PedAM

Pediatric Disease Annotations & Medicines


	conduct disorder

Disease ID	736
Disease	conduct disorder
Definition	A repetitive and persistent pattern of behavior in which the basic rights of others or major age-appropriate societal norms or rules are violated. These behaviors include aggressive conduct that causes or threatens physical harm to other people or animals, nonaggressive conduct that causes property loss or damage, deceitfulness or theft, and serious violations of rules. The onset is before age 18. (From DSM-IV, 1994)
Synonym	[x]conduct disorder, unspecified [x]conduct disorders [x]conduct disorders (disorder) conduct dis conduct disorder (disorder) conduct disorder [disease/finding] conduct disorders conduct disturbance nos disturbance of conduct nos disturbance of conduct nos (disorder) unspecified disturbance of conduct unspecified disturbance of conduct (disorder)
DOID	DOID:12995
UMLS	C0149654
MeSH	D019955
SNOMED-CT	SNOMEDCT_US_2016_09_01:430909002
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:8) C0011570 \| depression \| 4 C0003467 \| anxiety \| 2 C0036341 \| schizophrenia \| 2 C1263846 \| attention deficit hyperactivity disorder \| 2 C0003469 \| anxiety disorder \| 1 C0005586 \| bipolar disorder \| 1 C0006012 \| borderline personality disorder \| 1 C0003431 \| antisocial personality disorder \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) PDE10A \| 10846 \| GWASCAT C1QTNF7 \| 114905 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:38) 646479 \| ADAM24P \| infer 125 \| ADH1B \| infer 58504 \| ARHGAP22 \| infer 114905 \| C1QTNF7 \| infer 56934 \| CA10 \| infer 57545 \| CC2D2A \| infer 10602 \| CDC42EP3 \| infer 2018 \| EMX2 \| infer 2072 \| ERCC4 \| infer 339742 \| FAM201B \| infer 9955 \| HS3ST3A1 \| infer 3736 \| KCNA1 \| infer 4128 \| MAOA \| infer 55784 \| MCTP2 \| infer 9258 \| MFHAS1 \| infer 51594 \| NBAS \| infer 10846 \| PDE10A \| infer 152926 \| PPM1K \| infer 122888 \| PTBP1P \| infer 54715 \| RBFOX1 \| infer 6016 \| RIT1 \| infer 6014 \| RIT2 \| infer 57484 \| RNF150 \| infer 100271439 \| RPL21P111 \| infer 100271015 \| RPL37P10 \| infer 644119 \| RPS14P9 \| infer 6229 \| RPS24 \| infer 100271597 \| RPS3AP42 \| infer 6404 \| SELPLG \| infer 344371 \| SLC25A5P2 \| infer 11000 \| SLC27A3 \| infer 6529 \| SLC6A1 \| infer 6532 \| SLC6A4 \| infer 6546 \| SLC8A1 \| infer 7903 \| ST8SIA4 \| infer 84969 \| TOX2 \| infer 7704 \| ZBTB16 \| infer 27309 \| ZNF330 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:118) 27184 \| DISC2 \| DISEASES 22846 \| VASH1 \| DISEASES 1815 \| DRD4 \| DISEASES 10278 \| EFS \| DISEASES 5020 \| OXT \| DISEASES 6530 \| SLC6A2 \| DISEASES 6822 \| SULT2A1 \| DISEASES 6804 \| STX1A \| DISEASES 55907 \| CMAS \| DISEASES 2908 \| NR3C1 \| DISEASES 374291 \| NDUFS7 \| DISEASES 1088 \| CEACAM8 \| DISEASES 7166 \| TPH1 \| DISEASES 6616 \| SNAP25 \| DISEASES 10894 \| LYVE1 \| DISEASES 102 \| ADAM10 \| DISEASES 1588 \| CYP19A1 \| DISEASES 10017 \| BCL2L10 \| DISEASES 23314 \| SATB2 \| DISEASES 6857 \| SYT1 \| DISEASES 6532 \| SLC6A4 \| DISEASES 217 \| ALDH2 \| DISEASES 5934 \| RBL2 \| DISEASES 6505 \| SLC1A1 \| DISEASES 2033 \| EP300 \| DISEASES 5582 \| PRKCG \| DISEASES 7301 \| TYRO3 \| DISEASES 56925 \| LXN \| DISEASES 119 \| ADD2 \| DISEASES 1475 \| CSTA \| DISEASES 127 \| ADH4 \| DISEASES 55749 \| CCAR1 \| DISEASES 150094 \| SIK1 \| DISEASES 6531 \| SLC6A3 \| DISEASES 52 \| ACP1 \| DISEASES 275 \| AMT \| DISEASES 3358 \| HTR2C \| DISEASES 150 \| ADRA2A \| DISEASES 22934 \| RPIA \| DISEASES 23643 \| LY96 \| DISEASES 909 \| CD1A \| DISEASES 10417 \| SPON2 \| DISEASES 114905 \| C1QTNF7 \| DISEASES 552 \| AVPR1A \| DISEASES 2562 \| GABRB3 \| DISEASES 3611 \| ILK \| DISEASES 1138 \| CHRNA5 \| DISEASES 89832 \| CHRFAM7A \| DISEASES 4054 \| LTBP3 \| DISEASES 1816 \| DRD5 \| DISEASES 125 \| ADH1B \| DISEASES 3913 \| LAMB2 \| DISEASES 26512 \| INTS6 \| DISEASES 2688 \| GH1 \| DISEASES 6844 \| VAMP2 \| DISEASES 1776 \| DNASE1L3 \| DISEASES 1129 \| CHRM2 \| DISEASES 9520 \| NPEPPS \| DISEASES 23212 \| RRS1 \| DISEASES 5021 \| OXTR \| DISEASES 1812 \| DRD1 \| DISEASES 9735 \| KNTC1 \| DISEASES 8905 \| AP1S2 \| DISEASES 121278 \| TPH2 \| DISEASES 277 \| AMY1B \| DISEASES 2567 \| GABRG3 \| DISEASES 23762 \| OSBP2 \| DISEASES 10810 \| WASF3 \| DISEASES 135 \| ADORA2A \| DISEASES 57142 \| RTN4 \| DISEASES 8835 \| SOCS2 \| DISEASES 4521 \| NUDT1 \| DISEASES 4128 \| MAOA \| DISEASES 4929 \| NR4A2 \| DISEASES 2879 \| GPX4 \| DISEASES 23481 \| PES1 \| DISEASES 2555 \| GABRA2 \| DISEASES 8794 \| TNFRSF10C \| DISEASES 1996 \| ELAVL4 \| DISEASES 83658 \| DYNLRB1 \| DISEASES 8936 \| WASF1 \| DISEASES 79947 \| DHDDS \| DISEASES 5646 \| PRSS3 \| DISEASES 1312 \| COMT \| DISEASES 1813 \| DRD2 \| DISEASES 7179 \| TPTE \| DISEASES 8564 \| KMO \| DISEASES 910 \| CD1B \| DISEASES 911 \| CD1C \| DISEASES 103 \| ADAR \| DISEASES 1081 \| CGA \| DISEASES 3351 \| HTR1B \| DISEASES 278 \| AMY1C \| DISEASES 276 \| AMY1A \| DISEASES 115004 \| MB21D1 \| DISEASES 2902 \| GRIN1 \| DISEASES 10718 \| NRG3 \| DISEASES 11128 \| POLR3A \| DISEASES 8518 \| IKBKAP \| DISEASES 4129 \| MAOB \| DISEASES 8544 \| PIR \| DISEASES 1621 \| DBH \| DISEASES 64115 \| C10orf54 \| DISEASES 4905 \| NSF \| DISEASES 815 \| CAMK2A \| DISEASES 3098 \| HK1 \| DISEASES 1135 \| CHRNA2 \| DISEASES 348180 \| CTU2 \| DISEASES 4988 \| OPRM1 \| DISEASES 10163 \| WASF2 \| DISEASES 54900 \| LAX1 \| DISEASES 1139 \| CHRNA7 \| DISEASES 6092 \| ROBO2 \| DISEASES 23089 \| PEG10 \| DISEASES 4043 \| LRPAP1 \| DISEASES 55733 \| HHAT \| DISEASES 4850 \| CNOT4 \| DISEASES 104355217 \| ERICD \| DISEASES
Locus	(Waiting for update.)

Disease ID	736
Disease	conduct disorder
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:14) HP:0000716 \| Depression \| 4 HP:0007018 \| Attention deficits \| 3 HP:0002500 \| Leukoaraiosis \| 2 HP:0100753 \| Schizophrenia \| 2 HP:0000739 \| Anxiety \| 2 HP:0000718 \| Aggressive behaviour \| 2 HP:0012075 \| Personality disorder \| 2 HP:0012076 \| Borderline personality disorder \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0000712 \| Emotional instability \| 1 HP:0007302 \| Bipolar disorder \| 1 HP:0000752 \| Hyperactive behavior \| 1 HP:0000708 \| Behavioral problems \| 1 HP:0000805 \| Enuresis \| 1

Disease ID	736
Disease	conduct disorder
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:35)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10776612	20585324	58504	ARHGAP22	umls:C0149654	GAD	[Genome-wide association study of conduct disorder symptomatology.]	0.002367032	2011	ARHGAP22	10	48527518	C	T
rs12302829	20585324	3736	KCNA1	umls:C0149654	GAD	[Genome-wide association study of conduct disorder symptomatology.]	0.002367032	2011	NA	12	5031318	A	G
rs13188771	18846501	7903	ST8SIA4	umls:C0149654	GAD	[Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.]	0.002367032	2008	LOC105379102	5	101612841	C	A
rs1550057	20585324	57484	RNF150	umls:C0149654	GAD	[Genome-wide association study of conduct disorder symptomatology.]	0.002367032	2011	RNF150	4	141196270	A	G
rs16831128	20585324	339742	FAM201B	umls:C0149654	GAD	[Genome-wide association study of conduct disorder symptomatology.]	0.002367032	2011	NA	2	132386819	A	G
rs16891867	20585324	114905	C1QTNF7	umls:C0149654	GWASCAT	We find four markers that meet the criteria for genome-wide significance (P<5 × 10(-8)) with the CD symptom count, two of which are located in the gene C1QTNF7 (C1q and tumor necrosis factor-related protein 7).	0.122638474	2011	C1QTNF7;LOC101929095	4	15395740	A	G
rs16891867	20585324	114905	C1QTNF7	umls:C0149654	GAD	[We find four markers that meet the criteria for genome-wide significance (P<5 A 10(-8)) with the CD symptom count, two of which are located in the gene C1QTNF7 (C1q and tumor necrosis factor-related protein 7).]	0.122638474	2011	C1QTNF7;LOC101929095	4	15395740	A	G
rs17007017	20585324	27309	ZNF330	umls:C0149654	GAD	[Genome-wide association study of conduct disorder symptomatology.]	0.002367032	2011	ZNF330	4	141221575	A	G
rs17664267	18846501	6014	RIT2	umls:C0149654	GAD	[Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.]	0.002367032	2008	NA	18	43228833	G	T
rs1789891	18846501	125	ADH1B	umls:C0149654	GAD	[Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.]	0.002367032	2008	NA	4	99329262	C	A
rs1861046	20585324	114905	C1QTNF7	umls:C0149654	GAD	[We find four markers that meet the criteria for genome-wide significance (P<5 A 10(-8)) with the CD symptom count, two of which are located in the gene C1QTNF7 (C1q and tumor necrosis factor-related protein 7).]	0.122638474	2011	C1QTNF7;LOC101929095	4	15396282	G	A
rs1861046	20585324	114905	C1QTNF7	umls:C0149654	GWASCAT	We find four markers that meet the criteria for genome-wide significance (P<5 × 10(-8)) with the CD symptom count, two of which are located in the gene C1QTNF7 (C1q and tumor necrosis factor-related protein 7).	0.122638474	2011	C1QTNF7;LOC101929095	4	15396282	G	A
rs1861050	20585324	57545	CC2D2A	umls:C0149654	GAD	[Genome-wide association study of conduct disorder symptomatology.]	0.002367032	2011	CC2D2A	4	15480736	C	T
rs2184898	20585324	2018	EMX2	umls:C0149654	GAD	[Genome-wide association study of conduct disorder symptomatology.]	0.002367032	2011	NA	10	117658593	G	A
rs2282301	18846501	6016	RIT1	umls:C0149654	GAD	[Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.]	0.002367032	2008	RIT1	1	155898834	G	A
rs2395528	18846501	6229	RPS24	umls:C0149654	GAD	[Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.]	0.002367032	2008	NA	10	78341104	T	C
rs279871	19783384	2555	GABRA2	umls:C0149654	BeFree	We sought to replicate previous findings and test for an association between a single nucleotide polymorphism (SNP) in the GABRA2 gene (rs279871) and CD among adolescents.	0.000814326	2010	GABRA2	4	46303716	T	C
rs3136202	20585324	2072	ERCC4	umls:C0149654	GAD	[Genome-wide association study of conduct disorder symptomatology.]	0.002367032	2011	ERCC4	16	13944317	G	A
rs332034	18846501	9258	MFHAS1	umls:C0149654	GAD	[Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.]	0.002367032	2008	MFHAS1	8	8859497	T	C
rs4321143	18846501	55784	MCTP2	umls:C0149654	GAD	[Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.]	0.002367032	2008	LOC105370996	15	95613139	A	G
rs4434872	20585324	343052	LOC343052	umls:C0149654	GAD	[Genome-wide association study of conduct disorder symptomatology.]	0.002367032	2011	LOC105371448	1	153801800	T	C
rs4434872	20585324	11000	SLC27A3	umls:C0149654	GAD	[Genome-wide association study of conduct disorder symptomatology.]	0.002367032	2011	LOC105371448	1	153801800	T	C
rs4680	19997043	1312	COMT	umls:C0149654	BeFree	Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents.	0.001085767	2010	COMT;MIR4761	22	19963748	G	A
rs4680	22270685	1312	COMT	umls:C0149654	BeFree	COMT Val(158)Met polymorphism has been associated with both symptoms of attention-deficit/hyperactivity disorder (ADHD) and disruptive behavior disorders (DBD): that is, oppositional defiant disorder (ODD) and conduct disorder (CD) often comorbid with ADHD.	0.001085767	2012	COMT;MIR4761	22	19963748	G	A
rs4792394	20585324	9955	HS3ST3A1	umls:C0149654	GAD	[Genome-wide association study of conduct disorder symptomatology.]	0.002367032	2011	LOC100506974	17	13781600	C	A
rs6031252	20585324	84969	TOX2	umls:C0149654	GAD	[Genome-wide association study of conduct disorder symptomatology.]	0.002367032	2011	TOX2	20	43945182	C	A
rs604381	18846501	10602	CDC42EP3	umls:C0149654	GAD	[Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.]	0.002367032	2008	NA	2	37749874	G	T
rs6500744	18846501	54715	RBFOX1	umls:C0149654	GAD	[Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.]	0.002367032	2008	RBFOX1	16	6063660	C	T
rs7581919	20585324	51594	NBAS	umls:C0149654	GAD	[Genome-wide association study of conduct disorder symptomatology.]	0.002367032	2011	NBAS	2	15524632	C	T
rs7762160	20585324	10846	PDE10A	umls:C0149654	GAD	[Genome-wide association study of conduct disorder symptomatology.]	0.122367032	2011	PDE10A	6	165601943	T	C
rs7762160	20585324	10846	PDE10A	umls:C0149654	GWASCAT	Genome-wide association study of conduct disorder symptomatology.	0.122367032	2011	PDE10A	6	165601943	T	C
rs8073783	18846501	56934	CA10	umls:C0149654	GAD	[Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.]	0.002367032	2008	NA	17	53160580	C	T
rs8179116	20585324	6404	SELPLG	umls:C0149654	GAD	[Genome-wide association study of conduct disorder symptomatology.]	0.002367032	2011	SELPLG;LOC105369968	12	108631651	C	T
rs893971	18846501	152926	PPM1K	umls:C0149654	GAD	[Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.]	0.002367032	2008	PPM1K	4	88282518	A	G
rs9990174	18846501	6529	SLC6A1	umls:C0149654	GAD	[Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.]	0.002367032	2008	SLC6A1	3	10998753	G	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:111)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	10049177	rs12140058	T	G	rs12140058	23077488	0.000858	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
1	153774276	rs4434872	T	C	rs4434872	20585324	8.00E-06	NA	0.08	[NA] unit increase	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
1	155868625	rs2282301	G	A	rs2282301	18846501	7.00E-06	NA	2.88	[NA] unit increase	909 European ancestry trios	European(909)	ALL(909)	EUR(909)	ALL(909)	Conduct disorder (interaction)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	NA	NA	Conduct disorder	rs2282301-A	NA	G	RIT1
1	242208009	rs10754748	G	A	rs10754748	23077488	0.000356	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
2	15664756	rs7581919	C	T	rs7581919	20585324	8.00E-06	NA	1.85	[1.41-2.43]	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
2	35526918	rs6750486	C	T	rs6750486	20585324	6.00E-06	NA	0.1	[NA] unit increase	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
2	37977017	rs604381	G	T	rs604381	18846501	8.00E-06	NA	1.26	[NA] unit increase	909 European ancestry trios	European(909)	ALL(909)	EUR(909)	ALL(909)	Conduct disorder (interaction)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	NA	NA	Conduct disorder	rs604381-A	NA	A	NA
2	42004997	rs719593	A	G	rs719593	18846501	5.00E-06	NA	2.05	[NA] unit decrease	909 European ancestry trios	European(909)	ALL(909)	EUR(909)	ALL(909)	Conduct disorder (interaction)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	NA	NA	Conduct disorder	rs719593-T	NA	T	NA
2	84245168	rs13398848	A	G	rs13398848	20585324	1.00E-06	AA	0.17	[NA] unit increase	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	rs13398848-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
2	84245168	rs13398848	A	G	rs13398848	20585324	5.00E-06	NA	1.59	[1.30-1.95]	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
2	86392768	rs7561888	A	G	rs7561888	23077488	0.00000546	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
2	86443208	rs17510310	C	T	rs17510310	23077488	0.00000663	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
2	130916415	rs2084784	A	G	rs2084784	23077488	0.000272	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G,A
2	130952038	rs13000721	G	A	rs13000721	23077488	0.000077	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
2	133144392	rs16831128	A	G	rs16831128	20585324	4.00E-07	NA	1.45	[1.26-1.67]	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
2	133144392	rs16831128	A	G	rs16831128	20585324	5.00E-06	NA	0.08	[NA] unit increase	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	rs16831128-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
2	140655121	rs9287528	G	T	rs9287528	23077488	0.000013	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
2	140657370	rs11901615	T	C	rs11901615	23077488	0.0000158	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
2	154223946	rs11682518	G	T	rs11682518	20345837	8.55E-04	Antisocial behavior and callous-unemotional behavior	NA	NA	600 British samples	British(600)	ALL(600)	EUR(600)	ALL(600)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Twin Study	Research Support, Non-U.S. Gov't	G
2	160202268	rs3771684	C	T	rs3771684	23077488	0.00000871	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
3	11040439	rs9990174	G	T	rs9990174	18846501	6.00E-06	NA	2.52	[NA] unit decrease	909 European ancestry trios	European(909)	ALL(909)	EUR(909)	ALL(909)	Conduct disorder (interaction)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	NA	NA	Conduct disorder	rs9990174-T	NA	G	SLC6A1
3	100178459	rs4928050	G	A	rs4928050	23077488	0.0000347	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
3	109739262	rs17722374	C	T	rs17722374	23077488	0.00000715	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
4	15397364	rs16891867	A	G	rs16891867	20585324	3.00E-09	NA	0.15	[NA] unit increase	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
4	15397364	rs16891867	A	G	rs16891867	20585324	4.00E-06	AA	0.15	[NA] unit increase	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	rs16891867-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
4	15397906	rs1861046	G	A	rs1861046	20585324	6.00E-08	NA	1.65	[1.38-1.98]	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
4	15482360	rs1861050	C	T	rs1861050	20585324	8.00E-06	NA	1.63	[1.31-2.01]	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
4	89203670	rs893971	A	G	rs893971	18846501	7.00E-06	NA	1.15	[NA] unit decrease	909 European ancestry trios	European(909)	ALL(909)	EUR(909)	ALL(909)	Conduct disorder (interaction)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	NA	NA	Conduct disorder	rs893971-T	NA	T	PPM1K
4	100250419	rs1789891	C	A	rs1789891	18846501	3.00E-06	NA	1.47	[NA] unit increase	909 European ancestry trios	European(909)	ALL(909)	EUR(909)	ALL(909)	Conduct disorder (interaction)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	NA	NA	Conduct disorder	rs1789891-A	NA	C	NA
4	103383107	rs17008528	G	A	rs17008528	23077488	0.0000162	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
4	142117424	rs1550057	A	G	rs1550057	20585324	4.00E-06	NA	1.39	[1.21-1.61]	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
4	142142729	rs17007017	A	G	rs17007017	20585324	7.00E-06	NA	1.34	[1.18-1.52]	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
4	152399324	rs4479686	C	T	rs4479686	20345837	2.58E-04	Antisocial behavior and callous-unemotional behavior	NA	NA	600 British samples	British(600)	ALL(600)	EUR(600)	ALL(600)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Twin Study	Research Support, Non-U.S. Gov't	T
5	62556494	rs349493	G	C	rs349493	23077488	0.0000138	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
5	62558371	rs401859	A	G	rs401859	23077488	0.0000113	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
5	62558482	rs373666	G	C	rs373666	23077488	0.0000112	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
5	62559094	rs462861	G	T	rs462861	23077488	0.0000101	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
5	62559408	rs460325	A	G	rs460325	23077488	0.0000101	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
5	62559466	rs460949	T	C	rs460949	23077488	0.00001	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
5	62559827	rs455575	G	T	rs455575	23077488	0.0000154	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
5	62560532	rs458362	A	G	rs458362	23077488	0.0000097	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
5	62560987	rs1676146	C	T	rs1676146	23077488	0.00000968	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
5	62561826	rs434640	T	A	rs434640	23077488	0.000015	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
5	62564660	rs443543	A	T	rs443543	23077488	0.00000961	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
