D003876	marker/mechanism	22842586
C0011615	pimecrolimus	C117268	-	dermatitis, atopic	MESH:D003876	therapeutic	12093983
C0011615	rosiglitazone	C089730	-	dermatitis, atopic	MESH:D003876	therapeutic	18209172
C0011615	tacrolimus	D016559	109581-93-3	dermatitis, atopic	MESH:D003876	therapeutic	10497905
C0011615	thalidomide	D013792	50-35-1	dermatitis, atopic	MESH:D003876	therapeutic	19548950
C0011615	zafirlukast	C062735	107753-78-6	dermatitis, atopic	MESH:D003876	therapeutic	11901593

FDA approved drug and dosage information(Total Drugs:1)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D003876	elidel	pimecrolimus	1%	CREAM;TOPICAL	Prescription	None	Yes	Yes

FDA labeling changes(Total Drugs:1)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D003876	12/13/2001	elidel	pimecrolimus	Treatment of mild/moderate atopic dermatitis	Indicated for short-term and intermittent long-term therapy for mild to moderate atopic dermatitis in non-immunocompromised patients 2 years and older Not recommended for use in pediatric patients less than 2 years of age. Infants on Elidel Cream had an increased incidence of some adverse events compared to vehicle which included pyrexia, URI, nasopharyngitis, gastroenteritis, otitis media, and diarrhea.	Labeling	B	-	-	-	Novartis	09/24/2001	FALSE'