PedAM

Pediatric Disease Annotations & Medicines


	cutaneous t cell lymphoma

Disease ID	349
Disease	cutaneous t cell lymphoma
Definition	A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.
Synonym	cells cutaneous lymphomas t ctcl ctcl - cutaneous t-cell lymphoma cutaneous t-cell lymphoma cutaneous t-cell lymphoma (morphologic abnormality) cutaneous t-cell lymphoma, no icd-o subtype cutaneous t-cell lymphoma, no icd-o subtype (morphologic abnormality) cutaneous t-cell lymphoma, no international classification of diseases for oncology subtype cutaneous t-cell lymphoma, no international classification of diseases for oncology subtype (morphologic abnormality) cutaneous t-cell lymphomas cutaneous t-cell non-hodgkin lymphoma cutaneous t-cell non-hodgkin's lymphoma lymphoma, cutaneous t-cell lymphoma, t cell, cutaneous lymphoma, t-cell, cutaneous lymphoma, t-cell, cutaneous [disease/finding] lymphomas, cutaneous t-cell primary cutaneous t-cell lymphoma primary cutaneous t-cell lymphoma (disorder) primary cutaneous t-cell non-hodgkin's lymphoma skin t-cell non-hodgkin's lymphoma t cell cutaneous lymphoma t cell lymphoma, cutaneous t-cell cutaneous lymphoma t-cell lymphoma, cutaneous t-cell lymphomas, cutaneous t-cell non-hodgkin's lymphoma of skin t-cell non-hodgkin's lymphoma of the skin
Orphanet	ORPHANET:171901
DOID	DOID:0060061
UMLS	C0079773
MeSH	D016410
SNOMED-CT	SNOMEDCT_US_2016_09_01:400122007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:4) C0020757 \| ichthyosis \| 1 C0263505 \| alopecia universalis \| 1 C0020758 \| congenital ichthyosis \| 1 C0002170 \| alopecia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:21) STAT5B \| 6777 \| CTD_human MCL1 \| 4170 \| CTD_human TP53 \| 7157 \| CTD_human FAS \| 355 \| CTD_human CTLA4 \| 1493 \| CTD_human DNMT3A \| 1788 \| CTD_human TNFAIP3 \| 7128 \| CTD_human IRF4 \| 3662 \| CTD_human NFKB2 \| 4791 \| CTD_human BRAF \| 673 \| CTD_human CARD11 \| 84433 \| CTD_human ARID1A \| 8289 \| CTD_human CDKN2A \| 1029 \| CTD_human BAX \| 581 \| CTD_human CD28 \| 940 \| CTD_human CTCF \| 10664 \| CTD_human PRKCQ \| 5588 \| CTD_human PLCG1 \| 5335 \| CTD_human ATM \| 472 \| CTD_human RHOA \| 387 \| CTD_human ZEB1 \| 6935 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 1906 \| EDN1 \| infer 3569 \| IL6 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:330) 100628315 \| DNM3OS \| DISEASES 57646 \| USP28 \| DISEASES 6362 \| CCL18 \| DISEASES 10344 \| CCL26 \| DISEASES 51564 \| HDAC7 \| DISEASES 933 \| CD22 \| DISEASES 3385 \| ICAM3 \| DISEASES 602 \| BCL3 \| DISEASES 9319 \| TRIP13 \| DISEASES 4335 \| MNT \| DISEASES 9274 \| BCL7C \| DISEASES 3560 \| IL2RB \| DISEASES 3002 \| GZMB \| DISEASES 64743 \| WDR13 \| DISEASES 6367 \| CCL22 \| DISEASES 6361 \| CCL17 \| DISEASES 973 \| CD79A \| DISEASES 4818 \| NKG7 \| DISEASES 9527 \| GOSR1 \| DISEASES 3558 \| IL2 \| DISEASES 969 \| CD69 \| DISEASES 51561 \| IL23A \| DISEASES 3458 \| IFNG \| DISEASES 4188 \| MDFI \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 604 \| BCL6 \| DISEASES 11126 \| CD160 \| DISEASES 6402 \| SELL \| DISEASES 3070 \| HELLS \| DISEASES 4360 \| MRC1 \| DISEASES 8743 \| TNFSF10 \| DISEASES 7291 \| TWIST1 \| DISEASES 5335 \| PLCG1 \| DISEASES 1088 \| CEACAM8 \| DISEASES 10893 \| MMP24 \| DISEASES 1236 \| CCR7 \| DISEASES 30848 \| CTAG2 \| DISEASES 968 \| CD68 \| DISEASES 1036 \| CDO1 \| DISEASES 2872 \| MKNK2 \| DISEASES 4277 \| MICB \| DISEASES 83483 \| PLVAP \| DISEASES 3727 \| JUND \| DISEASES 8666 \| EIF3G \| DISEASES 10752 \| CHL1 \| DISEASES 29969 \| MDFIC \| DISEASES 3569 \| IL6 \| DISEASES 9238 \| TBRG4 \| DISEASES 6366 \| CCL21 \| DISEASES 10850 \| CCL27 \| DISEASES 9099 \| USP2 \| DISEASES 10113 \| PREB \| DISEASES 5862 \| RAB2A \| DISEASES 1031 \| CDKN2C \| DISEASES 5264 \| PHYH \| DISEASES 3682 \| ITGAE \| DISEASES 5588 \| PRKCQ \| DISEASES 3552 \| IL1A \| DISEASES 3574 \| IL7 \| DISEASES 10578 \| GNLY \| DISEASES 8491 \| MAP4K3 \| DISEASES 943 \| TNFRSF8 \| DISEASES 9262 \| STK17B \| DISEASES 51192 \| CKLF \| DISEASES 867 \| CBL \| DISEASES 10382 \| TUBB4A \| DISEASES 941 \| CD80 \| DISEASES 5709 \| PSMD3 \| DISEASES 6774 \| STAT3 \| DISEASES 3383 \| ICAM1 \| DISEASES 8395 \| PIP5K1B \| DISEASES 27074 \| LAMP3 \| DISEASES 54806 \| AHI1 \| DISEASES 939 \| CD27 \| DISEASES 7112 \| TMPO \| DISEASES 3695 \| ITGB7 \| DISEASES 23344 \| ESYT1 \| DISEASES 54509 \| RHOF \| DISEASES 597 \| BCL2A1 \| DISEASES 3687 \| ITGAX \| DISEASES 146225 \| CMTM2 \| DISEASES 7157 \| TP53 \| DISEASES 207 \| AKT1 \| DISEASES 1939 \| EIF2D \| DISEASES 9180 \| OSMR \| DISEASES 3001 \| GZMA \| DISEASES 1030 \| CDKN2B \| DISEASES 3439 \| IFNA1 \| DISEASES 4851 \| NOTCH1 \| DISEASES 4253 \| CTAGE5 \| DISEASES 7424 \| VEGFC \| DISEASES 5805 \| PTS \| DISEASES 2043 \| EPHA4 \| DISEASES 4154 \| MBNL1 \| DISEASES 7070 \| THY1 \| DISEASES 7345 \| UCHL1 \| DISEASES 9337 \| CNOT8 \| DISEASES 5922 \| RASA2 \| DISEASES 10563 \| CXCL13 \| DISEASES 9530 \| BAG4 \| DISEASES 5468 \| PPARG \| DISEASES 9437 \| NCR1 \| DISEASES 643 \| CXCR5 \| DISEASES 1234 \| CCR5 \| DISEASES 6777 \| STAT5B \| DISEASES 10630 \| PDPN \| DISEASES 7412 \| VCAM1 \| DISEASES 2215 \| FCGR3B \| DISEASES 79885 \| HDAC11 \| DISEASES 