PedAM

Pediatric Disease Annotations & Medicines


	dementia

Disease ID	735
Disease	dementia
Definition	loss of intellectual functions such as memory, learning, reasoning, problem solving, and abstract thinking while vegetative functions remain intact.
Synonym	[x] presenile dementia nos [x] presenile psychosis nos [x]presenile psychosis nos dementia presenile dementia, presenile pre senile dementia pre-senile dementia presenile dementia presenile dementia (disorder) presenile dementia nos presenile dementia nos (disorder) presenile dementia, nos presenile organic psychotic conditions
DOID	DOID:1307
UMLS	C0011265
MeSH	D003704
SNOMED-CT	SNOMEDCT_US_2016_09_01:12348006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:226) C0030567 \| parkinson's disease \| 137 C0011570 \| depression \| 129 C0002395 \| alzheimer's disease \| 85 C0011847 \| diabetes \| 68 C0002736 \| amyotrophic lateral sclerosis \| 29 C0524851 \| neurodegenerative disease \| 29 C0030567 \| parkinson disease \| 29 C0003467 \| anxiety \| 27 C0042373 \| vascular disease \| 25 C0011849 \| diabetes mellitus \| 24 C0002395 \| alzheimer disease \| 23 C0026848 \| myopathy \| 23 C0033975 \| psychosis \| 22 C0011860 \| type 2 diabetes \| 21 C0524851 \| neurodegenerative diseases \| 16 C0005586 \| bipolar disorder \| 15 C0752347 \| lewy body disease \| 12 C0679466 \| cognitive deficits \| 12 C0393571 \| multiple system atrophy \| 11 C0037317 \| sleep disturbance \| 10 C0020538 \| hypertension \| 10 C0011860 \| type 2 diabetes mellitus \| 10 C0085084 \| motor neuron disease \| 9 C0029401 \| paget's disease of bone \| 8 C0011269 \| vascular dementia \| 8 C0038868 \| progressive supranuclear palsy \| 8 C0338451 \| frontotemporal dementia \| 8 C0028754 \| obesity \| 8 C0004134 \| ataxia \| 8 C0032285 \| pneumonia \| 8 C0009241 \| cognitive disorders \| 8 C0029401 \| paget's disease \| 8 C0851578 \| sleep disorders \| 7 C0007222 \| cardiovascular disease \| 7 C0442874 \| neuropathy \| 7 C0014544 \| epilepsy \| 6 C0029401 \| paget disease \| 6 C0029401 \| paget disease of bone \| 6 C0026769 \| multiple sclerosis \| 5 C0042373 \| vascular diseases \| 5 C0259749 \| autonomic neuropathy \| 5 C0020255 \| hydrocephalus \| 5 C0003537 \| aphasia \| 5 C0085220 \| cerebral amyloid angiopathy \| 5 C0037317 \| sleep disturbances \| 5 C0002871 \| anemia \| 5 C0524851 \| neurodegenerative disorders \| 5 C0270612 \| leukoencephalopathy \| 4 C0162429 \| malnutrition \| 4 C0018799 \| heart disease \| 4 C0022661 \| chronic kidney disease \| 4 C0004153 \| atherosclerosis \| 4 C0018801 \| heart failure \| 4 C0042373 \| vascular disorder \| 3 C1561644 \| chronic kidney disease (ckd) \| 3 C0752347 \| dementia with lewy bodies \| 3 C0020179 \| huntington's disease \| 3 C0036341 \| schizophrenia \| 3 C0027765 \| neurological disorders \| 3 C0476254 \| dyslexia \| 3 C0024299 \| lymphoma \| 3 C0020538 \| high blood pressure \| 3 C0042075 \| urological disorders \| 3 C0020258 \| normal pressure hydrocephalus \| 3 C0041696 \| major depression \| 3 C0027765 \| neurological disorder \| 3 C0035078 \| renal failure \| 3 C0020676 \| hypothyroidism \| 3 C0025289 \| meningitis \| 3 C0003635 \| apraxia \| 3 C0162534 \| prion disease \| 3 C0022336 \| creutzfeldt-jakob disease \| 3 C0037315 \| sleep apnea \| 3 C0151313 \| sensory neuropathy \| 3 C0027765 \| neurological disease \| 3 C0699739 \| hereditary sensory neuropathy \| 3 C0006111 \| brain disease \| 3 C0020456 \| hyperglycemia \| 3 C0234507 \| anosognosia \| 3 C0042870 \| vitamin d deficiency \| 2 C0022658 \| kidney disease \| 2 C0027051 \| myocardial infarct \| 2 C0042373 \| vascular disorders \| 2 C0002892 \| pernicious anemia \| 2 C0020598 \| hypoglycaemia \| 2 C0028754 \| adiposity \| 2 C0042373 \| angiopathy \| 2 C0040188 \| tic disorders \| 2 C0270736 \| essential tremor \| 2 C0007222 \| cardiovascular diseases \| 2 C0003469 \| anxiety disorder \| 2 C0007787 \| transient ischemic attack \| 2 C0236642 \| pick disease \| 2 C0042870 \| vitamin d defic \| 2 C0027051 \| myocardial infarction \| 2 C0026884 \| mutism \| 2 C0042075 \| urological diseases \| 2 C0027868 \| neuromuscular disease \| 2 C0007758 \| cerebellar ataxia \| 2 C0020598 \| hypoglycemia \| 2 C0949664 \| tauopathies \| 2 C0029456 \| osteoporosis \| 2 C0006142 \| breast cancer \| 2 C0022116 \| ischemia \| 2 C0035579 \| hypovitaminosis d \| 2 C0220654 \| carcinomatous meningitis \| 2 C0242350 \| erectile dysfunction \| 2 C0020550 \| hyperthyroidism \| 2 C0948265 \| metabolic syndrome \| 2 C0751772 \| rem sleep behavior disorder \| 2 C0041327 \| pulmonary tuberculosis \| 1 C1389280 \| calcification of the basal ganglia \| 1 C0003469 \| anxiety disorders \| 1 C0027877 \| neuronal ceroid lipofuscinosis \| 1 C0001418 \| adenocarcinoma \| 1 C0242379 \| lung cancer \| 1 C0022660 \| acute renal failure \| 1 C0038436 \| post-traumatic stress disorder \| 1 C0019196 \| hepatitis c \| 1 C0022116 \| ischaemia \| 1 C0013080 \| trisomy 21 \| 1 C0027765 \| neurologic disorders \| 1 C0007121 \| bronchial carcinoma \| 1 C0017601 \| glaucoma \| 1 C1858581 \| aceruloplasminemia \| 1 C0029124 \| optic atrophy \| 1 C0040553 \| toxocariasis \| 1 C0019187 \| alcoholic hepatitis \| 1 C0878544 \| cardiomyopathy \| 1 C0206368 \| pseudoexfoliation syndrome \| 1 C0027849 \| neuroleptic malignant syndrome \| 1 C0011127 \| pressure sores \| 1 C0022797 \| ceroid lipofuscinosis \| 1 C0024117 \| chronic obstructive pulmonary disease \| 1 C0598608 \| hyperhomocysteinemia \| 1 C0032460 \| polycystic ovary syndrome \| 1 C0001973 \| alcoholism \| 1 C0040558 \| toxoplasmosis \| 1 C0022568 \| keratitis \| 1 C0020443 \| hypercholesterolemia \| 1 C0007786 \| brain ischemia \| 1 C0041696 \| major depressive disorder \| 1 C0032460 \| polycystic ovary \| 1 C0030442 \| bulbar palsy \| 1 C0007820 \| cerebrovascular disorders \| 1 C0011860 \| diabetes mellitus type 2 \| 1 C0152025 \| polyneuropathy \| 1 C0026850 \| muscular dystrophy \| 1 C0149925 \| small cell lung cancer \| 1 C0007820 \| cerebrovascular disorder \| 1 C0206019 \| hiv encephalopathy \| 1 C0085084 \| motor neurone disease \| 1 C0022283 \| hypomelanosis of ito \| 1 C0037315 \| sleep-disordered breathing \| 1 C0152013 \| lung adenocarcinoma \| 1 C0030567 \| idiopathic parkinson disease \| 1 C0151620 \| hypertensive encephalopathy \| 1 C0085436 \| cryptococcal meningitis \| 1 C0042769 \| viral infection \| 1 C0206368 \| exfoliation syndrome \| 1 C0743039 \| progressive dementia \| 1 C0549423 \| obstructive hydrocephalus \| 1 C0024437 \| macular degeneration \| 1 C0033790 \| pseudobulbar palsy \| 1 C0162316 \| iron-deficiency anemia \| 1 C0017612 \| open-angle glaucoma \| 1 C0024437 \| age-related macular degeneration \| 1 C0007785 \| cerebral infarct \| 1 C0276548 \| hiv encephalitis \| 1 C0162429 \| undernutrition \| 1 C0026848 \| muscular diseases \| 1 C0085278 \| antiphospholipid syndrome \| 1 C0027145 \| myxedema \| 1 C0011127 \| decubitus \| 1 C0270549 \| generalized anxiety disorder \| 1 C0022661 \| chronic renal failure \| 1 C0155765 \| microangiopathy \| 1 C0013421 \| dystonia \| 1 C1565489 \| renal insufficiency \| 1 C0027765 \| neurologic disorder \| 1 C0007113 \| rectal cancer \| 1 C0035258 \| restless legs syndrome (rls) \| 1 C0683323 \| physical illness \| 1 C0002726 \| amyloidosis \| 1 C0019158 \| hepatitis \| 1 C0007785 \| cerebral infarction \| 1 C0024115 \| pulmonary disease \| 1 C0014038 \| encephalitis \| 1 C0021053 \| immune disease \| 1 C0686353 \| limb girdle muscular dystrophy \| 1 C0011860 \| non-insulin-dependent diabetes mellitus \| 1 C0006111 \| brain disorder \| 1 C0006111 \| brain diseases \| 1 C0398623 \| hypercoagulable state \| 1 C1527336 \| sjogren's syndrome \| 1 C0027868 \| neuromuscular diseases \| 1 C0008479 \| chondrosarcoma \| 1 C0011854 \| insulin-dependent diabetes \| 1 C0026848 \| muscle disease \| 1 C0002871 \| anaemia \| 1 C0030486 \| paraplegia \| 1 C0025309 \| meningoencephalitis \| 1 C0011854 \| type 1 diabetes \| 1 C0003864 \| arthritis \| 1 C0024408 \| spinocerebellar ataxia type 3 \| 1 C0007570 \| celiac disease \| 1 C0011991 \| diarrhea \| 1 C0035309 \| retinopathy \| 1 C0034494 \| rabies \| 1 C0013415 \| dysthymia \| 1 C0014547 \| partial epilepsy \| 1 C0009402 \| colorectal cancer \| 1 C0162534 \| prion diseases \| 1 C0752347 \| lewy body dementia \| 1 C0030662 \| pathological gambling \| 1 C0085580 \| essential hypertension \| 1 C0019196 \| hepatitis c infection \| 1 C0007282 \| carotid stenosis \| 1 C0023882 \| spastic diplegia \| 1 C0282492 \| sneddon syndrome \| 1 C0600260 \| obstructive pulmonary disease \| 1 C0028064 \| niemann-pick disease \| 1 C0002766 \| analgesia \| 1 C0018099 \| gout \| 1 C0011854 \| insulin-dependent diabetes mellitus \| 1 C0742472 \| central nervous system lymphoma \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:64) 19 \| ABCA1 \| infer 20 \| ABCA2 \| infer 38 \| ACAT1 \| infer 39 \| ACAT2 \| infer 1636 \| ACE \| infer 196 \| AHR \| infer 335 \| APOA1 \| infer 338 \| APOB \| infer 348 \| APOE \| infer 351 \| APP \| infer 91647 \| ATPAF2 \| infer 590 \| BCHE \| infer 1952 \| CELSR2 \| infer 1071 \| CETP \| infer 25978 \| CHMP2B \| infer 1312 \| COMT \| infer 1471 \| CST3 \| infer 1592 \| CYP26A1 \| infer 1821 \| DRP2 \| infer 2099 \| ESR1 \| infer 2348 \| FOLR1 \| infer 2590 \| GALNT2 \| infer 2646 \| GCKR \| infer 2896 \| GRN \| infer 3105 \| HLA-A \| infer 3156 \| HMGCR \| infer 3569 \| IL6 \| infer 3931 \| LCAT \| infer 3949 \| LDLR \| infer 3990 \| LIPC \| infer 9388 \| LIPG \| infer 4023 \| LPL \| infer 4035 \| LRP1 \| infer 7804 \| LRP8 \| infer 120892 \| LRRK2 \| infer 4128 \| MAOA \| infer 4137 \| MAPT \| infer 10747 \| MASP2 \| infer 4153 \| MBL2 \| infer 51085 \| MLXIPL \| infer 4318 \| MMP9 \| infer 4524 \| MTHFR \| infer 10 \| NAT2 \| infer 2908 \| NR3C1 \| infer 11315 \| PARK7 \| infer 255738 \| PCSK9 \| infer 5360 \| PLTP \| infer 5444 \| PON1 \| infer 5468 \| PPARG \| infer 5621 \| PRNP \| infer 5663 \| PSEN1 \| infer 5664 \| PSEN2 \| infer 84722 \| PSRC1 \| infer 949 \| SCARB1 \| infer 5274 \| SERPINI1 \| infer 6622 \| SNCA \| infer 6272 \| SORT1 \| infer 6720 \| SREBF1 \| infer 6721 \| SREBF2 \| infer 7040 \| TGFB1 \| infer 7124 \| TNF \| infer 146691 \| TOM1L2 \| infer 7298 \| TYMS \| infer 7436 \| VLDLR \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:772) 618 \| BCYRN1 \| DISEASES 8847 \| DLEU2 \| DISEASES 10368 \| CACNG3 \| DISEASES 6376 \| CX3CL1 \| DISEASES 79090 \| TRAPPC6A \| DISEASES 6856 \| SYPL1 \| DISEASES 11345 \| GABARAPL2 \| DISEASES 2896 \| GRN \| DISEASES 4804 \| NGFR \| DISEASES 5351 \| PLOD1 \| DISEASES 51314 \| NME8 \| DISEASES 1071 \| CETP \| DISEASES 4504 \| MT3 \| DISEASES 51291 \| GMIP \| DISEASES 51324 \| SPG21 \| DISEASES 1738 \| DLD \| DISEASES 2099 \| ESR1 \| DISEASES 23411 \| SIRT1 \| DISEASES 5594 \| MAPK1 \| DISEASES 3162 \| HMOX1 \| DISEASES 410 \| ARSA \| DISEASES 5816 \| PVALB \| DISEASES 1113 \| CHGA \| DISEASES 10278 \| EFS \| DISEASES 5173 \| PDYN \| DISEASES 5020 \| OXT \| DISEASES 140679 \| SLC32A1 \| DISEASES 7076 \| TIMP1 \| DISEASES 479 \| ATP12A \| DISEASES 123876 \| ACSM2A \| DISEASES 4313 \| MMP2 \| DISEASES 79152 \| FA2H \| DISEASES 10273 \| STUB1 \| DISEASES 1666 \| DECR1 \| DISEASES 5327 \| PLAT \| DISEASES 4741 \| NEFM \| DISEASES 4849 \| CNOT3 \| DISEASES 11129 \| CLASRP \| DISEASES 57030 \| SLC17A7 \| DISEASES 333 \| APLP1 \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 6822 \| SULT2A1 \| DISEASES 5864 \| RAB3A \| DISEASES 55851 \| PSENEN \| DISEASES 23770 \| FKBP8 \| DISEASES 5444 \| PON1 \| DISEASES 5054 \| SERPINE1 \| DISEASES 7431 \| VIM \| DISEASES 6348 \| CCL3 \| DISEASES 6347 \| CCL2 \| DISEASES 4669 \| NAGLU \| DISEASES 173 \| AFM \| DISEASES 3558 \| IL2 \| DISEASES 51166 \| AADAT \| DISEASES 3312 \| HSPA8 \| DISEASES 79073 \| TMEM109 \| DISEASES 10944 \| C11orf58 \| DISEASES 3458 \| IFNG \| DISEASES 2026 \| ENO2 \| DISEASES 1432 \| MAPK14 \| DISEASES 6908 \| TBP \| DISEASES 9450 \| LY86 \| DISEASES 3565 \| IL4 \| DISEASES 4057 \| LTF \| DISEASES 80325 \| ABTB1 \| DISEASES 338 \| APOB \| DISEASES 7781 \| SLC30A3 \| DISEASES 10153 \| CEBPZ \| DISEASES 2023 \| ENO1 \| DISEASES 1509 \| CTSD \| DISEASES 335 \| APOA1 \| DISEASES 7276 \| TTR \| DISEASES 2691 \| GHRH \| DISEASES 4709 \| NDUFB3 \| DISEASES 10971 \| YWHAQ \| DISEASES 1958 \| EGR1 \| DISEASES 23435 \| TARDBP \| DISEASES 3375 \| IAPP \| DISEASES 847 \| CAT \| DISEASES 4852 \| NPY \| DISEASES 540 \| ATP7B \| DISEASES 4035 \| LRP1 \| DISEASES 10888 \| GPR83 \| DISEASES 5184 \| PEPD \| DISEASES 667 \| DST \| DISEASES 6310 \| ATXN1 \| DISEASES 2806 \| GOT2 \| DISEASES 83541 \| FAM110A \| DISEASES 391013 \| PLA2G2C \| DISEASES 3315 \| HSPB1 \| DISEASES 2678 \| GGT1 \| DISEASES 7425 \| VGF \| DISEASES 54982 \| CLN6 \| DISEASES 7166 \| TPH1 \| DISEASES 968 \| CD68 \| DISEASES 6351 \| CCL4 \| DISEASES 3630 \| INS \| DISEASES 57488 \| ESYT2 \| DISEASES 9509 \| ADAMTS2 \| DISEASES 348 \| APOE \| DISEASES 10452 \| TOMM40 \| DISEASES 341 \| APOC1 \| DISEASES 55821 \| ALLC \| DISEASES 25814 \| ATXN10 \| DISEASES 8666 \| EIF3G \| DISEASES 2670 \| GFAP \| DISEASES 7376 \| NR1H2 \| DISEASES 314 \| AOC2 \| DISEASES 2521 \| FUS \| DISEASES 2926 \| GRSF1 \| DISEASES 91107 \| TRIM47 \| DISEASES 182 \| JAG1 \| DISEASES 6616 \| SNAP25 \| DISEASES 1401 \| CRP \| DISEASES 325 \| APCS \| DISEASES 91703 \| ACY3 \| DISEASES 1116 \| CHI3L1 \| DISEASES 84626 \| KRBA1 \| DISEASES 4922 \| NTS \| DISEASES 759 \| CA1 \| DISEASES 6272 \| SORT1 \| DISEASES 2694 \| GIF \| DISEASES 6926 \| TBX3 \| DISEASES 27429 \| HTRA2 \| DISEASES 55198 \| APPL2 \| DISEASES 3569 \| IL6 \| DISEASES 55852 \| TEX2 \| DISEASES 7097 \| TLR2 \| DISEASES 6653 \| SORL1 \| DISEASES 102 \| ADAM10 \| DISEASES 9360 \| PPIG \| DISEASES 10060 \| ABCC9 \| DISEASES 4659 \| PPP1R12A \| DISEASES 5037 \| PEBP1 \| DISEASES 5858 \| PZP \| DISEASES 9627 \| SNCAIP \| DISEASES 7450 \| VWF \| DISEASES 1800 \| DPEP1 \| DISEASES 6532 \| SLC6A4 \| DISEASES 642 \| BLMH \| DISEASES 10858 \| CYP46A1 \| DISEASES 55930 \| MYO5C \| DISEASES 84888 \| SPPL2A \| DISEASES 80208 \| SPG11 \| DISEASES 23531 \| MMD \| DISEASES 79726 \| WDR59 \| DISEASES 22850 \| ADNP2 \| DISEASES 10101 \| NUBP2 \| DISEASES 284058 \| KANSL1 \| DISEASES 10558 \| SPTLC1 \| DISEASES 495 \| ATP4A \| DISEASES 7305 \| TYROBP \| DISEASES 25939 \| SAMHD1 \| DISEASES 57787 \| MARK4 \| DISEASES 5595 \| MAPK3 \| DISEASES 10347 \| ABCA7 \| DISEASES 6855 \| SYP \| DISEASES 2033 \| EP300 \| DISEASES 4858 \| NOVA2 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 23476 \| BRD4 \| DISEASES 4854 \| NOTCH3 \| DISEASES 9441 \| MED26 \| DISEASES 492 \| ATP2B3 \| DISEASES 334 \| APLP2 \| DISEASES 9828 \| ARHGEF17 \| DISEASES 4722 \| NDUFS3 \| DISEASES 25978 \| CHMP2B \| DISEASES 1001 \| CDH3 \| DISEASES 11181 \| TREH \| DISEASES 60482 \| SLC5A7 \| DISEASES 10190 \| TXNDC9 \| DISEASES 57679 \| ALS2 \| DISEASES 57606 \| SLAIN2 \| DISEASES 590 \| BCHE \| DISEASES 2247 \| FGF2 \| DISEASES 1356 \| CP \| DISEASES 5443 \| POMC \| DISEASES 3383 \| ICAM1 \| DISEASES 950 \| SCARB2 \| DISEASES 27146 \| FAM184B \| DISEASES 7879 \| RAB7A \| DISEASES 64083 \| GOLPH3 \| DISEASES 6507 \| SLC1A3 \| DISEASES 839 \| CASP6 \| DISEASES 1950 \| EGF \| DISEASES 10371 \| SEMA3A \| DISEASES 793 \| CALB1 \| DISEASES 51083 \| GAL \| DISEASES 5243 \| ABCB1 \| DISEASES 51608 \| GET4 \| DISEASES 55749 \| CCAR1 \| DISEASES 3416 \| IDE \| DISEASES 1795 \| DOCK3 \| DISEASES 3700 \| ITIH4 \| DISEASES 25793 \| FBXO7 \| DISEASES 3073 \| HEXA \| DISEASES 5045 \| FURIN \| DISEASES 1039 \| CDR2 \| DISEASES 4864 \| NPC1 \| DISEASES 7157 \| TP53 \| DISEASES 201292 \| TRIM65 \| DISEASES 55527 \| FEM1A \| DISEASES 6647 \| SOD1 \| DISEASES 150094 \| SIK1 \| DISEASES 207 \| AKT1 \| DISEASES 79760 \| GEMIN7 \| DISEASES 6531 \| SLC6A3 \| DISEASES 5141 \| PDE4A \| DISEASES 402665 \| IGLON5 \| DISEASES 54874 \| FNBP1L \| DISEASES 5298 \| PI4KB \| DISEASES 5972 \| REN \| DISEASES 805 \| CALM2 \| DISEASES 23190 \| UBXN4 \| DISEASES 5868 \| RAB5A \| DISEASES 185 \| AGTR1 \| DISEASES 275 \| AMT \| DISEASES 10769 \| PLK2 \| DISEASES 7941 \| PLA2G7 \| DISEASES 474343 \| SPIN2B \| DISEASES 3358 \| HTR2C \| DISEASES 1392 \| CRH \| DISEASES 10280 \| SIGMAR1 \| DISEASES 4915 \| NTRK2 \| DISEASES 5047 \| PAEP \| DISEASES 4851 \| NOTCH1 \| DISEASES 6506 \| SLC1A2 \| DISEASES 740 \| MRPL49 \| DISEASES 2904 \| GRIN2B \| DISEASES 196383 \| RILPL2 \| DISEASES 23657 \| SLC7A11 \| DISEASES 9472 \| AKAP6 \| DISEASES 7082 \| TJP1 \| DISEASES 5741 \| PTH \| DISEASES 2911 \| GRM1 \| DISEASES 153478 \| PLEKHG4B \| DISEASES 57338 \| JPH3 \| DISEASES 4900 \| NRGN \| DISEASES 2838 \| GPR15 \| DISEASES 7345 \| UCHL1 \| DISEASES 23643 \| LY96 \| DISEASES 351 \| APP \| DISEASES 2890 \| GRIA1 \| DISEASES 1436 \| CSF1R \| DISEASES 132 \| ADK \| DISEASES 26285 \| CLDN17 \| DISEASES 55093 \| WDYHV1 \| DISEASES 6750 \| SST \| DISEASES 5468 \| PPARG \| DISEASES 3361 \| HTR5A \| DISEASES 3156 \| HMGCR \| DISEASES 909 \| CD1A \| DISEASES 3362 \| HTR6 \| DISEASES 8883 \| NAE1 \| DISEASES 1636 \| ACE \| DISEASES 808 \| CALM3 \| DISEASES 5316 \| PKNOX1 \| DISEASES 1476 \| CSTB \| DISEASES 8209 \| C21orf33 \| DISEASES 6285 \| S100B \| DISEASES 729230 \| CCR2 \| DISEASES 1234 \| CCR5 \| DISEASES 1627 \| DBN1 \| DISEASES 85451 \| UNK \| DISEASES 6352 \| CCL5 \| DISEASES 3060 \| HCRT \| DISEASES 126133 \| ALDH16A1 \| DISEASES 1742 \| DLG4 \| DISEASES 7412 \| VCAM1 \| DISEASES 23385 \| NCSTN \| DISEASES 2215 \| FCGR3B \| DISEASES 440699 \| LRRC52 \| DISEASES 7447 \| VSNL1 \| DISEASES 5274 \| SERPINI1 \| DISEASES 213 \| ALB \| DISEASES 57406 \| ABHD6 \| DISEASES 6853 \| SYN1 \| DISEASES 256471 \| MFSD8 \| DISEASES 4131 \| MAP1B \| DISEASES 9607 \| CARTPT \| DISEASES 4846 \| NOS3 \| DISEASES 145581 \| LRFN5 \| DISEASES 115825 \| WDFY2 \| DISEASES 114088 \| TRIM9 \| DISEASES 6571 \| SLC18A2 \| DISEASES 120892 \| LRRK2 \| DISEASES 55737 \| VPS35 \| DISEASES 5092 \| PCBD1 \| DISEASES 322 \| APBB1 \| DISEASES 1200 \| TPP1 \| DISEASES 29781 \| NCAPH2 \| DISEASES 89832 \| CHRFAM7A \| DISEASES 124872 \| B4GALNT2 \| DISEASES 762 \| CA4 \| DISEASES 2819 \| GPD1 \| DISEASES 51293 \| CD320 \| DISEASES 1632 \| ECI1 \| DISEASES 80150 \| ASRGL1 \| DISEASES 4054 \| LTBP3 \| DISEASES 53354 \| PANK1 \| DISEASES 5617 \| PRL \| DISEASES 79058 \| ASPSCR1 \| DISEASES 116844 \| LRG1 \| DISEASES 3479 \| IGF1 \| DISEASES 414301 \| DDI1 \| DISEASES 3308 \| HSPA4 \| DISEASES 10972 \| TMED10 \| DISEASES 43 \| ACHE \| DISEASES 51181 \| DCXR \| DISEASES 8988 \| HSPB3 \| DISEASES 7200 \| TRH \| DISEASES 6249 \| CLIP1 \| DISEASES 7804 \| LRP8 \| DISEASES 7857 \| SCG2 \| DISEASES 7314 \| UBB \| DISEASES 3667 \| IRS1 \| DISEASES 5354 \| PLP1 \| DISEASES 1051 \| CEBPB \| DISEASES 3627 \| CXCL10 \| DISEASES 2915 \| GRM5 \| DISEASES 2353 \| FOS \| DISEASES 3708 \| ITPR1 \| DISEASES 1128 \| CHRM1 \| DISEASES 2186 \| BPTF \| DISEASES 794 \| CALB2 \| DISEASES 79415 \| C17orf62 \| DISEASES 54205 \| CYCS \| DISEASES 5986 \| RFNG \| DISEASES 6620 \| SNCB \| DISEASES 64978 \| MRPL38 \| DISEASES 134 \| ADORA1 \| DISEASES 9575 \| CLOCK \| DISEASES 5340 \| PLG \| DISEASES 572 \| BAD \| DISEASES 5653 \| KLK6 \| DISEASES 254295 \| PHYHD1 \| DISEASES 1808 \| DPYSL2 \| DISEASES 6868 \| ADAM17 \| DISEASES 56945 \| MRPS22 \| DISEASES 8722 \| CTSF \| DISEASES 27235 \| COQ2 \| DISEASES 836 \| CASP3 \| DISEASES 7423 \| VEGFB \| DISEASES 266743 \| NPAS4 \| DISEASES 5978 \| REST \| DISEASES 4744 \| NEFH \| DISEASES 5319 \| PLA2G1B \| DISEASES 8639 \| AOC3 \| DISEASES 8557 \| TCAP \| DISEASES 3952 \| LEP \| DISEASES 51762 \| RAB8B \| DISEASES 124925 \| SEZ6 \| DISEASES 80025 \| PANK2 \| DISEASES 51130 \| ASB3 \| DISEASES 713 \| C1QB \| DISEASES 116138 \| KLHDC3 \| DISEASES 6844 \| VAMP2 \| DISEASES 51593 \| SRRT \| DISEASES 2629 \| GBA \| DISEASES 6448 \| SGSH \| DISEASES 1191 \| CLU \| DISEASES 23268 \| DNMBP \| DISEASES 64231 \| MS4A6A \| DISEASES 6440 \| SFTPC \| DISEASES 3350 \| HTR1A \| DISEASES 55690 \| PACS1 \| DISEASES 274 \| BIN1 \| DISEASES 64755 \| C16orf58 \| DISEASES 9475 \| ROCK2 \| DISEASES 79649 \| MAP7D3 \| DISEASES 55626 \| AMBRA1 \| DISEASES 4684 \| NCAM1 \| DISEASES 23621 \| BACE1 \| DISEASES 377677 \| CA13 \| DISEASES 8834 \| TMEM11 \| DISEASES 54822 \| TRPM7 \| DISEASES 9520 \| NPEPPS \| DISEASES 9370 \| ADIPOQ \| DISEASES 1827 \| RCAN1 \| DISEASES 6683 \| SPAST \| DISEASES 6863 \| TAC1 \| DISEASES 4018 \| LPA \| DISEASES 84938 \| ATG4C \| DISEASES 4312 \| MMP1 \| DISEASES 3355 \| HTR1F \| DISEASES 84066 \| TEX35 \| DISEASES 2 \| A2M \| DISEASES 3309 \| HSPA5 \| DISEASES 2932 \| GSK3B \| DISEASES 9884 \| LRRC37A \| DISEASES 5663 \| PSEN1 \| DISEASES 1237 \| CCR8 \| DISEASES 80758 \| PRR7 \| DISEASES 23400 \| ATP13A2 \| DISEASES 23467 \| NPTXR \| DISEASES 1812 \| DRD1 \| DISEASES 2055 \| CLN8 \| DISEASES 706 \| TSPO \| DISEASES 51400 \| PPME1 \| DISEASES 255022 \| CALHM1 \| DISEASES 842 \| CASP9 \| DISEASES 277 \| AMY1B \| DISEASES 9951 \| HS3ST4 \| DISEASES 375287 \| RBM43 \| DISEASES 6401 \| SELE \| DISEASES 1675 \| CFD \| DISEASES 23283 \| CSTF2T \| DISEASES 162540 \| SPPL2C \| DISEASES 2903 \| GRIN2A \| DISEASES 2185 \| PTK2B \| DISEASES 25825 \| BACE2 \| DISEASES 9939 \| RBM8A \| DISEASES 8398 \| PLA2G6 \| DISEASES 55256 \| ADI1 \| DISEASES 153571 \| C5orf38 \| DISEASES 340069 \| FAM170A \| DISEASES 27445 \| PCLO \| DISEASES 140890 \| SREK1 \| DISEASES 10810 \| WASF3 \| DISEASES 51738 \| GHRL \| DISEASES 3320 \| HSP90AA1 \| DISEASES 885 \| CCK \| DISEASES 5521 \| PPP2R2B \| DISEASES 25771 \| TBC1D22A \| DISEASES 1103 \| CHAT \| DISEASES 3988 \| LIPA \| DISEASES 4842 \| NOS1 \| DISEASES 1641 \| DCX \| DISEASES 57142 \| RTN4 \| DISEASES 3363 \| HTR7 \| DISEASES 6622 \| SNCA \| DISEASES 7327 \| UBE2G2 \| DISEASES 23583 \| SMUG1 \| DISEASES 8835 \| SOCS2 \| DISEASES 11315 \| PARK7 \| DISEASES 6609 \| SMPD1 \| DISEASES 5910 \| RAP1GDS1 \| DISEASES 6575 \| SLC20A2 \| DISEASES 4128 \| MAOA \| DISEASES 4137 \| MAPT \| DISEASES 113675 \| SDSL \| DISEASES 2359 \| FPR3 \| DISEASES 9588 \| PRDX6 \| DISEASES 1508 \| CTSB \| DISEASES 11255 \| HRH3 \| DISEASES 10979 \| FERMT2 \| DISEASES 23394 \| ADNP \| DISEASES 4077 \| NBR1 \| DISEASES 2100 \| ESR2 \| DISEASES 10313 \| RTN3 \| DISEASES 875 \| CBS \| DISEASES 144165 \| PRICKLE1 \| DISEASES 29978 \| UBQLN2 \| DISEASES 3516 \| RBPJ \| DISEASES 378884 \| NHLRC1 \| DISEASES 2534 \| FYN \| DISEASES 25847 \| ANAPC13 \| DISEASES 3064 \| HTT \| DISEASES 100506658 \| OCLN \| DISEASES 6904 \| TBCD \| DISEASES 1785 \| DNM2 \| DISEASES 355 \| FAS \| DISEASES 26503 \| SLC17A5 \| DISEASES 5265 \| SERPINA1 \| DISEASES 3240 \| HP \| DISEASES 120 \| ADD3 \| DISEASES 11152 \| WDR45 \| DISEASES 23646 \| PLD3 \| DISEASES 23237 \| ARC \| DISEASES 1822 \| ATN1 \| DISEASES 8794 \| TNFRSF10C \| DISEASES 801 \| CALM1 \| DISEASES 54798 \| DCHS2 \| DISEASES 60 \| ACTB \| DISEASES 1121 \| CHM \| DISEASES 23224 \| SYNE2 \| DISEASES 51460 \| SFMBT1 \| DISEASES 26136 \| TES \| DISEASES 1524 \| CX3CR1 \| DISEASES 10242 \| KCNMB2 \| DISEASES 84735 \| CNDP1 \| DISEASES 7415 \| VCP \| DISEASES 165679 \| SPTSSB \| DISEASES 5294 \| PIK3CG \| DISEASES 617 \| BCS1L \| DISEASES 2547 \| XRCC6 \| DISEASES 23607 \| CD2AP \| DISEASES 8936 \| WASF1 \| DISEASES 1786 \| DNMT1 \| DISEASES 10814 \| CPLX2 \| DISEASES 3635 \| INPP5D \| DISEASES 126014 \| OSCAR \| DISEASES 1201 \| CLN3 \| DISEASES 51150 \| SDF4 \| DISEASES 79947 \| DHDDS \| DISEASES 773 \| CACNA1A \| DISEASES 1523 \| CUX1 \| DISEASES 5575 \| PRKAR1B \| DISEASES 5869 \| RAB5B \| DISEASES 57091 \| CASS4 \| DISEASES 5599 \| MAPK8 \| DISEASES 4133 \| MAP2 \| DISEASES 4311 \| MME \| DISEASES 1066 \| CES1 \| DISEASES 1803 \| DPP4 \| DISEASES 11076 \| TPPP \| DISEASES 283807 \| FBXL22 \| DISEASES 1565 \| CYP2D6 \| DISEASES 56891 \| LGALS14 \| DISEASES 3360 \| HTR4 \| DISEASES 6533 \| SLC6A6 \| DISEASES 80331 \| DNAJC5 \| DISEASES 6772 \| STAT1 \| DISEASES 1312 \| COMT \| DISEASES 2475 \| MTOR \| DISEASES 5742 \| PTGS1 \| DISEASES 4976 \| OPA1 \| DISEASES 26047 \| CNTNAP2 \| DISEASES 1639 \| DCTN1 \| DISEASES 1813 \| DRD2 \| DISEASES 4283 \| CXCL9 \| DISEASES 4514 \| MT-CO3 \| DISEASES 56259 \| CTNNBL1 \| DISEASES 8678 \| BECN1 \| DISEASES 23038 \| WDTC1 \| DISEASES 1270 \| CNTF \| DISEASES 183 \| AGT \| DISEASES 5664 \| PSEN2 \| DISEASES 142 \| PARP1 \| DISEASES 83881 \| MIXL1 \| DISEASES 5071 \| PARK2 \| DISEASES 343035 \| RD3 \| DISEASES 1378 \| CR1 \| DISEASES 7432 \| VIP \| DISEASES 5743 \| PTGS2 \| DISEASES 7957 \| EPM2A \| DISEASES 51534 \| VTA1 \| DISEASES 55103 \| RALGPS2 \| DISEASES 462 \| SERPINC1 \| DISEASES 2214 \| FCGR3A \| DISEASES 10763 \| NES \| DISEASES 3713 \| IVL \| DISEASES 5654 \| HTRA1 \| DISEASES 5550 \| PREP \| DISEASES 23195 \| MDN1 \| DISEASES 26227 \| PHGDH \| DISEASES 126868 \| MAB21L3 \| DISEASES 4803 \| NGF \| DISEASES 9446 \| GSTO1 \| DISEASES 112611 \| RWDD2A \| DISEASES 278 \| AMY1C \| DISEASES 276 \| AMY1A \| DISEASES 1137 \| CHRNA4 \| DISEASES 1369 \| CPN1 \| DISEASES 2332 \| FMR1 \| DISEASES 4923 \| NTSR1 \| DISEASES 1038 \| CDR1 \| DISEASES 959 \| CD40LG \| DISEASES 55361 \| PI4K2A \| DISEASES 51442 \| VGLL1 \| DISEASES 9406 \| ZRANB2 \| DISEASES 55970 \| GNG12 \| DISEASES 1791 \| DNTT \| DISEASES 3725 \| JUN \| DISEASES 1557 \| CYP2C19 \| DISEASES 9211 \| LGI1 \| DISEASES 2902 \| GRIN1 \| DISEASES 5730 \| PTGDS \| DISEASES 6623 \| SNCG \| DISEASES 7422 \| VEGFA \| DISEASES 4318 \| MMP9 \| DISEASES 5476 \| CTSA \| DISEASES 1759 \| DNM1 \| DISEASES 54209 \| TREM2 \| DISEASES 29988 \| SLC2A8 \| DISEASES 5292 \| PIM1 \| DISEASES 2833 \| CXCR3 \| DISEASES 2170 \| FABP3 \| DISEASES 29119 \| CTNNA3 \| DISEASES 2934 \| GSN \| DISEASES 7099 \| TLR4 \| DISEASES 6572 \| SLC18A3 \| DISEASES 57134 \| MAN1C1 \| DISEASES 5252 \| PHF1 \| DISEASES 259283 \| MDS2 \| DISEASES 8518 \| IKBKAP \| DISEASES 3339 \| HSPG2 \| DISEASES 19 \| ABCA1 \| DISEASES 1889 \| ECE1 \| DISEASES 54466 \| SPIN2A \| DISEASES 7046 \| TGFBR1 \| DISEASES 4855 \| NOTCH4 \| DISEASES 65018 \| PINK1 \| DISEASES 3376 \| IARS \| DISEASES 6850 \| SYK \| DISEASES 23509 \| POFUT1 \| DISEASES 1282 \| COL4A1 \| DISEASES 3055 \| HCK \| DISEASES 79180 \| EFHD2 \| DISEASES 199 \| AIF1 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 1041 \| CDSN \| DISEASES 29979 \| UBQLN1 \| DISEASES 56243 \| KIAA1217 \| DISEASES 4524 \| MTHFR \| DISEASES 353116 \| RILPL1 \| DISEASES 1471 \| CST3 \| DISEASES 1676 \| DFFA \| DISEASES 1325 \| CORT \| DISEASES 80036 \| TRPM3 \| DISEASES 22883 \| CLSTN1 \| DISEASES 5293 \| PIK3CD \| DISEASES 6518 \| SLC2A5 \| DISEASES 1203 \| CLN5 \| DISEASES 6311 \| ATXN2 \| DISEASES 57449 \| PLEKHG5 \| DISEASES 51028 \| VPS36 \| DISEASES 4129 \| MAOB \| DISEASES 414062 \| CCL3L3 \| DISEASES 9651 \| PLCH2 \| DISEASES 9445 \| ITM2B \| DISEASES 6354 \| CCL7 \| DISEASES 1536 \| CYBB \| DISEASES 27089 \| UQCRQ \| DISEASES 3356 \| HTR2A \| DISEASES 4897 \| NRCAM \| DISEASES 51335 \| NGRN \| DISEASES 2625 \| GATA3 \| DISEASES 55676 \| SLC30A6 \| DISEASES 375790 \| AGRN \| DISEASES 1906 \| EDN1 \| DISEASES 5621 \| PRNP \| DISEASES 146691 \| TOM1L2 \| DISEASES 161003 \| STOML3 \| DISEASES 4081 \| MAB21L1 \| DISEASES 203228 \| C9orf72 \| DISEASES 9365 \| KL \| DISEASES 3446 \| IFNA10 \| DISEASES 551 \| AVP \| DISEASES 10184 \| LHFPL2 \| DISEASES 8544 \| PIR \| DISEASES 6462 \| SHBG \| DISEASES 6526 \| SLC5A3 \| DISEASES 7054 \| TH \| DISEASES 51378 \| ANGPT4 \| DISEASES 7436 \| VLDLR \| DISEASES 55504 \| TNFRSF19 \| DISEASES 4155 \| MBP \| DISEASES 387733 \| IFITM5 \| DISEASES 361 \| AQP4 \| DISEASES 1814 \| DRD3 \| DISEASES 348801 \| LNP1 \| DISEASES 22895 \| RPH3A \| DISEASES 8878 \| SQSTM1 \| DISEASES 54476 \| RNF216 \| DISEASES 83636 \| C19orf12 \| DISEASES 12 \| SERPINA3 \| DISEASES 4287 \| ATXN3 \| DISEASES 8301 \| PICALM \| DISEASES 10840 \| ALDH1L1 \| DISEASES 2596 \| GAP43 \| DISEASES 90102 \| PHLDB2 \| DISEASES 2719 \| GPC3 \| DISEASES 51520 \| LARS \| DISEASES 9560 \| CCL4L2 \| DISEASES 5530 \| PPP3CA \| DISEASES 64115 \| C10orf54 \| DISEASES 6696 \| SPP1 \| DISEASES 51142 \| CHCHD2 \| DISEASES 6387 \| CXCL12 \| DISEASES 2737 \| GLI3 \| DISEASES 54664 \| TMEM106B \| DISEASES 4780 \| NFE2L2 \| DISEASES 23426 \| GRIP1 \| DISEASES 594857 \| NPS \| DISEASES 55063 \| ZCWPW1 \| DISEASES 4905 \| NSF \| DISEASES 6314 \| ATXN7 \| DISEASES 1859 \| DYRK1A \| DISEASES 51451 \| LCMT1 \| DISEASES 54039 \| PCBP3 \| DISEASES 1826 \| DSCAM \| DISEASES 155184 \| SLC2A7 \| DISEASES 9718 \| ECE2 \| DISEASES 2825 \| GPR1 \| DISEASES 7122 \| CLDN5 \| DISEASES 728441 \| GGT2 \| DISEASES 7018 \| TF \| DISEASES 152 \| ADRA2C \| DISEASES 29072 \| SETD2 \| DISEASES 7852 \| CXCR4 \| DISEASES 501 \| ALDH7A1 \| DISEASES 26058 \| GIGYF2 \| DISEASES 3267 \| AGFG1 \| DISEASES 1385 \| CREB1 \| DISEASES 7311 \| UBA52 \| DISEASES 11277 \| TREX1 \| DISEASES 3481 \| IGF2 \| DISEASES 55707 \| NECAP2 \| DISEASES 5649 \| RELN \| DISEASES 146713 \| RBFOX3 \| DISEASES 5538 \| PPT1 \| DISEASES 10163 \| WASF2 \| DISEASES 154881 \| KCTD7 \| DISEASES 7124 \| TNF \| DISEASES 93649 \| MYOCD \| DISEASES 5817 \| PVR \| DISEASES 64084 \| CLSTN2 \| DISEASES 10715 \| CERS1 \| DISEASES 388372 \| CCL4L1 \| DISEASES 5424 \| POLD1 \| DISEASES 2876 \| GPX1 \| DISEASES 1139 \| CHRNA7 \| DISEASES 3920 \| LAMP2 \| DISEASES 2668 \| GDNF \| DISEASES 8867 \| SYNJ1 \| DISEASES 2632 \| GBE1 \| DISEASES 116 \| ADCYAP1 \| DISEASES 3586 \| IL10 \| DISEASES 54973 \| CPSF3L \| DISEASES 627 \| BDNF \| DISEASES 284716 \| RIMKLA \| DISEASES 643680 \| MS4A4E \| DISEASES 721 \| C4B \| DISEASES 629 \| CFB \| DISEASES 91647 \| ATPAF2 \| DISEASES 10243 \| GPHN \| DISEASES 3712 \| IVD \| DISEASES 400916 \| CHCHD10 \| DISEASES 1020 \| CDK5 \| DISEASES 30816 \| ERVW-1 \| DISEASES 58494 \| JAM2 \| DISEASES 7511 \| XPNPEP1 \| DISEASES 6949 \| TCOF1 \| DISEASES 51428 \| DDX41 \| DISEASES 493869 \| GPX8 \| DISEASES 91289 \| LMF2 \| DISEASES 65983 \| GRAMD3 \| DISEASES 285672 \| SREK1IP1 \| DISEASES 23286 \| WWC1 \| DISEASES 10687 \| PNMA2 \| DISEASES 3620 \| IDO1 \| DISEASES 4914 \| NTRK1 \| DISEASES 123041 \| SLC24A4 \| DISEASES 56 \| ACRV1 \| DISEASES 1232 \| CCR3 \| DISEASES 3684 \| ITGAM \| DISEASES 246744 \| STH \| DISEASES 4850 \| CNOT4 \| DISEASES 5125 \| PCSK5 \| DISEASES 7421 \| VDR \| DISEASES 8972 \| MGAM \| DISEASES 10059 \| DNM1L \| DISEASES 90799 \| CEP95 \| DISEASES 56342 \| PPAN \| DISEASES 10577 \| NPC2 \| DISEASES 51465 \| UBE2J1 \| DISEASES 567 \| B2M \| DISEASES 3949 \| LDLR \| DISEASES 91056 \| AP5B1 \| DISEASES 3316 \| HSPB2 \| DISEASES 353299 \| RGSL1 \| DISEASES 104355217 \| ERICD \| DISEASES 102191832 \| FBXW7-AS1 \| DISEASES 101927347 \| GRM7-AS3 \| DISEASES 101515984 \| LINC01080 \| DISEASES 4566 \| MT-TK \| DISEASES 4567 \| MT-TL1 \| DISEASES 677777 \| SCARNA12 \| DISEASES
Locus	(Waiting for update.)

Disease ID	735
Disease	dementia
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:198) HP:0100315 \| Lewy bodies \| 1100 HP:0100543 \| Cognitive deficits \| 152 HP:0001300 \| Parkinsonism \| 151 HP:0000716 \| Depression \| 129 HP:0001268 \| Mental deterioration \| 56 HP:0001297 \| Cerebral vascular events \| 53 HP:0012531 \| Pain \| 53 HP:0000713 \| Agitation \| 44 HP:0002354 \| Memory loss \| 34 HP:0000708 \| Behavioral problems \| 33 HP:0007354 \| Amyotrophic lateral sclerosis \| 29 HP:0000739 \| Anxiety \| 27 HP:0000819 \| Diabetes mellitus \| 24 HP:0003198 \| Myopathic changes \| 23 HP:0000709 \| Psychosis \| 22 HP:0002511 \| Late-onset form of familial Alzheimer disease \| 22 HP:0000741 \| Apathy \| 17 HP:0007302 \| Bipolar disorder \| 15 HP:0000718 \| Aggressive behaviour \| 14 HP:0002180 \| Neurodegeneration \| 14 HP:0001250 \| Seizures \| 11 HP:0000822 \| Hypertension \| 10 HP:0002360 \| Sleep disturbance \| 10 HP:0000738 \| Sensory hallucination \| 10 HP:0001824 \| Weight loss \| 9 HP:0001251 \| Ataxia \| 8 HP:0002527 \| Falls \| 8 HP:0002015 \| Swallowing difficulty \| 8 HP:0001513 \| Obesity \| 8 HP:0002090 \| Pneumonia \| 8 HP:0001336 \| Myoclonic jerks \| 8 HP:0002145 \| Frontotemporal dementia \| 8 HP:0000746 \| Delusions \| 7 HP:0001298 \| Encephalopathy \| 6 HP:0002120 \| Cerebral cortical atrophy \| 6 HP:0001903 \| Anemia \| 6 HP:0001289 \| Confusion \| 6 HP:0001249 \| Mental retardation \| 6 HP:0002529 \| Neuronal loss in central nervous system \| 6 HP:0000238 \| Nonsyndromal hydrocephalus \| 5 HP:0002381 \| Aphasia \| 5 HP:0005110 \| Atrial fibrillation \| 5 HP:0001288 \| Gait disturbance \| 5 HP:0012444 \| Brain wasting \| 5 HP:0011970 \| Cerebral amyloid angiopathy \| 5 HP:0100022 \| Movement disorder \| 5 HP:0000020 \| Bladder incontinence \| 5 HP:0002367 \| Visual hallucinations \| 5 HP:0002185 \| Paired helical filaments \| 5 HP:0000734 \| Disinhibition \| 4 HP:0000083 \| Renal insufficiency \| 4 HP:0001943 \| Hypoglycemia \| 4 HP:0012062 \| Bone cysts \| 4 HP:0012622 \| Chronic kidney disease \| 4 HP:0002621 \| Atherosclerosis \| 4 HP:0004395 \| Malnutrition \| 4 HP:0001635 \| Congestive heart failure \| 4 HP:0001337 \| Tremor \| 4 HP:0002071 \| Extrapyramidal dysfunction \| 4 HP:0002352 \| Leukoencephalopathy \| 4 HP:0100785 \| Insomnia \| 4 HP:0003077 \| Hyperlipidemia \| 3 HP:0100033 \| Tic disorder \| 3 HP:0000763 \| Sensory neuropathy \| 3 HP:0002186 \| Apraxia \| 3 HP:0003074 \| High blood glucose \| 3 HP:0002104 \| Absence of spontaneous respiration \| 3 HP:0000821 \| Underactive thyroid \| 3 HP:0010535 \| Sleep apnea \| 3 HP:0010522 \| Dyslexia \| 3 HP:0002343 \| Normal-pressure hydrocephalus \| 3 HP:0004947 \| Arteriovenous fistula \| 3 HP:0100753 \| Schizophrenia \| 3 HP:0002665 \| Lymphoma \| 3 HP:0002459 \| Dysautonomia \| 2 HP:0000505 \| Poor vision \| 2 HP:0011968 \| Feeding difficulties \| 2 HP:0000939 \| Osteoporosis \| 2 HP:0001658 \| Myocardial infarction \| 2 HP:0002300 \| Muteness \| 2 HP:0003002 \| Breast carcinoma \| 2 HP:0001269 \| Hemiparesis \| 2 HP:0003474 \| Sensory impairment \| 2 HP:0003124 \| Elevated serum cholesterol \| 2 HP:0002315 \| Headaches \| 2 HP:0002059 \| Degeneration of cerebrum \| 2 HP:0002326 \| TIA \| 2 HP:0000855 \| Insulin resistance \| 2 HP:0100512 \| Vitamin D deficiency \| 2 HP:0002140 \| Ischemic stroke \| 2 HP:0100256 \| Neuritic plaques \| 2 HP:0003774 \| End-stage renal failure \| 2 HP:0000365 \| Hearing impairment \| 2 HP:0000836 \| Overactive thyroid \| 2 HP:0012672 \| Akinetic mutism \| 2 HP:0030892 \| DWMH \| 2 HP:0100754 \| Mania \| 2 HP:0030186 \| Essential tremor \| 2 HP:0000802 \| Erectile dysfunction \| 2 HP:0000751 \| Personality changes \| 2 HP:0000711 \| Restlessness \| 2 HP:0001287 \| Meningitis \| 2 HP:0001508 \| Weight faltering \| 2 HP:0005202 \| Helicobacter pylori infection \| 2 HP:0002463 \| Language impairment \| 2 HP:0000737 \| Irritability \| 2 HP:0011034 \| Amyloid disease \| 1 HP:0002172 \| Postural instability \| 1 HP:0012378 \| Fatigue \| 1 HP:0001259 \| Coma \| 1 HP:0007256 \| Abnormal pyramidal signs \| 1 HP:0007123 \| Subcortical dementia \| 1 HP:0011947 \| Respiratory infection \| 1 HP:0030692 \| Brain tumor \| 1 HP:0000360 \| Ringing in the ears \| 1 HP:0012627 \| Pseudoexfoliation \| 1 HP:0002305 \| Involuntary writhing movements \| 1 HP:0001283 \| Bulbar palsies \| 1 HP:0002902 \| Hyponatremia \| 1 HP:0001272 \| Cerebellar atrophy \| 1 HP:0002608 \| Celiac disease \| 1 HP:0100545 \| Arterial stenosis \| 1 HP:0011665 \| Takotsubo cardiomyopathy \| 1 HP:0002119 \| Ventricular dilatation \| 1 HP:0001944 \| Dehydration \| 1 HP:0000488 \| Noninflammatory retina disease \| 1 HP:0001369 \| Arthritis \| 1 HP:0000491 \| Corneal inflammation \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0007024 \| Pseudobulbar palsy \| 1 HP:0002597 \| Abnormality of blood vessels \| 1 HP:0001891 \| Iron-deficiency anemia \| 1 HP:0030357 \| Small cell lung carcinoma \| 1 HP:0100546 \| Narrowing of carotid artery \| 1 HP:0002353 \| Abnormal EEG \| 1 HP:0002014 \| Diarrhea \| 1 HP:0000726 \| Dementia \| 1 HP:0001997 \| Gout \| 1 HP:0006785 \| Limb-girdle muscular dystrophy \| 1 HP:0000752 \| Hyperactive behavior \| 1 HP:0000501 \| Glaucoma \| 1 HP:0002607 \| Anal incontinence \| 1 HP:0002637 \| Brain ischemia \| 1 HP:0011096 \| Demyelination \| 1 HP:0030069 \| Primary central nervous system lymphoma \| 1 HP:0006789 \| Mitochondrial encephalopathy \| 1 HP:0001271 \| Polyneuropathy \| 1 HP:0000147 \| Sclerocystic ovaries \| 1 HP:0002664 \| Neoplasia \| 1 HP:0002357 \| Dysphasia \| 1 HP:0000733 \| Repetitive movements \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0002028 \| Chronic diarrhea \| 1 HP:0002383 \| Encephalitis \| 1 HP:0002500 \| Leukoaraiosis \| 1 HP:0010550 \| Paraplegia \| 1 HP:0002835 \| Aspiration \| 1 HP:0000608 \| Macular degeneration \| 1 HP:0011675 \| Arrhythmias \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0004749 \| Atrial flutter \| 1 HP:0012167 \| Trichotillomania \| 1 HP:0007868 \| ARMD \| 1 HP:0001258 \| Spastic paraplegia, lower limb \| 1 HP:0001278 \| Orthostatic hypotension \| 1 HP:0001260 \| Dysarthric speech \| 1 HP:0002591 \| Voracious appetite \| 1 HP:0002366 \| Lower motor neuron disease \| 1 HP:0001907 \| Thromboembolic disease \| 1 HP:0003560 \| Muscular dystrophy \| 1 HP:0001264 \| Spastic diplegia \| 1 HP:0001332 \| Dystonia \| 1 HP:0001257 \| Spasticity \| 1 HP:0002135 \| Basal ganglia calcification \| 1 HP:0000648 \| Optic-nerve degeneration \| 1 HP:0001262 \| Somnolence \| 1 HP:0010780 \| Hyperacusis \| 1 HP:0001324 \| Muscular weakness \| 1 HP:0007185 \| Loss of consciousness \| 1 HP:0012399 \| Bedsore \| 1 HP:0004324 \| Increased body weight \| 1 HP:0002013 \| Emesis \| 1 HP:0100710 \| Impulsivity \| 1 HP:0030213 \| Emotional blunting \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0030784 \| Anomic aphasia \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0006510 \| Chronic obstructive pulmonary disease \| 1 HP:0005952 \| Decreased lung function \| 1 HP:0030078 \| Lung adenocarcinoma \| 1 HP:0001575 \| Mood alterations \| 1 HP:0030223 \| Perseveration \| 1 HP:0002197 \| Generalized seizures \| 1 HP:0006765 \| Chondrosarcoma \| 1 HP:0001254 \| Lethargy \| 1 HP:0002385 \| Paraparesis \| 1 HP:0100806 \| Sepsis \| 1 HP:0002371 \| Loss of speech \| 1

Disease ID	735
Disease	dementia
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:97) C0242422 \| parkinsonism \| 151 C0011570 \| depression \| 129 C0030567 \| parkinson's disease \| 78 C0030567 \| parkinson's \| 58 C0030193 \| pain \| 53 C0038454 \| stroke \| 53 C0233401 \| psychiatric symptoms \| 47 C0085631 \| agitation \| 43 C0002736 \| amyotrophic lateral sclerosis \| 29 C0011206 \| delirium \| 28 C0233397 \| psychological symptoms \| 28 C0003467 \| anxiety \| 27 C0086132 \| depressive symptoms \| 26 C0042373 \| vascular disease \| 25 C0524851 \| neurodegenerative disease \| 24 C0026848 \| myopathy \| 23 C1839611 \| n syndrome \| 23 C0033975 \| psychosis \| 22 C0002395 \| alzheimer disease \| 22 C0524851 \| neurodegenerative disorder \| 20 C0002622 \| memory loss \| 19 C0085632 \| apathy \| 17 C0004941 \| behavioral symptom \| 15 C0021167 \| incontinence \| 13 C0752347 \| lewy body disease \| 12 C0679466 \| cognitive deficits \| 12 C0018524 \| hallucinations \| 10 C0036572 \| seizures \| 10 C0085084 \| motor neuron disease \| 9 C0231303 \| distress \| 9 C0037317 \| sleep disturbance \| 9 C0027066 \| myoclonus \| 8 C0032285 \| pneumonia \| 8 C0009241 \| cognitive disorders \| 8 C0004134 \| ataxia \| 8 C0851578 \| sleep disorders \| 7 C0871189 \| psychotic symptoms \| 7 C0011168 \| dysphagia \| 7 C0007222 \| cardiovascular disease \| 7 C0004941 \| behavioral symptoms \| 7 C0014544 \| epilepsy \| 6 C0042024 \| urinary incontinence \| 5 C0233763 \| visual hallucinations \| 5 C0525041 \| cognitive symptoms \| 5 C0700201 \| sleep problem \| 5 C0235946 \| brain atrophy \| 5 C0020255 \| hydrocephalus \| 5 C0085220 \| cerebral amyloid angiopathy \| 5 C0524851 \| neurodegenerative diseases \| 5 C0026636 \| oral disorder \| 4 C0021308 \| infarction \| 4 C0085631 \| agitated behavior \| 4 C2220255 \| motor disturbances \| 3 C0085631 \| agitated behaviour \| 3 C0234507 \| anosognosia \| 3 C0025261 \| memory disorder \| 3 C0422833 \| ent symptoms \| 3 C0027765 \| neurological disorders \| 3 C1504404 \| hippocampal sclerosis \| 3 C0041696 \| major depression \| 3 C0003635 \| apraxia \| 3 C1998045 \| subclinical hyperthyroidism \| 3 C0022336 \| creutzfeldt-jakob disease \| 3 C0524851 \| neurodegenerative disorders \| 3 C0007758 \| cerebellar ataxia \| 2 C0575081 \| gait disturbances \| 2 C0007398 \| catatonia \| 2 C0262405 \| brain dysfunction \| 2 C0235946 \| cerebral atrophy \| 2 C0085631 \| restlessness \| 2 C0796095 \| c syndrome \| 2 C0018681 \| headache \| 2 C0751230 \| hypothalamic dysfunction \| 1 C0268381 \| al amyloidosis \| 1 C0155765 \| microangiopathy \| 1 C0029166 \| oral manifestations \| 1 C0233777 \| hallucinosis \| 1 C0023015 \| language disorder \| 1 C0006111 \| brain diseases \| 1 C0006895 \| capgras syndrome \| 1 C0162534 \| prion diseases \| 1 C0007785 \| cerebral infarct \| 1 C0029896 \| ent diseases \| 1 C0020505 \| hyperphagia \| 1 C0037317 \| sleep disturbances \| 1 C0751772 \| rapid eye movement sleep behavior disorder \| 1 C0598608 \| hyperhomocysteinemia \| 1 C0522224 \| palsy \| 1 C0007820 \| cerebrovascular disorder \| 1 C0086132 \| symptoms of depression \| 1 C0240735 \| personality changes \| 1 C0234527 \| motor apraxia \| 1 C0813142 \| circadian rhythm disorders \| 1 C0011175 \| dehydration \| 1 C1446648 \| brain syndrome \| 1 C0240735 \| personality change \| 1 C2232697 \| mood symptoms \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:181)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1010159	19368828	6653	SORL1	umls:C0497327	BeFree	In the present study we investigated the association of SORL1 gene variants (rs2070045 (SNP19), SORL1-18ex26 (SNP21), rs3824968 (SNP23), rs1010159 (SNP25)) with AD risk by using Cox proportional hazard model and Kaplan-Meier survival analysis in 349 AD patients and 483 controls, recruited from a multicenter study of the German Competence Network Dementias.	0.000542884	2009	SORL1	11	121612692	C	T
rs1044396	22008229	1137	CHRNA4	umls:C0011265	BeFree	To determine the link between CHRNA4 variation and cognitive function/depressed mood, this study conducted a genotype-phenotype correlation analysis between the common CHRNA4:rs1044396 variant and several baseline parameters of cognition and depressed mood in 192 elderly male subjects without major psychiatric disorders or dementia.	0.000814326	2012	CHRNA4	20	63349782	G	C,A
rs1044396	22008229	1137	CHRNA4	umls:C0497327	BeFree	To determine the link between CHRNA4 variation and cognitive function/depressed mood, this study conducted a genotype-phenotype correlation analysis between the common CHRNA4:rs1044396 variant and several baseline parameters of cognition and depressed mood in 192 elderly male subjects without major psychiatric disorders or dementia.	0.006263026	2012	CHRNA4	20	63349782	G	C,A
rs121909329	23349634	7415	VCP	umls:C0011265	BeFree	This stimulatory effect was lost when we used VCP mutants (R155H, R159G, and R191Q) known to cause Inclusion Body Myopathy with Paget's disease of bone and Fronto-temporal Dementia (IBMPFD) and/or familial Amyotrophic Lateral Sclerosis (ALS).	0.005157396	2013	VCP	9	35065363	C	T,G
rs121909329	23349634	7415	VCP	umls:C0497327	BeFree	This stimulatory effect was lost when we used VCP mutants (R155H, R159G, and R191Q) known to cause Inclusion Body Myopathy with Paget's disease of bone and Fronto-temporal Dementia (IBMPFD) and/or familial Amyotrophic Lateral Sclerosis (ALS).	0.016054797	2013	VCP	9	35065363	C	T,G
rs121909330	17763460	7415	VCP	umls:C0497327	BeFree	We identified the p.R155C missense mutation in the VCP gene segregating in an Italian family with three affected siblings, two of whom had a progressive myopathy associated with dementia, whereas one exhibited a progressive myopathy and preclinical signs of Paget's disease of bone.	0.016054797	2008	VCP	9	35065364	G	A
rs121909330	17763460	7415	VCP	umls:C0011265	BeFree	We identified the p.R155C missense mutation in the VCP gene segregating in an Italian family with three affected siblings, two of whom had a progressive myopathy associated with dementia, whereas one exhibited a progressive myopathy and preclinical signs of Paget's disease of bone.	0.005157396	2008	VCP	9	35065364	G	A
rs121909334	23349634	7415	VCP	umls:C0497327	BeFree	This stimulatory effect was lost when we used VCP mutants (R155H, R159G, and R191Q) known to cause Inclusion Body Myopathy with Paget's disease of bone and Fronto-temporal Dementia (IBMPFD) and/or familial Amyotrophic Lateral Sclerosis (ALS).	0.016054797	2013	VCP	9	35065255	C	T
rs121909334	23349634	7415	VCP	umls:C0011265	BeFree	This stimulatory effect was lost when we used VCP mutants (R155H, R159G, and R191Q) known to cause Inclusion Body Myopathy with Paget's disease of bone and Fronto-temporal Dementia (IBMPFD) and/or familial Amyotrophic Lateral Sclerosis (ALS).	0.005157396	2013	VCP	9	35065255	C	T
rs121909335	16247064	7415	VCP	umls:C0011265	BeFree	We identified a novel missense mutation in the VCP gene (R159H; 688G>A) segregating with this disease in an Austrian family of four affected siblings, who exhibited progressive proximal myopathy and Paget disease of the bone but without clinical signs of dementia.	0.005157396	2005	VCP	9	35065351	C	T
rs121909335	16247064	7415	VCP	umls:C0497327	BeFree	We identified a novel missense mutation in the VCP gene (R159H; 688G>A) segregating with this disease in an Austrian family of four affected siblings, who exhibited progressive proximal myopathy and Paget disease of the bone but without clinical signs of dementia.	0.016054797	2005	VCP	9	35065351	C	T
rs121912438	20732897	6647	SOD1	umls:C0011265	BeFree	We suggest that the progressive disruption of M1 corticocortical connections resulting from the SOD1(G93A) mutation might extend to adjacent regions and promote development of cognitive/dementia alterations frequently associated with ALS.	0.002171535	2011	SOD1	21	31667299	G	C
rs121912438	20732897	6647	SOD1	umls:C0497327	BeFree	We suggest that the progressive disruption of M1 corticocortical connections resulting from the SOD1(G93A) mutation might extend to adjacent regions and promote development of cognitive/dementia alterations frequently associated with ALS.	0.004538567	2011	SOD1	21	31667299	G	C
rs12604324	25188341	114876	OSBPL1A	umls:C0497327	GWASCAT	Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.	0.12	2014	OSBPL1A	18	24164468	G	A
rs137852642	16877080	4854	NOTCH3	umls:C0011265	BeFree	Thirty-eight CADASIL patients (19 to 61 years old; 20 in a prestroke group, 15 in a stroke group, and 3 in a dementia group), all with the R133C NOTCH3 mutation and including one homozygous patient, underwent a detailed ophthalmologic examination.	0.004885954	2006	NOTCH3	19	15192242	G	T,A
rs137852642	16877080	4854	NOTCH3	umls:C0497327	BeFree	Thirty-eight CADASIL patients (19 to 61 years old; 20 in a prestroke group, 15 in a stroke group, and 3 in a dementia group), all with the R133C NOTCH3 mutation and including one homozygous patient, underwent a detailed ophthalmologic examination.	0.004885954	2006	NOTCH3	19	15192242	G	T,A
rs142690225	18727676	5664	PSEN2	umls:C0011265	BeFree	A novel presenilin 2 mutation (V393M) in early-onset dementia with profound language impairment.	0.003528744	2008	PSEN2	1	226894111	G	A
rs142690225	18727676	5664	PSEN2	umls:C0497327	BeFree	A novel presenilin 2 mutation (V393M) in early-onset dementia with profound language impairment.	0.008620127	2008	PSEN2	1	226894111	G	A
