PedAM

Pediatric Disease Annotations & Medicines


	dental caries

Disease ID	494
Disease	dental caries
Definition	Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.
Synonym	caries caries dent caries dental caries, dental cariosity of teeth carious lesion carious teeth cavities cavity decay dent decay dental decay tooth decay, dental decayed teeth decaying tooth decays tooth dent caries dent decay dental caries (disorder) dental caries [disease/finding] dental caries nos dental caries nos (disorder) dental caries, nos dental caries, unspecified dental cavities dental cavity dental cavity, nos dental decay early dental caries frequent caries saprodontia teeth decayed tooth caries tooth cavities tooth cavity tooth decay tooth decayed
DOID	DOID:216
ICD10	ICD10CM:K02.9
UMLS	C0011334
MeSH	D003731
SNOMED-CT	SNOMEDCT_US_2016_09_01:80967001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:51) C0011849 \| diabetes mellitus \| 6 C0011847 \| diabetes \| 6 C0008924 \| cleft lip \| 5 C0004623 \| bacterial infection \| 4 C0011334 \| caries \| 4 C0028754 \| obesity \| 3 C0011854 \| type 1 diabetes mellitus \| 3 C0007789 \| cerebral palsy \| 3 C0011854 \| type 1 diabetes \| 3 C0003467 \| anxiety \| 2 C0028754 \| adiposity \| 2 C0034103 \| pulpitis \| 2 C0011407 \| necrotic pulp \| 2 C0026636 \| oral disease \| 2 C0011860 \| diabetes mellitus type 2 \| 2 C0031024 \| periapical abscess \| 2 C0011351 \| hypoplastic enamel \| 1 C0004096 \| asthma \| 1 C0011351 \| enamel hypoplasia \| 1 C0029443 \| osteomyelitis \| 1 C0031090 \| periodontal disease \| 1 C0004936 \| mental disorders \| 1 C0011570 \| depression \| 1 C0026618 \| dental fluorosis \| 1 C0035309 \| retinopathy \| 1 C0004623 \| bacterial infections \| 1 C0019069 \| hemophilia \| 1 C0011854 \| type i diabetes \| 1 C1263846 \| attention deficit hyperactivity disorder \| 1 C0018799 \| heart disease \| 1 C0018799 \| heart diseases \| 1 C0011854 \| type i diabetes mellitus \| 1 C0014118 \| endocarditis \| 1 C0085113 \| neurofibromatosis \| 1 C0162316 \| iron deficiency anaemia \| 1 C0010674 \| cystic fibrosis \| 1 C0003873 \| rheumatoid arthritis \| 1 C0011334 \| cavities \| 1 C0007570 \| celiac disease \| 1 C0004096 \| bronchial asthma \| 1 C0158646 \| cleft lip/palate \| 1 C0003864 \| arthritis \| 1 C0017574 \| gingivitis \| 1 C0001126 \| renal tubular acidosis \| 1 C0031099 \| periodontitis \| 1 C0162429 \| malnutrition \| 1 C0002871 \| anaemia \| 1 C0162429 \| poor nutrition \| 1 C0011884 \| diabetic retinopathy \| 1 C0032285 \| pneumonia \| 1 C0037199 \| sinusitis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:7) CDKN3 \| 1033 \| GWASCAT ABCG2 \| 9429 \| GWASCAT ATXN7L1 \| 222255 \| GWASCAT LYZL2 \| 119180 \| GWASCAT PROM1 \| 8842 \| GWASCAT RPS6KA2 \| 6196 \| GWASCAT ADAMTS3 \| 9508 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:14) 258 \| AMBN \| infer 265 \| AMELX \| infer 10117 \| ENAM \| infer 346562 \| GNAT3 \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 4057 \| LTF \| infer 4153 \| MBL2 \| infer 744 \| MPPED2 \| infer 9110 \| MTMR4 \| infer 80834 \| TAS1R2 \| infer 5726 \| TAS2R38 \| infer 24144 \| TFIP11 \| infer 7286 \| TUFT1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:279) 50865 \| HEBP1 \| DISEASES 266 \| AMELY \| DISEASES 9524 \| TECR \| DISEASES 129138 \| ANKRD54 \| DISEASES 9567 \| GTPBP1 \| DISEASES 158 \| ADSL \| DISEASES 1472 \| CST4 \| DISEASES 63035 \| BCORL1 \| DISEASES 4313 \| MMP2 \| DISEASES 79650 \| USB1 \| DISEASES 10423 \| CDIPT \| DISEASES 10404 \| CPQ \| DISEASES 973 \| CD79A \| DISEASES 3036 \| HAS1 \| DISEASES 2597 \| GAPDH \| DISEASES 80736 \| SLC44A4 \| DISEASES 3111 \| HLA-DOA \| DISEASES 9450 \| LY86 \| DISEASES 3003 \| GZMK \| DISEASES 4057 \| LTF \| DISEASES 566 \| AZU1 \| DISEASES 4317 \| MMP8 \| DISEASES 3624 \| INHBA \| DISEASES 5552 \| SRGN \| DISEASES 5184 \| PEPD \| DISEASES 8192 \| CLPP \| DISEASES 11034 \| DSTN \| DISEASES 6779 \| STATH \| DISEASES 3346 \| HTN1 \| DISEASES 1315 \| COPB1 \| DISEASES 3630 \| INS \| DISEASES 9119 \| KRT75 \| DISEASES 3270 \| HRC \| DISEASES 83854 \| ANGPTL6 \| DISEASES 140683 \| BPIFA2 \| DISEASES 759 \| CA1 \| DISEASES 83998 \| REG4 \| DISEASES 10542 \| LAMTOR5 \| DISEASES 10468 \| FST \| DISEASES 4677 \| NARS \| DISEASES 10220 \| GDF11 \| DISEASES 80326 \| WNT10A \| DISEASES 3569 \| IL6 \| DISEASES 10241 \| CALCOCO2 \| DISEASES 7097 \| TLR2 \| DISEASES 9313 \| MMP20 \| DISEASES 23314 \| SATB2 \| DISEASES 4069 \| LYZ \| DISEASES 11019 \| LIAS \| DISEASES 3839 \| KPNA3 \| DISEASES 114294 \| LACTB \| DISEASES 23531 \| MMD \| DISEASES 57045 \| TWSG1 \| DISEASES 4025 \| LPO \| DISEASES 25939 \| SAMHD1 \| DISEASES 3553 \| IL1B \| DISEASES 8726 \| EED \| DISEASES 9424 \| KCNK6 \| DISEASES 9855 \| FARP2 \| DISEASES 8452 \| CUL3 \| DISEASES 2255 \| FGF10 \| DISEASES 80321 \| CEP70 \| DISEASES 51726 \| DNAJB11 \| DISEASES 10312 \| TCIRG1 \| DISEASES 6595 \| SMARCA2 \| DISEASES 55749 \| CCAR1 \| DISEASES 347902 \| AMIGO2 \| DISEASES 11081 \| KERA \| DISEASES 2252 \| FGF7 \| DISEASES 6455 \| SH3GL1 \| DISEASES 1513 \| CTSK \| DISEASES 10637 \| LEFTY1 \| DISEASES 10217 \| CTDSPL \| DISEASES 10769 \| PLK2 \| DISEASES 740 \| MRPL49 \| DISEASES 26040 \| SETBP1 \| DISEASES 1834 \| DSPP \| DISEASES 118611 \| C10orf90 \| DISEASES 56934 \| CA10 \| DISEASES 760 \| CA2 \| DISEASES 