PedAM

Pediatric Disease Annotations & Medicines


	brugada syndrome

Disease ID	30
Disease	brugada syndrome
Definition	An autosomal dominant defect of cardiac conduction that is characterized by an abnormal ST-segment in leads V1-V3 on the ELECTROCARDIOGRAM resembling a right BUNDLE-BRANCH BLOCK; high risk of VENTRICULAR TACHYCARDIA; or VENTRICULAR FIBRILLATION; SYNCOPAL EPISODE; and possible sudden death. This syndrome is linked to mutations of gene encoding the cardiac SODIUM CHANNEL alpha subunit.
Synonym	brgda1 brugada syndrome (disorder) brugada syndrome 1 brugada syndrome [disease/finding] brugada syndrome ventricular arrhythmia brugada syndrome ventricular arrhythmia by ecg finding brugada syndrome ventricular arrhythmia by ekg finding brugadas syndrome right bundle branch block, st segment elevation, and sudden death syndrome sudden unexplained nocturnal death syndrome sunds ventricular arrhythmia associated with brugada syndrome
Orphanet	ORPHANET:130
OMIM	OMIM:601144
DOID	DOID:0050451
UMLS	C1142166
MeSH	D053840
SNOMED-CT	SNOMEDCT_US_2016_09_01:418818005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:13) C0085615 \| right bundle branch block \| 2 C0006384 \| bundle branch block \| 2 C0011570 \| depression \| 1 C0878544 \| cardiomyopathy \| 1 C0027051 \| myocardial infarction \| 1 C0003467 \| anxiety \| 1 C0018799 \| heart disease \| 1 C0917996 \| cerebral aneurysm \| 1 C0037052 \| sick sinus syndrome \| 1 C0043202 \| wpw syndrome \| 1 C0152021 \| congenital heart disease \| 1 C0027051 \| myocardial infarct \| 1 C0037315 \| sleep-disordered breathing \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:17) CACNA1C \| 775 \| CLINVAR;ORPHANET;GHR;UniProtKB-KW SCN1B \| 6324 \| CTD_human;ORPHANET;GHR;UniProtKB-KW CACNB2 \| 783 \| ORPHANET;GHR;UniProtKB-KW HCN4 \| 10021 \| ORPHANET;GHR;UniProtKB-KW KCND3 \| 3752 \| ORPHANET;GHR;UniProtKB-KW KCNE3 \| 10008 \| CLINVAR;ORPHANET;GHR;UniProtKB-KW TRPM4 \| 54795 \| ORPHANET;GHR KCNJ8 \| 3764 \| ORPHANET;GHR SCN3B \| 55800 \| CLINVAR;ORPHANET;GHR;UniProtKB-KW SCN5A \| 6331 \| CLINVAR;GWASCAT;GHR;UniProtKB-KW;ORPHANET;UNIPROT;CTD_human SCN10A \| 6336 \| CTD_human;ORPHANET;GWASCAT GPD1L \| 23171 \| ORPHANET;GHR;UniProtKB-KW SCN2B \| 6327 \| UniProtKB-KW;GHR CACNA2D1 \| 781 \| ORPHANET;GHR HEY2 \| 23493 \| CTD_human SLMAP \| 7871 \| ORPHANET;GHR RANGRF \| 29098 \| GHR
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:6) 23171 \| GPD1L \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 6324 \| SCN1B \| infer 6327 \| SCN2B \| infer 6331 \| SCN5A \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:111) 5318 \| PKP2 \| DISEASES 3784 \| KCNQ1 \| DISEASES 6640 \| SNTA1 \| DISEASES 29098 \| RANGRF \| DISEASES 6783 \| SULT1E1 \| DISEASES 3111 \| HLA-DOA \| DISEASES 50805 \| IRX4 \| DISEASES 9631 \| NUP155 \| DISEASES 6909 \| TBX2 \| DISEASES 3764 \| KCNJ8 \| DISEASES 3759 \| KCNJ2 \| DISEASES 3024 \| HIST1H1A \| DISEASES 821 \| CANX \| DISEASES 54795 \| TRPM4 \| DISEASES 10060 \| ABCC9 \| DISEASES 4331 \| MNAT1 \| DISEASES 845 \| CASQ2 \| DISEASES 1829 \| DSG2 \| DISEASES 10021 \| HCN4 \| DISEASES 3757 \| KCNH2 \| DISEASES 10371 \| SEMA3A \| DISEASES 3746 \| KCNC1 \| DISEASES 775 \| CACNA1C \| DISEASES 7168 \| TPM1 \| DISEASES 80816 \| ASXL3 \| DISEASES 3779 \| KCNMB1 \| DISEASES 4851 \| NOTCH1 \| DISEASES 23082 \| PPRC1 \| DISEASES 6327 \| SCN2B \| DISEASES 288 \| ANK3 \| DISEASES 1824 \| DSC2 \| DISEASES 23704 \| KCNE4 \| DISEASES 23037 \| PDZD2 \| DISEASES 23171 \| GPD1L \| DISEASES 6328 \| SCN3A \| DISEASES 3773 \| KCNJ16 \| DISEASES 1562 \| CYP2C18 \| DISEASES 51422 \| PRKAG2 \| DISEASES 9992 \| KCNE2 \| DISEASES 79190 \| IRX6 \| DISEASES 7871 \| SLMAP \| DISEASES 8927 \| BSN \| DISEASES 55800 \| SCN3B \| DISEASES 2819 \| GPD1 \| DISEASES 79188 \| TMEM43 \| DISEASES 79192 \| IRX1 \| DISEASES 121391 \| KRT74 \| DISEASES 11280 \| SCN11A \| DISEASES 1540 \| CYLD \| DISEASES 171389 \| NLRP6 \| DISEASES 10008 \| KCNE3 \| DISEASES 3728 \| JUP \| DISEASES 5553 \| PRG2 \| DISEASES 3752 \| KCND3 \| DISEASES 783 \| CACNB2 \| DISEASES 6330 \| SCN4B \| DISEASES 3739 \| KCNA4 \| DISEASES 6331 \| SCN5A \| DISEASES 79191 \| IRX3 \| DISEASES 6546 \| SLC8A1 \| DISEASES 3751 \| KCND2 \| DISEASES 2626 \| GATA4 \| DISEASES 3753 \| KCNE1 \| DISEASES 1180 \| CLCN1 \| DISEASES 3762 \| KCNJ5 \| DISEASES 859 \| CAV3 \| DISEASES 3767 \| KCNJ11 \| DISEASES 1739 \| DLG1 \| DISEASES 331 \| XIAP \| DISEASES 10142 \| AKAP9 \| DISEASES 781 \| CACNA2D1 \| DISEASES 287 \| ANK2 \| DISEASES 23607 \| CD2AP \| DISEASES 6337 \| SCNN1A \| DISEASES 1825 \| DSC3 \| DISEASES 4519 \| MT-CYB \| DISEASES 9722 \| NOS1AP \| DISEASES 376132 \| LRRC10 \| DISEASES 7179 \| TPTE \| DISEASES 6262 \| RYR2 \| DISEASES 3775 \| KCNK1 \| DISEASES 3664 \| IRF6 \| DISEASES 89796 \| NAV1 \| DISEASES 23493 \| HEY2 \| DISEASES 5950 \| RBP4 \| DISEASES 57582 \| KCNT1 \| DISEASES 1678 \| TIMM8A \| DISEASES 57158 \| JPH2 \| DISEASES 4920 \| ROR2 \| DISEASES 2259 \| FGF14 \| DISEASES 5293 \| PIK3CD \| DISEASES 116085 \| SLC22A12 \| DISEASES 22894 \| DIS3 \| DISEASES 1804 \| DPP6 \| DISEASES 8514 \| KCNAB2 \| DISEASES 1832 \| DSP \| DISEASES 5901 \| RAN \| DISEASES 10265 \| IRX5 \| DISEASES 6332 \| SCN7A \| DISEASES 6336 \| SCN10A \| DISEASES 6329 \| SCN4A \| DISEASES 6324 \| SCN1B \| DISEASES 2935 \| GSPT1 \| DISEASES 2257 \| FGF12 \| DISEASES 23089 \| PEG10 \| DISEASES 9254 \| CACNA2D2 \| DISEASES 30819 \| KCNIP2 \| DISEASES 7419 \| VDAC3 \| DISEASES 9312 \| KCNB2 \| DISEASES 400410 \| ST20 \| DISEASES 102723508 \| KANTR \| DISEASES
