PedAM

Pediatric Disease Annotations & Medicines


	cutaneous leishmaniasis

Disease ID	632
Disease	cutaneous leishmaniasis
Definition	An endemic disease that is characterized by the development of single or multiple localized lesions on exposed areas of skin that typically ulcerate. The disease has been divided into Old and New World forms. Old World leishmaniasis is separated into three distinct types according to epidemiology and clinical manifestations and is caused by species of the L. tropica and L. aethiopica complexes as well as by species of the L. major genus. New World leishmaniasis, also called American leishmaniasis, occurs in South and Central America and is caused by species of the L. mexicana or L. braziliensis complexes.
Synonym	cutaneous leishmaniases cutaneous leishmaniasis (disorder) leishmaniases, cutaneous leishmaniasis cutaneous leishmaniasis, cutaneous leishmaniasis, cutaneous [disease/finding]
DOID	DOID:9111
ICD10	ICD10CM:B55.1
UMLS	C0023283
MeSH	D016773
SNOMED-CT	SNOMEDCT_US_2016_09_01:240637006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:14) C0023290 \| visceral leishmaniasis \| 2 C0038013 \| ankylosing spondylitis \| 1 C0036202 \| sarcoid \| 1 C0038012 \| spondylitis \| 1 C0013595 \| eczema \| 1 C0036920 \| sezary syndrome \| 1 C0036203 \| cutaneous sarcoid \| 1 C0041234 \| chagas disease \| 1 C0023281 \| leishmaniasis \| 1 C0030578 \| paronychia \| 1 C0001175 \| acquired immunodeficiency syndrome \| 1 C0009324 \| ulcerative colitis \| 1 C0004623 \| bacterial infection \| 1 C0009319 \| colitis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:8) TNF \| 7124 \| CTD_human IFNG \| 3458 \| CTD_human CCL2 \| 6347 \| CTD_human IL1B \| 3553 \| CTD_human MMP2 \| 4313 \| CTD_human IL10 \| 3586 \| CTD_human IL4 \| 3565 \| CTD_human CXCL8 \| 3576 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:8) 3458 \| IFNG \| infer 3586 \| IL10 \| infer 3565 \| IL4 \| infer 3569 \| IL6 \| infer 4049 \| LTA \| infer 6556 \| SLC11A1 \| infer 7097 \| TLR2 \| infer 7124 \| TNF \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:181) 3385 \| ICAM3 \| DISEASES 30009 \| TBX21 \| DISEASES 3002 \| GZMB \| DISEASES 123263 \| MTFMT \| DISEASES 2222 \| FDFT1 \| DISEASES 973 \| CD79A \| DISEASES 57817 \| HAMP \| DISEASES 6348 \| CCL3 \| DISEASES 6347 \| CCL2 \| DISEASES 3558 \| IL2 \| DISEASES 3587 \| IL10RA \| DISEASES 969 \| CD69 \| DISEASES 3458 \| IFNG \| DISEASES 55907 \| CMAS \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 6556 \| SLC11A1 \| DISEASES 23178 \| PASK \| DISEASES 6402 \| SELL \| DISEASES 23433 \| RHOQ \| DISEASES 4852 \| NPY \| DISEASES 84292 \| WDR83 \| DISEASES 5184 \| PEPD \| DISEASES 4502 \| MT2A \| DISEASES 3659 \| IRF1 \| DISEASES 30833 \| NT5C \| DISEASES 8189 \| SYMPK \| DISEASES 1236 \| CCR7 \| DISEASES 8139 \| GAN \| DISEASES 968 \| CD68 \| DISEASES 6351 \| CCL4 \| DISEASES 348 \| APOE \| DISEASES 55902 \| ACSS2 \| DISEASES 22 \| ABCB7 \| DISEASES 301 \| ANXA1 \| DISEASES 3569 \| IL6 \| DISEASES 6366 \| CCL21 \| DISEASES 8870 \| IER3 \| DISEASES 7097 \| TLR2 \| DISEASES 4069 \| LYZ \| DISEASES 1459 \| CSNK2A2 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 2208 \| FCER2 \| DISEASES 941 \| CD80 \| DISEASES 3383 \| ICAM1 \| DISEASES 10058 \| ABCB6 \| DISEASES 6523 \| SLC5A1 \| DISEASES 7112 \| TMPO \| DISEASES 6647 \| SOD1 \| DISEASES 5226 \| PGD \| DISEASES 90226 \| UCN2 \| DISEASES 3001 \| GZMA \| DISEASES 3578 \| IL9 \| DISEASES 9046 \| DOK2 \| DISEASES 9453 \| GGPS1 \| DISEASES 170692 \| ADAMTS18 \| DISEASES 1360 \| CPB1 \| DISEASES 2220 \| FCN2 \| DISEASES 729230 \| CCR2 \| DISEASES 1234 \| CCR5 \| DISEASES 6352 \| CCL5 \| DISEASES 6360 \| CCL16 \| DISEASES 1973 \| EIF4A1 \| DISEASES 2215 \| FCGR3B \| DISEASES 3973 \| LHCGR \| DISEASES 2921 \| CXCL3 \| DISEASES 308 \| ANXA5 \| DISEASES 1437 \| CSF2 \| DISEASES 22853 \| LMTK2 \| DISEASES 3429 \| IFI27 \| DISEASES 79158 \| GNPTAB \| DISEASES 92292 \| GLYATL1 \| DISEASES 3308 \| HSPA4 \| DISEASES 1493 \| CTLA4 \| DISEASES 3596 \| IL13 \| DISEASES 3627 \| CXCL10 \| DISEASES 3575 \| IL7R \| DISEASES 6373 \| CXCL11 \| DISEASES 358 \| AQP1 \| DISEASES 54472 \| TOLLIP \| DISEASES 30835 \| CD209 \| DISEASES 10332 \| CLEC4M \| DISEASES 4351 \| MPI \| DISEASES 1068 \| CETN1 \| DISEASES 170825 \| GSX2 \| DISEASES 2193 \| FARSA \| DISEASES 6863 \| TAC1 \| DISEASES 9625 \| AATK \| DISEASES 9033 \| PKD2L1 \| DISEASES 55486 \| PARL \| DISEASES 1974 \| EIF4A2 \| DISEASES 4843 \| NOS2 \| DISEASES 29933 \| GPR132 \| DISEASES 10871 \| CD300C \| DISEASES 5271 \| SERPINB8 \| DISEASES 942 \| CD86 \| DISEASES 8338 \| HIST2H2AC \| DISEASES 430 \| ASCL2 \| DISEASES 3916 \| LAMP1 \| DISEASES 2009 \| EML1 \| DISEASES 114548 \| NLRP3 \| DISEASES 200162 \| SPAG17 \| DISEASES 3455 \| IFNAR2 \| DISEASES 3605 \| IL17A \| DISEASES 3005 \| H1F0 \| DISEASES 3638 \| INSIG1 \| DISEASES 1798 \| DPAGT1 \| DISEASES 8794 \| TNFRSF10C \| DISEASES 79930 \| DOK3 \| DISEASES 85569 \| GALP \| DISEASES 23224 \| SYNE2 \| DISEASES 871 \| SERPINH1 \| DISEASES 51592 \| TRIM33 \| DISEASES 11005 \| SPINK5 \| DISEASES 5792 \| PTPRF \| DISEASES 10072 \| DPP3 \| DISEASES 9361 \| LONP1 \| DISEASES 54106 \| TLR9 \| DISEASES 4519 \| MT-CYB \| DISEASES 4283 \| CXCL9 \| DISEASES 7096 \| TLR1 \| DISEASES 7432 \| VIP \| DISEASES 356 \| FASLG \| DISEASES 2214 \| FCGR3A \| DISEASES 51744 \| CD244 \| DISEASES 383 \| ARG1 \| DISEASES 910 \| CD1B \| DISEASES 6280 \| S100A9 \| DISEASES 7062 \| TCHH \| DISEASES 284486 \| THEM5 \| DISEASES 8349 \| HIST2H2BE \| DISEASES 8337 \| HIST2H2AA3 \| DISEASES 29944 \| PNMA3 \| DISEASES 959 \| CD40LG \| DISEASES 10561 \| IFI44 \| DISEASES 10964 \| IFI44L \| DISEASES 27022 \| FOXD3 \| DISEASES 377841 \| ENTPD8 \| DISEASES 3434 \| IFIT1 \| DISEASES 958 \| CD40 \| DISEASES 22845 \| DOLK \| DISEASES 64121 \| RRAGC \| DISEASES 2833 \| CXCR3 \| DISEASES 7099 \| TLR4 \| DISEASES 164091 \| PAQR7 \| DISEASES 50943 \| FOXP3 \| DISEASES 5293 \| PIK3CD \| DISEASES 9563 \| H6PD \| DISEASES 6354 \| CCL7 \| DISEASES 9308 \| CD83 \| DISEASES 7293 \| TNFRSF4 \| DISEASES 7498 \| XDH \| DISEASES 3456 \| IFNB1 \| DISEASES 51284 \| TLR7 \| DISEASES 5272 \| SERPINB9 \| DISEASES 10333 \| TLR6 \| DISEASES 23041 \| MON2 \| DISEASES 6355 \| CCL8 \| DISEASES 9255 \| AIMP1 \| DISEASES 2875 \| GPT \| DISEASES 594857 \| NPS \| DISEASES 81502 \| HM13 \| DISEASES 50489 \| CD207 \| DISEASES 6147 \| RPL23A \| DISEASES 7124 \| TNF \| DISEASES 2313 \| FLI1 \| DISEASES 4049 \| LTA \| DISEASES 2821 \| GPI \| DISEASES 4050 \| LTB \| DISEASES 89782 \| LMLN \| DISEASES 3586 \| IL10 \| DISEASES 2920 \| CXCL2 \| DISEASES 6224 \| RPS20 \| DISEASES 9973 \| CCS \| DISEASES 4190 \| MDH1 \| DISEASES 8725 \| URI1 \| DISEASES 8972 \| MGAM \| DISEASES 3851 \| KRT4 \| DISEASES 4065 \| LY75 \| DISEASES 6029 \| RN7SL1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	632
Disease	cutaneous leishmaniasis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:10) HP:0100279 \| Ulcerative colitis \| 1 HP:0002583 \| Colitis \| 1 HP:0002910 \| Elevated transaminases \| 1 HP:0011355 \| Localized skin lesion \| 1 HP:0000964 \| Eczema \| 1 HP:0002202 \| Pleural effusion \| 1 HP:0001075 \| Thin, atrophic scars \| 1 HP:0000124 \| Renal tubular defect \| 1 HP:0001818 \| Paronychia \| 1 HP:0002721 \| Immunodeficiency \| 1

