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Pediatric Disease Annotations & Medicines



   bronchiolitis obliterans
  

Disease ID 574
Disease bronchiolitis obliterans
Definition
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
Synonym
bronchiolitis obliterans [disease/finding]
bronchiolitis obliterative
ob - obliterative bronchiolitis
obliterative bonchiolitis
obliterative bronchiolitis
obliterative bronchiolitis (disorder)
obliterative bronchiolitis, nos
DOID
UMLS
C0006272
MeSH
SNOMED-CT
Comorbidity
UMLS | Disease | Sentences' Count(Total Sentences:34)
C0032285  |  pneumonia  |  35
C1145670  |  respiratory failure  |  4
C0038325  |  stevens-johnson syndrome  |  3
C0020538  |  hypertension  |  2
C0020542  |  pulmonary hypertension  |  2
C0006267  |  bronchiectasis  |  2
C0006271  |  bronchiolitis  |  2
C0004623  |  bacterial infections  |  2
C0004623  |  bacterial infection  |  2
C0030807  |  pemphigus  |  2
C0034050  |  pulmonary alveolar proteinosis  |  1
C0017168  |  gastroesophageal reflux disease  |  1
C0035435  |  rheumatic diseases  |  1
C0006272  |  obliterative bronchiolitis  |  1
C0006277  |  bronchitis  |  1
C0221757  |  alpha-1 antitrypsin deficiency  |  1
C0001430  |  adenoma  |  1
C0035229  |  respiratory insufficiency  |  1
C0024537  |  benign tertian malaria  |  1
C0009324  |  ulcerative colitis  |  1
C0017168  |  acid reflux  |  1
C0034069  |  pulmonary fibrosis  |  1
C0010414  |  cryptococcus neoformans  |  1
C0018801  |  heart failure  |  1
C0017168  |  esophageal reflux disease  |  1
C0024115  |  lung disease  |  1
C1800706  |  idiopathic pulmonary fibrosis  |  1
C0032326  |  pneumothorax  |  1
C0242770  |  cryptogenic organizing pneumonia  |  1
C0024117  |  chronic obstructive pulmonary disease (copd)  |  1
C0035435  |  rheumatic disease  |  1
C0042769  |  virus infection  |  1
C0032285  |  pulmonary inflammation  |  1
C0009319  |  colitis  |  1
Curated Gene
Entrez_id | Symbol | Resource(Total Genes:1)
IFNG  |  3458  |  CTD_human
Inferring Gene
Entrez_id | Symbol | Resource(Total Genes:11)
4316  |  MMP7  |  infer
7096  |  TLR1  |  infer
81793  |  TLR10  |  infer
7097  |  TLR2  |  infer
7098  |  TLR3  |  infer
7099  |  TLR4  |  infer
7100  |  TLR5  |  infer
10333  |  TLR6  |  infer
51284  |  TLR7  |  infer
51311  |  TLR8  |  infer
54106  |  TLR9  |  infer
Text Mined Gene
Entrez_id | Symbol | Score | Resource(Total Genes:184)
84957  |  RELT  |  DISEASES
5704  |  PSMC4  |  DISEASES
22846  |  VASH1  |  DISEASES
3861  |  KRT14  |  DISEASES
3162  |  HMOX1  |  DISEASES
158  |  ADSL  |  DISEASES
3002  |  GZMB  |  DISEASES
623  |  BDKRB1  |  DISEASES
7076  |  TIMP1  |  DISEASES
4313  |  MMP2  |  DISEASES
6367  |  CCL22  |  DISEASES
7040  |  TGFB1  |  DISEASES
973  |  CD79A  |  DISEASES
828  |  CAPS  |  DISEASES
858  |  CAV2  |  DISEASES
4353  |  MPO  |  DISEASES
6347  |  CCL2  |  DISEASES
3558  |  IL2  |  DISEASES
2251  |  FGF6  |  DISEASES
55801  |  IL26  |  DISEASES
3458  |  IFNG  |  DISEASES
2597  |  GAPDH  |  DISEASES
3565  |  IL4  |  DISEASES
3554  |  IL1R1  |  DISEASES
566  |  AZU1  |  DISEASES
5657  |  PRTN3  |  DISEASES
4317  |  MMP8  |  DISEASES
5273  |  SERPINB10  |  DISEASES
3215  |  HOXB5  |  DISEASES