308 \| ANXA5 \| DISEASES 3600 \| IL15 \| DISEASES 1437 \| CSF2 \| DISEASES 116379 \| IL22RA2 \| DISEASES 9265 \| CYTH3 \| DISEASES 10922 \| FASTK \| DISEASES 139324 \| HDX \| DISEASES 10206 \| TRIM13 \| DISEASES 4108 \| MAGEA9 \| DISEASES 201161 \| CENPV \| DISEASES 6778 \| STAT6 \| DISEASES 94235 \| GNG8 \| DISEASES 353514 \| LILRA5 \| DISEASES 3868 \| KRT16 \| DISEASES 55106 \| SLFN12 \| DISEASES 598 \| BCL2L1 \| DISEASES 3603 \| IL16 \| DISEASES 8841 \| HDAC3 \| DISEASES 3689 \| ITGB2 \| DISEASES 3688 \| ITGB1 \| DISEASES 28511 \| NKIRAS2 \| DISEASES 1493 \| CTLA4 \| DISEASES 121355 \| GTSF1 \| DISEASES 171558 \| PTCRA \| DISEASES 57215 \| THAP11 \| DISEASES 3596 \| IL13 \| DISEASES 3627 \| CXCL10 \| DISEASES 6504 \| SLAMF1 \| DISEASES 6373 \| CXCL11 \| DISEASES 3622 \| ING2 \| DISEASES 27087 \| B3GAT1 \| DISEASES 1938 \| EEF2 \| DISEASES 5897 \| RAG2 \| DISEASES 8763 \| CD164 \| DISEASES 3265 \| HRAS \| DISEASES 947 \| CD34 \| DISEASES 836 \| CASP3 \| DISEASES 924 \| CD7 \| DISEASES 5553 \| PRG2 \| DISEASES 8837 \| CFLAR \| DISEASES 23166 \| STAB1 \| DISEASES 80169 \| CTC1 \| DISEASES 666 \| BOK \| DISEASES 1191 \| CLU \| DISEASES 30835 \| CD209 \| DISEASES 6773 \| STAT2 \| DISEASES 10859 \| LILRB1 \| DISEASES 10458 \| BAIAP2 \| DISEASES 57381 \| RHOJ \| DISEASES 274 \| BIN1 \| DISEASES 4026 \| LPP \| DISEASES 4684 \| NCAM1 \| DISEASES 10726 \| NUDC \| DISEASES 10938 \| EHD1 \| DISEASES 6863 \| TAC1 \| DISEASES 3909 \| LAMA3 \| DISEASES 9235 \| IL32 \| DISEASES 3812 \| KIR3DL2 \| DISEASES 1237 \| CCR8 \| DISEASES 63891 \| RNF123 \| DISEASES 4601 \| MXI1 \| DISEASES 147968 \| CAPN12 \| DISEASES 6401 \| SELE \| DISEASES 942 \| CD86 \| DISEASES 1485 \| CTAG1B \| DISEASES 1233 \| CCR4 \| DISEASES 25901 \| CCDC28A \| DISEASES 344018 \| FIGLA \| DISEASES 10013 \| HDAC6 \| DISEASES 3320 \| HSP90AA1 \| DISEASES 3802 \| KIR2DL1 \| DISEASES 80323 \| CCDC68 \| DISEASES 112744 \| IL17F \| DISEASES 3932 \| LCK \| DISEASES 10608 \| MXD4 \| DISEASES 3824 \| KLRD1 \| DISEASES 8631 \| SKAP1 \| DISEASES 23583 \| SMUG1 \| DISEASES 4602 \| MYB \| DISEASES 115362 \| GBP5 \| DISEASES 6776 \| STAT5A \| DISEASES 259197 \| NCR3 \| DISEASES 3804 \| KIR2DL3 \| DISEASES 921 \| CD5 \| DISEASES 3716 \| JAK1 \| DISEASES 3605 \| IL17A \| DISEASES 56940 \| DUSP22 \| DISEASES 80705 \| TSGA10 \| DISEASES 8764 \| TNFRSF14 \| DISEASES 355 \| FAS \| DISEASES 5358 \| PLS3 \| DISEASES 140885 \| SIRPA \| DISEASES 3683 \| ITGAL \| DISEASES 64919 \| BCL11B \| DISEASES 51390 \| AIG1 \| DISEASES 4111 \| MAGEA12 \| DISEASES 5887 \| RAD23B \| DISEASES 5079 \| PAX5 \| DISEASES 26052 \| DNM3 \| DISEASES 6775 \| STAT4 \| DISEASES 841 \| CASP8 \| DISEASES 2526 \| FUT4 \| DISEASES 6364 \| CCL20 \| DISEASES 9332 \| CD163 \| DISEASES 2547 \| XRCC6 \| DISEASES 7037 \| TFRC \| DISEASES 6693 \| SPN \| DISEASES 170482 \| CLEC4C \| DISEASES 4311 \| MME \| DISEASES 1803 \| DPP4 \| DISEASES 54106 \| TLR9 \| DISEASES 6772 \| STAT1 \| DISEASES 6935 \| ZEB1 \| DISEASES 259230 \| SGMS1 \| DISEASES 9760 \| TOX \| DISEASES 4283 \| CXCL9 \| DISEASES 7107 \| GPR137B \| DISEASES 142 \| PARP1 \| DISEASES 3664 \| IRF6 \| DISEASES 80342 \| TRAF3IP3 \| DISEASES 5788 \| PTPRC \| DISEASES 84946 \| LTV1 \| DISEASES 51696 \| HECA \| DISEASES 356 \| FASLG \| DISEASES 55811 \| ADCY10 \| DISEASES 2214 \| FCGR3A \| DISEASES 253582 \| TMEM244 \| DISEASES 115352 \| FCRL3 \| DISEASES 6278 \| S100A7 \| DISEASES 6280 \| S100A9 \| DISEASES 7062 \| TCHH \| DISEASES 4942 \| OAT \| DISEASES 4170 \| MCL1 \| DISEASES 5406 \| PNLIP \| DISEASES 914 \| CD2 \| DISEASES 6847 \| SYCP1 \| DISEASES 4791 \| NFKB2 \| DISEASES 959 \| CD40LG \| DISEASES 1791 \| DNTT \| DISEASES 23626 \| SPO11 \| DISEASES 51213 \| LUZP4 \| DISEASES 5728 \| PTEN \| DISEASES 958 \| CD40 \| DISEASES 100 \| ADA \| DISEASES 9436 \| NCR2 \| DISEASES 3065 \| HDAC1 \| DISEASES 55869 \| HDAC8 \| DISEASES 2833 \| CXCR3 \| DISEASES 3561 \| IL2RG \| DISEASES 1043 \| CD52 \| DISEASES 6257 \| RXRB \| DISEASES 50943 \| FOXP3 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 386653 \| IL31 \| DISEASES 4609 \| MYC \| DISEASES 10497 \| UNC13B \| DISEASES 64225 \| ATL2 \| DISEASES 9308 \| CD83 \| DISEASES 7293 \| TNFRSF4 \| DISEASES 2625 \| GATA3 \| DISEASES 10631 \| POSTN \| DISEASES 3559 \| IL2RA \| DISEASES 79886 \| CAAP1 \| DISEASES 4507 \| MTAP \| DISEASES 3440 \| IFNA2 \| DISEASES 1107 \| CHD3 \| DISEASES 51284 \| TLR7 \| DISEASES 3662 \| IRF4 \| DISEASES 2315 \| MLANA \| DISEASES 29126 \| CD274 \| DISEASES 51378 \| ANGPT4 \| DISEASES 6624 \| FSCN1 \| DISEASES 201633 \| TIGIT \| DISEASES 238 \| ALK \| DISEASES 64693 \| CTAGE1 \| DISEASES 3811 \| KIR3DL1 \| DISEASES 4216 \| MAP3K4 \| DISEASES 10018 \| BCL2L11 \| DISEASES 9349 \| RPL23 \| DISEASES 6387 \| CXCL12 \| DISEASES 56666 \| PANX2 \| DISEASES 84433 \| CARD11 \| DISEASES 3676 \| ITGA4 \| DISEASES 26292 \| MYCBP \| DISEASES 7110 \| TMF1 \| DISEASES 7748 \| ZNF195 \| DISEASES 50489 \| CD207 \| DISEASES 3384 \| ICAM2 \| DISEASES 3718 \| JAK3 \| DISEASES 1029 \| CDKN2A \| DISEASES 147920 \| IGFL2 \| DISEASES 3430 \| IFI35 \| DISEASES 3550 \| IK \| DISEASES 7124 \| TNF \| DISEASES 6304 \| SATB1 \| DISEASES 7072 \| TIA1 \| DISEASES 54900 \| LAX1 \| DISEASES 9734 \| HDAC9 \| DISEASES 3586 \| IL10 \| DISEASES 5527 \| PPP2R5C \| DISEASES 133396 \| IL31RA \| DISEASES 4193 \| MDM2 \| DISEASES 338376 \| IFNE \| DISEASES 5793 \| PTPRG \| DISEASES 65980 \| BRD9 \| DISEASES 30816 \| ERVW-1 \| DISEASES 1452 \| CSNK1A1 \| DISEASES 8667 \| EIF3H \| DISEASES 3066 \| HDAC2 \| DISEASES 930 \| CD19 \| DISEASES 387357 \| THEMIS \| DISEASES 1232 \| CCR3 \| DISEASES 3684 \| ITGAM \| DISEASES 605 \| BCL7A \| DISEASES 89795 \| NAV3 \| DISEASES 567 \| B2M \| DISEASES 284340 \| CXCL17 \| DISEASES 100302740 \| FAS-AS1 \| DISEASES 100126781 \| SNAR-F \| DISEASES 26801 \| SNORD48 \| DISEASES
Locus	(Waiting for update.)

Disease ID	349
Disease	cutaneous t cell lymphoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:7) HP:0002664 \| Neoplasia \| 2 HP:0008064 \| Ichthyosis \| 1 HP:0000989 \| pruritis \| 1 HP:0001596 \| Hair loss \| 1 HP:0007431 \| Congenital ichthyosis \| 1 HP:0001019 \| Exfoliative dermititis \| 1 HP:0002289 \| Alopecia, complete \| 1

Disease ID	349
Disease	cutaneous t cell lymphoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:15) C2364133 \| infection C0702102 \| arthritis mutilans C0343888 \| cutaneous cryptococcosis C0162323 \| polyarthritis C0085077 \| sweet's syndrome C0037284 \| skin lesions C0032285 \| pneumoniae C0029166 \| oral manifestations C0022504 \| kaposi's varicelliform eruption C0020676 \| hypothyroidism C0020097 \| htlv-i C0017661 \| iga nephropathy C0007682 \| central nervous system disease C0007137 \| squamous cell carcinoma C0003864 \| arthritis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0037284 \| skin lesions \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:8)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0079773	arsenic trioxide	C006632	1327-53-3	lymphoma, t-cell, cutaneous	MESH:D016410	therapeutic	14632209
C0079773	bexarotene	C095105	-	lymphoma, t-cell, cutaneous	MESH:D016410	therapeutic	11161223
C0079773	cladribine	D017338	4291-63-8	lymphoma, t-cell, cutaneous	MESH:D016410	therapeutic	7948311
C0079773	methotrexate	D008727	1959/5/2	lymphoma, t-cell, cutaneous	MESH:D016410	therapeutic	10233644
C0079773	methoxsalen	D008730	298-81-7	lymphoma, t-cell, cutaneous	MESH:D016410	therapeutic	17003103
C0079773	romidepsin	C087123	-	lymphoma, t-cell, cutaneous	MESH:D016410	therapeutic	21417297
C0079773	vorinostat	C111237	-	lymphoma, t-cell, cutaneous	MESH:D016410	marker/mechanism	20479100
C0079773	vorinostat	C111237	-	lymphoma, t-cell, cutaneous	MESH:D016410	therapeutic	21417297

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
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