rs1741309	25188341	54498	SMOX	umls:C0497327	GWASCAT	Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.	0.12	2014	SMOX	20	4163930	A	G
rs17571	23415546	5663	PSEN1	umls:C0011265	BeFree	Involvement of cerebellar and brainstem structures leading to functional decortication in addition to rapid progressive presenile dementia in this PSEN1 family may therefore indicate an epistatic effect of the p.A58V Cathepsin D variant on the deleterious course of this disease.	0.012486326	2013	CTSD	11	1761364	G	A
rs1799983	20691505	342977	NANOS3	umls:C0011265	BeFree	NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors.	0.000542884	2011	NOS3	7	150999023	T	G
rs1799983	20691505	342977	NANOS3	umls:C0497327	BeFree	NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors.	0.000542884	2011	NOS3	7	150999023	T	G
rs1800587	24103372	3552	IL1A	umls:C0497327	BeFree	Interleukin-1 alpha (rs1800587) genetic polymorphism is associated with specific cognitive functions but not depression or loneliness in elderly males without dementia.	0.004538567	2013	IL1A	2	112785383	G	C,A
rs1800587	24103372	3552	IL1A	umls:C0011265	BeFree	Interleukin-1 alpha (rs1800587) genetic polymorphism is associated with specific cognitive functions but not depression or loneliness in elderly males without dementia.	0.002171535	2013	IL1A	2	112785383	G	C,A
rs1801132	23567436	1109	AKR1C4	umls:C0497327	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.003257302	2012	ESR1	6	151944387	G	C
rs1801132	23567436	2099	ESR1	umls:C0497327	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.011639663	2012	ESR1	6	151944387	G	C
rs1801132	23567436	2099	ESR1	umls:C0011265	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.002171535	2012	ESR1	6	151944387	G	C
rs1801132	23567436	1109	AKR1C4	umls:C0011265	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.003257302	2012	ESR1	6	151944387	G	C
rs1801282	21970714	5468	PPARG	umls:C0011265	BeFree	We also investigated the possible association between PPARgamma Pro12Ala polymorphism and dementia or 24S-OH-Chol levels.	0.000542884	2011	PPARG	3	12351626	C	G
rs1801282	21970714	5468	PPARG	umls:C0497327	BeFree	We also investigated the possible association between PPARgamma Pro12Ala polymorphism and dementia or 24S-OH-Chol levels.	0.005276948	2011	PPARG	3	12351626	C	G
rs1805054	11725820	3356	HTR2A	umls:C0497327	BeFree	In order to identify gene variants related to the serotonergic neurotransmitter system that possibly represent a hereditary risk factor for sporadic Alzheimer's disease (AD), patients suffering from AD and non-demented psychiatric inpatients without symptoms of dementia were genotyped for polymorphisms of HTR6 (267C/T) and HTR2A (-1438G/A).	0.000814326	2001	HTR6	1	19666020	C	T
rs1805054	11725820	3356	HTR2A	umls:C0011265	BeFree	In order to identify gene variants related to the serotonergic neurotransmitter system that possibly represent a hereditary risk factor for sporadic Alzheimer's disease (AD), patients suffering from AD and non-demented psychiatric inpatients without symptoms of dementia were genotyped for polymorphisms of HTR6 (267C/T) and HTR2A (-1438G/A).	0.000814326	2001	HTR6	1	19666020	C	T
rs1805054	11725820	3362	HTR6	umls:C0011265	BeFree	In order to identify gene variants related to the serotonergic neurotransmitter system that possibly represent a hereditary risk factor for sporadic Alzheimer's disease (AD), patients suffering from AD and non-demented psychiatric inpatients without symptoms of dementia were genotyped for polymorphisms of HTR6 (267C/T) and HTR2A (-1438G/A).	0.000542884	2001	HTR6	1	19666020	C	T
rs1805054	11725820	3362	HTR6	umls:C0497327	BeFree	In order to identify gene variants related to the serotonergic neurotransmitter system that possibly represent a hereditary risk factor for sporadic Alzheimer's disease (AD), patients suffering from AD and non-demented psychiatric inpatients without symptoms of dementia were genotyped for polymorphisms of HTR6 (267C/T) and HTR2A (-1438G/A).	0.000542884	2001	HTR6	1	19666020	C	T
rs1805192	21970714	5468	PPARG	umls:C0497327	BeFree	We also investigated the possible association between PPARgamma Pro12Ala polymorphism and dementia or 24S-OH-Chol levels.	0.005276948	2011	PPARG	3	12379739	C	G
rs1805192	21970714	5468	PPARG	umls:C0011265	BeFree	We also investigated the possible association between PPARgamma Pro12Ala polymorphism and dementia or 24S-OH-Chol levels.	0.000542884	2011	PPARG	3	12379739	C	G
rs1884049	23567436	1109	AKR1C4	umls:C0011265	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.003257302	2012	ESR1	6	151966232	T	C
rs1884049	23567436	1109	AKR1C4	umls:C0497327	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.003257302	2012	ESR1	6	151966232	T	C
rs1884049	23567436	2099	ESR1	umls:C0497327	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.011639663	2012	ESR1	6	151966232	T	C
rs1884049	23567436	2099	ESR1	umls:C0011265	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.002171535	2012	ESR1	6	151966232	T	C
rs193922916	22727994	351	APP	umls:C0011265	BeFree	We found a novel APP mutation (A673V) in the homozygous state in a patient with early-onset AD-type dementia and in his younger sister showing initial signs of cognitive decline.	0.007057489	2012	APP	21	25897619	G	A
rs193922916	22727994	351	APP	umls:C0497327	BeFree	We found a novel APP mutation (A673V) in the homozygous state in a patient with early-onset AD-type dementia and in his younger sister showing initial signs of cognitive decline.	0.150676439	2012	APP	21	25897619	G	A
rs1997794	19468819	5173	PDYN	umls:C0497327	BeFree	Thus, we tested the effect of four SNPs (rs7272891, rs1997794, rs2235751 and rs910080) and the VNTR promoter polymorphism in the prodynorphin gene (PDYN) on episodic memory and verbal fluency in a large (n = 1619) sample of elderly people (mean age: 80 +/- 3.39 years; range 75-90 years) recruited through the German study on ageing, cognition and dementia in primary care patients (AgeCoDe).	0.000271442	2009	PDYN;LOC727993	20	1994212	T	C
rs1997794	19468819	5173	PDYN	umls:C0011265	BeFree	Thus, we tested the effect of four SNPs (rs7272891, rs1997794, rs2235751 and rs910080) and the VNTR promoter polymorphism in the prodynorphin gene (PDYN) on episodic memory and verbal fluency in a large (n = 1619) sample of elderly people (mean age: 80 +/- 3.39 years; range 75-90 years) recruited through the German study on ageing, cognition and dementia in primary care patients (AgeCoDe).	0.000271442	2009	PDYN;LOC727993	20	1994212	T	C
rs201106962	23457019	6622	SNCA	umls:C0011265	BeFree	Here, we describe a novel missense mutation in exon 4 of SNCA encoding a H50Q substitution in a patient with dopa-responsive Parkinson's disease with a family history of parkinsonism and dementia.	0.003528744	2013	SNCA	4	89828156	A	C
rs201106962	23457019	6622	SNCA	umls:C0497327	BeFree	Here, we describe a novel missense mutation in exon 4 of SNCA encoding a H50Q substitution in a patient with dopa-responsive Parkinson's disease with a family history of parkinsonism and dementia.	0.032696084	2013	SNCA	4	89828156	A	C
rs2070045	19368828	6653	SORL1	umls:C0497327	BeFree	In the present study we investigated the association of SORL1 gene variants (rs2070045 (SNP19), SORL1-18ex26 (SNP21), rs3824968 (SNP23), rs1010159 (SNP25)) with AD risk by using Cox proportional hazard model and Kaplan-Meier survival analysis in 349 AD patients and 483 controls, recruited from a multicenter study of the German Competence Network Dementias.	0.000542884	2009	SORL1	11	121577381	T	G
rs2234693	23491264	2100	ESR2	umls:C0497327	BeFree	Although there was only weak support for a gender-specific association between the common ESR1rs2234693 polymorphism and AD, this polymorphism may act as an effect modifier, modifying the association between an ESR2 polymorphism and dementia, as well as the risk of AD associated with the APOE ε4 allele.	0.000271442	2012	ESR1	6	151842200	T	C
rs2234693	23491264	2100	ESR2	umls:C0011265	BeFree	Although there was only weak support for a gender-specific association between the common ESR1rs2234693 polymorphism and AD, this polymorphism may act as an effect modifier, modifying the association between an ESR2 polymorphism and dementia, as well as the risk of AD associated with the APOE ε4 allele.	0.000271442	2012	ESR1	6	151842200	T	C
rs2234693	23491264	348	APOE	umls:C0497327	BeFree	Although there was only weak support for a gender-specific association between the common ESR1rs2234693 polymorphism and AD, this polymorphism may act as an effect modifier, modifying the association between an ESR2 polymorphism and dementia, as well as the risk of AD associated with the APOE ε4 allele.	0.228108756	2012	ESR1	6	151842200	T	C
rs2234693	23491264	348	APOE	umls:C0011265	BeFree	Although there was only weak support for a gender-specific association between the common ESR1rs2234693 polymorphism and AD, this polymorphism may act as an effect modifier, modifying the association between an ESR2 polymorphism and dementia, as well as the risk of AD associated with the APOE ε4 allele.	0.08	2012	ESR1	6	151842200	T	C
rs2235751	19468819	5173	PDYN	umls:C0011265	BeFree	Thus, we tested the effect of four SNPs (rs7272891, rs1997794, rs2235751 and rs910080) and the VNTR promoter polymorphism in the prodynorphin gene (PDYN) on episodic memory and verbal fluency in a large (n = 1619) sample of elderly people (mean age: 80 +/- 3.39 years; range 75-90 years) recruited through the German study on ageing, cognition and dementia in primary care patients (AgeCoDe).	0.000271442	2009	PDYN;LOC727993	20	1989288	A	G
rs2235751	19468819	5173	PDYN	umls:C0497327	BeFree	Thus, we tested the effect of four SNPs (rs7272891, rs1997794, rs2235751 and rs910080) and the VNTR promoter polymorphism in the prodynorphin gene (PDYN) on episodic memory and verbal fluency in a large (n = 1619) sample of elderly people (mean age: 80 +/- 3.39 years; range 75-90 years) recruited through the German study on ageing, cognition and dementia in primary care patients (AgeCoDe).	0.000271442	2009	PDYN;LOC727993	20	1989288	A	G
rs267606673	22210628	7415	VCP	umls:C0011265	BeFree	Immunoprecipitation assays revealed an abnormal interaction between ATP7A(T994I) and p97/VCP, an ubiquitin-selective chaperone which is mutated in two autosomal dominant forms of motor neuron disease: amyotrophic lateral sclerosis and inclusion body myopathy with early-onset Paget disease and fronto-temporal dementia.	0.005157396	2012	ATP7A	X	78029314	C	T
rs267606673	22210628	538	ATP7A	umls:C0497327	BeFree	Immunoprecipitation assays revealed an abnormal interaction between ATP7A(T994I) and p97/VCP, an ubiquitin-selective chaperone which is mutated in two autosomal dominant forms of motor neuron disease: amyotrophic lateral sclerosis and inclusion body myopathy with early-onset Paget disease and fronto-temporal dementia.	0.000271442	2012	ATP7A	X	78029314	C	T
rs267606673	22210628	7415	VCP	umls:C0497327	BeFree	Immunoprecipitation assays revealed an abnormal interaction between ATP7A(T994I) and p97/VCP, an ubiquitin-selective chaperone which is mutated in two autosomal dominant forms of motor neuron disease: amyotrophic lateral sclerosis and inclusion body myopathy with early-onset Paget disease and fronto-temporal dementia.	0.016054797	2012	ATP7A	X	78029314	C	T
rs267606673	22210628	538	ATP7A	umls:C0011265	BeFree	Immunoprecipitation assays revealed an abnormal interaction between ATP7A(T994I) and p97/VCP, an ubiquitin-selective chaperone which is mutated in two autosomal dominant forms of motor neuron disease: amyotrophic lateral sclerosis and inclusion body myopathy with early-onset Paget disease and fronto-temporal dementia.	0.000271442	2012	ATP7A	X	78029314	C	T
rs28936380	15755689	5664	PSEN2	umls:C0011265	BeFree	Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia.	0.003528744	2005	PSEN2	1	226885546	C	G,T
rs28936380	15755689	5664	PSEN2	umls:C0497327	BeFree	Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia.	0.008620127	2005	PSEN2	1	226885546	C	G,T
rs2986017	19191332	255022	CALHM1	umls:C0011265	BeFree	A non-synonymous polymorphism, rs2986017 (p.P86L), in the newly characterized calcium homeostasis modulator 1 (CALHM1) gene located in the Alzheimer dementia (AD) linkage region on 10q24.33, was reported to increase risk of AD, and affect calcium homeostasis and amyloid beta accumulation.	0.000271442	2009	CALHM1	10	103458495	A	G
rs2986017	19191332	255022	CALHM1	umls:C0497327	BeFree	A non-synonymous polymorphism, rs2986017 (p.P86L), in the newly characterized calcium homeostasis modulator 1 (CALHM1) gene located in the Alzheimer dementia (AD) linkage region on 10q24.33, was reported to increase risk of AD, and affect calcium homeostasis and amyloid beta accumulation.	0.000271442	2009	CALHM1	10	103458495	A	G
rs33939927	25127457	120892	LRRK2	umls:C0011265	BeFree	In conclusion, significant differences were not detected between R1441G-PD and i-PD in cognitive, depression and anxiety scales, or PD-MCI and PD-Dementia prevalence, and the cognitive profile was identical in the two groups.	0.001900093	2014	LRRK2	12	40310434	C	G,T
rs33939927	25127457	120892	LRRK2	umls:C0497327	BeFree	In conclusion, significant differences were not detected between R1441G-PD and i-PD in cognitive, depression and anxiety scales, or PD-MCI and PD-Dementia prevalence, and the cognitive profile was identical in the two groups.	0.007348794	2014	LRRK2	12	40310434	C	G,T
rs34637584	22194196	120892	LRRK2	umls:C0011265	BeFree	Larger longitudinal follow-up of LRRK2 G2019S mutation carriers is required to assess for risk factors for cortical involvement and dementia.	0.001900093	2012	LRRK2	12	40340400	G	A
rs34637584	22194196	120892	LRRK2	umls:C0497327	BeFree	Larger longitudinal follow-up of LRRK2 G2019S mutation carriers is required to assess for risk factors for cortical involvement and dementia.	0.007348794	2012	LRRK2	12	40340400	G	A
rs35801418	16865326	120892	LRRK2	umls:C0497327	BeFree	Pathogenic Lrrk2 Y1699C substitution observed in a large German-Canadian kindred presents a neurodegenerative disorder that is reminiscent of amyotrophic lateral sclerosis and Parkinsonism-Dementia Complex.	0.007348794	2007	LRRK2	12	40321114	A	G
rs35801418	16865326	120892	LRRK2	umls:C0011265	BeFree	Pathogenic Lrrk2 Y1699C substitution observed in a large German-Canadian kindred presents a neurodegenerative disorder that is reminiscent of amyotrophic lateral sclerosis and Parkinsonism-Dementia Complex.	0.001900093	2007	LRRK2	12	40321114	A	G
rs367543041	20697052	23435	TARDBP	umls:C0011265	BeFree	Amyotrophic lateral sclerosis-frontotemporal lobar dementia in 3 families with p.Ala382Thr TARDBP mutations.	0.003528744	2010	TARDBP	1	11022553	G	A,C
rs367543041	20697052	23435	TARDBP	umls:C0497327	BeFree	Amyotrophic lateral sclerosis-frontotemporal lobar dementia in 3 families with p.Ala382Thr TARDBP mutations.	0.017064619	2010	TARDBP	1	11022553	G	A,C
rs3824968	19368828	6653	SORL1	umls:C0497327	BeFree	In the present study we investigated the association of SORL1 gene variants (rs2070045 (SNP19), SORL1-18ex26 (SNP21), rs3824968 (SNP23), rs1010159 (SNP25)) with AD risk by using Cox proportional hazard model and Kaplan-Meier survival analysis in 349 AD patients and 483 controls, recruited from a multicenter study of the German Competence Network Dementias.	0.000542884	2009	SORL1	11	121605213	T	A
rs386602276	15000807	6532	SLC6A4	umls:C0497327	BeFree	The aim of this study was to investigate the association of a serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the 5-HT2A receptor T102C polymorphism with the risk of developing dementia and/or psychotic symptoms in a group of sporadic AD patients from Italy.	0.008815624	2003	NA	NA	NA	NA	NA
rs386602276	19910872	3356	HTR2A	umls:C0011265	BeFree	The strong and robust positive association that was noted between the C allele of HTR2A and psychosis suggests that the HTR2A T102C polymorphism is a significant risk factor for psychosis of AD.	0.000814326	2009	NA	NA	NA	NA	NA
rs386602276	15000807	3356	HTR2A	umls:C0497327	BeFree	The aim of this study was to investigate the association of a serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the 5-HT2A receptor T102C polymorphism with the risk of developing dementia and/or psychotic symptoms in a group of sporadic AD patients from Italy.	0.000814326	2003	NA	NA	NA	NA	NA
rs386602276	15000807	3356	HTR2A	umls:C0011265	BeFree	The aim of this study was to investigate the association of a serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the 5-HT2A receptor T102C polymorphism with the risk of developing dementia and/or psychotic symptoms in a group of sporadic AD patients from Italy.	0.000814326	2003	NA	NA	NA	NA	NA
rs386602276	15000807	6532	SLC6A4	umls:C0011265	BeFree	The aim of this study was to investigate the association of a serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the 5-HT2A receptor T102C polymorphism with the risk of developing dementia and/or psychotic symptoms in a group of sporadic AD patients from Italy.	0.001357209	2003	NA	NA	NA	NA	NA
rs386602276	19910872	3356	HTR2A	umls:C0497327	BeFree	The strong and robust positive association that was noted between the C allele of HTR2A and psychosis suggests that the HTR2A T102C polymorphism is a significant risk factor for psychosis of AD.	0.000814326	2009	NA	NA	NA	NA	NA
rs386747134	19191332	255022	CALHM1	umls:C0497327	BeFree	A non-synonymous polymorphism, rs2986017 (p.P86L), in the newly characterized calcium homeostasis modulator 1 (CALHM1) gene located in the Alzheimer dementia (AD) linkage region on 10q24.33, was reported to increase risk of AD, and affect calcium homeostasis and amyloid beta accumulation.	0.000271442	2009	NA	NA	NA	NA	NA
rs386747134	19191332	255022	CALHM1	umls:C0011265	BeFree	A non-synonymous polymorphism, rs2986017 (p.P86L), in the newly characterized calcium homeostasis modulator 1 (CALHM1) gene located in the Alzheimer dementia (AD) linkage region on 10q24.33, was reported to increase risk of AD, and affect calcium homeostasis and amyloid beta accumulation.	0.000271442	2009	NA	NA	NA	NA	NA
rs387906709	25246588	29978	UBQLN2	umls:C0011265	BeFree	Here, we show that ALS/dementia-linked UBQLN2(P497H) transgenic mice develop neuronal pathology with ubiquilin2/ubiquitin/p62-positive inclusions in the brain, especially in the hippocampus, recapitulating several key pathological features of dementia observed in human patients with UBQLN2 mutations.	0.001085767	2015	UBQLN2;LOC105377210	X	56565363	C	A,T
rs387906709	25246588	29978	UBQLN2	umls:C0497327	BeFree	Here, we show that ALS/dementia-linked UBQLN2(P497H) transgenic mice develop neuronal pathology with ubiquilin2/ubiquitin/p62-positive inclusions in the brain, especially in the hippocampus, recapitulating several key pathological features of dementia observed in human patients with UBQLN2 mutations.	0.001085767	2015	UBQLN2;LOC105377210	X	56565363	C	A,T
rs387906789	23349634	7415	VCP	umls:C0497327	BeFree	This stimulatory effect was lost when we used VCP mutants (R155H, R159G, and R191Q) known to cause Inclusion Body Myopathy with Paget's disease of bone and Fronto-temporal Dementia (IBMPFD) and/or familial Amyotrophic Lateral Sclerosis (ALS).	0.016054797	2013	VCP	9	35065352	G	C,A
rs387906789	23349634	7415	VCP	umls:C0011265	BeFree	This stimulatory effect was lost when we used VCP mutants (R155H, R159G, and R191Q) known to cause Inclusion Body Myopathy with Paget's disease of bone and Fronto-temporal Dementia (IBMPFD) and/or familial Amyotrophic Lateral Sclerosis (ALS).	0.005157396	2013	VCP	9	35065352	G	C,A
rs429358	20847432	3918	LAMC2	umls:C0497327	BeFree	When adjusted for CSF Aß42, the association of rs429358 with dementia is greatly reduced but remains significant indicating that APOE polymorphism influences disease by additional mechanisms distinct from Aß42 metabolism.	0.006786047	2010	APOE	19	44908684	T	C
rs429358	20847432	3918	LAMC2	umls:C0011265	BeFree	When adjusted for CSF Aß42, the association of rs429358 with dementia is greatly reduced but remains significant indicating that APOE polymorphism influences disease by additional mechanisms distinct from Aß42 metabolism.	0.005157396	2010	APOE	19	44908684	T	C
rs4680	23069674	1312	COMT	umls:C0497327	BeFree	No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias.	0.004267125	2012	COMT;MIR4761	22	19963748	G	A
rs4795541	19020798	6532	SLC6A4	umls:C0497327	GAD	[the rs4795541 might be important for FTLD susceptibility in the Italian population.]	0.008815624	2008	NA	NA	NA	NA	NA
rs4945261	18853460	348	APOE	umls:C0497327	BeFree	When assessing the effect of APOE and rs4945261 in one model, rs4945261 did not show a main effect, but the joint risk effect of rs4945261-GG and APOE epsilon4 on AD was significant (OR 3.87, 95%CI 2.66-5.63; p=1.0E-12), with a deviation of 1.87 from the multiplicative model of interaction.	0.228108756	2009	GAB2	11	78279214	G	A
rs4945261	18853460	348	APOE	umls:C0011265	BeFree	When assessing the effect of APOE and rs4945261 in one model, rs4945261 did not show a main effect, but the joint risk effect of rs4945261-GG and APOE epsilon4 on AD was significant (OR 3.87, 95%CI 2.66-5.63; p=1.0E-12), with a deviation of 1.87 from the multiplicative model of interaction.	0.08	2009	GAB2	11	78279214	G	A
rs5848	21047645	724029	MIR659	umls:C0497327	BeFree	This is consistent with the finding that miR-659 binding to the high risk T allele of rs5848 may augment translational inhibition of GRN and alter risk of FTD and possibly other dementias.	0.002995792	2011	GRN	17	44352876	C	T
rs5848	21047645	2896	GRN	umls:C0497327	BeFree	This is consistent with the finding that miR-659 binding to the high risk T allele of rs5848 may augment translational inhibition of GRN and alter risk of FTD and possibly other dementias.	0.194317412	2011	GRN	17	44352876	C	T
rs5882	22122979	1071	CETP	umls:C0497327	BeFree	Using data from two ongoing epidemiologic clinical-pathologic cohort studies of aging and dementia in the United States, the Religious Order Study and the Memory and Aging Project, we evaluated the association of the CETP I405V polymorphism (rs5882) with cognitive decline and risk of incident AD in more than 1300 participants of European ancestry.	0.010282454	2012	CETP	16	56982180	G	A
rs5882	22122979	1071	CETP	umls:C0011265	BeFree	Using data from two ongoing epidemiologic clinical-pathologic cohort studies of aging and dementia in the United States, the Religious Order Study and the Memory and Aging Project, we evaluated the association of the CETP I405V polymorphism (rs5882) with cognitive decline and risk of incident AD in more than 1300 participants of European ancestry.	0.000814326	2012	CETP	16	56982180	G	A
rs6313	15000807	3356	HTR2A	umls:C0497327	BeFree	The aim of this study was to investigate the association of a serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the 5-HT2A receptor T102C polymorphism with the risk of developing dementia and/or psychotic symptoms in a group of sporadic AD patients from Italy.	0.000814326	2003	HTR2A	13	46895805	G	A
rs6313	15000807	3356	HTR2A	umls:C0011265	BeFree	The aim of this study was to investigate the association of a serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the 5-HT2A receptor T102C polymorphism with the risk of developing dementia and/or psychotic symptoms in a group of sporadic AD patients from Italy.	0.000814326	2003	HTR2A	13	46895805	G	A
rs6313	15000807	6532	SLC6A4	umls:C0011265	BeFree	The aim of this study was to investigate the association of a serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the 5-HT2A receptor T102C polymorphism with the risk of developing dementia and/or psychotic symptoms in a group of sporadic AD patients from Italy.	0.001357209	2003	HTR2A	13	46895805	G	A
rs6313	15000807	6532	SLC6A4	umls:C0497327	BeFree	The aim of this study was to investigate the association of a serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the 5-HT2A receptor T102C polymorphism with the risk of developing dementia and/or psychotic symptoms in a group of sporadic AD patients from Italy.	0.008815624	2003	HTR2A	13	46895805	G	A
rs6313	19910872	3356	HTR2A	umls:C0497327	BeFree	The strong and robust positive association that was noted between the C allele of HTR2A and psychosis suggests that the HTR2A T102C polymorphism is a significant risk factor for psychosis of AD.	0.000814326	2009	HTR2A	13	46895805	G	A
rs6313	19910872	3356	HTR2A	umls:C0011265	BeFree	The strong and robust positive association that was noted between the C allele of HTR2A and psychosis suggests that the HTR2A T102C polymorphism is a significant risk factor for psychosis of AD.	0.000814326	2009	HTR2A	13	46895805	G	A
rs6330	22301435	345643	MCIDAS	umls:C0011265	BeFree	Among 200 outpatients with dementia and MCI whose NGF SNP rs6330 genotype was identified, those with A-MCI (n = 35) and early-stage AD (n = 67) were recruited and divided into three groups according to genotype (C/C: n = 58, C/T: n = 39, T/T: n = 5).	0.003528744	2011	NGF	1	115286692	G	A
rs6330	22301435	345643	MCIDAS	umls:C0497327	BeFree	Among 200 outpatients with dementia and MCI whose NGF SNP rs6330 genotype was identified, those with A-MCI (n = 35) and early-stage AD (n = 67) were recruited and divided into three groups according to genotype (C/C: n = 58, C/T: n = 39, T/T: n = 5).	0.003528744	2011	NGF	1	115286692	G	A
rs6332	23075484	345643	MCIDAS	umls:C0011265	BeFree	Among 215 outpatients with dementia and MCI, 155 with mild AD (n = 108) or A-MCI (n = 47) were recruited and divided into three genotypic groups based on the representative NT-3 functional polymorphisms rs6332 and rs6489630.	0.003528744	2012	NTF3	12	5494466	G	A,T
rs6332	23075484	345643	MCIDAS	umls:C0497327	BeFree	Among 215 outpatients with dementia and MCI, 155 with mild AD (n = 108) or A-MCI (n = 47) were recruited and divided into three genotypic groups based on the representative NT-3 functional polymorphisms rs6332 and rs6489630.	0.003528744	2012	NTF3	12	5494466	G	A,T
rs6347	23034259	6531	SLC6A3	umls:C0497327	BeFree	Moreover, a strong association was observed between the A allele at rs6347 of DAT1 and moderate stage of dementia.	0.120542884	2012	SLC6A3	5	1411297	T	C
rs6347	23034259	6531	SLC6A3	umls:C0011265	BeFree	Moreover, a strong association was observed between the A allele at rs6347 of DAT1 and moderate stage of dementia.	0.000542884	2012	SLC6A3	5	1411297	T	C
rs63749824	17615170	5663	PSEN1	umls:C0497327	BeFree	The A79V mutation in PS1 can be associated with very late onset of dementia.	0.046016599	2007	PSEN1	14	73170945	C	T
rs63749824	17615170	5663	PSEN1	umls:C0011265	BeFree	The A79V mutation in PS1 can be associated with very late onset of dementia.	0.012486326	2007	PSEN1	14	73170945	C	T
rs63749855	12876142	4137	MAPT	umls:C0011265	BeFree	Dementia in one or more first-degree family members was found in 43% of patients and mutation analysis of the tau gene showed mutations in 34 patients (19 P301L, five L315R, four G272V, four R406W, one Delta K280 and one S320F), all with a positive family history for dementia (14% of the total population, 32% of patients with a positive family history).	0.019272373	2003	MAPT	17	46014271	T	G
rs63749855	12876142	4137	MAPT	umls:C0497327	BeFree	Dementia in one or more first-degree family members was found in 43% of patients and mutation analysis of the tau gene showed mutations in 34 patients (19 P301L, five L315R, four G272V, four R406W, one Delta K280 and one S320F), all with a positive family history for dementia (14% of the total population, 32% of patients with a positive family history).	0.232545904	2003	MAPT	17	46014271	T	G
rs63750082	23114514	5663	PSEN1	umls:C0011265	BeFree	Frequency and clinicopathological characteristics of presenilin 1 Gly206Ala mutation in Puerto Rican Hispanics with dementia.	0.012486326	2013	PSEN1	14	73192712	G	C,T
rs63750082	23114514	5663	PSEN1	umls:C0497327	BeFree	Frequency and clinicopathological characteristics of presenilin 1 Gly206Ala mutation in Puerto Rican Hispanics with dementia.	0.046016599	2013	PSEN1	14	73192712	G	C,T
rs63750215	19073399	5664	PSEN2	umls:C0011265	BeFree	To our knowledge, this is the first German EOAD patient without a Volga-German ancestry and a positive family history for dementia carries the mutation PSEN-2 N141I.	0.003528744	2008	PSEN2	1	226885603	A	T
rs63750215	19073399	5664	PSEN2	umls:C0497327	BeFree	To our knowledge, this is the first German EOAD patient without a Volga-German ancestry and a positive family history for dementia carries the mutation PSEN-2 N141I.	0.008620127	2008	PSEN2	1	226885603	A	T
rs63750231	21296022	5663	PSEN1	umls:C0011265	BeFree	Pre-dementia clinical stages in presenilin 1 E280A familial early-onset Alzheimer's disease: a retrospective cohort study.	0.012486326	2011	PSEN1	14	73198100	A	C,G
rs63750231	21296022	5663	PSEN1	umls:C0497327	BeFree	Pre-dementia clinical stages in presenilin 1 E280A familial early-onset Alzheimer's disease: a retrospective cohort study.	0.046016599	2011	PSEN1	14	73198100	A	C,G
rs63750231	10923058	5663	PSEN1	umls:C0011265	BeFree	Participants with SAD met the criteria for dementia and were negative for the E280A presenilin 1 mutation.	0.012486326	2000	PSEN1	14	73198100	A	C,G
rs63750231	10923058	5663	PSEN1	umls:C0497327	BeFree	Participants with SAD met the criteria for dementia and were negative for the E280A presenilin 1 mutation.	0.046016599	2000	PSEN1	14	73198100	A	C,G
rs63750376	12876142	4137	MAPT	umls:C0011265	BeFree	Dementia in one or more first-degree family members was found in 43% of patients and mutation analysis of the tau gene showed mutations in 34 patients (19 P301L, five L315R, four G272V, four R406W, one Delta K280 and one S320F), all with a positive family history for dementia (14% of the total population, 32% of patients with a positive family history).	0.019272373	2003	MAPT	17	45996657	G	T
rs63750376	12876142	4137	MAPT	umls:C0497327	BeFree	Dementia in one or more first-degree family members was found in 43% of patients and mutation analysis of the tau gene showed mutations in 34 patients (19 P301L, five L315R, four G272V, four R406W, one Delta K280 and one S320F), all with a positive family history for dementia (14% of the total population, 32% of patients with a positive family history).	0.232545904	2003	MAPT	17	45996657	G	T
rs63750424	23727082	4137	MAPT	umls:C0011265	BeFree	The Arg406Trp (R406W) missense mutation in the microtubule-associated protein-tau gene (MAPT) is a known cause of early-onset dementia.	0.019272373	2013	MAPT	17	46024061	C	T
rs63750424	18284428	4137	MAPT	umls:C0497327	BeFree	We report clinical, molecular, neuroimaging and neuropathological features of a Danish family with autosomal dominant inherited dementia, a clinical phenotype resembling Alzheimer's disease and a pathogenic mutation (R406W) in the microtubule associated protein tau (MAPT) gene.	0.232545904	2008	MAPT	17	46024061	C	T
rs63750424	12876142	4137	MAPT	umls:C0497327	BeFree	Dementia in one or more first-degree family members was found in 43% of patients and mutation analysis of the tau gene showed mutations in 34 patients (19 P301L, five L315R, four G272V, four R406W, one Delta K280 and one S320F), all with a positive family history for dementia (14% of the total population, 32% of patients with a positive family history).	0.232545904	2003	MAPT	17	46024061	C	T
rs63750424	12876142	4137	MAPT	umls:C0011265	BeFree	Dementia in one or more first-degree family members was found in 43% of patients and mutation analysis of the tau gene showed mutations in 34 patients (19 P301L, five L315R, four G272V, four R406W, one Delta K280 and one S320F), all with a positive family history for dementia (14% of the total population, 32% of patients with a positive family history).	0.019272373	2003	MAPT	17	46024061	C	T
rs63750424	18284428	4137	MAPT	umls:C0011265	BeFree	We report clinical, molecular, neuroimaging and neuropathological features of a Danish family with autosomal dominant inherited dementia, a clinical phenotype resembling Alzheimer's disease and a pathogenic mutation (R406W) in the microtubule associated protein tau (MAPT) gene.	0.019272373	2008	MAPT	17	46024061	C	T
rs63750424	23727082	4137	MAPT	umls:C0497327	BeFree	The Arg406Trp (R406W) missense mutation in the microtubule-associated protein-tau gene (MAPT) is a known cause of early-onset dementia.	0.232545904	2013	MAPT	17	46024061	C	T
rs63750444	12111359	5663	PSEN1	umls:C0011265	BeFree	A novel mutation (G217D) in the Presenilin 1 gene ( PSEN1) in a Japanese family: presenile dementia and parkinsonism are associated with cotton wool plaques in the cortex and striatum.	0.012486326	2002	PSEN1	14	73192745	G	A
rs63750512	11193177	4137	MAPT	umls:C0011265	BeFree	The present findings indicate that the G389R mutation in Tau can cause a dementia similar to that in Pick's disease.	0.019272373	2000	MAPT	17	46024010	G	A,C
rs63750512	11193177	4137	MAPT	umls:C0497327	BeFree	The present findings indicate that the G389R mutation in Tau can cause a dementia similar to that in Pick's disease.	0.232545904	2000	MAPT	17	46024010	G	A,C
rs63750635	12876142	4137	MAPT	umls:C0011265	BeFree	Dementia in one or more first-degree family members was found in 43% of patients and mutation analysis of the tau gene showed mutations in 34 patients (19 P301L, five L315R, four G272V, four R406W, one Delta K280 and one S320F), all with a positive family history for dementia (14% of the total population, 32% of patients with a positive family history).	0.019272373	2003	MAPT	17	46014286	C	T
rs63750635	12876142	4137	MAPT	umls:C0497327	BeFree	Dementia in one or more first-degree family members was found in 43% of patients and mutation analysis of the tau gene showed mutations in 34 patients (19 P301L, five L315R, four G272V, four R406W, one Delta K280 and one S320F), all with a positive family history for dementia (14% of the total population, 32% of patients with a positive family history).	0.232545904	2003	MAPT	17	46014286	C	T
rs63750635	11891833	4137	MAPT	umls:C0011265	BeFree	In this article, we describe a novel missense mutation, S320F, in the tau gene in a family with presenile dementia.	0.019272373	2002	MAPT	17	46014286	C	T
rs63750680	15469450	5663	PSEN1	umls:C0011265	BeFree	New V272A presenilin 1 mutation with very early onset subcortical dementia and parkinsonism.	0.012486326	2004	PSEN1	14	73198076	T	C
rs63750680	15469450	5663	PSEN1	umls:C0497327	BeFree	New V272A presenilin 1 mutation with very early onset subcortical dementia and parkinsonism.	0.046016599	2004	PSEN1	14	73198076	T	C
rs63750756	10412802	4137	MAPT	umls:C0011265	BeFree	A mutation at codon 279 (N279K) in exon 10 of the Tau gene causes a tauopathy with dementia and supranuclear palsy.	0.019272373	1999	MAPT	17	46010324	T	G
rs63750756	10412802	4137	MAPT	umls:C0497327	BeFree	A mutation at codon 279 (N279K) in exon 10 of the Tau gene causes a tauopathy with dementia and supranuclear palsy.	0.232545904	1999	MAPT	17	46010324	T	G
rs63750756	12056930	4137	MAPT	umls:C0497327	BeFree	An N279K missense mutation in exon 10 of the tau gene reported in an American family with pallidopontonigral degeneration (PPND family) was recently found in members of a French kindred with dementia and supranuclear palsy.	0.232545904	2002	MAPT	17	46010324	T	G
rs63750756	12056930	4137	MAPT	umls:C0011265	BeFree	An N279K missense mutation in exon 10 of the tau gene reported in an American family with pallidopontonigral degeneration (PPND family) was recently found in members of a French kindred with dementia and supranuclear palsy.	0.019272373	2002	MAPT	17	46010324	T	G
rs63750802	22882713	5663	PSEN1	umls:C0497327	BeFree	We describe here clinical and neuropathological features of a patient with dementia-parkinsonism from a family with a PSEN1 mutation (L420R).	0.046016599	2014	PSEN1	14	73219144	T	G
rs63750802	22882713	5663	PSEN1	umls:C0011265	BeFree	We describe here clinical and neuropathological features of a patient with dementia-parkinsonism from a family with a PSEN1 mutation (L420R).	0.012486326	2014	PSEN1	14	73219144	T	G
rs63750959	11921059	4137	MAPT	umls:C0497327	BeFree	Thus, we consider that the Arg5His mutation is an authentic tau gene abnormality responsible for the patient's tau pathology and late-onset dementia.	0.232545904	2002	MAPT	17	45962351	G	A,T
rs63750959	11921059	4137	MAPT	umls:C0011265	BeFree	Thus, we consider that the Arg5His mutation is an authentic tau gene abnormality responsible for the patient's tau pathology and late-onset dementia.	0.019272373	2002	MAPT	17	45962351	G	A,T
rs63751032	22882713	5663	PSEN1	umls:C0497327	BeFree	We describe here clinical and neuropathological features of a patient with dementia-parkinsonism from a family with a PSEN1 mutation (L420R).	0.046016599	2014	PSEN1	14	73219156	T	G
rs63751032	22882713	5663	PSEN1	umls:C0011265	BeFree	We describe here clinical and neuropathological features of a patient with dementia-parkinsonism from a family with a PSEN1 mutation (L420R).	0.012486326	2014	PSEN1	14	73219156	T	G
rs63751037	9728730	5663	PSEN1	umls:C0497327	BeFree	Herein we report the case of a German EOAD patient with a family history of dementia and a missense mutation at codon 139 (M139V) of the PS-1 gene.	0.046016599	1998	PSEN1	14	73173642	A	G
rs63751037	9728730	5663	PSEN1	umls:C0011265	BeFree	Herein we report the case of a German EOAD patient with a family history of dementia and a missense mutation at codon 139 (M139V) of the PS-1 gene.	0.012486326	1998	PSEN1	14	73173642	A	G
rs63751039	19329229	351	APP	umls:C0497327	BeFree	The Arctic APP mutation (E693G) leads to dementia with clinical features similar to Alzheimer disease (AD), but little is known about the pathogenic mechanism of this mutation.	0.150676439	2011	APP	21	25891855	T	C
rs63751039	19329229	351	APP	umls:C0011265	BeFree	The Arctic APP mutation (E693G) leads to dementia with clinical features similar to Alzheimer disease (AD), but little is known about the pathogenic mechanism of this mutation.	0.007057489	2011	APP	21	25891855	T	C
rs63751273	12876142	4137	MAPT	umls:C0011265	BeFree	Dementia in one or more first-degree family members was found in 43% of patients and mutation analysis of the tau gene showed mutations in 34 patients (19 P301L, five L315R, four G272V, four R406W, one Delta K280 and one S320F), all with a positive family history for dementia (14% of the total population, 32% of patients with a positive family history).	0.019272373	2003	MAPT	17	46010389	C	T
rs63751273	12876142	4137	MAPT	umls:C0497327	BeFree	Dementia in one or more first-degree family members was found in 43% of patients and mutation analysis of the tau gene showed mutations in 34 patients (19 P301L, five L315R, four G272V, four R406W, one Delta K280 and one S320F), all with a positive family history for dementia (14% of the total population, 32% of patients with a positive family history).	0.232545904	2003	MAPT	17	46010389	C	T
rs63751399	11094121	5663	PSEN1	umls:C0497327	BeFree	Dementia with prominent frontotemporal features associated with L113P presenilin 1 mutation.	0.046016599	2000	PSEN1	14	73171047	T	C
rs63751399	11094121	5663	PSEN1	umls:C0011265	BeFree	Dementia with prominent frontotemporal features associated with L113P presenilin 1 mutation.	0.012486326	2000	PSEN1	14	73171047	T	C
rs6489630	23075484	345643	MCIDAS	umls:C0497327	BeFree	Among 215 outpatients with dementia and MCI, 155 with mild AD (n = 108) or A-MCI (n = 47) were recruited and divided into three genotypic groups based on the representative NT-3 functional polymorphisms rs6332 and rs6489630.	0.003528744	2012	NTF3	12	5495458	T	C
rs6489630	23075484	345643	MCIDAS	umls:C0011265	BeFree	Among 215 outpatients with dementia and MCI, 155 with mild AD (n = 108) or A-MCI (n = 47) were recruited and divided into three genotypic groups based on the representative NT-3 functional polymorphisms rs6332 and rs6489630.	0.003528744	2012	NTF3	12	5495458	T	C
rs6557171	23567436	2099	ESR1	umls:C0011265	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.002171535	2012	ESR1	6	151913458	T	C
rs6557171	23567436	1109	AKR1C4	umls:C0497327	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.003257302	2012	ESR1	6	151913458	T	C
rs6557171	23567436	1109	AKR1C4	umls:C0011265	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.003257302	2012	ESR1	6	151913458	T	C
rs6557171	23567436	2099	ESR1	umls:C0497327	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.011639663	2012	ESR1	6	151913458	T	C
rs662	23821382	5444	PON1	umls:C0011265	BeFree	Paraoxonase 1 (PON1) gene-108C>T and p.Q192R polymorphisms and arylesterase activity of the enzyme in patients with dementia.	0.000542884	2014	PON1	7	95308134	T	C
rs662	23821382	5444	PON1	umls:C0497327	BeFree	Paraoxonase 1 (PON1) gene-108C>T and p.Q192R polymorphisms and arylesterase activity of the enzyme in patients with dementia.	0.005905708	2014	PON1	7	95308134	T	C
rs6857	25188341	5819	PVRL2	umls:C0497327	GWASCAT	Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.	0.12	2014	PVRL2	19	44888997	C	T
rs7272891	19468819	5173	PDYN	umls:C0497327	BeFree	Thus, we tested the effect of four SNPs (rs7272891, rs1997794, rs2235751 and rs910080) and the VNTR promoter polymorphism in the prodynorphin gene (PDYN) on episodic memory and verbal fluency in a large (n = 1619) sample of elderly people (mean age: 80 +/- 3.39 years; range 75-90 years) recruited through the German study on ageing, cognition and dementia in primary care patients (AgeCoDe).	0.000271442	2009	PDYN;LOC727993	20	1996172	C	G
rs7272891	19468819	5173	PDYN	umls:C0011265	BeFree	Thus, we tested the effect of four SNPs (rs7272891, rs1997794, rs2235751 and rs910080) and the VNTR promoter polymorphism in the prodynorphin gene (PDYN) on episodic memory and verbal fluency in a large (n = 1619) sample of elderly people (mean age: 80 +/- 3.39 years; range 75-90 years) recruited through the German study on ageing, cognition and dementia in primary care patients (AgeCoDe).	0.000271442	2009	PDYN;LOC727993	20	1996172	C	G
rs74315401	8520719	5621	PRNP	umls:C0011265	BeFree	In contrast, a recent case with proven P102L mutation of the PRNP gene had rapidly developing dementia and severe cortical damage indistinguishable from the clinicopathological phenotype of Creutzfeldt-Jakob disease (CJD).	0.009229024	1995	PRNP	20	4699525	C	T
rs74315401	12200619	5621	PRNP	umls:C0011265	BeFree	Hyperphosphorylated tau deposition parallels prion protein burden in a case of Gerstmann-Sträussler-Scheinker syndrome P102L mutation complicated with dementia.	0.009229024	2002	PRNP	20	4699525	C	T
rs74315401	12200619	5621	PRNP	umls:C0497327	BeFree	Hyperphosphorylated tau deposition parallels prion protein burden in a case of Gerstmann-Sträussler-Scheinker syndrome P102L mutation complicated with dementia.	0.027856281	2002	PRNP	20	4699525	C	T
rs74315401	8520719	5621	PRNP	umls:C0497327	BeFree	In contrast, a recent case with proven P102L mutation of the PRNP gene had rapidly developing dementia and severe cortical damage indistinguishable from the clinicopathological phenotype of Creutzfeldt-Jakob disease (CJD).	0.027856281	1995	PRNP	20	4699525	C	T
rs74315413	15824374	5621	PRNP	umls:C0011265	BeFree	Described is a large family with an autosomal dominant dementia associated with an H187R mutation in the prion protein gene (PRNP).	0.009229024	2005	PRNP	20	4699780	A	G
rs74315413	15824374	5621	PRNP	umls:C0497327	BeFree	Described is a large family with an autosomal dominant dementia associated with an H187R mutation in the prion protein gene (PRNP).	0.027856281	2005	PRNP	20	4699780	A	G
rs80356715	18505686	23435	TARDBP	umls:C0011265	BeFree	Pathogenic TDP-43 gene (TARDBP) mutations have been identified in familial ALS kindreds, and here we report a TARDBP variant (A90V) in a FTLD/ALS patient with a family history of dementia.	0.003528744	2008	TARDBP	1	11016874	C	G,T
rs80356715	18505686	23435	TARDBP	umls:C0497327	BeFree	Pathogenic TDP-43 gene (TARDBP) mutations have been identified in familial ALS kindreds, and here we report a TARDBP variant (A90V) in a FTLD/ALS patient with a family history of dementia.	0.017064619	2008	TARDBP	1	11016874	C	G,T
rs910080	19468819	5173	PDYN	umls:C0497327	BeFree	Thus, we tested the effect of four SNPs (rs7272891, rs1997794, rs2235751 and rs910080) and the VNTR promoter polymorphism in the prodynorphin gene (PDYN) on episodic memory and verbal fluency in a large (n = 1619) sample of elderly people (mean age: 80 +/- 3.39 years; range 75-90 years) recruited through the German study on ageing, cognition and dementia in primary care patients (AgeCoDe).	0.000271442	2009	PDYN;LOC727993	20	1979580	A	G
rs910080	19468819	5173	PDYN	umls:C0011265	BeFree	Thus, we tested the effect of four SNPs (rs7272891, rs1997794, rs2235751 and rs910080) and the VNTR promoter polymorphism in the prodynorphin gene (PDYN) on episodic memory and verbal fluency in a large (n = 1619) sample of elderly people (mean age: 80 +/- 3.39 years; range 75-90 years) recruited through the German study on ageing, cognition and dementia in primary care patients (AgeCoDe).	0.000271442	2009	PDYN;LOC727993	20	1979580	A	G
rs9340799	23567436	1109	AKR1C4	umls:C0011265	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.003257302	2012	ESR1	6	151842246	A	G
rs9340799	23567436	2099	ESR1	umls:C0497327	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.011639663	2012	ESR1	6	151842246	A	G
rs9340799	23567436	1109	AKR1C4	umls:C0497327	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.003257302	2012	ESR1	6	151842246	A	G
rs9340799	23567436	2099	ESR1	umls:C0011265	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.002171535	2012	ESR1	6	151842246	A	G
rs9397456	23567436	1109	AKR1C4	umls:C0497327	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.003257302	2012	ESR1	6	151926017	A	G
rs9397456	23567436	2099	ESR1	umls:C0011265	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.002171535	2012	ESR1	6	151926017	A	G
rs9397456	23567436	1109	AKR1C4	umls:C0011265	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.003257302	2012	ESR1	6	151926017	A	G
rs9397456	23567436	2099	ESR1	umls:C0497327	BeFree	Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5).	0.011639663	2012	ESR1	6	151926017	A	G
rs956572	22198673	596	BCL2	umls:C0497327	BeFree	Effect of Bcl-2 rs956572 SNP on regional gray matter volumes and cognitive function in elderly males without dementia.	0.083267234	2013	BCL2	18	63153338	A	G
rs956572	22198673	596	BCL2	umls:C0011265	BeFree	Effect of Bcl-2 rs956572 SNP on regional gray matter volumes and cognitive function in elderly males without dementia.	0.000542884	2013	BCL2	18	63153338	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:211)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	72461382	rs12139692	C	T	rs12139692	22116812	3.46E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NEGR1
1	100592653	rs663519	A	G	rs663519	22116812	5.59E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	SASS6
1	205045087	rs1572993	G	A	rs1572993	20154673	6.63E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
1	205070573	rs11240358	G	A	rs11240358	20154673	4.12E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
1	205110929	rs11240368	T	C	rs11240368	20154673	9.01E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
1	205236233	rs4951182	A	C	rs4951182	20154673	3.03E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
1	205261174	rs1172122	T	C	rs1172122	20154673	5.65E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
1	205261963	rs10157145	T	C	rs10157145	20154673	4.12E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
