PedAM

Pediatric Disease Annotations & Medicines


	brucellosis

Disease ID	226
Disease	brucellosis
Definition	Infection caused by bacteria of the genus BRUCELLA mainly involving the MONONUCLEAR PHAGOCYTE SYSTEM. This condition is characterized by fever, weakness, malaise, and weight loss.
Synonym	[x]brucellosis, unspecified [x]brucellosis, unspecified (disorder) brucelloses brucellosis (disorder) brucellosis [disease/finding] brucellosis due to brucella sp. brucellosis due to brucella sp. (disorder) brucellosis due to brucella species brucellosis due to brucella species (disorder) brucellosis nos brucellosis nos (disorder) brucellosis, nos brucellosis, unspecified cyprus fever cyprus fevers fever malta fever mediterranean fever, cyprus fever, gibraltar fever, malta fever, mediterranean fever, rock fever, undulant fevers, cyprus fevers, rock fevers, undulant gibraltar fever malta fever mediterranean fever melitococcosis rock fever rock fevers undulant fever undulant fevers
Orphanet	ORPHANET:1304
DOID	DOID:11077
ICD10	ICD10CM:A23.9
UMLS	C0006309
MeSH	D002006
SNOMED-CT	SNOMEDCT_US_2016_09_01:75702008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:40) C0014118 \| endocarditis \| 5 C0030312 \| pancytopenia \| 5 C0272412 \| splenic abscess \| 4 C0031046 \| pericarditis \| 3 C0040053 \| thrombosis \| 2 C0270629 \| epidural abscess \| 2 C0041296 \| tuberculosis \| 2 C0040034 \| thrombocytopenia \| 2 C0019158 \| hepatitis \| 2 C0031039 \| pericardial effusion \| 2 C0024291 \| hemophagocytic lymphohistiocytosis \| 2 C0003864 \| arthritis \| 2 C0023895 \| liver disease \| 1 C0013369 \| dysentery \| 1 C0011570 \| depression \| 1 C0021141 \| syndrome of inappropriate secretion of antidiuretic hormone \| 1 C0018378 \| guillain-barre syndrome \| 1 C0949690 \| spondyloarthritis \| 1 C0343084 \| capillary leak syndrome \| 1 C0747256 \| parasitic infection \| 1 C0155765 \| microangiopathy \| 1 C0029443 \| osteomyelitis \| 1 C0036114 \| salmonellosis \| 1 C0031039 \| pericardial effusions \| 1 C0037998 \| splenic infarction \| 1 C0025309 \| meningoencephalitis \| 1 C0038012 \| spondylitis \| 1 C0002871 \| anemia \| 1 C0024205 \| lymphadenitis \| 1 C0032285 \| pneumonia \| 1 C0034150 \| purpura \| 1 C0022660 \| acute renal failure \| 1 C0035078 \| renal failure \| 1 C0025469 \| mesenteric lymphadenitis \| 1 C0042384 \| vasculitis \| 1 C0151436 \| leukocytoclastic vasculitis \| 1 C0039103 \| synovitis \| 1 C0026986 \| myelodysplastic syndrome \| 1 C0015230 \| rash \| 1 C0012624 \| spondylodiscitis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:20) 1234 \| CCR5 \| infer 929 \| CD14 \| infer 2212 \| FCGR2A \| infer 3458 \| IFNG \| infer 3586 \| IL10 \| infer 3557 \| IL1RN \| infer 3558 \| IL2 \| infer 3565 \| IL4 \| infer 3569 \| IL6 \| infer 100507436 \| MICA \| infer 5696 \| PSMB8 \| infer 5698 \| PSMB9 \| infer 6402 \| SELL \| infer 6556 \| SLC11A1 \| infer 6890 \| TAP1 \| infer 6891 \| TAP2 \| infer 7040 \| TGFB1 \| infer 7099 \| TLR4 \| infer 7124 \| TNF \| infer 4210 \| MEFV \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:169) 7132 \| TNFRSF1A \| DISEASES 3002 \| GZMB \| DISEASES 26499 \| PLEK2 \| DISEASES 79444 \| BIRC7 \| DISEASES 64743 \| WDR13 \| DISEASES 4210 \| MEFV \| DISEASES 3191 \| HNRNPL \| DISEASES 1178 \| CLC \| DISEASES 973 \| CD79A \| DISEASES 5444 \| PON1 \| DISEASES 5118 \| PCOLCE \| DISEASES 6347 \| CCL2 \| DISEASES 51056 \| LAP3 \| DISEASES 6372 \| CXCL6 \| DISEASES 3558 \| IL2 \| DISEASES 6484 \| ST3GAL4 \| DISEASES 969 \| CD69 \| DISEASES 4598 \| MVK \| DISEASES 3458 \| IFNG \| DISEASES 80329 \| ULBP1 \| DISEASES 55856 \| ACOT13 \| DISEASES 6206 \| RPS12 \| DISEASES 4012 \| LNPEP \| DISEASES 3565 \| IL4 \| DISEASES 7903 \| ST8SIA4 \| DISEASES 27136 \| MORC1 \| DISEASES 6556 \| SLC11A1 \| DISEASES 3336 \| HSPE1 \| DISEASES 8574 \| AKR7A2 \| DISEASES 6402 \| SELL \| DISEASES 7130 \| TNFAIP6 \| DISEASES 10888 \| GPR83 \| DISEASES 5266 \| PI3 \| DISEASES 55831 \| EMC3 \| DISEASES 3659 \| IRF1 \| DISEASES 8192 \| CLPP \| DISEASES 11034 \| DSTN \| DISEASES 27352 \| SGSM3 \| DISEASES 4189 \| DNAJB9 \| DISEASES 10462 \| CLEC10A \| DISEASES 1401 \| CRP \| DISEASES 55333 \| SYNJ2BP \| DISEASES 129607 \| CMPK2 \| DISEASES 50640 \| PNPLA8 \| DISEASES 9700 \| ESPL1 \| DISEASES 23416 \| KCNH3 \| DISEASES 51455 \| REV1 \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 7097 \| TLR2 \| DISEASES 1833 \| EPYC \| DISEASES 4069 \| LYZ \| DISEASES 3074 \| HEXB \| DISEASES 4141 \| MARS \| DISEASES 5862 \| RAB2A \| DISEASES 7011 \| TEP1 \| DISEASES 5595 \| MAPK3 \| DISEASES 3553 \| IL1B \| DISEASES 3791 \| KDR \| DISEASES 9595 \| CYTIP \| DISEASES 5443 \| POMC \| DISEASES 3371 \| TNC \| DISEASES 57561 \| ARRDC3 \| DISEASES 10058 \| ABCB6 \| DISEASES 7112 \| TMPO \| DISEASES 53831 \| GPR84 \| DISEASES 4123 \| MAN2C1 \| DISEASES 150094 \| SIK1 \| DISEASES 4841 \| NONO \| DISEASES 11160 \| ERLIN2 \| DISEASES 6291 \| SAA4 \| DISEASES 3606 \| IL18 \| DISEASES 80224 \| NUBPL \| DISEASES 23420 \| NOMO1 \| DISEASES 3460 \| IFNGR2 \| DISEASES 4041 \| LRP5 \| DISEASES 151112 \| ZSWIM2 \| DISEASES 84666 \| RETNLB \| DISEASES 213 \| ALB \| DISEASES 1437 \| CSF2 \| DISEASES 5896 \| RAG1 \| DISEASES 5479 \| PPIB \| DISEASES 94274 \| PPP1R14A \| DISEASES 55630 \| SLC39A4 \| DISEASES 90864 \| SPSB3 \| DISEASES 136 \| ADORA2B \| DISEASES 7275 \| TUB \| DISEASES 8436 \| SDPR \| DISEASES 56246 \| MRAP \| DISEASES 157570 \| ESCO2 \| DISEASES 4135 \| MAP6 \| DISEASES 435 \| ASL \| DISEASES 624 \| BDKRB2 \| DISEASES 81793 \| TLR10 \| DISEASES 92369 \| SPSB4 \| DISEASES 835 \| CASP2 \| DISEASES 4281 \| MID1 \| DISEASES 6810 \| STX4 \| DISEASES 637 \| BID \| DISEASES 91662 \| NLRP12 \| DISEASES 2193 \| FARSA \| DISEASES 7791 \| ZYX \| DISEASES 284359 \| IZUMO1 \| DISEASES 23014 \| FBXO21 \| DISEASES 29933 \| GPR132 \| DISEASES 9146 \| HGS \| DISEASES 63827 \| BCAN \| DISEASES 942 \| CD86 \| DISEASES 5104 \| SERPINA5 \| DISEASES 3916 \| LAMP1 \| DISEASES 340075 \| ARSI \| DISEASES 9547 \| CXCL14 \| DISEASES 114548 \| NLRP3 \| DISEASES 3805 \| KIR2DL4 \| DISEASES 6129 \| RPL7 \| DISEASES 3329 \| HSPD1 \| DISEASES 3605 \| IL17A \| DISEASES 23764 \| MAFF \| DISEASES 3767 \| KCNJ11 \| DISEASES 6133 \| RPL9 \| DISEASES 5879 \| RAC1 \| DISEASES 6288 \| SAA1 \| DISEASES 1822 \| ATN1 \| DISEASES 10219 \| KLRG1 \| DISEASES 26136 \| TES \| DISEASES 2013 \| EMP2 \| DISEASES 6337 \| SCNN1A \| DISEASES 54106 \| TLR9 \| DISEASES 58484 \| NLRC4 \| DISEASES 9851 \| KIAA0753 \| DISEASES 9447 \| AIM2 \| DISEASES 7062 \| TCHH \| DISEASES 284486 \| THEM5 \| DISEASES 5654 \| HTRA1 \| DISEASES 80222 \| TARS2 \| DISEASES 8804 \| CREG1 \| DISEASES 959 \| CD40LG \| DISEASES 4318 \| MMP9 \| DISEASES 7417 \| VDAC2 \| DISEASES 7099 \| TLR4 \| DISEASES 100507436 \| MICA \| DISEASES 7133 \| TNFRSF1B \| DISEASES 2098 \| ESD \| DISEASES 79625 \| NDNF \| DISEASES 3559 \| IL2RA \| DISEASES 551 \| AVP \| DISEASES 283820 \| NOMO2 \| DISEASES 5888 \| RAD51 \| DISEASES 55576 \| STAB2 \| DISEASES 338442 \| HCAR2 \| DISEASES 114609 \| TIRAP \| DISEASES 23532 \| PRAME \| DISEASES 408050 \| NOMO3 \| DISEASES 27247 \| NFU1 \| DISEASES 23066 \| CAND2 \| DISEASES 57448 \| BIRC6 \| DISEASES 4125 \| MAN2B1 \| DISEASES 7124 \| TNF \| DISEASES 4615 \| MYD88 \| DISEASES 2081 \| ERN1 \| DISEASES 84978 \| FRMD5 \| DISEASES 834 \| CASP1 \| DISEASES 3586 \| IL10 \| DISEASES 8725 \| URI1 \| DISEASES 8284 \| KDM5D \| DISEASES 56899 \| ANKS1B \| DISEASES 4065 \| LY75 \| DISEASES 9051 \| PSTPIP1 \| DISEASES 10866 \| HCP5 \| DISEASES
Locus	(Waiting for update.)

Disease ID	226
Disease	brucellosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:35) HP:0001945 \| Fever \| 6 HP:0001876 \| Low blood cell count \| 5 HP:0100584 \| Endocarditis \| 4 HP:0001701 \| Pericarditis \| 3 HP:0001873 \| Low platelet count \| 2 HP:0100796 \| Orchitis \| 2 HP:0001698 \| Pericardial effusions \| 2 HP:0030005 \| Capillary leak \| 2 HP:0001824 \| Weight loss \| 2 HP:0012115 \| Liver inflammation \| 2 HP:0001369 \| Arthritis \| 2 HP:0003418 \| Back pain \| 1 HP:0001903 \| Anemia \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0001518 \| Small for gestational age \| 1 HP:0002633 \| Vasculitis \| 1 HP:0002617 \| Aneurysmal dilatation \| 1 HP:0002045 \| Abnormally low body temperature \| 1 HP:0001337 \| Tremor \| 1 HP:0010885 \| Aseptic necrosis \| 1 HP:0012531 \| Pain \| 1 HP:0002863 \| Myelodysplastic syndrome \| 1 HP:0100769 \| Synovitis \| 1 HP:0000716 \| Depression \| 1 HP:0000979 \| Purpura \| 1 HP:0002829 \| Arthralgias \| 1 HP:0030692 \| Brain tumor \| 1 HP:0000708 \| Behavioral problems \| 1 HP:0002840 \| Lymphadenitis \| 1 HP:0002625 \| Blood clot in a deep vein \| 1 HP:0012156 \| Hemophagocytosis \| 1 HP:0200119 \| Acute liver inflammation \| 1 HP:0002754 \| Bone infection \| 1 HP:0002090 \| Pneumonia \| 1 HP:0000083 \| Renal insufficiency \| 1

Disease ID	226
Disease	brucellosis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:108) C2717961 \| thrombotic microangiopathy C2711548 \| infectious process C2364133 \| infection C2186532 \| liver disease C1963211 \| pericarditis C1963083 \| cholecystitis C1961102 \| acute lymphoblastic leukemia C1735378 \| chronic polyarthritis C1611280 \| allergy C1546654 \| granuloma C1546533 \| abscess C1449646 \| primary peritonitis C1393529 \| vascular complications C1366535 \| diabetes insipidus C1328486 \| calculous cholecystitis C1320684 \| vertebral abscess C1136085 \| monoclonal gammopathy C0878631 \| pathergy C0877378 \| sacral pain C0876991 \| hemophagocytosis C0857305 \| thrombocytopenic purpura C0796095 \| c syndrome C0752303 \| urological manifestations C0751908 \| vestibular neuronitis C0751463 \| nerve root compression C0751000 \| anterior cerebral artery aneurysm C0748159 \| pulmonary involvement C0745754 \| hepatic granuloma C0743554 \| recurrent epistaxis C0598340 \| torsion spasm C0585186 \| cutaneous hypersensitivity C0574960 \| sacroiliitis C0564778 \| obstetrical disorders C0543697 \| mixed cryoglobulinemia C0497156 \| lymphadenopathy C0452221 \| spinal osteomyelitis C0422833 \| ent symptoms C0409207 \| hip arthritis C0376293 \| stigmata C0281900 \| lumbar spondylitis C0272412 \| splenic abscess C0271355 \| abducens paralysis C0267797 \| acute hepatitis C0264551 \| exudative pleural effusion C0264097 \| calcaneal apophysitis C0240111 \| knee arthritis C0239161 \| dactylitis C0235557 \| pulmonary granuloma C0235369 \| granulomatous hepatitis C0235169 \| excitability C0235031 \| neurological symptoms C0233777 \| hallucinosis C0231230 \| fatigability C0221239 \| rapidly progressive glomerulonephritis C0155288 \| papilledema C0155223 \| dacryoadenitis C0151436 \| allergic vasculitis C0149881 \| epididymoorchitis C0149881 \| epididymo-orchitis C0149871 \| deep venous thrombosis C0085435 \| reactive arthritis C0085222 \| psoas abscess C0040053 \| thrombosis C0040034 \| thrombocytopenia C0038012 \| spondylitis C0037285 \| skin manifestations C0037285 \| skin manifestation C0037284 \| skin lesions