PedAM

Pediatric Disease Annotations & Medicines


	cutaneous lupus erythematosus

Disease ID	317
Disease	cutaneous lupus erythematosus
Definition	A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).
Synonym	cutaneous lupus erythematosus (disorder) cutaneous lupus erythematosus, nos lupus erythematosus, cutaneous lupus erythematosus, cutaneous [disease/finding]
Orphanet	ORPHANET:535
DOID	DOID:0050169
UMLS	C0024137
MeSH	D008178
SNOMED-CT	SNOMEDCT_US_2016_09_01:7119001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:11) C0024141 \| systemic lupus erythematosus \| 3 C0409974 \| lupus erythematosus \| 2 C0022658 \| renal disease \| 1 C0042384 \| vasculitis \| 1 C0011603 \| dermatitis \| 1 C0042870 \| vitamin d deficiency \| 1 C0006663 \| calcinosis \| 1 C0026272 \| mixed connective tissue disease \| 1 C0042870 \| vitamin d defic \| 1 C0151436 \| leukocytoclastic vasculitis \| 1 C0009782 \| connective tissue disease \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:109) 3002 \| GZMB \| DISEASES 479 \| ATP12A \| DISEASES 973 \| CD79A \| DISEASES 727 \| C5 \| DISEASES 6346 \| CCL1 \| DISEASES 3458 \| IFNG \| DISEASES 27434 \| POLM \| DISEASES 5552 \| SRGN \| DISEASES 970 \| CD70 \| DISEASES 718 \| C3 \| DISEASES 7186 \| TRAF2 \| DISEASES 8930 \| MBD4 \| DISEASES 968 \| CD68 \| DISEASES 4277 \| MICB \| DISEASES 3866 \| KRT15 \| DISEASES 22856 \| CHSY1 \| DISEASES 6737 \| TRIM21 \| DISEASES 301 \| ANXA1 \| DISEASES 3569 \| IL6 \| DISEASES 27348 \| TOR1B \| DISEASES 10068 \| IL18BP \| DISEASES 6741 \| SSB \| DISEASES 495 \| ATP4A \| DISEASES 25939 \| SAMHD1 \| DISEASES 23523 \| CABIN1 \| DISEASES 10578 \| GNLY \| DISEASES 7297 \| TYK2 \| DISEASES 3383 \| ICAM1 \| DISEASES 311 \| ANXA11 \| DISEASES 3687 \| ITGAX \| DISEASES 5141 \| PDE4A \| DISEASES 3001 \| GZMA \| DISEASES 3439 \| IFNA1 \| DISEASES 56832 \| IFNK \| DISEASES 3176 \| HNMT \| DISEASES 3606 \| IL18 \| DISEASES 925 \| CD8A \| DISEASES 51705 \| EMCN \| DISEASES 1672 \| DEFB1 \| DISEASES 84659 \| RNASE7 \| DISEASES 717 \| C2 \| DISEASES 719 \| C3AR1 \| DISEASES 3689 \| ITGB2 \| DISEASES 3627 \| CXCL10 \| DISEASES 50515 \| CHST11 \| DISEASES 1296 \| COL8A2 \| DISEASES 3037 \| HAS2 \| DISEASES 9156 \| EXO1 \| DISEASES 1776 \| DNASE1L3 \| DISEASES 8411 \| EEA1 \| DISEASES 4026 \| LPP \| DISEASES 4684 \| NCAM1 \| DISEASES 80381 \| CD276 \| DISEASES 811 \| CALR \| DISEASES 414325 \| DEFB103A \| DISEASES 79155 \| TNIP2 \| DISEASES 55894 \| DEFB103B \| DISEASES 1237 \| CCR8 \| DISEASES 51330 \| TNFRSF12A \| DISEASES 3563 \| IL3RA \| DISEASES 340061 \| TMEM173 \| DISEASES 2242 \| FES \| DISEASES 6401 \| SELE \| DISEASES 5142 \| PDE4B \| DISEASES 1233 \| CCR4 \| DISEASES 3716 \| JAK1 \| DISEASES 3605 \| IL17A \| DISEASES 6050 \| RNH1 \| DISEASES 728 \| C5AR1 \| DISEASES 355 \| FAS \| DISEASES 5284 \| PIGR \| DISEASES 170482 \| CLEC4C \| DISEASES 4283 \| CXCL9 \| DISEASES 5867 \| RAB4A \| DISEASES 6738 \| TROVE2 \| DISEASES 356 \| FASLG \| DISEASES 6278 \| S100A7 \| DISEASES 115004 \| MB21D1 \| DISEASES 2633 \| GBP1 \| DISEASES 959 \| CD40LG \| DISEASES 680 \| BRS3 \| DISEASES 2833 \| CXCR3 \| DISEASES 4153 \| MBL2 \| DISEASES 712 \| C1QA \| DISEASES 3118 \| HLA-DQA2 \| DISEASES 4439 \| MSH5 \| DISEASES 6850 \| SYK \| DISEASES 50943 \| FOXP3 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 1041 \| CDSN \| DISEASES 56658 \| TRIM39 \| DISEASES 8718 \| TNFRSF25 \| DISEASES 9308 \| CD83 \| DISEASES 6303 \| SAT1 \| DISEASES 3456 \| IFNB1 \| DISEASES 8544 \| PIR \| DISEASES 10087 \| COL4A3BP \| DISEASES 1781 \| DYNC1I2 \| DISEASES 4599 \| MX1 \| DISEASES 93986 \| FOXP2 \| DISEASES 11277 \| TREX1 \| DISEASES 85443 \| DCLK3 \| DISEASES 720 \| C4A \| DISEASES 7124 \| TNF \| DISEASES 79897 \| RPP21 \| DISEASES 3586 \| IL10 \| DISEASES 54475 \| NLE1 \| DISEASES 721 \| C4B \| DISEASES 6625 \| SNRNP70 \| DISEASES
Locus	(Waiting for update.)

Disease ID	317
Disease	cutaneous lupus erythematosus
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:9) HP:0002725 \| Systemic lupus erythematosus \| 3 HP:0000992 \| Skin photosensitivity \| 2 HP:0100512 \| Vitamin D deficiency \| 1 HP:0007417 \| Discoid lupus erythematosus \| 1 HP:0003761 \| Calcinosis \| 1 HP:0100539 \| Periorbital swelling \| 1 HP:0000969 \| Dropsy \| 1 HP:0001581 \| Recurrent skin infections \| 1 HP:0002633 \| Vasculitis \| 1

Disease ID	317
Disease	cutaneous lupus erythematosus
Manually Symptom	UMLS \| Name(Total Manually Symptoms:9) C1963138 \| hypertension C1521999 \| acute myocardial infarction C1136085 \| monoclonal gammopathy C0543698 \| hypersensitivity syndrome C0037284 \| skin lesions C0033975 \| psychosis C0024205 \| lymphadenitis C0024141 \| systemic lupus erythematosus C0015230 \| rash
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0024141 \| systemic lupus erythematosus \| 3 C0037284 \| skin lesions \| 3

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0000992	Cutaneous photosensitivity	MP:0001202	skin photosensitivity;

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0003765	Psoriasis	MP:0003410	abnormal artery development;HP:0200042	Skin ulcer

Chemical(Total Drugs:8)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0024137	chloroquine	D002738	1954/5/7	lupus erythematosus, cutaneous	MESH:D008178	therapeutic	7873836
C0024137	cinnarizine	D002936	298-57-7	lupus erythematosus, cutaneous	MESH:D008178	marker/mechanism	9696142
C0024137	dapsone	D003622	80-08-0	lupus erythematosus, cutaneous	MESH:D008178	therapeutic	9451224
C0024137	fluorouracil	D005472	51-21-8	lupus erythematosus, cutaneous	MESH:D008178	marker/mechanism	15086387
C0024137	pimecrolimus	C117268	-	lupus erythematosus, cutaneous	MESH:D008178	therapeutic	16033622
C0024137	rifampin	D012293	13292-46-1	lupus erythematosus, cutaneous	MESH:D008178	marker/mechanism	11422169
C0024137	thalidomide	D013792	50-35-1	lupus erythematosus, cutaneous	MESH:D008178	therapeutic	11958580
C0024137	valproic acid	D014635	99-66-1	lupus erythematosus, cutaneous	MESH:D008178	marker/mechanism	19040509

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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