Locus	Symbol \| Locus(Total Locus:14) KCND3 \| 1p13.2 CACNA1C \| 12p13.33 KCNE3 \| 11q13.4 SCN1B \| 19q13.11 CACNB2 \| 10p12 CACNA2D1 \| 7q21.11 SCN5A \| 3p22.2 TRPM4 \| 19q13.3 GPD1L \| 3p22.3 SCN10A \| 3p22.2 HCN4 \| 15q24.1 SCN3B \| 11q24.1 SLMAP \| 3p14.3 KCNJ8 \| 12p12.1

Disease ID	30
Disease	brugada syndrome
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:2) HP:0001663 \| Ventricular fibrillation HP:0001695 \| Cardiac arrest
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:29) HP:0001663 \| Ventricular fibrillation \| 22 HP:0011675 \| Arrhythmias \| 18 HP:0004308 \| Ventricular arrhythmia \| 12 HP:0004756 \| Ventricular tachycardia \| 9 HP:0001279 \| Syncope \| 8 HP:0001649 \| Tachycardia \| 5 HP:0001645 \| Sudden cardiac death \| 5 HP:0012272 \| Osborne waves \| 4 HP:0005110 \| Atrial fibrillation \| 3 HP:0001945 \| Fever \| 3 HP:0001695 \| Cardiac arrest \| 3 HP:0011710 \| Bundle-branch block \| 2 HP:0011712 \| Right bundle-branch block \| 2 HP:0001631 \| Atria septal defect \| 1 HP:0007185 \| Loss of consciousness \| 1 HP:0012668 \| Situational syncope \| 1 HP:0004944 \| Cerebral artery aneurysm \| 1 HP:0001658 \| Myocardial infarction \| 1 HP:0000716 \| Depression \| 1 HP:0004749 \| Atrial flutter \| 1 HP:0011704 \| Sick sinus syndrome \| 1 HP:0002459 \| Dysautonomia \| 1 HP:0005115 \| arrhythmias, Supraventricular \| 1 HP:0004755 \| Supraventricular tachycardia \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0000739 \| Anxiety \| 1 HP:0012251 \| ST segment elevation \| 1 HP:0011947 \| Respiratory infection \| 1 HP:0002617 \| Aneurysmal dilatation \| 1

Disease ID	30
Disease	brugada syndrome
Manually Symptom	UMLS \| Name(Total Manually Symptoms:14) C2712322 \| tachycardia C2700501 \| wolff-parkinson-white syndrome C2347963 \| right ventricular outflow tract tachycardia C2108112 \| ventricular fibrillation C1962971 \| myocarditis C1145628 \| disorders of the autonomic nervous system C0743841 \| febrile illness C0684249 \| lung cancer C0344432 \| polymorphic ventricular tachycardia C0344431 \| monomorphic ventricular tachycardia C0340850 \| neurally mediated syncope C0235480 \| paroxysmal atrial fibrillation C0232197 \| fibrillation C0039070 \| syncope
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:7) C0232197 \| fibrillation \| 27 C0042510 \| ventricular fibrillation \| 22 C0039070 \| syncope \| 8 C0039231 \| tachycardia \| 5 C0344431 \| monomorphic ventricular tachycardia \| 3 C0344432 \| polymorphic ventricular tachycardia \| 2 C1145628 \| disorders of the autonomic nervous system \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:288)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10428132	24667784	6331	SCN5A	umls:C1142166	BeFree	We investigated whether three single-nucleotide polymorphisms (SNPs) (rs11708996; G>C located intronic to SCN5A, rs10428132; T>G located in SCN10A, and rs9388451; T>C located downstream to HEY2) at loci associated with BrS in a recent genome-wide association study (GWAS) also were associated with AF.	0.837036084	2013	SCN10A	3	38736063	T	G
rs10428132	23872634	6336	SCN10A	umls:C1142166	GWASCAT	Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.	0.361357209	2013	SCN10A	3	38736063	T	G
rs10428132	24667784	23493	HEY2	umls:C1142166	BeFree	We investigated whether three single-nucleotide polymorphisms (SNPs) (rs11708996; G>C located intronic to SCN5A, rs10428132; T>G located in SCN10A, and rs9388451; T>C located downstream to HEY2) at loci associated with BrS in a recent genome-wide association study (GWAS) also were associated with AF.	0.120542884	2013	SCN10A	3	38736063	T	G
rs10428132	24667784	6336	SCN10A	umls:C1142166	BeFree	We investigated whether three single-nucleotide polymorphisms (SNPs) (rs11708996; G>C located intronic to SCN5A, rs10428132; T>G located in SCN10A, and rs9388451; T>C located downstream to HEY2) at loci associated with BrS in a recent genome-wide association study (GWAS) also were associated with AF.	0.361357209	2013	SCN10A	3	38736063	T	G
rs11708996	23872634	6331	SCN5A	umls:C1142166	GWASCAT	Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.	0.837036084	2013	SCN5A	3	38592432	G	C
rs11708996	24667784	6331	SCN5A	umls:C1142166	BeFree	We investigated whether three single-nucleotide polymorphisms (SNPs) (rs11708996; G>C located intronic to SCN5A, rs10428132; T>G located in SCN10A, and rs9388451; T>C located downstream to HEY2) at loci associated with BrS in a recent genome-wide association study (GWAS) also were associated with AF.	0.837036084	2013	SCN5A	3	38592432	G	C
rs11708996	24667784	23493	HEY2	umls:C1142166	BeFree	We investigated whether three single-nucleotide polymorphisms (SNPs) (rs11708996; G>C located intronic to SCN5A, rs10428132; T>G located in SCN10A, and rs9388451; T>C located downstream to HEY2) at loci associated with BrS in a recent genome-wide association study (GWAS) also were associated with AF.	0.120542884	2013	SCN5A	3	38592432	G	C
rs11708996	24667784	6336	SCN10A	umls:C1142166	BeFree	We investigated whether three single-nucleotide polymorphisms (SNPs) (rs11708996; G>C located intronic to SCN5A, rs10428132; T>G located in SCN10A, and rs9388451; T>C located downstream to HEY2) at loci associated with BrS in a recent genome-wide association study (GWAS) also were associated with AF.	0.361357209	2013	SCN5A	3	38592432	G	C
rs121908441	NA	10008	KCNE3	umls:C1142166	CLINVAR	NA	0.24	NA	KCNE3	11	74457268	C	T
rs121912775	NA	775	CACNA1C	umls:C1142166	CLINVAR	NA	0.244895885	NA	CACNA1C	12	2550020	G	A
