PedAM
Pediatric Disease Annotations & Medicines
| bronchitis | ||||
| Disease ID | 859 |
|---|---|
| Disease | bronchitis |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:5) C0010200 | cough | 28 C0037199 | sinusitis | 4 C1145670 | respiratory failure | 2 C0422833 | ent symptoms | 1 C0038826 | superinfection | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:3) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs2227983 | 23551418 | 1956 | EGFR | umls:C0006277 | BeFree | A novel association between bronchitis and a non-synonymous functional ERBB1 SNP, rs2227983 (aka epidermal growth factor receptor:R497K, R521K) is also reported and evidence presented of interaction between MUC5AC and ERBB1 and between MUC5AC and IL1RN with respect to bronchitis. | 0.000271442 | 2013 | EGFR | 7 | 55161562 | G | A,C,T |
| rs2227983 | 23551418 | 4586 | MUC5AC | umls:C0006277 | BeFree | A novel association between bronchitis and a non-synonymous functional ERBB1 SNP, rs2227983 (aka epidermal growth factor receptor:R497K, R521K) is also reported and evidence presented of interaction between MUC5AC and ERBB1 and between MUC5AC and IL1RN with respect to bronchitis. | 0.000271442 | 2013 | EGFR | 7 | 55161562 | G | A,C,T |
| rs2227983 | 23551418 | 3557 | IL1RN | umls:C0006277 | BeFree | A novel association between bronchitis and a non-synonymous functional ERBB1 SNP, rs2227983 (aka epidermal growth factor receptor:R497K, R521K) is also reported and evidence presented of interaction between MUC5AC and ERBB1 and between MUC5AC and IL1RN with respect to bronchitis. | 0.000271442 | 2013 | EGFR | 7 | 55161562 | G | A,C,T |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:1) | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CHR | POS | SNPID | REF | ALT | ORI_SNPID | PMID | P_VALUE | P_VALUE_TEXT | OR/BETA | CI95_TEXT | GWAS_INITIAL_SAMPLE_SIZE | SUB_POPULATION | SUPER_POPULATION | GWAS_TRAIT | HPO_ID | HPO_TERM | DO_ID | DO_TERM | MESH_ID | MESH_TERM | EFO_ID | EFO_TERM | DOLITE_TERM | RISK_ALLELE | PUBLICATION_TYPE | AA | GENE_SYMBOL | TYPE | REFGENE |
| 3 | 18397849 | rs6577641 | C | T | rs6577641 | 24714607 | 4.00E-06 | NA | 1.17 | NA | 717 European ancestry cases; 2,385 European ancestry controls | European(3102) | ALL(3102) | EUR(3102) | ALL(3102) | Chronic mucus hypersecretion | HPOID:0004469 | Chronic bronchitis | DOID:6132 | bronchitis | NA | NA | NA | NA | NA | rs6577641-G | Research Support, N.I.H., Extramural | Meta-Analysis | Research Support, Non-U.S. Gov't |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:4) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0006277 | doxycycline | D004318 | 564-25-0 | bronchitis | MESH:D001991 | therapeutic | 9004058 | ||
| C0006277 | enoxacin | D015365 | 74011-58-8 | bronchitis | MESH:D001991 | therapeutic | 3258863 | ||
| C0006277 | ofloxacin | D015242 | 82419-36-1 | bronchitis | MESH:D001991 | therapeutic | 10388331 | ||
| C0006277 | theophylline | D013806 | 58-55-9 | bronchitis | MESH:D001991 | therapeutic | 3025113 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |