PedAM

Pediatric Disease Annotations & Medicines


	cannabis abuse

Disease ID	1738
Disease	cannabis abuse
Synonym	abuse cannabis abuse, cannabis cannabis abuse (disorder)
DOID	DOID:9505
UMLS	C0006868
SNOMED-CT	SNOMEDCT_US_2016_09_01:37344009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:3) C0036341 \| schizophrenia \| 7 C0033975 \| psychosis \| 5 C0033975 \| psychoses \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:43) 1815 \| DRD4 \| DISEASES 5816 \| PVALB \| DISEASES 10598 \| AHSA1 \| DISEASES 10404 \| CPQ \| DISEASES 1432 \| MAPK14 \| DISEASES 7841 \| MOGS \| DISEASES 6532 \| SLC6A4 \| DISEASES 10728 \| PTGES3 \| DISEASES 2033 \| EP300 \| DISEASES 55749 \| CCAR1 \| DISEASES 3700 \| ITIH4 \| DISEASES 3484 \| IGFBP1 \| DISEASES 10280 \| SIGMAR1 \| DISEASES 909 \| CD1A \| DISEASES 1142 \| CHRNB3 \| DISEASES 152185 \| SPICE1 \| DISEASES 1138 \| CHRNA5 \| DISEASES 8625 \| RFXANK \| DISEASES 255239 \| ANKK1 \| DISEASES 1136 \| CHRNA3 \| DISEASES 246213 \| SLC17A8 \| DISEASES 57142 \| RTN4 \| DISEASES 11315 \| PARK7 \| DISEASES 3084 \| NRG1 \| DISEASES 2571 \| GAD1 \| DISEASES 23607 \| CD2AP \| DISEASES 8936 \| WASF1 \| DISEASES 57016 \| AKR1B10 \| DISEASES 1312 \| COMT \| DISEASES 1813 \| DRD2 \| DISEASES 27185 \| DISC1 \| DISEASES 1268 \| CNR1 \| DISEASES 4803 \| NGF \| DISEASES 115004 \| MB21D1 \| DISEASES 6342 \| SCP2 \| DISEASES 29994 \| BAZ2B \| DISEASES 654364 \| NME1-NME2 \| DISEASES 4831 \| NME2 \| DISEASES 5091 \| PC \| DISEASES 23109 \| DDN \| DISEASES 10163 \| WASF2 \| DISEASES 627 \| BDNF \| DISEASES 7178 \| TPT1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1738
Disease	cannabis abuse
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:7) HP:0100753 \| Schizophrenia \| 7 HP:0000709 \| Psychosis \| 5 HP:0002013 \| Emesis \| 4 HP:0002017 \| Nausea and vomiting \| 1 HP:0000708 \| Behavioral problems \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0002018 \| Nausea \| 1

