PedAM

Pediatric Disease Annotations & Medicines


	corneal ulcer

Disease ID	1255
Disease	corneal ulcer
Definition	Loss of epithelial tissue from the surface of the cornea due to progressive erosion and necrosis of the tissue; usually caused by bacterial, fungal, or viral infection.
Synonym	cornea ulcer cornea ulcers cornea--ulcers corneal ulcer (disorder) corneal ulcer (incl herpetic) corneal ulcer (including herpetic) corneal ulcer [disease/finding] corneal ulcer nos corneal ulcer nos (disorder) corneal ulcer, nos corneal ulcer, unspecified corneal ulceration corneal ulcerations corneal ulcers keratitides, ulcerative keratitis, ulcerative ulcer cornea ulcer corneal ulcer, corneal ulcerative keratitides ulcerative keratitis unspecified corneal ulcer unspecified corneal ulcer (disorder)
DOID	DOID:8463
UMLS	C0010043
MeSH	D003320
SNOMED-CT	SNOMEDCT_US_2016_09_01:91514001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:41) C0022568 \| keratitis \| 9 C0235270 \| keratopathy \| 4 C0155111 \| bullous keratopathy \| 3 C0456909 \| blindness \| 2 C0026946 \| fungal infection \| 2 C0014236 \| endophthalmitis \| 2 C0024523 \| malabsorption \| 1 C0004106 \| astigmatism \| 1 C0009763 \| conjunctivitis \| 1 C0442874 \| neuropathy \| 1 C0004623 \| bacterial infection \| 1 C0003873 \| rheumatoid disease \| 1 C0019348 \| herpes simplex \| 1 C0021053 \| immunologic diseases \| 1 C0022573 \| keratoconjunctivitis \| 1 C0036416 \| scleritis \| 1 C0026946 \| fungal infections \| 1 C0031350 \| pharyngitis \| 1 C0020581 \| hyphema \| 1 C0017601 \| glaucoma \| 1 C0155119 \| recurrent corneal erosion \| 1 C0036689 \| streptococcal pharyngitis \| 1 C0152226 \| lagophthalmos \| 1 C0334277 \| metastatic adenocarcinoma \| 1 C0015300 \| proptosis \| 1 C0013238 \| dry eye syndrome \| 1 C0155119 \| recurrent corneal erosions \| 1 C0021053 \| immunologic disease \| 1 C0152455 \| keratomalacia \| 1 C0152177 \| trigeminal neuropathy \| 1 C0162836 \| hidradenitis suppurativa \| 1 C0162429 \| malnutrition \| 1 C0314719 \| dry eye \| 1 C0003873 \| rheumatoid arthritis \| 1 C0036202 \| sarcoidosis \| 1 C0035854 \| rosacea \| 1 C0019348 \| herpes simplex infection \| 1 C0011860 \| type 2 diabetes \| 1 C0085160 \| hidradenitis \| 1 C0042769 \| viral infection \| 1 C0001418 \| adenocarcinoma \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) SERPINF1 \| 5176 \| CTD_human NGF \| 4803 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:71) 27248 \| ERLEC1 \| DISEASES 5753 \| PTK6 \| DISEASES 1472 \| CST4 \| DISEASES 7076 \| TIMP1 \| DISEASES 4313 \| MMP2 \| DISEASES 10804 \| GJB6 \| DISEASES 718 \| C3 \| DISEASES 968 \| CD68 \| DISEASES 1830 \| DSG3 \| DISEASES 1828 \| DSG1 \| DISEASES 90070 \| LACRT \| DISEASES 7077 \| TIMP2 \| DISEASES 10133 \| OPTN \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 3977 \| LIFR \| DISEASES 3383 \| ICAM1 \| DISEASES 4060 \| LUM \| DISEASES 2252 \| FGF7 \| DISEASES 4681 \| NBL1 \| DISEASES 1409 \| CRYAA \| DISEASES 563 \| AZGP1 \| DISEASES 7412 \| VCAM1 \| DISEASES 213 \| ALB \| DISEASES 1230 \| CCR1 \| DISEASES 55764 \| IFT122 \| DISEASES 124872 \| B4GALNT2 \| DISEASES 6356 \| CCL11 \| DISEASES 1448 \| CSN3 \| DISEASES 7399 \| USH2A \| DISEASES 1473 \| CST5 \| DISEASES 5340 \| PLG \| DISEASES 1240 \| CMKLR1 \| DISEASES 4312 \| MMP1 \| DISEASES 2903 \| GRIN2A \| DISEASES 114548 \| NLRP3 \| DISEASES 7100 \| TLR5 \| DISEASES 1861 \| TOR1A \| DISEASES 5265 \| SERPINA1 \| DISEASES 5733 \| PTGER3 \| DISEASES 147409 \| DSG4 \| DISEASES 58484 \| NLRC4 \| DISEASES 3880 \| KRT19 \| DISEASES 58 \| ACTA1 \| DISEASES 1660 \| DHX9 \| DISEASES 1805 \| DPT \| DISEASES 26002 \| MOXD1 \| DISEASES 6283 \| S100A12 \| DISEASES 4803 \| NGF \| DISEASES 2316 \| FLNA \| DISEASES 959 \| CD40LG \| DISEASES 4318 \| MMP9 \| DISEASES 5328 \| PLAU \| DISEASES 26508 \| HEYL \| DISEASES 2934 \| GSN \| DISEASES 3339 \| HSPG2 \| DISEASES 3105 \| HLA-A \| DISEASES 3440 \| IFNA2 \| DISEASES 415 \| ARSE \| DISEASES 2737 \| GLI3 \| DISEASES 55777 \| MBD5 \| DISEASES 3550 \| IK \| DISEASES 7124 \| TNF \| DISEASES 9278 \| ZBTB22 \| DISEASES 81704 \| DOCK8 \| DISEASES 2263 \| FGFR2 \| DISEASES 3551 \| IKBKB \| DISEASES 1232 \| CCR3 \| DISEASES 10198 \| MPHOSPH9 \| DISEASES 10381 \| TUBB3 \| DISEASES 104355217 \| ERICD \| DISEASES
Locus	(Waiting for update.)

Disease ID	1255
Disease	corneal ulcer
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:23) HP:0000491 \| Corneal inflammation \| 9 HP:0100583 \| Corneal perforation \| 3 HP:0000618 \| Blindness \| 2 HP:0004905 \| Vitamin A deficiency \| 2 HP:0000969 \| Dropsy \| 2 HP:0100699 \| Scarring \| 2 HP:0012531 \| Pain \| 1 HP:0000501 \| Glaucoma \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0000520 \| Anterior bulging of the globe of eye \| 1 HP:0012393 \| Allergy \| 1 HP:0030855 \| Anterior staphyloma \| 1 HP:0200020 \| Corneal erosion \| 1 HP:0000559 \| Corneal scarring \| 1 HP:0001059 \| Pterygium \| 1 HP:0002024 \| Intestinal malabsorption \| 1 HP:0000509 \| Conjunctivitis \| 1 HP:0000483 \| Astigmatism \| 1 HP:0040154 \| Hidradenitis suppurativa \| 1 HP:0100532 \| Scleritis \| 1 HP:0001096 \| Keratoconjunctivitis \| 1 HP:0000495 \| Recurrent corneal erosions \| 1 HP:0004395 \| Malnutrition \| 1

Disease ID	1255
Disease	corneal ulcer
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:3) C0026946 \| fungal infection \| 2 C0021311 \| infections \| 1 C0030193 \| pain \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0010043	capsaicin	D002211	404-86-4	corneal ulcer	MESH:D003320	marker/mechanism	19553628

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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