PedAM

Pediatric Disease Annotations & Medicines


	cleft soft palate

Disease ID	877
Disease	cleft soft palate
Definition	Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency. [HPO:curators]
Synonym	cleft muscular palate cleft of soft palate cleft of soft palate (disorder) cleft of soft palate only cleft soft palate nos cleft soft palate nos (disorder) cleft soft palate, central cleft velum soft cleft palate
Orphanet	ORPHANET:99772
OMIM	OMIM:119570
DOID	DOID:674
ICD10	ICD10CM:Q35.3
UMLS	C0432098
SNOMED-CT	SNOMEDCT_US_2016_09_01:253997002
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) GRHL3 \| 57822 \| ORPHANET
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:20) 27121 \| DKK4 \| DISEASES 3199 \| HOXA2 \| DISEASES 4488 \| MSX2 \| DISEASES 23314 \| SATB2 \| DISEASES 2052 \| EPHX1 \| DISEASES 9317 \| PTER \| DISEASES 4330 \| MN1 \| DISEASES 6899 \| TBX1 \| DISEASES 23760 \| PITPNB \| DISEASES 554 \| AVPR2 \| DISEASES 4771 \| NF2 \| DISEASES 6890 \| TAP1 \| DISEASES 7048 \| TGFBR2 \| DISEASES 1312 \| COMT \| DISEASES 50945 \| TBX22 \| DISEASES 113452 \| TMEM54 \| DISEASES 22943 \| DKK1 \| DISEASES 1285 \| COL4A3 \| DISEASES 23331 \| TTC28 \| DISEASES 64324 \| NSD1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	877
Disease	cleft soft palate
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:1) HP:0000185 \| Cleft velum
Text Mined Phenotype	(Waiting for update.)

Disease ID	877
Disease	cleft soft palate
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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