rs121912776	NA	775	CACNA1C	umls:C1142166	CLINVAR	NA	0.244895885	NA	CACNA1C	12	2115290	C	T
rs121912776	24775099	801	CALM1	umls:C1142166	BeFree	Effect of the Brugada syndrome mutation A39V on calmodulin regulation of Cav1.2 channels.	0.000542884	2014	CACNA1C	12	2115290	C	T
rs121912776	22385640	775	CACNA1C	umls:C1142166	BeFree	The Brugada syndrome mutation A39V does not affect surface expression of neuronal rat Cav1.2 channels.	0.244895885	2012	CACNA1C	12	2115290	C	T
rs121912776	24775099	805	CALM2	umls:C1142166	BeFree	Effect of the Brugada syndrome mutation A39V on calmodulin regulation of Cav1.2 channels.	0.000542884	2014	CACNA1C	12	2115290	C	T
rs121912776	24775099	775	CACNA1C	umls:C1142166	BeFree	Effect of the Brugada syndrome mutation A39V on calmodulin regulation of Cav1.2 channels.	0.244895885	2014	CACNA1C	12	2115290	C	T
rs121912776	24775099	808	CALM3	umls:C1142166	BeFree	Effect of the Brugada syndrome mutation A39V on calmodulin regulation of Cav1.2 channels.	0.000542884	2014	CACNA1C	12	2115290	C	T
rs121918282	NA	55800	SCN3B	umls:C1142166	CLINVAR	NA	0.240814326	NA	SCN3B;LOC105369543	11	123653773	A	G
rs12720452	11997281	6331	SCN5A	umls:C1142166	UNIPROT	Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes.	0.837036084	2002	SCN5A	3	38603758	C	T
rs12720452	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38603758	C	T
rs137854603	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38550602	C	T
rs137854609	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38581170	C	T,A
rs137854611	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38597787	G	T,A
rs137854612	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560170	C	T
rs137854614	11410597	2042	EPHA3	umls:C1142166	BeFree	We report the analysis of two novel mutations on the same codon, Y1795C (LQT-3) and Y1795H (BrS), expressed in HEK 293 cells and characterized using whole-cell patch clamp procedures.	0.000271442	2001	SCN5A	3	38550988	T	C
rs137854614	16929919	6331	SCN5A	umls:C1142166	BeFree	Recently, two novel missense mutations at the same codon in the gene encoding the cardiac Na+ channel (SCN5A) have been identified: Y1795C (causing the LQTS phenotype) and Y1795H (causing the BrS phenotype).	0.837036084	2006	SCN5A	3	38550988	T	C
rs137854615	16929919	6331	SCN5A	umls:C1142166	BeFree	Recently, two novel missense mutations at the same codon in the gene encoding the cardiac Na+ channel (SCN5A) have been identified: Y1795C (causing the LQTS phenotype) and Y1795H (causing the BrS phenotype).	0.837036084	2006	SCN5A	3	38550989	A	G
rs137854615	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38550989	A	G
rs137854615	11410597	2042	EPHA3	umls:C1142166	BeFree	We report the analysis of two novel mutations on the same codon, Y1795C (LQT-3) and Y1795H (BrS), expressed in HEK 293 cells and characterized using whole-cell patch clamp procedures.	0.000271442	2001	SCN5A	3	38550989	A	G
rs137854616	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38566465	C	T
rs137854617	15579534	6331	SCN5A	umls:C1142166	BeFree	Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes.	0.837036084	2004	SCN5A	3	38581002	C	T
rs137854618	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38566426	C	T,A
rs146848219	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38604004	C	T
rs185492581	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38630327	T	C
rs193922726	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551188	G	C,A
rs199473042	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38633304	C	T
rs199473050	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38633098	A	C
rs199473051	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38633058	C	T
rs199473052	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38630425	A	G
rs199473053	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38630422	A	C
rs199473054	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38630420	C	T,G
rs199473054	24529773	6331	SCN5A	umls:C1142166	BeFree	Three SCN5A mutations (V95I, R121Q, and R367H) have been previously implicated in BrS.	0.837036084	2013	SCN5A	3	38630420	C	T,G
rs199473055	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38630393	G	C,A
rs199473056	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38630376	G	T,A
rs199473058	24529773	6331	SCN5A	umls:C1142166	BeFree	Three SCN5A mutations (V95I, R121Q, and R367H) have been previously implicated in BrS.	0.837036084	2013	SCN5A	3	38630341	C	T
rs199473058	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38630341	C	T
rs199473061	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38622446	C	T
rs199473062	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38622401	C	T,G
rs199473063	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38620929	C	G
rs199473065	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38620921	G	C
rs199473066	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38620910	A	G
rs199473067	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38620900	G	A
rs199473070	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38613811	A	T,G
rs199473074	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38613758	T	C
rs199473076	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38609950	C	T
rs199473079	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38609860	G	T
rs199473081	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38609841	A	T
rs199473082	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38609824	G	A
rs199473083	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38609823	C	T