761 \| CA3 \| DISEASES 245972 \| ATP6V0D2 \| DISEASES 9337 \| CNOT8 \| DISEASES 90525 \| SHF \| DISEASES 2220 \| FCN2 \| DISEASES 221914 \| GPC2 \| DISEASES 121214 \| SDR9C7 \| DISEASES 362 \| AQP5 \| DISEASES 10158 \| PDZK1IP1 \| DISEASES 248 \| ALPI \| DISEASES 152185 \| SPICE1 \| DISEASES 213 \| ALB \| DISEASES 25976 \| TIPARP \| DISEASES 8927 \| BSN \| DISEASES 4724 \| NDUFS4 \| DISEASES 6862 \| T \| DISEASES 1278 \| COL1A2 \| DISEASES 1672 \| DEFB1 \| DISEASES 219793 \| TBATA \| DISEASES 79158 \| GNPTAB \| DISEASES 124872 \| B4GALNT2 \| DISEASES 6240 \| RRM1 \| DISEASES 10653 \| SPINT2 \| DISEASES 4589 \| MUC7 \| DISEASES 121340 \| SP7 \| DISEASES 10296 \| MAEA \| DISEASES 53342 \| IL17D \| DISEASES 140738 \| TMEM37 \| DISEASES 51181 \| DCXR \| DISEASES 1673 \| DEFB4A \| DISEASES 260434 \| PYDC1 \| DISEASES 10421 \| CD2BP2 \| DISEASES 9655 \| SOCS5 \| DISEASES 649 \| BMP1 \| DISEASES 1469 \| CST1 \| DISEASES 54910 \| SEMA4C \| DISEASES 3799 \| KIF5B \| DISEASES 1473 \| CST5 \| DISEASES 5162 \| PDHB \| DISEASES 763 \| CA5A \| DISEASES 392 \| ARHGAP1 \| DISEASES 56945 \| MRPS22 \| DISEASES 8567 \| MADD \| DISEASES 92745 \| SLC38A5 \| DISEASES 258 \| AMBN \| DISEASES 57101 \| ANO2 \| DISEASES 810 \| CALML3 \| DISEASES 23541 \| SEC14L2 \| DISEASES 53347 \| UBASH3A \| DISEASES 8685 \| MARCO \| DISEASES 2193 \| FARSA \| DISEASES 8727 \| CTNNAL1 \| DISEASES 414325 \| DEFB103A \| DISEASES 23017 \| FAIM2 \| DISEASES 64840 \| PORCN \| DISEASES 81618 \| ITM2C \| DISEASES 10160 \| FARP1 \| DISEASES 6514 \| SLC2A2 \| DISEASES 8100 \| IFT88 \| DISEASES 7706 \| TRIM25 \| DISEASES 55894 \| DEFB103B \| DISEASES 9622 \| KLK4 \| DISEASES 79228 \| THOC6 \| DISEASES 2187 \| FANCB \| DISEASES 286753 \| TUSC5 \| DISEASES 277 \| AMY1B \| DISEASES 9988 \| DMTF1 \| DISEASES 23762 \| OSBP2 \| DISEASES 5104 \| SERPINA5 \| DISEASES 3840 \| KPNA4 \| DISEASES 128178 \| EDARADD \| DISEASES 64386 \| MMP25 \| DISEASES 6622 \| SNCA \| DISEASES 3329 \| HSPD1 \| DISEASES 1447 \| CSN2 \| DISEASES 113675 \| SDSL \| DISEASES 54681 \| P4HTM \| DISEASES 132660 \| LIN54 \| DISEASES 6633 \| SNRPD2 \| DISEASES 159296 \| NKX2-3 \| DISEASES 5348 \| FXYD1 \| DISEASES 83756 \| TAS1R3 \| DISEASES 199953 \| TMEM201 \| DISEASES 766 \| CA7 \| DISEASES 79971 \| WLS \| DISEASES 133584 \| EGFLAM \| DISEASES 146059 \| CDAN1 \| DISEASES 6597 \| SMARCA4 \| DISEASES 54879 \| ST7L \| DISEASES 744 \| MPPED2 \| DISEASES 871 \| SERPINH1 \| DISEASES 4763 \| NF1 \| DISEASES 5792 \| PTPRF \| DISEASES 79947 \| DHDDS \| DISEASES 11169 \| WDHD1 \| DISEASES 140803 \| TRPM6 \| DISEASES 10367 \| MICU1 \| DISEASES 11214 \| AKAP13 \| DISEASES 4514 \| MT-CO3 \| DISEASES 56259 \| CTNNBL1 \| DISEASES 54617 \| INO80 \| DISEASES 88 \| ACTN2 \| DISEASES 58480 \| RHOU \| DISEASES 3664 \| IRF6 \| DISEASES 722 \| C4BPA \| DISEASES 2494 \| NR5A2 \| DISEASES 10090 \| UST \| DISEASES 5451 \| POU2F1 \| DISEASES 6675 \| UAP1 \| DISEASES 9191 \| DEDD \| DISEASES 7286 \| TUFT1 \| DISEASES 1755 \| DMBT1 \| DISEASES 1520 \| CTSS \| DISEASES 51177 \| PLEKHO1 \| DISEASES 2045 \| EPHA7 \| DISEASES 8732 \| RNGTT \| DISEASES 2316 \| FLNA \| DISEASES 278 \| AMY1C \| DISEASES 276 \| AMY1A \| DISEASES 4534 \| MTM1 \| DISEASES 55788 \| LMBRD1 \| DISEASES 959 \| CD40LG \| DISEASES 4318 \| MMP9 \| DISEASES 5631 \| PRPS1 \| DISEASES 10269 \| ZMPSTE24 \| DISEASES 27286 \| SRPX2 \| DISEASES 5453 \| POU3F1 \| DISEASES 5464 \| PPA1 \| DISEASES 113452 \| TMEM54 \| DISEASES 7099 \| TLR4 \| DISEASES 56288 \| PARD3 \| DISEASES 249 \| ALPL \| DISEASES 229 \| ALDOB \| DISEASES 119180 \| LYZL2 \| DISEASES 80834 \| TAS1R2 \| DISEASES 8874 \| ARHGEF7 \| DISEASES 23013 \| SPEN \| DISEASES 1041 \| CDSN \| DISEASES 256297 \| PTF1A \| DISEASES 765 \| CA6 \| DISEASES 8573 \| CASK \| DISEASES 55966 \| AJAP1 \| DISEASES 54880 \| BCOR \| DISEASES 54363 \| HAO1 \| DISEASES 79625 \| NDNF \| DISEASES 5160 \| PDHA1 \| DISEASES 833 \| CARS \| DISEASES 265 \| AMELX \| DISEASES 2103 \| ESRRB \| DISEASES 414 \| ARSD \| DISEASES 2813 \| GP2 \| DISEASES 140809 \| SRXN1 \| DISEASES 1667 \| DEFA1 \| DISEASES 728358 \| DEFA1B \| DISEASES 2235 \| FECH \| DISEASES 10675 \| CSPG5 \| DISEASES 4291 \| MLF1 \| DISEASES 5450 \| POU2AF1 \| DISEASES 51520 \| LARS \| DISEASES 10117 \| ENAM \| DISEASES 4668 \| NAGA \| DISEASES 594857 \| NPS \| DISEASES 346562 \| GNAT3 \| DISEASES 1837 \| DTNA \| DISEASES 6345 \| SRL \| DISEASES 10747 \| MASP2 \| DISEASES 24144 \| TFIP11 \| DISEASES 6611 \| SMS \| DISEASES 1747 \| DLX3 \| DISEASES 51005 \| AMDHD2 \| DISEASES 23210 \| JMJD6 \| DISEASES 25801 \| GCA \| DISEASES 283463 \| MUC19 \| DISEASES 7124 \| TNF \| DISEASES 2821 \| GPI \| DISEASES 51071 \| DERA \| DISEASES 374308 \| PTCHD3 \| DISEASES 10772 \| SRSF10 \| DISEASES 127933 \| UHMK1 \| DISEASES 80012 \| PHC3 \| DISEASES 158835 \| AWAT2 \| DISEASES 7511 \| XPNPEP1 \| DISEASES 6949 \| TCOF1 \| DISEASES 221823 \| PRPS1L1 \| DISEASES 100289462 \| DEFB4B \| DISEASES 6196 \| RPS6KA2 \| DISEASES 253970 \| SFTA3 \| DISEASES 3347 \| HTN3 \| DISEASES 727897 \| MUC5B \| DISEASES 3250 \| HPR \| DISEASES 8725 \| URI1 \| DISEASES 7421 \| VDR \| DISEASES 8972 \| MGAM \| DISEASES 5726 \| TAS2R38 \| DISEASES 2972 \| BRF1 \| DISEASES 820 \| CAMP \| DISEASES 104355217 \| ERICD \| DISEASES 100126781 \| SNAR-F \| DISEASES 692233 \| SNORD117 \| DISEASES
Locus	(Waiting for update.)

