PedAM

Pediatric Disease Annotations & Medicines


	chronic inflammatory demyelinating polyradiculoneuropathy

Disease ID	633
Disease	chronic inflammatory demyelinating polyradiculoneuropathy
Definition	A slowly progressive autoimmune demyelinating disease of peripheral nerves and nerve roots. Clinical manifestations include weakness and sensory loss in the extremities and enlargement of peripheral nerves. The course may be relapsing-remitting or demonstrate a step-wise progression. Protein is usually elevated in the spinal fluid and cranial nerves are typically spared. GUILLAIN-BARRE SYNDROME features a relatively rapid progression of disease which distinguishes it from this condition. (Adams et al., Principles of Neurology, 6th ed, p1337)
Synonym	chr inflam polyneuritis chronic inflamm demyelinating polyradiculoneuropathy chronic inflamm polyradiculoneuropathy chronic inflammatory demyelinating polyneuritis chronic inflammatory demyelinating polyneuritis (disorder) chronic inflammatory demyelinating polyneuropathy chronic inflammatory demyelinating polyneuropathy (disorder) chronic inflammatory demyelinating polyradiculoneuropathy (cidp) chronic inflammatory demyelinating polyradiculoneuropathy (disorder) chronic inflammatory polyradiculoneuropathies chronic inflammatory polyradiculoneuropathy chronic inflammatory polyradiculopathies chronic inflammatory polyradiculopathy cidp cidp (chronic inflammatory demyelinating polyneuropathy) cidp - chronic inflammatory demyelinating polyradiculoneuropathy inflamm polyradiculopathy chronic inflammatory polyradiculopathies, chronic inflammatory polyradiculopathy, chronic polyneuropathy, inflammatory demyelinating, chronic polyradiculoneuropathies, chronic inflammatory polyradiculoneuropathy chronic inflamm polyradiculoneuropathy chronic inflamm demyelinating polyradiculoneuropathy, chronic inflammatory polyradiculoneuropathy, chronic inflammatory demyelinating polyradiculoneuropathy, chronic inflammatory demyelinating [disease/finding] polyradiculopathies, chronic inflammatory polyradiculopathy, chronic inflammatory
Orphanet	ORPHANET:2932
DOID	DOID:5213 DOID:2536
ICD10	ICD10CM:G61.81
UMLS	C0393819
MeSH	D020277
SNOMED-CT	SNOMEDCT_US_2016_09_01:444728005;SNOMEDCT_US_2016_09_01:128209004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:27) C0011847 \| diabetes \| 3 C0011849 \| diabetes mellitus \| 2 C0036439 \| scoliosis \| 2 C0017665 \| membranous nephropathy \| 1 C0008312 \| primary biliary cirrhosis \| 1 C0002170 \| alopecia \| 1 C1136085 \| monoclonal gammopathy \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0409974 \| lupus erythematosus \| 1 C0235025 \| motor neuropathy \| 1 C1145670 \| respiratory failure \| 1 C0442874 \| neuropathy \| 1 C0010346 \| crohn's disease \| 1 C0035258 \| restless legs syndrome \| 1 C0241910 \| autoimmune hepatitis \| 1 C1527336 \| sjogren's syndrome \| 1 C0025202 \| melanoma \| 1 C0152025 \| polyneuropathy \| 1 C0026846 \| muscle atrophy \| 1 C0017668 \| focal segmental glomerulosclerosis \| 1 C0023890 \| cirrhosis \| 1 C0008312 \| biliary cirrhosis \| 1 C0040034 \| thrombocytopenia \| 1 C0017658 \| glomerulonephritis \| 1 C0025202 \| malignant melanoma \| 1 C0011603 \| dermatitis \| 1 C0026896 \| myasthenia gravis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:8) 627 \| BDNF \| infer 10462 \| CLEC10A \| infer 6900 \| CNTN2 \| infer 1493 \| CTLA4 \| infer 23095 \| KIF1B \| infer 10718 \| NRG3 \| infer 9047 \| SH2D2A \| infer 6892 \| TAPBP \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:62) 8935 \| SKAP2 \| DISEASES 55359 \| STYK1 \| DISEASES 54332 \| GDAP1 \| DISEASES 973 \| CD79A \| DISEASES 81622 \| UNC93B1 \| DISEASES 3458 \| IFNG \| DISEASES 55907 \| CMAS \| DISEASES 51185 \| CRBN \| DISEASES 9927 \| MFN2 \| DISEASES 7276 \| TTR \| DISEASES 971 \| CD72 \| DISEASES 9172 \| MYOM2 \| DISEASES 941 \| CD80 \| DISEASES 8506 \| CNTNAP1 \| DISEASES 3383 \| ICAM1 \| DISEASES 3827 \| KNG1 \| DISEASES 1737 \| DLAT \| DISEASES 729230 \| CCR2 \| DISEASES 1234 \| CCR5 \| DISEASES 2215 \| FCGR3B \| DISEASES 213 \| ALB \| DISEASES 1230 \| CCR1 \| DISEASES 3627 \| CXCL10 \| DISEASES 2915 \| GRM5 \| DISEASES 5376 \| PMP22 \| DISEASES 5062 \| PAK2 \| DISEASES 80381 \| CD276 \| DISEASES 1272 \| CNTN1 \| DISEASES 3563 \| IL3RA \| DISEASES 126282 \| TNFAIP8L1 \| DISEASES 942 \| CD86 \| DISEASES 342035 \| GLDN \| DISEASES 966 \| CD59 \| DISEASES 3605 \| IL17A \| DISEASES 23114 \| NFASC \| DISEASES 23481 \| PES1 \| DISEASES 100506658 \| OCLN \| DISEASES 3240 \| HP \| DISEASES 337 \| APOA4 \| DISEASES 356 \| FASLG \| DISEASES 2214 \| FCGR3A \| DISEASES 910 \| CD1B \| DISEASES 959 \| CD40LG \| DISEASES 5730 \| PTGDS \| DISEASES 7422 \| VEGFA \| DISEASES 5476 \| CTSA \| DISEASES 4593 \| MUSK \| DISEASES 7133 \| TNFRSF1B \| DISEASES 1676 \| DFFA \| DISEASES 4897 \| NRCAM \| DISEASES 3456 \| IFNB1 \| DISEASES 5277 \| PIGA \| DISEASES 51199 \| NIN \| DISEASES 54476 \| RNF216 \| DISEASES 4099 \| MAG \| DISEASES 9047 \| SH2D2A \| DISEASES 93487 \| MAPK1IP1L \| DISEASES 3676 \| ITGA4 \| DISEASES 23308 \| ICOSLG \| DISEASES 7122 \| CLDN5 \| DISEASES 4908 \| NTF3 \| DISEASES 4359 \| MPZ \| DISEASES
Locus	(Waiting for update.)

Disease ID	633
Disease	chronic inflammatory demyelinating polyradiculoneuropathy
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:23) HP:0000819 \| Diabetes mellitus \| 2 HP:0002650 \| Scoliosis \| 2 HP:0002664 \| Neoplasia \| 2 HP:0002878 \| Respiratory failure \| 1 HP:0002459 \| Dysautonomia \| 1 HP:0006597 \| Paralyzed diaphragm \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0000097 \| focal glomerulosclerosis \| 1 HP:0002613 \| Biliary cirrhosis \| 1 HP:0001596 \| Hair loss \| 1 HP:0003447 \| Axonal loss \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0007418 \| Alopecia totalis \| 1 HP:0001271 \| Polyneuropathy \| 1 HP:0010871 \| Ataxia, sensory \| 1 HP:0000099 \| Glomerular nephritis \| 1 HP:0012578 \| Membranous glomerulonephritis \| 1 HP:0001394 \| Hepatic cirrhosis \| 1 HP:0003202 \| Neurogenic muscle atrophy, especially in the lower limbs \| 1 HP:0007687 \| Unilateral ptosis \| 1 HP:0003473 \| Fatigable weakness \| 1 HP:0002861 \| Melanoma \| 1 HP:0001873 \| Low platelet count \| 1

Disease ID	633
Disease	chronic inflammatory demyelinating polyradiculoneuropathy
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0017658 \| glomerulonephritis \| 1 C0004093 \| weakness \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs397514767	25818314	966	CD59	umls:C0393819	BeFree	The Cys89Tyr mutation in CD59 was clinically manifested in infancy, and associated with chronic hemolysis and relapsing peripheral demyelinating disease resembling recurrent Guillain-Barré syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP).	0.000271442	2015	CD59	11	33710247	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0393819	pregabalin	D000069583	-	polyradiculoneuropathy, chronic inflammatory demyelinating	MESH:D020277	therapeutic	18670249
C0393819	tacrolimus	D016559	109581-93-3	polyradiculoneuropathy, chronic inflammatory demyelinating	MESH:D020277	marker/mechanism	18297634

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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