5	62566536	rs418226	T	G	rs418226	23077488	0.0000149	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
5	62566742	rs392246	G	A	rs392246	23077488	0.0000149	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
5	62566931	rs387996	G	A	rs387996	23077488	0.0000149	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
5	62567045	rs427421	C	A	rs427421	23077488	0.0000148	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
5	62570415	rs444037	C	A	rs444037	23077488	0.0000123	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
5	62570637	rs369747	G	A	rs369747	23077488	0.0000147	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C,T
5	62576964	rs424672	G	A	rs424672	23077488	0.0000144	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
5	62577126	rs409363	G	C	rs409363	23077488	0.0000143	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
5	62582833	rs386661	G	C	rs386661	23077488	0.0000169	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
5	62584515	rs346431	T	A	rs346431	23077488	0.0000169	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
5	62596244	rs346425	T	C	rs346425	23077488	0.000000251	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
5	100948545	rs13188771	C	A	rs13188771	18846501	2.00E-06	NA	4.24	[NA] unit decrease	909 European ancestry trios	European(909)	ALL(909)	EUR(909)	ALL(909)	Conduct disorder (interaction)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	NA	NA	Conduct disorder	rs13188771-A	NA	C	NA
5	146683300	rs11956931	A	T	rs11956931	23077488	0.00000879	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
5	165957086	rs2122554	T	G	rs2122554	20585324	3.00E-06	NA	0.1	[NA] unit decrease	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
6	67799924	rs13202756	A	C	rs13202756	23077488	0.00000164	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
6	77788834	rs9343557	T	C	rs9343557	20345837	4.02E-04	Antisocial behavior and callous-unemotional behavior	NA	NA	600 British samples	British(600)	ALL(600)	EUR(600)	ALL(600)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Twin Study	Research Support, Non-U.S. Gov't	T
6	88975977	rs16880441	C	G	rs16880441	18846501	9.00E-06	NA	1.63	[NA] unit increase	909 European ancestry trios	European(909)	ALL(909)	EUR(909)	ALL(909)	Conduct disorder (interaction)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	NA	NA	Conduct disorder	rs16880441-G	NA	C	NA
6	166015431	rs7762160	T	C	rs7762160	20585324	1.00E-06	NA	0.07	[NA] unit increase	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
7	80280117	rs3211834	A	C	rs3211834	23077488	0.000297	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
8	3300163	rs200131128	CG	C	rs6558776	23077488	0.00000629	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
8	3300163	rs6558776	C	T	rs6558776	23077488	0.00000629	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
8	8717007	rs332034	T	C	rs332034	18846501	6.00E-06	NA	1.05	[NA] unit increase	909 European ancestry trios	European(909)	ALL(909)	EUR(909)	ALL(909)	Conduct disorder (interaction)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	NA	NA	Conduct disorder	rs332034-A	NA	A	MFHAS1
8	17329827	rs2720508	C	T	rs2720508	20585324	7.00E-06	NA	1.61	[1.31-1.97]	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
8	29419713	rs10103840	C	A	rs10103840	20345837	5.05E-04	Antisocial behavior and callous-unemotional behavior	NA	NA	600 British samples	British(600)	ALL(600)	EUR(600)	ALL(600)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Twin Study	Research Support, Non-U.S. Gov't	C
10	49735563	rs10776612	C	T	rs10776612	20585324	2.00E-06	NA	1.33	[1.18-1.49]	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
10	79492970	rs12761718	C	T	rs12761718	20345837	4.77E-05	Antisocial behavior and callous-unemotional behavior	NA	NA	600 British samples	British(600)	ALL(600)	EUR(600)	ALL(600)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Twin Study	Research Support, Non-U.S. Gov't	C
10	80100861	rs2395528	T	C	rs2395528	18846501	6.00E-06	NA	1.46	[NA] unit decrease	909 European ancestry trios	European(909)	ALL(909)	EUR(909)	ALL(909)	Conduct disorder (interaction)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	NA	NA	Conduct disorder	rs2395528-T	NA	C	NA
10	119418104	rs2184898	G	A	rs2184898	20585324	3.00E-06	NA	1.33	[1.18-1.50]	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
11	79858863	rs1893815	G	T	rs1893815	20345837	6.20E-05	Antisocial behavior and callous-unemotional behavior	NA	NA	600 British samples	British(600)	ALL(600)	EUR(600)	ALL(600)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Twin Study	Research Support, Non-U.S. Gov't	T
11	92651002	rs7950811	C	A	rs7950811	20585324	1.00E-08	NA	0.16	[NA] unit increase	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	rs7950811-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
11	92651002	rs7950811	C	A	rs7950811	20585324	9.00E-07	NA	1.65	[1.35-2.00]	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
11	113961762	rs17116334	C	T	rs17116334	18846501	9.00E-06	NA	1.3	[NA] unit increase	909 European ancestry trios	European(909)	ALL(909)	EUR(909)	ALL(909)	Conduct disorder (interaction)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	NA	NA	Conduct disorder	rs17116334-T	NA	C	ZBTB16
11	130094199	rs4936094	G	A	rs4936094	23077488	0.000755	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
12	5140484	rs12302829	A	G	rs12302829	20585324	8.00E-06	NA	0.35	[NA] unit decrease	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
12	67599863	rs2917849	A	G	rs2917849	23077488	0.00000479	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
12	67601182	rs11176629	G	T	rs11176629	23077488	0.00000477	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
12	67603681	rs1657978	C	T	rs1657978	23077488	0.00000478	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
12	67612129	rs775313	G	A	rs775313	23077488	0.00000479	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
12	109025427	rs8179116	C	T	rs8179116	20585324	3.00E-06	NA	0.23	[NA] unit increase	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
13	79410574	rs11838918	T	C	rs11838918	20585324	1.00E-08	NA	0.28	[NA] unit increase	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	rs11838918-C	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
13	79410574	rs11838918	T	C	rs11838918	20585324	3.00E-06	NA	2.26	[1.61-3.18]	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
13	79410574	rs11838918	T	C	rs11838918	20585324	3.00E-07	AA	0.28	[NA] unit increase	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	rs11838918-C	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
14	54890379	rs3204303	C	A	rs3204303	23077488	0.0000874	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
14	54920203	rs17127582	C	T	rs17127582	23077488	0.000192	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
14	65747759	rs1256531	A	G	rs1256531	20585324	4.00E-06	NA	0.09	[NA] unit increase	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
14	91112078	rs942746	C	T	rs942746	23077488	0.00000341	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
14	91113471	rs2277512	G	A	rs2277512	23077488	0.00000855	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
14	97374996	rs1385551	C	T	rs1385551	23077488	0.00000963	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
15	58210820	rs11637779	T	C	rs11637779	20345837	4.34E-04	Antisocial behavior and callous-unemotional behavior	NA	NA	600 British samples	British(600)	ALL(600)	EUR(600)	ALL(600)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Twin Study	Research Support, Non-U.S. Gov't	T
15	83263756	rs3970696	T	A	rs3970696	23077488	0.0000914	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
15	90771704	rs3751656	G	A	rs3751656	23077488	0.00000244	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
15	90773059	rs3829490	C	T	rs3829490	23077488	0.00000174	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
15	90806140	rs9920862	G	T	rs9920862	23077488	0.0000124	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
15	96156368	rs4321143	A	G	rs4321143	18846501	7.00E-06	NA	1.13	[NA] unit increase	909 European ancestry trios	European(909)	ALL(909)	EUR(909)	ALL(909)	Conduct disorder (interaction)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	NA	NA	Conduct disorder	rs4321143-G	NA	G	NA
16	6113661	rs6500744	C	T	rs6500744	18846501	3.00E-06	NA	0.91	[NA] unit increase	909 European ancestry trios	European(909)	ALL(909)	EUR(909)	ALL(909)	Conduct disorder (interaction)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	NA	NA	Conduct disorder	rs6500744-C	NA	C	RBFOX1
16	14038174	rs3136202	G	A	rs3136202	20585324	6.00E-06	NA	0.07	[NA] unit decrease	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
16	85817324	rs11860152	G	A	rs11860152	23077488	0.0000106	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
16	85818418	rs11866179	A	C	rs11866179	23077488	0.0000107	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
16	85820202	rs896253	G	A	rs896253	23077488	0.0000112	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
17	13684917	rs4792394	C	A	rs4792394	20585324	9.00E-06	NA	0.06	[NA] unit decrease	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
17	51237941	rs8073783	C	T	rs8073783	18846501	8.00E-06	NA	1.76	[NA] unit decrease	909 European ancestry trios	European(909)	ALL(909)	EUR(909)	ALL(909)	Conduct disorder (interaction)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	NA	NA	Conduct disorder	rs8073783-C	NA	C	NA
18	40808798	rs17664267	G	T	rs17664267	18846501	7.00E-06	NA	1.39	[NA] unit increase	909 European ancestry trios	European(909)	ALL(909)	EUR(909)	ALL(909)	Conduct disorder (interaction)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	NA	NA	Conduct disorder	rs17664267-T	NA	G	NA
20	31876510	rs6119363	C	T	rs6119363	23077488	0.0000114	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
20	42573822	rs6031252	C	A	rs6031252	20585324	6.00E-06	NA	0.11	[NA] unit decrease	872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls	European,African American(3963)	ALL(3963)	EUR,AFR(3963)	ALL(3963)	Conduct disorder (symptom count)	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	D019955	Conduct Disorder	EFOID:0004216	conduct disorder	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
21	38724311	rs2835702	T	C	rs2835702	23077488	0.000000584	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
21	38727277	rs12106331	A	G	rs12106331	23077488	0.000000569	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
21	38861833	rs2835771	C	T	rs2835771	23077488	0.0000105	NA	NA	NA	4816 individuals from 2227 families	NOPOP(4816)	ALL(4816)	NOPOP(4816)	ALL(4816)	Antisocial behavior	HPOID:0100851	Abnormal emotion/affect behavior	DOID:12995	conduct disorder	NA	NA	NA	NA	Conduct disorder	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:12)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0149654	chlorpromazine	D002746	50-53-3	conduct disorder	MESH:D019955	therapeutic	15266186
C0149654	clonidine	D003000	4205-90-7	conduct disorder	MESH:D019955	marker/mechanism	9031564
C0149654	clonidine	D003000	4205-90-7	conduct disorder	MESH:D019955	therapeutic	10660814
C0149654	clozapine	D003024	5786-21-0	conduct disorder	MESH:D019955	therapeutic	10581982
C0149654	diethylstilbestrol	D004054	56-53-1	conduct disorder	MESH:D019955	marker/mechanism	16307867
C0149654	fluoxetine	D005473	54910-89-3	conduct disorder	MESH:D019955	therapeutic	12046001
C0149654	haloperidol	D006220	52-86-8	conduct disorder	MESH:D019955	therapeutic	6428371
C0149654	imipramine	D007099	50-49-7	conduct disorder	MESH:D019955	therapeutic	7691178
C0149654	linezolid	D000069349	-	conduct disorder	MESH:D019955	marker/mechanism	14742796
C0149654	methylphenidate	D008774	113-45-1	conduct disorder	MESH:D019955	therapeutic	10660814
C0149654	nicotine	D009538	-	conduct disorder	MESH:D019955	marker/mechanism	19628140
C0149654	valproic acid	D014635	99-66-1	conduct disorder	MESH:D019955	therapeutic	14658966

FDA approved drug and dosage information(Total Drugs:9)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D019955	zyvox	linezolid	400MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	TABLET;ORAL	Discontinued	None	Yes	No
MESH:D019955	zyvox	linezolid	200MG/100ML (2MG/ML)	SOLUTION;IV (INFUSION)	Prescription	AP	Yes	No
MESH:D019955	zyvox	linezolid	100MG/5ML	FOR SUSPENSION;ORAL	Prescription	AB	Yes	Yes
MESH:D019955	zyvox	linezolid	400MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	TABLET;ORAL	Discontinued	None	Yes	No
MESH:D019955	zyvox	linezolid	200MG/100ML (2MG/ML)	SOLUTION;IV (INFUSION)	Prescription	AP	Yes	No
MESH:D019955	zyvox	linezolid	100MG/5ML	FOR SUSPENSION;ORAL	Prescription	AB	Yes	Yes
MESH:D019955	daytrana	methylphenidate	10MG/9HR (1.1MG/HR)	FILM, EXTENDED RELEASE;TRANSDERMAL	Prescription	None	Yes	No
MESH:D019955	daytrana	methylphenidate	10MG/9HR (1.1MG/HR)	FILM, EXTENDED RELEASE;TRANSDERMAL	Prescription	None	Yes	No
MESH:D019955	daytrana	methylphenidate	10MG/9HR (1.1MG/HR)	FILM, EXTENDED RELEASE;TRANSDERMAL	Prescription	None	Yes	No

FDA labeling changes(Total Drugs:9)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D019955	12/19/2002	zyvox	linezolid	Nosocomial pneumonia, community-acquired pneumonia, complicated and uncomplicated skin and skin structure infections, and vancomycin-resistant infections caused by susceptible strains	Extended age range down to birth for nosocomial pneumonia, community-acquired pneumonia, complicated skin and skin structure infections and vancomycin-resistant infections. Safety and efficacy extrapolated from studies in adults and supported by PK and comparator-controlled studies in patients from birth to 11 years Extended age range down to 5 years of age for uncomplicated skin and skin structure infections based upon a comparator-controlled study in 5 to 17 year olds Clearance of linezolid varies as a function of age; As age of pediatric patients increases, clearance gradually decreases, and by adolescence mean clearance values approach those observed in adults Pediatric patients exhibit wider variability in clearance and systemic exposure (AUC) compared with adults New every 8 hours dosing regimen for pediatric patients birth to 11 years of age and every 12 hours dosing regimen for pediatric patients 12 years and older Information on PK parameters, AE profile, laboratory changes, dosing, and clinical studies	Labeling	B	-	-	-	Pfizer	11/2/2005	FALSE'
MESH:D019955	12/19/2002	zyvox	linezolid	Nosocomial pneumonia, community-acquired pneumonia, complicated and uncomplicated skin and skin structure infections, and vancomycin-resistant infections caused by susceptible strains	Extended age range down to birth for nosocomial pneumonia, community-acquired pneumonia, complicated skin and skin structure infections and vancomycin-resistant infections. Safety and efficacy extrapolated from studies in adults and supported by PK and comparator-controlled studies in patients from birth to 11 years Extended age range down to 5 years of age for uncomplicated skin and skin structure infections based upon a comparator-controlled study in 5 to 17 year olds Clearance of linezolid varies as a function of age; As age of pediatric patients increases, clearance gradually decreases, and by adolescence mean clearance values approach those observed in adults Pediatric patients exhibit wider variability in clearance and systemic exposure (AUC) compared with adults New every 8 hours dosing regimen for pediatric patients birth to 11 years of age and every 12 hours dosing regimen for pediatric patients 12 years and older Information on PK parameters, AE profile, laboratory changes, dosing, and clinical studies	Labeling	B	-	-	-	Pfizer	11/2/2005	FALSE'
MESH:D019955	12/19/2002	zyvox	linezolid	Nosocomial pneumonia, community-acquired pneumonia, complicated and uncomplicated skin and skin structure infections, and vancomycin-resistant infections caused by susceptible strains	Extended age range down to birth for nosocomial pneumonia, community-acquired pneumonia, complicated skin and skin structure infections and vancomycin-resistant infections. Safety and efficacy extrapolated from studies in adults and supported by PK and comparator-controlled studies in patients from birth to 11 years Extended age range down to 5 years of age for uncomplicated skin and skin structure infections based upon a comparator-controlled study in 5 to 17 year olds Clearance of linezolid varies as a function of age; As age of pediatric patients increases, clearance gradually decreases, and by adolescence mean clearance values approach those observed in adults Pediatric patients exhibit wider variability in clearance and systemic exposure (AUC) compared with adults New every 8 hours dosing regimen for pediatric patients birth to 11 years of age and every 12 hours dosing regimen for pediatric patients 12 years and older Information on PK parameters, AE profile, laboratory changes, dosing, and clinical studies	Labeling	B	-	-	-	Pfizer	11/2/2005	FALSE'
MESH:D019955	12/5/2005	zyvox	linezolid	Central nervous system infections	PK data in pediatric patients with ventriculoperitoneal shunts showed variable cerebrospinal fluid (CSF) concentrations; therapeutic concentrations were not consistently achieved or maintained in the CSF Use of linezolid for the empiric treatment of pediatric patients with central nervous system infections is not recommended Additional information on efficacy in pediatric patients with infectious vancomycin-resistant Enterococcus faecium	Labeling	B	-	-	-	Pfizer	11/2/2005	FALSE'
MESH:D019955	12/5/2005	zyvox	linezolid	Central nervous system infections	PK data in pediatric patients with ventriculoperitoneal shunts showed variable cerebrospinal fluid (CSF) concentrations; therapeutic concentrations were not consistently achieved or maintained in the CSF Use of linezolid for the empiric treatment of pediatric patients with central nervous system infections is not recommended Additional information on efficacy in pediatric patients with infectious vancomycin-resistant Enterococcus faecium	Labeling	B	-	-	-	Pfizer	11/2/2005	FALSE'
MESH:D019955	12/5/2005	zyvox	linezolid	Central nervous system infections	PK data in pediatric patients with ventriculoperitoneal shunts showed variable cerebrospinal fluid (CSF) concentrations; therapeutic concentrations were not consistently achieved or maintained in the CSF Use of linezolid for the empiric treatment of pediatric patients with central nervous system infections is not recommended Additional information on efficacy in pediatric patients with infectious vancomycin-resistant Enterococcus faecium	Labeling	B	-	-	-	Pfizer	11/2/2005	FALSE'
MESH:D019955	6/4/2006	daytrana	methylphenidate	ADHD	Summary is pending	Labeling	-	P	-	-	Shire	-	FALSE'
MESH:D019955	12/14/2009	daytrana	methylphenidate	Postmarketing safety study	Information added to Warnings and Adverse Reactions on skin reactions observed in a postmarketing dermal study in pediatric patients	Labeling	-	P	-	-	Shire	-	FALSE'
MESH:D019955	06/29/2010	daytrana	methylphenidate	ADHD	Expanded pediatric indication to include adolescent patients ages13-17 years The most commonly reported adverse reactions in a trial in patients 13-17 years included appetite decreased, nausea, insomnia, weight decreased, dizziness, abdominal pain, and anorexia. The majority of patients had erythema at the application site Information on PK parameters, Adverse Event profile and clinical studies	Labeling	-	P	-	-	Shire	-	FALSE'