PedAM

Pediatric Disease Annotations & Medicines


	chronic pain

Disease ID	696
Disease	chronic pain
Definition	pain which has persisted over a long period of time; also use NTs for specific types of pain if appropriate.
Synonym	chronic pain (finding) chronic pain [disease/finding] chronic pains pain, chronic pains, chronic
UMLS	C0150055
MeSH	D059350
SNOMED-CT	SNOMEDCT_US_2016_09_01:82423001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:127) C0011570 \| depression \| 54 C0003467 \| anxiety \| 29 C0029408 \| osteoarthritis \| 21 C0016053 \| fibromyalgia \| 16 C0002766 \| analgesia \| 11 C0037317 \| sleep disturbance \| 7 C0003864 \| arthritis \| 7 C0442874 \| neuropathy \| 7 C0041696 \| major depressive disorder \| 4 C0020619 \| hypogonadism \| 4 C0009806 \| constipation \| 4 C0019294 \| inguinal hernia \| 3 C0014175 \| endometriosis \| 3 C0002895 \| sickle cell disease \| 3 C0033953 \| sexual dysfunction \| 3 C0007286 \| carpal tunnel syndrome \| 3 C0026769 \| multiple sclerosis \| 3 C0028754 \| obesity \| 3 C0003873 \| rheumatoid arthritis \| 3 C0030567 \| parkinson's disease \| 3 C0031117 \| peripheral neuropathy \| 3 C0149931 \| migraine \| 2 C0041696 \| major depression \| 2 C0006012 \| borderline personality disorder \| 2 C0039494 \| temporomandibular disorder \| 2 C0022408 \| joint disease \| 2 C0851578 \| sleep disorders \| 2 C0016053 \| fibromyalgia syndrome \| 2 C0029456 \| osteoporosis \| 2 C0003864 \| inflammatory arthritis \| 2 C0042870 \| vitamin d deficiency \| 2 C0085413 \| autosomal dominant polycystic kidney \| 2 C0042870 \| vitamin d defic \| 2 C0019348 \| herpes simplex \| 2 C0235974 \| pancreatic cancer \| 2 C0271680 \| diabetic polyneuropathy \| 2 C0003469 \| anxiety disorder \| 2 C0085413 \| autosomal dominant polycystic kidney disease \| 2 C0031212 \| personality disorders \| 2 C0022679 \| cystic kidney \| 2 C0039494 \| temporomandibular disorders \| 2 C0015674 \| chronic fatigue syndrome \| 2 C0002020 \| alexithymia \| 2 C0040997 \| trigeminal neuralgia \| 2 C0158266 \| disc degeneration \| 2 C0003469 \| anxiety disorders \| 2 C0011882 \| diabetic neuropathy \| 2 C0040188 \| tic disorders \| 2 C0037650 \| somatoform disorders \| 1 C0524851 \| neurodegenerative disease \| 1 C0010674 \| cystic fibrosis \| 1 C0013502 \| hydatid cyst \| 1 C0028768 \| obsessive-compulsive disorder \| 1 C0010692 \| cystitis \| 1 C0852949 \| arterial disease \| 1 C0242429 \| sore throat \| 1 C0017653 \| glomus tumor \| 1 C1145670 \| respiratory failure \| 1 C0028817 \| ochronosis \| 1 C0020538 \| hypertension \| 1 C0037650 \| somatoform disorder \| 1 C0021390 \| inflammatory bowel disease \| 1 C0004936 \| mental disorders \| 1 C0022104 \| irritable bowel \| 1 C0029095 \| opioid abuse \| 1 C0948265 \| metabolic syndrome \| 1 C0003090 \| ankylosis \| 1 C0022658 \| renal disease \| 1 C0022408 \| arthropathy \| 1 C0497327 \| dementia \| 1 C0029401 \| paget's disease \| 1 C0024586 \| serotonin syndrome \| 1 C0149521 \| chronic pancreatitis \| 1 C1956089 \| osteophyte \| 1 C0037317 \| sleep disturbances \| 1 C0022104 \| irritable bowel syndrome \| 1 C0018801 \| heart failure \| 1 C0158266 \| intervertebral disc degeneration \| 1 C0027765 \| neurological disorder \| 1 C0025289 \| meningitis \| 1 C0011334 \| dental caries \| 1 C0004096 \| asthma \| 1 C0024198 \| lyme borreliosis \| 1 C0022116 \| ischemia \| 1 C0017178 \| gastrointestinal disorders \| 1 C0854776 \| unresectable pancreatic cancer \| 1 C0019555 \| developmental dysplasia of the hip \| 1 C0019158 \| hepatitis \| 1 C0476089 \| endometrial ca \| 1 C0029401 \| paget's disease of bone \| 1 C0023895 \| liver disease \| 1 C0458219 \| complex regional pain syndrome \| 1 C1704436 \| peripheral arterial disease \| 1 C0854778 \| resectable pancreatic cancer \| 1 C0019069 \| haemophilia \| 1 C0007789 \| cerebral palsy \| 1 C0679466 \| cognitive deficits \| 1 C0022408 \| arthrosis \| 1 C0008055 \| chikungunya fever \| 1 C0011847 \| diabetes \| 1 C0743332 \| focal dystonia \| 1 C0520680 \| central sleep apnea \| 1 C0271623 \| secondary hypogonadism \| 1 C0038436 \| post-traumatic stress disorder \| 1 C0021831 \| bowel disease \| 1 C0022821 \| kyphosis \| 1 C0017178 \| gastrointestinal disorder \| 1 C1510472 \| drug dependence \| 1 C0282488 \| interstitial cystitis \| 1 C0018916 \| hemangiomas \| 1 C0019196 \| hepatitis c \| 1 C0037944 \| spinal stenosis \| 1 C0035258 \| restless legs \| 1 C0006142 \| breast cancer \| 1 C0524851 \| neurodegenerative diseases \| 1 C0014544 \| epilepsy \| 1 C0476089 \| endometrial carcinoma \| 1 C0037315 \| sleep apnea \| 1 C0003708 \| arachnoiditis \| 1 C0001622 \| hypercortisolism \| 1 C0022661 \| end-stage renal disease \| 1 C0021843 \| intestinal obstruction \| 1 C0158266 \| degenerative disc disease \| 1 C0037933 \| spinal disorder \| 1 C0011334 \| caries \| 1 C0029408 \| degenerative joint disease \| 1 C0035258 \| restless legs syndrome \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) SCN9A \| 6335 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	696
Disease	chronic pain
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:87) HP:0012531 \| Pain \| 146 HP:0000716 \| Depression \| 54 HP:0000739 \| Anxiety \| 29 HP:0002758 \| Osteoarthritis \| 21 HP:0003418 \| Back pain \| 11 HP:0100785 \| Insomnia \| 11 HP:0100790 \| Hernia \| 8 HP:0002315 \| Headaches \| 7 HP:0001369 \| Arthritis \| 7 HP:0012378 \| Fatigue \| 7 HP:0000708 \| Behavioral problems \| 7 HP:0002360 \| Sleep disturbance \| 7 HP:0012533 \| Allodynia \| 7 HP:0003419 \| Low back pain \| 6 HP:0100543 \| Cognitive deficits \| 6 HP:0002019 \| Dyschezia \| 4 HP:0005086 \| Knee osteoarthritis \| 4 HP:0012075 \| Personality disorder \| 4 HP:0000135 \| Hypogonadism \| 4 HP:0001249 \| Mental retardation \| 3 HP:0009830 \| Peripheral neuritis \| 3 HP:0030127 \| Endometriosis \| 3 HP:0002354 \| Memory loss \| 3 HP:0008843 \| Hip osteoarthritis \| 3 HP:0000023 \| Inguinal hernia \| 3 HP:0001370 \| Rheumatoid arthritis \| 3 HP:0001513 \| Obesity \| 3 HP:0002664 \| Neoplasia \| 3 HP:0012076 \| Borderline personality disorder \| 2 HP:0000113 \| Polycystic kidney dysplasia \| 2 HP:0000939 \| Osteoporosis \| 2 HP:0100661 \| Trigeminal neuralgia \| 2 HP:0001382 \| Hyperextensible joints \| 2 HP:0001250 \| Seizures \| 2 HP:0002076 \| Migraine headaches \| 2 HP:0012534 \| Dysesthesia \| 2 HP:0002894 \| Neoplasia of the pancreas \| 2 HP:0100512 \| Vitamin D deficiency \| 2 HP:0002015 \| Swallowing difficulty \| 2 HP:0100033 \| Tic disorder \| 2 HP:0001631 \| Atria septal defect \| 1 HP:0002829 \| Arthralgias \| 1 HP:0002500 \| Leukoaraiosis \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0000670 \| Dental caries \| 1 HP:0004610 \| Narrow lumbar spinal canal \| 1 HP:0001751 \| Vestibular dysfunction \| 1 HP:0006280 \| Chronic pancreas inflammation \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0002933 \| Ventral hernia \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0003040 \| Arthropathy \| 1 HP:0012444 \| Brain wasting \| 1 HP:0100699 \| Scarring \| 1 HP:0002878 \| Respiratory failure \| 1 HP:0012114 \| Endometrial carcinoma \| 1 HP:0000722 \| Obsessive compulsive disorder \| 1 HP:0002527 \| Falls \| 1 HP:0100021 \| Cerebral palsy \| 1 HP:0001635 \| Congestive heart failure \| 1 HP:0010885 \| Aseptic necrosis \| 1 HP:0003416 \| Spinal canal stenosis \| 1 HP:0030731 \| Carcinoma \| 1 HP:0004950 \| Peripheral artery disease \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0001287 \| Meningitis \| 1 HP:0000822 \| Hypertension \| 1 HP:0002808 \| Gibbus deformity \| 1 HP:0002099 \| Asthma \| 1 HP:0008419 \| Degeneration of intervertebral disks \| 1 HP:0002180 \| Neurodegeneration \| 1 HP:0001379 \| Degenerative joint disease \| 1 HP:0010535 \| Sleep apnea \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0012432 \| Chronic fatigue \| 1 HP:0001824 \| Weight loss \| 1 HP:0010536 \| Central sleep apnoea \| 1 HP:0000726 \| Dementia \| 1 HP:0011868 \| Sciatica \| 1 HP:0005214 \| Bowel obstruction \| 1 HP:0030764 \| Ochronosis \| 1 HP:0012452 \| Restless legs \| 1 HP:0003401 \| Paresthesia \| 1 HP:0006824 \| Cranial nerve palsy \| 1 HP:0200136 \| Oral-pharyngeal dysphagia \| 1 HP:0004373 \| Focal dystonia \| 1 HP:0001578 \| Hypercortisolism \| 1

Disease ID	696
Disease	chronic pain
Manually Symptom	UMLS \| Name(Total Manually Symptoms:50) C2364108 \| stigma C2364074 \| drug abuse C2364072 \| depression C2364051 \| fatigue C2364045 \| activity intolerance C1963237 \| insomnia C1963138 \| hypertension C1963087 \| constipation C1963064 \| anxiety C1842981 \| neuroticism C1839611 \| n syndrome C1660219 \| analgesia C1568272 \| tendinopathy C1546654 \| granuloma C1269683 \| major depressive disorder C1269683 \| major depression C1135120 \| breakthrough pain C0947622 \| gallstones C0853946 \| exacerbation of pain C0851578 \| sleep problem C0851578 \| sleep disturbances C0851578 \| sleep disorders C0751188 \| postdural puncture headache C0700361 \| distress C0700201 \| sleep disturbance C0679466 \| cognitive deficits C0575031 \| cervical facet joint pain C0549622 \| sexual dysfunction C0522224 \| palsy C0520680 \| central sleep apnea C0278139 \| moderate pain C0269106 \| endosalpingiosis C0262471 \| ent problem C0262405 \| brain dysfunction C0240735 \| personality changes C0233470 \| constricted affect C0086439 \| reduced activity C0086132 \| emotional depression C0086132 \| depressive symptoms C0038436 \| posttraumatic stress disorder C0038436 \| post-traumatic stress disorder C0038220 \| status epilepticus C0037650 \| somatoform disorders C0031212 \| personality disorders C0029095 \| opioid abuse C0020604 \| hypochondriasis C0004936 \| mental disorders C0003469 \| anxiety disorders C0002962 \| angina pectoris C0002020 \| alexithymia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:30) C0011570 \| depression \| 54 C0003467 \| anxiety \| 29 C0231303 \| distress \| 19 C0002766 \| analgesia \| 11 C0917801 \| insomnia \| 11 C0015672 \| fatigue \| 7 C0086132 \| depressive symptoms \| 6 C0037317 \| sleep disturbance \| 6 C1839611 \| n syndrome \| 4 C0041696 \| major depressive disorder \| 4 C0009806 \| constipation \| 4 C0033953 \| sexual dysfunction \| 3 C0041696 \| major depression \| 2 C0031212 \| personality disorders \| 2 C0002020 \| alexithymia \| 2 C0003469 \| anxiety disorders \| 2 C0700201 \| sleep problem \| 2 C0851578 \| sleep disorders \| 2 C1135120 \| breakthrough pain \| 1 C0037317 \| sleep disturbances \| 1 C0853946 \| exacerbation of pain \| 1 C0020538 \| hypertension \| 1 C0037650 \| somatoform disorders \| 1 C0013146 \| drug abuse \| 1 C0004936 \| mental disorders \| 1 C0038436 \| post-traumatic stress disorder \| 1 C0679466 \| cognitive deficits \| 1 C0029095 \| opioid abuse \| 1 C0520680 \| central sleep apnea \| 1 C0522224 \| palsy \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:9)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1045642	23803057	4988	OPRM1	umls:C0150055	BeFree	Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual variability regarding pain sensitivity, opioid usage, tolerance and dependence and incidence of adverse effects in patients with chronic pain.	0.001357209	2015	ABCB1	7	87509329	A	T,G
rs1045642	23803057	5243	ABCB1	umls:C0150055	BeFree	Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual variability regarding pain sensitivity, opioid usage, tolerance and dependence and incidence of adverse effects in patients with chronic pain.	0.000542884	2015	ABCB1	7	87509329	A	T,G
rs1799971	23803057	4988	OPRM1	umls:C0150055	BeFree	Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual variability regarding pain sensitivity, opioid usage, tolerance and dependence and incidence of adverse effects in patients with chronic pain.	0.001357209	2015	OPRM1	6	154039662	A	G
rs1799971	17000822	4988	OPRM1	umls:C0150055	BeFree	A genetic association study of the functional A118G polymorphism of the human mu-opioid receptor gene in patients with acute and chronic pain.	0.001357209	2006	OPRM1	6	154039662	A	G
rs1799971	23803057	5243	ABCB1	umls:C0150055	BeFree	Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual variability regarding pain sensitivity, opioid usage, tolerance and dependence and incidence of adverse effects in patients with chronic pain.	0.000542884	2015	OPRM1	6	154039662	A	G
rs386602118	21049025	1312	COMT	umls:C0150055	BeFree	However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated by the presence of chronic pain.	0.002171535	2010	NA	NA	NA	NA	NA
rs4680	22722321	1312	COMT	umls:C0150055	BeFree	The meta-analyses showed that fibromyalgia or chronic widespread pain is the only type of chronic pain that could be associated with the COMT single nucleotide polymorphism rs4680 (Val158Met).	0.002171535	2012	COMT;MIR4761	22	19963748	G	A
rs4680	21049025	1312	COMT	umls:C0150055	BeFree	However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated by the presence of chronic pain.	0.002171535	2010	COMT;MIR4761	22	19963748	G	A
rs4680	23773341	1312	COMT	umls:C0150055	BeFree	This study highlights the importance of COMT rs4680 in influencing the clinical response to drugs used for chronic pain, including opioid analgesics and triptans.	0.002171535	2013	COMT;MIR4761	22	19963748	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0150055	pregabalin	D000069583	-	chronic pain	MESH:D059350	therapeutic	19664204

