PedAM

Pediatric Disease Annotations & Medicines


	degenerative disc disease

Disease ID	673
Disease	degenerative disc disease
Definition	Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.
Synonym	degeneration disc degeneration disc intervertebral degeneration of intervertebral disc degeneration of intervertebral disc (disorder) degeneration of intervertebral disc, nos degeneration of intervertebral disc, site unspecified degeneration of intervertebral disks degeneration, disc degeneration, disk degeneration, intervertebral disc degeneration, intervertebral disk degenerations, disc degenerations, disk degenerations, intervertebral disc degenerations, intervertebral disk degenerative disc disease nos degenerative disc disease nos (disorder) degenerative disc disease, nos degenerative disc diseases degenerative intervertebral disk degradation, disc degradation, disk degradations, disc degradations, disk disc degeneration disc degeneration nos disc degeneration, intervertebral disc degenerations disc degenerations, intervertebral disc degenerative disease disc degradation disc degradations disc disease degenerative disk degeneration disk degeneration, intervertebral disk degenerations disk degenerations, intervertebral disk degradation disk degradations intervertebral disc degeneration intervertebral disc degeneration [disease/finding] intervertebral disc degenerations intervertebral disc degenerative disease intervertebral disc degenerative disorder intervertebral disk degeneration intervertebral disk degenerations vertebral disc degenerative disease vertebral disc degenerative disorder
DOID	DOID:90
UMLS	C0158266
MeSH	D055959
SNOMED-CT	SNOMEDCT_US_2016_09_01:77547008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:7) C0700594 \| radiculopathy \| 7 C0037928 \| myelopathy \| 3 C0037944 \| spinal stenosis \| 2 C0029408 \| osteoarthritis \| 1 C0158266 \| disc degeneration \| 1 C0038016 \| spondylolisthesis \| 1 C0022821 \| kyphosis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) TGFB1 \| 7040 \| CTD_human PARK2 \| 5071 \| GWASCAT CSMD1 \| 64478 \| GWASCAT SPARC \| 6678 \| CTD_human GPC6 \| 10082 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:10) 1302 \| COL11A2 \| infer 1280 \| COL2A1 \| infer 1298 \| COL9A2 \| infer 1299 \| COL9A3 \| infer 3553 \| IL1B \| infer 3552 \| IL1A \| infer 3569 \| IL6 \| infer 4314 \| MMP3 \| infer 7421 \| VDR \| infer 176 \| ACAN \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:197) 103611090 \| CDR1-AS \| DISEASES 972 \| CD74 \| DISEASES 2067 \| ERCC1 \| DISEASES 1634 \| DCN \| DISEASES 771 \| CA12 \| DISEASES 23411 \| SIRT1 \| DISEASES 6300 \| MAPK12 \| DISEASES 7076 \| TIMP1 \| DISEASES 4313 \| MMP2 \| DISEASES 7040 \| TGFB1 \| DISEASES 657 \| BMPR1A \| DISEASES 10951 \| CBX1 \| DISEASES 40 \| ASIC2 \| DISEASES 1277 \| COL1A1 \| DISEASES 9450 \| LY86 \| DISEASES 8809 \| IL18R1 \| DISEASES 9519 \| TBPL1 \| DISEASES 7043 \| TGFB3 \| DISEASES 6662 \| SOX9 \| DISEASES 3236 \| HOXD10 \| DISEASES 79148 \| MMP28 \| DISEASES 6320 \| CLEC11A \| DISEASES 112399 \| EGLN3 \| DISEASES 25873 \| RPL36 \| DISEASES 22856 \| CHSY1 \| DISEASES 2012 \| EMP1 \| DISEASES 11095 \| ADAMTS8 \| DISEASES 4907 \| NT5E \| DISEASES 3569 \| IL6 \| DISEASES 3364 \| HUS1 \| DISEASES 1101 \| CHAD \| DISEASES 3557 \| IL1RN \| DISEASES 7097 \| TLR2 \| DISEASES 4322 \| MMP13 \| DISEASES 8483 \| CILP \| DISEASES 2294 \| FOXF1 \| DISEASES 64750 \| SMURF2 \| DISEASES 9368 \| SLC9A3R1 \| DISEASES 7077 \| TIMP2 \| DISEASES 5595 \| MAPK3 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 2247 \| FGF2 \| DISEASES 658 \| BMPR1B \| DISEASES 1462 \| VCAN \| DISEASES 10512 \| SEMA3C \| DISEASES 10371 \| SEMA3A \| DISEASES 127 \| ADH4 \| DISEASES 25996 \| REXO2 \| DISEASES 7078 \| TIMP3 \| DISEASES 4060 \| LUM \| DISEASES 11081 \| KERA \| DISEASES 50511 \| SYCP3 \| DISEASES 3480 \| IGF1R \| DISEASES 7157 \| TP53 \| DISEASES 396 \| ARHGDIA \| DISEASES 207 \| AKT1 \| DISEASES 4209 \| MEF2D \| DISEASES 2495 \| FTH1 \| DISEASES 1404 \| HAPLN1 \| DISEASES 8817 \| FGF18 \| DISEASES 4851 \| NOTCH1 \| DISEASES 60496 \| AASDHPPT \| DISEASES 55079 \| FEZF2 \| DISEASES 64422 \| ATG3 \| DISEASES 223117 \| SEMA3D \| DISEASES 7070 \| THY1 \| DISEASES 56172 \| ANKH \| DISEASES 9510 \| ADAMTS1 \| DISEASES 11096 \| ADAMTS5 \| DISEASES 4325 \| MMP16 \| DISEASES 392255 \| GDF6 \| DISEASES 9941 \| EXOG \| DISEASES 148113 \| CILP2 \| DISEASES 8566 \| PDXK \| DISEASES 9794 \| MAML1 \| DISEASES 3856 \| KRT8 \| DISEASES 11167 \| FSTL1 \| DISEASES 308 \| ANXA5 \| DISEASES 9311 \| ASIC3 \| DISEASES 84889 \| SLC7A3 \| DISEASES 1073 \| CFL2 \| DISEASES 2619 \| GAS1 \| DISEASES 4314 \| MMP3 \| DISEASES 8772 \| FADD \| DISEASES 79058 \| ASPSCR1 \| DISEASES 3479 \| IGF1 \| DISEASES 3688 \| ITGB1 \| DISEASES 214 \| ALCAM \| DISEASES 125 \| ADH1B \| DISEASES 200558 \| APLF \| DISEASES 4323 \| MMP14 \| DISEASES 6670 \| SP3 \| DISEASES 55790 \| CSGALNACT1 \| DISEASES 836 \| CASP3 \| DISEASES 5883 \| RAD9A \| DISEASES 8560 \| DEGS1 \| DISEASES 6936 \| GCFC2 \| DISEASES 6863 \| TAC1 \| DISEASES 6569 \| SLC34A1 \| DISEASES 4312 \| MMP1 \| DISEASES 55553 \| SOX6 \| DISEASES 7481 \| WNT11 \| DISEASES 51330 \| TNFRSF12A \| DISEASES 633 \| BGN \| DISEASES 3714 \| JAG2 \| DISEASES 842 \| CASP9 \| DISEASES 5580 \| PRKCD \| DISEASES 3418 \| IDH2 \| DISEASES 9543 \| IGDCC3 \| DISEASES 5600 \| MAPK11 \| DISEASES 51548 \| SIRT6 \| DISEASES 3091 \| HIF1A \| DISEASES 554 \| AVPR2 \| DISEASES 857 \| CAV1 \| DISEASES 1299 \| COL9A3 \| DISEASES 545 \| ATR \| DISEASES 3605 \| IL17A \| DISEASES 8045 \| RASSF7 \| DISEASES 1499 \| CTNNB1 \| DISEASES 6218 \| RPS17 \| DISEASES 2331 \| FMOD \| DISEASES 9260 \| PDLIM7 \| DISEASES 23154 \| NCDN \| DISEASES 84870 \| RSPO3 \| DISEASES 64116 \| SLC39A8 \| DISEASES 6421 \| SFPQ \| DISEASES 1297 \| COL9A1 \| DISEASES 841 \| CASP8 \| DISEASES 405 \| ARNT \| DISEASES 799 \| CALCR \| DISEASES 5599 \| MAPK8 \| DISEASES 1312 \| COMT \| DISEASES 3880 \| KRT19 \| DISEASES 8678 \| BECN1 \| DISEASES 54583 \| EGLN1 \| DISEASES 7058 \| THBS2 \| DISEASES 5743 \| PTGS2 \| DISEASES 356 \| FASLG \| DISEASES 1490 \| CTGF \| DISEASES 9507 \| ADAMTS4 \| DISEASES 5654 \| HTRA1 \| DISEASES 4803 \| NGF \| DISEASES 3654 \| IRAK1 \| DISEASES 1301 \| COL11A1 \| DISEASES 164045 \| HFM1 \| DISEASES 60495 \| HPSE2 \| DISEASES 2258 \| FGF13 \| DISEASES 1791 \| DNTT \| DISEASES 860 \| RUNX2 \| DISEASES 11124 \| FAF1 \| DISEASES 11093 \| ADAMTS13 \| DISEASES 4318 \| MMP9 \| DISEASES 6385 \| SDC4 \| DISEASES 1298 \| COL9A2 \| DISEASES 9469 \| CHST3 \| DISEASES 2022 \| ENG \| DISEASES 26190 \| FBXW2 \| DISEASES 7099 \| TLR4 \| DISEASES 8200 \| GDF5 \| DISEASES 659 \| BMPR2 \| DISEASES 1302 \| COL11A2 \| DISEASES 54829 \| ASPN \| DISEASES 56243 \| KIAA1217 \| DISEASES 650 \| BMP2 \| DISEASES 6239 \| RREB1 \| DISEASES 1280 \| COL2A1 \| DISEASES 10522 \| DEAF1 \| DISEASES 6736 \| SRY \| DISEASES 11173 \| ADAMTS7 \| DISEASES 5799 \| PTPRN2 \| DISEASES 11202 \| KLK8 \| DISEASES 2596 \| GAP43 \| DISEASES 6164 \| RPL34 \| DISEASES 655 \| BMP7 \| DISEASES 4784 \| NFIX \| DISEASES 5075 \| PAX1 \| DISEASES 81539 \| SLC38A1 \| DISEASES 176 \| ACAN \| DISEASES 7311 \| UBA52 \| DISEASES 1029 \| CDKN2A \| DISEASES 26354 \| GNL3 \| DISEASES 6660 \| SOX5 \| DISEASES 79831 \| KDM8 \| DISEASES 960 \| CD44 \| DISEASES 7124 \| TNF \| DISEASES 6474 \| SHOX2 \| DISEASES 389549 \| FEZF1 \| DISEASES 3712 \| IVD \| DISEASES 81792 \| ADAMTS12 \| DISEASES 3551 \| IKBKB \| DISEASES 8284 \| KDM5D \| DISEASES 7421 \| VDR \| DISEASES 4293 \| MAP3K9 \| DISEASES 8742 \| TNFSF12 \| DISEASES 732275 \| LINC00917 \| DISEASES 104054213 \| LINC01562 \| DISEASES
Locus	(Waiting for update.)

