PedAM

Pediatric Disease Annotations & Medicines


	bulimia nervosa

Disease ID	537
Disease	bulimia nervosa
Definition	eating disorder that involves eating massive quantities of food (binge eating) and then eliminating the food by inappropriate compensatory methods to prevent weight gain, such as self induced vomiting or strong laxatives.
Synonym	[x]bulimia nervosa [x]hyperorexia nervosa bn - bulimia nervosa bulimia nervosa (disorder) bulimia nervosa [disease/finding] nervosa, bulimia
DOID	DOID:12129
ICD10	ICD10CM:F50.2
UMLS	C2267227
MeSH	D052018
SNOMED-CT	SNOMEDCT_US_2016_09_01:78004001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:15) C0013473 \| eating disorder \| 5 C0003125 \| anorexia nervosa \| 4 C0022104 \| irritable bowel syndrome \| 1 C0006012 \| borderline personality disorder \| 1 C0005586 \| bipolar disorder \| 1 C0023051 \| laryngeal disorders \| 1 C0003467 \| anxiety \| 1 C0235250 \| hyperemesis \| 1 C0040053 \| thrombosis \| 1 C0022660 \| acute renal failure \| 1 C0022104 \| irritable bowel \| 1 C0011570 \| depression \| 1 C0037198 \| sinus thrombosis \| 1 C0003469 \| anxiety disorder \| 1 C0009492 \| compartment syndrome \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) NKAIN3 \| 286183 \| GWASCAT BDNF \| 627 \| CTD_human CHODL \| 140578 \| GWASCAT
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:117) 2101 \| ESRRA \| DISEASES 1815 \| DRD4 \| DISEASES 27248 \| ERLEC1 \| DISEASES 9552 \| SPAG7 \| DISEASES 2999 \| GZMH \| DISEASES 5020 \| OXT \| DISEASES 5539 \| PPY \| DISEASES 5961 \| PRPH2 \| DISEASES 5754 \| PTK7 \| DISEASES 83444 \| INO80B \| DISEASES 2691 \| GHRH \| DISEASES 2693 \| GHSR \| DISEASES 4852 \| NPY \| DISEASES 1271 \| CNTFR \| DISEASES 28981 \| IFT81 \| DISEASES 2166 \| FAAH \| DISEASES 92797 \| HELB \| DISEASES 7166 \| TPH1 \| DISEASES 3630 \| INS \| DISEASES 27112 \| FAM155B \| DISEASES 51540 \| SCLY \| DISEASES 1208 \| CLPS \| DISEASES 9177 \| HTR3B \| DISEASES 6532 \| SLC6A4 \| DISEASES 7301 \| TYRO3 \| DISEASES 56925 \| LXN \| DISEASES 5443 \| POMC \| DISEASES 80321 \| CEP70 \| DISEASES 4986 \| OPRK1 \| DISEASES 55749 \| CCAR1 \| DISEASES 6531 \| SLC6A3 \| DISEASES 79017 \| GGCT \| DISEASES 3358 \| HTR2C \| DISEASES 1392 \| CRH \| DISEASES 4915 \| NTRK2 \| DISEASES 53942 \| CNTN5 \| DISEASES 3192 \| HNRNPU \| DISEASES 181 \| AGRP \| DISEASES 3060 \| HCRT \| DISEASES 81570 \| CLPB \| DISEASES 64320 \| RNF25 \| DISEASES 136242 \| PRSS37 \| DISEASES 552 \| AVPR1A \| DISEASES 4160 \| MC4R \| DISEASES 4054 \| LTBP3 \| DISEASES 5617 \| PRL \| DISEASES 3479 \| IGF1 \| DISEASES 9575 \| CLOCK \| DISEASES 3952 \| LEP \| DISEASES 619373 \| MBOAT4 \| DISEASES 3350 \| HTR1A \| DISEASES 9370 \| ADIPOQ \| DISEASES 6181 \| RPLP2 \| DISEASES 10194 \| TSHZ1 \| DISEASES 5021 \| OXTR \| DISEASES 10025 \| MED16 \| DISEASES 284359 \| IZUMO1 \| DISEASES 277 \| AMY1B \| DISEASES 256933 \| NPB \| DISEASES 10810 \| WASF3 \| DISEASES 51738 \| GHRL \| DISEASES 885 \| CCK \| DISEASES 57142 \| RTN4 \| DISEASES 3363 \| HTR7 \| DISEASES 10570 \| DPYSL4 \| DISEASES 4128 \| MAOA \| DISEASES 10612 \| TRIM3 \| DISEASES 1508 \| CTSB \| DISEASES 10516 \| FBLN5 \| DISEASES 3359 \| HTR3A \| DISEASES 8794 \| TNFRSF10C \| DISEASES 257194 \| NEGR1 \| DISEASES 93034 \| NT5C1B \| DISEASES 5792 \| PTPRF \| DISEASES 5697 \| PYY \| DISEASES 1312 \| COMT \| DISEASES 1813 \| DRD2 \| DISEASES 128153 \| SPATA17 \| DISEASES 343035 \| RD3 \| DISEASES 3664 \| IRF6 \| DISEASES 2494 \| NR5A2 \| DISEASES 7390 \| UROS \| DISEASES 5550 \| PREP \| DISEASES 1268 \| CNR1 \| DISEASES 2316 \| FLNA \| DISEASES 3351 \| HTR1B \| DISEASES 278 \| AMY1C \| DISEASES 276 \| AMY1A \| DISEASES 10555 \| AGPAT2 \| DISEASES 79717 \| PPCS \| DISEASES 4879 \| NPPB \| DISEASES 4878 \| NPPA \| DISEASES 114798 \| SLITRK1 \| DISEASES 3356 \| HTR2A \| DISEASES 285440 \| CYP4V2 \| DISEASES 56261 \| GPCPD1 \| DISEASES 2625 \| GATA3 \| DISEASES 387755 \| INSC \| DISEASES 551 \| AVP \| DISEASES 8544 \| PIR \| DISEASES 51761 \| ATP8A2 \| DISEASES 9467 \| SH3BP5 \| DISEASES 5901 \| RAN \| DISEASES 80196 \| RNF34 \| DISEASES 145270 \| PRIMA1 \| DISEASES 6152 \| RPL24 \| DISEASES 5530 \| PPP3CA \| DISEASES 594857 \| NPS \| DISEASES 3267 \| AGFG1 \| DISEASES 2641 \| GCG \| DISEASES 23210 \| JMJD6 \| DISEASES 94122 \| SYTL5 \| DISEASES 64065 \| PERP \| DISEASES 627 \| BDNF \| DISEASES 23089 \| PEG10 \| DISEASES 79068 \| FTO \| DISEASES 23601 \| CLEC5A \| DISEASES
Locus	(Waiting for update.)

Disease ID	537
Disease	bulimia nervosa
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:14) HP:0002013 \| Emesis \| 4 HP:0002039 \| Anorexia \| 4 HP:0001824 \| Weight loss \| 2 HP:0012075 \| Personality disorder \| 2 HP:0012076 \| Borderline personality disorder \| 1 HP:0000718 \| Aggressive behaviour \| 1 HP:0100710 \| Impulsivity \| 1 HP:0000751 \| Personality changes \| 1 HP:0000742 \| Self-mutilation \| 1 HP:0000716 \| Depression \| 1 HP:0000739 \| Anxiety \| 1 HP:0007018 \| Attention deficits \| 1 HP:0007302 \| Bipolar disorder \| 1 HP:0002591 \| Voracious appetite \| 1

Disease ID	537
Disease	bulimia nervosa
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:5) C0013473 \| eating disorder \| 5 C0003123 \| anorexia \| 4 C0042963 \| vomiting \| 4 C0003467 \| anxiety \| 1 C0011570 \| depression \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:11)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1042571	24831852	181	AGRP	umls:C2267227	BeFree	AGRP rs13338499 polymorphism was associated with lowest illness-related BMI in those with AN (p = 0.0013), and NTRK2 rs1042571 was associated with highest BMI in those with BN (p = 0.0018).	0.000271442	2014	POMC	2	25161018	G	A
rs1042571	24831852	4915	NTRK2	umls:C2267227	BeFree	AGRP rs13338499 polymorphism was associated with lowest illness-related BMI in those with AN (p = 0.0013), and NTRK2 rs1042571 was associated with highest BMI in those with BN (p = 0.0018).	0.000271442	2014	POMC	2	25161018	G	A
rs13338499	24831852	181	AGRP	umls:C2267227	BeFree	AGRP rs13338499 polymorphism was associated with lowest illness-related BMI in those with AN (p = 0.0013), and NTRK2 rs1042571 was associated with highest BMI in those with BN (p = 0.0018).	0.000271442	2014	LOC101927837	16	67486220	A	G
rs13338499	24831852	4915	NTRK2	umls:C2267227	BeFree	AGRP rs13338499 polymorphism was associated with lowest illness-related BMI in those with AN (p = 0.0013), and NTRK2 rs1042571 was associated with highest BMI in those with BN (p = 0.0018).	0.000271442	2014	LOC101927837	16	67486220	A	G
rs142014203	23568457	286183	NKAIN3	umls:C2267227	GWASCAT	Genetic variants associated with disordered eating.	0.12	2013	NKAIN3	8	62346358	T	G
rs386602118	16901635	627	BDNF	umls:C2267227	BeFree	These results suggest that the 196G/A SNP of the human BDNF gene does not contribute to the genetic susceptibility to BN and BED, but may predispose those patients to a more severe binge eating behavior.	0.122442977	2006	NA	NA	NA	NA	NA
rs4680	25216558	1312	COMT	umls:C2267227	BeFree	Previous studies have shown that the met allele of the COMT val158met single nucleotide polymorphism (SNP) is associated with Bulimia Nervosa (BN).	0.000814326	2014	COMT;MIR4761	22	19963748	G	A
rs4680	21300128	1312	COMT	umls:C2267227	BeFree	COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa.	0.000814326	2011	COMT;MIR4761	22	19963748	G	A
rs53576	25773927	5021	OXTR	umls:C2267227	BeFree	Association between the oxytocin receptor gene polymorphism (rs53576) and bulimia nervosa.	0.000271442	2015	OXTR	3	8762685	A	G
rs696217	16472909	51738	GHRL	umls:C2267227	BeFree	No association of the Arg51Gln and Leu72Met polymorphisms of the ghrelin gene with anorexia nervosa or bulimia nervosa.	0.008715934	2006	GHRL;GHRLOS	3	10289773	G	T