4360  |  MRC1  |  DISEASES
10804  |  GJB6  |  DISEASES
667  |  DST  |  DISEASES
8139  |  GAN  |  DISEASES
968  |  CD68  |  DISEASES
6351  |  CCL4  |  DISEASES
6320  |  CLEC11A  |  DISEASES
55902  |  ACSS2  |  DISEASES
1401  |  CRP  |  DISEASES
1116  |  CHI3L1  |  DISEASES
1830  |  DSG3  |  DISEASES
1828  |  DSG1  |  DISEASES
3569  |  IL6  |  DISEASES
64005  |  MYO1G  |  DISEASES
4316  |  MMP7  |  DISEASES
6521  |  SLC4A1  |  DISEASES
2294  |  FOXF1  |  DISEASES
25939  |  SAMHD1  |  DISEASES
10133  |  OPTN  |  DISEASES
22858  |  ICK  |  DISEASES
3682  |  ITGAE  |  DISEASES
23523  |  CABIN1  |  DISEASES
3552  |  IL1A  |  DISEASES
3553  |  IL1B  |  DISEASES
1991  |  ELANE  |  DISEASES
4072  |  EPCAM  |  DISEASES
3574  |  IL7  |  DISEASES
943  |  TNFRSF8  |  DISEASES
941  |  CD80  |  DISEASES
56925  |  LXN  |  DISEASES
59067  |  IL21  |  DISEASES
2247  |  FGF2  |  DISEASES
6774  |  STAT3  |  DISEASES
3383  |  ICAM1  |  DISEASES
1462  |  VCAN  |  DISEASES
3578  |  IL9  |  DISEASES
6291  |  SAA4  |  DISEASES
7356  |  SCGB1A1  |  DISEASES
740  |  MRPL49  |  DISEASES
166785  |  MMAA  |  DISEASES
7547  |  ZIC3  |  DISEASES
123803  |  NTAN1  |  DISEASES
5993  |  RFX5  |  DISEASES
4489  |  MT1A  |  DISEASES
729230  |  CCR2  |  DISEASES
6352  |  CCL5  |  DISEASES
6368  |  CCL23  |  DISEASES
213  |  ALB  |  DISEASES
6374  |  CXCL5  |  DISEASES
3600  |  IL15  |  DISEASES
6059  |  ABCE1  |  DISEASES
4724  |  NDUFS4  |  DISEASES
1437  |  CSF2  |  DISEASES
5896  |  RAG1  |  DISEASES
144568  |  A2ML1  |  DISEASES
2125  |  EVPL  |  DISEASES
6356  |  CCL11  |  DISEASES
6037  |  RNASE3  |  DISEASES
1673  |  DEFB4A  |  DISEASES
1493  |  CTLA4  |  DISEASES
171558  |  PTCRA  |  DISEASES
3596  |  IL13  |  DISEASES
3627  |  CXCL10  |  DISEASES
3575  |  IL7R  |  DISEASES
6373  |  CXCL11  |  DISEASES
126669  |  SHE  |  DISEASES
1241  |  LTB4R  |  DISEASES
624  |  BDKRB2  |  DISEASES
81793  |  TLR10  |  DISEASES
947  |  CD34  |  DISEASES
92745  |  SLC38A5  |  DISEASES
4179  |  CD46  |  DISEASES
1909  |  EDNRA  |  DISEASES
8685  |  MARCO  |  DISEASES
29851  |  ICOS  |  DISEASES
3579  |  CXCR2  |  DISEASES
5339  |  PLEC  |  DISEASES
3309  |  HSPA5  |  DISEASES
64327  |  LMBR1  |  DISEASES
2318  |  FLNC  |  DISEASES
633  |  BGN  |  DISEASES
7050  |  TGIF1  |  DISEASES
64806  |  IL25  |  DISEASES
4990  |  SIX6  |  DISEASES
5155  |  PDGFB  |  DISEASES
942  |  CD86  |  DISEASES
4088  |  SMAD3  |  DISEASES
135  |  ADORA2A  |  DISEASES
10376  |  TUBA1B  |  DISEASES
857  |  CAV1  |  DISEASES
5493  |  PPL  |  DISEASES
1308  |  COL17A1  |  DISEASES
54345  |  SOX18  |  DISEASES
6590  |  SLPI  |  DISEASES
3605  |  IL17A  |  DISEASES
6275  |  S100A4  |  DISEASES
5154  |  PDGFA  |  DISEASES
3683  |  ITGAL  |  DISEASES
987  |  LRBA  |  DISEASES
1902  |  LPAR1  |  DISEASES
3135  |  HLA-G  |  DISEASES
1825  |  DSC3  |  DISEASES
2475  |  MTOR  |  DISEASES
4283  |  CXCL9  |  DISEASES
84072  |  HORMAD1  |  DISEASES
9937  |  DCLRE1A  |  DISEASES
2058  |  EPRS  |  DISEASES
5788  |  PTPRC  |  DISEASES
1490  |  CTGF  |  DISEASES
4582  |  MUC1  |  DISEASES
5550  |  PREP  |  DISEASES
8732  |  RNGTT  |  DISEASES
23566  |  LPAR3  |  DISEASES
959  |  CD40LG  |  DISEASES
7422  |  VEGFA  |  DISEASES
6441  |  SFTPD  |  DISEASES