Disease ID	673
Disease	degenerative disc disease
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:15) HP:0012531 \| Pain \| 29 HP:0003418 \| Back pain \| 21 HP:0003419 \| Low back pain \| 15 HP:0002196 \| Myelopathy \| 3 HP:0002025 \| Narrowing of anal opening \| 2 HP:0003416 \| Spinal canal stenosis \| 2 HP:0030833 \| Neck pain \| 2 HP:0002758 \| Osteoarthritis \| 1 HP:0003302 \| Spondylolithesis \| 1 HP:0000969 \| Dropsy \| 1 HP:0002808 \| Gibbus deformity \| 1 HP:0012532 \| Chronic pain \| 1 HP:0004610 \| Narrow lumbar spinal canal \| 1 HP:0002176 \| Spinal cord compression \| 1 HP:0002948 \| Fusion of vertebral bodies \| 1

Disease ID	673
Disease	degenerative disc disease
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0030193 \| pain \| 29 C0037928 \| myelopathy \| 3

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:11)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs11969002	22993228	100294145	LOC100294145	umls:C0158266	GWASCAT	Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.	0.12	2013	NA	6	32891971	G	A
rs2292657	23792102	4803	NGF	umls:C0158266	BeFree	The rs4076018 SNP of NGFB was highly significant (p<.01) and rs2292657 SNP of GLI1 was significantly (p<.05) correlated to disc degeneration.	0.080271442	2013	GLI1	12	57466149	G	A
rs2292657	23792102	2735	GLI1	umls:C0158266	BeFree	The rs4076018 SNP of NGFB was highly significant (p<.01) and rs2292657 SNP of GLI1 was significantly (p<.05) correlated to disc degeneration.	0.000271442	2013	GLI1	12	57466149	G	A
rs3749982	22993228	100294145	LOC100294145	umls:C0158266	GWASCAT	Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.	0.12	2013	LOC100294145	6	32894830	T	A
rs4076018	23792102	4803	NGF	umls:C0158266	BeFree	The rs4076018 SNP of NGFB was highly significant (p<.01) and rs2292657 SNP of GLI1 was significantly (p<.05) correlated to disc degeneration.	0.080271442	2013	NGF	1	115300189	A	T
rs4076018	23792102	2735	GLI1	umls:C0158266	BeFree	The rs4076018 SNP of NGFB was highly significant (p<.01) and rs2292657 SNP of GLI1 was significantly (p<.05) correlated to disc degeneration.	0.000271442	2013	NGF	1	115300189	A	T
rs4875102	22993228	64478	CSMD1	umls:C0158266	GWASCAT	Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.	0.12	2013	CSMD1	8	4427170	G	A
rs7744666	22993228	100294145	LOC100294145	umls:C0158266	GWASCAT	Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.	0.12	2013	NA	6	32891935	T	C
rs926849	22993228	5071	PARK2	umls:C0158266	GWASCAT	Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.	0.120271442	2013	PARK2	6	161740587	C	T
rs9301951	22993228	10082	GPC6	umls:C0158266	GWASCAT	Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.	0.12	2013	GPC6	13	94300578	T	C
rs9469300	22993228	100294145	LOC100294145	umls:C0158266	GWASCAT	Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.	0.12	2013	LOC100294145	6	32892975	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:46)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	42091708	rs1109255	C	T	rs1109255	24216480	5.45E-04	Allelic	NA	NA	366 Japanese ancestry cases; 3,331 Japanese ancestry controls	Japanese(3697)	ALL(3697)	ASN(3697)	ALL(3697)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	NA	Research Support, Non-U.S. Gov't	A	HIVEP3
2	175594381	rs2646143	A	G	rs2646143	24216480	2.54E-04	Allelic	NA	NA	366 Japanese ancestry cases; 3,331 Japanese ancestry controls	Japanese(3697)	ALL(3697)	ASN(3697)	ALL(3697)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	NA	Research Support, Non-U.S. Gov't	A	NA
2	218354130	rs874840	C	T	rs874840	24216480	3.92E-04	Allelic	NA	NA	366 Japanese ancestry cases; 3,331 Japanese ancestry controls	Japanese(3697)	ALL(3697)	ASN(3697)	ALL(3697)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	NA	Research Support, Non-U.S. Gov't	T	DIRC3
3	3679852	rs17034687	C	G	rs17034687	22993228	2.00E-09	NA	0.23	[0.16-0.30] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs17034687-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	5188246	rs11918654	T	C	rs11918654	22993228	7.00E-06	NA	0.11	[0.063-0.157] unit decrease	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs11918654-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	29154358	rs613516	A	G	rs613516	24216480	8.26E-05	Allelic	NA	NA	366 Japanese ancestry cases; 3,331 Japanese ancestry controls	Japanese(3697)	ALL(3697)	ASN(3697)	ALL(3697)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	NA	Research Support, Non-U.S. Gov't	T	NA