rs77600076	23568457	140578	CHODL	umls:C2267227	GWASCAT	Genetic variants associated with disordered eating.	0.12	2013	CHODL	21	18159125	A	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:43)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	10341516	rs12131785	C	T	rs12131785	23568457	1.50E-05	NA	0.04	[0.022-0.062] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs12131785-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	23851787	rs3218148	G	A	rs3218148	23568457	1.97E-04	NA	0.03	[0.012-0.044] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs3218148-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	58319828	rs985795	T	G	rs985795	23568457	2.00E-06	NA	0.09	[0.055-0.133] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs985795-T	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	114226143	rs61742849	G	A	rs61742849	23568457	6.00E-06	NA	0.18	[0.1-0.26] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs61742849-G	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	225951441	rs12118223	A	T	rs12118223	23568457	6.34E-04	NA	0.06	[0.025-0.097] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs12118223-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	18834651	rs1445130	A	G	rs1445130	23568457	1.00E-07	NA	0.06	[0.036-0.076] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs1445130-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	42667585	rs1874449	T	G	rs1874449	23568457	6.30E-05	NA	0.03	[0.016-0.044] unit increase	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs1874449-T	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	53756542	rs56148675	T	C	rs56148675	23568457	5.00E-06	NA	0.08	[0.043-0.109] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs56148675-T	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	228506119	rs2396468	C	A	rs2396468	23568457	1.47E-04	NA	0.05	[0.022-0.07] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs2396468-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
3	38038982	rs6809649	T	C	rs6809649	23568457	2.44E-04	NA	0.04	[0.016-0.056] unit increase	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs6809649-T	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
3	133260874	rs11708304	C	T	rs11708304	23568457	6.00E-06	NA	0.06	[0.034-0.084] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs11708304-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
3	163855069	rs78661745	C	T	rs78661745	23568457	7.00E-06	NA	0.07	[0.039-0.097] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs78661745-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
4	31156178	rs74879986	G	A	rs74879986	23568457	6.00E-06	NA	0.14	[0.079-0.201] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs74879986-G	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
4	63893278	rs145379083	G	A	rs145379083	23568457	3.00E-06	NA	0.04	[0.021-0.053] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs145379083-G	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
4	88076129	rs115694618	A	G	rs115694618	23568457	4.00E-06	NA	0.12	[0.07-0.176] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs115694618-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
5	134321546	rs299362	G	A	rs299362	23568457	3.00E-06	NA	0.06	[0.037-0.087] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs299362-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
5	140679023	rs10491309	A	G	rs10491309	23568457	1.67E-04	NA	0.1	[0.045-0.145] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs10491309-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
5	150585867	rs7724774	G	A	rs7724774	23568457	7.00E-06	NA	0.05	[0.03-0.078] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs7724774-G	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
5	169273557	rs30080	G	C	rs30080	23568457	4.70E-05	NA	0.03	[0.016-0.044] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs30080-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
5	175559839	rs7443800	G	A	rs7443800	23568457	3.22E-04	NA	0.03	[0.013-0.041] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs7443800-G	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
5	177808675	rs2910124	C	T	rs2910124	23568457	6.00E-06	NA	0.06	[0.034-0.084] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs2910124-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
6	67653279	rs28631020	G	A	rs28631020	23568457	3.00E-06	NA	0.08	[0.047-0.113] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs28631020-G	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
6	138426032	rs1556640	C	T	rs1556640	23568457	2.00E-06	NA	0.08	[0.044-0.106] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs1556640-T	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	100283261	rs221795	C	T	rs221795	23568457	5.50E-05	NA	0.03	[0.015-0.043] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs221795-T	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	138794149	rs1814170	A	T	rs1814170	23568457	3.40E-05	NA	0.06	[0.028-0.084] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs1814170-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
8	10086411	rs6999631	G	C	rs6999631	23568457	8.00E-06	NA	0.09	[0.051-0.129] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs6999631-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
8	10086411	rs6999631	G	C	rs6999631	23568457	8.01E-06	NA	0.09	[0.05-0.13] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs6999631-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
8	63258917	rs142014203	T	G	rs142014203	23568457	9.00E-07	NA	0.13	[0.075-0.177] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs142014203-T	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
14	69703588	rs4902704	G	C	rs4902704	23568457	1.63E-04	NA	0.03	[0.014-0.042] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs4902704-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
14	99996774	rs4905848	G	A	rs4905848	23568457	9.78E-04	NA	0.03	[0.01-0.042] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs4905848-G	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
15	43655927	rs2412779	A	G	rs2412779	23568457	3.33E-04	NA	0.04	[0.019-0.067] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs2412779-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
15	74609378	rs2930313	A	G	rs2930313	23568457	1.23E-04	NA	0.06	[0.029-0.089] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs2930313-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
15	85699207	rs8040855	G	C	rs8040855	23568457	3.00E-06	NA	0.04	[0.021-0.049] unit increase	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs8040855-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
15	87710066	rs8024343	A	T	rs8024343	23568457	6.00E-06	NA	0.05	[0.025-0.065] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs8024343-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
16	11386960	rs117096873	C	T	rs117096873	23568457	2.00E-06	NA	0.13	[0.076-0.182] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs117096873-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
16	31523113	rs7187900	A	G	rs7187900	23568457	7.53E-04	NA	0.03	[0.011-0.039] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs7187900-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
16	69951291	rs904809	A	G	rs904809	23568457	4.30E-05	NA	0.03	[0.017-0.049] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs904809-G	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
19	29903677	rs12986207	G	A	rs12986207	23568457	4.00E-06	NA	0.04	[0.024-0.064] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs12986207-G	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
21	19531442	rs77600076	A	C	rs77600076	23568457	1.00E-06	NA	0.12	[0.075-0.173] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs77600076-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
21	27135562	rs10482968	C	A	rs10482968	23568457	2.41E-04	NA	0.04	[0.019-0.067] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs10482968-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
21	34369761	rs117124364	C	T	rs117124364	23568457	9.00E-06	NA	0.16	[0.089-0.231] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs117124364-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
22	31438361	rs111383589	C	T	rs111383589	23568457	2.00E-06	NA	0.09	[0.052-0.122] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs111383589-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
22	40800544	rs2235318	C	A,G,T	rs2235318	23568457	2.68E-04	NA	0.04	[0.017-0.057] unit decrease	151 female cases; 2,291 female controls	NOPOP(2442)	ALL(2442)	NOPOP(2442)	ALL(2442)	Bulimia nervosa	HPOID:0100739	Bulimia	DOID:12129	bulimia nervosa	NA	NA	NA	NA	Eating disorder	rs2235318-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:4)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C2267227	clozapine	D003024	5786-21-0	bulimia nervosa	MESH:D052018	marker/mechanism	17372672
