PedAM
Pediatric Disease Annotations & Medicines
| chagas disease | ||||
| Disease ID | 1006 |
|---|---|
| Disease | chagas disease |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:25) HP:0001635 | Congestive heart failure | 19 HP:0001638 | Cardiomyopathy | 6 HP:0011675 | Arrhythmias | 6 HP:0001297 | Cerebral vascular events | 4 HP:0004308 | Ventricular arrhythmia | 4 HP:0011710 | Bundle-branch block | 3 HP:0011712 | Right bundle-branch block | 3 HP:0012819 | Myocarditis | 3 HP:0001644 | Congestive cardiomyopathy | 2 HP:0002459 | Dysautonomia | 2 HP:0002019 | Dyschezia | 2 HP:0002960 | Autoimmune condition | 2 HP:0001263 | Developmental retardation | 1 HP:0001271 | Polyneuropathy | 1 HP:0000112 | Nephropathy | 1 HP:0002665 | Lymphoma | 1 HP:0005263 | Gastritis | 1 HP:0002251 | Hirschsprung megacolon | 1 HP:0001677 | Coronary artery disease | 1 HP:0002571 | Achalasia | 1 HP:0100749 | Thoracic pain | 1 HP:0012531 | Pain | 1 HP:0012266 | T-wave alternans | 1 HP:0012578 | Membranous glomerulonephritis | 1 HP:0002020 | Heartburn | 1 |
| Disease ID | 1006 |
|---|---|
| Disease | chagas disease |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:12) C0018801 | heart failure | 17 C0878544 | cardiomyopathy | 6 C0038454 | stroke | 4 C0027059 | myocarditis | 3 C0021311 | infections | 3 C0018802 | congestive heart failure | 2 C0007193 | dilated cardiomyopathy | 2 C0014848 | achalasia | 1 C0018801 | cardiac failure | 1 C0152025 | polyneuropathy | 1 C0018799 | cardiopathy | 1 C0025160 | megacolon | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:5) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs2043055 | 25743241 | 3606 | IL18 | umls:C0041234 | BeFree | We analyzed the rs2043055 marker in the IL18 gene in a cohort of Chagas disease cardiomyopathy patients (n=849) and asymptomatic subjects (n=202). | 0.000271442 | 2015 | IL18 | 11 | 112160901 | A | G |
| rs386502799 | 19456234 | 7097 | TLR2 | umls:C0041234 | BeFree | T. cruzi-infected individuals who are heterozygous for the MAL/TIRAP S180L variant that leads to a decrease in signal transduction upon ligation of TLR2 or TLR4 to their respective ligand may have a lower risk of developing CCC. | 0.000814326 | 2009 | NA | NA | NA | NA | NA |
| rs386502799 | 19456234 | 114609 | TIRAP | umls:C0041234 | BeFree | T. cruzi-infected individuals who are heterozygous for the MAL/TIRAP S180L variant that leads to a decrease in signal transduction upon ligation of TLR2 or TLR4 to their respective ligand may have a lower risk of developing CCC. | 0.000271442 | 2009 | NA | NA | NA | NA | NA |
| rs8177374 | 19456234 | 7097 | TLR2 | umls:C0041234 | BeFree | T. cruzi-infected individuals who are heterozygous for the MAL/TIRAP S180L variant that leads to a decrease in signal transduction upon ligation of TLR2 or TLR4 to their respective ligand may have a lower risk of developing CCC. | 0.000814326 | 2009 | TIRAP | 11 | 126292948 | C | T |
| rs8177374 | 19456234 | 114609 | TIRAP | umls:C0041234 | BeFree | T. cruzi-infected individuals who are heterozygous for the MAL/TIRAP S180L variant that leads to a decrease in signal transduction upon ligation of TLR2 or TLR4 to their respective ligand may have a lower risk of developing CCC. | 0.000271442 | 2009 | TIRAP | 11 | 126292948 | C | T |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |