PedAM

Pediatric Disease Annotations & Medicines


	chronic kidney failure

Disease ID	503
Disease	chronic kidney failure
Definition	The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Synonym	chronic renal disease chronic renal failure chronic renal failure (crf) chronic renal failure nos chronic renal failure syndrome chronic renal failure syndrome (disorder) chronic renal failure syndrome, nos crf - chronic renal failure disease, end-stage kidney disease, end-stage renal end stage chronc renal failure end stage chronic renal failure end stage kidney dis end stage kidney disease end stage renal dis end stage renal disease end stage renal disease (disorder) end stage renal disease (esrd) end stage renal failure end stage renal failure (disorder) end-stage kidney disease end-stage renal disease end-stage renal failure escrf - end stage chronic renal failure esrd esrd (end stage renal disease) esrd - end stage renal disease esrf - end stage renal failure failure, renal -chronic kidney disease, end-stage kidney failure chronic kidney failure, chronic kidney failure, chronic [disease/finding] kidney, failure, chronic renal dis end stage renal disease, end stage renal disease, end-stage renal failure (chronic) renal failure - chronic renal failure chronic renal failure chronic renal failure chronic uremia renal failure, chronic renal failure, end stage renal failure, end-stage
DOID	DOID:784 DOID:783
ICD10	ICD10CM:N18.6
UMLS	C0022661
MeSH	D007676
SNOMED-CT	SNOMEDCT_US_2016_09_01:90688005;SNOMEDCT_US_2016_09_01:46177005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:24) C0011847 \| diabetes \| 2 C0007222 \| cardiovascular disease \| 2 C0028754 \| obesity \| 2 C0002871 \| anemia \| 2 C0042373 \| vascular disease \| 2 C0020502 \| hyperparathyroidism \| 1 C0032285 \| pneumonia \| 1 C0003873 \| rheumatoid arthritis \| 1 C0010481 \| cushing's syndrome \| 1 C0014038 \| encephalitis \| 1 C0020598 \| hypoglycaemia \| 1 C0028756 \| morbid obesity \| 1 C0020437 \| hypercalcemia \| 1 C0026764 \| multiple myeloma \| 1 C0022658 \| kidney disease \| 1 C0085681 \| hyperphosphataemia \| 1 C0011849 \| diabetes mellitus \| 1 C0027709 \| nephrocalcinosis \| 1 C0003864 \| arthritis \| 1 C0005940 \| bone disease \| 1 C0740394 \| hyperuricemia \| 1 C0026764 \| myeloma \| 1 C0015624 \| fanconi syndrome \| 1 C0020626 \| hypoparathyroidism \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:45) TNF \| 7124 \| CTD_human IL6 \| 3569 \| CTD_human TGFB1 \| 7040 \| CTD_human ABCA1 \| 19 \| CTD_human CD68 \| 968 \| CTD_human ADIPOQ \| 9370 \| CTD_human CRP \| 1401 \| CTD_human HMOX1 \| 3162 \| CTD_human CCL2 \| 6347 \| CTD_human RELA \| 5970 \| CTD_human PPARA \| 5465 \| CTD_human PTGS2 \| 5743 \| CTD_human MYH9 \| 4627 \| CTD_human ABCG1 \| 9619 \| CTD_human GUCA2B \| 2981 \| CTD_human ALB \| 213 \| CTD_human CAT \| 847 \| CTD_human ACE \| 1636 \| CTD_human CYBA \| 1535 \| CTD_human CYBB \| 1536 \| CTD_human MSR1 \| 4481 \| CTD_human EPO \| 2056 \| CTD_human IGF1 \| 3479 \| CTD_human MLXIPL \| 51085 \| CTD_human PTGS1 \| 5742 \| CTD_human SERPINE1 \| 5054 \| CTD_human RETN \| 56729 \| CTD_human NGF \| 4803 \| CTD_human CYP2B6 \| 1555 \| CTD_human NCF1 \| 653361 \| CTD_human CYP2C19 \| 1557 \| CTD_human ACAT1 \| 38 \| CTD_human NFKB1 \| 4790 \| CTD_human HMGCR \| 3156 \| CTD_human FASN \| 2194 \| CTD_human HAMP \| 57817 \| CTD_human FABP1 \| 2168 \| CTD_human SCARB1 \| 949 \| CTD_human HBEGF \| 1839 \| CTD_human CPT1A \| 1374 \| CTD_human PAX2 \| 5076 \| CTD_human ADIPOR1 \| 51094 \| CTD_human SREBF2 \| 6721 \| CTD_human SREBF1 \| 6720 \| CTD_human NOX4 \| 50507 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:178) 4846 \| NOS3 \| infer 7421 \| VDR \| infer 1636 \| ACE \| infer 5820 \| PVT1 \| infer 19 \| ABCA1 \| infer 5243 \| ABCB1 \| infer 6833 \| ABCC8 \| infer 6296 \| ACSM3 \| infer 9370 \| ADIPOQ \| infer 153 \| ADRB1 \| infer 154 \| ADRB2 \| infer 155 \| ADRB3 \| infer 177 \| AGER \| infer 183 \| AGT \| infer 185 \| AGTR1 \| infer 186 \| AGTR2 \| infer 11216 \| AKAP10 \| infer 217 \| ALDH2 \| infer 240 \| ALOX5 \| infer 308 \| ANXA5 \| infer 1173 \| AP2M1 \| infer 335 \| APOA1 \| infer 116519 \| APOA5 \| infer 345 \| APOC3 \| infer 348 \| APOE \| infer 350 \| APOH \| infer 80832 \| APOL4 \| infer 590 \| BCHE \| infer 624 \| BDKRB2 \| infer 641 \| BLM \| infer 11132 \| CAPN10 \| infer 6356 \| CCL11 \| infer 6352 \| CCL5 \| infer 595 \| CCND1 \| infer 729230 \| CCR2 \| infer 1234 \| CCR5 \| infer 929 \| CD14 \| infer 948 \| CD36 \| infer 1071 \| CETP \| infer 4261 \| CIITA \| infer 1278 \| COL1A2 \| infer 1281 \| COL3A1 \| infer 1312 \| COMT \| infer 1361 \| CPB2 \| infer 1401 \| CRP \| infer 1511 \| CTSG \| infer 1524 \| CX3CR1 \| infer 58191 \| CXCL16 \| infer 1535 \| CYBA \| infer 1585 \| CYP11B2 \| infer 1558 \| CYP2C8 \| infer 1573 \| CYP2J2 \| infer 1577 \| CYP3A5 \| infer 1628 \| DBP \| infer 1653 \| DDX1 \| infer 1906 \| EDN1 \| infer 1909 \| EDNRA \| infer 2006 \| ELN \| infer 2022 \| ENG \| infer 5167 \| ENPP1 \| infer 2053 \| EPHX2 \| infer 2099 \| ESR1 \| infer 2161 \| F12 \| infer 2152 \| F3 \| infer 2155 \| F7 \| infer 2169 \| FABP2 \| infer 2200 \| FBN1 \| infer 2244 \| FGB \| infer 2642 \| GCGR \| infer 2645 \| GCK \| infer 2729 \| GCLC \| infer 2730 \| GCLM \| infer 2701 \| GJA4 \| infer 127534 \| GJB4 \| infer 2784 \| GNB3 \| infer 2811 \| GP1BA \| infer 51206 \| GP6 \| infer 2876 \| GPX1 \| infer 2997 \| GYS1 \| infer 3105 \| HLA-A \| infer 3106 \| HLA-B \| infer 3123 \| HLA-DRB1 \| infer 3162 \| HMOX1 \| infer 6927 \| HNF1A \| infer 3172 \| HNF4A \| infer 3312 \| HSPA8 \| infer 3375 \| IAPP \| infer 3383 \| ICAM1 \| infer 3482 \| IGF2R \| infer 3586 \| IL10 \| infer 3553 \| IL1B \| infer 3558 \| IL2 \| infer 3565 \| IL4 \| infer 3569 \| IL6 \| infer 3615 \| IMPDH2 \| infer 3630 \| INS \| infer 3643 \| INSR \| infer 3667 \| IRS1 \| infer 3673 \| ITGA2 \| infer 3689 \| ITGB2 \| infer 3767 \| KCNJ11 \| infer 79932 \| KIAA0319L \| infer 9365 \| KL \| infer 3949 \| LDLR \| infer 3952 \| LEP \| infer 3957 \| LGALS2 \| infer 3990 \| LIPC \| infer 9388 \| LIPG \| infer 4000 \| LMNA \| infer 4023 \| LPL \| infer 4049 \| LTA \| infer 4256 \| MGP \| infer 4312 \| MMP1 \| infer 4321 \| MMP12 \| infer 4313 \| MMP2 \| infer 4314 \| MMP3 \| infer 4318 \| MMP9 \| infer 4353 \| MPO \| infer 744 \| MPPED2 \| infer 4524 \| MTHFR \| infer 7827 \| NPHS2 \| infer 4878 \| NPPA \| infer 2908 \| NR3C1 \| infer 4973 \| OLR1 \| infer 64805 \| P2RY12 \| infer 5078 \| PAX4 \| infer 5105 \| PCK1 \| infer 255738 \| PCSK9 \| infer 5144 \| PDE4D \| infer 3651 \| PDX1 \| infer 5175 \| PECAM1 \| infer 5295 \| PIK3R1 \| infer 7941 \| PLA2G7 \| infer 5327 \| PLAT \| infer 5333 \| PLCD1 \| infer 5338 \| PLD2 \| infer 5444 \| PON1 \| infer 5445 \| PON2 \| infer 5467 \| PPARD \| infer 5468 \| PPARG \| infer 10891 \| PPARGC1A \| infer 5506 \| PPP1R3A \| infer 8858 \| PROZ \| infer 5730 \| PTGDS \| infer 5740 \| PTGIS \| infer 5743 \| PTGS2 \| infer 5770 \| PTPN1 \| infer 26191 \| PTPN22 \| infer 56729 \| RETN \| infer 6098 \| ROS1 \| infer 6401 \| SELE \| infer 6402 \| SELL \| infer 6403 \| SELP \| infer 12 \| SERPINA3 \| infer 5054 \| SERPINE1 \| infer 116369 \| SLC26A8 \| infer 6690 \| SPINK1 \| infer 6720 \| SREBF1 \| infer 6804 \| STX1A \| infer 7040 \| TGFB1 \| infer 7048 \| TGFBR2 \| infer 7056 \| THBD \| infer 7058 \| THBS2 \| infer 7060 \| THBS4 \| infer 7066 \| THPO \| infer 7099 \| TLR4 \| infer 7124 \| TNF \| infer 7292 \| TNFSF4 \| infer 7350 \| UCP1 \| infer 7351 \| UCP2 \| infer 7352 \| UCP3 \| infer 7369 \| UMOD \| infer 10911 \| UTS2 \| infer 7422 \| VEGFA \| infer 118 \| ADD1 \| infer 846 \| CASR \| infer 3117 \| HLA-DQA1 \| infer 3119 \| HLA-DQB1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:497) 100505854 \| APTR \| DISEASES 101928243 \| DARS-AS1 \| DISEASES 920 \| CD4 \| DISEASES 64132 \| XYLT2 \| DISEASES 7132 \| TNFRSF1A \| DISEASES 6793 \| STK10 \| DISEASES 350 \| APOH \| DISEASES 25837 \| RAB26 \| DISEASES 23411 \| SIRT1 \| DISEASES 4282 \| MIF \| DISEASES 3162 \| HMOX1 \| DISEASES 49 \| ACR \| DISEASES 4627 \| MYH9 \| DISEASES 7380 \| UPK3A \| DISEASES 623 \| BDKRB1 \| DISEASES 7076 \| TIMP1 \| DISEASES 2717 \| GLA \| DISEASES 479 \| ATP12A \| DISEASES 54 \| ACP5 \| DISEASES 4313 \| MMP2 \| DISEASES 221191 \| PRSS54 \| DISEASES 7249 \| TSC2 \| DISEASES 4210 \| MEFV \| DISEASES 51285 \| RASL12 \| DISEASES 1666 \| DECR1 \| DISEASES 5327 \| PLAT \| DISEASES 54623 \| PAF1 \| DISEASES 56729 \| RETN \| DISEASES 2091 \| FBL \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 2057 \| EPOR \| DISEASES 11045 \| UPK1A \| DISEASES 57817 \| HAMP \| DISEASES 7392 \| USF2 \| DISEASES 5444 \| PON1 \| DISEASES 3082 \| HGF \| DISEASES 10135 \| NAMPT \| DISEASES 5054 \| SERPINE1 \| DISEASES 727 \| C5 \| DISEASES 4353 \| MPO \| DISEASES 6347 \| CCL2 \| DISEASES 6928 \| HNF1B \| DISEASES 1277 \| COL1A1 \| DISEASES 3381 \| IBSP \| DISEASES 3558 \| IL2 \| DISEASES 345 \| APOC3 \| DISEASES 969 \| CD69 \| DISEASES 4256 \| MGP \| DISEASES 3458 \| IFNG \| DISEASES 57122 \| NUP107 \| DISEASES 2784 \| GNB3 \| DISEASES 2690 \| GHR \| DISEASES 3565 \| IL4 \| DISEASES 2908 \| NR3C1 \| DISEASES 338 \| APOB \| DISEASES 3485 \| IGFBP2 \| DISEASES 3488 \| IGFBP5 \| DISEASES 5657 \| PRTN3 \| DISEASES 335 \| APOA1 \| DISEASES 7276 \| TTR \| DISEASES 5311 \| PKD2 \| DISEASES 8074 \| FGF23 \| DISEASES 91754 \| NEK9 \| DISEASES 5507 \| PPP1R3C \| DISEASES 8600 \| TNFSF11 \| DISEASES 847 \| CAT \| DISEASES 4852 \| NPY \| DISEASES 11328 \| FKBP9 \| DISEASES 6615 \| SNAI1 \| DISEASES 5184 \| PEPD \| DISEASES 2806 \| GOT2 \| DISEASES 718 \| C3 \| DISEASES 6945 \| MLX \| DISEASES 2678 \| GGT1 \| DISEASES 2952 \| GSTT1 \| DISEASES 968 \| CD68 \| DISEASES 1215 \| CMA1 \| DISEASES 5908 \| RAP1B \| DISEASES 3630 \| INS \| DISEASES 60625 \| DHX35 \| DISEASES 5589 \| PRKCSH \| DISEASES 348 \| APOE \| DISEASES 341 \| APOC1 \| DISEASES 59272 \| ACE2 \| DISEASES 81 \| ACTN4 \| DISEASES 2056 \| EPO \| DISEASES 10343 \| PKDREJ \| DISEASES 8431 \| NR0B2 \| DISEASES 3958 \| LGALS3 \| DISEASES 10462 \| CLEC10A \| DISEASES 182 \| JAG1 \| DISEASES 1401 \| CRP \| DISEASES 325 \| APCS \| DISEASES 64328 \| XPO4 \| DISEASES 284904 \| SEC14L4 \| DISEASES 5375 \| PMP2 \| DISEASES 81494 \| CFHR5 \| DISEASES 10599 \| SLCO1B1 \| DISEASES 9662 \| CEP135 \| DISEASES 23595 \| ORC3 \| DISEASES 2799 \| GNS \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 4856 \| NOV \| DISEASES 27283 \| TINAG \| DISEASES 440279 \| UNC13C \| DISEASES 7057 \| THBS1 \| DISEASES 51187 \| RSL24D1 \| DISEASES 51196 \| PLCE1 \| DISEASES 9360 \| PPIG \| DISEASES 3417 \| IDH1 \| DISEASES 4069 \| LYZ \| DISEASES 55746 \| NUP133 \| DISEASES 7450 \| VWF \| DISEASES 1535 \| CYBA \| DISEASES 999 \| CDH1 \| DISEASES 5939 \| RBMS2 \| DISEASES 23531 \| MMD \| DISEASES 4087 \| SMAD2 \| DISEASES 5310 \| PKD1 \| DISEASES 3674 \| ITGA2B \| DISEASES 27130 \| INVS \| DISEASES 10558 \| SPTLC1 \| DISEASES 495 \| ATP4A \| DISEASES 25939 \| SAMHD1 \| DISEASES 10133 \| OPTN \| DISEASES 23523 \| CABIN1 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 23476 \| BRD4 \| DISEASES 55717 \| WDR11 \| DISEASES 23024 \| PDZRN3 \| DISEASES 6403 \| SELP \| DISEASES 4036 \| LRP2 \| DISEASES 3791 \| KDR \| DISEASES 3931 \| LCAT \| DISEASES 941 \| CD80 \| DISEASES 2247 \| FGF2 \| DISEASES 5443 \| POMC \| DISEASES 10686 \| CLDN16 \| DISEASES 118 \| ADD1 \| DISEASES 3383 \| ICAM1 \| DISEASES 3827 \| KNG1 \| DISEASES 1950 \| EGF \| DISEASES 22937 \| SCAP \| DISEASES 51608 \| GET4 \| DISEASES 11070 \| TMEM115 \| DISEASES 6527 \| SLC5A4 \| DISEASES 8128 \| ST8SIA2 \| DISEASES 284086 \| NEK8 \| DISEASES 3487 \| IGFBP4 \| DISEASES 207 \| AKT1 \| DISEASES 113091 \| PTH2 \| DISEASES 57530 \| CGN \| DISEASES 54856 \| GON4L \| DISEASES 5972 \| REN \| DISEASES 132001 \| TAMM41 \| DISEASES 185 \| AGTR1 \| DISEASES 3484 \| IGFBP1 \| DISEASES 3934 \| LCN2 \| DISEASES 133 \| ADM \| DISEASES 7356 \| SCGB1A1 \| DISEASES 3606 \| IL18 \| DISEASES 166785 \| MMAA \| DISEASES 5741 \| PTH \| DISEASES 1420 \| CRYGC \| DISEASES 22925 \| PLA2R1 \| DISEASES 8526 \| DGKE \| DISEASES 9056 \| SLC7A7 \| DISEASES 231 \| AKR1B1 \| DISEASES 2040 \| STOM \| DISEASES 7547 \| ZIC3 \| DISEASES 6750 \| SST \| DISEASES 5468 \| PPARG \| DISEASES 3156 \| HMGCR \| DISEASES 79178 \| THTPA \| DISEASES 4643 \| MYO1E \| DISEASES 26060 \| APPL1 \| DISEASES 22808 \| MRAS \| DISEASES 909 \| CD1A \| DISEASES 4681 \| NBL1 \| DISEASES 63916 \| ELMO2 \| DISEASES 1636 \| ACE \| DISEASES 374739 \| TEPP \| DISEASES 2220 \| FCN2 \| DISEASES 1234 \| CCR5 \| DISEASES 3046 \| HBE1 \| DISEASES 114757 \| CYGB \| DISEASES 6352 \| CCL5 \| DISEASES 7412 \| VCAM1 \| DISEASES 2215 \| FCGR3B \| DISEASES 27306 \| HPGDS \| DISEASES 2168 \| FABP1 \| DISEASES 213 \| ALB \| DISEASES 5196 \| PF4 \| DISEASES 57619 \| SHROOM3 \| DISEASES 149461 \| CLDN19 \| DISEASES 308 \| ANXA5 \| DISEASES 9607 \| CARTPT \| DISEASES 1437 \| CSF2 \| DISEASES 4982 \| TNFRSF11B \| DISEASES 4846 \| NOS3 \| DISEASES 203286 \| ANKS6 \| DISEASES 55172 \| DNAAF2 \| DISEASES 282974 \| STK32C \| DISEASES 1014 \| CDH16 \| DISEASES 6553 \| SLC9A5 \| DISEASES 84516 \| DCTN5 \| DISEASES 26585 \| GREM1 \| DISEASES 90678 \| LRSAM1 \| DISEASES 50964 \| SOST \| DISEASES 4054 \| LTBP3 \| DISEASES 5617 \| PRL \| DISEASES 189 \| AGXT \| DISEASES 3479 \| IGF1 \| DISEASES 170575 \| GIMAP1 \| DISEASES 257019 \| FRMD3 \| DISEASES 929 \| CD14 \| DISEASES 124401 \| ANKS3 \| DISEASES 25928 \| SOSTDC1 \| DISEASES 8862 \| APLN \| DISEASES 7369 \| UMOD \| DISEASES 10067 \| SCAMP3 \| DISEASES 624 \| BDKRB2 \| DISEASES 54205 \| CYCS \| DISEASES 2147 \| F2 \| DISEASES 660 \| BMX \| DISEASES 5340 \| PLG \| DISEASES 23529 \| CLCF1 \| DISEASES 254263 \| CNIH2 \| DISEASES 947 \| CD34 \| DISEASES 836 \| CASP3 \| DISEASES 358 \| AQP1 \| DISEASES 2944 \| GSTM1 \| DISEASES 9657 \| IQCB1 \| DISEASES 7351 \| UCP2 \| DISEASES 9844 \| ELMO1 \| DISEASES 5319 \| PLA2G1B \| DISEASES 3952 \| LEP \| DISEASES 4867 \| NPHP1 \| DISEASES 9380 \| GRHPR \| DISEASES 4179 \| CD46 \| DISEASES 7030 \| TFE3 \| DISEASES 3078 \| CFHR1 \| DISEASES 1191 \| CLU \| DISEASES 25839 \| COG4 \| DISEASES 3291 \| HSD11B2 \| DISEASES 147912 \| SIX5 \| DISEASES 8542 \| APOL1 \| DISEASES 9377 \| COX5A \| DISEASES 64388 \| GREM2 \| DISEASES 10409 \| BASP1 \| DISEASES 9370 \| ADIPOQ \| DISEASES 23765 \| IL17RA \| DISEASES 3321 \| IGSF3 \| DISEASES 4018 \| LPA \| DISEASES 23539 \| SLC16A8 \| DISEASES 5345 \| SERPINF2 \| DISEASES 3039 \| HBA1 \| DISEASES 8100 \| IFT88 \| DISEASES 2 \| A2M \| DISEASES 1453 \| CSNK1D \| DISEASES 55748 \| CNDP2 \| DISEASES 9622 \| KLK4 \| DISEASES 3052 \| HCCS \| DISEASES 6524 \| SLC5A2 \| DISEASES 352999 \| C6orf58 \| DISEASES 9735 \| KNTC1 \| DISEASES 3855 \| KRT7 \| DISEASES 375287 \| RBM43 \| DISEASES 7490 \| WT1 \| DISEASES 2520 \| GAST \| DISEASES 6401 \| SELE \| DISEASES 2621 \| GAS6 \| DISEASES 3418 \| IDH2 \| DISEASES 1287 \| COL4A5 \| DISEASES 1675 \| CFD \| DISEASES 55328 \| RNLS \| DISEASES 4088 \| SMAD3 \| DISEASES 5587 \| PRKD1 \| DISEASES 11247 \| NXPH4 \| DISEASES 51004 \| COQ6 \| DISEASES 342184 \| FMN1 \| DISEASES 55742 \| PARVA \| DISEASES 2152 \| F3 \| DISEASES 10881 \| ACTL7A \| DISEASES 51738 \| GHRL \| DISEASES 283 \| ANG \| DISEASES 8710 \| SERPINB7 \| DISEASES 114548 \| NLRP3 \| DISEASES 2042 \| EPHA3 \| DISEASES 1576 \| CYP3A4 \| DISEASES 554 \| AVPR2 \| DISEASES 27031 \| NPHP3 \| DISEASES 3266 \| ERAS \| DISEASES 80320 \| SP6 \| DISEASES 7225 \| TRPC6 \| DISEASES 32 \| ACACB \| DISEASES 4306 \| NR3C2 \| DISEASES 23480 \| SEC61G \| DISEASES 51094 \| ADIPOR1 \| DISEASES 7137 \| TNNI3 \| DISEASES 6187 \| RPS2 \| DISEASES 92399 \| MRRF \| DISEASES 8481 \| OFD1 \| DISEASES 51077 \| FCF1 \| DISEASES 1499 \| CTNNB1 \| DISEASES 26762 \| HAVCR1 \| DISEASES 119391 \| GSTO2 \| DISEASES 57524 \| CASKIN1 \| DISEASES 2335 \| FN1 \| DISEASES 25847 \| ANAPC13 \| DISEASES 94086 \| HSPB9 \| DISEASES 6666 \| SOX12 \| DISEASES 4010 \| LMX1B \| DISEASES 2204 \| FCAR \| DISEASES 3240 \| HP \| DISEASES 84502 \| JPH4 \| DISEASES 3476 \| IGBP1 \| DISEASES 3899 \| AFF3 \| DISEASES 5789 \| PTPRD \| DISEASES 6288 \| SAA1 \| DISEASES 5625 \| PRODH \| DISEASES 2695 \| GIP \| DISEASES 23556 \| PIGN \| DISEASES 55784 \| MCTP2 \| DISEASES 84735 \| CNDP1 \| DISEASES 55243 \| KIRREL \| DISEASES 23607 \| CD2AP \| DISEASES 8936 \| WASF1 \| DISEASES 4151 \| MB \| DISEASES 3123 \| HLA-DRB1 \| DISEASES 79947 \| DHDDS \| DISEASES 7037 \| TFRC \| DISEASES 84063 \| KIRREL2 \| DISEASES 149371 \| EXOC8 \| DISEASES 4311 \| MME \| DISEASES 1803 \| DPP4 \| DISEASES 5167 \| ENPP1 \| DISEASES 2475 \| MTOR \| DISEASES 10724 \| MGEA5 \| DISEASES 56670 \| SUCNR1 \| DISEASES 23038 \| WDTC1 \| DISEASES 9860 \| LRIG2 \| DISEASES 10806 \| SDCCAG8 \| DISEASES 183 \| AGT \| DISEASES 22796 \| COG2 \| DISEASES 28514 \| DLL1 \| DISEASES 1378 \| CR1 \| DISEASES 25778 \| DSTYK \| DISEASES 7139 \| TNNT2 \| DISEASES 10878 \| CFHR3 \| DISEASES 3075 \| CFH \| DISEASES 7827 \| NPHS2 \| DISEASES 462 \| SERPINC1 \| DISEASES 2214 \| FCGR3A \| DISEASES 1490 \| CTGF \| DISEASES 911 \| CD1C \| DISEASES 632 \| BGLAP \| DISEASES 4582 \| MUC1 \| DISEASES 8416 \| ANXA9 \| DISEASES 11231 \| SEC63 \| DISEASES 57107 \| PDSS2 \| DISEASES 100506164 \| HSFX1 \| DISEASES 60495 \| HPSE2 \| DISEASES 959 \| CD40LG \| DISEASES 4952 \| OCRL \| DISEASES 27022 \| FOXD3 \| DISEASES 5314 \| PKHD1 \| DISEASES 860 \| RUNX2 \| DISEASES 5950 \| RBP4 \| DISEASES 5730 \| PTGDS \| DISEASES 186 \| AGTR2 \| DISEASES 11093 \| ADAMTS13 \| DISEASES 7422 \| VEGFA \| DISEASES 2889 \| RAPGEF1 \| DISEASES 1288 \| COL4A6 \| DISEASES 64405 \| CDH22 \| DISEASES 4318 \| MMP9 \| DISEASES 25844 \| YIPF3 \| DISEASES 1907 \| EDN2 \| DISEASES 310 \| ANXA7 \| DISEASES 90550 \| MCU \| DISEASES 2740 \| GLP1R \| DISEASES 286204 \| CRB2 \| DISEASES 27293 \| SMPDL3B \| DISEASES 4153 \| MBL2 \| DISEASES 1896 \| EDA \| DISEASES 10880 \| ACTL7B \| DISEASES 249 \| ALPL \| DISEASES 1650 \| DDOST \| DISEASES 6392 \| SDHD \| DISEASES 2159 \| F10 \| DISEASES 9923 \| ZBTB40 \| DISEASES 3055 \| HCK \| DISEASES 10673 \| TNFSF13B \| DISEASES 11330 \| CTRC \| DISEASES 1184 \| CLCN5 \| DISEASES 50943 \| FOXP3 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 4879 \| NPPB \| DISEASES 4878 \| NPPA \| DISEASES 4524 \| MTHFR \| DISEASES 3105 \| HLA-A \| DISEASES 1471 \| CST3 \| DISEASES 7056 \| THBD \| DISEASES 8718 \| TNFRSF25 \| DISEASES 83715 \| ESPN \| DISEASES 8029 \| CUBN \| DISEASES 261734 \| NPHP4 \| DISEASES 768 \| CA9 \| DISEASES 10159 \| ATP6AP2 \| DISEASES 51473 \| DCDC2 \| DISEASES 10497 \| UNC13B \| DISEASES 3980 \| LIG3 \| DISEASES 6354 \| CCL7 \| DISEASES 4868 \| NPHS1 \| DISEASES 375790 \| AGRN \| DISEASES 1906 \| EDN1 \| DISEASES 390598 \| SKOR1 \| DISEASES 9365 \| KL \| DISEASES 551 \| AVP \| DISEASES 150084 \| IGSF5 \| DISEASES 10531 \| PITRM1 \| DISEASES 6557 \| SLC12A1 \| DISEASES 3486 \| IGFBP3 \| DISEASES 1497 \| CTNS \| DISEASES 23600 \| AMACR \| DISEASES 7436 \| VLDLR \| DISEASES 64423 \| INF2 \| DISEASES 2591 \| GALNT3 \| DISEASES 51559 \| NT5DC3 \| DISEASES 27032 \| ATP2C1 \| DISEASES 5973 \| RENBP \| DISEASES 11346 \| SYNPO \| DISEASES 3426 \| CFI \| DISEASES 6696 \| SPP1 \| DISEASES 655 \| BMP7 \| DISEASES 1285 \| COL4A3 \| DISEASES 7702 \| ZNF143 \| DISEASES 1286 \| COL4A4 \| DISEASES 4780 \| NFE2L2 \| DISEASES 346562 \| GNAT3 \| DISEASES 340990 \| OTOG \| DISEASES 9814 \| SFI1 \| DISEASES 729920 \| ISPD \| DISEASES 728441 \| GGT2 \| DISEASES 7018 \| TF \| DISEASES 114781 \| BTBD9 \| DISEASES 151242 \| PPP1R1C \| DISEASES 4648 \| MYO7B \| DISEASES 2641 \| GCG \| DISEASES 522 \| ATP5J \| DISEASES 10640 \| EXOC5 \| DISEASES 91147 \| TMEM67 \| DISEASES 3481 \| IGF2 \| DISEASES 23005 \| MAPKBP1 \| DISEASES 197 \| AHSG \| DISEASES 85443 \| DCLK3 \| DISEASES 10163 \| WASF2 \| DISEASES 5076 \| PAX2 \| DISEASES 720 \| C4A \| DISEASES 57545 \| CC2D2A \| DISEASES 7124 \| TNF \| DISEASES 24147 \| FJX1 \| DISEASES 2821 \| GPI \| DISEASES 221981 \| THSD7A \| DISEASES 23098 \| SARM1 \| DISEASES 2876 \| GPX1 \| DISEASES 9734 \| HDAC9 \| DISEASES 3586 \| IL10 \| DISEASES 721 \| C4B \| DISEASES 629 \| CFB \| DISEASES 6092 \| ROBO2 \| DISEASES 374308 \| PTCHD3 \| DISEASES 846 \| CASR \| DISEASES 2649 \| NR6A1 \| DISEASES 2638 \| GC \| DISEASES 51428 \| DDX41 \| DISEASES 100130086 \| HSFX2 \| DISEASES 4914 \| NTRK1 \| DISEASES 7164 \| TPD52L1 \| DISEASES 8615 \| USO1 \| DISEASES 3684 \| ITGAM \| DISEASES 7421 \| VDR \| DISEASES 8972 \| MGAM \| DISEASES 80184 \| CEP290 \| DISEASES 51303 \| FKBP11 \| DISEASES 56963 \| RGMA \| DISEASES 567 \| B2M \| DISEASES 820 \| CAMP \| DISEASES 344 \| APOC2 \| DISEASES 7138 \| TNNT1 \| DISEASES 246734 \| NPCDR1 \| DISEASES 5820 \| PVT1 \| DISEASES 100128252 \| ZNF667-AS1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	503
Disease	chronic kidney failure
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:19) HP:0001903 \| Anemia \| 2 HP:0001513 \| Obesity \| 2 HP:0000819 \| Diabetes mellitus \| 1 HP:0004943 \| Accelerated atherosclerosis \| 1 HP:0003072 \| Hypercalcemia \| 1 HP:0000829 \| Hypoparathyroidism \| 1 HP:0002090 \| Pneumonia \| 1 HP:0001941 \| acidemia \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0001994 \| 'de toni-fanconi-debre' syndrome \| 1 HP:0001369 \| Arthritis \| 1 HP:0012592 \| Albuminuria \| 1 HP:0006775 \| Multiple myeloma \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0000121 \| Nephrocalcinosis \| 1 HP:0001943 \| Hypoglycemia \| 1 HP:0002383 \| Encephalitis \| 1 HP:0000843 \| Hyperparathyroidism \| 1 HP:0002149 \| Hyperuricemia \| 1

Disease ID	503
Disease	chronic kidney failure
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:5) C0002871 \| anemia \| 2 C0007222 \| cardiovascular disease \| 2 C0242339 \| dyslipidemia \| 1 C0025517 \| metabolic disorders \| 1 C0020502 \| hyperparathyroidism \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:152)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10137082	23147652	26246	OR2L2	umls:C0022661	BeFree	Genotyping analysis demonstrated that 2 SNPs among 13 were significantly associated with ESRD after adjusting for age and sex, which were shown by IL17E rs10137082 (odds ratio (OR) 1.48 in codominant 1, OR 1.54 in dominant, OR 1.47 in log-additive) and IL17RA rs4819554 (OR 1.46 in codominant 1, OR 1.79 in codominant 2, OR 1.54 in dominant, OR 1.39 in log-additive).	0.000271442	2012	IL25	14	23370824	C	T
rs10404257	22965004	8542	APOL1	umls:C0022661	BeFree	SNPs were tested for interaction with markers in the APOL1 gene, previously associated with non-DM ESRD in AAs, and rs10404257 was modestly associated (p = 0.0261, additive model).	0.009967404	2012	ACTN4	19	38645846	G	A
rs1042713	20484896	154	ADRB2	umls:C0022661	BeFree	We extended our findings to an independent case/control sample of Black hypertensive ESRD, in which we found that variant Gly16Arg that tagged the GFR slope-determining ADRB2 haplotype also conferred risk for the ESRD trait in Blacks.	0.002638474	2010	ADRB2	5	148826877	G	A
rs11089788	21245129	4627	MYH9	umls:C0022661	BeFree	Based on a large Chinese IgAN cohort, we found an association between rs11089788 and prognosis of IgAN, adding to the mounting evidence of MYH9 as an important gene in IgAN to ESRD.	0.133887143	2011	MYH9	22	36355056	C	A
rs11614913	24978643	406941	MIR149	umls:C0022661	BeFree	The aim of this study was to investigate the impact of MIR146A C>G (rs2910164), MIR149 T>C (rs2292832), MIR196A2 T>C (rs11614913), and MIR499A A>G (rs3746444) single nucleotide polymorphisms (SNPs) among end-stage renal disease (ESRD) and acute allograft rejection (AR) cases.	0.000271442	2015	MIR196A2	12	53991815	C	T
rs11614913	24978643	406973	MIR196A2	umls:C0022661	BeFree	The aim of this study was to investigate the impact of MIR146A C>G (rs2910164), MIR149 T>C (rs2292832), MIR196A2 T>C (rs11614913), and MIR499A A>G (rs3746444) single nucleotide polymorphisms (SNPs) among end-stage renal disease (ESRD) and acute allograft rejection (AR) cases.	0.000271442	2015	MIR196A2	12	53991815	C	T
rs11614913	24978643	574501	MIR499A	umls:C0022661	BeFree	The aim of this study was to investigate the impact of MIR146A C>G (rs2910164), MIR149 T>C (rs2292832), MIR196A2 T>C (rs11614913), and MIR499A A>G (rs3746444) single nucleotide polymorphisms (SNPs) among end-stage renal disease (ESRD) and acute allograft rejection (AR) cases.	0.000542884	2015	MIR196A2	12	53991815	C	T
rs11614913	24978643	406938	MIR146A	umls:C0022661	BeFree	The aim of this study was to investigate the impact of MIR146A C>G (rs2910164), MIR149 T>C (rs2292832), MIR196A2 T>C (rs11614913), and MIR499A A>G (rs3746444) single nucleotide polymorphisms (SNPs) among end-stage renal disease (ESRD) and acute allograft rejection (AR) cases.	0.000271442	2015	MIR196A2	12	53991815	C	T
rs12137135	24871321	102724428	LOC102724428	umls:C0022661	BeFree	Five genetic loci (WNT4/ZBTB40-rs12137135, RGMA/MCTP2-rs17709344, MAPRE1P2-rs1670754, SEMA6D/SLC24A5-rs12917114 and SIK1-rs2838302) were associated with ESRD in the FinnDiane study.	0.000271442	2014	NA	1	22348728	A	C,G
rs12137135	24871321	80031	SEMA6D	umls:C0022661	BeFree	rs12917114 near SEMA6D was associated with ESRD in the replication cohorts under the genotypic model (p < 0.05), and rs12137135 upstream of WNT4 was associated with ESRD in Steno.	0.000271442	2014	NA	1	22348728	A	C,G
rs12137135	24871321	283652	SLC24A5	umls:C0022661	BeFree	Five genetic loci (WNT4/ZBTB40-rs12137135, RGMA/MCTP2-rs17709344, MAPRE1P2-rs1670754, SEMA6D/SLC24A5-rs12917114 and SIK1-rs2838302) were associated with ESRD in the FinnDiane study.	0.000271442	2014	NA	1	22348728	A	C,G
rs12137135	24871321	54361	WNT4	umls:C0022661	BeFree	rs12917114 near SEMA6D was associated with ESRD in the replication cohorts under the genotypic model (p < 0.05), and rs12137135 upstream of WNT4 was associated with ESRD in Steno.	0.000271442	2014	NA	1	22348728	A	C,G
rs121913059	19633317	3075	CFH	umls:C0022661	BeFree	We report a case of successful single kidney allograft transplantation in a patient with a CFH gene mutation (R1210C), who had end-stage renal failure after three flares of aHUS treated with plasma exchange.	0.009077134	2009	CFH	1	196747245	C	T
rs12437854	23028342	56963	RGMA	umls:C0022661	BeFree	After additional genotyping of 41 top ranked SNPs representing 24 independent signals in 5,873 individuals, combined meta-analysis revealed association of two SNPs with ESRD: rs7583877 in the AFF3 gene (P = 1.2 × 10(-8)) and an intergenic SNP on chromosome 15q26 between the genes RGMA and MCTP2, rs12437854 (P = 2.0 × 10(-9)).	0.000542884	2012	NA	15	93598604	T	G
rs12437854	23028342	3899	AFF3	umls:C0022661	BeFree	After additional genotyping of 41 top ranked SNPs representing 24 independent signals in 5,873 individuals, combined meta-analysis revealed association of two SNPs with ESRD: rs7583877 in the AFF3 gene (P = 1.2 × 10(-8)) and an intergenic SNP on chromosome 15q26 between the genes RGMA and MCTP2, rs12437854 (P = 2.0 × 10(-9)).	0.000271442	2012	NA	15	93598604	T	G
rs12437854	23028342	55784	MCTP2	umls:C0022661	BeFree	After additional genotyping of 41 top ranked SNPs representing 24 independent signals in 5,873 individuals, combined meta-analysis revealed association of two SNPs with ESRD: rs7583877 in the AFF3 gene (P = 1.2 × 10(-8)) and an intergenic SNP on chromosome 15q26 between the genes RGMA and MCTP2, rs12437854 (P = 2.0 × 10(-9)).	0.000542884	2012	NA	15	93598604	T	G
rs12917114	24871321	283652	SLC24A5	umls:C0022661	BeFree	Five genetic loci (WNT4/ZBTB40-rs12137135, RGMA/MCTP2-rs17709344, MAPRE1P2-rs1670754, SEMA6D/SLC24A5-rs12917114 and SIK1-rs2838302) were associated with ESRD in the FinnDiane study.	0.000271442	2014	NA	15	47852953	C	T
rs12917114	24871321	54361	WNT4	umls:C0022661	BeFree	rs12917114 near SEMA6D was associated with ESRD in the replication cohorts under the genotypic model (p < 0.05), and rs12137135 upstream of WNT4 was associated with ESRD in Steno.	0.000271442	2014	NA	15	47852953	C	T
rs12917114	24871321	80031	SEMA6D	umls:C0022661	BeFree	rs12917114 near SEMA6D was associated with ESRD in the replication cohorts under the genotypic model (p < 0.05), and rs12137135 upstream of WNT4 was associated with ESRD in Steno.	0.000271442	2014	NA	15	47852953	C	T
rs12917114	24871321	102724428	LOC102724428	umls:C0022661	BeFree	Five genetic loci (WNT4/ZBTB40-rs12137135, RGMA/MCTP2-rs17709344, MAPRE1P2-rs1670754, SEMA6D/SLC24A5-rs12917114 and SIK1-rs2838302) were associated with ESRD in the FinnDiane study.	0.000271442	2014	NA	15	47852953	C	T
rs12917707	19430482	7369	UMOD	umls:C0022661	GAD	[Multiple loci associated with indices of renal function and chronic kidney disease.]	0.006710102	2009	UMOD	16	20356368	G	T
rs13447075	17881614	391191	OR2AK2	umls:C0022661	BeFree	Markers rs13447075 (odds ratio [OR] 1.47 [95% CI 1.14-1.89] per copy of A allele; P = 0.003) and rs2648862 (2.66 [1.19-5.92] per copy of C allele; P = 0.008) were strongly associated with ESRD in analyses adjusting for age(2), age(3), duration of diabetes, and smoking status.	0.000271442	2007	NA	NA	NA	NA	NA
rs1516792	12837270	3552	IL1A	umls:C0022661	BeFree	Eleven SNPs show some evidence of association with ESRD, with the strongest associations in two IL1A variants, one SNP, rs1516792-3, in intron 5 (p=0.0015) and a 4-bp insertion/deletion within the 3'UTR, rs16347-2 (p=0.0024), among African Americans with non-T2DM-associated ESRD.	0.006362715	2003	IL1A	2	112778356	G	A
rs1570360	19060482	7422	VEGFA	umls:C0022661	BeFree	The aim of the present study was to assess the influence of the -2578 C/A and the -1154 G/A polymorphisms in the regulatory region of the VEGF gene upon the progression of ADPKD toward end-stage renal disease (ESRD).	0.014992773	2008	VEGFA	6	43770093	A	G
rs1570360	21080079	7422	VEGFA	umls:C0022661	BeFree	Hence, the -1154 G>A polymorphism (rs1570360) and two haplotypes (CGTC and CATC) of VEGF appear to be associated with hypertensive nephropathy in Hispanic patients who developed end-stage renal disease requiring kidney transplant.	0.014992773	2011	VEGFA	6	43770093	A	G
rs161740	22721967	2056	EPO	umls:C0022661	BeFree	We found little evidence for the association of the EPO promoter polymorphism, rs161740, with the combined phenotype of proliferative retinopathy and end-stage renal disease in U.K.-R.O.I.	0.128153188	2012	CHD1	5	98869326	C	A,T
rs1617640	21092038	2056	EPO	umls:C0022661	BeFree	Recently, it was demonstrated that the T allele of SNP rs1617640 in the promoter of the erythropoetin (EPO) gene is significantly associated with proliferative diabetic retinopathy (PDR) and end-stage renal disease (ESRD) due to increased EPO expression.	0.128153188	2010	EPO	7	100719675	C	A
rs1617640	18458324	2056	EPO	umls:C0022661	BeFree	These results suggest that rs1617640 in the EPO promoter is significantly associated with PDR and ESRD.	0.128153188	2008	EPO	7	100719675	C	A
rs16347	12837270	3552	IL1A	umls:C0022661	BeFree	Eleven SNPs show some evidence of association with ESRD, with the strongest associations in two IL1A variants, one SNP, rs1516792-3, in intron 5 (p=0.0015) and a 4-bp insertion/deletion within the 3'UTR, rs16347-2 (p=0.0024), among African Americans with non-T2DM-associated ESRD.	0.006362715	2003	IL1A	2	112774142	-	TGAA
rs1670754	24871321	102724428	LOC102724428	umls:C0022661	BeFree	Five genetic loci (WNT4/ZBTB40-rs12137135, RGMA/MCTP2-rs17709344, MAPRE1P2-rs1670754, SEMA6D/SLC24A5-rs12917114 and SIK1-rs2838302) were associated with ESRD in the FinnDiane study.	0.000271442	2014	NA	4	32263375	G	A
rs1670754	24871321	283652	SLC24A5	umls:C0022661	BeFree	Five genetic loci (WNT4/ZBTB40-rs12137135, RGMA/MCTP2-rs17709344, MAPRE1P2-rs1670754, SEMA6D/SLC24A5-rs12917114 and SIK1-rs2838302) were associated with ESRD in the FinnDiane study.	0.000271442	2014	NA	4	32263375	G	A
rs1695	18413200	4846	NOS3	umls:C0022661	BeFree	In south Indian (SI) subjects there was significant allelic and genotypic association of the wild-type allele in SOD2 (Ala9Val; P=.002 and P=.013, respectively), UCP1 (-112 T>G, P=.012 and P=.009; Ala64Thr, P=.015 and P=.004), NOS3 (Glu298Asp, P=.002 and P=.009) and GSTP1 (Ile105Val, P=.003 and P=.004) genes with development of CRI.	0.13744224	2009	GSTP1	11	67585218	A	G
rs1695	24423050	2952	GSTT1	umls:C0022661	BeFree	We examined association between GSTM1 and GSTT1 deletion polymorphisms as well as SNPs in GSTA1/rs3957357 and GSTP1/rs1695 genes with overall and cause-specific cardiovascular mortality in ESRD patients.	0.008544182	2013	GSTP1	11	67585218	A	G
rs1695	18413200	7350	UCP1	umls:C0022661	BeFree	In south Indian (SI) subjects there was significant allelic and genotypic association of the wild-type allele in SOD2 (Ala9Val; P=.002 and P=.013, respectively), UCP1 (-112 T>G, P=.012 and P=.009; Ala64Thr, P=.015 and P=.004), NOS3 (Glu298Asp, P=.002 and P=.009) and GSTP1 (Ile105Val, P=.003 and P=.004) genes with development of CRI.	0.002638474	2009	GSTP1	11	67585218	A	G
rs1695	18413200	2950	GSTP1	umls:C0022661	BeFree	In south Indian (SI) subjects there was significant allelic and genotypic association of the wild-type allele in SOD2 (Ala9Val; P=.002 and P=.013, respectively), UCP1 (-112 T>G, P=.012 and P=.009; Ala64Thr, P=.015 and P=.004), NOS3 (Glu298Asp, P=.002 and P=.009) and GSTP1 (Ile105Val, P=.003 and P=.004) genes with development of CRI.	0.005634266	2009	GSTP1	11	67585218	A	G
rs1749824	19929986	9242	MSC	umls:C0022661	BeFree	We observed the strongest evidence for association between ESRD and rs1749824, located in the ZMIZ1 gene [OR = 1.47 (1.21-1.78) per copy of T allele; P = 8.1 x 10(-5)] and rs9298190, located in the musculin gene [OR = 1.56 (1.28-1.91) per copy of C allele; P = 1.6 x 10(-5)].	0.000271442	2009	ZMIZ1	10	79164105	C	A
rs17709344	24871321	283652	SLC24A5	umls:C0022661	BeFree	Five genetic loci (WNT4/ZBTB40-rs12137135, RGMA/MCTP2-rs17709344, MAPRE1P2-rs1670754, SEMA6D/SLC24A5-rs12917114 and SIK1-rs2838302) were associated with ESRD in the FinnDiane study.	0.000271442	2014	NA	15	93608310	G	A
rs17709344	24871321	102724428	LOC102724428	umls:C0022661	BeFree	Five genetic loci (WNT4/ZBTB40-rs12137135, RGMA/MCTP2-rs17709344, MAPRE1P2-rs1670754, SEMA6D/SLC24A5-rs12917114 and SIK1-rs2838302) were associated with ESRD in the FinnDiane study.	0.000271442	2014	NA	15	93608310	G	A
rs1799945	16138214	3077	HFE	umls:C0022661	BeFree	We analyzed the frequency of the C282Y and H63D mutations in the HFE gene in 201 Brazilian individuals with CRI undergoing hemodialysis.	0.005276948	2005	HFE	6	26090951	C	G
rs1799983	23464568	4846	NOS3	umls:C0022661	BeFree	Association of endothelial nitric oxide synthase Glu298Asp gene polymorphism with the risk of end-stage renal disease.	0.13744224	2013	NOS3	7	150999023	T	G
rs1799983	15287194	4846	NOS3	umls:C0022661	BeFree	The endothelial nitric oxide synthase Glu298Asp and Asp29Asp genotypes were significantly more frequent in rapid progressors (9.6% (7/73) Asp/Asp, 39.7% (29/73) Asp/Glu, 50.7% (37/73) Glu/Glu) and in ADPKD group with ESRF between 40-63 years (11.3% (16/142) Asp/Asp, 41.5% (59/142) Asp/Glu, 47.2% (67/142) Glu/Glu) in comparison with slow progressors (8.8% (8/91) Asp/Asp, 24.2% (22/91) Asp/Glu, 67.0% (61/91) Glu/Glu) and with control group (8% Asp/Asp, 32% Asp/Glu, 60% Glu/Glu) (Chi-square test, p<0.05).	0.13744224	2004	NOS3	7	150999023	T	G
rs1799983	18413200	4846	NOS3	umls:C0022661	BeFree	In south Indian (SI) subjects there was significant allelic and genotypic association of the wild-type allele in SOD2 (Ala9Val; P=.002 and P=.013, respectively), UCP1 (-112 T>G, P=.012 and P=.009; Ala64Thr, P=.015 and P=.004), NOS3 (Glu298Asp, P=.002 and P=.009) and GSTP1 (Ile105Val, P=.003 and P=.004) genes with development of CRI.	0.13744224	2009	NOS3	7	150999023	T	G
rs1799983	18815450	4846	NOS3	umls:C0022661	BeFree	The distribution of C/T alleIes is significantly different between rapid and slow ADPKD progressors leading to the conclusion that the T allele of the Glu298Asp polymorphism of NOS3 gene is associated with earlier progression to ESRD in ADPKD patients.	0.13744224	2008	NOS3	7	150999023	T	G
rs1799983	19376104	4846	NOS3	umls:C0022661	BeFree	However, we found that eNOS G894T polymorphism was associated with the presence and severity of renal disease and with CVD in CRD patients (P=0.028, P=0.018, P=0.016 respectively).	0.13744224	2009	NOS3	7	150999023	T	G
rs1799983	18413200	7350	UCP1	umls:C0022661	BeFree	In south Indian (SI) subjects there was significant allelic and genotypic association of the wild-type allele in SOD2 (Ala9Val; P=.002 and P=.013, respectively), UCP1 (-112 T>G, P=.012 and P=.009; Ala64Thr, P=.015 and P=.004), NOS3 (Glu298Asp, P=.002 and P=.009) and GSTP1 (Ile105Val, P=.003 and P=.004) genes with development of CRI.	0.002638474	2009	NOS3	7	150999023	T	G
rs1799983	18793530	4846	NOS3	umls:C0022661	BeFree	Association of endothelial nitric oxide synthase Glu298Asp polymorphism with end-stage renal disease.	0.13744224	2008	NOS3	7	150999023	T	G
rs1799983	16364824	4846	NOS3	umls:C0022661	BeFree	Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease.	0.13744224	2005	NOS3	7	150999023	T	G
rs1799983	11823442	4846	NOS3	umls:C0022661	BeFree	In conclusion, the frequent Glu298Asp polymorphism of ENOS is associated with a 5 year lower mean age at ESRD in this subset of ADPKD males.	0.13744224	2002	NOS3	7	150999023	T	G
rs1799983	18413200	2950	GSTP1	umls:C0022661	BeFree	In south Indian (SI) subjects there was significant allelic and genotypic association of the wild-type allele in SOD2 (Ala9Val; P=.002 and P=.013, respectively), UCP1 (-112 T>G, P=.012 and P=.009; Ala64Thr, P=.015 and P=.004), NOS3 (Glu298Asp, P=.002 and P=.009) and GSTP1 (Ile105Val, P=.003 and P=.004) genes with development of CRI.	0.005634266	2009	NOS3	7	150999023	T	G
rs1799998	12832734	1585	CYP11B2	umls:C0022661	BeFree	We studied retrospectively the role of angiotensinogen (AGT) M235T, angiotensin converting enzyme (ACE) insertion/deletion (I/D), angiotensin II type 1 receptor (AT1R) A1166C, aldosterone syntase (CYP11B2) -344C/T and intron 2 W/C polymorphisms in conjunction with clinical and biochemical covariables on the rate of progression of renal insufficiency in a group of patients with ESRD of various etiologies.	0.00764398	2003	CYP11B2;LOC105375793	8	142918184	A	G
rs1799998	12832734	183	AGT	umls:C0022661	BeFree	We studied retrospectively the role of angiotensinogen (AGT) M235T, angiotensin converting enzyme (ACE) insertion/deletion (I/D), angiotensin II type 1 receptor (AT1R) A1166C, aldosterone syntase (CYP11B2) -344C/T and intron 2 W/C polymorphisms in conjunction with clinical and biochemical covariables on the rate of progression of renal insufficiency in a group of patients with ESRD of various etiologies.	0.051021274	2003	CYP11B2;LOC105375793	8	142918184	A	G
rs1799998	12832734	1636	ACE	umls:C0022661	BeFree	We studied retrospectively the role of angiotensinogen (AGT) M235T, angiotensin converting enzyme (ACE) insertion/deletion (I/D), angiotensin II type 1 receptor (AT1R) A1166C, aldosterone syntase (CYP11B2) -344C/T and intron 2 W/C polymorphisms in conjunction with clinical and biochemical covariables on the rate of progression of renal insufficiency in a group of patients with ESRD of various etiologies.	0.224449632	2003	CYP11B2;LOC105375793	8	142918184	A	G
rs1800562	16138214	3077	HFE	umls:C0022661	BeFree	We analyzed the frequency of the C282Y and H63D mutations in the HFE gene in 201 Brazilian individuals with CRI undergoing hemodialysis.	0.005276948	2005	HFE	6	26092913	G	A
rs1800625	20185929	5891	MOK	umls:C0022661	GAD	[In summary, our study shows for the first time a link between RAGE and GLO polymorphisms in the prognosis of HD patients.]	0.002367032	2010	AGER;PBX2	6	32184665	A	G
rs1801275	22817530	6775	STAT4	umls:C0022661	BeFree	Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model).	0.000542884	2012	IL4R	16	27363079	A	G
rs1801275	22817530	6347	CCL2	umls:C0022661	BeFree	Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model).	0.207262917	2012	IL4R	16	27363079	A	G
rs1805087	11592445	213	ALB	umls:C0022661	BeFree	To evaluate the respective roles of residual glomerular filtration (by measuring a specific protein marker, cystatin C), genetic polymorphisms and nutritional status in tHcy blood levels in end-stage renal disease patients (ESRD) under hemodialysis and supplemented with folate, we measured tHcy, folate, vitamin B12 (B12), creatinine, cystatin C, albumin and C-reactive protein and determined the polymorphism of methylenetetrahydrofolate reductase (MTHFR) (C677T and A1289C) and of methionine synthase (MS) (A2756G) in 114 ESRD patients before hemodialysis and 76 control subjects.	0.122985861	2001	MTR	1	236885200	A	G
rs1805087	11592445	4524	MTHFR	umls:C0022661	BeFree	To evaluate the respective roles of residual glomerular filtration (by measuring a specific protein marker, cystatin C), genetic polymorphisms and nutritional status in tHcy blood levels in end-stage renal disease patients (ESRD) under hemodialysis and supplemented with folate, we measured tHcy, folate, vitamin B12 (B12), creatinine, cystatin C, albumin and C-reactive protein and determined the polymorphism of methylenetetrahydrofolate reductase (MTHFR) (C677T and A1289C) and of methionine synthase (MS) (A2756G) in 114 ESRD patients before hemodialysis and 76 control subjects.	0.063333304	2001	MTR	1	236885200	A	G
rs1805087	11592445	1401	CRP	umls:C0022661	BeFree	To evaluate the respective roles of residual glomerular filtration (by measuring a specific protein marker, cystatin C), genetic polymorphisms and nutritional status in tHcy blood levels in end-stage renal disease patients (ESRD) under hemodialysis and supplemented with folate, we measured tHcy, folate, vitamin B12 (B12), creatinine, cystatin C, albumin and C-reactive protein and determined the polymorphism of methylenetetrahydrofolate reductase (MTHFR) (C677T and A1289C) and of methionine synthase (MS) (A2756G) in 114 ESRD patients before hemodialysis and 76 control subjects.	0.128544182	2001	MTR	1	236885200	A	G
rs1805087	11592445	4548	MTR	umls:C0022661	BeFree	To evaluate the respective roles of residual glomerular filtration (by measuring a specific protein marker, cystatin C), genetic polymorphisms and nutritional status in tHcy blood levels in end-stage renal disease patients (ESRD) under hemodialysis and supplemented with folate, we measured tHcy, folate, vitamin B12 (B12), creatinine, cystatin C, albumin and C-reactive protein and determined the polymorphism of methylenetetrahydrofolate reductase (MTHFR) (C677T and A1289C) and of methionine synthase (MS) (A2756G) in 114 ESRD patients before hemodialysis and 76 control subjects.	0.000271442	2001	MTR	1	236885200	A	G
rs196912	21085059	2081	ERN1	umls:C0022661	GAD	[Center-to-center variation is a major challenge to genomic studies focused on AR. The SNPs associated with AR and severity of tubulitis in this study will need to be validated in independent cohort of kidney transplant recipients.]	0.002367032	2010	ERN1	17	64044120	T	C
rs200042397	23800802	7827	NPHS2	umls:C0022661	BeFree	A family with three members homozygous for the NPHS2 p.R229Q variant is presented: a 37-year-old patient who was diagnosed with proteinuria at age 7 months, focal segmental glomerulosclerosis (FSGS) at age 20 years, and end-stage renal disease (ESRD) at age 33 years, his 59 year-old father and his 40 year-old brother, both unaffected with no proteinuria.	0.018717015	2013	NPHS2;AXDND1	1	179552616	T	C
rs200042397	22228437	7827	NPHS2	umls:C0022661	BeFree	Our results offer more evidence that in patients with FH, NPHS2-R229Q predisposes to proteinuria and ESKD.	0.018717015	2012	NPHS2;AXDND1	1	179552616	T	C
rs2017662	21085059	608	TNFRSF17	umls:C0022661	GAD	[Center-to-center variation is a major challenge to genomic studies focused on AR. The SNPs associated with AR and severity of tubulitis in this study will need to be validated in independent cohort of kidney transplant recipients.]	0.002367032	2010	TNFRSF17	16	11967769	G	A
rs2032487	21968013	4627	MYH9	umls:C0022661	BeFree	MYH9 SNPs rs4821480, rs2032487, rs4281481 and rs3752462 are associated with T2DM-ESRD susceptibility in European Americans.	0.133887143	2012	MYH9	22	36299382	C	T
rs2072651	21085059	1200	TPP1	umls:C0022661	GAD	[Center-to-center variation is a major challenge to genomic studies focused on AR. The SNPs associated with AR and severity of tubulitis in this study will need to be validated in independent cohort of kidney transplant recipients.]	0.002367032	2010	TPP1	11	6616273	G	A
rs2227931	21085059	545	ATR	umls:C0022661	GAD	[Center-to-center variation is a major challenge to genomic studies focused on AR. The SNPs associated with AR and severity of tubulitis in this study will need to be validated in independent cohort of kidney transplant recipients.]	0.002367032	2010	ATR	3	142503442	A	G
rs2228224	21085059	2735	GLI1	umls:C0022661	GAD	[Center-to-center variation is a major challenge to genomic studies focused on AR. The SNPs associated with AR and severity of tubulitis in this study will need to be validated in independent cohort of kidney transplant recipients.]	0.002367032	2010	GLI1	12	57471538	G	A
rs2229569	22119815	6402	SELL	umls:C0022661	BeFree	Investigation of P213S SELL gene polymorphism in type 2 diabetes mellitus and related end stage renal disease. A case-control study.	0.002638474	2011	SELL	1	169704697	G	T,A
rs2267130	21085059	11200	CHEK2	umls:C0022661	GAD	[Center-to-center variation is a major challenge to genomic studies focused on AR. The SNPs associated with AR and severity of tubulitis in this study will need to be validated in independent cohort of kidney transplant recipients.]	0.002367032	2010	CHEK2	22	28703766	T	C
rs2292832	24978643	406941	MIR149	umls:C0022661	BeFree	The aim of this study was to investigate the impact of MIR146A C>G (rs2910164), MIR149 T>C (rs2292832), MIR196A2 T>C (rs11614913), and MIR499A A>G (rs3746444) single nucleotide polymorphisms (SNPs) among end-stage renal disease (ESRD) and acute allograft rejection (AR) cases.	0.000271442	2015	GPC1;MIR149;PP14571	2	240456086	T	C
rs2292832	24978643	406938	MIR146A	umls:C0022661	BeFree	The aim of this study was to investigate the impact of MIR146A C>G (rs2910164), MIR149 T>C (rs2292832), MIR196A2 T>C (rs11614913), and MIR499A A>G (rs3746444) single nucleotide polymorphisms (SNPs) among end-stage renal disease (ESRD) and acute allograft rejection (AR) cases.	0.000271442	2015	GPC1;MIR149;PP14571	2	240456086	T	C
rs2292832	24978643	574501	MIR499A	umls:C0022661	BeFree	The aim of this study was to investigate the impact of MIR146A C>G (rs2910164), MIR149 T>C (rs2292832), MIR196A2 T>C (rs11614913), and MIR499A A>G (rs3746444) single nucleotide polymorphisms (SNPs) among end-stage renal disease (ESRD) and acute allograft rejection (AR) cases.	0.000542884	2015	GPC1;MIR149;PP14571	2	240456086	T	C
rs2292832	24978643	406973	MIR196A2	umls:C0022661	BeFree	The aim of this study was to investigate the impact of MIR146A C>G (rs2910164), MIR149 T>C (rs2292832), MIR196A2 T>C (rs11614913), and MIR499A A>G (rs3746444) single nucleotide polymorphisms (SNPs) among end-stage renal disease (ESRD) and acute allograft rejection (AR) cases.	0.000271442	2015	GPC1;MIR149;PP14571	2	240456086	T	C
rs25487	22302399	7515	XRCC1	umls:C0022661	BeFree	DNA repair XRCC1 Arg399Gln polymorphism is associated with the risk of development of end-stage renal disease.	0.000814326	2012	XRCC1	19	43551574	T	C
rs2648862	17881614	391191	OR2AK2	umls:C0022661	BeFree	Markers rs13447075 (odds ratio [OR] 1.47 [95% CI 1.14-1.89] per copy of A allele; P = 0.003) and rs2648862 (2.66 [1.19-5.92] per copy of C allele; P = 0.008) were strongly associated with ESRD in analyses adjusting for age(2), age(3), duration of diabetes, and smoking status.	0.000271442	2007	PVT1;MIR1207	8	128049539	C	A
rs2648875	17395743	5820	PVT1	umls:C0022661	GAD	[Identification of PVT1 as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study.]	0.01099709	2007	PVT1	8	128059915	G	A
rs2802723	24157943	7827	NPHS2	umls:C0022661	BeFree	The minor allele in NPHS2 markedly changed the APOL1-ESKD association odds ratio (OR) from 7.03 to 1.76 (∼50% reduction in effect per copy of the minor allele), rs2802723 changed the OR from 5.1 to 10.5, and rs8014363 increased the OR from 4.8 to 9.5.	0.018717015	2015	SDCCAG8	1	243335010	T	C
rs2838302	24871321	283652	SLC24A5	umls:C0022661	BeFree	Five genetic loci (WNT4/ZBTB40-rs12137135, RGMA/MCTP2-rs17709344, MAPRE1P2-rs1670754, SEMA6D/SLC24A5-rs12917114 and SIK1-rs2838302) were associated with ESRD in the FinnDiane study.	0.000271442	2014	SIK1	21	43419273	A	G
rs2838302	24871321	102724428	LOC102724428	umls:C0022661	BeFree	Five genetic loci (WNT4/ZBTB40-rs12137135, RGMA/MCTP2-rs17709344, MAPRE1P2-rs1670754, SEMA6D/SLC24A5-rs12917114 and SIK1-rs2838302) were associated with ESRD in the FinnDiane study.	0.000271442	2014	SIK1	21	43419273	A	G
rs2910164	24978643	406973	MIR196A2	umls:C0022661	BeFree	The aim of this study was to investigate the impact of MIR146A C>G (rs2910164), MIR149 T>C (rs2292832), MIR196A2 T>C (rs11614913), and MIR499A A>G (rs3746444) single nucleotide polymorphisms (SNPs) among end-stage renal disease (ESRD) and acute allograft rejection (AR) cases.	0.000271442	2015	LOC285628;MIR146A	5	160485411	C	G
rs2910164	24978643	406938	MIR146A	umls:C0022661	BeFree	The aim of this study was to investigate the impact of MIR146A C>G (rs2910164), MIR149 T>C (rs2292832), MIR196A2 T>C (rs11614913), and MIR499A A>G (rs3746444) single nucleotide polymorphisms (SNPs) among end-stage renal disease (ESRD) and acute allograft rejection (AR) cases.	0.000271442	2015	LOC285628;MIR146A	5	160485411	C	G
rs2910164	24978643	574501	MIR499A	umls:C0022661	BeFree	The aim of this study was to investigate the impact of MIR146A C>G (rs2910164), MIR149 T>C (rs2292832), MIR196A2 T>C (rs11614913), and MIR499A A>G (rs3746444) single nucleotide polymorphisms (SNPs) among end-stage renal disease (ESRD) and acute allograft rejection (AR) cases.	0.000542884	2015	LOC285628;MIR146A	5	160485411	C	G
rs2910164	24978643	406941	MIR149	umls:C0022661	BeFree	The aim of this study was to investigate the impact of MIR146A C>G (rs2910164), MIR149 T>C (rs2292832), MIR196A2 T>C (rs11614913), and MIR499A A>G (rs3746444) single nucleotide polymorphisms (SNPs) among end-stage renal disease (ESRD) and acute allograft rejection (AR) cases.	0.000271442	2015	LOC285628;MIR146A	5	160485411	C	G
rs301640	22817530	6775	STAT4	umls:C0022661	BeFree	Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model).	0.000542884	2012	NA	13	60885853	C	T
rs301640	22817530	6347	CCL2	umls:C0022661	BeFree	Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model).	0.207262917	2012	NA	13	60885853	C	T
rs3088142	21085059	51207	DUSP13	umls:C0022661	GAD	[Center-to-center variation is a major challenge to genomic studies focused on AR. The SNPs associated with AR and severity of tubulitis in this study will need to be validated in independent cohort of kidney transplant recipients.]	0.002367032	2010	DUSP13	10	75094806	C	T
rs3093816	21085059	902	CCNH	umls:C0022661	GAD	[Center-to-center variation is a major challenge to genomic studies focused on AR. The SNPs associated with AR and severity of tubulitis in this study will need to be validated in independent cohort of kidney transplant recipients.]	0.002367032	2010	CCNH	5	87401570	A	G
rs3125001	21085059	4851	NOTCH1	umls:C0022661	GAD	[Center-to-center variation is a major challenge to genomic studies focused on AR. The SNPs associated with AR and severity of tubulitis in this study will need to be validated in independent cohort of kidney transplant recipients.]	0.002367032	2010	NOTCH1	9	136510809	C	A,T
rs315952	17176440	3557	IL1RN	umls:C0022661	BeFree	Using IL1RN as a possible marker in patients with systemic lupus erythematosus (SLE), we evaluated whether uIL1RN single nucleotide polymorphisms (SNPs) were associated with the pathogenesis of SLE in Taiwanese, and specifically whether IL1RN (rs315952) was significantly associated with end-stage renal disease.	0.021465109	2006	IL1RN	2	113132727	T	A,C
rs35238405	24948143	8542	APOL1	umls:C0022661	BeFree	Initial analysis identified rs35238405 (T233A; minor allele frequency=0.0096) as associated with type 2 diabetic end stage renal disease (adjustment for admixture P=0.042; adjustment for admixture+APOL1 P=0.080; odds ratio, 2.89 and 2.36, respectively); with replication in independent type 2 diabetic end stage renal disease samples (P=0.018; odds ratio, 4.30) and nondiabetic end stage renal disease samples (P=0.016; odds ratio, 4.48).	0.009967404	2015	NPHS1	19	35849565	T	C
rs3732378	12846758	1524	CX3CR1	umls:C0022661	BeFree	The -174G/C polymorphism of the IL-6 gene and the chemokine receptor CX3CR1 polymorphisms 249V/I and 280T/M were examined for their association with cardiovascular abnormalities in a cohort of 161 patients with end-stage renal disease (ESRD) treated by hemodialysis.	0.002909916	2003	CX3CR1	3	39265671	G	A
rs3732378	12846758	3569	IL6	umls:C0022661	BeFree	The -174G/C polymorphism of the IL-6 gene and the chemokine receptor CX3CR1 polymorphisms 249V/I and 280T/M were examined for their association with cardiovascular abnormalities in a cohort of 161 patients with end-stage renal disease (ESRD) treated by hemodialysis.	0.152647765	2003	CX3CR1	3	39265671	G	A
rs3732379	12846758	3569	IL6	umls:C0022661	BeFree	The -174G/C polymorphism of the IL-6 gene and the chemokine receptor CX3CR1 polymorphisms 249V/I and 280T/M were examined for their association with cardiovascular abnormalities in a cohort of 161 patients with end-stage renal disease (ESRD) treated by hemodialysis.	0.152647765	2003	CX3CR1	3	39265765	C	T
rs3732379	12846758	1524	CX3CR1	umls:C0022661	BeFree	The -174G/C polymorphism of the IL-6 gene and the chemokine receptor CX3CR1 polymorphisms 249V/I and 280T/M were examined for their association with cardiovascular abnormalities in a cohort of 161 patients with end-stage renal disease (ESRD) treated by hemodialysis.	0.002909916	2003	CX3CR1	3	39265765	C	T
rs3746444	24978643	574501	MIR499A	umls:C0022661	BeFree	The aim of this study was to investigate the impact of MIR146A C>G (rs2910164), MIR149 T>C (rs2292832), MIR196A2 T>C (rs11614913), and MIR499A A>G (rs3746444) single nucleotide polymorphisms (SNPs) among end-stage renal disease (ESRD) and acute allograft rejection (AR) cases.	0.000542884	2015	MYH7B;MIR499A;MIR499B	20	34990448	A	G
rs3746444	24978643	406973	MIR196A2	umls:C0022661	BeFree	The aim of this study was to investigate the impact of MIR146A C>G (rs2910164), MIR149 T>C (rs2292832), MIR196A2 T>C (rs11614913), and MIR499A A>G (rs3746444) single nucleotide polymorphisms (SNPs) among end-stage renal disease (ESRD) and acute allograft rejection (AR) cases.	0.000271442	2015	MYH7B;MIR499A;MIR499B	20	34990448	A	G
rs3746444	24978643	406941	MIR149	umls:C0022661	BeFree	The aim of this study was to investigate the impact of MIR146A C>G (rs2910164), MIR149 T>C (rs2292832), MIR196A2 T>C (rs11614913), and MIR499A A>G (rs3746444) single nucleotide polymorphisms (SNPs) among end-stage renal disease (ESRD) and acute allograft rejection (AR) cases.	0.000271442	2015	MYH7B;MIR499A;MIR499B	20	34990448	A	G
rs3746444	24978643	406938	MIR146A	umls:C0022661	BeFree	The aim of this study was to investigate the impact of MIR146A C>G (rs2910164), MIR149 T>C (rs2292832), MIR196A2 T>C (rs11614913), and MIR499A A>G (rs3746444) single nucleotide polymorphisms (SNPs) among end-stage renal disease (ESRD) and acute allograft rejection (AR) cases.	0.000271442	2015	MYH7B;MIR499A;MIR499B	20	34990448	A	G
rs3752462	21968013	4627	MYH9	umls:C0022661	BeFree	MYH9 SNPs rs4821480, rs2032487, rs4281481 and rs3752462 are associated with T2DM-ESRD susceptibility in European Americans.	0.133887143	2012	MYH9	22	36314138	T	C
rs3759126	17763164	359	AQP2	umls:C0022661	BeFree	Genotype and allele frequencies of the AQP-2 gene polymorphism (rs3759126) of hypertensive patients in pre-ESRD did not show a noticeable difference compared with normal blood pressure patients in pre-ESRD (p = 0.50).	0.002638474	2007	AQP2	12	49950079	A	G
rs3783408	21085059	11183	MAP4K5	umls:C0022661	GAD	[Center-to-center variation is a major challenge to genomic studies focused on AR. The SNPs associated with AR and severity of tubulitis in this study will need to be validated in independent cohort of kidney transplant recipients.]	0.002638474	2010	MAP4K5;ATL1	14	50533475	C	T
rs3803800	24811838	3493	IGHA1	umls:C0022661	BeFree	Association between rs3803800 and serum IgA was replicated, and risk groups in GRSs were associated with increased IgA/IgA1 levels. uwGRS9 ≥ 16 was an independent predictor for end stage renal disease (ESRD) in IgAN, with a relative risk of 2.52 (p = 6.68 × 10(-3)).	0.000271442	2014	TNFSF13;TNFSF12-TNFSF13	17	7559652	A	G
rs386493716	22302399	7515	XRCC1	umls:C0022661	BeFree	DNA repair XRCC1 Arg399Gln polymorphism is associated with the risk of development of end-stage renal disease.	0.000814326	2012	NA	NA	NA	NA	NA
rs3917887	25280384	6347	CCL2	umls:C0022661	BeFree	Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy.	0.207262917	2014	CCL2	17	34255980	AGCTCCTCCTTCTC	-
rs3917887	25280384	7422	VEGFA	umls:C0022661	BeFree	Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy.	0.014992773	2014	CCL2	17	34255980	AGCTCCTCCTTCTC	-
rs3925584	22479191	744	MPPED2	umls:C0022661	GAD	[Genome-wide association and functional follow-up reveals new loci for kidney function.]	0.002367032	2012	NA	11	30738788	T	C
rs3957357	24423050	2952	GSTT1	umls:C0022661	BeFree	We examined association between GSTM1 and GSTT1 deletion polymorphisms as well as SNPs in GSTA1/rs3957357 and GSTP1/rs1695 genes with overall and cause-specific cardiovascular mortality in ESRD patients.	0.008544182	2013	GSTA1	6	52803889	A	G
rs397507444	19272686	4524	MTHFR	umls:C0022661	BeFree	Effect of the MTHFR C677T and A1298C polymorphisms on survival in patients with advanced CKD and ESRD: a prospective study.	0.063333304	2009	MTHFR	1	11794407	T	G
rs397507444	19376104	4524	MTHFR	umls:C0022661	BeFree	We used PCR-RFLP analysis to detect the eNOS G894T, MTHFR C677T and A1298C variants in 100 patients with CRD and in 120 healthy controls.	0.063333304	2009	MTHFR	1	11794407	T	G
rs397507444	17899317	4524	MTHFR	umls:C0022661	BeFree	MTHFR A1298C polymorphism is associated with cardiovascular risk in end stage renal disease in North Indians.	0.063333304	2008	MTHFR	1	11794407	T	G
rs41302867	25027322	183	AGT	umls:C0022661	BeFree	Examination of exome sequencing data in African American T2D-ESKD cases and non-diabetic non-nephropathy controls identified two low-frequency variants in the RREB1 gene, a repressor of the angiotensinogen (AGT) gene previously associated with kidney function, as being associated with T2D-ESKD: rs9379084 (P = 0.00087, OR = 0.26; D1171N) and rs41302867 (P = 0.00078, OR = 0.21; splice site variant).	0.051021274	2015	RREB1	6	7240643	G	A
rs4281481	21968013	4627	MYH9	umls:C0022661	BeFree	MYH9 SNPs rs4821480, rs2032487, rs4281481 and rs3752462 are associated with T2DM-ESRD susceptibility in European Americans.	0.133887143	2012	CCDC179;LOC105376590	11	22859013	C	G
rs4348159	21085059	7364	UGT2B7	umls:C0022661	GAD	[Center-to-center variation is a major challenge to genomic studies focused on AR. The SNPs associated with AR and severity of tubulitis in this study will need to be validated in independent cohort of kidney transplant recipients.]	0.002367032	2010	UGT2B7	4	69107234	C	A,T
rs452204	20551628	3552	IL1A	umls:C0022661	BeFree	Investigating all common variants in IL1A, IL1B, IL1RN,IL6 and IL10 genes revealed a statistically significant association (rs452204 p(empirical) = 0.02) with one IL1RN variant and ESRD.	0.006362715	2010	IL1RN	2	113131484	G	A
rs452204	20551628	3586	IL10	umls:C0022661	BeFree	Investigating all common variants in IL1A, IL1B, IL1RN,IL6 and IL10 genes revealed a statistically significant association (rs452204 p(empirical) = 0.02) with one IL1RN variant and ESRD.	0.028652081	2010	IL1RN	2	113131484	G	A
rs452204	20551628	3553	IL1B	umls:C0022661	BeFree	Investigating all common variants in IL1A, IL1B, IL1RN,IL6 and IL10 genes revealed a statistically significant association (rs452204 p(empirical) = 0.02) with one IL1RN variant and ESRD.	0.095916719	2010	IL1RN	2	113131484	G	A
rs452204	20551628	3569	IL6	umls:C0022661	BeFree	Investigating all common variants in IL1A, IL1B, IL1RN,IL6 and IL10 genes revealed a statistically significant association (rs452204 p(empirical) = 0.02) with one IL1RN variant and ESRD.	0.152647765	2010	IL1RN	2	113131484	G	A
rs452204	20551628	3557	IL1RN	umls:C0022661	BeFree	Investigating all common variants in IL1A, IL1B, IL1RN,IL6 and IL10 genes revealed a statistically significant association (rs452204 p(empirical) = 0.02) with one IL1RN variant and ESRD.	0.021465109	2010	IL1RN	2	113131484	G	A
rs45539933	18413200	4846	NOS3	umls:C0022661	BeFree	In south Indian (SI) subjects there was significant allelic and genotypic association of the wild-type allele in SOD2 (Ala9Val; P=.002 and P=.013, respectively), UCP1 (-112 T>G, P=.012 and P=.009; Ala64Thr, P=.015 and P=.004), NOS3 (Glu298Asp, P=.002 and P=.009) and GSTP1 (Ile105Val, P=.003 and P=.004) genes with development of CRI.	0.13744224	2009	UCP1	4	140567914	C	T
