PedAM
Pediatric Disease Annotations & Medicines
| coronary artery vasospasm | ||||
| Disease ID | 838 |
|---|---|
| Disease | coronary artery vasospasm |
| Definition | Spasm of the large- or medium-sized coronary arteries. |
| Synonym | arteriospasm coronary artery coronary spasm artery coronary spasms artery vasospasm, coronary artery vasospasms, coronary coronaries spasm coronary artery spasm coronary artery spasm (disorder) coronary artery vasospasms coronary spasm coronary spasms coronary vasospasm coronary vasospasm [disease/finding] coronary vasospasms spasm coronary artery vasospasm coronary vasospasm, coronary vasospasm, coronary artery vasospasms, coronary vasospasms, coronary artery |
| DOID | |
| UMLS | C0010073 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:4) C0040147 | thyroiditis | 1 C0155626 | acute myocardial infarction | 1 C0027051 | myocardial infarct | 1 C0027051 | myocardial infarction | 1 |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:3) |
| Inferring Gene | Entrez_id | Symbol | Resource(Total Genes:7) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:50) 9352 | TXNL1 | DISEASES 6445 | SGCG | DISEASES 3764 | KCNJ8 | DISEASES 1401 | CRP | DISEASES 377 | ARF3 | DISEASES 27429 | HTRA2 | DISEASES 10060 | ABCC9 | DISEASES 4659 | PPP1R12A | DISEASES 8989 | TRPA1 | DISEASES 10874 | NMU | DISEASES 3827 | KNG1 | DISEASES 5286 | PIK3C2A | DISEASES 3779 | KCNMB1 | DISEASES 7941 | PLA2G7 | DISEASES 10398 | MYL9 | DISEASES 84539 | MCHR2 | DISEASES 7079 | TIMP4 | DISEASES 5739 | PTGIR | DISEASES 5473 | PPBP | DISEASES 4846 | NOS3 | DISEASES 171389 | NLRP6 | DISEASES 3352 | HTR1D | DISEASES 55588 | MED29 | DISEASES 9475 | ROCK2 | DISEASES 5912 | RAP2B | DISEASES 6863 | TAC1 | DISEASES 3996 | LLGL1 | DISEASES 3363 | HTR7 | DISEASES 7137 | TNNI3 | DISEASES 10488 | CREB3 | DISEASES 5962 | RDX | DISEASES 7139 | TNNT2 | DISEASES 336 | APOA2 | DISEASES 3351 | HTR1B | DISEASES 1491 | CTH | DISEASES 5730 | PTGDS | DISEASES 80312 | TET1 | DISEASES 9754 | STARD8 | DISEASES 5394 | EXOSC10 | DISEASES 1906 | EDN1 | DISEASES 5256 | PHKA2 | DISEASES 6833 | ABCC8 | DISEASES 654364 | NME1-NME2 | DISEASES 6093 | ROCK1 | DISEASES 387 | RHOA | DISEASES 11155 | LDB3 | DISEASES 8972 | MGAM | DISEASES 5228 | PGF | DISEASES 102723508 | KANTR | DISEASES 94161 | SNORD46 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 838 |
|---|---|
| Disease | coronary artery vasospasm |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:4) HP:0030149 | Cardiovascular shock | 1 HP:0001658 | Myocardial infarction | 1 HP:0001662 | Bradycardia | 1 HP:0100646 | Thyroiditis | 1 |
| Disease ID | 838 |
|---|---|
| Disease | coronary artery vasospasm |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:1) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:17) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs10498345 | 18075462 | 161198 | CLEC14A | umls:C0010073 | GAD | [SNP rs10498345 was strongly associated with coronary spasm in Japanese women utilizing genome-wide SNP analysis.] | 0.002367032 | 2007 | NA | 14 | 38551301 | T | A |
| rs11544238 | 19911011 | 64333 | ARHGAP9 | umls:C0010073 | BeFree | The Ala370Ser polymorphism in the ARHGAP9 gene is associated with coronary artery spasm. | 0.120271442 | 2010 | ARHGAP9 | 12 | 57476372 | A | G,C |