4318  |  MMP9  |  DISEASES
5453  |  POU3F1  |  DISEASES
64900  |  LPIN3  |  DISEASES
2833  |  CXCR3  |  DISEASES
3561  |  IL2RG  |  DISEASES
1896  |  EDA  |  DISEASES
7581  |  ZNF33A  |  DISEASES
50943  |  FOXP3  |  DISEASES
100507436  |  MICA  |  DISEASES
3105  |  HLA-A  |  DISEASES
3604  |  TNFRSF9  |  DISEASES
6354  |  CCL7  |  DISEASES
1906  |  EDN1  |  DISEASES
1832  |  DSP  |  DISEASES
94  |  ACVRL1  |  DISEASES
11202  |  KLK8  |  DISEASES
6439  |  SFTPB  |  DISEASES
51520  |  LARS  |  DISEASES
79924  |  ADM2  |  DISEASES
2919  |  CXCL1  |  DISEASES
6387  |  CXCL12  |  DISEASES
655  |  BMP7  |  DISEASES
8341  |  HIST1H2BN  |  DISEASES
100134934  |  TEN1  |  DISEASES
23308  |  ICOSLG  |  DISEASES
7852  |  CXCR4  |  DISEASES
23066  |  CAND2  |  DISEASES
3113  |  HLA-DPA1  |  DISEASES
3702  |  ITK  |  DISEASES
7124  |  TNF  |  DISEASES
3106  |  HLA-B  |  DISEASES
3586  |  IL10  |  DISEASES
51428  |  DDX41  |  DISEASES
2994  |  GYPB  |  DISEASES
83481  |  EPPK1  |  DISEASES
727897  |  MUC5B  |  DISEASES
930  |  CD19  |  DISEASES
8284  |  KDM5D  |  DISEASES
100128731  |  OST4  |  DISEASES
Locus(Waiting for update.)
Disease ID 574
Disease bronchiolitis obliterans
Integrated Phenotype(Waiting for update.)
Text Mined Phenotype
HPO | Name | Sentences' Count(Total Phenotypes:21)
HP:0002090  |  Pneumonia  |  35
HP:0011945  |  Cryptogenic organizing pneumonia  |  7
HP:0002878  |  Respiratory failure  |  4
HP:0002092  |  Pulmonary artery hypertension  |  2
HP:0011950  |  Bronchiolitis  |  2
HP:0000822  |  Hypertension  |  2
HP:0002093  |  progressive respiratory failure  |  2
HP:0002110  |  Bronchiectasis  |  2
HP:0011947  |  Respiratory infection  |  1
HP:0002020  |  Heartburn  |  1
HP:0002206  |  Pulmonary fibrosis  |  1
HP:0002583  |  Colitis  |  1
HP:0002107  |  Collapsed lung  |  1
HP:0001482  |  Subcutaneous nodule  |  1
HP:0100582  |  Nasal polyps  |  1
HP:0002955  |  Granulomatosis  |  1
HP:0100279  |  Ulcerative colitis  |  1
HP:0001635  |  Congestive heart failure  |  1
HP:0012387  |  Bronchitis  |  1
HP:0012416  |  Hypercarbia  |  1
HP:0100750  |  Pulmonary atelectasis  |  1
Disease ID 574
Disease bronchiolitis obliterans
Manually Symptom
UMLS  | Name(Total Manually Symptoms:11)
C2697391  |  rheumatoid arthritis
C2350763  |  unilateral hyperlucent lung
C1963220  |  pulmonary hypertension
C1145670  |  respiratory failure
C1112570  |  paraneoplastic pemphigus
C0334303  |  alveolar adenoma
C0264492  |  chronic respiratory failure
C0231819  |  air trapping
C0017168  |  gastroesophageal reflux disease
C0017168  |  gastroesophageal reflux
C0009782  |  connective tissue disease
Text Mined Symptom
UMLS | Name | Sentences' Count(Total Symptoms:6)
Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)
All Snps(Total Genotypes:0)
(Waiting for update.)
GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)
GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)
Mapped by lexical matching(Total Items:0)
(Waiting for update.)
Mapped by homologous gene(Total Items:0)
(Waiting for update.)
Chemical(Total Drugs:0)
(Waiting for update.)
FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)
FDA labeling changes(Total Drugs:0)
(Waiting for update.)