rs199473085	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38609794	C	T
rs199473086	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38609788	C	T
rs199473088	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38609770	C	T
rs199473089	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38608198	C	G
rs199473090	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38608194	C	T
rs199473091	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38608190	G	T
rs199473092	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38608175	A	C
rs199473093	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38606802	G	A
rs199473095	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38606757	C	T,A
rs199473096	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38606751	G	A
rs199473096	25261036	6331	SCN5A	umls:C1142166	BeFree	Electrophysiological and trafficking defects of the SCN5A T353I mutation in Brugada syndrome are rescued by alpha-allocryptopine.	0.837036084	2014	SCN5A	3	38606751	G	A
rs199473096	17198989	6331	SCN5A	umls:C1142166	BeFree	We have identified a novel threonine-to-isoleucine missense mutation at position 353 (T353I) adjacent to the pore-lining region of domain I of the cardiac sodium channel (SCN5A) in a family with Brugada syndrome.	0.837036084	2007	SCN5A	3	38606751	G	A
rs199473098	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38606703	A	T
rs199473101	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38606682	C	T
rs199473102	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38606133	C	T
rs199473103	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38606102	A	G
rs199473104	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38606103	C	G
rs199473117	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38604745	T	C
rs199473122	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38603973	A	T
rs199473123	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38603939	C	T
rs199473124	11123251	6331	SCN5A	umls:C1142166	BeFree	A missense mutation of SCN5A that substitutes glutamine for leucine at codon 567 (L567Q, in the cytoplasmic linker between domains I and II) is identified with sudden infant death and Brugada syndrome in one family.	0.837036084	2001	SCN5A	3	38603902	A	T
rs199473124	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38603902	A	T
rs199473129	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38603846	C	T
rs199473133	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38603747	G	A
rs199473134	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38599046	G	A
rs199473137	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38599023	G	C,A
rs199473139	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38598960	G	A
rs199473143	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38597949	T	G
rs199473144	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38597944	A	G,C
rs199473149	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38597841	G	A
rs199473151	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38597788	C	T
rs199473153	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38597737	C	T
rs199473154	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38587563	C	T
rs199473156	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38587545	A	G,C
rs199473158	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38587519	G	A
rs199473159	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38587471	C	T
rs199473163	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585974	G	A
rs199473164	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585962	A	G
rs199473167	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585879	C	G
rs199473168	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585846	G	A
rs199473169	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585821	T	G
rs199473170	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585804	A	T
rs199473171	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585801	G	A
rs199473172	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585800	C	T,A
rs199473173	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585792	A	T
rs199473174	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585777	C	T
rs199473175	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585749	G	A
rs199473176	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585728	A	C
rs199473178	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585695	A	G
rs199473179	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38581355	A	G
rs199473180	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38581266	G	C,A
rs199473181	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38581265	C	T,A
rs199473188	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38579488	G	T,A
rs199473194	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38579386	G	A
rs199473199	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38576753	C	G
rs199473205	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38566567	A	G
rs199473206	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38566554	C	T
rs199473207	18503232	6331	SCN5A	umls:C1142166	BeFree	Absence of a trafficking defect in R1232W/T1620M, a double SCN5A mutant responsible for Brugada syndrome.	0.837036084	2008	SCN5A	3	38566555	G	A
rs199473207	11786529	6331	SCN5A	umls:C1142166	BeFree	Expression and intracellular localization of an SCN5A double mutant R1232W/T1620M implicated in Brugada syndrome.	0.837036084	2002	SCN5A	3	38566555	G	A
rs199473207	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38566555	G	A
rs199473208	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38566541	C	A
rs199473209	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38566542	T	C
rs199473210	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38566533	A	G
rs199473211	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38566531	C	G
rs199473213	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38566503	A	T
rs199473214	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38566491	T	C
rs199473217	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38562515	G	C
rs199473219	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38562446	A	G
rs199473220	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38562422	C	A
rs199473221	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560424	A	C
rs199473225	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560397	G	C,A
rs199473228	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560362	A	G
rs199473229	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560361	A	G
rs199473230	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560356	G	T
rs199473231	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560355	A	G
rs199473232	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560340	A	C
rs199473233	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560335	C	T
rs199473234	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560320	C	A
rs199473235	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560315	C	T,A
rs199473236	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560313	A	C
rs199473237	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560304	C	T
rs199473238	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560252	G	C
rs199473239	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560179	C	T,G
rs199473240	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560176	C	T
rs199473241	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560158	G	A
rs199473242	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38557275	T	C
rs199473243	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38557271	C	A
rs199473244	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38557251	C	A
rs199473245	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38557236	T	C
rs199473245	11420310	6331	SCN5A	umls:C1142166	BeFree	Novel mechanism for Brugada syndrome: defective surface localization of an SCN5A mutant (R1432G).	0.837036084	2001	SCN5A	3	38557236	T	C
rs199473247	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38557232	C	T,A
rs199473248	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38556565	G	A
rs199473249	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38556557	C	G
rs199473250	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38556536	T	G
rs199473251	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38556535	A	G
rs199473252	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38556526	A	T
rs199473254	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38556476	C	A
rs199473261	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38555718	A	T
rs199473266	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38555697	G	C
rs199473267	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38555694	C	T
rs199473269	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38554519	C	T
rs199473270	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38554512	T	C
rs199473271	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38554450	C	T
rs199473272	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38554435	T	G
rs199473273	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38554387	C	G
rs199473274	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38554380	A	C
rs199473275	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38554347	A	G
rs199473280	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38554282	C	T
rs199473281	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551534	T	A
rs199473282	10664447	6331	SCN5A	umls:C1142166	BeFree	SCN5A mutation (T1620M) causing Brugada syndrome exhibits different phenotypes when expressed in Xenopus oocytes and mammalian cells.	0.837036084	2000	SCN5A	3	38551513	G	T,A
rs199473282	11029409	6331	SCN5A	umls:C1142166	BeFree	The biophysical properties of the SCN5A mutation T1620M associated with Brugada syndrome were examined for defects in intermediate inactivation (I:(M)), a gating process in Na(+) channels with kinetic features intermediate between fast and slow inactivation.	0.837036084	2000	SCN5A	3	38551513	G	T,A
rs199473282	11786529	6331	SCN5A	umls:C1142166	BeFree	Expression and intracellular localization of an SCN5A double mutant R1232W/T1620M implicated in Brugada syndrome.	0.837036084	2002	SCN5A	3	38551513	G	T,A
rs199473282	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551513	G	T,A
rs199473282	18503232	6331	SCN5A	umls:C1142166	BeFree	Absence of a trafficking defect in R1232W/T1620M, a double SCN5A mutant responsible for Brugada syndrome.	0.837036084	2008	SCN5A	3	38551513	G	T,A
rs199473284	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551487	G	C,A
rs199473289	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551426	G	A
rs199473292	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551391	C	T,G
rs199473294	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551334	C	T
rs199473295	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551280	C	T
rs199473296	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551254	C	G
rs199473297	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551246	G	C,A
rs199473298	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551238	C	T