FDA approved drug and dosage information(Total Drugs:3)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D059350	lyrica	pregabalin	25MG	CAPSULE;ORAL	Prescription	None	Yes	No
MESH:D059350	lyrica	pregabalin	25MG	CAPSULE; ORAL	Prescription	None	No	No
MESH:D059350	lyrica	pregabalin	25MG	CAPSULE; ORAL	Prescription	None	No	No

FDA labeling changes(Total Drugs:3)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D059350	12/22/2016	lyrica	pregabalin	Fibromyalgia	Safety and efficacy in pediatric patients have not been established. A 15-week, placebo-controlled trial was conducted with 107 pediatric patients with fibromyalgia, ages 12 through 17 years . The primary efficacy endpoint of change from baseline to Week 15 in mean pain intensity showed numerically greater improvement for the pregabalin-treated patients compared to placebo-treated patients, but did not reach statistical significance. The most frequently observed adverse reactions in the clinical trial included dizziness, nausea, headache, weight increased, and fatigue. The overall safety profile in adolescents was similar to that observed in adults with fibromyalgia. Postmarketing study.	Labeling	-	P	-	-	PF Prism CV	-	FALSE
MESH:D059350	12/22/2016	lyrica	pregabalin	Fibromyalgia	Safety and efficacy in pediatric patients have not been established. A 15-week, placebo-controlled trial was conducted with 107 pediatric patients with fibromyalgia, ages 12 through 17 years . The primary efficacy endpoint of change from baseline to Week 15 in mean pain intensity showed numerically greater improvement for the pregabalin-treated patients compared to placebo-treated patients, but did not reach statistical significance. The most frequently observed adverse reactions in the clinical trial included dizziness, nausea, headache, weight increased, and fatigue. The overall safety profile in adolescents was similar to that observed in adults with fibromyalgia. Postmarketing study.	Labeling	-	P	-	-	PF Prism CV	-	FALSE
MESH:D059350	12/22/2016	lyrica	pregabalin	Fibromyalgia	Safety and efficacy in pediatric patients have not been established. A 15-week, placebo-controlled trial was conducted with 107 pediatric patients with fibromyalgia, ages 12 through 17 years . The primary efficacy endpoint of change from baseline to Week 15 in mean pain intensity showed numerically greater improvement for the pregabalin-treated patients compared to placebo-treated patients, but did not reach statistical significance. The most frequently observed adverse reactions in the clinical trial included dizziness, nausea, headache, weight increased, and fatigue. The overall safety profile in adolescents was similar to that observed in adults with fibromyalgia. Postmarketing study.	Labeling	-	P	-	-	PF Prism CV	-	FALSE

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