Disease ID	494
Disease	dental caries
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:40) HP:0012531 \| Pain \| 12 HP:0000819 \| Diabetes mellitus \| 6 HP:0000670 \| Dental caries \| 5 HP:0000217 \| Dry mouth syndrome \| 5 HP:0000689 \| Misalignment of upper and lower dental arches \| 4 HP:0001513 \| Obesity \| 3 HP:0100021 \| Cerebral palsy \| 3 HP:0030757 \| Dental abscess \| 2 HP:0006349 \| Agenesis of permanent dentition \| 2 HP:0000739 \| Anxiety \| 2 HP:0002099 \| Asthma \| 2 HP:0006297 \| Hypoplasia of tooth enamel \| 1 HP:0002754 \| Bone infection \| 1 HP:0100812 \| bad breath \| 1 HP:0001695 \| Cardiac arrest \| 1 HP:0000716 \| Depression \| 1 HP:0012532 \| Chronic pain \| 1 HP:0100806 \| Sepsis \| 1 HP:0000230 \| Inflamed gums \| 1 HP:0001947 \| Renal tubular acidosis \| 1 HP:0000752 \| Hyperactive behavior \| 1 HP:0007018 \| Attention deficits \| 1 HP:0100584 \| Endocarditis \| 1 HP:0006699 \| Ectopic supraventricular rhythms \| 1 HP:0001548 \| Overgrowth \| 1 HP:0000704 \| Pyorrhea \| 1 HP:0001067 \| Neurofibromas \| 1 HP:0002013 \| Emesis \| 1 HP:0001520 \| Birthweight > 90th percentile \| 1 HP:0100651 \| Type I diabetes mellitus \| 1 HP:0001369 \| Arthritis \| 1 HP:0004395 \| Malnutrition \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0000246 \| Sinus inflammation \| 1 HP:0001903 \| Anemia \| 1 HP:0002090 \| Pneumonia \| 1 HP:0002608 \| Celiac disease \| 1 HP:0000700 \| Periapical radiolucency \| 1 HP:0000211 \| Trismus \| 1 HP:0000488 \| Noninflammatory retina disease \| 1

Disease ID	494
Disease	dental caries
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0030193 \| pain \| 12 C0080233 \| tooth loss \| 9

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:14)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10242311	23064961	222255	ATXN7L1	umls:C0011334	GWASCAT	GWAS of dental caries patterns in the permanent dentition.	0.12	2013	ATXN7L1	7	105633273	A	C
rs11031093	21940522	744	MPPED2	umls:C0011334	GAD	[No associations met strict criteria for genome-wide significance (p < 10E-7); however, several loci (ACTN2, MTR, and EDARADD, MPPED2, and LPO) with plausible biological roles in dental caries exhibited suggestive evidence for association.]	0.002638474	2011	MPPED2	11	30445953	G	A
rs1383934	23259602	9508	ADAMTS3	umls:C0011334	GWASCAT	Genome-wide association scan of dental caries in the permanent dentition.	0.12	2012	ADAMTS3	4	72551807	G	A
rs2232387	25347471	9119	KRT75	umls:C0011334	BeFree	Using genetic and intraoral examination data from 386 children and 706 adults, we found that individuals harboring known hair disorder-associated polymorphisms in the gene encoding keratin 75 (KRT75), KRT75(A161T) and KRT75(E337K), are prone to increased dental caries.	0.000271442	2014	KRT75	12	52433824	C	T
rs2232398	25347471	9119	KRT75	umls:C0011334	BeFree	Using genetic and intraoral examination data from 386 children and 706 adults, we found that individuals harboring known hair disorder-associated polymorphisms in the gene encoding keratin 75 (KRT75), KRT75(A161T) and KRT75(E337K), are prone to increased dental caries.	0.000271442	2014	KRT75	12	52430567	C	T
rs2302189	21940522	9110	MTMR4	umls:C0011334	GAD	[Genome-wide association scan for childhood caries implicates novel genes.]	0.002367032	2011	MTMR4	17	58506844	A	C
rs2337359	25373699	7286	TUFT1	umls:C0011334	BeFree	We observed the statistically significant association of rs2337359 upstream of TUFT1 with dental caries experience via meta-analysis across adult samples (p < 0.002) and the suggestive association for multiple variants in TFIP11 across child samples (p < 0.05).	0.003181358	2014	CGN	1	151523320	T	C
rs2337359	25373699	24144	TFIP11	umls:C0011334	BeFree	We observed the statistically significant association of rs2337359 upstream of TUFT1 with dental caries experience via meta-analysis across adult samples (p < 0.002) and the suggestive association for multiple variants in TFIP11 across child samples (p < 0.05).	0.002909916	2014	CGN	1	151523320	T	C
rs2531154	23064961	8842	PROM1	umls:C0011334	GWASCAT	GWAS of dental caries patterns in the permanent dentition.	0.12	2013	PROM1	4	16016701	C	T
rs3114018	23064961	9429	ABCG2	umls:C0011334	GWASCAT	GWAS of dental caries patterns in the permanent dentition.	0.12	2013	ABCG2	4	88143429	A	C
rs399593	23064961	119180	LYZL2	umls:C0011334	GWASCAT	We identified a significant genetic association between dental caries of the anterior mandibular teeth and LYZL2 (p value = 9e-9), which codes a bacteriolytic agent thought to be involved in host defense.	0.120542884	2013	LYZL2	10	30623101	G	T
rs4251631	23259602	1033	CDKN3	umls:C0011334	GWASCAT	Genome-wide association scan of dental caries in the permanent dentition.	0.12	2012	CDKN3	14	54409466	T	C
rs545610	21940522	744	MPPED2	umls:C0011334	GAD	[No associations met strict criteria for genome-wide significance (p < 10E-7); however, several loci (ACTN2, MTR, and EDARADD, MPPED2, and LPO) with plausible biological roles in dental caries exhibited suggestive evidence for association.]	0.002638474	2011	MPPED2	11	30486561	T	C
rs635808	23259602	6196	RPS6KA2	umls:C0011334	GWASCAT	In general, we identified several suggestive loci (P-value ≤ 10E-05) within or near genes with plausible biological roles for dental caries, including RPS6KA2 and PTK2B, involved in p38-depenedent MAPK signaling, and RHOU and FZD1, involved in the Wnt signaling cascade.	0.12	2012	RPS6KA2	6	166763934	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:242)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	4559901	rs4654438	T	C	rs4654438	24556642	2.00E-06	(dfsSM)	1.63	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs4654438-T	Research Support, N.I.H., Extramural	T	NA
1	4560405	rs9660574	G	A	rs9660574	24556642	3.22E-06	(dfsSM)	1.56	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs9660574-A	Research Support, N.I.H., Extramural	G	NA
1	4562476	rs4654548	G	A	rs4654548	24556642	4.09E-06	(dfsSM)	1.54	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs4654548-A	Research Support, N.I.H., Extramural	A	NA
1	4565906	rs10753381	C	T	rs10753381	24556642	1.76E-06	(dfsSM)	1.6	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs10753381-T	Research Support, N.I.H., Extramural	C	NA
1	4668670	rs3896439	G	A	rs3896439	23064961	2.00E-08	DMFS5max, DMFS5	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	C	NA
1	9432390	rs9308447	C	T	rs9308447	23064961	5.00E-07	DMFS5mand	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	T	NA
1	60373775	rs1155002	T	C	rs1155002	21940522	1.11E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
1	85226299	rs1750491	T	C	rs1750491	23064961	2.00E-06	LPAR3	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	G	NA
1	99348836	rs11166135	A	G	rs11166135	23064961	1.00E-06	DMFS3	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	A	NA
1	99386293	rs1571500	T	C	rs1571500	23259602	2.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	T	LPPR5
1	168608152	rs7551639	G	A	rs7551639	21940522	2.20E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
1	204784018	rs7552806	A	C	rs7552806	23064961	3.00E-06	DMFS5, DMFS5max	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	A	NA
1	204784018	rs7552806	A	C	rs7552806	23064961	3.00E-06	DMFS5,DMFS5max	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	A	NA