6	11943526	rs1205863	T	G	rs1205863	22993228	6.00E-06	NA	0.21	[0.12-0.30] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs1205863-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	32852647	rs2187689	T	C	rs2187689	22993228	3.00E-08	NA	0.23	[0.15-0.31] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs2187689-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	32854697	rs10046257	G	A	rs10046257	22993228	3.00E-07	NA	0.19	[0.12-0.26] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs10046257-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	32855717	rs6457690	G	A	rs6457690	22993228	9.00E-08	NA	0.19	[0.12-0.26] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs6457690-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	32856381	rs1029296	T	C	rs1029296	22993228	9.00E-08	NA	0.19	[0.12-0.26] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs1029296-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	32856482	rs1029295	T	C	rs1029295	22993228	5.00E-07	NA	0.19	[0.12-0.26] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs1029295-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	32856934	rs6936004	T	C	rs6936004	22993228	1.00E-07	NA	0.19	[0.12-0.26] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs6936004-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	32857419	rs10214886	T	A	rs10214886	22993228	2.00E-07	NA	0.19	[0.12-0.26] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs10214886-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	32859712	rs7744666	T	C	rs7744666	22993228	6.00E-08	NA	0.2	[0.13-0.27] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs7744666-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	32859748	rs11969002	G	A	rs11969002	22993228	6.00E-08	NA	0.2	[0.13-0.27] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs11969002-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	32860752	rs9469300	G	A	rs9469300	22993228	1.00E-07	NA	0.19	[0.12-0.26] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs9469300-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	32862607	rs3749982	T	A	rs3749982	22993228	1.00E-07	NA	0.19	[0.12-0.26] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs3749982-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	56207337	rs6459154	C	T	rs6459154	24216480	2.15E-05	Recessive	NA	NA	366 Japanese ancestry cases; 3,331 Japanese ancestry controls	Japanese(3697)	ALL(3697)	ASN(3697)	ALL(3697)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	NA	Research Support, Non-U.S. Gov't	C	NA
6	65635923	rs11754641	C	G	rs11754641	22993228	8.00E-06	NA	0.29	[0.16-0.42] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs11754641-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	114017133	rs9488238	A	G	rs9488238	22993228	5.00E-06	NA	0.28	[0.16-0.40] unit decrease	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs9488238-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	162161619	rs926849	C	T	rs926849	22993228	3.00E-08	NA	0.13	[0.083-0.177] unit decrease	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs926849-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	169463101	rs9689200	A	G	rs9689200	24216480	9.98E-04	Allelic	NA	NA	366 Japanese ancestry cases; 3,331 Japanese ancestry controls	Japanese(3697)	ALL(3697)	ASN(3697)	ALL(3697)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	NA	Research Support, Non-U.S. Gov't	A	NA
7	19541920	rs7810842	C	T	rs7810842	24216480	1.75E-05	Dominant	NA	NA	366 Japanese ancestry cases; 3,331 Japanese ancestry controls	Japanese(3697)	ALL(3697)	ASN(3697)	ALL(3697)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	NA	Research Support, Non-U.S. Gov't	T	NA
7	38474750	rs973527	T	C	rs973527	24216480	2.14E-04	Dominant	NA	NA	366 Japanese ancestry cases; 3,331 Japanese ancestry controls	Japanese(3697)	ALL(3697)	ASN(3697)	ALL(3697)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	NA	Research Support, Non-U.S. Gov't	T	AMPH
8	4282618	rs980238	C	A	rs980238	22993228	9.00E-06	NA	0.1	[0.055-0.145] unit decrease	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs980238-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
8	4284692	rs4875102	G	A	rs4875102	22993228	4.00E-07	NA	0.12	[0.073-0.167] unit decrease	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs4875102-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