rs199473299	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551208	T	C
rs199473299	23085483	6331	SCN5A	umls:C1142166	BeFree	p.D1690N Nav1.5 rescues p.G1748D mutation gating defects in a compound heterozygous Brugada syndrome patient.	0.837036084	2013	SCN5A	3	38551208	T	C
rs199473302	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551190	A	G
rs199473304	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551154	C	T
rs199473305	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551145	C	T
rs199473309	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551082	C	A
rs199473313	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551051	T	C
rs199473315	24599044	6331	SCN5A	umls:C1142166	BeFree	Flecainide provocation reveals concealed brugada syndrome in a long QT syndrome family with a novel L1786Q mutation in SCN5A.	0.837036084	2015	SCN5A	3	38551015	A	T
rs199473318	23085483	6331	SCN5A	umls:C1142166	BeFree	p.D1690N Nav1.5 rescues p.G1748D mutation gating defects in a compound heterozygous Brugada syndrome patient.	0.837036084	2013	SCN5A	3	38550967	T	C
rs199473320	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38550878	G	C
rs199473322	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38550823	C	G
rs199473322	18252757	6331	SCN5A	umls:C1142166	BeFree	Analyses of a novel SCN5A mutation (C1850S): conduction vs. repolarization disorder hypotheses in the Brugada syndrome.	0.837036084	2008	SCN5A	3	38550823	C	G
rs199473323	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38550756	C	G
rs199473329	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38550560	C	T,A
rs199473332	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38550481	G	A
rs199473340	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585925	G	T
rs199473391	NA	775	CACNA1C	umls:C1142166	CLINVAR	NA	0.244895885	NA	CACNA1C	12	2607117	G	A
rs199473392	NA	775	CACNA1C	umls:C1142166	CLINVAR	NA	0.244895885	NA	CACNA1C;CACNA1C-AS1	12	2691170	G	A,T
rs199473550	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38633305	C	T
rs199473552	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38633205	C	T
rs199473554	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38630392	C	T
rs199473556	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38630342	G	A
rs199473557	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38622475	A	G
rs199473558	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38620894	G	C,A
rs199473559	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38620843	G	T,A
rs199473560	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38613779	C	G
rs199473561	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38613769	G	A
rs199473562	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38609836	G	C
rs199473564	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38608205	A	G
rs199473565	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38606743	C	T
rs199473566	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38606689	A	C
rs199473567	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38606132	C	T
rs199473568	17445919	6331	SCN5A	umls:C1142166	BeFree	A paradoxical effect of lidocaine for the N406S mutation of SCN5A associated with Brugada syndrome.	0.837036084	2007	SCN5A	3	38606072	T	C
rs199473568	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38606072	T	C
rs199473570	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38605974	C	T
rs199473573	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38604007	A	C
rs199473574	16155735	6331	SCN5A	umls:C1142166	BeFree	We also identified the SCN5A A551T mutation in 1 of the 28 patients with Brugada syndrome.	0.837036084	2005	SCN5A	3	38603951	C	T
rs199473574	19706159	6331	SCN5A	umls:C1142166	BeFree	Characterization of a novel Nav1.5 channel mutation, A551T, associated with Brugada syndrome.	0.837036084	2009	SCN5A	3	38603951	C	T
rs199473574	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38603951	C	T
rs199473577	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38603744	G	A
rs199473582	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38597755	C	T
rs199473584	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38586037	C	T
rs199473586	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585927	A	G
rs199473587	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585845	C	T
rs199473588	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585735	A	G
rs199473589	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585698	T	C
rs199473592	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38581091	C	T,G
rs199473593	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38580995	T	C
rs199473597	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38575307	C	T
rs199473599	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38566522	C	T
rs199473601	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38566436	C	G
rs199473602	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38562537	C	A
rs199473605	19648062	6331	SCN5A	umls:C1142166	BeFree	A novel SCN5A mutation V1340I in Brugada syndrome augmenting arrhythmias during febrile illness.	0.837036084	2009	SCN5A	3	38560374	C	T
rs199473605	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560374	C	T
rs199473606	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560357	C	T,A
rs199473607	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560343	A	G
rs199473608	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560247	C	A
rs199473609	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560175	C	T
rs199473610	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38560166	T	C
rs199473611	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38557272	C	G
rs199473612	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38557247	G	A
rs199473613	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38556532	T	C
rs199473614	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38556491	T	A
rs199473617	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38554530	A	T,G
rs199473620	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38554372	C	T
rs199473621	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38554344	C	T
rs199473623	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551486	C	T
rs199473623	24167619	6331	SCN5A	umls:C1142166	BeFree	Electrophysiological characteristics of a SCN5A voltage sensors mutation R1629Q associated with Brugada syndrome.	0.837036084	2013	SCN5A	3	38551486	C	T
rs199473624	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551447	C	T
rs199473625	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551394	T	C
rs199473626	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551357	G	T
rs199473628	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551231	T	C
rs199473629	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551144	C	T
rs199473634	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38551036	G	A
rs199473636	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38550791	C	T
rs199473637	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38550569	C	T
rs199473639	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38550469	A	T,C
rs200034939	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38557248	C	A
rs201641342	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38603950	G	A
rs28936971	11748104	6331	SCN5A	umls:C1142166	UNIPROT	Novel SCN5A mutation leading either to isolated cardiac conduction defect or Brugada syndrome in a large French family.	0.837036084	2001	NA	NA	NA	NA	NA
rs28937318	24529773	6331	SCN5A	umls:C1142166	BeFree	Three SCN5A mutations (V95I, R121Q, and R367H) have been previously implicated in BrS.	0.837036084	2013	SCN5A	3	38606709	C	T,A
rs28937318	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38606709	C	T,A
rs28937318	12106943	6331	SCN5A	umls:C1142166	UNIPROT	Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients.	0.837036084	2002	SCN5A	3	38606709	C	T,A
rs28937318	11823453	6331	SCN5A	umls:C1142166	UNIPROT	We screened patients with SUNDS for mutations in SCN5A, the gene known to cause Brugada syndrome, as well as genes encoding ion channels associated with the long-QT syndrome.	0.837036084	2002	SCN5A	3	38606709	C	T,A
rs370438420	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38613836	T	C
rs3918389	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38603948	C	T,G,A
rs3918389	12358675	6331	SCN5A	umls:C1142166	UNIPROT	SCN5A is expressed in human jejunal circular smooth muscle cells.	0.837036084	2002	SCN5A	3	38603948	C	T,G,A
rs41261344	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38575385	C	T
rs41261344	15851440	6331	SCN5A	umls:C1142166	BeFree	DNA analysis revealed a missense mutation (R1193Q) in the SCN5A gene, previously linked with familial sudden unexpected nocturnal death syndrome, also known as Brugada syndrome.	0.837036084	2005	SCN5A	3	38575385	C	T
rs41261344	11823453	6331	SCN5A	umls:C1142166	UNIPROT	We screened patients with SUNDS for mutations in SCN5A, the gene known to cause Brugada syndrome, as well as genes encoding ion channels associated with the long-QT syndrome.	0.837036084	2002	SCN5A	3	38575385	C	T
rs41311087	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38633255	C	T
rs41311117	18378609	6331	SCN5A	umls:C1142166	UNIPROT	Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation.	0.837036084	2008	SCN5A	3	38550362	A	C,G,T
rs45471994	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38613752	C	T
rs45471994	18599870	6331	SCN5A	umls:C1142166	BeFree	We characterized a novel double mutation of SCN5A (V232I in DI-S4+L1308F in DIII-S4) identified in a rare case of lidocaine (1 mg/kg)-induced Brugada syndrome.	0.837036084	2008	SCN5A	3	38613752	C	T
rs45514691	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38554345	G	A
rs45620037	14523039	6331	SCN5A	umls:C1142166	UNIPROT	Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A).	0.837036084	2003	SCN5A	3	38613787	G	A
rs45620037	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38613787	G	A
rs45627438	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38604025	C	T
rs72549410	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38606058	C	T
rs72552291	20724705	23171	GPD1L	umls:C1142166	BeFree	Rotenone, mitoTEMPO, and 4'-chlorodiazepam also blocked the mutant A280V GPD1-L (glycerol-3-phosphate dehydrogenase 1-like) effect on reducing I(Na), indicating a role for mitochondria in the Brugada syndrome caused by this mutation.	0.126448592	2010	GPD1L	3	32159096	C	T
rs72554071	20558321	3764	KCNJ8	umls:C1142166	BeFree	These findings further implicate KCNJ8 as a novel J-wave syndrome susceptibility gene and a marked gain of function in the cardiac K(ATP) Kir6.1 channel secondary to KCNJ8-S422L as a novel pathogenic mechanism for the phenotypic expression of both BrS and ERS.	0.122909916	2010	KCNJ8;LOC105369689	12	21765733	G	A
rs72554071	22056721	3764	KCNJ8	umls:C1142166	BeFree	Our results support the hypothesis that KCNJ8 is a susceptibility gene for BrS and ERS and point to S422L as a possible hotspot mutation.	0.122909916	2012	KCNJ8;LOC105369689	12	21765733	G	A