1	210898263	rs1934620	A	G	rs1934620	23470693	8.00E-06	NA	4.25	[NA] unit increase	982 European ancestry individuals	European(982)	ALL(982)	EUR(982)	ALL(982)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs1934620-A	Research Support, N.I.H., Extramural	Comparative Study	A
1	218931905	rs12037343	G	T	rs12037343	24556642	3.00E-06	(dfsSM)	2.22	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs12037343-T	Research Support, N.I.H., Extramural	G	NA
1	218934929	rs17048517	C	A	rs17048517	24556642	2.95E-06	(dfsSM)	2.24	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17048517-A	Research Support, N.I.H., Extramural	C	NA
1	218992800	rs12033283	G	A	rs12033283	24556642	7.42E-06	(dfsSM)	1.85	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs12033283-A	Research Support, N.I.H., Extramural	G	NA
1	229285858	rs9793739	G	A	rs9793739	23259602	4.00E-06	NA	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	G	NA
1	229285858	rs9793739	G	A	rs9793739	23259602	5.00E-07	Comparatively Older	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	G	NA
1	232756026	rs10495332	T	C	rs10495332	24556642	8.00E-06	(dfsSM)	4.12	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs10495332-T	Research Support, N.I.H., Extramural	T	NA
1	236803753	rs10925178	G	A	rs10925178	21940522	3.83E-05	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
1	236817010	rs10925185	T	C	rs10925185	21940522	1.89E-05	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
1	237069315	rs11806016	C	T	rs11806016	21940522	3.87E-06	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
2	12968900	rs10180496	A	G	rs10180496	23064961	1.00E-07	DMFS5, DMFS5mand	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	A	NA
2	55688713	rs4671246	C	T	rs4671246	21940522	1.96E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
2	133313845	rs9287421	C	T	rs9287421	21940522	1.69E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
2	144093331	rs12691674	T	C	rs12691674	24556642	2.23E-06	(dfsSM)	1.75	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs12691674-T	Research Support, N.I.H., Extramural	T	ARHGAP15
2	144095037	rs17229397	T	A	rs17229397	24556642	1.97E-06	(dfsSM)	1.76	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17229397-A	Research Support, N.I.H., Extramural	T	ARHGAP15
2	144096374	rs10176394	T	C	rs10176394	24556642	2.00E-06	(dfsSM)	1.77	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs10176394-T	Research Support, N.I.H., Extramural	T	ARHGAP15
2	144102594	rs10496946	C	T	rs10496946	24556642	2.01E-06	(dfsSM)	1.66	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs10496946-A	Research Support, N.I.H., Extramural	G	ARHGAP15
2	144102594	rs532311971	CAAT	C	rs10496946	24556642	2.01E-06	(dfsSM)	1.66	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs10496946-A	Research Support, N.I.H., Extramural	G	ARHGAP15
2	144102594	rs562827965	CAAT	C	rs10496946	24556642	2.01E-06	(dfsSM)	1.66	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs10496946-A	Research Support, N.I.H., Extramural	G	ARHGAP15
2	167177359	rs4438497	T	C	rs4438497	23259602	7.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	T	SCN9A
2	219130514	rs1079204	G	A	rs1079204	23470693	2.00E-06	NA	8.45	[NA] unit increase	982 European ancestry individuals	European(982)	ALL(982)	EUR(982)	ALL(982)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs1079204-A	Research Support, N.I.H., Extramural	Comparative Study	G
2	240055553	rs2121980	T	C	rs2121980	21940522	7.10E-05	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
3	2423127	rs17013524	T	G	rs17013524	24556642	8.59E-06	(dfsPF)	1.83	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17013524-T	Research Support, N.I.H., Extramural	T	CNTN4
3	28964801	rs4016429	C	G	rs4016429	24556642	2.00E-06	(dfsSM)	4.56	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs4016429-C	Research Support, N.I.H., Extramural	C	NA
3	30372053	rs7634533	C	A	rs7634533	23259602	5.00E-06	NA	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	C	NA
3	60001825	rs9311745	T	C	rs9311745	23470693	5.00E-06	NA	2.99	[NA] unit increase	996 European ancestry individuals	European(996)	ALL(996)	EUR(996)	ALL(996)	Pit-and-Fissure caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs9311745-C	Research Support, N.I.H., Extramural	Comparative Study	T
3	87618918	rs2048291	A	C	rs2048291	21940522	3.48E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
3	112995074	rs775227	A	C	rs775227	23259602	2.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	A	BOC
3	113290468	rs13092825	T	C	rs13092825	23259602	2.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	T	SIDT1
3	113890789	rs3732783	T	C	rs3732783	24556642	9.00E-06	(dfsSM)	1.88	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs3732783-T	Research Support, N.I.H., Extramural	G	DRD3
3	128282697	rs6806253	A	G	rs6806253	23470693	6.00E-06	NA	1.56	[NA] unit decrease	996 European ancestry individuals	European(996)	ALL(996)	EUR(996)	ALL(996)	Pit-and-Fissure caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs6806253-A	Research Support, N.I.H., Extramural	Comparative Study	A
3	128652553	rs9810890	C	T	rs9810890	23064961	6.00E-06	DMFS2	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	C	LOC100132731
3	136476862	rs6789329	T	C	rs6789329	21940522	3.48E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T,C
3	142412224	rs1916638	C	T	rs1916638	21940522	3.28E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C,T
3	160226307	rs17236529	C	T	rs17236529	24556642	2.03E-09	(dfsPF)	1.78	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17236529-T	Research Support, N.I.H., Extramural	C	KPNA4
3	160226307	rs17236529	C	T	rs17236529	24556642	3.00E-06	(dfsSM)	1.51	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17236529-T	Research Support, N.I.H., Extramural	C	KPNA4
3	160275031	rs17236537	G	A	rs17236537	24556642	1.70E-08	(dfsPF)	1.63	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17236537-A	Research Support, N.I.H., Extramural	G	KPNA4
3	160275031	rs17236537	G	A	rs17236537	24556642	3.52E-06	(dfsSM)	1.39	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17236537-A	Research Support, N.I.H., Extramural	G	KPNA4
4	16018324	rs2531154	C	T	rs2531154	23064961	9.00E-07	DMFS5max	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	A	PROM1
4	16022540	rs2677780	G	A	rs2677780	23470693	2.00E-06	NA	6.35	[NA] unit decrease	982 European ancestry individuals	European(982)	ALL(982)	EUR(982)	ALL(982)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs2677780-A	Research Support, N.I.H., Extramural	Comparative Study	T
4	40973527	rs4466078	T	A	rs4466078	23259602	8.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	A	APBB2
4	73417524	rs1383934	G	A	rs1383934	23259602	2.00E-06	Comparatively Older	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	C	ADAMTS3
4	73417524	rs1383934	G	A	rs1383934	23259602	3.00E-07	NA	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	C	ADAMTS3
4	73970464	rs6818964	C	T	rs6818964	24556642	7.00E-07	(dfsSM)	5.63	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs6818964-T	Research Support, N.I.H., Extramural	C	ANKRD17
4	89064581	rs3114018	A	C	rs3114018	23064961	7.00E-08	DMFS5mand,DMFS5	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	A	ABCG2
4	146875551	rs723794	G	T	rs723794	23470693	6.00E-07	NA	3.65	[NA] unit increase	982 European ancestry individuals	European(982)	ALL(982)	EUR(982)	ALL(982)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs723794-G	Research Support, N.I.H., Extramural	Comparative Study	G
