PedAM

Pediatric Disease Annotations & Medicines


	cryptococcal meningitis

Disease ID	1263
Disease	cryptococcal meningitis
Definition	Meningeal inflammation produced by CRYPTOCOCCUS NEOFORMANS, an encapsulated yeast that tends to infect individuals with ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunocompromised states. The organism enters the body through the respiratory tract, but symptomatic infections are usually limited to the lungs and nervous system. The organism may also produce parenchymal brain lesions (torulomas). Clinically, the course is subacute and may feature HEADACHE; NAUSEA; PHOTOPHOBIA; focal neurologic deficits; SEIZURES; cranial neuropathies; and HYDROCEPHALUS. (From Adams et al., Principles of Neurology, 6th ed, pp721-2)
Synonym	crypto meningitis cryptococcal meningitides cryptococcal meningitis (disorder) meningitides, cryptococcal meningitis cryptococcal meningitis due to cryptococcus meningitis torula meningitis, cryptococcal meningitis, cryptococcal [disease/finding]
DOID	DOID:12052
UMLS	C0085436
MeSH	D016919
SNOMED-CT	SNOMEDCT_US_2016_09_01:14232007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:33) C0151740 \| intracranial hypertension \| 4 C0020538 \| hypertension \| 3 C0019158 \| hepatitis \| 3 C0010414 \| cryptococcosis \| 3 C0151740 \| raised intracranial pressure \| 2 C0019196 \| hepatitis c \| 2 C0029132 \| optic neuropathy \| 2 C0442874 \| neuropathy \| 2 C0270612 \| leukoencephalopathy \| 1 C0011847 \| diabetes \| 1 C0023448 \| lymphocytic leukemia \| 1 C0497327 \| dementia \| 1 C0002878 \| hemolytic anemia \| 1 C0025289 \| meningitis \| 1 C0001175 \| acquired immune deficiency syndrome (aids) \| 1 C0042769 \| virus infection \| 1 C0041296 \| tuberculosis \| 1 C0276688 \| pulmonary cryptococcosis \| 1 C0026896 \| myasthenia gravis \| 1 C0030353 \| papilledema \| 1 C0001175 \| acquired immune deficiency \| 1 C0001175 \| acquired immune deficiency syndrome \| 1 C0011570 \| depression \| 1 C0002880 \| autoimmune hemolytic anemia \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0019163 \| hepatitis b \| 1 C0151740 \| elevated intracranial pressure \| 1 C0456909 \| vision loss \| 1 C0151740 \| increased intracranial pressure \| 1 C0020255 \| hydrocephalus \| 1 C0010414 \| cryptococcus neoformans \| 1 C0456909 \| blindness \| 1 C0001125 \| lactic acidosis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:85) 920 \| CD4 \| DISEASES 608 \| TNFRSF17 \| DISEASES 123263 \| MTFMT \| DISEASES 2765 \| GML \| DISEASES 973 \| CD79A \| DISEASES 59 \| ACTA2 \| DISEASES 6348 \| CCL3 \| DISEASES 1440 \| CSF3 \| DISEASES 6347 \| CCL2 \| DISEASES 3558 \| IL2 \| DISEASES 1410 \| CRYAB \| DISEASES 3458 \| IFNG \| DISEASES 55856 \| ACOT13 \| DISEASES 3565 \| IL4 \| DISEASES 5534 \| PPP3R1 \| DISEASES 4360 \| MRC1 \| DISEASES 417 \| ART1 \| DISEASES 5375 \| PMP2 \| DISEASES 3569 \| IL6 \| DISEASES 4836 \| NMT1 \| DISEASES 23495 \| TNFRSF13B \| DISEASES 4591 \| TRIM37 \| DISEASES 23523 \| CABIN1 \| DISEASES 28960 \| DCPS \| DISEASES 80725 \| SRCIN1 \| DISEASES 259 \| AMBP \| DISEASES 1390 \| CREM \| DISEASES 5371 \| PML \| DISEASES 409 \| ARRB2 \| DISEASES 2212 \| FCGR2A \| DISEASES 805 \| CALM2 \| DISEASES 2180 \| ACSL1 \| DISEASES 115650 \| TNFRSF13C \| DISEASES 808 \| CALM3 \| DISEASES 6777 \| STAT5B \| DISEASES 2215 \| FCGR3B \| DISEASES 213 \| ALB \| DISEASES 9607 \| CARTPT \| DISEASES 1437 \| CSF2 \| DISEASES 260434 \| PYDC1 \| DISEASES 3627 \| CXCL10 \| DISEASES 7532 \| YWHAG \| DISEASES 4968 \| OGG1 \| DISEASES 344561 \| GPR148 \| DISEASES 1072 \| CFL1 \| DISEASES 653499 \| LGALS7B \| DISEASES 1776 \| DNASE1L3 \| DISEASES 2318 \| FLNC \| DISEASES 3984 \| LIMK1 \| DISEASES 9094 \| UNC119 \| DISEASES 112744 \| IL17F \| DISEASES 51477 \| ISYNA1 \| DISEASES 6776 \| STAT5A \| DISEASES 3605 \| IL17A \| DISEASES 7549 \| ZNF2 \| DISEASES 801 \| CALM1 \| DISEASES 2213 \| FCGR2B \| DISEASES 7096 \| TLR1 \| DISEASES 3664 \| IRF6 \| DISEASES 2214 \| FCGR3A \| DISEASES 1847 \| DUSP5 \| DISEASES 959 \| CD40LG \| DISEASES 642489 \| FKBP1C \| DISEASES 2833 \| CXCR3 \| DISEASES 4153 \| MBL2 \| DISEASES 10919 \| EHMT2 \| DISEASES 10673 \| TNFSF13B \| DISEASES 160897 \| GPR180 \| DISEASES 2550 \| GABBR1 \| DISEASES 6354 \| CCL7 \| DISEASES 3963 \| LGALS7 \| DISEASES 7293 \| TNFRSF4 \| DISEASES 1993 \| ELAVL2 \| DISEASES 551 \| AVP \| DISEASES 2280 \| FKBP1A \| DISEASES 93978 \| CLEC6A \| DISEASES 8812 \| CCNK \| DISEASES 7520 \| XRCC5 \| DISEASES 196410 \| METTL7B \| DISEASES 57703 \| CWC22 \| DISEASES 7124 \| TNF \| DISEASES 3586 \| IL10 \| DISEASES 5478 \| PPIA \| DISEASES 5158 \| PDE6B \| DISEASES 3684 \| ITGAM \| DISEASES
Locus	(Waiting for update.)

Disease ID	1263
Disease	cryptococcal meningitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:30) HP:0002721 \| Immunodeficiency \| 5 HP:0002516 \| Intracranial pressure elevation \| 4 HP:0000822 \| Hypertension \| 3 HP:0012115 \| Liver inflammation \| 3 HP:0002315 \| Headaches \| 2 HP:0001945 \| Fever \| 2 HP:0001138 \| Damaged optic nerve \| 2 HP:0000572 \| Visual loss \| 2 HP:0100754 \| Mania \| 2 HP:0012229 \| Cerebrospinal fluid pleocytosis \| 1 HP:0002039 \| Anorexia \| 1 HP:0011450 \| CNS infection \| 1 HP:0002902 \| Hyponatremia \| 1 HP:0007824 \| Total ophthalmoplegia \| 1 HP:0001085 \| Papilledema \| 1 HP:0000726 \| Dementia \| 1 HP:0001890 \| Autoimmune hemolytic anemia \| 1 HP:0001941 \| acidemia \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0000127 \| Salt wasting \| 1 HP:0003128 \| Lactic acidosis \| 1 HP:0004326 \| Cachexia \| 1 HP:0000238 \| Nonsyndromal hydrocephalus \| 1 HP:0000716 \| Depression \| 1 HP:0000618 \| Blindness \| 1 HP:0001287 \| Meningitis \| 1 HP:0002138 \| Subarachnoid hemorrhage \| 1 HP:0001878 \| Haemolytic anaemia \| 1 HP:0003473 \| Fatigable weakness \| 1

Disease ID	1263
Disease	cryptococcal meningitis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:12) C0009450 \| infection \| 3 C0029132 \| optic neuropathy \| 2 C0151740 \| elevated intracranial pressure \| 1 C0276688 \| pulmonary cryptococcosis \| 1 C2062955 \| cryptococcoma \| 1 C0020625 \| hyponatremia \| 1 C0029118 \| opportunistic infections \| 1 C1839611 \| n syndrome \| 1 C0030353 \| papilledema \| 1 C0020255 \| hydrocephalus \| 1 C0456909 \| blindness \| 1 C0742911 \| cryptococcemia \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1050501	22879986	2213	FCGR2B	umls:C0085436	BeFree	We found for the first time associations between cryptococcal meningitis and FCGR2B 232I/T genotypes, which suggested that FcγRIIB might play an important role in the central nervous system infection by Cryptococcus in HIV-uninfected individuals.	0.000271442	2012	FCGR2B	1	161674008	T	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:3)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0085436	fluconazole	D015725	86386-73-4	meningitis, cryptococcal	MESH:D016919	therapeutic	16983622
C0085436	liposomal amphotericin b	C068538	-	meningitis, cryptococcal	MESH:D016919	therapeutic	15507243
C0085436	temozolomide	C047246	85622-93-1	meningitis, cryptococcal	MESH:D016919	marker/mechanism	18398572

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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