C0035435 \| rheumatism C0035304 \| retinal degenerations C0032587 \| polyradiculoneuropathy C0032541 \| polyneuritis C0031154 \| peritonitis C0031117 \| peripheral neuropathies C0030486 \| paraplegia C0030312 \| pancytopenia C0029400 \| osteitis C0029191 \| orchitis C0027765 \| nervous system diseases C0027121 \| myositis C0025311 \| meningomyelitis C0025309 \| meningoencephalitis C0024291 \| hemophagocytic syndrome C0024205 \| lymphadenitis C0023885 \| hepatic abscess C0023355 \| leptomeningitis C0022568 \| keratitis C0021141 \| syndrome of inappropriate secretion of antidiuretic hormone C0020532 \| hypersplenism C0019080 \| hemorrhage C0017658 \| glomerulonephritis C0015397 \| ocular disease C0015230 \| exanthem C0014743 \| erythema nodosum C0014583 \| episcleritis C0014118 \| endocarditis C0014038 \| encephalitis C0013504 \| hepatic hydatidosis C0012624 \| spondylodiscitis C0012624 \| discitis C0004610 \| bacteremia C0004610 \| bacteraemia C0003864 \| arthritis C0003708 \| arachnoiditis C0002878 \| hemolytic anemia C0001621 \| adrenal gland disorders C0001403 \| addison's disease C0001339 \| acute pancreatitis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:24) C0009450 \| infection \| 15 C0000833 \| abscess \| 7 C0030312 \| pancytopenia \| 5 C0014118 \| endocarditis \| 4 C0272412 \| splenic abscess \| 4 C0031046 \| pericarditis \| 3 C0029191 \| orchitis \| 2 C0003864 \| arthritis \| 2 C0040034 \| thrombocytopenia \| 2 C0040053 \| thrombosis \| 1 C0796095 \| c syndrome \| 1 C0024205 \| lymphadenitis \| 1 C0037284 \| skin lesions \| 1 C0038012 \| spondylitis \| 1 C0025309 \| meningoencephalitis \| 1 C0004610 \| bacteremia \| 1 C0574960 \| sacroiliitis \| 1 C0012624 \| spondylodiscitis \| 1 C0422833 \| ent symptoms \| 1 C2717961 \| thrombotic microangiopathy \| 1 C0876991 \| hemophagocytosis \| 1 C0023895 \| liver disease \| 1 C0748159 \| pulmonary involvement \| 1 C0267797 \| acute hepatitis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:6)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1131498	16585636	6402	SELL	umls:C0006309	BeFree	Association between the Phe206Leu polymorphism of L-selectin and brucellosis.	0.005362824	2006	SELL	1	169707345	A	G
rs11466023	25318808	4210	MEFV	umls:C0006309	BeFree	Mediterranean fever (MEFV) variant P369S/R408Q in a patient with entero-Behçet's disease who successfully responded to treatment with colchicine.	0.008881637	2015	MEFV	16	3249586	G	T,A
rs11466024	25318808	4210	MEFV	umls:C0006309	BeFree	Mediterranean fever (MEFV) variant P369S/R408Q in a patient with entero-Behçet's disease who successfully responded to treatment with colchicine.	0.008881637	2015	MEFV	16	3249468	C	T
rs2476601	19107641	26191	PTPN22	umls:C0006309	BeFree	PTPN22 C1858T polymorphism and human brucellosis.	0.002638474	2009	PTPN22;AP4B1-AS1	1	113834946	A	G
rs3743930	21210266	4210	MEFV	umls:C0006309	BeFree	Genetic analysis was done and heterozygous mutation E148Q was detected as a disease-causing Mediterranean fever (MEFV) mutation.	0.008881637	2011	MEFV	16	3254626	C	G
rs386580517	16585636	6402	SELL	umls:C0006309	BeFree	Association between the Phe206Leu polymorphism of L-selectin and brucellosis.	0.005362824	2006	NA	NA	NA	NA	NA

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0006309	rifampin	D012293	13292-46-1	brucellosis	MESH:D002006	therapeutic	16236685

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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