8	4285390	rs1154053	G	C	rs1154053	22993228	4.00E-06	NA	0.13	[0.075-0.185] unit decrease	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs1154053-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
8	4404738	rs17344217	T	G	rs17344217	24216480	1.44E-04	Recessive	NA	NA	366 Japanese ancestry cases; 3,331 Japanese ancestry controls	Japanese(3697)	ALL(3697)	ASN(3697)	ALL(3697)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	NA	Research Support, Non-U.S. Gov't	T	CSMD1
8	92559915	rs2657195	A	G	rs2657195	22993228	8.00E-06	NA	0.13	[0.075-0.185] unit decrease	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs2657195-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	3155173	rs7896691	C	T	rs7896691	22993228	2.00E-06	NA	0.17	[0.10-0.24] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs7896691-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	31495974	rs1250307	G	A	rs1250307	22993228	4.00E-06	NA	0.68	[0.39-0.97] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs1250307-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	31512098	rs2484992	T	C	rs2484992	22993228	5.00E-06	NA	0.68	[0.39-0.97] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs2484992-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	31515132	rs2484990	T	C	rs2484990	22993228	4.00E-06	NA	0.68	[0.39-0.97] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs2484990-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	70626429	rs10998466	A	G	rs10998466	22993228	4.00E-06	NA	0.53	[0.31-0.75] unit decrease	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs10998466-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	73778267	rs1245582	C	T	rs1245582	24216480	1.00E-06	East Asians	NA	NA	366 Japanese ancestry cases; 3,331 Japanese ancestry controls	Japanese(3697)	ALL(3697)	ASN(3697)	ALL(3697)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	NA	Research Support, Non-U.S. Gov't	A	NA
10	73778267	rs1245582	C	T	rs1245582	24216480	4.00E-08	NA	1.2	[1.13-1.29]	366 Japanese ancestry cases; 3,331 Japanese ancestry controls	Japanese(3697)	ALL(3697)	ASN(3697)	ALL(3697)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	NA	Research Support, Non-U.S. Gov't	A	NA
11	103525754	rs7118412	A	G	rs7118412	22993228	9.00E-06	NA	0.09	[0.049-0.131] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs7118412-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
11	103526024	rs7103004	C	T	rs7103004	22993228	9.00E-06	NA	0.09	[0.049-0.131] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs7103004-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
11	103529632	rs12805875	A	G	rs12805875	22993228	9.00E-06	NA	0.09	[0.05-0.13] unit increse	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs12805875-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
11	103530366	rs4554859	G	T	rs4554859	22993228	9.00E-06	NA	0.09	[0.049-0.131] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs4554859-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
13	94952832	rs9301951	T	C	rs9301951	22993228	9.00E-07	NA	0.26	[0.15-0.37] unit decrease	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs9301951-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
16	630665	rs1981483	G	A	rs1981483	22993228	4.00E-06	NA	0.11	[0.065-0.155] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs1981483-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
16	637212	rs2017567	T	C	rs2017567	22993228	9.00E-06	NA	0.1	[0.059-0.141] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs2017567-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
16	661335	rs7204439	T	C	rs7204439	22993228	4.00E-06	NA	0.11	[0.065-0.155] unit increase	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs7204439-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
19	50721074	rs4802666	G	A	rs4802666	22993228	5.00E-06	NA	0.13	[0.073-0.187] unit decrease	4,683 European ancestry individuals	European(4683)	ALL(4683)	EUR(4683)	ALL(4683)	Disc degeneration (lumbar)	HPOID:0008419	Intervertebral disc degeneration	DOID:0080007	bone deterioration disease	D055959	Intervertebral Disc Degeneration	EFOID:0004994	lumbar disc degeneration	Bone disease	rs4802666-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0158266	nicotine	D009538	-	intervertebral disc degeneration	MESH:D055959	marker/mechanism	11484105

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)