PedAM

Pediatric Disease Annotations & Medicines


	compartment syndrome

Disease ID	596
Disease	compartment syndrome
Definition	Conditions in which increased pressure within a limited space compromises the BLOOD CIRCULATION and function of tissue within that space. Some of the causes of increased pressure are TRAUMA, tight dressings, HEMORRHAGE, and exercise. Sequelae include nerve compression (NERVE COMPRESSION SYNDROMES); PARALYSIS; and ISCHEMIC CONTRACTURE.
Synonym	compartment syndrome (disorder) compartment syndrome nos compartment syndrome, nos compartment syndrome, unspecified compartment syndromes compartment syndromes [disease/finding] compartmental syndrome compartmental syndrome, nos compartmental syndromes syndrome, compartment syndromes, compartment
DOID	DOID:682
UMLS	C0009492
MeSH	D003161
SNOMED-CT	SNOMEDCT_US_2016_09_01:111245009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:47) C0001339 \| acute pancreatitis \| 7 C0035078 \| renal failure \| 6 C0030305 \| pancreatitis \| 6 C0022116 \| ischemia \| 5 C0022660 \| acute renal failure \| 3 C0020538 \| hypertension \| 3 C0025160 \| megacolon \| 3 C0162871 \| abdominal aortic aneurysm \| 2 C1704275 \| pyomyositis \| 2 C0023473 \| chronic myeloid leukemia \| 2 C0012739 \| disseminated intravascular coagulation \| 2 C0037054 \| sickle cell trait \| 2 C0021400 \| influenza \| 2 C0007642 \| cellulitis \| 2 C0025162 \| toxic megacolon \| 2 C0856761 \| budd-chiari syndrome \| 1 C0007286 \| carpal tunnel syndrome \| 1 C2267227 \| bulimia nervosa \| 1 C0085113 \| neurofibromatosis \| 1 C0035302 \| retinal artery occlusion \| 1 C0006370 \| bulimia \| 1 C0011849 \| diabetes mellitus \| 1 C0270810 \| peroneal nerve palsy \| 1 C0015645 \| fasciitis \| 1 C0040053 \| thrombus \| 1 C0343084 \| capillary leak syndrome \| 1 C0011847 \| diabetes \| 1 C0034065 \| pulmonary embolism \| 1 C0343084 \| systemic capillary leak syndrome \| 1 C0020676 \| hypothyroidism \| 1 C0023895 \| liver disease \| 1 C0456909 \| blindness \| 1 C0025303 \| meningococcal disease \| 1 C0019069 \| factor viii deficiency \| 1 C0027726 \| nephrotic syndrome \| 1 C0039614 \| tetanus \| 1 C0238124 \| necrotizing fasciitis \| 1 C0002766 \| analgesia \| 1 C0006663 \| calcinosis \| 1 C0003486 \| aortic aneurysm \| 1 C0007688 \| central retinal artery occlusion \| 1 C0040053 \| thrombosis \| 1 C0020757 \| ichthyosis \| 1 C0038353 \| gastric dilatation \| 1 C0017924 \| mcardle disease \| 1 C0017924 \| mcardle's disease \| 1 C0442874 \| neuropathy \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) HPX \| 3263 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:98) 27102 \| EIF2AK1 \| DISEASES 8086 \| AAAS \| DISEASES 2999 \| GZMH \| DISEASES 5020 \| OXT \| DISEASES 51285 \| RASL12 \| DISEASES 55907 \| CMAS \| DISEASES 662 \| BNIP1 \| DISEASES 56920 \| SEMA3G \| DISEASES 3488 \| IGFBP5 \| DISEASES 3070 \| HELLS \| DISEASES 5589 \| PRKCSH \| DISEASES 1401 \| CRP \| DISEASES 8170 \| SLC14A2 \| DISEASES 29969 \| MDFIC \| DISEASES 3569 \| IL6 \| DISEASES 4836 \| NMT1 \| DISEASES 51201 \| ZDHHC2 \| DISEASES 3674 \| ITGA2B \| DISEASES 6521 \| SLC4A1 \| DISEASES 6558 \| SLC12A2 \| DISEASES 25939 \| SAMHD1 \| DISEASES 3553 \| IL1B \| DISEASES 25759 \| SHC2 \| DISEASES 80321 \| CEP70 \| DISEASES 10058 \| ABCB6 \| DISEASES 1998 \| ELF2 \| DISEASES 5286 \| PIK3C2A \| DISEASES 3487 \| IGFBP4 \| DISEASES 150094 \| SIK1 \| DISEASES 2169 \| FABP2 \| DISEASES 4715 \| NDUFB9 \| DISEASES 3934 \| LCN2 \| DISEASES 4851 \| NOTCH1 \| DISEASES 138151 \| NACC2 \| DISEASES 60496 \| AASDHPPT \| DISEASES 351 \| APP \| DISEASES 6529 \| SLC6A1 \| DISEASES 5739 \| PTGIR \| DISEASES 114757 \| CYGB \| DISEASES 126820 \| WDR63 \| DISEASES 213 \| ALB \| DISEASES 23305 \| ACSL6 \| DISEASES 23588 \| KLHDC2 \| DISEASES 90678 \| LRSAM1 \| DISEASES 140738 \| TMEM37 \| DISEASES 51181 \| DCXR \| DISEASES 2147 \| F2 \| DISEASES 5340 \| PLG \| DISEASES 137735 \| ABRA \| DISEASES 55588 \| MED29 \| DISEASES 203859 \| ANO5 \| DISEASES 23621 \| BACE1 \| DISEASES 5034 \| P4HB \| DISEASES 9021 \| SOCS3 \| DISEASES 71 \| ACTG1 \| DISEASES 2152 \| F3 \| DISEASES 219541 \| MED19 \| DISEASES 132884 \| EVC2 \| DISEASES 5170 \| PDPK1 \| DISEASES 331 \| XIAP \| DISEASES 51703 \| ACSL5 \| DISEASES 7068 \| THRB \| DISEASES 4151 \| MB \| DISEASES 2157 \| F8 \| DISEASES 4720 \| NDUFS2 \| DISEASES 6281 \| S100A10 \| DISEASES 8277 \| TKTL1 \| DISEASES 282991 \| BLOC1S2 \| DISEASES 4952 \| OCRL \| DISEASES 5730 \| PTGDS \| DISEASES 23413 \| NCS1 \| DISEASES 5303 \| PIN4 \| DISEASES 7099 \| TLR4 \| DISEASES 2155 \| F7 \| DISEASES 9350 \| CER1 \| DISEASES 51109 \| RDH11 \| DISEASES 1497 \| CTNS \| DISEASES 26278 \| SACS \| DISEASES 10411 \| RAPGEF3 \| DISEASES 5799 \| PTPRN2 \| DISEASES 57222 \| ERGIC1 \| DISEASES 55291 \| PPP6R3 \| DISEASES 64115 \| C10orf54 \| DISEASES 1365 \| CLDN3 \| DISEASES 9701 \| PPP6R2 \| DISEASES 3652 \| IPP \| DISEASES 7702 \| ZNF143 \| DISEASES 2160 \| F11 \| DISEASES 8291 \| DYSF \| DISEASES 6916 \| TBXAS1 \| DISEASES 7124 \| TNF \| DISEASES 9278 \| ZBTB22 \| DISEASES 54900 \| LAX1 \| DISEASES 2972 \| BRF1 \| DISEASES 820 \| CAMP \| DISEASES 11201 \| POLI \| DISEASES 102723508 \| KANTR \| DISEASES 100128252 \| ZNF667-AS1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	596
Disease	compartment syndrome
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:42) HP:0003201 \| Rhabdomyolysis \| 8 HP:0012531 \| Pain \| 7 HP:0001735 \| Acute pancreatitis \| 5 HP:0001733 \| Pancreatic inflammation \| 4 HP:0000083 \| Renal insufficiency \| 3 HP:0000822 \| Hypertension \| 3 HP:0001919 \| Acute renal failure \| 3 HP:0000969 \| Dropsy \| 3 HP:0002251 \| Hirschsprung megacolon \| 3 HP:0100758 \| Gangrene \| 2 HP:0005506 \| Chronic myeloid leukemia \| 2 HP:0030005 \| Capillary leak \| 2 HP:0001959 \| Polydipsia \| 2 HP:0003418 \| Back pain \| 2 HP:0000572 \| Visual loss \| 2 HP:0100658 \| Bacterial infection of skin \| 2 HP:0004953 \| Abdominal aortic aneurysm \| 2 HP:0005521 \| Disseminated intravascular coagulation \| 1 HP:0000821 \| Underactive thyroid \| 1 HP:0003419 \| Low back pain \| 1 HP:0008080 \| Medially deviated halluces \| 1 HP:0000832 \| Primary hypothyroidism \| 1 HP:0001399 \| Liver failure \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0002153 \| Elevated serum potassium levels \| 1 HP:0002094 \| Dyspnea \| 1 HP:0000618 \| Blindness \| 1 HP:0002204 \| Pulmonary embolism \| 1 HP:0000980 \| Pallor \| 1 HP:0002617 \| Aneurysmal dilatation \| 1 HP:0000100 \| Nephrosis \| 1 HP:0011854 \| Hemoperitoneum \| 1 HP:0003073 \| Hypoalbuminaemia \| 1 HP:0010783 \| Erythema \| 1 HP:0100806 \| Sepsis \| 1 HP:0004942 \| Aortic aneurysm \| 1 HP:0001067 \| Neurofibromas \| 1 HP:0004448 \| Fulminant hepatic failure \| 1 HP:0008064 \| Ichthyosis \| 1 HP:0004936 \| Blood clot in vein \| 1 HP:0003761 \| Calcinosis \| 1 HP:0100739 \| Binge and purge \| 1

Disease ID	596
Disease	compartment syndrome
Manually Symptom	UMLS \| Name(Total Manually Symptoms:3) C2598155 \| pain C0343084 \| systemic capillary leak syndrome C0270810 \| peroneal nerve palsy
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:3) C0030193 \| pain \| 7 C0343084 \| systemic capillary leak syndrome \| 1 C0270810 \| peroneal nerve palsy \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:5)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0009492	acetylcysteine	D000111	616-91-1	compartment syndromes	MESH:D003161	therapeutic	20309660
C0009492	clozapine	D003024	5786-21-0	compartment syndromes	MESH:D003161	marker/mechanism	19697595
C0009492	creatine	D003401	57-00-1	compartment syndromes	MESH:D003161	marker/mechanism	10764196
C0009492	linezolid	D000069349	-	compartment syndromes	MESH:D003161	therapeutic	18606349
C0009492	vancomycin	D014640	1404-90-6	compartment syndromes	MESH:D003161	therapeutic	18606349

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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