| rs1799983 | 12727149 | 4846 | NOS3 | umls:C0010073 | BeFree | The TT genotype of the single nucleotide polymorphism 894 G/T, located in exon 7 of the eNOS gene, was found to be associated with coronary spasm, coronary artery disease (CAD) and myocardial infarction (MI). | 0.138435641 | 2003 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 11745998 | 4846 | NOS3 | umls:C0010073 | BeFree | Recently, a Glu298Asp variant of the endothelial nitric oxide synthase gene (NOS3) was identified as being associated with coronary spasm and myocardial infarction, whereas it has been reported that endothelial nitric oxide synthase plays a role in HP. | 0.138435641 | 2001 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 12826928 | 4846 | NOS3 | umls:C0010073 | BeFree | The Glu298Asp polymorphism in the endothelial nitric oxide synthase gene is strongly associated with coronary spasm. | 0.138435641 | 2003 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 9737779 | 4846 | NOS3 | umls:C0010073 | BeFree | A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese. | 0.138435641 | 1998 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 9626827 | 4846 | NOS3 | umls:C0010073 | BeFree | Recently, we reported that a missense Glu298Asp variant in exon 7 of the eNOS gene is a possible genetic factor involved in the pathogenesis of coronary spasm. | 0.138435641 | 1998 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 10979242 | 4846 | NOS3 | umls:C0010073 | BeFree | Genetic risk factors for coronary artery spasm: significance of endothelial nitric oxide synthase gene T-786-->C and missense Glu298Asp variants. | 0.138435641 | 2000 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 21287574 | 4846 | NOS3 | umls:C0010073 | BeFree | Three polymorphisms, Paraoxonase 1 (PON1) Q192R (C/G), endothelial nitric oxide synthase (eNOS) E298D (G/T) and eNOS T-786C have been suggested to be potentially associated with coronary artery spasm in Japanese patients. | 0.138435641 | 2011 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 12243851 | 4846 | NOS3 | umls:C0010073 | BeFree | Recent reports have suggested that the Glu298Asp polymorphism in exon 7 of the endothelial nitric oxide synthase gene is associated with coronary spasm and acute myocardial infarction. | 0.138435641 | 2002 | NOS3 | 7 | 150999023 | T | G |
| rs41322052 | 17622934 | 4846 | NOS3 | umls:C0010073 | BeFree | The endothelial nitric oxide synthase gene -786T/C polymorphism is a predictive factor for reattacks of coronary spasm. | 0.138435641 | 2007 | NOS3 | 7 | 150993018 | C | T |
| rs41322052 | 17029342 | 4846 | NOS3 | umls:C0010073 | BeFree | In recent studies from the cardiology literature, researchers have suggested that a genetic predisposition to coronary vasospasm might develop as the result of a T-786C single nucleotide polymorphism (SNP) in the eNOS gene. | 0.138435641 | 2006 | NOS3 | 7 | 150993018 | C | T |
| rs41322052 | 21287574 | 4846 | NOS3 | umls:C0010073 | BeFree | Three polymorphisms, Paraoxonase 1 (PON1) Q192R (C/G), endothelial nitric oxide synthase (eNOS) E298D (G/T) and eNOS T-786C have been suggested to be potentially associated with coronary artery spasm in Japanese patients. | 0.138435641 | 2011 | NOS3 | 7 | 150993018 | C | T |
| rs41322052 | 20211321 | 4846 | NOS3 | umls:C0010073 | BeFree | Because the endothelial nitric oxide synthase (eNOS) T-786C polymorphism is associated with reduced nitric oxide production and coronary artery spasm in Japanese patients, we speculated that it might be reversibly associated with Prinzmetal's variant angina in white Americans. | 0.138435641 | 2010 | NOS3 | 7 | 150993018 | C | T |
| rs41322052 | 18075462 | 4846 | NOS3 | umls:C0010073 | BeFree | We previously found a -786T/C polymorphism in the 5'-flanking region of the endothelial nitric oxide synthase (eNOS) gene and reported that this polymorphism is associated with coronary spasm. | 0.138435641 | 2007 | NOS3 | 7 | 150993018 | C | T |
| rs662 | 21287574 | 4846 | NOS3 | umls:C0010073 | BeFree | Three polymorphisms, Paraoxonase 1 (PON1) Q192R (C/G), endothelial nitric oxide synthase (eNOS) E298D (G/T) and eNOS T-786C have been suggested to be potentially associated with coronary artery spasm in Japanese patients. | 0.138435641 | 2011 | PON1 | 7 | 95308134 | T | C |