2	60336589	rs17039713	G	T	rs17039713	22116812	4.29E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	NA
2	123826562	rs299541	G	A	rs299541	22116812	3.02E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	NA
2	123857742	rs10183651	C	T	rs10183651	22116812	8.33E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
2	157529654	rs7602743	G	A	rs7602743	22116812	9.86E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
2	235284355	rs7572928	C	T	rs7572928	22116812	8.19E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
3	134830532	rs10935154	T	C	rs10935154	22116812	5.83E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	EPHB1
3	134841452	rs11706256	C	T	rs11706256	22116812	7.28E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	EPHB1
3	179455796	rs17195948	G	A	rs17195948	22116812	1.02E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	USP13
3	179482482	rs1024852	T	C	rs1024852	22116812	6.91E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	USP13
4	5405805	rs10010358	C	A	rs10010358	22116812	1.08E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	STK32B
4	5413525	rs195113	C	T	rs195113	22116812	6.97E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	STK32B
4	24286919	rs1510787	A	G	rs1510787	22116812	3.36E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	NA
4	140631137	rs17050873	C	T	rs17050873	22116812	6.21E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	MGST2
5	80278998	rs7717830	G	T	rs7717830	22116812	2.87E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	RASGRF2
5	80323368	rs10491487	T	G	rs10491487	22116812	3.65E-08	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	RASGRF2
5	80364887	rs26906	T	C	rs26906	22116812	4.01E-07	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	RASGRF2
5	81220187	rs687543	C	T	rs687543	22116812	4.63E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
5	81226548	rs589080	A	C	rs589080	22116812	3.37E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	NA
5	134405161	rs13436118	G	A	rs13436118	22116812	5.08E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
5	158137439	rs17056109	C	T	rs17056109	22116812	9.99E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	EBF1
6	8171106	rs6930720	C	T	rs6930720	22116812	1.12E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
6	32321554	rs2395148	G	T	rs2395148	22116812	2.39E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	C6orf10
6	32363215	rs1980493	T	C	rs1980493	24943344	1.57E-08	(All Frontotemporal dementia)	1.29	[1.16-1.45]	1,377 European ancestry behavioural variant cases; 308 European ancestry Semantic dementia cases; 269 European ancestry Progressive nonfluent aphasia cases; 200 European ancestry Frontotremporal dementia with motor neuron disease cases; up to 4,308 European ancestry controls	European(6462)	ALL(6462)	EUR(6462)	ALL(6462)	Frontotemporal dementia	HPOID:0000726	Dementia	DOID:9255	frontotemporal dementia	NA	NA	NA	NA	Brain disease	Alzheimer's disease	rs1980493-T	Multicenter Study	Research Support, N.I.H., Extramural
6	32429719	rs9268856	C	A	rs9268856	24943344	5.51E-09	(All Frontotemporal dementia)	1.24	[1.16-1.32]	1,377 European ancestry behavioural variant cases; 308 European ancestry Semantic dementia cases; 269 European ancestry Progressive nonfluent aphasia cases; 200 European ancestry Frontotremporal dementia with motor neuron disease cases; up to 4,308 European ancestry controls	European(6462)	ALL(6462)	EUR(6462)	ALL(6462)	Frontotemporal dementia	HPOID:0000726	Dementia	DOID:9255	frontotemporal dementia	NA	NA	NA	NA	Brain disease	Alzheimer's disease	rs9268856-C	Multicenter Study	Research Support, N.I.H., Extramural
6	32429719	rs9268856	C	A	rs9268856	24943344	6.00E-09	(All Frontotemporal dementia)	1.24	[1.16-1.32]	1,377 European ancestry behavioural variant cases; 308 European ancestry Semantic dementia cases; 269 European ancestry Progressive nonfluent aphasia cases; 200 European ancestry Frontotremporal dementia with motor neuron disease cases; up to 4,308 European ancestry controls	European(6462)	ALL(6462)	EUR(6462)	ALL(6462)	Frontotemporal dementia	HPOID:0000726	Dementia	DOID:9255	frontotemporal dementia	NA	NA	NA	NA	Brain disease	Alzheimer's disease	rs9268856-C	Multicenter Study	Research Support, N.I.H., Extramural
6	32431147	rs9268877	A	G	rs9268877	24943344	1.05E-08	(All Frontotemporal dementia)	1.2	[1.11-1.30]	1,377 European ancestry behavioural variant cases; 308 European ancestry Semantic dementia cases; 269 European ancestry Progressive nonfluent aphasia cases; 200 European ancestry Frontotremporal dementia with motor neuron disease cases; up to 4,308 European ancestry controls	European(6462)	ALL(6462)	EUR(6462)	ALL(6462)	Frontotemporal dementia	HPOID:0000726	Dementia	DOID:9255	frontotemporal dementia	NA	NA	NA	NA	Brain disease	Alzheimer's disease	rs9268877-A	Multicenter Study	Research Support, N.I.H., Extramural
6	85489234	rs141127	C	T	rs141127	22116812	9.13E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	NA
6	164106739	rs9365597	G	A	rs9365597	22116812	1.85E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	NA
7	12164100	rs1003433	G	T	rs1003433	20154673	5.28E-05	Frontotemporal lobar degeneration with TDP-43 inclusions	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12164100	rs1003433	G	T	rs1003433	20154673	5.51E-04	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12200060	rs6952272	C	T	rs6952272	20154673	2.62E-04	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12200060	rs6952272	C	T	rs6952272	20154673	4.75E-05	Frontotemporal lobar degeneration with TDP-43 inclusions	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12215562	rs12671332	T	C	rs12671332	20154673	1.32E-04	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12215562	rs12671332	T	C	rs12671332	20154673	3.03E-07	Frontotemporal lobar degeneration with TDP-43 inclusions	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12215562	rs12671332	T	C	rs12671332	20154673	9.79E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12227892	rs1468915	A	G	rs1468915	20154673	1.42E-04	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12227892	rs1468915	A	G	rs1468915	20154673	1.45E-04	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12227892	rs1468915	A	G	rs1468915	20154673	4.68E-07	Frontotemporal lobar degeneration with TDP-43 inclusions	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12255778	rs1020004	T	C	rs1020004	20154673	1.10E-06	TMEM106B gene expression	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12255778	rs1020004	T	C	rs1020004	20154673	1.93E-07	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12255778	rs1020004	T	C	rs1020004	20154673	2.90E-11	Frontotemporal lobar degeneration with TDP-43 inclusions	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12255778	rs1020004	T	C	rs1020004	20154673	4.15E-07	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12265988	rs6966915	C	T	rs6966915	20154673	3.92E-09	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12265988	rs6966915	C	T	rs6966915	20154673	6.49E-07	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12265988	rs6966915	C	T	rs6966915	20154673	6.87E-12	Frontotemporal lobar degeneration with TDP-43 inclusions	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12277081	rs10488192	G	A	rs10488192	20154673	1.46E-06	Frontotemporal lobar degeneration with TDP-43 inclusions	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12283787	rs1990622	A	G	rs1990622	20154673	1.34E-09	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12283787	rs1990622	A	G	rs1990622	20154673	4.31E-12	Frontotemporal lobar degeneration with TDP-43 inclusions	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12283787	rs1990622	A	G	rs1990622	20154673	6.90E-07	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12283787	rs1990622	A	G	rs1990622	20154673	6.90E-08	TMEM106B gene expression	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	12286409	rs6945902	C	A	rs6945902	20154673	7.17E-04	Frontotemporal lobar degeneration with TDP-43 inclusions	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
7	80947517	rs10486820	A	G	rs10486820	22116812	7.70E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G,A	NA
8	5443069	rs11776337	G	A	rs11776337	22116812	5.21E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
8	137772759	rs2610084	T	C	rs2610084	20154673	3.38E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137776731	rs2582478	A	G	rs2582478	20154673	3.38E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137779259	rs2610088	T	C	rs2610088	20154673	3.19E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137787569	rs2610093	A	G	rs2610093	20154673	3.19E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137812540	rs2610114	T	C	rs2610114	20154673	3.94E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137814067	rs2610116	A	G	rs2610116	20154673	2.60E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137814585	rs2649130	G	A	rs2649130	20154673	2.60E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137814742	rs2649129	G	A	rs2649129	20154673	1.00E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137815685	rs2649127	T	C	rs2649127	20154673	1.76E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137815729	rs2649126	G	A	rs2649126	20154673	2.72E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137817574	rs2582454	C	T	rs2582454	20154673	2.81E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137818388	rs2649123	T	G	rs2649123	20154673	2.81E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137822965	rs10505665	G	A	rs10505665	20154673	3.24E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137825180	rs2613815	G	A	rs2613815	20154673	2.18E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137826173	rs2610127	C	T	rs2610127	20154673	2.44E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137826900	rs2613817	G	T	rs2613817	20154673	2.51E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137827853	rs2610128	C	T	rs2610128	20154673	2.66E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137828862	rs2582447	A	G	rs2582447	20154673	2.51E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137829950	rs1979813	G	T	rs1979813	20154673	2.72E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137830784	rs2582444	C	T	rs2582444	20154673	3.08E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137833740	rs2582435	A	G	rs2582435	20154673	4.26E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137835656	rs2610067	T	C	rs2610067	20154673	4.26E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
8	137836277	rs2582431	C	T	rs2582431	20154673	3.11E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
9	27516590	rs774352	T	C	rs774352	20154673	2.75E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
9	27516640	rs774351	A	C	rs774351	20154673	2.89E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
9	27536397	rs2814707	C	T	rs2814707	20154673	5.72E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
9	27543281	rs3849942	T	C	rs3849942	20154673	1.38E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
9	27561049	rs774359	T	C	rs774359	20154673	7.66E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
9	87734520	rs1931109	T	G	rs1931109	22116812	7.84E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	NA
9	87739737	rs12348840	C	T	rs12348840	22116812	9.72E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
9	87759493	rs17088268	G	A,C,T	rs17088268	22116812	9.04E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
9	93636664	rs290227	G	A	rs290227	23480133	7.00E-11	NA	2.2	[1.73-2.78]	84 Korean ancestry cases; 200 Korean ancestry controls	Korean(284)	ALL(284)	ASN(284)	ALL(284)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	rs290227-G	Research Support, Non-U.S. Gov't	C	SYK
9	101281175	rs16916777	G	A	rs16916777	22116812	1.09E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	GABBR2
9	133003943	rs7868152	G	A	rs7868152	22116812	9.52E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
10	813426	rs11253424	C	T	rs11253424	22116812	3.23E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
10	16068563	rs10904665	G	A	rs10904665	20154673	8.83E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
10	16070792	rs947335	T	C	rs947335	20154673	6.72E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
10	16070912	rs2015326	T	G	rs2015326	20154673	7.41E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
10	16112933	rs11253762	T	C	rs11253762	20154673	3.51E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
10	16131289	rs11253773	T	C	rs11253773	20154673	6.85E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
10	16138489	rs11253779	C	T	rs11253779	20154673	2.01E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
10	16145787	rs7098374	T	C	rs7098374	20154673	8.62E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
10	16147479	rs1417096	A	G	rs1417096	20154673	3.11E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
10	16148908	rs1340151	G	A	rs1340151	20154673	7.93E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
10	16151893	rs6602078	C	A	rs6602078	20154673	2.87E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
10	16156836	rs1340145	G	A	rs1340145	20154673	7.52E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
10	16158880	rs10795348	C	T	rs10795348	20154673	3.40E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
10	44406205	rs10899949	A	G	rs10899949	22116812	2.25E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	LOC283033
10	44427021	rs10899952	G	T	rs10899952	22116812	4.75E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	LOC283033
10	44428985	rs11238781	A	G	rs11238781	22116812	4.24E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	LOC283033
10	90498121	rs12357879	G	A	rs12357879	22116812	9.10E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	LIPK
10	105356031	rs17738042	G	A	rs17738042	22116812	1.31E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	SH3PXD2A
11	6322284	rs10839548	A	C	rs10839548	22116812	2.48E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	NA
11	76236220	rs1939469	A	G	rs1939469	22116812	9.49E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	C11orf30
11	77068770	rs1453342	C	A	rs1453342	22116812	2.85E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	PAK1
11	86492840	rs744293	G	A	rs744293	20154673	2.74E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
11	86503137	rs2015747	C	A	rs2015747	20154673	1.32E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
11	86504356	rs12799567	A	G	rs12799567	20154673	9.40E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation negative)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
11	87876911	rs302668	T	C	rs302668	24943344	2.00E-07	(Behavioural variant FTD)	1.23	[1.09-1.41]	1,377 European ancestry behavioural variant cases; 308 European ancestry Semantic dementia cases; 269 European ancestry Progressive nonfluent aphasia cases; 200 European ancestry Frontotremporal dementia with motor neuron disease cases; up to 4,308 European ancestry controls	European(6462)	ALL(6462)	EUR(6462)	ALL(6462)	Frontotemporal dementia	HPOID:0000726	Dementia	DOID:9255	frontotemporal dementia	NA	NA	NA	NA	Brain disease	Alzheimer's disease	rs302668-T	Multicenter Study	Research Support, N.I.H., Extramural
11	87934068	rs16913634	G	A	rs16913634	24943344	8.15E-04	(Behavioural variant FTD)	1.25	[1.14-1.37]	1,377 European ancestry behavioural variant cases; 308 European ancestry Semantic dementia cases; 269 European ancestry Progressive nonfluent aphasia cases; 200 European ancestry Frontotremporal dementia with motor neuron disease cases; up to 4,308 European ancestry controls	European(6462)	ALL(6462)	EUR(6462)	ALL(6462)	Frontotemporal dementia	HPOID:0000726	Dementia	DOID:9255	frontotemporal dementia	NA	NA	NA	NA	Brain disease	Alzheimer's disease	rs16913634-A	Multicenter Study	Research Support, N.I.H., Extramural
12	2333652	rs11062164	C	A	rs11062164	22116812	5.61E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	CACNA1C