4	146904304	rs11100904	C	T	rs11100904	23064961	2.00E-06	DMFS3	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	C	NA
4	148282342	rs1429138	T	C	rs1429138	23064961	2.00E-07	DMFS2,DMFS5mand	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	C	NA
5	18733182	rs16886683	T	G	rs16886683	21940522	7.87E-05	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
5	50928810	rs4865673	G	A	rs4865673	23259602	9.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	G	NA
5	58071799	rs963443	A	G	rs963443	21940522	3.30E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
5	170240423	rs11134654	A	C	rs11134654	23470693	2.00E-07	NA	4.61	[NA] unit increase	982 European ancestry individuals	European(982)	ALL(982)	EUR(982)	ALL(982)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs11134654-A	Research Support, N.I.H., Extramural	Comparative Study	C
6	566741	rs2476842	A	G	rs2476842	23064961	3.00E-06	DMFS3	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	T	EXOC2
6	577820	rs9504361	A	G	rs9504361	23470693	6.00E-06	NA	1.16	[NA] unit increase	996 European ancestry individuals	European(996)	ALL(996)	EUR(996)	ALL(996)	Pit-and-Fissure caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs9504361-G	Research Support, N.I.H., Extramural	Comparative Study	A
6	3944424	rs4959901	C	T	rs4959901	21940522	2.36E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
6	11264612	rs6932615	T	G	rs6932615	21940522	2.07E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
6	39304211	rs3734621	A	C	rs3734621	24556642	1.04E-06	(dfsSM)	5.35	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs3734621-A	Research Support, N.I.H., Extramural	A	KIF6
6	39307032	rs9471075	A	C	rs9471075	24556642	1.00E-06	(dfsSM)	5.25	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs9471075-A	Research Support, N.I.H., Extramural	C	KIF6
6	39307032	rs9471075	A	C	rs9471075	24556642	9.71E-07	(dfsSM)	5.25	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs9471075-A	Research Support, N.I.H., Extramural	C	KIF6
6	116543847	rs1204798	A	G	rs1204798	23064961	2.00E-06	DMFS2	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	A	NT5DC1
6	134720067	rs9402592	G	A	rs9402592	23259602	3.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	A	NA
6	143070505	rs197480	C	T	rs197480	24556642	4.43E-06	(dfsPF)	1.43	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs197480-T	Research Support, N.I.H., Extramural	C	NA
6	167177422	rs635808	G	A	rs635808	23259602	1.00E-07	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	C	RPS6KA2
6	167363473	rs3798305	C	T	rs3798305	24556642	7.00E-06	(dfsSM)	4.83	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs3798305-T	Research Support, N.I.H., Extramural	C	RNASET2
7	7313294	rs6973768	T	G	rs6973768	24556642	7.43E-06	(dfsSM)	2.4	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs6973768-T	Research Support, N.I.H., Extramural	T	NA
7	7313485	rs6953213	G	A	rs6953213	24556642	6.00E-06	(dfsSM)	2.43	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs6953213-A	Research Support, N.I.H., Extramural	G	NA
7	7779324	rs10486187	T	C	rs10486187	24556642	4.99E-06	(dfsSM)	1.89	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs10486187-T	Research Support, N.I.H., Extramural	T	LOC729852
7	7779324	rs10486187	T	C	rs10486187	24556642	5.00E-06	(dfsSM)	1.89	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs10486187-T	Research Support, N.I.H., Extramural	T	LOC729852
7	20791998	rs2108258	A	G	rs2108258	23259602	2.00E-06	Comparatively Older	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	T	ABCB5
7	32444435	rs215738	G	A	rs215738	24556642	7.81E-06	(dfsSM)	3.78	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs215738-A	Research Support, N.I.H., Extramural	G	NA
7	32444435	rs215738	G	A	rs215738	24556642	8.00E-06	(dfsSM)	3.78	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs215738-A	Research Support, N.I.H., Extramural	G	NA
7	33181238	rs17169807	T	C	rs17169807	24556642	4.00E-06	(dfsSM)	2.55	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17169807-T	Research Support, N.I.H., Extramural	T	BBS9
7	41811908	rs10486722	C	T	rs10486722	23470693	7.00E-06	NA	1.22	[NA] unit increase	996 European ancestry individuals	European(996)	ALL(996)	EUR(996)	ALL(996)	Pit-and-Fissure caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs10486722-C	Research Support, N.I.H., Extramural	Comparative Study	T
7	53920963	rs6963388	G	A	rs6963388	24556642	5.35E-06	(dfsPF)	0.83	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs6963388-A	Research Support, N.I.H., Extramural	G	NA
7	53950851	rs1569247	T	C	rs1569247	24556642	6.52E-06	(dfsPF)	0.93	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs1569247-T	Research Support, N.I.H., Extramural	C	NA
7	53960934	rs12539883	C	T	rs12539883	24556642	5.46E-06	(dfsPF)	0.83	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs12539883-T	Research Support, N.I.H., Extramural	T	NA
7	53982626	rs17736906	A	G	rs17736906	24556642	2.46E-06	(dfsPF)	0.74	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17736906-A	Research Support, N.I.H., Extramural	A	NA
7	54034670	rs6956800	T	C	rs6956800	24556642	8.24E-06	(dfsPF)	0.88	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs6956800-T	Research Support, N.I.H., Extramural	T	NA
7	54034751	rs6971084	C	T	rs6971084	24556642	8.43E-06	(dfsPF)	1.09	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs6971084-T	Research Support, N.I.H., Extramural	C	NA
7	54044068	rs7785867	G	A	rs7785867	24556642	2.88E-06	(dfsPF)	1.04	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs7785867-A	Research Support, N.I.H., Extramural	G	NA
7	54048025	rs7789754	A	G	rs7789754	24556642	9.86E-06	(dfsPF)	1.09	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs7789754-A	Research Support, N.I.H., Extramural	A	NA
7	57584913	rs4870622	A	G	rs4870622	21940522	2.98E-05	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
7	77596812	rs848452	T	C	rs848452	23064961	2.00E-06	DMFS2	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	C	NA
7	89060733	rs6973392	C	T	rs6973392	23259602	7.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	T	NA
7	90915354	rs2888830	G	A	rs2888830	23259602	4.00E-06	NA	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	A	NA
7	90915354	rs2888830	G	A	rs2888830	23259602	7.00E-06	Comparatively Older	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	A	NA
7	105273720	rs10242311	A	C	rs10242311	23064961	6.00E-07	DMFS5mand	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	A	ATXN7L1
7	140888321	rs16882396	C	G	rs16882396	24556642	2.00E-06	(dfsSM)	1.16	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs16882396-C	Research Support, N.I.H., Extramural	C	LOC100507421
8	19083152	rs17128007	C	T	rs17128007	24556642	7.00E-06	(dfsSM)	4.8	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17128007-T	Research Support, N.I.H., Extramural	C	LOC100128993
8	20301437	rs4922199	A	C	rs4922199	23259602	8.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	A	NA
8	20336573	rs10111661	G	A	rs10111661	23064961	2.00E-06	DMFS5max,DMFS5	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	G	NA
8	20565015	rs6992419	A	C	rs6992419	21940522	6.43E-06	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
8	20576761	rs13258625	T	C	rs13258625	21940522	1.91E-05	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
