PedAM
Pediatric Disease Annotations & Medicines
| childhood leukemia | ||||
| Disease ID | 1751 |
|---|---|
| Disease | childhood leukemia |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:5) HP:0010885 | Aseptic necrosis | 2 HP:0000096 | Glomerulosclerosis | 1 HP:0001903 | Anemia | 1 HP:0001909 | Leukemia | 1 HP:0000097 | focal glomerulosclerosis | 1 |
| Disease ID | 1751 |
|---|---|
| Disease | childhood leukemia |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:1) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:11) | |||||||||||||
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| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs10508293 | 18339682 | 4524 | MTHFR | umls:C1332977 | BeFree | The maternal methylenetetrahydrofolate reductase A1298C polymorphism was found to be an effect modifier of the maternal intron 4 polymorphism of the AKR1C3 gene (rs10508293) and the childhood leukemia risk. | 0.001085767 | 2008 | AKR1C3 | 10 | 5098945 | A | G |
| rs1695 | 12827651 | 1555 | CYP2B6 | umls:C1332977 | BeFree | The role of methylenetetrahydrofolate reductase (MTHFR C677T), glutathione S-transferases (GSTM1 and GSTT1 null, GSTP1 Ile105Val), and cytochromes p450 (CYP1A1*2A) genotypes in the etiology of childhood leukemia was simultaneously investigated. | 0.000271442 | 2003 | GSTP1 | 11 | 67585218 | A | G |
| rs1695 | 12827651 | 4524 | MTHFR | umls:C1332977 | BeFree | The role of methylenetetrahydrofolate reductase (MTHFR C677T), glutathione S-transferases (GSTM1 and GSTT1 null, GSTP1 Ile105Val), and cytochromes p450 (CYP1A1*2A) genotypes in the etiology of childhood leukemia was simultaneously investigated. | 0.001085767 | 2003 | GSTP1 | 11 | 67585218 | A | G |
| rs1695 | 12827651 | 2950 | GSTP1 | umls:C1332977 | BeFree | The role of methylenetetrahydrofolate reductase (MTHFR C677T), glutathione S-transferases (GSTM1 and GSTT1 null, GSTP1 Ile105Val), and cytochromes p450 (CYP1A1*2A) genotypes in the etiology of childhood leukemia was simultaneously investigated. | 0.000271442 | 2003 | GSTP1 | 11 | 67585218 | A | G |
| rs1695 | 12827651 | 1543 | CYP1A1 | umls:C1332977 | BeFree | The role of methylenetetrahydrofolate reductase (MTHFR C677T), glutathione S-transferases (GSTM1 and GSTT1 null, GSTP1 Ile105Val), and cytochromes p450 (CYP1A1*2A) genotypes in the etiology of childhood leukemia was simultaneously investigated. | 0.001357209 | 2003 | GSTP1 | 11 | 67585218 | A | G |
| rs1695 | 12827651 | 2952 | GSTT1 | umls:C1332977 | BeFree | The role of methylenetetrahydrofolate reductase (MTHFR C677T), glutathione S-transferases (GSTM1 and GSTT1 null, GSTP1 Ile105Val), and cytochromes p450 (CYP1A1*2A) genotypes in the etiology of childhood leukemia was simultaneously investigated. | 0.000542884 | 2003 | GSTP1 | 11 | 67585218 | A | G |
| rs1695 | 12827651 | 2944 | GSTM1 | umls:C1332977 | BeFree | The role of methylenetetrahydrofolate reductase (MTHFR C677T), glutathione S-transferases (GSTM1 and GSTT1 null, GSTP1 Ile105Val), and cytochromes p450 (CYP1A1*2A) genotypes in the etiology of childhood leukemia was simultaneously investigated. | 0.000271442 | 2003 | GSTP1 | 11 | 67585218 | A | G |
| rs370216745 | 21073132 | 1728 | NQO1 | umls:C1332977 | BeFree | Our results suggest that increased risk of infant leukemia development in patients with NQO1 *1*3 polymorphism is partially dependent on the inhibition of p53 pathway, though further studies are needed to fully understand the pathological role of C465T variant in the development of childhood leukemia. | 0.000814326 | 2010 | TP53 | 17 | 7674949 | A | G |
| rs397507444 | 18339682 | 4524 | MTHFR | umls:C1332977 | BeFree | The maternal methylenetetrahydrofolate reductase A1298C polymorphism was found to be an effect modifier of the maternal intron 4 polymorphism of the AKR1C3 gene (rs10508293) and the childhood leukemia risk. | 0.001085767 | 2008 | MTHFR | 1 | 11794407 | T | G |
| rs4925 | 22293942 | 9446 | GSTO1 | umls:C1332977 | BeFree | The polymorphism A140D of GSTO1-1 has been not only associated with distinct urinary profile of arsenic metabolites in populations chronically exposed to iAs in drinking water, but also with higher risk of childhood leukemia and lung disease in non-exposed populations, suggesting that GSTO1-1 involvement in other physiologic processes different from toxics metabolism could be more relevant than is thought. | 0.000271442 | 2012 | GSTO1 | 10 | 104263031 | C | A |
| rs854560 | 22976839 | 5444 | PON1 | umls:C1332977 | BeFree | PON1 rs854560 (L55M) was associated with an increased risk of developing childhood leukemia (LM + MM, OR 1.93, 95 % CI 1.32-2.81). | 0.000271442 | 2012 | PON1 | 7 | 95316772 | A | C,G,N,T |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |