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Pediatric Disease Annotations & Medicines



   contact dermatitis
  

Disease ID 1058
Disease contact dermatitis
Definition
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.
Synonym
cd - contact dermatitis
contact dematitis
contact dermatitides
contact dermatitis (disorder)
contact dermatitis nos
contact dermatitis nos (disorder)
contact dermatitis, nos
contact dermatitis/eczema
contact eczema
contact sensitivities
contact sensitivity
dermatitides, contact
dermatitis - contact
dermatitis contact
dermatitis venenata
dermatitis, contact
dermatitis, contact [disease/finding]
dermatitis, contact nos
dermatitis, venenata nos
eczema - contact
eczema, contact
sensitivities, contact
sensitivity, contact
DOID
UMLS
C0011616
MeSH
SNOMED-CT
Comorbidity
UMLS | Disease | Sentences' Count(Total Sentences:16)
C0013595  |  eczema  |  7
C0011603  |  dermatitis  |  4
C0011615  |  atopic dermatitis  |  4
C0015230  |  rash  |  2
C0033860  |  psoriasis  |  2
C0162820  |  allergic contact dermatitis  |  2
C0004943  |  behcet's disease  |  1
C0007570  |  celiac disease  |  1
C0034103  |  pulpitis  |  1
C0042109  |  urticaria  |  1
C0035854  |  rosacea  |  1
C0024236  |  lymphoedema  |  1
C1527383  |  morphea  |  1
C0011615  |  atopic eczema  |  1
C0011570  |  depression  |  1
C0042384  |  vasculitis  |  1
Curated Gene
Entrez_id | Symbol | Resource(Total Genes:71)
NQO1  |  1728  |  CTD_human
SOD1  |  6647  |  CTD_human
BCL2  |  596  |  CTD_human
CASP8  |  841  |  CTD_human
HMOX1  |  3162  |  CTD_human
G6PD  |  2539  |  CTD_human
DUSP1  |  1843  |  CTD_human
SAA1  |  6288  |  CTD_human
VEGFA  |  7422  |  CTD_human
GSS  |  2937  |  CTD_human
SOD3  |  6649  |  CTD_human
CYP1B1  |  1545  |  CTD_human
AKR1B10  |  57016  |  CTD_human
TNFSF9  |  8744  |  CTD_human
SERPINB3  |  6317  |  CTD_human
GSTP1  |  2950  |  CTD_human
CTGF  |  1490  |  CTD_human
CCR1  |  1230  |  CTD_human
HDAC4  |  9759  |  CTD_human
CD86  |  942  |  CTD_human
PRDX6  |  9588  |  CTD_human
NQO2  |  4835  |  CTD_human
KRT4  |  3851  |  CTD_human
KRT2  |  3849  |  CTD_human
MMP8  |  4317  |  CTD_human
OSM  |  5008  |  CTD_human
AKR1C2  |  1646  |  CTD_human
HLA-DMA  |  3108  |  CTD_human
DDIT3  |  1649  |  CTD_human
GCLC  |  2729  |  CTD_human
NRG1  |  3084  |  CTD_human
IL18  |  3606  |  CTD_human
TXN  |  7295  |  CTD_human
CYP1A1  |  1543  |  CTD_human
TLR4  |  7099  |  CTD_human
SLC7A11  |  23657  |  CTD_human
MMP10  |  4319  |  CTD_human
FTH1  |  2495  |  CTD_human
AHR  |  196  |  CTD_human
GLB1  |  2720  |  CTD_human
UGT1A1  |  54658  |  CTD_human
CD44  |  960  |  CTD_human
HSPB1  |  3315  |  CTD_human
GSR  |  2936  |  CTD_human
PSMD12  |  5718  |  CTD_human
CXCR3  |  2833  |  CTD_human
HSP90AA1  |  3320  |  CTD_human
CRHR1  |  1394  |  CTD_human
KRT10  |  3858  |  CTD_human
TXNRD1  |  7296  |  CTD_human
CTSS  |  1520  |  CTD_human
FLG  |  2312  |  CTD_human
ING1  |  3621  |  CTD_human
PIR  |  8544  |  CTD_human
PI3  |  5266  |  CTD_human
TLR8  |  51311  |  CTD_human
STOML2  |  30968  |  CTD_human
TPSAB1  |  7177  |  CTD_human
KIF2C  |  11004  |  CTD_human
LCN2  |  3934  |  CTD_human
MLANA  |  2315  |  CTD_human
CCL27  |  10850  |  CTD_human
IGFBP2  |  3485  |  CTD_human
IGFBP6  |  3489  |  CTD_human
SERPINB4  |  6318  |  CTD_human
CXCL14  |  9547  |  CTD_human
FABP4  |  2167  |  CTD_human
S100A8  |  6279  |  CTD_human
UGT1A6  |  54578  |  CTD_human
CLDN1  |  9076  |  CTD_human
DEFB1  |  1672  |  CTD_human
Inferring Gene(Waiting for update.)