8	20580511	rs1530781	G	A	rs1530781	21940522	3.35E-05	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
8	27416801	rs17057381	G	A	rs17057381	23259602	4.00E-07	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	G	NA
8	58986459	rs13273891	G	A	rs13273891	24556642	1.95E-06	(dfsPF)	0.95	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs13273891-A	Research Support, N.I.H., Extramural	A	FAM110B
8	89993488	rs10429371	C	T	rs10429371	23470693	3.00E-06	NA	3.8	[NA] unit increase	982 European ancestry individuals	European(982)	ALL(982)	EUR(982)	ALL(982)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs10429371-C	Research Support, N.I.H., Extramural	Comparative Study	T
8	90211100	rs2046315	A	G	rs2046315	23259602	3.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	T	NA
8	90211100	rs2046315	A	G	rs2046315	23470693	7.00E-07	NA	1.87	[NA] unit increase	996 European ancestry individuals	European(996)	ALL(996)	EUR(996)	ALL(996)	Pit-and-Fissure caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs2046315-T	Research Support, N.I.H., Extramural	Comparative Study	T
8	90211100	rs2046315	A	G	rs2046315	23470693	8.00E-08	NA	5.19	[NA] unit increase	982 European ancestry individuals	European(982)	ALL(982)	EUR(982)	ALL(982)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs2046315-T	Research Support, N.I.H., Extramural	Comparative Study	T
8	102375267	rs16867579	A	C	rs16867579	24556642	1.00E-06	(dfsSM)	8.42	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs16867579-A	Research Support, N.I.H., Extramural	C	NA
8	104426045	rs3134292	C	A	rs3134292	21940522	1.49E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
8	104426245	rs3133817	A	G	rs3133817	21940522	1.42E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
8	107909009	rs4269515	A	G	rs4269515	23259602	4.00E-06	NA	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	A	NA
8	133034837	rs12542759	T	G	rs12542759	24556642	3.97E-06	(dfsPF)	0.8	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs12542759-T	Research Support, N.I.H., Extramural	T	NA
8	133035196	rs7007939	G	A	rs7007939	24556642	4.11E-06	(dfsPF)	0.81	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs7007939-A	Research Support, N.I.H., Extramural	G	NA
9	10275798	rs10958998	A	G	rs10958998	24556642	3.84E-06	(dfsPF)	1.19	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs10958998-A	Research Support, N.I.H., Extramural	G	PTPRD
9	71471912	rs6560397	C	T	rs6560397	23470693	2.00E-07	NA	1.29	[NA] unit decrease	996 European ancestry individuals	European(996)	ALL(996)	EUR(996)	ALL(996)	Pit-and-Fissure caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs6560397-T	Research Support, N.I.H., Extramural	Comparative Study	C
9	102234323	rs649057	C	A	rs649057	23064961	5.00E-06	DMFS5	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	T	NA
9	102234323	rs649057	C	A	rs649057	23470693	8.00E-06	NA	6.81	[NA] unit increase	982 European ancestry individuals	European(982)	ALL(982)	EUR(982)	ALL(982)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs649057-T	Research Support, N.I.H., Extramural	Comparative Study	T
9	129143435	rs2286889	A	G	rs2286889	21940522	7.19E-05	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
10	10073544	rs10905651	G	A	rs10905651	23259602	8.00E-06	Comparatively Older	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	A	NA
10	10601860	rs11256676	A	G	rs11256676	23064961	5.00E-06	DMFS5mand	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	A	NA
10	13796225	rs7095537	T	C	rs7095537	21940522	3.57E-06	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
10	30912030	rs399593	G	T	rs399593	23064961	9.00E-09	DMFS2	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	G	LYZL2
10	52013434	rs1865749	A	C	rs1865749	21940522	2.04E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
10	52019288	rs2574983	A	G	rs2574983	21940522	2.83E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
10	68165267	rs2441755	C	T	rs2441755	23064961	4.00E-06	DMFS5	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	T	CTNNA3
10	101274365	rs7078219	G	A	rs7078219	23064961	6.00E-06	DMFS5mand	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	A	NA
10	119193153	rs758569	C	A	rs758569	24556642	3.93E-06	(dfsPF)	0.8	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs758569-A	Research Support, N.I.H., Extramural	G	NA
10	119195881	rs2768336	A	G	rs2768336	24556642	6.54E-06	(dfsPF)	0.78	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs2768336-A	Research Support, N.I.H., Extramural	A	NA
11	6342329	rs1488864	T	G	rs1488864	24556642	1.00E-06	(dfsSM)	1.3	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs1488864-A	Research Support, N.I.H., Extramural	C	NA
11	6342329	rs1488864	T	G	rs1488864	24556642	1.02E-06	(dfsSM)	1.3	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs1488864-A	Research Support, N.I.H., Extramural	C	NA
11	6348614	rs4758096	C	G	rs4758096	24556642	9.65E-06	(dfsSM)	1.07	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs4758096-C	Research Support, N.I.H., Extramural	G	NA
11	6348639	rs4758408	T	C	rs4758408	24556642	1.12E-06	(dfsSM)	1.29	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs4758408-T	Research Support, N.I.H., Extramural	T	NA
11	30402105	rs487336	T	C	rs487336	21940522	9.39E-06	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
11	30435051	rs567056	G	T	rs567056	21940522	4.44E-06	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
11	30456545	rs980561	C	T	rs980561	21940522	4.14E-06	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
11	30456817	rs980562	G	A	rs980562	21940522	9.60E-07	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
11	30467500	rs11031093	G	A	rs11031093	21940522	8.00E-06	NA	1.36	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
11	30508108	rs545610	T	C	rs545610	21940522	9.00E-06	NA	1.34	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
11	30511665	rs10835673	A	C	rs10835673	24556642	8.15E-06	(dfsPF)	0.75	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs10835673-A	Research Support, N.I.H., Extramural	A	MPPED2
11	30512473	rs16920802	C	A	rs16920802	24556642	9.68E-06	(dfsPF)	0.74	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs16920802-A	Research Support, N.I.H., Extramural	C	MPPED2
11	30512726	rs12800941	T	A	rs12800941	24556642	9.07E-06	(dfsPF)	0.73	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs12800941-A	Research Support, N.I.H., Extramural	T	MPPED2
11	30520163	rs11031118	T	C	rs11031118	21940522	4.39E-06	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
11	30564577	rs7121800	T	C	rs7121800	24556642	6.85E-06	(dfsPF)	0.71	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs7121800-T	Research Support, N.I.H., Extramural	T	MPPED2
11	43064452	rs1425856	G	A	rs1425856	21940522	1.28E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
11	43077155	rs1425852	A	C	rs1425852	21940522	5.06E-05	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
11	81235150	rs2032381	G	T	rs2032381	23470693	4.00E-06	NA	5.69	[NA] unit decrease	982 European ancestry individuals	European(982)	ALL(982)	EUR(982)	ALL(982)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs2032381-G	Research Support, N.I.H., Extramural	Comparative Study	C
11	127451064	rs7109626	G	A	rs7109626	24556642	7.22E-06	(dfsPF)	1.72	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs7109626-A	Research Support, N.I.H., Extramural	G	NA