rs45539933	18413200	7350	UCP1	umls:C0022661	BeFree	In south Indian (SI) subjects there was significant allelic and genotypic association of the wild-type allele in SOD2 (Ala9Val; P=.002 and P=.013, respectively), UCP1 (-112 T>G, P=.012 and P=.009; Ala64Thr, P=.015 and P=.004), NOS3 (Glu298Asp, P=.002 and P=.009) and GSTP1 (Ile105Val, P=.003 and P=.004) genes with development of CRI.	0.002638474	2009	UCP1	4	140567914	C	T
rs45539933	18413200	2950	GSTP1	umls:C0022661	BeFree	In south Indian (SI) subjects there was significant allelic and genotypic association of the wild-type allele in SOD2 (Ala9Val; P=.002 and P=.013, respectively), UCP1 (-112 T>G, P=.012 and P=.009; Ala64Thr, P=.015 and P=.004), NOS3 (Glu298Asp, P=.002 and P=.009) and GSTP1 (Ile105Val, P=.003 and P=.004) genes with development of CRI.	0.005634266	2009	UCP1	4	140567914	C	T
rs4586	22817530	6775	STAT4	umls:C0022661	BeFree	Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model).	0.000542884	2012	CCL2	17	34256250	T	C
rs4586	22817530	6347	CCL2	umls:C0022661	BeFree	Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model).	0.207262917	2012	CCL2	17	34256250	T	C
rs4746	20185929	2739	GLO1	umls:C0022661	GAD	[In summary, our study shows for the first time a link between RAGE and GLO polymorphisms in the prognosis of HD patients.]	0.004734064	2010	GLO1	6	38682852	T	G
rs4819554	23147652	26246	OR2L2	umls:C0022661	BeFree	Genotyping analysis demonstrated that 2 SNPs among 13 were significantly associated with ESRD after adjusting for age and sex, which were shown by IL17E rs10137082 (odds ratio (OR) 1.48 in codominant 1, OR 1.54 in dominant, OR 1.47 in log-additive) and IL17RA rs4819554 (OR 1.46 in codominant 1, OR 1.79 in codominant 2, OR 1.54 in dominant, OR 1.39 in log-additive).	0.000271442	2012	IL17RA	22	17084145	G	A
rs4819554	25636567	23765	IL17RA	umls:C0022661	BeFree	Allele rs4819554 A had been associated to the risk of developing end stage renal disease, and was also linked to an increased expression of the IL17RA protein and higher levels of Th17 cell subsets.	0.000542884	2015	IL17RA	22	17084145	G	A
rs4821469	20532800	80832	APOL4	umls:C0022661	GAD	[Candidate genes for non-diabetic ESRD in African Americans: a genome-wide association study using pooled DNA.]	0.002367032	2010	NA	22	36220399	T	C
rs4821480	21968013	4627	MYH9	umls:C0022661	BeFree	MYH9 SNPs rs4821480, rs2032487, rs4281481 and rs3752462 are associated with T2DM-ESRD susceptibility in European Americans.	0.133887143	2012	MYH9	22	36299201	G	T
rs4839469	21085059	81839	VANGL1	umls:C0022661	GAD	[Center-to-center variation is a major challenge to genomic studies focused on AR. The SNPs associated with AR and severity of tubulitis in this study will need to be validated in independent cohort of kidney transplant recipients.]	0.002367032	2010	VANGL1	1	115663802	G	A,C
rs4961	13679477	1636	ACE	umls:C0022661	BeFree	In this large series of ADPKD patients, we found no effect of the ACE (I/D) polymorphism on the age at ESRD, either alone or in combination with the G460W polymorphism of ADD.	0.224449632	2003	ADD1	4	2904980	G	T
rs4961	13679477	118	ADD1	umls:C0022661	BeFree	In this large series of ADPKD patients, we found no effect of the ACE (I/D) polymorphism on the age at ESRD, either alone or in combination with the G460W polymorphism of ADD.	0.00554839	2003	ADD1	4	2904980	G	T
rs515299	15800115	3075	CFH	umls:C0022661	BeFree	In addition, a heterozygous mutation (causing an S890I change) in factor H of complement was found in the patient who developed chronic renal failure but not in her sister, who presented with exclusive neurologic symptoms.	0.009077134	2005	CFH	1	196737547	G	T,C,A
rs5186	19954723	185	AGTR1	umls:C0022661	BeFree	The angiotensin II Type 1 receptor (AT1R) A1166C (rs5186) genez polymorphism is equivocally associated with the patients' susceptibility to chronic kidney disease or end-stage renal disease.	0.048293042	2009	AGTR1	3	148742201	A	C
rs524	21085059	23645	PPP1R15A	umls:C0022661	GAD	[Center-to-center variation is a major challenge to genomic studies focused on AR. The SNPs associated with AR and severity of tubulitis in this study will need to be validated in independent cohort of kidney transplant recipients.]	0.002367032	2010	PPP1R15A	19	48875910	C	T
rs5443	12000471	2784	GNB3	umls:C0022661	BeFree	In conclusion, in a sizeable number of pediatric renal transplant recipients the GNB3 C825T polymorphism was found not to be a genetic risk factor for end-stage kidney disease.	0.00764398	2002	GNB3;CDCA3	12	6845711	C	T
rs5443	11684796	2784	GNB3	umls:C0022661	BeFree	The results of our study suggest that GNB3 C825T polymorphism does not contribute substantially to the increased risk of the development of ESRD.	0.00764398	2001	GNB3;CDCA3	12	6845711	C	T
rs5498	22609477	3383	ICAM1	umls:C0022661	BeFree	The intercellular adhesion molecule-1 (ICAM-1) gene polymorphism K469E in end-stage renal disease patients with cardiovascular disease.	0.088001298	2012	ICAM1;ICAM4;LOC105372272	19	10285007	A	G
rs5743836	23472199	54106	TLR9	umls:C0022661	BeFree	Role of the functional Toll-Like receptor-9 promoter polymorphism (-1237T/C) in increased risk of end-stage renal disease: a case-control study.	0.000271442	2013	TLR9	3	52226766	A	G
rs6163	21085059	1586	CYP17A1	umls:C0022661	GAD	[Center-to-center variation is a major challenge to genomic studies focused on AR. The SNPs associated with AR and severity of tubulitis in this study will need to be validated in independent cohort of kidney transplant recipients.]	0.002367032	2010	CYP17A1	10	102837167	C	A,T
rs6431731	22479191	1653	DDX1	umls:C0022661	GAD	[Genome-wide association and functional follow-up reveals new loci for kidney function.]	0.002367032	2012	NA	2	15722878	C	T
rs671	18974607	217	ALDH2	umls:C0022661	GAD	[Influence of ALDH2 genetic polymorphisms on aciclovir pharmacokinetics following oral administration of valaciclovir in Japanese end-stage renal disease patients.]	0.002367032	2008	ALDH2	12	111803962	G	A
rs7583877	23028342	3899	AFF3	umls:C0022661	BeFree	After additional genotyping of 41 top ranked SNPs representing 24 independent signals in 5,873 individuals, combined meta-analysis revealed association of two SNPs with ESRD: rs7583877 in the AFF3 gene (P = 1.2 × 10(-8)) and an intergenic SNP on chromosome 15q26 between the genes RGMA and MCTP2, rs12437854 (P = 2.0 × 10(-9)).	0.000271442	2012	AFF3	2	99844192	C	T
rs7583877	23028342	55784	MCTP2	umls:C0022661	BeFree	After additional genotyping of 41 top ranked SNPs representing 24 independent signals in 5,873 individuals, combined meta-analysis revealed association of two SNPs with ESRD: rs7583877 in the AFF3 gene (P = 1.2 × 10(-8)) and an intergenic SNP on chromosome 15q26 between the genes RGMA and MCTP2, rs12437854 (P = 2.0 × 10(-9)).	0.000542884	2012	AFF3	2	99844192	C	T
rs7583877	23028342	56963	RGMA	umls:C0022661	BeFree	After additional genotyping of 41 top ranked SNPs representing 24 independent signals in 5,873 individuals, combined meta-analysis revealed association of two SNPs with ESRD: rs7583877 in the AFF3 gene (P = 1.2 × 10(-8)) and an intergenic SNP on chromosome 15q26 between the genes RGMA and MCTP2, rs12437854 (P = 2.0 × 10(-9)).	0.000542884	2012	AFF3	2	99844192	C	T
rs7830	22817530	6775	STAT4	umls:C0022661	BeFree	Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model).	0.000542884	2012	NOS3;ATG9B	7	151012483	G	T
rs7830	22817530	6347	CCL2	umls:C0022661	BeFree	Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model).	0.207262917	2012	NOS3;ATG9B	7	151012483	G	T
rs8014363	24157943	7827	NPHS2	umls:C0022661	BeFree	The minor allele in NPHS2 markedly changed the APOL1-ESKD association odds ratio (OR) from 7.03 to 1.76 (∼50% reduction in effect per copy of the minor allele), rs2802723 changed the OR from 5.1 to 10.5, and rs8014363 increased the OR from 4.8 to 9.5.	0.018717015	2015	NA	14	53964857	C	T
rs833061	25280384	6347	CCL2	umls:C0022661	BeFree	Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy.	0.207262917	2014	VEGFA	6	43769749	C	T
rs833061	25280384	7422	VEGFA	umls:C0022661	BeFree	Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy.	0.014992773	2014	VEGFA	6	43769749	C	T
rs9298190	19929986	9242	MSC	umls:C0022661	BeFree	We observed the strongest evidence for association between ESRD and rs1749824, located in the ZMIZ1 gene [OR = 1.47 (1.21-1.78) per copy of T allele; P = 8.1 x 10(-5)] and rs9298190, located in the musculin gene [OR = 1.56 (1.28-1.91) per copy of C allele; P = 1.6 x 10(-5)].	0.000271442	2009	LOC100132891	8	71932099	T	C
rs9379084	25027322	183	AGT	umls:C0022661	BeFree	Examination of exome sequencing data in African American T2D-ESKD cases and non-diabetic non-nephropathy controls identified two low-frequency variants in the RREB1 gene, a repressor of the angiotensinogen (AGT) gene previously associated with kidney function, as being associated with T2D-ESKD: rs9379084 (P = 0.00087, OR = 0.26; D1171N) and rs41302867 (P = 0.00078, OR = 0.21; splice site variant).	0.051021274	2015	RREB1	6	7231610	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:314)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	15869899	rs12124078	A	G	rs12124078	22479191	9.49E-22	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	24552835	rs11249039	A	G	rs11249039	20222955	8.30E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
1	24556756	rs10903062	G	A	rs10903062	20222955	2.60E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
1	24572806	rs7517309	A	G	rs7517309	20222955	2.80E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
1	49203349	rs4926749	C	A	rs4926749	20222955	5.80E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
1	50591405	rs2494884	G	T	rs2494884	pha003069	7.70E-05	phs000221	phs000501	0.24	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2494884-T	NA	G
1	74069017	rs1566585	A	C	rs1566585	pha003069	2.93E-05	phs000221	phs000501	0.2	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs1566585-C	NA	A
1	74074098	rs11210304	A	G	rs11210304	pha003069	2.99E-05	phs000221	phs000501	0.2	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs11210304-G	NA	G,A
1	74087657	rs11210317	T	G	rs11210317	pha003069	2.79E-05	phs000221	phs000501	0.2	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs11210317-G	NA	T
1	102726399	rs17126268	T	C	rs17126268	24351856	9.64E-05	NA	2.78	NA	301 Sinhalese Sri Lankan ancestry cases; 276 Sinhalese Sri Lankan ancestry controls	Sinhalese(577)	ALL(577)	SAN(577)	ALL(577)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs17126268-T	Research Support, Non-U.S. Gov't	C	NA
1	102726802	rs7539242	G	A	rs7539242	24351856	9.64E-05	NA	2.78	NA	301 Sinhalese Sri Lankan ancestry cases; 276 Sinhalese Sri Lankan ancestry controls	Sinhalese(577)	ALL(577)	SAN(577)	ALL(577)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs7539242-C	Research Support, Non-U.S. Gov't	G	NA
1	102726802	rs7539242	G	A	rs7539242	24351856	9.64E-05	NA	2.78	NA	301 Sinhalese Sri Lankan ancestry cases; 276 Sinhalese Sri Lankan ancestry controls	Sinhalese(577)	ALL(577)	SAN(577)	ALL(577)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs7539242-G	Research Support, Non-U.S. Gov't	G	NA
1	102734951	rs12120258	G	T	rs12120258	24351856	9.64E-05	NA	2.78	NA	301 Sinhalese Sri Lankan ancestry cases; 276 Sinhalese Sri Lankan ancestry controls	Sinhalese(577)	ALL(577)	SAN(577)	ALL(577)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs12120258-G	Research Support, Non-U.S. Gov't	T	NA
1	102739517	rs12140211	C	T	rs12140211	24351856	7.59E-04	NA	2	NA	301 Sinhalese Sri Lankan ancestry cases; 276 Sinhalese Sri Lankan ancestry controls	Sinhalese(577)	ALL(577)	SAN(577)	ALL(577)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs12140211-C	Research Support, Non-U.S. Gov't	T,C	NA
1	109999838	rs1933182	A	C	rs1933182	20383146	1.00E-07	eGFRcrea	0.01	[0.006-0.010] ml/min/1.73m2 decrease	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs1933182-A	NA	T	NA
1	109999838	rs1933182	A	C	rs1933182	22479191	3.18E-07	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	150951477	rs267734	T	C	rs267734	20383146	1.00E-12	eGFRcrea	0.01	[0.004-0.016] unit increase	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs267734-C	NA	A	NA
1	150951477	rs267734	T	C	rs267734	22479191	3.66E-09	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
1	150997842	rs3738479	T	A	rs3738479	21931561	9.00E-04	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
1	166086171	rs4074897	G	A	rs4074897	23539754	0.000012	NA	NA	NA	252 Japanese ancestry cases; 249 Japanese ancestry controls	Japanese(501)	ALL(501)	ASN(501)	ALL(501)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, Non-U.S. Gov't	A	FAM78B
1	166130218	rs2116519	G	A	rs2116519	23539754	0.0000011	NA	NA	NA	252 Japanese ancestry cases; 249 Japanese ancestry controls	Japanese(501)	ALL(501)	ASN(501)	ALL(501)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, Non-U.S. Gov't	C	FAM78B
1	187573295	rs12075120	G	A	rs12075120	pha003069	1.44E-05	phs000221	phs000501	0.23	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs12075120-A	NA	G
1	187588239	rs12746529	T	C	rs12746529	pha003069	9.01E-06	phs000221	phs000501	0.23	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs12746529-C	NA	T
1	187623971	rs12749748	T	C	rs12749748	pha003069	2.85E-05	phs000221	phs000501	0.24	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs12749748-C	NA	T
1	187628458	rs10494602	C	T	rs10494602	pha003069	4.07E-05	phs000221	phs000501	0.24	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs10494602-T	NA	C
1	187681358	rs6425114	A	C	rs6425114	pha003069	7.48E-05	phs000221	phs000501	0.23	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs6425114-A	NA	C
1	192554431	rs6428106	G	T	rs6428106	21931561	2.95E-07	Chronic kidney disease	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
1	200022667	rs2737641	G	A	rs2737641	pha003069	3.30E-05	phs000221	phs000501	0.21	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2737641-A	NA	G
1	214439328	rs766499	A	C	rs766499	pha003069	7.09E-05	phs000221	phs000501	0.36	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs766499-A	NA	G,T
1	214457286	rs9970083	G	T	rs9970083	pha003069	2.80E-05	phs000221	phs000501	0.25	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs9970083-G	NA	T
1	214491961	rs12124666	C	T	rs12124666	pha003069	4.05E-05	phs000221	phs000501	0.3	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs12124666-C	NA	T
1	214492286	rs1134647	G	A	rs1134647	pha003069	4.00E-05	phs000221	phs000501	0.3	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs1134647-G	NA	A
1	216940621	rs6604644	A	G	rs6604644	pha003069	7.74E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs6604644-G	NA	A
1	229362876	rs932927	G	A	rs932927	pha003069	3.41E-05	phs000221	phs000501	0.21	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs932927-A	NA	C
1	233735468	rs1773950	C	T	rs1773950	pha003069	5.22E-05	phs000221	phs000501	0.33	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs1773950-C	NA	T
1	246586841	rs10924727	A	C	rs10924727	pha003069	9.05E-06	phs000221	phs000501	0.19	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs10924727-C	NA	A
2	5907880	rs16864170	T	C	rs16864170	20383146	2.00E-07	CKD	1.3	[1.18-1.43]	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs16864170-C	NA	T	NA
