PedAM

Pediatric Disease Annotations & Medicines


	cholecystitis

Disease ID	707
Disease	cholecystitis
Definition	Inflammation of the GALLBLADDER; generally caused by impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, or other diseases.
Synonym	cholecystitis (disorder) cholecystitis [disease/finding] cholecystitis nos cholecystitis nos (disorder) cholecystitis, nos cholecystitis, unspecified gall bladder inflammation gallbladder inflamm gallbladder inflammation inflamed gallbladder inflammation gall bladder inflammation, gallbladder
DOID	DOID:1949
ICD10	ICD10CM:K81.9
UMLS	C0008325
MeSH	D002764
SNOMED-CT	SNOMEDCT_US_2016_09_01:76581006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:111) C0008350 \| cholelithiasis \| 22 C0008350 \| gallstones \| 14 C0008311 \| cholangitis \| 7 C0701818 \| choledocholithiasis \| 7 C0005683 \| bladder stone \| 5 C0007134 \| renal cell carcinoma \| 5 C0042769 \| virus infection \| 4 C0242216 \| gallbladder stones \| 4 C0008350 \| gallstone \| 4 C0030305 \| pancreatitis \| 4 C0031154 \| peritonitis \| 4 C0041471 \| typhus \| 3 C0311273 \| ascending cholangitis \| 3 C0153452 \| gallbladder cancer \| 3 C0153452 \| gallbladder ca \| 3 C0019158 \| hepatitis \| 3 C0267841 \| acalculous cholecystitis \| 3 C0036472 \| scrub typhus \| 3 C0005684 \| bladder cancer \| 3 C0155773 \| portal vein thrombosis \| 2 C0008325 \| cholecystitis \| 2 C0001418 \| adenocarcinoma \| 2 C0021843 \| bowel obstruction \| 2 C0016977 \| gallbladder disease \| 2 C0278678 \| metastatic renal cell carcinoma \| 2 C0021345 \| infectious mononucleosis \| 2 C0022661 \| end-stage renal disease \| 2 C0007137 \| squamous cell carcinoma \| 2 C0279682 \| bladder adenocarcinoma \| 1 C0023418 \| leukemia \| 1 C0001263 \| abdominal actinomycosis \| 1 C0019294 \| inguinal hernia \| 1 C1335316 \| pancreatic serous cystadenoma \| 1 C0035078 \| renal failure \| 1 C0034152 \| henoch-schonlein purpura \| 1 C0021345 \| mononucleosis \| 1 C0008340 \| choledochal cyst \| 1 C0008370 \| bile duct obstruction \| 1 C0022354 \| obstructive jaundice \| 1 C0020541 \| portal hypertension \| 1 C0008350 \| gall stone \| 1 C0008370 \| bile stasis \| 1 C0020532 \| hypersplenism \| 1 C0017168 \| gastro-esophageal reflux disease \| 1 C0002736 \| amyotrophic lateral sclerosis \| 1 C0024623 \| gastric cancer \| 1 C0023448 \| lymphocytic leukemia \| 1 C0024299 \| lymphoma \| 1 C0566602 \| primary sclerosing cholangitis \| 1 C0019101 \| hemorrhagic fever with renal syndrome \| 1 C0028754 \| obesity \| 1 C0023364 \| leptospirosis \| 1 C0015645 \| fasciitis \| 1 C0027830 \| neurofibroma \| 1 C0036421 \| systemic sclerosis \| 1 C0034362 \| q fever \| 1 C0019204 \| hepatocellular carcinoma \| 1 C0013299 \| duodenogastric reflux \| 1 C0001430 \| adenoma \| 1 C0034150 \| purpura \| 1 C0041296 \| tuberculosis \| 1 C0023434 \| small lymphocytic lymphoma \| 1 C0017168 \| esophageal reflux disease \| 1 C0024205 \| lymphadenitis \| 1 C0036472 \| tsutsugamushi \| 1 C0040053 \| thrombosis \| 1 C0019163 \| hepatitis b \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0001339 \| acute pancreatitis \| 1 C0008313 \| sclerosing cholangitis \| 1 C0019069 \| haemophilia \| 1 C0042721 \| viral hepatitis \| 1 C0010692 \| cystitis \| 1 C0023434 \| lymphocytic lymphoma \| 1 C0026946 \| fungal infection \| 1 C0004623 \| bacterial infection \| 1 C0279702 \| clear cell renal cell carcinoma \| 1 C0279651 \| gallbladder adenocarcinoma \| 1 C0020538 \| hypertension \| 1 C0014118 \| endocarditis \| 1 C0947622 \| cholecystolithiasis \| 1 C0017168 \| gastro-esophageal reflux \| 1 C0021845 \| bowel perforation \| 1 C0011860 \| type 2 diabetes mellitus \| 1 C0087086 \| thrombi \| 1 C0003950 \| ascariasis \| 1 C0036472 \| tsutsugamushi disease \| 1 C1258215 \| ileus \| 1 C0149782 \| squamous cell carcinoma of the lung \| 1 C0022116 \| ischemia \| 1 C0016977 \| gallbladder diseases \| 1 C0040053 \| thrombus \| 1 C0023890 \| cirrhosis \| 1 C0022660 \| acute renal failure \| 1 C0026946 \| fungal infections \| 1 C0017168 \| esophageal reflux \| 1 C0947622 \| gall bladder stones \| 1 C1266042 \| chromophobe renal cell carcinoma \| 1 C0010346 \| crohn's disease \| 1 C0023890 \| liver cirrhosis \| 1 C1744558 \| t cell deficiency \| 1 C0011860 \| type 2 diabetes \| 1 C0263666 \| juvenile dermatomyositis \| 1 C0019100 \| dengue hemorrhagic fever \| 1 C0022658 \| renal disease \| 1 C0013295 \| duodenal ulcer \| 1 C0235974 \| pancreatic cancer \| 1 C0034155 \| thrombotic thrombocytopenic purpura \| 1 C0011849 \| diabetes mellitus \| 1 C0011847 \| diabetes \| 1 C0206728 \| plexiform neurofibroma \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) ABCB4 \| 5244 \| CLINVAR
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:166) 1080 \| CFTR \| DISEASES 2273 \| FHL1 \| DISEASES 6793 \| STK10 \| DISEASES 57026 \| PDXP \| DISEASES 1113 \| CHGA \| DISEASES 10278 \| EFS \| DISEASES 84312 \| BRMS1L \| DISEASES 4605 \| MYBL2 \| DISEASES 8857 \| FCGBP \| DISEASES 2091 \| FBL \| DISEASES 973 \| CD79A \| DISEASES 1048 \| CEACAM5 \| DISEASES 5216 \| PFN1 \| DISEASES 3558 \| IL2 \| DISEASES 55856 \| ACOT13 \| DISEASES 9896 \| FIG4 \| DISEASES 9450 \| LY86 \| DISEASES 4057 \| LTF \| DISEASES 4292 \| MLH1 \| DISEASES 4953 \| ODC1 \| DISEASES 5740 \| PTGIS \| DISEASES 22918 \| CD93 \| DISEASES 2678 \| GGT1 \| DISEASES 968 \| CD68 \| DISEASES 3630 \| INS \| DISEASES 7251 \| TSG101 \| DISEASES 1401 \| CRP \| DISEASES 4678 \| NASP \| DISEASES 4922 \| NTS \| DISEASES 3845 \| KRAS \| DISEASES 83998 \| REG4 \| DISEASES 4440 \| MSI1 \| DISEASES 3569 \| IL6 \| DISEASES 3442 \| IFNA5 \| DISEASES 3795 \| KHK \| DISEASES 51196 \| PLCE1 \| DISEASES 9956 \| HS3ST2 \| DISEASES 10961 \| ERP29 \| DISEASES 999 \| CDH1 \| DISEASES 6855 \| SYP \| DISEASES 5067 \| CNTN3 \| DISEASES 8647 \| ABCB11 \| DISEASES 3299 \| HSF4 \| DISEASES 1421 \| CRYGD \| DISEASES 306 \| ANXA3 \| DISEASES 3827 \| KNG1 \| DISEASES 5244 \| ABCB4 \| DISEASES 26277 \| TINF2 \| DISEASES 7157 \| TP53 \| DISEASES 3145 \| HMBS \| DISEASES 7069 \| THRSP \| DISEASES 7082 \| TJP1 \| DISEASES 25836 \| NIPBL \| DISEASES 6326 \| SCN2A \| DISEASES 152273 \| FGD5 \| DISEASES 4838 \| NODAL \| DISEASES 7547 \| ZIC3 \| DISEASES 6750 \| SST \| DISEASES 3815 \| KIT \| DISEASES 90525 \| SHF \| DISEASES 5739 \| PTGIR \| DISEASES 6006 \| RHCE \| DISEASES 10630 \| PDPN \| DISEASES 2019 \| EN1 \| DISEASES 213 \| ALB \| DISEASES 4724 \| NDUFS4 \| DISEASES 6690 \| SPINK1 \| DISEASES 2661 \| GDF9 \| DISEASES 8000 \| PSCA \| DISEASES 79071 \| ELOVL6 \| DISEASES 83886 \| PRSS27 \| DISEASES 3913 \| LAMB2 \| DISEASES 10238 \| DCAF7 \| DISEASES 2147 \| F2 \| DISEASES 3265 \| HRAS \| DISEASES 6868 \| ADAM17 \| DISEASES 947 \| CD34 \| DISEASES 23209 \| MLC1 \| DISEASES 3952 \| LEP \| DISEASES 56475 \| RPRM \| DISEASES 348654 \| GEN1 \| DISEASES 11145 \| PLA2G16 \| DISEASES 9370 \| ADIPOQ \| DISEASES 6863 \| TAC1 \| DISEASES 23635 \| SSBP2 \| DISEASES 10194 \| TSHZ1 \| DISEASES 9622 \| KLK4 \| DISEASES 346389 \| MACC1 \| DISEASES 3214 \| HOXB4 \| DISEASES 3855 \| KRT7 \| DISEASES 8303 \| SNN \| DISEASES 1850 \| DUSP8 \| DISEASES 2520 \| GAST \| DISEASES 71 \| ACTG1 \| DISEASES 151888 \| BTLA \| DISEASES 2152 \| F3 \| DISEASES 885 \| CCK \| DISEASES 23583 \| SMUG1 \| DISEASES 51337 \| THEM6 \| DISEASES 22978 \| NT5C2 \| DISEASES 6251 \| RSU1 \| DISEASES 4602 \| MYB \| DISEASES 51298 \| THEG \| DISEASES 864 \| RUNX3 \| DISEASES 3638 \| INSIG1 \| DISEASES 84706 \| GPT2 \| DISEASES 83593 \| RASSF5 \| DISEASES 5265 \| SERPINA1 \| DISEASES 3240 \| HP \| DISEASES 1778 \| DYNC1H1 \| DISEASES 5169 \| ENPP3 \| DISEASES 1612 \| DAPK1 \| DISEASES 4192 \| MDK \| DISEASES 56477 \| CCL28 \| DISEASES 5742 \| PTGS1 \| DISEASES 3880 \| KRT19 \| DISEASES 9937 \| DCLRE1A \| DISEASES 9851 \| KIAA0753 \| DISEASES 28514 \| DLL1 \| DISEASES 7432 \| VIP \| DISEASES 26002 \| MOXD1 \| DISEASES 4582 \| MUC1 \| DISEASES 6280 \| S100A9 \| DISEASES 6281 \| S100A10 \| DISEASES 2045 \| EPHA7 \| DISEASES 1081 \| CGA \| DISEASES 2316 \| FLNA \| DISEASES 959 \| CD40LG \| DISEASES 7027 \| TFDP1 \| DISEASES 3055 \| HCK \| DISEASES 81689 \| ISCA1 \| DISEASES 6564 \| SLC15A1 \| DISEASES 1676 \| DFFA \| DISEASES 3980 \| LIG3 \| DISEASES 3875 \| KRT18 \| DISEASES 55576 \| STAB2 \| DISEASES 26269 \| FBXO8 \| DISEASES 307 \| ANXA4 \| DISEASES 51520 \| LARS \| DISEASES 100131390 \| SP9 \| DISEASES 174 \| AFP \| DISEASES 3098 \| HK1 \| DISEASES 728441 \| GGT2 \| DISEASES 7018 \| TF \| DISEASES 2641 \| GCG \| DISEASES 4295 \| MLN \| DISEASES 55743 \| CHFR \| DISEASES 10553 \| HTATIP2 \| DISEASES 1029 \| CDKN2A \| DISEASES 25855 \| BRMS1 \| DISEASES 7124 \| TNF \| DISEASES 5334 \| PLCL1 \| DISEASES 6892 \| TAPBP \| DISEASES 4588 \| MUC6 \| DISEASES 4583 \| MUC2 \| DISEASES 23089 \| PEG10 \| DISEASES 5447 \| POR \| DISEASES 149466 \| C1orf210 \| DISEASES 9404 \| LPXN \| DISEASES 4586 \| MUC5AC \| DISEASES 26298 \| EHF \| DISEASES 4190 \| MDH1 \| DISEASES 55733 \| HHAT \| DISEASES 5228 \| PGF \| DISEASES 102723508 \| KANTR \| DISEASES 103752588 \| PACERR \| DISEASES
Locus	(Waiting for update.)

Disease ID	707
Disease	cholecystitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:68) HP:0001081 \| Gallstones \| 33 HP:0030154 \| Gall bladder perforation \| 10 HP:0001945 \| Fever \| 8 HP:0030151 \| Cholangitis \| 7 HP:0002027 \| Abdominal pain \| 6 HP:0012531 \| Pain \| 5 HP:0005584 \| Renal cell carcinoma \| 5 HP:0010474 \| Bladder stones \| 4 HP:0030731 \| Carcinoma \| 4 HP:0100762 \| Hemobilia \| 4 HP:0001733 \| Pancreatic inflammation \| 4 HP:0100806 \| Sepsis \| 3 HP:0012115 \| Liver inflammation \| 3 HP:0009725 \| Bladder neoplasm \| 3 HP:0002860 \| Squamous cell carcinoma \| 2 HP:0001082 \| Cholecystitis \| 2 HP:0002586 \| Peritonitis \| 2 HP:0100758 \| Gangrene \| 2 HP:0002910 \| Elevated transaminases \| 2 HP:0005214 \| Bowel obstruction \| 2 HP:0003774 \| End-stage renal failure \| 2 HP:0100790 \| Hernia \| 2 HP:0002240 \| Enlarged liver \| 2 HP:0001971 \| Hypersplenism \| 1 HP:0002665 \| Lymphoma \| 1 HP:0009732 \| Plexiform neurofibroma \| 1 HP:0002605 \| Hepatic necrosis \| 1 HP:0000023 \| Inguinal hernia \| 1 HP:0001824 \| Weight loss \| 1 HP:0003613 \| Antiphospholipid antibodies \| 1 HP:0000952 \| Yellow skin \| 1 HP:0005202 \| Helicobacter pylori infection \| 1 HP:0001513 \| Obesity \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0001635 \| Congestive heart failure \| 1 HP:0045073 \| Serositis \| 1 HP:0002933 \| Ventral hernia \| 1 HP:0001735 \| Acute pancreatitis \| 1 HP:0002894 \| Neoplasia of the pancreas \| 1 HP:0002595 \| Gastrointestinal atony \| 1 HP:0001394 \| Hepatic cirrhosis \| 1 HP:0002647 \| Aortic dissection \| 1 HP:0001974 \| Leukocytosis \| 1 HP:0100615 \| Neoplasm of the ovary \| 1 HP:0100584 \| Endocarditis \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0006562 \| Viral hepatitis \| 1 HP:0100890 \| Cyst of the ductus choledochus \| 1 HP:0000969 \| Dropsy \| 1 HP:0001409 \| Portal hypertension \| 1 HP:0002588 \| Duodenal ulcer \| 1 HP:0007354 \| Amyotrophic lateral sclerosis \| 1 HP:0200119 \| Acute liver inflammation \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0100523 \| Hepatic abscess \| 1 HP:0002664 \| Neoplasia \| 1 HP:0100537 \| Inflammation of the fascia \| 1 HP:0001909 \| Leukemia \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0012251 \| ST segment elevation \| 1 HP:0030242 \| Blood clot in portal vein \| 1 HP:0001880 \| Eosinophilia \| 1 HP:0012126 \| Gastric cancer \| 1 HP:0000822 \| Hypertension \| 1 HP:0002840 \| Lymphadenitis \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0006770 \| Nonpapillary renal cell carcinoma \| 1 HP:0001402 \| Hepatocellular carcinoma \| 1

Disease ID	707
Disease	cholecystitis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:9) C0008350 \| gallstones \| 10 C0008311 \| cholangitis \| 7 C0030193 \| pain \| 5 C0242216 \| gallbladder stones \| 4 C0877570 \| hepatic artery pseudoaneurysm \| 3 C0036690 \| sepsis \| 3 C0019158 \| hepatitis \| 3 C0004610 \| bacteremia \| 2 C0016169 \| fistula \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:6)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs121918442	NA	5244	ABCB4	umls:C0008325	CLINVAR	NA	0.12	NA	ABCB4	7	87406293	G	A
rs387906528	NA	5244	ABCB4	umls:C0008325	CLINVAR	NA	0.12	NA	ABCB4	7	87443346	CT	TTG
rs397514620	NA	5244	ABCB4	umls:C0008325	CLINVAR	NA	0.12	NA	ABCB4	7	87439765	G	C,A
rs45575636	NA	5244	ABCB4	umls:C0008325	CLINVAR	NA	0.12	NA	ABCB4	7	87431528	C	T
rs58238559	NA	5244	ABCB4	umls:C0008325	CLINVAR	NA	0.12	NA	ABCB4	7	87452957	T	C
rs72552778	NA	5244	ABCB4	umls:C0008325	CLINVAR	NA	0.12	NA	ABCB4	7	87447080	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:12)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0008325	ampicillin	D000667	69-53-4	cholecystitis	MESH:D002764	marker/mechanism	1536697
C0008325	busulfan	D002066	55-98-1	cholecystitis	MESH:D002764	marker/mechanism	7612498
C0008325	cyclophosphamide	D003520	50-18-0	cholecystitis	MESH:D002764	marker/mechanism	2910431
C0008325	dapsone	D003622	80-08-0	cholecystitis	MESH:D002764	marker/mechanism	2266352
C0008325	cisplatin	D002945	15663-27-1	cholecystitis	MESH:D002764	marker/mechanism	2933968
C0008325	erythromycin	D004917	114-07-8	cholecystitis	MESH:D002764	marker/mechanism	1536697
C0008325	floxuridine	D005467	50-91-9	cholecystitis	MESH:D002764	marker/mechanism	2933968
C0008325	fluorouracil	D005472	51-21-8	cholecystitis	MESH:D002764	marker/mechanism	2935378
C0008325	gabapentin	C040029	60142-96-3	cholecystitis	MESH:D002764	marker/mechanism	12422484
C0008325	indomethacin	D007213	53-86-1	cholecystitis	MESH:D002764	therapeutic	11181007
C0008325	mitomycin	D016685	1950/7/7	cholecystitis	MESH:D002764	marker/mechanism	6225318
C0008325	morphine	D009020	57-27-2	cholecystitis	MESH:D002764	therapeutic	4089515

FDA approved drug and dosage information(Total Drugs:8)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D002764	neurontin	gabapentin	100MG	CAPSULE;ORAL	Prescription	AB	Yes	No
MESH:D002764	neurontin	gabapentin	600MG	TABLET;ORAL	Prescription	AB	Yes	No
MESH:D002764	neurontin	gabapentin	250MG/5ML	SOLUTION;ORAL	Prescription	AA	Yes	Yes
MESH:D002764	neurontin	gabapentin	0	SOLUTION; ORAL	Prescription	None	No	No
MESH:D002764	neurontin	gabapentin	600MG	TABLET; ORAL	Prescription	None	No	No
MESH:D002764	neurontin	gabapentin	800MG	CAPSULE; ORAL	Prescription	None	No	No
MESH:D002764	neurontin	gabapentin	250MG/5ML	SOLUTION; ORAL	Prescription	None	No	No
MESH:D002764	busulfex	busulfan	6MG/ML	INJECTABLE;INJECTION	Prescription	AP	Yes	Yes

FDA labeling changes(Total Drugs:8)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D002764	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D002764	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D002764	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D002764	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D002764	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D002764	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D002764	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D002764	01/13/2003	busulfex	busulfan	Part of a conditioning regimen administered prior to hematopoietic progenitor cell transplantation for a variety of malignant hematologic or non-malignant diseases	The population pharmacokinetic estimates of busulfan for clearance and volume of distribution were determined in an open-label, uncontrolled PK study in 24 pediatric patients 5 months to 16 years who received busulfan as part of a conditioning regimen administered prior to hematopoietic progenitor cell transplantation for a variety of malignant hematologic or non-malignant diseases Suggested dosing regimen	Labeling	B	-	-	-	Orphan Medical	12/3/2002	FALSE'

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