11	127460571	rs11822667	G	A	rs11822667	24556642	4.12E-06	(dfsPF)	1.66	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs11822667-A	Research Support, N.I.H., Extramural	G	NA
11	127480765	rs12295483	C	T	rs12295483	24556642	6.87E-06	(dfsPF)	1.6	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs12295483-T	Research Support, N.I.H., Extramural	C	NA
11	133120937	rs2078454	C	A	rs2078454	23470693	6.00E-06	NA	3.6	[NA] unit decrease	982 European ancestry individuals	European(982)	ALL(982)	EUR(982)	ALL(982)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs2078454-A	Research Support, N.I.H., Extramural	Comparative Study	C
12	27005960	rs7138744	A	G	rs7138744	24556642	3.00E-06	(dfsSM)	1.41	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs7138744-A	Research Support, N.I.H., Extramural	G	NA
12	32178900	rs7316376	G	A	rs7316376	21940522	2.48E-05	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
12	32194375	rs2594034	C	T	rs2594034	21940522	1.02E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
12	66633164	rs17826057	G	A	rs17826057	24556642	3.00E-07	(dfsSM)	2.65	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17826057-A	Research Support, N.I.H., Extramural	G	IRAK3
12	66633164	rs17826057	G	A	rs17826057	24556642	3.45E-07	(dfsSM)	2.65	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17826057-A	Research Support, N.I.H., Extramural	G	IRAK3
12	81337458	rs1163656	T	A,C,G	rs1163656	23259602	9.00E-06	Comparatively Older	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	T	NA
13	21280034	rs735539	A	G	rs735539	23064961	4.00E-06	DMFS2	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	T	IL17D
13	67696145	rs2875517	G	A	rs2875517	23064961	3.00E-06	DMFS3	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	A	PCDH9
13	98700617	rs16954776	A	G	rs16954776	24556642	9.00E-07	(dfsSM)	5.12	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs16954776-A	Research Support, N.I.H., Extramural	G	NA
13	98706911	rs7330185	C	T	rs7330185	24556642	8.73E-06	(dfsSM)	3.43	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs7330185-T	Research Support, N.I.H., Extramural	T	NA
13	98713169	rs7326592	G	A	rs7326592	24556642	8.37E-06	(dfsSM)	3.28	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs7326592-A	Research Support, N.I.H., Extramural	A	NA
13	98733003	rs17235905	A	G	rs17235905	24556642	8.60E-06	(dfsSM)	3.18	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17235905-A	Research Support, N.I.H., Extramural	A	NA
13	98733595	rs501660	C	T	rs501660	24556642	8.22E-06	(dfsSM)	3.21	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs501660-T	Research Support, N.I.H., Extramural	C	NA
13	98734952	rs285063	G	A	rs285063	24556642	2.56E-06	(dfsSM)	2.99	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs285063-A	Research Support, N.I.H., Extramural	A	NA
13	109502849	rs17485138	C	T	rs17485138	23064961	7.00E-06	DMFS2	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	C	MYO16
14	24951823	rs2076946	C	T	rs2076946	24556642	3.52E-06	(dfsSM)	0.03	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs2076946-A	Research Support, N.I.H., Extramural	A,G	NA
14	24954002	rs2877649	T	C	rs2877649	24556642	1.83E-06	(dfsSM)	0.19	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs2877649-T	Research Support, N.I.H., Extramural	T	NA
14	24954002	rs2877649	T	C	rs2877649	24556642	2.00E-06	(dfsSM)	0.19	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs2877649-T	Research Support, N.I.H., Extramural	T	NA
14	52884355	rs10143866	T	C	rs10143866	24556642	2.00E-06	(dfsSM)	1.47	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs10143866-T	Research Support, N.I.H., Extramural	C	NA
14	54652479	rs1953743	C	T	rs1953743	23259602	2.00E-06	Comparatively younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	C	NA
14	54876184	rs4251631	T	C	rs4251631	23259602	2.00E-06	NA	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	C	CDKN3
14	54876184	rs4251631	T	C	rs4251631	23259602	2.00E-07	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	C	CDKN3
14	81598912	rs17111530	T	C	rs17111530	24556642	1.00E-06	(dfsSM)	2.53	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17111530-T	Research Support, N.I.H., Extramural	T	TSHR
14	81598912	rs17111530	T	C	rs17111530	24556642	1.15E-06	(dfsSM)	2.53	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17111530-T	Research Support, N.I.H., Extramural	T	TSHR
14	81604362	rs11625193	T	C	rs11625193	24556642	2.02E-06	(dfsSM)	2.52	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs11625193-T	Research Support, N.I.H., Extramural	T	TSHR
14	87129218	rs1891547	C	T	rs1891547	21940522	5.39E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
14	100386584	rs11160559	A	G	rs11160559	21940522	5.51E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
15	27877061	rs7173054	C	A	rs7173054	21940522	2.61E-05	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
15	81651003	rs7178648	G	A	rs7178648	21940522	3.17E-05	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G,A
16	7929654	rs9788925	A	C	rs9788925	24556642	2.25E-06	(dfsPF)	1.02	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs9788925-A	Research Support, N.I.H., Extramural	A	NA
16	7929828	rs9788927	A	C	rs9788927	24556642	2.17E-06	(dfsPF)	1.02	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs9788927-A	Research Support, N.I.H., Extramural	A	NA
16	30492823	rs1064524	C	T	rs1064524	24556642	2.00E-07	(dfsSM)	0.54	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs1064524-T	Research Support, N.I.H., Extramural	C	ITGAL
16	30492823	rs1064524	C	T	rs1064524	24556642	2.07E-07	(dfsSM)	0.54	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs1064524-T	Research Support, N.I.H., Extramural	C	ITGAL
16	57297464	rs8046668	C	T	rs8046668	21940522	3.76E-05	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
16	79431853	rs4888966	G	C	rs4888966	23259602	5.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	C	NA
17	25567080	rs12602978	C	T	rs12602978	23064961	7.00E-07	DMFS5mand	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	C	LOC100506418
17	56492800	rs3744093	T	C	rs3744093	21940522	2.28E-05	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
17	56540267	rs3803752	C	T	rs3803752	21940522	2.93E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
17	56584205	rs2302189	A	C	rs2302189	21940522	8.00E-06	NA	1.33	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
17	56659018	rs6503870	C	T	rs6503870	21940522	5.43E-06	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
17	56708979	rs368243	T	C	rs368243	21940522	6.86E-06	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
17	56802141	rs304270	C	T	rs304270	21940522	7.51E-06	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
17	56953147	rs9911578	C	T	rs9911578	21940522	7.47E-06	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
17	57016525	rs7207693	C	T	rs7207693	21940522	1.11E-05	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
17	57139134	rs2333409	G	A	rs2333409	21940522	7.35E-05	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
17	79682051	rs3204270	C	A,G,T	rs3204270	23259602	5.00E-06	Comparatively Older	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	C	SLC25A10
18	9288456	rs2864527	T	G	rs2864527	23064961	4.00E-06	DMFS2	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	T	NA
18	11282319	rs7243066	G	A	rs7243066	23259602	9.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	G	NA