12	72602045	rs17110927	T	C	rs17110927	22116812	1.74E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
12	129581856	rs11060130	T	G	rs11060130	22116812	9.96E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	TMEM132D
12	131330173	rs4420312	T	C	rs4420312	22116812	5.57E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	NA
13	51178370	rs484304	C	T	rs484304	22116812	2.40E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
13	51226954	rs797512	T	C	rs797512	22116812	4.52E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
13	51227415	rs797515	G	A	rs797515	22116812	5.93E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	NA
13	51230621	rs797516	A	G	rs797516	22116812	4.00E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
13	51254712	rs2540525	C	T	rs2540525	22116812	9.55E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
13	105901503	rs3015361	C	A	rs3015361	22116812	1.30E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	NA
13	105908875	rs4485213	C	T	rs4485213	22116812	2.57E-07	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
13	105929262	rs7989487	C	T	rs7989487	22116812	2.78E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
14	97508288	rs1950268	T	C	rs1950268	22116812	1.83E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	NA
15	58532507	rs11632498	T	C	rs11632498	22116812	1.48E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
15	82454283	rs9972386	A	G	rs9972386	22116812	5.77E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	EFTUD1
15	97940810	rs4076597	T	C	rs4076597	22116812	4.11E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	NA
16	25329195	rs7191284	T	G	rs7191284	22116812	1.93E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	NA
17	19809749	rs203467	C	T	rs203467	22116812	4.86E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	AKAP10
17	42679220	rs11655190	G	A	rs11655190	20154673	3.49E-10	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
17	42746144	rs8079488	C	T	rs8079488	20154673	6.30E-11	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
17	42753873	rs3897489	A	G	rs3897489	20154673	7.00E-11	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
17	42827673	rs3744477	G	A	rs3744477	20154673	3.78E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
17	42835495	rs4426386	A	G	rs4426386	20154673	2.16E-09	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
17	42860326	rs4043263	G	A	rs4043263	20154673	2.69E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
17	42867443	rs8064954	A	C	rs8064954	20154673	4.79E-09	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
17	42874870	rs8064669	C	T	rs8064669	20154673	3.04E-07	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
17	42935059	rs8069296	T	C	rs8069296	20154673	4.60E-05	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
17	42939170	rs9910260	G	A	rs9910260	20154673	8.44E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
17	42955589	rs9914884	T	C	rs9914884	20154673	6.99E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
17	42973313	rs9908594	G	A	rs9908594	20154673	7.92E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
17	42981499	rs12937256	C	T	rs12937256	20154673	6.03E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
17	42981654	rs3826425	A	G	rs3826425	20154673	5.13E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
17	42982288	rs3744473	A	G	rs3744473	20154673	7.33E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
17	43030679	rs12941574	T	C	rs12941574	20154673	1.20E-06	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
17	43035377	rs4793166	G	A	rs4793166	20154673	1.82E-04	Frontotemporal lobar degeneration with TDP-43 inclusions (GRN mutation carriers)	NA	NA	515 European ancestry cases; 2509 European ancestry controls	European(3024)	ALL(3024)	EUR(3024)	ALL(3024)	Frontotemporal lobar degeneration with TDP-43 inclusions, in brain	HPOID:0000707	Abnormality of the nervous system	DOID:1307	dementia	NA	NA	NA	NA	Mental retardation	Alzheimer's disease	NA	Multicenter Study	Research Support, N.I.H., Extramural
18	5396976	rs11661371	C	T	rs11661371	22116812	2.21E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	EPB41L3
18	52809403	rs4800982	G	A	rs4800982	22116812	1.17E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A,G	NA
18	65043085	rs2045262	T	C	rs2045262	22116812	2.12E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	NA
18	65223793	rs3886594	G	A	rs3886594	22116812	6.42E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	LOC643542
19	43815568	rs8113515	C	A	rs8113515	22116812	6.81E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	NA
20	22576515	rs1203917	T	C	rs1203917	22116812	4.00E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
20	22581060	rs6036158	T	C	rs6036158	22116812	3.15E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
20	59640730	rs13040003	C	A	rs13040003	22116812	3.33E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
21	28132381	rs9636785	T	C	rs9636785	22116812	1.02E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	NA
22	24257779	rs9608216	C	T	rs9608216	22116812	5.62E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
X	65392636	rs7054364	C	A	rs7054364	22116812	4.90E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	HEPH
X	65416087	rs1011526	G	A	rs1011526	22116812	4.70E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	HEPH
X	66267248	rs532649	A	G	rs532649	22116812	7.38E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66268202	rs485454	A	G	rs485454	22116812	8.01E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66301034	rs989345	G	A	rs989345	22116812	6.95E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66316431	rs1511060	C	T	rs1511060	22116812	9.60E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66318768	rs5918694	T	C	rs5918694	22116812	9.38E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	NA
X	66321962	rs4827392	C	A	rs4827392	22116812	9.92E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
X	66336727	rs938059	C	A	rs938059	22116812	8.87E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66347684	rs1988995	T	C	rs1988995	22116812	9.83E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	NA
X	66507096	rs4827539	C	T	rs4827539	22116812	5.40E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
X	66508679	rs5919362	T	G	rs5919362	22116812	5.31E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66510458	rs4601479	G	A	rs4601479	22116812	5.46E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	NA
X	66510984	rs6625163	G	A	rs6625163	22116812	5.41E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66512103	rs5919363	G	A	rs5919363	22116812	4.20E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66519508	rs5965383	G	T	rs5965383	22116812	3.05E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66519714	rs2335506	G	A	rs2335506	22116812	3.98E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66520650	rs2335508	A	G	rs2335508	22116812	3.74E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	NA
X	66530532	rs6625174	G	A	rs6625174	22116812	4.29E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66538729	rs2878642	A	G	rs2878642	22116812	4.98E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66540111	rs2336175	A	G	rs2336175	22116812	3.94E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66563018	rs2497938	T	C	rs2497938	22116812	3.69E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
X	66564014	rs2497939	A	C	rs2497939	22116812	3.96E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	NA
X	66564352	rs2223842	A	C	rs2223842	22116812	3.81E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G,T	NA
X	66566096	rs2497943	T	G	rs2497943	22116812	4.10E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66566450	rs2473897	T	C	rs2473897	22116812	4.06E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66567742	rs2497944	G	A	rs2497944	22116812	3.02E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66570171	rs2223841	T	C	rs2223841	22116812	3.96E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66570727	rs2473896	T	C	rs2473896	22116812	3.96E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66571037	rs2473895	C	T	rs2473895	22116812	3.91E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66573743	rs2207080	A	G	rs2207080	22116812	3.69E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
X	66576324	rs721451	A	G	rs721451	22116812	3.06E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
X	66576473	rs2473891	C	T	rs2473891	22116812	4.20E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	NA
X	66627440	rs2497911	C	A	rs2497911	22116812	5.58E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	NA
X	66648216	rs2497928	A	C	rs2497928	22116812	3.93E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
X	66656276	rs2497931	A	C	rs2497931	22116812	1.53E-07	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	A	NA
X	66664083	rs2473849	C	A	rs2473849	22116812	5.25E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	NA
X	66748355	rs12007229	C	A	rs12007229	22116812	1.33E-08	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
X	66777066	rs12396249	G	A	rs12396249	22116812	3.30E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	G	AR
X	66825357	rs5919393	C	T	rs5919393	22116812	5.37E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	AR
X	66875756	rs6624304	T	C	rs6624304	22116812	3.08E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	AR
X	66938466	rs12014709	T	G	rs12014709	22116812	9.32E-06	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	AR
X	67021550	rs5919432	C	T	rs5919432	22116812	4.71E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	T	NA
X	67028222	rs4456006	C	A	rs4456006	22116812	4.87E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA
X	67062490	rs4827556	C	T	rs4827556	22116812	4.63E-05	NA	NA	NA	67 European ancestry cases; 5,633 European ancestry controls	European(5700)	ALL(5700)	EUR(5700)	ALL(5700)	Vascular dementia	HPOID:0000726	Dementia	DOID:8725	vascular dementia	D015140	Dementia, Vascular	EFOID:0004718	vasuclar dementia	Vascular dementia	NA	Research Support, Non-U.S. Gov't	C	NA

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:22)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0011265	s-adenosylmethionine	D012436	29908-03-0	dementia	MESH:D003704	therapeutic	7527320
C0011265	ceftazidime	D002442	78439-06-2	dementia	MESH:D003704	marker/mechanism	14671069
C0011265	cimetidine	D002927	51481-61-9	dementia	MESH:D003704	marker/mechanism	4031401
C0011265	clonidine	D003000	4205-90-7	dementia	MESH:D003704	marker/mechanism	1125640
C0011265	clozapine	D003024	5786-21-0	dementia	MESH:D003704	therapeutic	18759705
C0011265	digoxin	D004077	20830-75-5	dementia	MESH:D003704	marker/mechanism	17326274
C0011265	fluorouracil	D005472	51-21-8	dementia	MESH:D003704	marker/mechanism	7583711
C0011265	folic acid	D005492	59-30-3	dementia	MESH:D003704	marker/mechanism	7527320
C0011265	haloperidol	D006220	52-86-8	dementia	MESH:D003704	marker/mechanism	1264138
C0011265	haloperidol	D006220	52-86-8	dementia	MESH:D003704	therapeutic	11575062
C0011265	loxapine	D008152	1977/10/2	dementia	MESH:D003704	therapeutic	7114310
C0011265	medroxyprogesterone acetate	D017258	71-58-9	dementia	MESH:D003704	marker/mechanism	12771112
C0011265	methotrexate	D008727	1959/5/2	dementia	MESH:D003704	marker/mechanism	15003295
C0011265	moxifloxacin	C104727	-	dementia	MESH:D003704	marker/mechanism	19097002
C0011265	nimodipine	D009553	66085-59-4	dementia	MESH:D003704	therapeutic	3323259
C0011265	nortriptyline	D009661	72-69-5	dementia	MESH:D003704	marker/mechanism	1390620
C0011265	olanzapine	C076029	132539-06-1	dementia	MESH:D003704	therapeutic	16368923
C0011265	phenytoin	D010672	57-41-0	dementia	MESH:D003704	marker/mechanism	9469697
C0011265	pilocarpine	D010862	92-13-7	dementia	MESH:D003704	marker/mechanism	8196113
C0011265	progesterone	D011374	57-83-0	dementia	MESH:D003704	marker/mechanism	14558187
C0011265	streptozocin	D013311	18883-66-4	dementia	MESH:D003704	marker/mechanism	19494442
C0011265	valproic acid	D014635	99-66-1	dementia	MESH:D003704	marker/mechanism	11201978

FDA approved drug and dosage information(Total Drugs:4)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D003704	zyprexa	olanzapine	2.5MG	TABLET;ORAL	Prescription	AB	Yes	No
MESH:D003704	zyprexa	olanzapine	10MG/VIAL	INJECTABLE;INTRAMUSCULAR	Prescription	AP	Yes	Yes
MESH:D003704	zyprexa	olanzapine	2.5MG	TABLET;ORAL	Prescription	AB	Yes	No
MESH:D003704	zyprexa	olanzapine	10MG/VIAL	INJECTABLE;INTRAMUSCULAR	Prescription	AP	Yes	Yes

FDA labeling changes(Total Drugs:4)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D003704	08/14/2008	zyprexa	olanzapine	schizophrenia; bipolar disorder	Safety and effectiveness have not been established for patients less than 18 years of age In an analysis of placebo-controlled olanzapine monotherapy studies of adolescent patients, including those with schizophrenia or bipolar disorder, olanzapine was associated with: oHyperglycemia - a statistically significantly greater mean change in fasting glucose levels compared to placebo oHyperlipidemia statistically significant increases compared to placebo in fasting triglycerides, fasting total cholesterol and fasting LDL cholesterol oWeight gain olanzapine treated patients gained an average of 4.6 kg, compared to an average of 0.3 kg in placebo-treated patients with a median exposure of 3 weeks; Average weight gain during long-term therapy was 7.4 kg	-	B	-	-	-	Lilly	10/1/2007	FALSE'
MESH:D003704	08/14/2008	zyprexa	olanzapine	schizophrenia; bipolar disorder	Safety and effectiveness have not been established for patients less than 18 years of age In an analysis of placebo-controlled olanzapine monotherapy studies of adolescent patients, including those with schizophrenia or bipolar disorder, olanzapine was associated with: oHyperglycemia - a statistically significantly greater mean change in fasting glucose levels compared to placebo oHyperlipidemia statistically significant increases compared to placebo in fasting triglycerides, fasting total cholesterol and fasting LDL cholesterol oWeight gain olanzapine treated patients gained an average of 4.6 kg, compared to an average of 0.3 kg in placebo-treated patients with a median exposure of 3 weeks; Average weight gain during long-term therapy was 7.4 kg	-	B	-	-	-	Lilly	10/1/2007	FALSE'
MESH:D003704	4/12/2009	zyprexa	olanzapine	Treatment of manic or mixed episodes of bipolar I disorder and schizophrenia in adolescents ages 13-17	Extended schizophrenia and manic or mixed episodes of bipolar I disorder indications from adults to adolescents 1317 years of age Safety and effectiveness in children < 13 years of age have not been established Recommended starting dose for adolescents is lower than that for adults Compared to patients from adult clinical trials, adolescents were likely to gain more weight, experience increased sedation, and have greater increases in total cholesterol, triglycerides, LDL cholesterol, prolactin and hepatic transaminase levels Information on dosing, adverse reactions, pharmacokinetics, clinical studies	Labeling	B	-	-	-	Lilly	10/1/2007	TRUE'
MESH:D003704	4/12/2009	zyprexa	olanzapine	Treatment of manic or mixed episodes of bipolar I disorder and schizophrenia in adolescents ages 13-17	Extended schizophrenia and manic or mixed episodes of bipolar I disorder indications from adults to adolescents 1317 years of age Safety and effectiveness in children < 13 years of age have not been established Recommended starting dose for adolescents is lower than that for adults Compared to patients from adult clinical trials, adolescents were likely to gain more weight, experience increased sedation, and have greater increases in total cholesterol, triglycerides, LDL cholesterol, prolactin and hepatic transaminase levels Information on dosing, adverse reactions, pharmacokinetics, clinical studies	Labeling	B	-	-	-	Lilly	10/1/2007	TRUE'