| rs662 | 21287574 | 5444 | PON1 | umls:C0010073 | BeFree | First survey of the three gene polymorphisms (PON1 Q192R, eNOS E298D and eNOS C-786T) potentially associated with coronary artery spasm in African populations and comparison with worldwide data. | 0.122909916 | 2011 | PON1 | 7 | 95308134 | T | C |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
|---|
| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
|---|
| (Waiting for update.) |
Chemical(Total Drugs:28) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0010073 | amphetamine | D000661 | 300-62-9 | coronary vasospasm | MESH:D003329 | marker/mechanism | 12587947 | ||
| C0010073 | atenolol | D001262 | 29122-68-7 | coronary vasospasm | MESH:D003329 | marker/mechanism | 17692760 | ||
| C0010073 | atropine | D001285 | 51-55-8 | coronary vasospasm | MESH:D003329 | marker/mechanism | 17262096 | ||
| C0010073 | betamethasone | D001623 | 378-44-9 | coronary vasospasm | MESH:D003329 | marker/mechanism | 8629796 | ||
| C0010073 | caffeine | D002110 | 1958/8/2 | coronary vasospasm | MESH:D003329 | marker/mechanism | 19120009 | ||
| C0010073 | capsaicin | D002211 | 404-86-4 | coronary vasospasm | MESH:D003329 | marker/mechanism | 20098047 | ||
| C0010073 | cimetidine | D002927 | 51481-61-9 | coronary vasospasm | MESH:D003329 | marker/mechanism | 3594301 | ||
| C0010073 | citalopram | D015283 | 59729-33-8 | coronary vasospasm | MESH:D003329 | marker/mechanism | 20159412 | ||
| C0010073 | cyclophosphamide | D003520 | 50-18-0 | coronary vasospasm | MESH:D003329 | marker/mechanism | 12439602 | ||
| C0010073 | diclofenac | D004008 | 15307-86-5 | coronary vasospasm | MESH:D003329 | marker/mechanism | 15803264 | ||
| C0010073 | digoxin | D004077 | 20830-75-5 | coronary vasospasm | MESH:D003329 | marker/mechanism | 7810184 | ||
| C0010073 | dihydroergotamine | D004087 | 511-12-6 | coronary vasospasm | MESH:D003329 | marker/mechanism | 8312801 | ||
| C0010073 | fluorouracil | D005472 | 51-21-8 | coronary vasospasm | MESH:D003329 | marker/mechanism | 11321998 | ||
| C0010073 | leucovorin | D002955 | 1958/5/9 | coronary vasospasm | MESH:D003329 | marker/mechanism | 15701780 | ||
| C0010073 | indomethacin | D007213 | 53-86-1 | coronary vasospasm | MESH:D003329 | marker/mechanism | 9220183 | ||
| C0010073 | labetalol | D007741 | 36894-69-6 | coronary vasospasm | MESH:D003329 | marker/mechanism | 2060359 | ||
| C0010073 | methylphenidate | D008774 | 113-45-1 | coronary vasospasm | MESH:D003329 | marker/mechanism | 18024065 | ||
| C0010073 | nicotine | D009538 | - | coronary vasospasm | MESH:D003329 | marker/mechanism | 19559087 | ||
| C0010073 | paclitaxel | D017239 | - | coronary vasospasm | MESH:D003329 | marker/mechanism | 12677287 | ||
| C0010073 | phenylephrine | D010656 | 59-42-7 | coronary vasospasm | MESH:D003329 | marker/mechanism | 6115627 | ||
| C0010073 | propranolol | D011433 | 525-66-6 | coronary vasospasm | MESH:D003329 | marker/mechanism | 6133636 | ||
| C0010073 | sirolimus | D020123 | 53123-88-9 | coronary vasospasm | MESH:D003329 | marker/mechanism | 16682323 | ||
| C0010073 | sorafenib | C471405 | - | coronary vasospasm | MESH:D003329 | marker/mechanism | 19944333 | ||
| C0010073 | sotalol | D013015 | 3930-20-9 | coronary vasospasm | MESH:D003329 | marker/mechanism | 15609701 | ||
| C0010073 | sotalol | D013015 | 3930-20-9 | coronary vasospasm | MESH:D003329 | therapeutic | 9659206 | ||
| C0010073 | tacrolimus | D016559 | 109581-93-3 | coronary vasospasm | MESH:D003329 | marker/mechanism | 12975596 | ||
| C0010073 | trandolapril | C052035 | - | coronary vasospasm | MESH:D003329 | therapeutic | 8909991 | ||
| C0010073 | zolmitriptan | C089750 | - | coronary vasospasm | MESH:D003329 | marker/mechanism | 20159412 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
|---|---|
| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
|---|---|
| (Waiting for update.) | |