18	24687324	rs9961915	C	T	rs9961915	23259602	5.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	C	CHST9
18	36197047	rs4800037	G	A	rs4800037	24556642	9.60E-06	(dfsSM)	1.41	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs4800037-A	Research Support, N.I.H., Extramural	A	NA
18	36198732	rs11082098	C	A	rs11082098	24556642	1.68E-06	(dfsSM)	1.14	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs11082098-A	Research Support, N.I.H., Extramural	C	NA
18	36198732	rs11082098	C	A	rs11082098	24556642	2.00E-06	(dfsSM)	1.14	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs11082098-A	Research Support, N.I.H., Extramural	C	NA
18	36198732	rs11082098	C	A	rs11082098	24556642	2.63E-07	(dfsPF)	1.03	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs11082098-A	Research Support, N.I.H., Extramural	C	NA
18	36206783	rs9951903	C	T	rs9951903	24556642	6.96E-06	(dfsSM)	1.31	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs9951903-T	Research Support, N.I.H., Extramural	C	NA
18	36210292	rs7240129	C	T	rs7240129	24556642	7.00E-06	(dfsSM)	1.31	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs7240129-T	Research Support, N.I.H., Extramural	C	NA
18	36235593	rs3744906	C	T	rs3744906	24556642	6.96E-06	(dfsSM)	1.31	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs3744906-T	Research Support, N.I.H., Extramural	C	NA
18	46579970	rs357894	C	T	rs357894	23064961	4.00E-06	DMFS5max	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	T	DYM
18	47670024	rs973655	T	C	rs973655	21940522	1.03E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
18	65631583	rs9675979	A	G	rs9675979	21940522	1.25E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
18	71522091	rs17088439	T	G	rs17088439	24556642	3.00E-06	(dfsSM)	2.28	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17088439-T	Research Support, N.I.H., Extramural	T	NA
18	74318610	rs13381277	A	G	rs13381277	23064961	4.00E-06	DMFS3	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	G	NA
19	22554854	rs1865075	T	C	rs1865075	23259602	6.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	A	NA
19	22608374	rs10404998	T	C	rs10404998	23259602	3.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	T	NA
19	22614122	rs931608	A	C	rs931608	23064961	1.00E-06	DMFS5mand	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	A,C	NA
20	6186157	rs6076960	A	C	rs6076960	24556642	6.00E-06	(dfsSM)	1.27	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs6076960-A	Research Support, N.I.H., Extramural	A	NA
20	31749725	rs6120127	A	C	rs6120127	24556642	9.07E-06	(dfsSM)	4.71	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs6120127-A	Research Support, N.I.H., Extramural	C	NA
20	31753607	rs17124271	T	C	rs17124271	24556642	8.51E-06	(dfsSM)	4.72	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17124271-T	Research Support, N.I.H., Extramural	C	NA
20	31755539	rs7268823	G	T	rs7268823	24556642	8.45E-06	(dfsSM)	4.79	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs7268823-T	Research Support, N.I.H., Extramural	T	NA
20	31760708	rs6579083	G	A	rs6579083	24556642	8.76E-06	(dfsSM)	4.79	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs6579083-A	Research Support, N.I.H., Extramural	A	BPIFA2
20	31767704	rs8120668	C	G	rs8120668	24556642	8.95E-06	(dfsSM)	4.79	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs8120668-C	Research Support, N.I.H., Extramural	C	BPIFA2
20	31768655	rs6120141	T	C	rs6120141	24556642	3.00E-06	(dfsSM)	5.08	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs6120141-T	Research Support, N.I.H., Extramural	T	BPIFA2
20	31798437	rs17124372	T	C	rs17124372	24556642	2.00E-06	(dfsSM)	5.2	[NA] unit decrease	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17124372-T	Research Support, N.I.H., Extramural	T	NA
20	41991601	rs2010809	C	T	rs2010809	23470693	2.00E-06	NA	14.07	[NA] unit decrease	982 European ancestry individuals	European(982)	ALL(982)	EUR(982)	ALL(982)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs2010809-C	Research Support, N.I.H., Extramural	Comparative Study	G
20	62297802	rs6011002	A	G	rs6011002	23259602	3.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	A	RTEL1
21	15684254	rs1153330	G	A	rs1153330	21940522	2.69E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
21	30489300	rs2832191	A	C	rs2832191	23259602	5.00E-06	Comparatively Younger	NA	NA	1,483 comparatively younger European ancestry individuals; 5,960 comparatively older European ancestry individuals	European(7443)	ALL(7443)	EUR(7443)	ALL(7443)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Meta-Analysis	A	C21orf7
22	37199806	rs2022068	A	G	rs2022068	23470693	7.00E-06	NA	1.18	[NA] unit increase	996 European ancestry individuals	European(996)	ALL(996)	EUR(996)	ALL(996)	Pit-and-Fissure caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs2022068-A	Research Support, N.I.H., Extramural	Comparative Study	G
X	10037284	rs7059930	A	G	rs7059930	21940522	4.34E-04	NA	NA	NA	1,305 European ancestry children	European(1305)	ALL(1305)	EUR(1305)	ALL(1305)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
X	39885630	rs17145638	T	C	rs17145638	23470693	2.00E-07	NA	2.33	[NA] unit decrease	996 European ancestry individuals	European(996)	ALL(996)	EUR(996)	ALL(996)	Pit-and-Fissure caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs17145638-C	Research Support, N.I.H., Extramural	Comparative Study	T
X	85091520	rs5968700	C	T	rs5968700	24556642	1.09E-06	(dfsSM)	3.46	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs5968700-T	Research Support, N.I.H., Extramural	C	NA
X	85091520	rs5968700	C	T	rs5968700	24556642	3.16E-06	(dfsPF)	1.92	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs5968700-T	Research Support, N.I.H., Extramural	C	NA
X	85095739	rs5967638	G	A	rs5967638	24556642	1.31E-06	(dfsPF)	2.02	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs5967638-A	Research Support, N.I.H., Extramural	G	NA
X	85095739	rs5967638	G	A	rs5967638	24556642	8.00E-07	(dfsSM)	3.49	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs5967638-A	Research Support, N.I.H., Extramural	G	NA
X	85095739	rs5967638	G	A	rs5967638	24556642	8.33E-07	(dfsSM)	3.49	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs5967638-A	Research Support, N.I.H., Extramural	G	NA
X	129199812	rs3788848	T	C	rs3788848	23064961	3.00E-06	DMFS5,DMFS5max	NA	NA	920 European ancestry individuals	European(920)	ALL(920)	EUR(920)	ALL(920)	Dental caries	HPOID:0000670	Carious teeth	DOID:216	dental caries	D003731	Dental Caries	EFOID:0003819	dental caries	Tooth disease	NA	Research Support, N.I.H., Extramural	G	ELF4
X	133345288	rs12850804	C	T	rs12850804	24556642	1.69E-06	(dfsPF)	0.75	[NA] unit increase	1006 European ancestry individuals	European(1006)	ALL(1006)	EUR(1006)	ALL(1006)	Smooth-surface caries	HPOID:0011061	Abnormality of dental structure	DOID:216	dental caries	NA	NA	NA	NA	Tooth disease	rs12850804-T	Research Support, N.I.H., Extramural	C	NA

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:4)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0011334	aspartame	D001218	22839-47-0	dental caries	MESH:D003731	therapeutic	8955999
C0011334	methadone	D008691	76-99-3	dental caries	MESH:D003731	marker/mechanism	17687962
C0011334	morphine	D009020	57-27-2	dental caries	MESH:D003731	marker/mechanism	17687962
C0011334	zinc acetate	D019345	5970-45-6	dental caries	MESH:D003731	therapeutic	1771376

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)