PedAM
Pediatric Disease Annotations & Medicines
| central pontine myelinolysis | ||||
| Disease ID | 1566 |
|---|---|
| Disease | central pontine myelinolysis |
| Definition | A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6) |
| Synonym | central pontine myelinoclasis central pontine myelinolysis (disorder) central pontine myelinosis myelinoclasis, central pontine myelinolysis, central pontine myelinolysis, central pontine [disease/finding] pontine myelinolysis, central |
| DOID | |
| ICD10 | |
| UMLS | C0206083 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:12) C0206083 | central pontine myelinolysis | 16 C0020450 | hyperemesis gravidarum | 1 C0235250 | hyperemesis | 1 C0079731 | b-cell lymphoma | 1 C0376545 | hematological malignancies | 1 C0085543 | epilepsia partialis continua | 1 C0024299 | lymphoma | 1 C0019829 | hodgkin lymphoma | 1 C0024305 | non-hodgkin lymphoma | 1 C0019202 | wilson disease | 1 C0079744 | diffuse large b-cell lymphoma | 1 C0014544 | epilepsia | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:21) 6543 | SLC8A2 | DISEASES 55640 | FLVCR2 | DISEASES 3630 | INS | DISEASES 50617 | ATP6V0A4 | DISEASES 23523 | CABIN1 | DISEASES 760 | CA2 | DISEASES 6529 | SLC6A1 | DISEASES 55957 | LIN37 | DISEASES 171558 | PTCRA | DISEASES 375611 | SLC26A5 | DISEASES 358 | AQP1 | DISEASES 2305 | FOXM1 | DISEASES 5498 | PPOX | DISEASES 2526 | FUT4 | DISEASES 112476 | PRRT2 | DISEASES 8718 | TNFRSF25 | DISEASES 551 | AVP | DISEASES 4155 | MBP | DISEASES 361 | AQP4 | DISEASES 4099 | MAG | DISEASES 5744 | PTHLH | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 1566 |
|---|---|
| Disease | central pontine myelinolysis |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:10) HP:0001337 | Tremor | 2 HP:0011096 | Demyelination | 2 HP:0012539 | Non-Hodgkin lymphoma | 1 HP:0002665 | Lymphoma | 1 HP:0012191 | B-cell lymphoma | 1 HP:0012188 | Hyperemesis gravidarum | 1 HP:0012189 | Hodgkin disease | 1 HP:0012847 | Epilepsia partialis continua | 1 HP:0002902 | Hyponatremia | 1 HP:0003228 | High blood sodium levels | 1 |
| Disease ID | 1566 |
|---|---|
| Disease | central pontine myelinolysis |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:3) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0206083 | cyclophosphamide | D003520 | 50-18-0 | myelinolysis, central pontine | MESH:D017590 | marker/mechanism | 18988633 | ||
| C0206083 | methotrexate | D008727 | 1959/5/2 | myelinolysis, central pontine | MESH:D017590 | marker/mechanism | 17357801 | ||
| C0206083 | tacrolimus | D016559 | 109581-93-3 | myelinolysis, central pontine | MESH:D017590 | marker/mechanism | 12819864 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |