PedAM

Pediatric Disease Annotations & Medicines


	coronary aneurysm

Disease ID	830
Disease	coronary aneurysm
Definition	Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.
Synonym	aneurysm arteries coronary aneurysm artery coronary aneurysm coronary artery aneurysm coronary vessel aneurysm of coronary vessels aneurysm of coronary vessels (disorder) aneurysm, coronary aneurysmal lesion of coronary artery aneurysmal lesion of coronary artery (finding) aneurysms, coronary arteriovenous aneurysm of coronary vessels coronary aneurysm [disease/finding] coronary aneurysms coronary artery aneurysm coronary artery aneurysms
DOID	DOID:3362
ICD10	ICD10CM:I25.41
UMLS	C0010051
MeSH	D003323
SNOMED-CT	SNOMEDCT_US_2016_09_01:50570003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:45) C0026691 \| kawasaki disease \| 38 C0027051 \| myocardial infarct \| 14 C0027051 \| myocardial infarction \| 14 C0155626 \| acute myocardial infarction \| 8 C0040053 \| thrombosis \| 8 C0040053 \| thrombus \| 5 C0004943 \| behcet's disease \| 4 C0042384 \| vasculitis \| 3 C0018799 \| heart disease \| 3 C0242231 \| coronary artery stenosis \| 2 C0003873 \| rheumatoid arthritis \| 2 C0026691 \| kawasaki syndrome \| 2 C0007177 \| cardiac tamponade \| 2 C0003486 \| aortic aneurysm \| 2 C0008728 \| churg-strauss syndrome \| 2 C0039263 \| takayasu arteritis \| 2 C0010068 \| coronary artery disease \| 1 C0030421 \| paraganglioma \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0026269 \| mitral stenosis \| 1 C0031039 \| pericardial effusions \| 1 C0027051 \| myocardial infarction (mi) \| 1 C0011880 \| diabetic ketoacidosis \| 1 C0151744 \| ischaemic heart disease \| 1 C0022116 \| ischaemia \| 1 C0043092 \| wegener's granulomatosis \| 1 C0034359 \| pyuria \| 1 C0029434 \| osteogenesis imperfecta \| 1 C0149642 \| cervical lymphadenitis \| 1 C0003504 \| aortic insufficiency \| 1 C0031036 \| polyarteritis nodosa \| 1 C0022116 \| ischemia \| 1 C0206141 \| hypereosinophilic syndrome \| 1 C0151744 \| myocardial ischemia \| 1 C0162871 \| abdominal aortic aneurysm \| 1 C0242231 \| coronary stenosis \| 1 C0003486 \| aortic aneurysms \| 1 C0409974 \| lupus erythematosus \| 1 C0087086 \| thrombi \| 1 C0027051 \| myocardial infarctions \| 1 C0031039 \| pericardial effusion \| 1 C0024205 \| lymphadenitis \| 1 C0026691 \| kawasaki's disease \| 1 C0014118 \| endocarditis \| 1 C0010051 \| coronary aneurysms \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) ITPKC \| 80271 \| CTD_human GJA1 \| 2697 \| CTD_human MICA \| 100507436 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:35) 7132 \| TNFRSF1A \| DISEASES 3002 \| GZMB \| DISEASES 56729 \| RETN \| DISEASES 6347 \| CCL2 \| DISEASES 7035 \| TFPI \| DISEASES 7128 \| TNFAIP3 \| DISEASES 5184 \| PEPD \| DISEASES 1446 \| CSN1S1 \| DISEASES 6351 \| CCL4 \| DISEASES 5894 \| RAF1 \| DISEASES 10343 \| PKDREJ \| DISEASES 1401 \| CRP \| DISEASES 3569 \| IL6 \| DISEASES 5310 \| PKD1 \| DISEASES 7379 \| UPK2 \| DISEASES 7297 \| TYK2 \| DISEASES 213 \| ALB \| DISEASES 4314 \| MMP3 \| DISEASES 171558 \| PTCRA \| DISEASES 4330 \| MN1 \| DISEASES 767 \| CA8 \| DISEASES 2152 \| F3 \| DISEASES 3455 \| IFNAR2 \| DISEASES 959 \| CD40LG \| DISEASES 4318 \| MMP9 \| DISEASES 80312 \| TET1 \| DISEASES 100507436 \| MICA \| DISEASES 9560 \| CCL4L2 \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 11155 \| LDB3 \| DISEASES 388372 \| CCL4L1 \| DISEASES 79827 \| CLMP \| DISEASES 81704 \| DOCK8 \| DISEASES 102723508 \| KANTR \| DISEASES
Locus	(Waiting for update.)

Disease ID	830
Disease	coronary aneurysm
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:29) HP:0001658 \| Myocardial infarction \| 12 HP:0004947 \| Arteriovenous fistula \| 5 HP:0011641 \| Coronary artery fistula \| 4 HP:0002633 \| Vasculitis \| 3 HP:0002617 \| Aneurysmal dilatation \| 2 HP:0004942 \| Aortic aneurysm \| 2 HP:0005145 \| Narrowing of coronary artery \| 2 HP:0100749 \| Thoracic pain \| 2 HP:0001370 \| Rheumatoid arthritis \| 2 HP:0004953 \| Abdominal aortic aneurysm \| 1 HP:0001647 \| Bicuspid aortic valve \| 1 HP:0001718 \| Mitral stenosis \| 1 HP:0001649 \| Tachycardia \| 1 HP:0012531 \| Pain \| 1 HP:0002668 \| Paragangliomas \| 1 HP:0001643 \| Persistent ductus arteriosus \| 1 HP:0011672 \| Cardiac myxoma \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0001659 \| Aortic insufficiency \| 1 HP:0002631 \| Ascending aortic aneurysm \| 1 HP:0100584 \| Endocarditis \| 1 HP:0001953 \| Diabetic ketosis \| 1 HP:0006702 \| Spontaneous coronary artery dissection \| 1 HP:0001698 \| Pericardial effusions \| 1 HP:0001677 \| Coronary artery disease \| 1 HP:0004935 \| Pulmonary atresia \| 1 HP:0012085 \| High urine neutrophil count \| 1 HP:0001645 \| Sudden cardiac death \| 1 HP:0012089 \| Arteritis \| 1

Disease ID	830
Disease	coronary aneurysm
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:4) C0026691 \| kawasaki disease \| 37 C0040053 \| thrombosis \| 2 C0010068 \| coronary artery disease \| 1 C0162871 \| abdominal aortic aneurysm \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1800872	17413867	3586	IL10	umls:C0010051	BeFree	The IL-10 (-627 A/C) promoter polymorphism may be associated with coronary aneurysms and low serum albumin in Korean children with Kawasaki disease.	0.002909916	2007	IL10	1	206773062	T	G
rs1800872	17413867	213	ALB	umls:C0010051	BeFree	The IL-10 (-627 A/C) promoter polymorphism may be associated with coronary aneurysms and low serum albumin in Korean children with Kawasaki disease.	0.000271442	2007	IL10	1	206773062	T	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0010051	amphetamine	D000661	300-62-9	coronary aneurysm	MESH:D003323	marker/mechanism	15316310
C0010051	paclitaxel	D017239	-	coronary aneurysm	MESH:D003323	marker/mechanism	15804801

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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