PedAM

Pediatric Disease Annotations & Medicines


	carcinoid syndrome

Disease ID	312
Disease	carcinoid syndrome
Definition	A symptom complex associated with CARCINOID TUMOR and characterized by attacks of severe flushing of the skin, diarrheal watery stools, bronchoconstriction, sudden drops in blood pressure, edema, and ascites. The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. Symptoms are caused by tumor secretion of serotonin, prostaglandins, and other biologically active substances. Cardiac manifestations constitute CARCINOID HEART DISEASE. (Dorland, 27th ed; Stedman, 25th ed)
Synonym	carcinoid syndrome (disorder) carcinoid syndrome, malignant carcinoid syndromes, malignant carcinoids syndrome excessive serotonin secretion hormonal tumor hormonal tumor (disorder) hormonal tumour hormone secretion by carcinoid tumor hormone secretion by carcinoid tumors hormone secretion by carcinoid tumour malignant carcinoid syndrome malignant carcinoid syndrome [disease/finding] malignant carcinoid syndromes serotonin syndrome syndrome serotonin syndrome, malignant carcinoid syndromes, malignant carcinoid
Orphanet	ORPHANET:43116
DOID	DOID:8600
ICD10	ICD10CM:E34.0
UMLS	C0024586
MeSH	D008303 D020230
SNOMED-CT	SNOMEDCT_US_2016_09_01:35868009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:24) C0011991 \| diarrhea \| 11 C0206754 \| neuroendocrine tumor \| 10 C0018799 \| heart disease \| 8 C0206754 \| neuroendocrine tumors \| 7 C0011991 \| diarrhoea \| 3 C0206754 \| neuroendocrine tumour \| 2 C0494165 \| liver metastases \| 2 C0018824 \| valvular heart disease \| 2 C0020538 \| hypertension \| 2 C0494165 \| hepatic metastases \| 1 C0020598 \| hypoglycaemia \| 1 C0031117 \| peripheral neuropathy \| 1 C0033975 \| psychosis \| 1 C0024586 \| malignant carcinoid syndrome \| 1 C0027849 \| neuroleptic malignant syndrome \| 1 C0242379 \| lung cancer \| 1 C0011570 \| depression \| 1 C0014117 \| endocardial fibroelastosis \| 1 C1384514 \| primary aldosteronism \| 1 C0267557 \| secretory diarrhea \| 1 C0020428 \| aldosteronism \| 1 C0149925 \| small cell lung cancer \| 1 C0004352 \| autism \| 1 C0541912 \| duodenal ca \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	312
Disease	carcinoid syndrome
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:28) HP:0002014 \| Diarrhea \| 11 HP:0100570 \| Carcinoid tumor \| 11 HP:0002664 \| Neoplasia \| 9 HP:0010783 \| Erythema \| 7 HP:0001945 \| Fever \| 3 HP:0012531 \| Pain \| 2 HP:0000822 \| Hypertension \| 2 HP:0100543 \| Cognitive deficits \| 1 HP:0000969 \| Dropsy \| 1 HP:0000622 \| Blurred vision \| 1 HP:0000709 \| Psychosis \| 1 HP:0002013 \| Emesis \| 1 HP:0001649 \| Tachycardia \| 1 HP:0001347 \| Hyperreflexia \| 1 HP:0030357 \| Small cell lung carcinoma \| 1 HP:0002045 \| Abnormally low body temperature \| 1 HP:0000717 \| Autism \| 1 HP:0009830 \| Peripheral neuritis \| 1 HP:0007430 \| Generalized edema \| 1 HP:0012532 \| Chronic pain \| 1 HP:0000716 \| Depression \| 1 HP:0001289 \| Confusion \| 1 HP:0002169 \| Clonus \| 1 HP:0005208 \| Secretory diarrhea \| 1 HP:0002063 \| Muscle rigidity \| 1 HP:0001943 \| Hypoglycemia \| 1 HP:0001706 \| Endocardial fibroelastosis \| 1 HP:0001962 \| Palpitations \| 1