Text Mined Gene
Entrez_id | Symbol | Score | Resource(Total Genes:265)
51087  |  YBX2  |  DISEASES
8993  |  PGLYRP1  |  DISEASES
920  |  CD4  |  DISEASES
9817  |  KEAP1  |  DISEASES
30009  |  TBX21  |  DISEASES
7051  |  TGM1  |  DISEASES
1725  |  DHPS  |  DISEASES
4282  |  MIF  |  DISEASES
5594  |  MAPK1  |  DISEASES
25776  |  CBY1  |  DISEASES
3162  |  HMOX1  |  DISEASES
3002  |  GZMB  |  DISEASES
479  |  ATP12A  |  DISEASES
4313  |  MMP2  |  DISEASES
6367  |  CCL22  |  DISEASES
6361  |  CCL17  |  DISEASES
9333  |  TGM5  |  DISEASES
23581  |  CASP14  |  DISEASES
29124  |  LGALS13  |  DISEASES
973  |  CD79A  |  DISEASES
3982  |  LIM2  |  DISEASES
6369  |  CCL24  |  DISEASES
6348  |  CCL3  |  DISEASES
26574  |  AATF  |  DISEASES
6347  |  CCL2  |  DISEASES
3558  |  IL2  |  DISEASES
51166  |  AADAT  |  DISEASES
969  |  CD69  |  DISEASES
6404  |  SELPLG  |  DISEASES
4048  |  LTA4H  |  DISEASES
3458  |  IFNG  |  DISEASES
55907  |  CMAS  |  DISEASES
1839  |  HBEGF  |  DISEASES
3565  |  IL4  |  DISEASES
3567  |  IL5  |  DISEASES
3554  |  IL1R1  |  DISEASES
11126  |  CD160  |  DISEASES
6402  |  SELL  |  DISEASES
2946  |  GSTM2  |  DISEASES
5266  |  PI3  |  DISEASES
2806  |  GOT2  |  DISEASES
970  |  CD70  |  DISEASES
6939  |  TCF15  |  DISEASES
8698  |  S1PR4  |  DISEASES
1236  |  CCR7  |  DISEASES
391013  |  PLA2G2C  |  DISEASES
968  |  CD68  |  DISEASES
6351  |  CCL4  |  DISEASES
3848  |  KRT1  |  DISEASES
6737  |  TRIM21  |  DISEASES
6117  |  RPA1  |  DISEASES
59340  |  HRH4  |  DISEASES
1828  |  DSG1  |  DISEASES
5279  |  PIGC  |  DISEASES
3569  |  IL6  |  DISEASES
26525  |  IL36RN  |  DISEASES
23392  |  KIAA0368  |  DISEASES
5004  |  ORM1  |  DISEASES
5082  |  PDCL  |  DISEASES
6366  |  CCL21  |  DISEASES
10850  |  CCL27  |  DISEASES
2766  |  GMPR  |  DISEASES
7097  |  TLR2  |  DISEASES
1545  |  CYP1B1  |  DISEASES
23531  |  MMD  |  DISEASES
8989  |  TRPA1  |  DISEASES
6521  |  SLC4A1  |  DISEASES
495  |  ATP4A  |  DISEASES
5465  |  PPARA  |  DISEASES
3552  |  IL1A  |  DISEASES
3553  |  IL1B  |  DISEASES
6403  |  SELP  |  DISEASES
943  |  TNFRSF8  |  DISEASES
941  |  CD80  |  DISEASES
5443  |  POMC  |  DISEASES
3383  |  ICAM1  |  DISEASES
3827  |  KNG1  |  DISEASES
9175  |  MAP3K13  |  DISEASES
6897  |  TARS  |  DISEASES
23242  |  COBL  |  DISEASES
2252  |  FGF7  |  DISEASES
3067  |  HDC  |  DISEASES
3687  |  ITGAX  |  DISEASES
4059  |  BCAM  |  DISEASES
5141  |  PDE4A  |  DISEASES
56832  |  IFNK  |  DISEASES
196743  |  PAOX  |  DISEASES
710  |  SERPING1  |  DISEASES