rs730880207	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38562461	C	T
rs794728852	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38609848	C	T
rs794728914	NA	6331	SCN5A	umls:C1142166	CLINVAR	NA	0.837036084	NA	SCN5A	3	38585895	AA	-
rs9388451	24667784	6336	SCN10A	umls:C1142166	BeFree	We investigated whether three single-nucleotide polymorphisms (SNPs) (rs11708996; G>C located intronic to SCN5A, rs10428132; T>G located in SCN10A, and rs9388451; T>C located downstream to HEY2) at loci associated with BrS in a recent genome-wide association study (GWAS) also were associated with AF.	0.361357209	2013	NA	6	125769231	T	C
rs9388451	24667784	6331	SCN5A	umls:C1142166	BeFree	We investigated whether three single-nucleotide polymorphisms (SNPs) (rs11708996; G>C located intronic to SCN5A, rs10428132; T>G located in SCN10A, and rs9388451; T>C located downstream to HEY2) at loci associated with BrS in a recent genome-wide association study (GWAS) also were associated with AF.	0.837036084	2013	NA	6	125769231	T	C
rs9388451	24667784	23493	HEY2	umls:C1142166	BeFree	We investigated whether three single-nucleotide polymorphisms (SNPs) (rs11708996; G>C located intronic to SCN5A, rs10428132; T>G located in SCN10A, and rs9388451; T>C located downstream to HEY2) at loci associated with BrS in a recent genome-wide association study (GWAS) also were associated with AF.	0.120542884	2013	NA	6	125769231	T	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:19)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
3	38633923	rs11708996	G	C	rs11708996	23872634	1.00E-14	NA	1.73	[1.51-1.99]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs11708996-C	Research Support, Non-U.S. Gov't	G	SCN5A
3	38648062	rs6599222	C	T	rs6599222	23872634	3.19E-04	NA	1.51	[1.21-1.89]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs6599222-T	Research Support, Non-U.S. Gov't	T	SCN5A
3	38719935	rs9851724	C	T	rs9851724	23872634	1.56E-04	NA	1.47	[1.21-1.80]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs9851724-T	Research Support, Non-U.S. Gov't	T	NA
3	38738717	rs6599240	G	A	rs6599240	23872634	1.20E-13	NA	2.07	[1.71-2.51]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs6599240-A	Research Support, Non-U.S. Gov't	G	SCN10A
3	38750375	rs11129801	A	G	rs11129801	23872634	2.77E-08	NA	2	[1.56-2.55]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs11129801-G	Research Support, Non-U.S. Gov't	A	SCN10A
3	38766675	rs6795970	A	G	rs6795970	23872634	1.11E-27	NA	2.7	[2.26-3.23]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs6795970-G	Research Support, Non-U.S. Gov't	G	SCN10A
3	38771994	rs9874633	A	G	rs9874633	23872634	1.66E-13	NA	2.7	[2.07-3.52]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs9874633-A	Research Support, Non-U.S. Gov't	G	SCN10A
3	38777554	rs10428132	T	G	rs10428132	23872634	1.00E-68	NA	2.55	[2.30-2.84]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs10428132-T	Research Support, Non-U.S. Gov't	G	SCN10A
3	38778191	rs7428167	T	C	rs7428167	23872634	1.22E-22	NA	2.86	[2.32-3.53]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs7428167-T	Research Support, Non-U.S. Gov't	C	SCN10A
3	38780059	rs10428168	T	C	rs10428168	23872634	2.36E-15	NA	2.62	[2.06-3.32]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs10428168-T	Research Support, Non-U.S. Gov't	C	SCN10A
3	38787797	rs12638572	A	G	rs12638572	23872634	2.48E-10	NA	2.12	[1.68-2.67]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs12638572-A	Research Support, Non-U.S. Gov't	G	SCN10A
3	38798836	rs6798015	C	T	rs6798015	23872634	3.53E-26	NA	2.68	[2.23-3.21]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs6798015-T	Research Support, Non-U.S. Gov't	T	SCN10A
3	38802251	rs7641844	A	G	rs7641844	23872634	3.80E-08	NA	2.02	[1.57-2.59]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs7641844-A	Research Support, Non-U.S. Gov't	A	SCN10A
3	38803639	rs7430439	G	A	rs7430439	23872634	1.10E-08	NA	1.75	[1.45-2.13]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs7430439-G	Research Support, Non-U.S. Gov't	A	SCN10A
3	38804588	rs6599257	C	T	rs6599257	23872634	1.01E-14	NA	2.17	[1.79-2.65]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs6599257-C	Research Support, Non-U.S. Gov't	T	SCN10A
6	126041164	rs1268070	C	T	rs1268070	23872634	5.13E-09	NA	1.8	[1.48-2.20]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs1268070-C	Research Support, Non-U.S. Gov't	T	NA
6	126090377	rs9388451	T	C	rs9388451	23872634	5.00E-17	NA	1.58	[1.42-1.75]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs9388451-C	Research Support, Non-U.S. Gov't	T	NA
12	114793240	rs883079	C	T	rs883079	23872634	3.97E-04	NA	1.43	[1.17-1.74]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs883079-T	Research Support, Non-U.S. Gov't	G	TBX5
12	114799974	rs7312625	G	A	rs7312625	23872634	5.46E-04	NA	1.42	[1.16-1.74]	312 European ancestry cases; 1,115 European ancestry controls	European(1427)	ALL(1427)	EUR(1427)	ALL(1427)	Brugada syndrome	HPOID:0005150	Abnormal atrioventricular conduction	DOID:0050451	Brugada syndrome	NA	NA	NA	NA	Cardiovascular disease	rs7312625-A	Research Support, Non-U.S. Gov't	G	TBX5

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:3)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C1142166	fluvoxamine	D016666	54739-18-3	brugada syndrome	MESH:D053840	marker/mechanism	19875396
C1142166	lidocaine	D008012	137-58-6	brugada syndrome	MESH:D053840	marker/mechanism	18599870
C1142166	nortriptyline	D009661	72-69-5	brugada syndrome	MESH:D053840	marker/mechanism	17089931

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)