Disease ID	312
Disease	carcinoid syndrome
Manually Symptom	UMLS \| Name(Total Manually Symptoms:31) C2364050 \| hypothermia C2039684 \| systemic symptoms C2003861 \| flushing C1963179 \| nausea C1963123 \| valvular heart disease C1963091 \| diarrhea C1368041 \| pancreatic somatostatinoma C1336705 \| testicular carcinoid tumor C1027109 \| scleroderma C0520679 \| obstructive sleep apnoea C0494165 \| liver metastases C0426576 \| gastrointestinal symptoms C0267557 \| secretory diarrhoea C0264545 \| pleural fibrosis C0239182 \| watery diarrhea C0235527 \| right-sided heart failure C0234131 \| motor dysfunction C0233401 \| psychiatric symptoms C0221347 \| acrocyanosis C0037285 \| skin manifestations C0037284 \| skin lesions C0034088 \| pulmonary regurgitation C0034069 \| lung fibrosis C0033975 \| psychosis C0022660 \| acute renal failure C0018801 \| heart failure C0017086 \| gangrene C0016978 \| tumor of the gallbladder C0011991 \| diarrhoea C0007121 \| carcinoma of bronchus C0007095 \| carcinoid tumor
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:8) C0011991 \| diarrhea \| 10 C0016382 \| flushing \| 7 C0007095 \| carcinoid tumor \| 4 C0011991 \| diarrhoea \| 3 C0018824 \| valvular heart disease \| 2 C0494165 \| liver metastases \| 2 C2039684 \| systemic symptoms \| 1 C0020672 \| hypothermia \| 1

Manually Genotype(Total Text Mining Genotypes:0)
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All Snps(Total Genotypes:0)
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GWASdb Annotation(Total Genotypes:0)
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GWASdb Snp Trait(Total Genotypes:0)
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Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0001919	Acute kidney injury	MP:0002135	abnormal kidney morphology;HP:0001635	Congestive heart failure

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0001063	Acrocyanosis	MP:0009625	abnormal abdominal lymph node morphology;HP:0001919	Acute kidney injury

Chemical(Total Drugs:22)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0024586	amitriptyline	D000639	50-48-6	serotonin syndrome	MESH:D020230	marker/mechanism	8869767
C0024586	buspirone	D002065	36505-84-7	serotonin syndrome	MESH:D020230	marker/mechanism	8681579
C0024586	chlorpromazine	D002746	50-53-3	serotonin syndrome	MESH:D020230	therapeutic	8862337
C0024586	ciprofloxacin	D002939	85721-33-1	serotonin syndrome	MESH:D020230	marker/mechanism	19996237
C0024586	citalopram	D015283	59729-33-8	serotonin syndrome	MESH:D020230	marker/mechanism	11889332
C0024586	cyclosporine	D016572	59865-13-3	serotonin syndrome	MESH:D020230	marker/mechanism	18243426
C0024586	cyproheptadine	D003533	129-03-3	serotonin syndrome	MESH:D020230	therapeutic	17403991
C0024586	dihydroergotamine	D004087	511-12-6	serotonin syndrome	MESH:D020230	marker/mechanism	8869767
C0024586	fluconazole	D015725	86386-73-4	serotonin syndrome	MESH:D020230	marker/mechanism	18585543
C0024586	fluoxetine	D005473	54910-89-3	serotonin syndrome	MESH:D020230	marker/mechanism	11384912
C0024586	fluvoxamine	D016666	54739-18-3	serotonin syndrome	MESH:D020230	marker/mechanism	12456895
C0024586	imipramine	D007099	50-49-7	serotonin syndrome	MESH:D020230	marker/mechanism	8869767
C0024586	linezolid	D000069349	-	serotonin syndrome	MESH:D020230	marker/mechanism	18624020
C0024586	methadone	D008691	76-99-3	serotonin syndrome	MESH:D020230	marker/mechanism	17187532
C0024586	dextromethorphan	D003915	125-71-3	serotonin syndrome	MESH:D020230	marker/mechanism	12456895
C0024586	methylphenidate	D008774	113-45-1	serotonin syndrome	MESH:D020230	marker/mechanism	20298736
C0024586	methysergide	D008784	361-37-5	serotonin syndrome	MESH:D020230	marker/mechanism	8869767
C0024586	methysergide	D008784	361-37-5	serotonin syndrome	MESH:D020230	therapeutic	3711372
C0024586	propranolol	D011433	525-66-6	serotonin syndrome	MESH:D020230	therapeutic	15707818
C0024586	tramadol	D014147	27203-92-5	serotonin syndrome	MESH:D020230	marker/mechanism	11384912
C0024586	cetirizine	D017332	83881-51-0	malignant carcinoid syndrome	MESH:D008303	therapeutic	18463367
C0024586	octreotide	D015282	83150-76-9	malignant carcinoid syndrome	MESH:D008303	therapeutic	18463367

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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