2206  |  MS4A2  |  DISEASES
3606  |  IL18  |  DISEASES
51594  |  NBAS  |  DISEASES
64422  |  ATG3  |  DISEASES
7345  |  UCHL1  |  DISEASES
27342  |  RABGEF1  |  DISEASES
11269  |  DDX19B  |  DISEASES
114771  |  PGLYRP3  |  DISEASES
9437  |  NCR1  |  DISEASES
1234  |  CCR5  |  DISEASES
6352  |  CCL5  |  DISEASES
7412  |  VCAM1  |  DISEASES
26225  |  ARL5A  |  DISEASES
132954  |  PDCL2  |  DISEASES
152185  |  SPICE1  |  DISEASES
213  |  ALB  |  DISEASES
2150  |  F2RL1  |  DISEASES
1437  |  CSF2  |  DISEASES
2171  |  FABP5  |  DISEASES
51084  |  CRYL1  |  DISEASES
26253  |  CLEC4E  |  DISEASES
6778  |  STAT6  |  DISEASES
4597  |  MVD  |  DISEASES
3868  |  KRT16  |  DISEASES
719  |  C3AR1  |  DISEASES
6356  |  CCL11  |  DISEASES
6037  |  RNASE3  |  DISEASES
3603  |  IL16  |  DISEASES
8988  |  HSPB3  |  DISEASES
6869  |  TACR1  |  DISEASES
54360  |  CYTL1  |  DISEASES
1493  |  CTLA4  |  DISEASES
3596  |  IL13  |  DISEASES
3627  |  CXCL10  |  DISEASES
6699  |  SPRR1B  |  DISEASES
6373  |  CXCL11  |  DISEASES
1241  |  LTB4R  |  DISEASES
624  |  BDKRB2  |  DISEASES
135644  |  TRIM40  |  DISEASES
10238  |  DCAF7  |  DISEASES
3872  |  KRT17  |  DISEASES
2147  |  F2  |  DISEASES
2733  |  GLE1  |  DISEASES
3310  |  HSPA6  |  DISEASES
116512  |  MRGPRD  |  DISEASES
10713  |  USP39  |  DISEASES
64231  |  MS4A6A  |  DISEASES
8560  |  DEGS1  |  DISEASES
10170  |  DHRS9  |  DISEASES
2529  |  FUT7  |  DISEASES
4684  |  NCAM1  |  DISEASES
50619  |  DEF6  |  DISEASES
80381  |  CD276  |  DISEASES
10938  |  EHD1  |  DISEASES
6863  |  TAC1  |  DISEASES
7156  |  TOP3A  |  DISEASES
940  |  CD28  |  DISEASES
1237  |  CCR8  |  DISEASES
6097  |  RORC  |  DISEASES
338322  |  NLRP10  |  DISEASES
3563  |  IL3RA  |  DISEASES
8651  |  SOCS1  |  DISEASES
11187  |  PKP3  |  DISEASES
6401  |  SELE  |  DISEASES
942  |  CD86  |  DISEASES
2826  |  CCR10  |  DISEASES
254910  |  LCE5A  |  DISEASES
353144  |  LCE3C  |  DISEASES
10076  |  PTPRU  |  DISEASES
353142  |  LCE3A  |  DISEASES
353143  |  LCE3B  |  DISEASES
114548  |  NLRP3  |  DISEASES
200162  |  SPAG17  |  DISEASES
10626  |  TRIM16  |  DISEASES
85480  |  TSLP  |  DISEASES
3605  |  IL17A  |  DISEASES
1811  |  SLC26A3  |  DISEASES
114770  |  PGLYRP2  |  DISEASES
728  |  C5AR1  |  DISEASES
50618  |  ITSN2  |  DISEASES
85301  |  COL27A1  |  DISEASES
3683  |  ITGAL  |  DISEASES
6364  |  CCL20  |  DISEASES
57115  |  PGLYRP4  |  DISEASES
2114  |  ETS2  |  DISEASES
104  |  ADARB1  |  DISEASES
6772  |  STAT1  |  DISEASES
10367  |  MICU1  |  DISEASES
5742  |  PTGS1  |  DISEASES
