PedAM

Pediatric Disease Annotations & Medicines


	carcinoid tumor

Disease ID	1525
Disease	carcinoid tumor
Definition	A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
Synonym	[m]carcinoid tumor nos [m]carcinoid tumor nos (morphologic abnormality) [m]carcinoid tumors [m]carcinoid tumors nos [m]carcinoid tumors nos (morphologic abnormality) [m]carcinoid tumour nos [m]carcinoid tumours [m]carcinoid tumours nos carcinoid carcinoid tumor (disorder) carcinoid tumor - morphology carcinoid tumor - morphology (morphologic abnormality) carcinoid tumor [disease/finding] carcinoid tumor nos carcinoid tumors carcinoid tumour carcinoid tumour - morphology carcinoid tumours carcinoids tumor, carcinoid tumors, carcinoid
UMLS	C0007095
MeSH	D002276
SNOMED-CT	SNOMEDCT_US_2016_09_01:443492008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:55) C0039538 \| teratoma \| 7 C0024586 \| carcinoid syndrome \| 5 C1140680 \| ovarian ca \| 3 C0017152 \| gastritis \| 3 C0010481 \| cushing's syndrome \| 3 C0494165 \| liver metastases \| 3 C0027662 \| multiple endocrine neoplasia \| 3 C1368903 \| cystic teratoma \| 3 C0011649 \| mature cystic teratoma \| 2 C0009806 \| constipation \| 2 C0017154 \| atrophic gastritis \| 2 C0001430 \| adenoma \| 2 C1368910 \| mature teratoma \| 2 C0494165 \| hepatic metastases \| 2 C0206754 \| neuroendocrine tumor \| 2 C0280131 \| ovarian teratoma \| 2 C0004030 \| aspergillosis \| 2 C0011644 \| scleroderma \| 1 C0494165 \| liver metastasis \| 1 C0002871 \| anemia \| 1 C0032285 \| pneumonia \| 1 C0022116 \| ischaemia \| 1 C0032326 \| pneumothorax \| 1 C0006142 \| breast cancer \| 1 C0004096 \| asthma \| 1 C0020502 \| hyperparathyroidism \| 1 C0002892 \| pernicious anemia \| 1 C0541912 \| duodenal ca \| 1 C0011570 \| depression \| 1 C0018021 \| struma \| 1 C0011991 \| diarrhea \| 1 C0018916 \| hemangiomas \| 1 C0027873 \| neuromyelitis optica \| 1 C1704273 \| endometrial polyp \| 1 C0302592 \| cervical ca \| 1 C0686619 \| lymph node metastases \| 1 C0007130 \| mucinous adenocarcinoma \| 1 C0025267 \| multiple endocrine neoplasia syndrome type 1 \| 1 C0206667 \| adrenocortical adenoma \| 1 C0010481 \| cushing syndrome \| 1 C0032000 \| pituitary adenoma \| 1 C0279702 \| clear cell renal cell carcinoma \| 1 C0028242 \| nocardiosis \| 1 C1335155 \| ovarian cystic teratoma \| 1 C0003467 \| anxiety \| 1 C0027662 \| multiple endocrine neoplasia syndrome \| 1 C0001418 \| adenocarcinoma \| 1 C0036202 \| sarcoidosis \| 1 C0007137 \| squamous cell carcinoma \| 1 C0029927 \| ovarian cyst \| 1 C0042109 \| urticaria \| 1 C0017154 \| chronic atrophic gastritis \| 1 C0206754 \| neuroendocrine tumors \| 1 C0014117 \| endocardial fibroelastosis \| 1 C0221002 \| primary hyperparathyroidism \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 2257 \| FGF12 \| infer 55614 \| KIF16B \| infer 6558 \| SLC12A2 \| infer
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1525
Disease	carcinoid tumor
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:41) HP:0030445 \| Lung carcinoid tumor \| 9 HP:0002664 \| Neoplasia \| 9 HP:0009792 \| Teratoma \| 7 HP:0100568 \| Endocrine neoplasia \| 3 HP:0005263 \| Gastritis \| 3 HP:0100570 \| Carcinoid tumor \| 2 HP:0012226 \| Ovarian teratoma \| 2 HP:0002019 \| Dyschezia \| 2 HP:0012531 \| Pain \| 1 HP:0002893 \| Pituitary adenoma \| 1 HP:0002107 \| Collapsed lung \| 1 HP:0012720 \| Nasal neoplasm \| 1 HP:0002013 \| Emesis \| 1 HP:0002090 \| Pneumonia \| 1 HP:0001578 \| Hypercortisolism \| 1 HP:0000085 \| Horseshoe kidney \| 1 HP:0030731 \| Carcinoma \| 1 HP:0000739 \| Anxiety \| 1 HP:0008200 \| Primary hyperparathyroidism \| 1 HP:0002176 \| Spinal cord compression \| 1 HP:0001903 \| Anemia \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0001063 \| Acrocyanosis \| 1 HP:0010960 \| Bronchopulmonary sequestration \| 1 HP:0100632 \| Pulmonary sequestration \| 1 HP:0008256 \| Adrenocortical adenomas \| 1 HP:0000138 \| Ovarian cyst \| 1 HP:0100790 \| Hernia \| 1 HP:0002582 \| Chronic atrophic gastritis \| 1 HP:0006770 \| Nonpapillary renal cell carcinoma \| 1 HP:0002716 \| Lymph node hyperplasia \| 1 HP:0100324 \| Progressive systemic scleroderma \| 1 HP:0010783 \| Erythema \| 1 HP:0000843 \| Hyperparathyroidism \| 1 HP:0001025 \| Hives \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0002099 \| Asthma \| 1 HP:0001706 \| Endocardial fibroelastosis \| 1 HP:0002014 \| Diarrhea \| 1 HP:0030834 \| Shoulder pain \| 1 HP:0000716 \| Depression \| 1

Disease ID	1525
Disease	carcinoid tumor
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:4) C0494165 \| liver metastases \| 3 C0494165 \| hepatic metastases \| 2 C0153690 \| bone metastases \| 1 C0279702 \| clear cell renal cell carcinoma \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10089	21139019	6558	SLC12A2	umls:C0007095	GAD	[A pilot genome-wide association study shows genomic variants enriched in the non-tumor cells of patients with well-differentiated neuroendocrine tumors of the ileum.]	0.002367032	2011	SLC12A2	5	128186851	C	T
rs2208059	21139019	55614	KIF16B	umls:C0007095	GAD	[A pilot genome-wide association study shows genomic variants enriched in the non-tumor cells of patients with well-differentiated neuroendocrine tumors of the ileum.]	0.002367032	2011	KIF16B	20	16330665	T	C
rs975121	21139019	2257	FGF12	umls:C0007095	GAD	[A pilot genome-wide association study shows genomic variants enriched in the non-tumor cells of patients with well-differentiated neuroendocrine tumors of the ileum.]	0.002367032	2011	FGF12	3	192179429	G	A,C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:3)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0007095	fluorouracil	D005472	51-21-8	carcinoid tumor	MESH:D002276	therapeutic	16051944
C0007095	octreotide	D015282	83150-76-9	carcinoid tumor	MESH:D002276	therapeutic	11416760
C0007095	streptozocin	D013311	18883-66-4	carcinoid tumor	MESH:D002276	therapeutic	16051944

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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