2	15863002	rs6431731	C	T	rs6431731	22479191	4.00E-08	NA	0.01	[0.0082-0.0172] ml/min/1.73m^2 decrease	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	27730940	rs1260326	T	C	rs1260326	20383146	3.00E-14	eGFRcrea	0.01	[0.007-0.011] unit increase	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs1260326-T	NA	C	GCKR
2	27730940	rs1260326	T	C	rs1260326	22479191	4.48E-12	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	29112852	rs13014379	T	C	rs13014379	22479191	6.10E-06	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	35073607	rs280691	T	C	rs280691	pha003069	1.66E-05	phs000221	phs000501	0.18	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs280691-T	NA	C
2	35092762	rs280754	C	T	rs280754	pha003069	6.17E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs280754-C	NA	G
2	72035671	rs17007417	T	C	rs17007417	pha003069	9.70E-05	phs000221	phs000501	0.23	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs17007417-T	NA	T
2	73677898	rs6546837	G	C	rs6546837	21931561	3.28E-08	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
2	73868328	rs13538	A	G	rs13538	20383146	5.00E-14	eGFRcrea	0.01	[0.005-0.013] unit increase	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs13538-G	NA	T	NAT8
2	73868328	rs13538	A	G	rs13538	22479191	6.98E-10	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	73900900	rs10206899	T	C	rs10206899	20383145	1.00E-15	NA	1	[0.7-1.2] % decrease	23,812 European descent individuals	European(23812)	ALL(23812)	EUR(23812)	ALL(23812)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs10206899-G	NA
2	119104699	rs13400406	T	C	rs13400406	pha003069	6.80E-05	phs000221	phs000501	0.26	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs13400406-C	NA	T,C
2	119106057	rs4560125	A	G	rs4560125	pha003069	2.54E-05	phs000221	phs000501	0.28	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4560125-G	NA	G
2	119110846	rs4849697	A	G	rs4849697	pha003069	9.41E-05	phs000221	phs000501	0.35	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4849697-G	NA	A
2	119112560	rs4594452	C	T	rs4594452	pha003069	4.95E-05	phs000221	phs000501	0.28	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4594452-T	NA	T
2	119147509	rs6708595	G	T	rs6708595	pha003069	4.75E-06	phs000221	phs000501	0.3	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs6708595-T	NA	G
2	201252335	rs3769451	A	G	rs3769451	pha003069	4.09E-06	phs000221	phs000501	0.23	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs3769451-G	NA	T
2	211540507	rs1047891	C	A	rs1047891	20383146	1.00E-15	NA	NA	NA	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	NA	C	CPS1
2	211540507	rs1047891	C	A	rs1047891	22479191	1.35E-10	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	211540507	rs1047891	C	A	rs7422339	20383146	1.00E-15	NA	0.01	[0.005-0.013] unit decrease	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs7422339-A	NA	C	CPS1
2	211554574	rs2887915	C	T	rs2887915	21931561	9.09E-08	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
2	228044992	rs2396463	C	A	rs2396463	20222955	1.50E-06	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
2	228052600	rs2204862	A	G	rs2204862	20222955	4.80E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
3	23093574	rs9310709	T	C	rs9310709	20686651	2.00E-06	CKD	1.15	[1.09-1.22]	2,903 Icelandic CKD cases; 35,818 Icelandic controls; 22,256 Icelandic subjects with serum creatinine	Icelandic(60977)	ALL(60977)	EUR(60977)	ALL(60977)	Chronic kidney disease and serum creatinine levels	HPOID:0000083	Renal insufficiency	DOID:784	chronic kidney failure	NA	NA	EFOID:0003884	chronic kidney disease	Kidney failure	rs9310709-C	Research Support, Non-U.S. Gov't	C	NA
3	56579538	rs6791987	C	T	rs6791987	pha003069	2.82E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs6791987-T	NA	T
3	65132291	rs6445466	C	T	rs6445466	pha003069	6.40E-05	phs000221	phs000501	0.24	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs6445466-C	NA	T
3	70406133	rs805492	C	A	rs805492	pha003069	2.38E-05	phs000221	phs000501	0.3	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs805492-A	NA	C
3	99266337	rs13070584	C	T	rs13070584	20686651	2.00E-06	CKD	1.42	[1.23-1.65]	2,903 Icelandic CKD cases; 35,818 Icelandic controls; 22,256 Icelandic subjects with serum creatinine	Icelandic(60977)	ALL(60977)	EUR(60977)	ALL(60977)	Chronic kidney disease and serum creatinine levels	HPOID:0000083	Renal insufficiency	DOID:784	chronic kidney failure	NA	NA	EFOID:0003884	chronic kidney disease	Kidney failure	rs13070584-T	Research Support, Non-U.S. Gov't	C	NA
3	106446981	rs2895316	T	C	rs2895316	pha003069	3.79E-05	phs000221	phs000501	0.26	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2895316-C	NA	T
3	121723700	rs12489988	G	A	rs12489988	20222955	4.40E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
3	141733417	rs6781340	G	T	rs6781340	21931561	2.10E-04	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
3	141807137	rs347685	C	A	rs347685	20383146	3.00E-11	eGFRcrea	1.09	[0.007-0.011] unit increase	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs347685-C	NA	C	TFDP2
3	141807137	rs347685	C	A	rs347685	22479191	4.96E-09	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	151381828	rs7624285	T	C	rs7624285	pha003069	2.19E-05	phs000221	phs000501	0.19	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7624285-C	NA	C
3	177920208	rs7653036	G	A	rs7653036	pha003069	6.15E-05	phs000221	phs000501	0.16	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7653036-G	NA	A
3	177970694	rs6808703	T	C	rs6808703	pha003069	5.19E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs6808703-T	NA	C
3	187218336	rs9846911	A	G	rs9846911	23539754	0.0000045	NA	NA	NA	252 Japanese ancestry cases; 249 Japanese ancestry controls	Japanese(501)	ALL(501)	ASN(501)	ALL(501)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, Non-U.S. Gov't	A	NA
4	4252956	rs2980098	A	G	rs2980098	24351856	1.22E-04	NA	1.61	NA	301 Sinhalese Sri Lankan ancestry cases; 276 Sinhalese Sri Lankan ancestry controls	Sinhalese(577)	ALL(577)	SAN(577)	ALL(577)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs2980098-A	Research Support, Non-U.S. Gov't	T	NA
4	47291135	rs4396966	T	C	rs4396966	pha003069	5.55E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4396966-T	NA	T
4	57652380	rs2008139	G	A	rs2008139	pha003069	2.46E-08	phs000221	phs000501	0.38	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2008139-A	NA	A
4	77360431	rs9992101	G	A	rs9992101	20383145	6.00E-09	NA	NA	NA	23,812 European descent individuals	European(23812)	ALL(23812)	EUR(23812)	ALL(23812)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	NA
4	77368847	rs17319721	G	A	rs17319721	20383146	1.00E-19	eGFRcrea	NA	NA	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs17319721-A	NA	G	SHROOM3
4	77368847	rs17319721	G	A	rs17319721	22479191	1.53E-21	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	93318804	rs13122471	G	A	rs13122471	pha003069	8.91E-05	phs000221	phs000501	0.33	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs13122471-A	NA	G
4	103461559	rs4648006	C	T	rs4648006	21931561	1.06E-05	Chronic kidney disease	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
4	111799417	rs6843250	T	G	rs6843250	pha003069	2.25E-05	phs000221	phs000501	0.23	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs6843250-G	NA	G
4	112424765	rs10027375	C	T	rs10027375	pha003069	4.47E-05	phs000221	phs000501	0.27	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs10027375-T	NA	C
4	112432021	rs10002279	T	G	rs10002279	pha003069	5.81E-05	phs000221	phs000501	0.27	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs10002279-G	NA	T
4	113339161	rs6829461	G	T	rs6829461	23539754	0.0000061	NA	NA	NA	252 Japanese ancestry cases; 249 Japanese ancestry controls	Japanese(501)	ALL(501)	ASN(501)	ALL(501)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, Non-U.S. Gov't	G	ALPK1
4	130490140	rs11935537	C	G	rs11935537	22479191	1.50E-06	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	182786746	rs2063955	A	G	rs2063955	pha003069	5.92E-05	phs000221	phs000501	0.34	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2063955-A	NA	G
4	183131995	rs17235597	A	G	rs17235597	pha003069	2.18E-06	phs000221	phs000501	0.22	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs17235597-G	NA	A
4	183132796	rs2726806	G	A	rs2726806	pha003069	4.18E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2726806-G	NA	A
4	183134367	rs17235716	A	G	rs17235716	pha003069	1.48E-06	phs000221	phs000501	0.25	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs17235716-G	NA	A
4	183166469	rs7696796	G	A	rs7696796	pha003069	7.37E-05	phs000221	phs000501	0.19	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7696796-A	NA	A
5	31305265	rs2287581	C	T	rs2287581	pha003069	2.32E-05	phs000221	phs000501	0.33	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2287581-T	NA	G
5	31335274	rs518451	T	C	rs518451	pha003069	7.42E-05	phs000221	phs000501	0.3	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs518451-C	NA	T
5	31352576	rs7733250	A	C	rs7733250	pha003069	2.62E-05	phs000221	phs000501	0.29	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7733250-C	NA	A
5	33114638	rs6894272	C	T	rs6894272	pha003069	9.94E-05	phs000221	phs000501	0.31	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs6894272-T	NA	C
5	39397132	rs11959928	T	A	rs11959928	20383146	1.00E-07	eGFRcrea	0.01	[0.007-0.011] ml/min/1.73 m2 decrease	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs11959928-A	NA	T	DAB2
5	39397132	rs11959928	T	A	rs11959928	22479191	5.19E-13	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	45197779	rs10941694	G	A	rs10941694	20686651	9.00E-06	CKD	1.35	[1.19-1.56]	2,903 Icelandic CKD cases; 35,818 Icelandic controls; 22,256 Icelandic subjects with serum creatinine	Icelandic(60977)	ALL(60977)	EUR(60977)	ALL(60977)	Chronic kidney disease and serum creatinine levels	HPOID:0000083	Renal insufficiency	DOID:784	chronic kidney failure	NA	NA	EFOID:0003884	chronic kidney disease	Kidney failure	rs10941694-A	Research Support, Non-U.S. Gov't	G	NA
5	58399201	rs6865647	A	G	rs6865647	21931561	1.49E-07	Serum cystatin c estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
5	61563586	rs1995782	G	A	rs1995782	pha003069	1.38E-05	phs000221	phs000501	0.18	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs1995782-G	NA	G
5	61569169	rs12659814	T	C	rs12659814	pha003069	1.02E-05	phs000221	phs000501	0.18	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs12659814-T	NA	T
5	61719506	rs152186	A	G	rs152186	pha003069	8.93E-05	phs000221	phs000501	0.03	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs152186-T	NA	A
5	61871009	rs10058598	A	G	rs10058598	pha003069	9.49E-05	phs000221	phs000501	0.16	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs10058598-G	NA	A
5	76903692	rs3933483	T	C	rs3933483	pha003069	1.53E-05	phs000221	phs000501	0.28	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs3933483-C	NA	C
5	81883470	rs1847052	T	C	rs1847052	pha003069	8.60E-05	phs000221	phs000501	0.2	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs1847052-C	NA	A
5	118036547	rs10068737	T	C	rs10068737	22479191	8.70E-07	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	128232901	rs6873372	C	T	rs6873372	pha003069	5.54E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs6873372-T	NA	C
5	154648174	rs4958401	T	G	rs4958401	pha003069	9.07E-05	phs000221	phs000501	0.19	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4958401-G	NA	G
5	165514755	rs13184263	G	T	rs13184263	pha003069	7.24E-05	phs000221	phs000501	0.21	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs13184263-G	NA	T
5	165516543	rs2644732	A	G	rs2644732	pha003069	8.18E-05	phs000221	phs000501	0.2	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2644732-A	NA	C
5	165518937	rs2644731	A	G	rs2644731	pha003069	8.37E-05	phs000221	phs000501	0.2	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2644731-A	NA	T
5	166373903	rs244436	G	T	rs244436	20222955	4.70E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
5	173045602	rs258873	T	G	rs258873	20222955	3.90E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
5	176817636	rs6420094	A	G	rs6420094	20383146	1.00E-14	eGFRcrea	0.01	[0.007-0.015] unit decrease	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs6420094-G	NA	G	SLC34A1
5	176817636	rs6420094	A	G	rs6420094	22479191	5.75E-14	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	178103348	rs10076133	G	A	rs10076133	pha003069	3.91E-05	phs000221	phs000501	0.31	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs10076133-A	NA	A
6	4012929	rs10458166	T	C	rs10458166	pha003069	2.37E-05	phs000221	phs000501	0.23	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs10458166-C	NA	T
6	4069133	rs10485172	T	A,C	rs10485172	pha003069	9.41E-05	phs000221	phs000501	0.24	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs10485172-C	NA	A
6	12841306	rs3945322	G	A	rs3945322	pha003069	7.38E-05	phs000221	phs000501	0.23	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs3945322-A	NA	A
6	12848969	rs9296486	T	G	rs9296486	pha003069	5.44E-05	phs000221	phs000501	0.23	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs9296486-G	NA	T
6	12856827	rs9395185	A	G	rs9395185	pha003069	5.71E-05	phs000221	phs000501	0.23	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs9395185-G	NA	G,A
6	29773852	rs9258447	C	T	rs9258447	pha003069	4.68E-05	phs000221	phs000501	0.28	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs9258447-T	NA	C
6	33094869	rs3129274	C	T	rs3129274	pha003069	1.16E-05	phs000221	phs000501	0.19	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs3129274-C	NA	A
6	33127987	rs4713614	C	A	rs4713614	pha003069	8.41E-05	phs000221	phs000501	0.16	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4713614-C	NA	C
6	33136145	rs986521	G	A	rs986521	pha003069	5.92E-05	phs000221	phs000501	0.08	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs986521-C	NA	T
6	33144373	rs2855425	G	A	rs2855425	pha003069	4.42E-05	phs000221	phs000501	0.18	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2855425-G	NA	T
6	33163451	rs6531	G	A	rs6531	pha003069	6.88E-05	phs000221	phs000501	0.09	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs6531-G	NA	C
6	33185918	rs213212	C	A	rs213212	pha003069	7.76E-05	phs000221	phs000501	0.04	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs213212-A	NA	T
6	34069062	rs3887555	T	C	rs3887555	pha003069	9.05E-05	phs000221	phs000501	0.16	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs3887555-T	NA	G
6	34072561	rs7763695	T	C	rs7763695	pha003069	2.24E-05	phs000221	phs000501	0.18	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7763695-T	NA	T
6	43806609	rs881858	G	A	rs881858	20383146	9.00E-14	eGFRcrea	1.08	[0.007-0.015] unit increase	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs881858-G	NA	G	NA
6	43806609	rs881858	G	A	rs881858	22479191	1.60E-10	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	43810974	rs9369425	G	A	rs9369425	21931561	1.18E-06	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
6	43890856	rs1750571	G	A	rs1750571	21931561	5.00E-04	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
6	90032942	rs2064831	T	C	rs2064831	20222955	7.20E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
6	90043137	rs1998576	G	A	rs1998576	20222955	8.60E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
6	101714615	rs406541	T	G	rs406541	pha003069	5.30E-05	phs000221	phs000501	0.19	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs406541-G	NA	C
6	104760123	rs13213851	A	G	rs13213851	21931561	1.86E-06	Urinary albumin-to-creatinine ratio	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
6	108940280	rs7341233	T	C	rs7341233	pha003069	7.07E-05	phs000221	phs000501	0.26	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7341233-C	NA	C
6	134546685	rs1009840	G	A	rs1009840	21931561	2.62E-07	Albuminuria	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
6	134546685	rs1009840	G	A	rs1009840	21931561	2.62E-07	Microalbuminuria	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
6	155953526	rs9322528	C	T	rs9322528	pha003069	8.64E-05	phs000221	phs000501	0.16	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs9322528-T	NA	C
6	155966676	rs12211057	A	C	rs12211057	pha003069	3.86E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs12211057-C	NA	A
6	155969648	rs9371907	G	A	rs9371907	pha003069	6.87E-05	phs000221	phs000501	0.16	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs9371907-G	NA	A
6	156050029	rs4256444	C	T	rs4256444	pha003069	1.82E-05	phs000221	phs000501	0.18	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4256444-T	NA	C
6	159825449	rs2880072	G	A	rs2880072	21931561	2.98E-07	Urinary albumin-to-creatinine ratio	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
6	159825449	rs2880072	G	A	rs2880072	21931561	4.90E-05	Microalbuminuria	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
6	160668389	rs2279463	A	G	rs2279463	20383146	6.00E-12	eGFRcrea	0.01	[0.009-0.017] unit decrease	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs2279463-G	NA	T	SLC22A2
6	160668389	rs2279463	A	G	rs2279463	22479191	1.10E-11	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	160676216	rs3798156	C	T	rs3798156	21931561	1.20E-06	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
6	160676216	rs3798156	C	T	rs3798156	21931561	2.30E-04	Estimated glomerular filtration rate (eGFR) by serum creatinine in non-diabetics	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
6	160676216	rs3798156	C	T	rs3798156	21931561	2.30E-04	Serum creatinine estimated glomerular filtration rate (eGFR) (no diabetes)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
6	160681393	rs3127573	A	G	rs3127573	20383145	7.00E-10	NA	1.1	[0.8-1.4] % increase	23,812 European descent individuals	European(23812)	ALL(23812)	EUR(23812)	ALL(23812)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs3127573-G	NA
6	160686668	rs316029	T	C	rs316029	21931561	2.60E-07	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
6	165425517	rs1322199	G	A	rs1322199	22479191	8.90E-06	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	54598782	rs500456	A	G	rs500456	22479191	1.00E-06	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	77416439	rs6465825	T	C	rs6465825	20383146	2.00E-09	eGFRcrea	0.01	[0.006-0.01] ml/min/1.73 m2 decrease]	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs6465825-C	NA	T	NA
7	77416439	rs6465825	T	C	rs6465825	22479191	2.05E-08	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	77636954	rs6973213	C	A	rs6973213	21931561	2.75E-04	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
7	80050033	rs7784820	A	G	rs7784820	21931561	5.30E-07	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
7	81561257	rs1229487	T	G	rs1229487	20222955	7.00E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
7	111311611	rs870668	A	G	rs870668	pha003069	6.58E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs870668-A	NA	G
7	111314282	rs12538300	C	T	rs12538300	pha003069	5.54E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs12538300-C	NA	C
7	121949318	rs1443753	T	C	rs1443753	pha003069	9.27E-05	phs000221	phs000501	0.16	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs1443753-T	NA	T
7	151407801	rs7805747	G	A	rs7805747	20383146	4.00E-12	CKD	1.18	[1.12-1.25]	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs7805747-A	NA	G	PRKAG2
7	151407801	rs7805747	G	A	rs7805747	22479191	2.72E-13	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
8	10095707	rs7842910	A	G	rs7842910	pha003069	4.75E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7842910-G	NA	G
8	17338423	rs11778372	G	T	rs11778372	pha003069	5.46E-05	phs000221	phs000501	0.18	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs11778372-T	NA	G
8	23751151	rs10109414	C	T	rs10109414	20383146	1.00E-08	eGFRcrea	NA	NA	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs10109414-T	NA	C	NA
8	23751151	rs10109414	C	T	rs10109414	22479191	2.08E-09	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
8	69162031	rs1608757	C	T	rs1608757	pha003069	9.33E-05	phs000221	phs000501	0.26	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs1608757-T	NA	G
8	72844334	rs9298190	T	C	rs9298190	19929986	1.60E-05	End-stage renal disease in type 1 diabetes	NA	NA	547 European ancestry cases; 549 European ancestry controls	European(1096)	ALL(1096)	EUR(1096)	ALL(1096)	End-stage renal disease	HPOID:0003774	Stage 5 chronic kidney disease	DOID:783	end stage renal failure	D007674	Kidney Diseases	NA	NA	Kidney failure	NA	NA	T	LOC100132891
8	79756591	rs2887502	C	T	rs2887502	pha003069	7.58E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2887502-C	NA	T
8	96486682	rs1500896	G	A	rs1500896	22479191	4.60E-07	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
8	99553256	rs7011216	T	C	rs7011216	pha003069	6.39E-05	phs000221	phs000501	0.35	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7011216-T	NA	C
8	128460878	rs7841228	A	G	rs7841228	pha003069	3.47E-05	phs000221	phs000501	0.19	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7841228-A	NA	G
8	129072161	rs2648875	G	A	rs2648875	17395743	2.00E-06	NA	2.97	[1.90-4.65]	105 cases; 102 controls	NOPOP(207)	ALL(207)	NOPOP(207)	ALL(207)	End-stage renal disease	HPOID:0003774	Stage 5 chronic kidney disease	DOID:783	end stage renal failure	D007674	Kidney Diseases	NA	NA	Kidney failure	rs2648875-A	Research Support, Non-U.S. Gov't	Research Support, N.I.H., Intramural	A
8	131118658	rs4639572	T	C	rs4639572	20222955	4.20E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
8	140532313	rs11778126	C	T	rs11778126	pha003069	1.13E-05	phs000221	phs000501	0.22	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs11778126-T	NA	C
8	140535461	rs6993113	G	A	rs6993113	pha003069	1.19E-05	phs000221	phs000501	0.22	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs6993113-A	NA	A
8	140575658	rs4736281	G	A	rs4736281	pha003069	1.36E-05	phs000221	phs000501	0.22	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4736281-A	NA	G
9	17621965	rs1555422	A	C	rs1555422	pha003069	9.20E-05	phs000221	phs000501	0.18	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs1555422-C	NA	A
9	25294701	rs4977974	T	C	rs4977974	pha003069	5.92E-05	phs000221	phs000501	0.19	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4977974-C	NA	T
9	71433212	rs1556751	G	A	rs1556751	21931561	2.00E-04	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
9	71434707	rs4744712	A	C	rs4744712	20383146	8.00E-14	eGFRcrea	0.01	[0.008-0.016] unit decrease	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs4744712-A	NA	A	PIP5K1B
9	71434707	rs4744712	A	C	rs4744712	21931561	3.00E-04	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
9	71434707	rs4744712	A	C	rs4744712	22479191	7.67E-11	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	81394337	rs7849146	G	T	rs7849146	pha003069	9.83E-05	phs000221	phs000501	0.16	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7849146-T	NA	T
9	107552924	rs4149333	A	G	rs4149333	22479191	5.30E-06	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	115167146	rs4978489	T	C	rs4978489	pha003069	1.51E-06	phs000221	phs000501	0.23	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4978489-C	NA	T
9	115205042	rs10817344	T	G	rs10817344	pha003069	4.96E-07	phs000221	phs000501	0.23	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs10817344-T	NA	G
9	115213702	rs16916995	G	A	rs16916995	pha003069	7.39E-07	phs000221	phs000501	0.24	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs16916995-A	NA	G
9	115289605	rs4979128	T	C	rs4979128	pha003069	2.96E-06	phs000221	phs000501	0.22	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4979128-C	NA	T
9	115320787	rs3983387	T	C	rs3983387	pha003069	8.09E-06	phs000221	phs000501	0.21	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs3983387-C	NA	T
9	115347088	rs2593684	G	A	rs2593684	pha003069	2.15E-05	phs000221	phs000501	0.2	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2593684-A	NA	G
9	115359049	rs2676624	T	C	rs2676624	pha003069	5.30E-06	phs000221	phs000501	0.21	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2676624-C	NA	T
9	127643946	rs2304957	A	G	rs2304957	pha003069	8.78E-05	phs000221	phs000501	0.19	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2304957-G	NA	T
9	128860704	rs2080558	A	C	rs2080558	20222955	6.60E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
9	135051942	rs7851167	C	A	rs7851167	pha003069	1.28E-05	phs000221	phs000501	0.22	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7851167-A	NA	A
9	135053756	rs7039329	C	T	rs7039329	pha003069	1.53E-05	phs000221	phs000501	0.21	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7039329-T	NA	T
9	135055814	rs10116759	A	C	rs10116759	pha003069	7.71E-05	phs000221	phs000501	0.19	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs10116759-C	NA	A
10	1156165	rs10794720	T	C	rs10794720	20383146	1.00E-08	eGFRcrea	0.01	[0.010-0.018] ml/min/1.73 m2 decrease	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs10794720-T	NA	C	WDR37
10	1156165	rs10794720	T	C	rs10794720	22479191	4.96E-08	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
10	4496292	rs1751295	G	A	rs1751295	pha003069	6.44E-05	phs000221	phs000501	0.26	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs1751295-A	NA	G
10	14151277	rs17154656	A	C	rs17154656	pha003069	7.78E-05	phs000221	phs000501	0.36	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs17154656-C	NA	C
10	71916461	rs9971029	G	A	rs9971029	pha003069	9.20E-05	phs000221	phs000501	0.16	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs9971029-A	NA	G
10	80923862	rs1749824	C	A	rs1749824	19929986	8.10E-05	End-stage renal disease in type 1 diabetes	NA	NA	547 European ancestry cases; 549 European ancestry controls	European(1096)	ALL(1096)	EUR(1096)	ALL(1096)	End-stage renal disease	HPOID:0003774	Stage 5 chronic kidney disease	DOID:783	end stage renal failure	D007674	Kidney Diseases	NA	NA	Kidney failure	NA	NA	G	ZMIZ1
10	89950581	rs868872	C	T	rs868872	pha003069	6.42E-05	phs000221	phs000501	0.22	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs868872-T	NA	G
10	122805547	rs7911360	G	A	rs7911360	22479191	7.00E-06	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
11	2798305	rs81204	T	C	rs81204	21931561	3.60E-04	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
11	2845082	rs7111394	T	C	rs7111394	21931561	3.61E-06	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
11	30760335	rs3925584	T	C	rs3925584	22479191	8.00E-18	NA	0.01	[0.0057-0.0093] unit decrease	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
11	33667333	rs1033543	A	G	rs1033543	pha003069	8.49E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs1033543-A	NA	C
11	36472800	rs3740958	A	G	rs3740958	pha003069	8.01E-06	phs000221	phs000501	0.28	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs3740958-G	NA	T
11	65506822	rs4014195	C	G	rs4014195	20383146	1.00E-07	eGFRcrea	0.01	[0.006-0.010] ml/min/1.73 m2 decrease	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs4014195-G	NA	C	NA
11	70433687	rs7945862	A	G	rs7945862	pha003069	4.68E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7945862-A	NA	G
11	73517259	rs11235911	A	G	rs11235911	pha003069	9.50E-05	phs000221	phs000501	0.24	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs11235911-G	NA	A
11	73538698	rs7104794	T	G	rs7104794	pha003069	5.29E-05	phs000221	phs000501	0.25	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7104794-G	NA	T
11	79003851	rs487345	C	T	rs487345	20222955	9.60E-06	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
11	126293285	rs752805	A	T	rs752805	22479191	1.60E-06	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
11	131690566	rs483097	T	C	rs483097	20222955	5.80E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
11	132779393	rs2725466	A	G	rs2725466	pha003069	9.69E-05	phs000221	phs000501	0.16	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2725466-G	NA	G
11	133776948	rs329674	A	G	rs329674	pha003069	3.60E-05	phs000221	phs000501	0.2	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs329674-A	NA	G
11	134903460	rs12575381	G	A	rs12575381	21931561	9.97E-07	Chronic kidney disease	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
12	349298	rs10774021	C	T	rs10774021	20383146	1.00E-09	eGFRcrea	1.05	[0.006-0.010] ml/min/1.73 m2 increase	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs10774021-C	NA	T	SLC6A13
12	349298	rs10774021	C	T	rs10774021	22479191	4.67E-07	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
12	2560116	rs4765687	A	G	rs4765687	pha003069	2.01E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4765687-G	NA	A
12	10748314	rs2168749	C	T	rs2168749	19929986	6.00E-04	End-stage renal disease in type 1 diabetes	NA	NA	547 European ancestry cases; 549 European ancestry controls	European(1096)	ALL(1096)	EUR(1096)	ALL(1096)	End-stage renal disease	HPOID:0003774	Stage 5 chronic kidney disease	DOID:783	end stage renal failure	D007674	Kidney Diseases	NA	NA	Kidney failure	NA	NA	G	NA
12	14409528	rs12300043	G	A	rs12300043	pha003069	3.35E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs12300043-G	NA	G
12	41247933	rs312272	T	C	rs312272	pha003069	8.11E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs312272-C	NA	A
12	41299039	rs4768319	A	C	rs4768319	pha003069	4.25E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4768319-A	NA	C
12	41311466	rs11179042	C	T	rs11179042	pha003069	7.67E-05	phs000221	phs000501	0.16	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs11179042-T	NA	C
12	41324876	rs1372542	C	T	rs1372542	pha003069	8.06E-05	phs000221	phs000501	0.16	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs1372542-T	NA	G
12	41330531	rs2289522	T	C	rs2289522	pha003069	7.22E-05	phs000221	phs000501	0.16	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2289522-C	NA	A
12	41347940	rs10879417	T	C	rs10879417	pha003069	4.56E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs10879417-C	NA	T
12	41996155	rs1390373	C	T	rs1390373	pha003069	3.32E-06	phs000221	phs000501	0.21	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs1390373-T	NA	A
12	41997375	rs4378453	C	A	rs4378453	pha003069	6.35E-06	phs000221	phs000501	0.2	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4378453-A	NA	A
12	66749879	rs1168357	T	C	rs1168357	22479191	2.40E-07	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
12	68077188	rs6581768	A	G	rs6581768	21931561	3.00E-07	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
12	79481297	rs10506807	T	C	rs10506807	20222955	7.00E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
12	79481371	rs12300068	G	A	rs12300068	20222955	5.70E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
12	79505136	rs11112829	T	C	rs11112829	20222955	7.60E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
12	98934105	rs4762495	C	T	rs4762495	19929986	5.00E-04	End-stage renal disease in type 1 diabetes	NA	NA	547 European ancestry cases; 549 European ancestry controls	European(1096)	ALL(1096)	EUR(1096)	ALL(1096)	End-stage renal disease	HPOID:0003774	Stage 5 chronic kidney disease	DOID:783	end stage renal failure	D007674	Kidney Diseases	NA	NA	Kidney failure	NA	NA	G	TMPO
12	112007756	rs653178	C	T	rs653178	20383146	4.00E-11	eGFRcys	0.01	[0.009-0.017] unit increase	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs653178-T	NA	A	ATXN2
13	67382987	rs7139567	T	C	rs7139567	pha003069	9.26E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7139567-C	NA	T
13	72347696	rs626277	A	C	rs626277	20383146	3.00E-11	eGFRcrea	0.01	[0.007-0.011] unit increase	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs626277-C	NA	C	DACH1
13	72347696	rs626277	A	C	rs626277	22479191	2.85E-10	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
13	110259068	rs1411765	A	G	rs1411765	19929986	1.00E-04	End-stage renal disease in type 1 diabetes	NA	NA	547 European ancestry cases; 549 European ancestry controls	European(1096)	ALL(1096)	EUR(1096)	ALL(1096)	End-stage renal disease	HPOID:0003774	Stage 5 chronic kidney disease	DOID:783	end stage renal failure	D007674	Kidney Diseases	NA	NA	Kidney failure	NA	NA	C	NA
14	102586213	rs7157967	T	C	rs7157967	20222955	7.90E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
14	102687856	rs11160674	T	C	rs11160674	20222955	1.60E-05	NA	NA	NA	4,006 European individuals	European(4006)	ALL(4006)	EUR(4006)	ALL(4006)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	NA	Meta-Analysis
15	41401550	rs2928148	G	A	rs2928148	22479191	4.04E-08	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
15	45641225	rs2453533	C	A	rs2453533	20383146	5.00E-22	eGFRcrea	NA	NA	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	NA	A	NA
15	45641225	rs2453533	C	A	rs2453533	22479191	4.03E-22	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
15	45644709	rs1153859	C	T	rs1153859	21931561	1.08E-04	Estimated glomerular filtration rate (eGFR) by serum creatinine in non-hypertensives	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
15	45644709	rs1153859	C	T	rs1153859	21931561	1.08E-04	Serum creatinine estimated glomerular filtration rate (eGFR) (no hypertension)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
15	45644709	rs1153859	C	T	rs1153859	21931561	2.20E-04	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
15	53881945	rs16966247	G	C	rs16966247	21931561	2.00E-04	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
15	53946593	rs491567	A	C	rs491567	20383146	3.00E-13	eGFRcrea	0.01	[0.005-0.013] unit increase	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs491567-C	NA	G	WDR72
15	53946593	rs491567	A	C	rs491567	22479191	3.54E-11	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
15	76158983	rs1394125	G	A	rs1394125	20383146	3.00E-17	eGFRcrea	0.01	[0.007-0.011] unit decrease	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs1394125-A	NA	G,A	UBE2Q2
15	76158983	rs1394125	G	A	rs1394125	22479191	7.42E-11	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
15	76251848	rs2454472	A	T	rs2454472	21931561	9.00E-04	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
15	80563203	rs11856226	G	T	rs11856226	pha003069	3.55E-05	phs000221	phs000501	0.19	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs11856226-T	NA	G
15	89192873	rs4932187	T	C	rs4932187	pha003069	9.83E-05	phs000221	phs000501	0.22	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4932187-T	NA	C
16	7633995	rs6500988	T	C	rs6500988	pha003069	4.31E-05	phs000221	phs000501	0.33	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs6500988-T	NA	C
16	13643974	rs8056716	G	A	rs8056716	pha003069	8.90E-05	phs000221	phs000501	0.16	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs8056716-A	NA	G
16	20364588	rs4293393	A	G	rs4293393	20686651	4.00E-10	CKD	1.25	[1.17-1.35]	2,903 Icelandic CKD cases; 35,818 Icelandic controls; 22,256 Icelandic subjects with serum creatinine	Icelandic(60977)	ALL(60977)	EUR(60977)	ALL(60977)	Chronic kidney disease and serum Creatinine levels	HPOID:0000083	Renal insufficiency	DOID:784	chronic kidney failure	NA	NA	EFOID:0003884	chronic kidney disease	Kidney failure	rs4293393-T	Research Support, Non-U.S. Gov't	T	UMOD
16	20367645	rs12922822	C	T	rs12922822	21931561	6.48E-08	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
16	20367690	rs12917707	G	T	rs12917707	20383146	1.00E-20	eGFRcrea	NA	NA	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs12917707-T	NA	G	NA
16	20367690	rs12917707	G	T	rs12917707	22479191	2.16E-23	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
16	27413566	rs2189521	C	T	rs2189521	pha003069	8.75E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2189521-C	NA	G
16	54490303	rs1861352	G	A	rs1861352	pha003069	1.02E-05	phs000221	phs000501	0.21	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs1861352-A	NA	G
16	54492183	rs12447674	A	G	rs12447674	pha003069	4.10E-05	phs000221	phs000501	0.2	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs12447674-G	NA	A
16	59433491	rs6500035	A	G	rs6500035	pha003069	1.39E-05	phs000221	phs000501	0.19	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs6500035-A	NA	G
16	59434042	rs8051036	C	T	rs8051036	pha003069	1.39E-05	phs000221	phs000501	0.19	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs8051036-C	NA	T
16	59464031	rs2048320	C	T	rs2048320	pha003069	5.77E-05	phs000221	phs000501	0.18	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2048320-C	NA	T
17	19438321	rs2453580	T	C	rs2453580	22479191	5.16E-08	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
17	37483599	rs9944411	T	C	rs9944411	21931561	8.37E-07	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
17	37631924	rs11078903	G	A	rs11078903	22479191	3.07E-09	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
17	49886052	rs1501255	C	T	rs1501255	pha003069	8.48E-05	phs000221	phs000501	0.17	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs1501255-C	NA	A
17	59449636	rs11650989	G	A	rs11650989	21931561	5.80E-04	Serum creatinine estimated glomerular filtration rate (eGFR)	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
17	59456589	rs9895661	C	T	rs9895661	20383146	1.00E-15	eGFRcrea	0.01	[0.007-0.015] unit decrease	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs9895661-C	NA	T	BCAS3
17	59456589	rs9895661	C	T	rs9895661	22479191	4.85E-08	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
17	59483766	rs8068318	C	T	rs8068318	20383145	3.00E-10	NA	0.8	[0.6-1.0] % increase	23,812 European descent individuals	European(23812)	ALL(23812)	EUR(23812)	ALL(23812)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs8068318-G	NA
17	74696760	rs1005645	T	C	rs1005645	pha003069	2.18E-05	phs000221	phs000501	0.33	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs1005645-T	NA	G
18	5366458	rs7236529	C	T	rs7236529	pha003069	9.28E-05	phs000221	phs000501	0.16	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7236529-T	NA	T,C
18	13199302	rs2155869	T	C	rs2155869	pha003069	5.36E-06	phs000221	phs000501	0.26	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs2155869-T	NA	C
18	13207252	rs4797739	A	G	rs4797739	pha003069	1.67E-05	phs000221	phs000501	0.23	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4797739-A	NA	A
18	25621366	rs17446008	C	A	rs17446008	22479191	1.10E-06	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
18	37882901	rs12327116	G	A	rs12327116	pha003069	2.75E-05	phs000221	phs000501	0.37	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs12327116-A	NA	G
18	67276722	rs4555246	G	A,T	rs4555246	21931561	1.71E-05	Urinary albumin-to-creatinine ratio without diabetes	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
18	67276722	rs4555246	G	A,T	rs4555246	21931561	3.08E-05	Urinary albumin-to-creatinine ratio without hypertension	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
18	67276722	rs4555246	G	A,T	rs4555246	21931561	5.33E-07	Urinary albumin-to-creatinine ratio	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
18	67276722	rs571461077	G	GAAAT	rs4555246	21931561	1.71E-05	Urinary albumin-to-creatinine ratio without diabetes	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
18	67276722	rs571461077	G	GAAAT	rs4555246	21931561	3.08E-05	Urinary albumin-to-creatinine ratio without hypertension	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
18	67276722	rs571461077	G	GAAAT	rs4555246	21931561	5.33E-07	Urinary albumin-to-creatinine ratio	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
18	67276722	rs58206678	G	GAAAT,GAAATAAATAAATAAAT	rs4555246	21931561	1.71E-05	Urinary albumin-to-creatinine ratio without diabetes	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
18	67276722	rs58206678	G	GAAAT,GAAATAAATAAATAAAT	rs4555246	21931561	3.08E-05	Urinary albumin-to-creatinine ratio without hypertension	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
18	67276722	rs58206678	G	GAAAT,GAAATAAATAAATAAAT	rs4555246	21931561	5.33E-07	Urinary albumin-to-creatinine ratio	NA	NA	8110 African ancestry samples	African(8110)	ALL(8110)	AFR(8110)	ALL(8110)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, N.I.H., Intramural
18	74940312	rs4890812	C	T	rs4890812	pha003069	9.22E-05	phs000221	phs000501	0.16	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4890812-T	NA	C
19	33356891	rs12460876	T	C	rs12460876	20383146	3.00E-15	eGFRcrea	0.01	[0.006-0.01] unit increase	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs12460876-C	NA	T	SLC7A9
19	33356891	rs12460876	T	C	rs12460876	22479191	8.63E-11	NA	NA	NA	74,354 European ancestry individuals	European(74354)	ALL(74354)	EUR(74354)	ALL(74354)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
19	33453659	rs4805834	T	C	rs4805834	20383145	5.00E-11	NA	1	[0.7-1.3] % decrease	23,812 European descent individuals	European(23812)	ALL(23812)	EUR(23812)	ALL(23812)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs4805834-A	NA
19	45103698	rs7259313	T	C	rs7259313	pha003069	3.28E-05	phs000221	phs000501	0.19	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs7259313-C	NA	T
20	23612737	rs911119	C	T	rs911119	20383146	2.00E-138	eGFRcys	NA	NA	Up to 67,093 European ancestry individuals	European(67093)	ALL(67093)	EUR(67093)	ALL(67093)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	NA	C	NA
20	45278169	rs1004571	A	G	rs1004571	24351856	1.73E-04	NA	1.63	NA	301 Sinhalese Sri Lankan ancestry cases; 276 Sinhalese Sri Lankan ancestry controls	Sinhalese(577)	ALL(577)	SAN(577)	ALL(577)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs1004571-A	Research Support, Non-U.S. Gov't	G	SLC13A3
20	45288453	rs6066043	G	A	rs6066043	24351856	3.73E-08	NA	2.13	NA	301 Sinhalese Sri Lankan ancestry cases; 276 Sinhalese Sri Lankan ancestry controls	Sinhalese(577)	ALL(577)	SAN(577)	ALL(577)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs6066043-G	Research Support, Non-U.S. Gov't	G	SLC13A3
20	45306928	rs4810537	A	G	rs4810537	24351856	2.67E-04	NA	1.6	NA	301 Sinhalese Sri Lankan ancestry cases; 276 Sinhalese Sri Lankan ancestry controls	Sinhalese(577)	ALL(577)	SAN(577)	ALL(577)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	rs4810537-A	Research Support, Non-U.S. Gov't	G	SLC13A3
20	53325604	rs6068963	G	A	rs6068963	pha003069	6.91E-05	phs000221	phs000501	0.34	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs6068963-A	NA	G
21	43522650	rs220110	C	A,G,T	rs220110	23539754	0.0000085	NA	NA	NA	252 Japanese ancestry cases; 249 Japanese ancestry controls	Japanese(501)	ALL(501)	ASN(501)	ALL(501)	Chronic kidney disease	HPOID:0000077	Abnormality of the kidney	DOID:784	chronic kidney failure	D007676	Kidney Failure, Chronic	EFOID:0004518	chronic kidney disease	Kidney failure	NA	Research Support, Non-U.S. Gov't	T	UMODL1
22	18222263	rs181390	A	G	rs181390	19929986	2.00E-04	End-stage renal disease in type 1 diabetes	NA	NA	547 European ancestry cases; 549 European ancestry controls	European(1096)	ALL(1096)	EUR(1096)	ALL(1096)	End-stage renal disease	HPOID:0003774	Stage 5 chronic kidney disease	DOID:783	end stage renal failure	D007674	Kidney Diseases	NA	NA	Kidney failure	NA	NA	A	BID
22	36616445	rs4821469	T	C	rs4821469	20532800	2.00E-19	NA	2.86	[2.27-3.57]	464 African American cases; 478 African American controls	African American(942)	ALL(942)	AFR(942)	ALL(942)	End-stage renal disease (non-diabetic)	HPOID:0003774	Stage 5 chronic kidney disease	DOID:783	end stage renal failure	D007674	Kidney Diseases	EFOID:0003884	chronic kidney disease	Kidney failure	NA	Research Support, N.I.H., Extramural	Research Support, N.I.H., Intramural	T
22	40552119	rs9611280	G	A	rs9611280	pha003069	9.24E-05	phs000221	phs000501	0.25	NA	NA	ALL(0)	ALL(0)	Creatinine levels	HPOID:0012100	HPOID:0000077	Abnormal circulating creatinine level	Abnormality of the kidney	DOID:784	chronic kidney failure	NA	NA	EFOID:0004518	serum creatinine measurement	Kidney failure	rs9611280-A	NA	G

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:26)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0022661	acetaminophen	D000082	103-90-2	kidney failure, chronic	MESH:D007676	marker/mechanism	11752356
C0022661	allopurinol	D000493	315-30-0	kidney failure, chronic	MESH:D007676	therapeutic	8842764
C0022661	benazepril	C044946	86541-75-5	kidney failure, chronic	MESH:D007676	therapeutic	11867951
C0022661	cidofovir	C059262	113852-37-2	kidney failure, chronic	MESH:D007676	marker/mechanism	10589927
C0022661	ciprofloxacin	D002939	85721-33-1	kidney failure, chronic	MESH:D007676	marker/mechanism	12911170
C0022661	calcitriol	D002117	32222-06-3	kidney failure, chronic	MESH:D007676	therapeutic	15354979
C0022661	enalapril	D004656	75847-73-3	kidney failure, chronic	MESH:D007676	marker/mechanism	2555956
C0022661	enalapril	D004656	75847-73-3	kidney failure, chronic	MESH:D007676	therapeutic	16631587
C0022661	folic acid	D005492	59-30-3	kidney failure, chronic	MESH:D007676	marker/mechanism	4810836
C0022661	foscarnet	D017245	4428-95-9	kidney failure, chronic	MESH:D007676	marker/mechanism	9740173
C0022661	ifosfamide	D007069	3778-73-2	kidney failure, chronic	MESH:D007676	marker/mechanism	15503294
C0022661	indinavir	D019469	150378-17-9	kidney failure, chronic	MESH:D007676	marker/mechanism	17502722
C0022661	indomethacin	D007213	53-86-1	kidney failure, chronic	MESH:D007676	marker/mechanism	6986554
C0022661	lovastatin	D008148	75330-75-5	kidney failure, chronic	MESH:D007676	marker/mechanism	8918723
C0022661	melphalan	D008558	148-82-3	kidney failure, chronic	MESH:D007676	marker/mechanism	4571885
C0022661	mitomycin	D016685	1950/7/7	kidney failure, chronic	MESH:D007676	marker/mechanism	6340628
C0022661	nevirapine	D019829	129618-40-2	kidney failure, chronic	MESH:D007676	marker/mechanism	11263401
C0022661	oxycodone	D010098	76-42-6	kidney failure, chronic	MESH:D007676	marker/mechanism	12203209
C0022661	pirfenidone	C093844	53179-13-8	kidney failure, chronic	MESH:D007676	therapeutic	20006961
C0022661	propylthiouracil	D011441	51-52-5	kidney failure, chronic	MESH:D007676	marker/mechanism	10344375
C0022661	ramipril	D017257	87333-19-5	kidney failure, chronic	MESH:D007676	therapeutic	9851320
C0022661	streptozocin	D013311	18883-66-4	kidney failure, chronic	MESH:D007676	marker/mechanism	6459048
C0022661	sulindac	D013467	38194-50-2	kidney failure, chronic	MESH:D007676	therapeutic	3884224
C0022661	tacrolimus	D016559	109581-93-3	kidney failure, chronic	MESH:D007676	marker/mechanism	10831087
C0022661	tenofovir	D000068698	-	kidney failure, chronic	MESH:D007676	marker/mechanism	17502722
C0022661	zidovudine	D015215	30516-87-1	kidney failure, chronic	MESH:D007676	marker/mechanism	11263401

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)