10724  |  MGEA5  |  DISEASES
4283  |  CXCL9  |  DISEASES
56670  |  SUCNR1  |  DISEASES
5891  |  MOK  |  DISEASES
83881  |  MIXL1  |  DISEASES
5362  |  PLXNA2  |  DISEASES
7432  |  VIP  |  DISEASES
5788  |  PTPRC  |  DISEASES
5743  |  PTGS2  |  DISEASES
51696  |  HECA  |  DISEASES
913  |  CD1E  |  DISEASES
912  |  CD1D  |  DISEASES
6280  |  S100A9  |  DISEASES
3713  |  IVL  |  DISEASES
26239  |  LCE2B  |  DISEASES
2312  |  FLG  |  DISEASES
388697  |  HRNR  |  DISEASES
914  |  CD2  |  DISEASES
965  |  CD58  |  DISEASES
1268  |  CNR1  |  DISEASES
4803  |  NGF  |  DISEASES
3738  |  KCNA3  |  DISEASES
2316  |  FLNA  |  DISEASES
959  |  CD40LG  |  DISEASES
953  |  ENTPD1  |  DISEASES
27069  |  GHITM  |  DISEASES
958  |  CD40  |  DISEASES
4318  |  MMP9  |  DISEASES
6865  |  TACR2  |  DISEASES
2833  |  CXCR3  |  DISEASES
7099  |  TLR4  |  DISEASES
64600  |  PLA2G2F  |  DISEASES
26279  |  PLA2G2D  |  DISEASES
5322  |  PLA2G5  |  DISEASES
5320  |  PLA2G2A  |  DISEASES
30814  |  PLA2G2E  |  DISEASES
23013  |  SPEN  |  DISEASES
50943  |  FOXP3  |  DISEASES
7133  |  TNFRSF1B  |  DISEASES
11074  |  TRIM31  |  DISEASES
386653  |  IL31  |  DISEASES
442184  |  OR2B3  |  DISEASES
9308  |  CD83  |  DISEASES
2625  |  GATA3  |  DISEASES
9247  |  GCM2  |  DISEASES
1543  |  CYP1A1  |  DISEASES
90865  |  IL33  |  DISEASES
388698  |  FLG2  |  DISEASES
3903  |  LAIR1  |  DISEASES
5650  |  KLK7  |  DISEASES
2919  |  CXCL1  |  DISEASES
4901  |  NRL  |  DISEASES
3269  |  HRH1  |  DISEASES
80380  |  PDCD1LG2  |  DISEASES
594857  |  NPS  |  DISEASES
7442  |  TRPV1  |  DISEASES
2199  |  FBLN2  |  DISEASES
5150  |  PDE7A  |  DISEASES
50489  |  CD207  |  DISEASES
1638  |  DCT  |  DISEASES
3113  |  HLA-DPA1  |  DISEASES
8399  |  PLA2G10  |  DISEASES
5005  |  ORM2  |  DISEASES
720  |  C4A  |  DISEASES
55683  |  KANSL3  |  DISEASES
10107  |  TRIM10  |  DISEASES
960  |  CD44  |  DISEASES
7124  |  TNF  |  DISEASES
388372  |  CCL4L1  |  DISEASES
1154  |  CISH  |  DISEASES
116  |  ADCYAP1  |  DISEASES
3586  |  IL10  |  DISEASES
4753  |  NELL2  |  DISEASES
58494  |  JAM2  |  DISEASES
6949  |  TCOF1  |  DISEASES
2920  |  CXCL2  |  DISEASES
56413  |  LTB4R2  |  DISEASES
6188  |  RPS3  |  DISEASES
83695  |  RHNO1  |  DISEASES
55350  |  VNN3  |  DISEASES
1232  |  CCR3  |  DISEASES
9  |  NAT1  |  DISEASES
27229  |  TUBGCP4  |  DISEASES
51214  |  IGF2-AS  |  DISEASES
7955  |  RNF217-AS1  |  DISEASES
692084  |  SNORD13  |  DISEASES
26802  |  SNORD47  |  DISEASES
100128252  |  ZNF667-AS1  |  DISEASES
Locus(Waiting for update.)
