PedAM
Pediatric Disease Annotations & Medicines
| cytomegalovirus retinitis | ||||
| Disease ID | 781 |
|---|---|
| Disease | cytomegalovirus retinitis |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:17) HP:0002721 | Immunodeficiency | 7 HP:0000518 | Cataract | 1 HP:0011505 | Cystoid macular edema | 1 HP:0012089 | Arteritis | 1 HP:0000541 | Detached retina | 1 HP:0006775 | Multiple myeloma | 1 HP:0012189 | Hodgkin disease | 1 HP:0000822 | Hypertension | 1 HP:0002090 | Pneumonia | 1 HP:0000554 | Uveitis | 1 HP:0000505 | Poor vision | 1 HP:0100653 | Optic neuritis | 1 HP:0007985 | Retinal arteriolar occlusion | 1 HP:0100726 | Kaposi's sarcoma | 1 HP:0007902 | Vitreous hemorrhage | 1 HP:0000572 | Visual loss | 1 HP:0000618 | Blindness | 1 |
| Disease ID | 781 |
|---|---|
| Disease | cytomegalovirus retinitis |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:13) C1963266 | uveitis C1963229 | retinal detachment C1532529 | frosted branch angiitis C0456909 | vision loss C0426768 | o sign C0235812 | vitritis C0221027 | good's syndrome C0035321 | retinal tears C0035305 | retinal detachments C0031129 | periphlebitis C0028841 | ocular hypotony C0024440 | cystoid macular edema C0019080 | hemorrhage |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:5) C0019080 | hemorrhage | 1 C0035305 | retinal detachment | 1 C0042164 | uveitis | 1 C0024440 | cystoid macular edema | 1 C0221027 | good's syndrome | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:3) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs2228055 | 20617924 | 3587 | IL10RA | umls:C0206178 | BeFree | In European Americans (n = 750), a haplotype carrying an amino acid changing variation in the cytoplasmic domain (S420L) of IL-10R1 can be protective (OR, 0.14; 95% CI, 0.02-0.94; P = .04) against, whereas another haplotype carrying an amino acid changing variation in the extracellular domain (I224V) of IL-10R1 can be more susceptible (OR, 6.21; 95% CI, 1.22- 31.54; P = .03) to CMV retinitis. | 0.002638474 | 2010 | IL10RA | 11 | 117994131 | A | G |
| rs2229114 | 20617924 | 3587 | IL10RA | umls:C0206178 | BeFree | In European Americans (n = 750), a haplotype carrying an amino acid changing variation in the cytoplasmic domain (S420L) of IL-10R1 can be protective (OR, 0.14; 95% CI, 0.02-0.94; P = .04) against, whereas another haplotype carrying an amino acid changing variation in the extracellular domain (I224V) of IL-10R1 can be more susceptible (OR, 6.21; 95% CI, 1.22- 31.54; P = .03) to CMV retinitis. | 0.002638474 | 2010 | IL10RA | 11 | 117999163 | C | T |
| rs386479044 | 20617924 | 3587 | IL10RA | umls:C0206178 | BeFree | In European Americans (n = 750), a haplotype carrying an amino acid changing variation in the cytoplasmic domain (S420L) of IL-10R1 can be protective (OR, 0.14; 95% CI, 0.02-0.94; P = .04) against, whereas another haplotype carrying an amino acid changing variation in the extracellular domain (I224V) of IL-10R1 can be more susceptible (OR, 6.21; 95% CI, 1.22- 31.54; P = .03) to CMV retinitis. | 0.002638474 | 2010 | NA | NA | NA | NA | NA |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:4) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0206178 | cidofovir | C059262 | 113852-37-2 | cytomegalovirus retinitis | MESH:D017726 | therapeutic | 9525435 | ||
| C0206178 | cyclophosphamide | D003520 | 50-18-0 | cytomegalovirus retinitis | MESH:D017726 | marker/mechanism | 12488280 | ||
| C0206178 | foscarnet | D017245 | 4428-95-9 | cytomegalovirus retinitis | MESH:D017726 | therapeutic | 11363124 | ||
| C0206178 | ganciclovir | D015774 | 82410-32-0 | cytomegalovirus retinitis | MESH:D017726 | therapeutic | 11363124 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |