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PedAM

Pediatric Disease Annotations & Medicines



   chronic graft versus host disease
  

Disease ID 796
Disease chronic graft versus host disease
Definition
A syndrome of immunologically mediated tissue damage that may occur following an allogeneic transplant, and may affect multiple organs with manifestations similar to autoimmune diseases. The onset is usually within three years of transplantation or immunologic manipulation.
Synonym
chronc graft-vs-host dis
chronic graft-versus-host disease
chronic graft-versus-host disease (disorder)
chronic gvhd
graft versus host disease, chronic
gvhd, chronic
Orphanet
ICD10
UMLS
C0867389
SNOMED-CT
Comorbidity
UMLS | Disease | Sentences' Count(Total Sentences:9)
C0037199  |  sinusitis  |  1
C0021843  |  bowel obstruction  |  1
C0023467  |  acute myeloid leukemia  |  1
C0314719  |  dry eye  |  1
C0020541  |  portal hypertension  |  1
C0013238  |  dry eye syndrome  |  1
C0023470  |  myeloid leukemia  |  1
C0023418  |  leukemia  |  1
C0020538  |  hypertension  |  1
Curated Gene(Waiting for update.)
Inferring Gene
Entrez_id | Symbol | Resource(Total Genes:2)
3552  |  IL1A  |  infer
7124  |  TNF  |  infer
Text Mined Gene(Waiting for update.)
Locus(Waiting for update.)
Disease ID 796
Disease chronic graft versus host disease
Integrated Phenotype(Waiting for update.)
Text Mined Phenotype
HPO | Name | Sentences' Count(Total Phenotypes:8)
HP:0000822  |  Hypertension  |  1
HP:0001909  |  Leukemia  |  1
HP:0000246  |  Sinus inflammation  |  1
HP:0012324  |  Myeloid leukemia  |  1
HP:0005214  |  Bowel obstruction  |  1
HP:0001409  |  Portal hypertension  |  1
HP:0004808  |  Acute myelogenous leukemia  |  1
HP:0000217  |  Dry mouth syndrome  |  1
Disease ID 796
Disease chronic graft versus host disease
Manually Symptom
UMLS  | Name(Total Manually Symptoms:6)
C0600502  |  hemostatic disorders
C0314719  |  dry eye
C0043352  |  xerostomia
C0027121  |  myositis
C0023895  |  liver disorders
C0002170  |  alopecia
Text Mined Symptom
UMLS | Name | Sentences' Count(Total Symptoms:1)
C0314719  |  dry eye  |  1
Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)
All Snps(Total Genotypes:9)
snpId pubmedId geneId geneSymbol diseaseId sourceId sentence score Year geneSymbol_dbSNP CHROMOSOME POS REF ALT
rs1131012226464855175PECAM1umls:C0867389BeFreeWe evaluated the association of 4 SNPs in ICAM1 (rs5498), PECAM1 (rs668 and rs1131012) and SELL (rs2229569) genes with acute and chronic graft-versus-host disease (GvHD) and those experiencing transplant-related mortality (TRM) within 1 year among 425 allogeneic HCT recipient-donor pairs.0.0010857672013PECAM11764350416TC
rs124289302162841610673TNFSF13Bumls:C0867389BeFreeIn multivariate analyses, 4 recipient BAFF SNPs (rs16972217 [odds ratio = 2.72, P = .004], rs7993590 [odds ratio = 2.35, P = .011], rs12428930 [odds ratio2.53, P = .008], and rs2893321 [odds ratio = 2.48, P = .009]) were independent predictors of GVHD subtypes, adjusted for conventional predictors of cGVHD.0.0005428842011TNFSF13B;LOC10272434713108287357AC
rs169722172162841610673TNFSF13Bumls:C0867389BeFreeIn multivariate analyses, 4 recipient BAFF SNPs (rs16972217 [odds ratio = 2.72, P = .004], rs7993590 [odds ratio = 2.35, P = .011], rs12428930 [odds ratio2.53, P = .008], and rs2893321 [odds ratio = 2.48, P = .009]) were independent predictors of GVHD subtypes, adjusted for conventional predictors of cGVHD.0.0005428842011TNFSF13B;LOC10272434713108283099CT
rs180541020574454142PARP1umls:C0867389BeFreeOne SNP in PARP1 gene (rs1805410) was associated with a higher risk of chronic GVHD (RR: 1.81, 95% CI: 1.29-2.54, P=0.001).0.0002714422010PARP11226380964TC
rs2229569226464855175PECAM1umls:C0867389BeFreeWe evaluated the association of 4 SNPs in ICAM1 (rs5498), PECAM1 (rs668 and rs1131012) and SELL (rs2229569) genes with acute and chronic graft-versus-host disease (GvHD) and those experiencing transplant-related mortality (TRM) within 1 year among 425 allogeneic HCT recipient-donor pairs.0.0010857672013SELL1169704697GT,A
rs28933212162841610673TNFSF13Bumls:C0867389BeFreeIn multivariate analyses, 4 recipient BAFF SNPs (rs16972217 [odds ratio = 2.72, P = .004], rs7993590 [odds ratio = 2.35, P = .011], rs12428930 [odds ratio2.53, P = .008], and rs2893321 [odds ratio = 2.48, P = .009]) were independent predictors of GVHD subtypes, adjusted for conventional predictors of cGVHD.0.0005428842011TNFSF13B;LOC10272434713108290686AG
rs5498226464855175PECAM1umls:C0867389BeFreeWe evaluated the association of 4 SNPs in ICAM1 (rs5498), PECAM1 (rs668 and rs1131012) and SELL (rs2229569) genes with acute and chronic graft-versus-host disease (GvHD) and those experiencing transplant-related mortality (TRM) within 1 year among 425 allogeneic HCT recipient-donor pairs.0.0010857672013ICAM1;ICAM4;LOC1053722721910285007AG
rs668226464855175PECAM1umls:C0867389BeFreeWe evaluated the association of 4 SNPs in ICAM1 (rs5498), PECAM1 (rs668 and rs1131012) and SELL (rs2229569) genes with acute and chronic graft-versus-host disease (GvHD) and those experiencing transplant-related mortality (TRM) within 1 year among 425 allogeneic HCT recipient-donor pairs.0.0010857672013NANANANANA
rs79935902162841610673TNFSF13Bumls:C0867389BeFreeIn multivariate analyses, 4 recipient BAFF SNPs (rs16972217 [odds ratio = 2.72, P = .004], rs7993590 [odds ratio = 2.35, P = .011], rs12428930 [odds ratio2.53, P = .008], and rs2893321 [odds ratio = 2.48, P = .009]) were independent predictors of GVHD subtypes, adjusted for conventional predictors of cGVHD.0.0005428842011TNFSF13B;LOC10272434713108283554AT
GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)
GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)
Mapped by lexical matching(Total Items:0)
(Waiting for update.)
Mapped by homologous gene(Total Items:0)
(Waiting for update.)
Chemical(Total Drugs:0)
(Waiting for update.)
FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)
FDA labeling changes(Total Drugs:0)
(Waiting for update.)