Disease ID 1058
Disease contact dermatitis
Integrated Phenotype(Waiting for update.)
Text Mined Phenotype
HPO | Name | Sentences' Count(Total Phenotypes:21)
HP:0000964  |  Eczema  |  7
HP:0012393  |  Allergy  |  5
HP:0001047  |  Atopic dermatitis  |  4
HP:0000989  |  pruritis  |  2
HP:0001025  |  Hives  |  1
HP:0003765  |  Psoriasis  |  1
HP:0001880  |  Eosinophilia  |  1
HP:0002955  |  Granulomatosis  |  1
HP:0000041  |  Chordee  |  1
HP:0002315  |  Headaches  |  1
HP:0009733  |  Glioma  |  1
HP:0200039  |  Pustules  |  1
HP:0001019  |  Exfoliative dermititis  |  1
HP:0000988  |  Exanthem  |  1
HP:0002633  |  Vasculitis  |  1
HP:0010783  |  Erythema  |  1
HP:0002719  |  infections, recurrent  |  1
HP:0000716  |  Depression  |  1
HP:0002608  |  Celiac disease  |  1
HP:0011123  |  Skin inflammation  |  1
HP:0010562  |  Keloids  |  1
Disease ID 1058
Disease contact dermatitis
Manually Symptom(Waiting for update.)
Text Mined Symptom
UMLS | Name | Sentences' Count(Total Symptoms:1)
C0002111  |  allergy  |  5
Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)
All Snps(Total Genotypes:3)
snpId pubmedId geneId geneSymbol diseaseId sourceId sentence score Year geneSymbol_dbSNP CHROMOSOME POS REF ALT
rs17501010231369569076CLDN1umls:C0011616BeFreeThe CLDN1 polymorphisms rs9290927, rs893051 and rs17501010 were associated, respectively, with nickel contact sensitization in individuals without ear piercings, contact sensitization to fragrances, and with both organic compounds and nickel contact dermatitis.0.1202714422013CLDN13190308865GT
rs893051231369569076CLDN1umls:C0011616BeFreeThe CLDN1 polymorphisms rs9290927, rs893051 and rs17501010 were associated, respectively, with nickel contact sensitization in individuals without ear piercings, contact sensitization to fragrances, and with both organic compounds and nickel contact dermatitis.0.1202714422013CLDN13190321812GC
rs9290927231369569076CLDN1umls:C0011616BeFreeThe CLDN1 polymorphisms rs9290927, rs893051 and rs17501010 were associated, respectively, with nickel contact sensitization in individuals without ear piercings, contact sensitization to fragrances, and with both organic compounds and nickel contact dermatitis.0.1202714422013NA3190304727AT
GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)
GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)
Mapped by lexical matching(Total Items:0)
(Waiting for update.)
Mapped by homologous gene(Total Items:0)
(Waiting for update.)
Chemical(Total Drugs:5)
CUI ChemicalName ChemicalID CasRN DiseaseName DiseaseID DirectEvidence PubMedIDs
C0011616amcinonideC012716-dermatitis, contactMESH:D003877marker/mechanism1834432
C0011616capsaicinD002211404-86-4dermatitis, contactMESH:D003877marker/mechanism20358390
C0011616clonidineD0030004205-90-7dermatitis, contactMESH:D003877marker/mechanism6503214
C0011616glutathioneD00597870-18-8dermatitis, contactMESH:D003877therapeutic21722719
C0011616vitamin eD0148101406-18-4dermatitis, contactMESH:D003877therapeutic9675703
FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)
FDA labeling changes(Total Drugs:0)
(Waiting for update.)