C2267227	fluoxetine	D005473	54910-89-3	bulimia nervosa	MESH:D052018	therapeutic	11772696
C2267227	fluvoxamine	D016666	54739-18-3	bulimia nervosa	MESH:D052018	therapeutic	15763129
C2267227	olanzapine	C076029	132539-06-1	bulimia nervosa	MESH:D052018	marker/mechanism	17372672

FDA approved drug and dosage information(Total Drugs:4)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D052018	zyprexa	olanzapine	2.5MG	TABLET;ORAL	Prescription	AB	Yes	No
MESH:D052018	zyprexa	olanzapine	10MG/VIAL	INJECTABLE;INTRAMUSCULAR	Prescription	AP	Yes	Yes
MESH:D052018	zyprexa	olanzapine	2.5MG	TABLET;ORAL	Prescription	AB	Yes	No
MESH:D052018	zyprexa	olanzapine	10MG/VIAL	INJECTABLE;INTRAMUSCULAR	Prescription	AP	Yes	Yes

FDA labeling changes(Total Drugs:4)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D052018	08/14/2008	zyprexa	olanzapine	schizophrenia; bipolar disorder	Safety and effectiveness have not been established for patients less than 18 years of age In an analysis of placebo-controlled olanzapine monotherapy studies of adolescent patients, including those with schizophrenia or bipolar disorder, olanzapine was associated with: oHyperglycemia - a statistically significantly greater mean change in fasting glucose levels compared to placebo oHyperlipidemia statistically significant increases compared to placebo in fasting triglycerides, fasting total cholesterol and fasting LDL cholesterol oWeight gain olanzapine treated patients gained an average of 4.6 kg, compared to an average of 0.3 kg in placebo-treated patients with a median exposure of 3 weeks; Average weight gain during long-term therapy was 7.4 kg	-	B	-	-	-	Lilly	10/1/2007	FALSE'
MESH:D052018	08/14/2008	zyprexa	olanzapine	schizophrenia; bipolar disorder	Safety and effectiveness have not been established for patients less than 18 years of age In an analysis of placebo-controlled olanzapine monotherapy studies of adolescent patients, including those with schizophrenia or bipolar disorder, olanzapine was associated with: oHyperglycemia - a statistically significantly greater mean change in fasting glucose levels compared to placebo oHyperlipidemia statistically significant increases compared to placebo in fasting triglycerides, fasting total cholesterol and fasting LDL cholesterol oWeight gain olanzapine treated patients gained an average of 4.6 kg, compared to an average of 0.3 kg in placebo-treated patients with a median exposure of 3 weeks; Average weight gain during long-term therapy was 7.4 kg	-	B	-	-	-	Lilly	10/1/2007	FALSE'
MESH:D052018	4/12/2009	zyprexa	olanzapine	Treatment of manic or mixed episodes of bipolar I disorder and schizophrenia in adolescents ages 13-17	Extended schizophrenia and manic or mixed episodes of bipolar I disorder indications from adults to adolescents 1317 years of age Safety and effectiveness in children < 13 years of age have not been established Recommended starting dose for adolescents is lower than that for adults Compared to patients from adult clinical trials, adolescents were likely to gain more weight, experience increased sedation, and have greater increases in total cholesterol, triglycerides, LDL cholesterol, prolactin and hepatic transaminase levels Information on dosing, adverse reactions, pharmacokinetics, clinical studies	Labeling	B	-	-	-	Lilly	10/1/2007	TRUE'
MESH:D052018	4/12/2009	zyprexa	olanzapine	Treatment of manic or mixed episodes of bipolar I disorder and schizophrenia in adolescents ages 13-17	Extended schizophrenia and manic or mixed episodes of bipolar I disorder indications from adults to adolescents 1317 years of age Safety and effectiveness in children < 13 years of age have not been established Recommended starting dose for adolescents is lower than that for adults Compared to patients from adult clinical trials, adolescents were likely to gain more weight, experience increased sedation, and have greater increases in total cholesterol, triglycerides, LDL cholesterol, prolactin and hepatic transaminase levels Information on dosing, adverse reactions, pharmacokinetics, clinical studies	Labeling	B	-	-	-	Lilly	10/1/2007	TRUE'