Disease ID	1738
Disease	cannabis abuse
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:3) C0033975 \| psychosis \| 5 C0033975 \| psychoses \| 1 C0871189 \| psychotic symptoms \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:9)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1051730	25770649	1136	CHRNA3	umls:C0006868	BeFree	Rs16969968 in CHRNA5 (and its proxy, rs1051730 in CHRNA3) and rs1451240, a proxy for rs13280604 in CHRNB3, were associated with CPD after Bonferroni correction (p<0.006). rs1451240 was also associated with DSM-IV cannabis abuse/dependence.	0.000271442	2015	CHRNA3	15	78601997	G	A
rs1051730	25770649	1142	CHRNB3	umls:C0006868	BeFree	Rs16969968 in CHRNA5 (and its proxy, rs1051730 in CHRNA3) and rs1451240, a proxy for rs13280604 in CHRNB3, were associated with CPD after Bonferroni correction (p<0.006). rs1451240 was also associated with DSM-IV cannabis abuse/dependence.	0.000271442	2015	CHRNA3	15	78601997	G	A
rs1051730	25770649	1138	CHRNA5	umls:C0006868	BeFree	Rs16969968 in CHRNA5 (and its proxy, rs1051730 in CHRNA3) and rs1451240, a proxy for rs13280604 in CHRNB3, were associated with CPD after Bonferroni correction (p<0.006). rs1451240 was also associated with DSM-IV cannabis abuse/dependence.	0.000271442	2015	CHRNA3	15	78601997	G	A
rs13280604	25770649	1136	CHRNA3	umls:C0006868	BeFree	Rs16969968 in CHRNA5 (and its proxy, rs1051730 in CHRNA3) and rs1451240, a proxy for rs13280604 in CHRNB3, were associated with CPD after Bonferroni correction (p<0.006). rs1451240 was also associated with DSM-IV cannabis abuse/dependence.	0.000271442	2015	CHRNB3;LOC105379396	8	42704443	G	A
rs13280604	25770649	1142	CHRNB3	umls:C0006868	BeFree	Rs16969968 in CHRNA5 (and its proxy, rs1051730 in CHRNA3) and rs1451240, a proxy for rs13280604 in CHRNB3, were associated with CPD after Bonferroni correction (p<0.006). rs1451240 was also associated with DSM-IV cannabis abuse/dependence.	0.000271442	2015	CHRNB3;LOC105379396	8	42704443	G	A
rs13280604	25770649	1138	CHRNA5	umls:C0006868	BeFree	Rs16969968 in CHRNA5 (and its proxy, rs1051730 in CHRNA3) and rs1451240, a proxy for rs13280604 in CHRNB3, were associated with CPD after Bonferroni correction (p<0.006). rs1451240 was also associated with DSM-IV cannabis abuse/dependence.	0.000271442	2015	CHRNB3;LOC105379396	8	42704443	G	A
rs1451240	25770649	1136	CHRNA3	umls:C0006868	BeFree	Rs16969968 in CHRNA5 (and its proxy, rs1051730 in CHRNA3) and rs1451240, a proxy for rs13280604 in CHRNB3, were associated with CPD after Bonferroni correction (p<0.006). rs1451240 was also associated with DSM-IV cannabis abuse/dependence.	0.000271442	2015	NA	8	42691568	A	G
rs1451240	25770649	1142	CHRNB3	umls:C0006868	BeFree	Rs16969968 in CHRNA5 (and its proxy, rs1051730 in CHRNA3) and rs1451240, a proxy for rs13280604 in CHRNB3, were associated with CPD after Bonferroni correction (p<0.006). rs1451240 was also associated with DSM-IV cannabis abuse/dependence.	0.000271442	2015	NA	8	42691568	A	G
rs1451240	25770649	1138	CHRNA5	umls:C0006868	BeFree	Rs16969968 in CHRNA5 (and its proxy, rs1051730 in CHRNA3) and rs1451240, a proxy for rs13280604 in CHRNB3, were associated with CPD after Bonferroni correction (p<0.006). rs1451240 was also associated with DSM-IV cannabis abuse/dependence.	0.000271442	2015	NA	8	42691568	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:10)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	192995213	rs9427573	C	T	rs9427573	21668797	5.00E-06	NA	2.56	[1.71-3.82]	708 cases; 2,346 controls	NOPOP(3054)	ALL(3054)	NOPOP(3054)	ALL(3054)	Cannabis dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9505	cannabis abuse	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	C	UCHL5
2	59072969	rs17552189	C	T	rs17552189	21668797	4.00E-06	NA	1.4	[1.21-1.61]	708 cases; 2,346 controls	NOPOP(3054)	ALL(3054)	NOPOP(3054)	ALL(3054)	Cannabis dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9505	cannabis abuse	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	C	FLJ30838
3	106288950	rs12491921	T	C	rs12491921	21668797	1.00E-06	NA	1.39	[1.22-1.58]	708 cases; 2,346 controls	NOPOP(3054)	ALL(3054)	NOPOP(3054)	ALL(3054)	Cannabis dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9505	cannabis abuse	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	T	NA
10	29289031	rs11007350	C	T	rs11007350	21668797	3.00E-06	NA	1.37	[1.20-1.56]	708 cases; 2,346 controls	NOPOP(3054)	ALL(3054)	NOPOP(3054)	ALL(3054)	Cannabis dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9505	cannabis abuse	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	C	NA
12	105017164	rs12811699	C	T	rs12811699	21668797	8.00E-06	NA	1.74	[1.36-2.21]	708 cases; 2,346 controls	NOPOP(3054)	ALL(3054)	NOPOP(3054)	ALL(3054)	Cannabis dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9505	cannabis abuse	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	C	CHST11
13	23744379	rs9507041	C	T	rs9507041	21668797	8.00E-06	NA	1.55	[1.28-1.88]	708 cases; 2,346 controls	NOPOP(3054)	ALL(3054)	NOPOP(3054)	ALL(3054)	Cannabis dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9505	cannabis abuse	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	C	NA
17	54192523	rs1431318	A	G	rs1431318	21668797	9.00E-07	NA	1.41	[1.23-1.62]	708 cases; 2,346 controls	NOPOP(3054)	ALL(3054)	NOPOP(3054)	ALL(3054)	Cannabis dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9505	cannabis abuse	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	C	NA
17	54203360	rs8065311	G	T	rs8065311	21668797	2.00E-06	NA	1.43	[1.23-1.66]	708 cases; 2,346 controls	NOPOP(3054)	ALL(3054)	NOPOP(3054)	ALL(3054)	Cannabis dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9505	cannabis abuse	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	T	NA
17	54278715	rs1019238	G	A	rs1019238	21668797	6.00E-07	NA	1.45	[1.25-1.68]	708 cases; 2,346 controls	NOPOP(3054)	ALL(3054)	NOPOP(3054)	ALL(3054)	Cannabis dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9505	cannabis abuse	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	A	ANKFN1
22	50350971	rs28372448	G	A	rs28372448	21668797	8.00E-06	NA	1.68	[1.34-2.11]	708 cases; 2,346 controls	NOPOP(3054)	ALL(3054)	NOPOP(3054)	ALL(3054)	Cannabis dependence	HPOID:0000707	Abnormality of the nervous system	DOID:9505	cannabis abuse	NA	NA	NA	NA	Drug abuse	NA	Research Support, N.I.H., Extramural	A	NA

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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