Disease ID	632
Disease	cutaneous leishmaniasis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0037284 \| skin lesions \| 6 C0009450 \| infection \| 3

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs2276631	25603101	6556	SLC11A1	umls:C0023283	BeFree	Alleles rs2276631-C (P = 0.02; OR [95%CI] = 2.11 [1.16-3.86]) and rs2279015-G (P = 0.005; OR [95%CI] = 2.42 [1.33-4.41]) of SLC11A1, were associated with susceptibility to VL, whereas genotypes rs2276631 C/C (P = 0.003; OR [95%CI] = 2.65 [1.41-5.00]) and rs2279015 G/G (P = 0.018; OR [95%CI] = 2.05 [1.15-3.64]) were significantly increased in CL and VL patients, respectively.	0.003181358	2015	SLC11A1	2	218384290	C	T
rs2279015	25603101	6556	SLC11A1	umls:C0023283	BeFree	Alleles rs2276631-C (P = 0.02; OR [95%CI] = 2.11 [1.16-3.86]) and rs2279015-G (P = 0.005; OR [95%CI] = 2.42 [1.33-4.41]) of SLC11A1, were associated with susceptibility to VL, whereas genotypes rs2276631 C/C (P = 0.003; OR [95%CI] = 2.65 [1.41-5.00]) and rs2279015 G/G (P = 0.018; OR [95%CI] = 2.05 [1.15-3.64]) were significantly increased in CL and VL patients, respectively.	0.003181358	2015	SLC11A1	2	218394547	G	A
rs5743708	20388552	7097	TLR2	umls:C0023283	BeFree	Lack of association of Toll-Like Receptor 2 Arg753Gln with cutaneous leishmaniasis.	0.001085767	2010	TLR2	4	153705165	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:5)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0023283	allopurinol	D000493	315-30-0	leishmaniasis, cutaneous	MESH:D016773	therapeutic	12207774
C0023283	indomethacin	D007213	53-86-1	leishmaniasis, cutaneous	MESH:D016773	therapeutic	10320625
C0023283	liposomal amphotericin b	C068538	-	leishmaniasis, cutaneous	MESH:D016773	therapeutic	14988693
C0023283	miltefosine	C039128	-	leishmaniasis, cutaneous	MESH:D016773	therapeutic	18256415
C0023283	omeprazole	D009853	73590-58-6	leishmaniasis, cutaneous	MESH:D016773	therapeutic	19248655

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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