PedAM
Pediatric Disease Annotations & Medicines
| bronchiolitis | ||||
| Disease ID | 1224 |
|---|---|
| Disease | bronchiolitis |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:9) C0043144 | wheezing | 13 C1145670 | respiratory failure | 12 C0476273 | respiratory distress | 6 C0264490 | acute respiratory failure | 2 C0001883 | airway obstruction | 2 C0035229 | respiratory insufficiency | 2 C0042769 | virus infection | 2 C0043144 | wheeze | 1 C0037090 | respiratory symptoms | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:27) | |||||||||||||
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| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs1060826 | 17703412 | 4843 | NOS2 | umls:C0006271 | BeFree | SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. | 0.000542884 | 2007 | NOS2 | 17 | 27762841 | T | C |
| rs1060826 | 17703412 | 7421 | VDR | umls:C0006271 | BeFree | SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. | 0.002638474 | 2007 | NOS2 | 17 | 27762841 | T | C |
| rs1060826 | 17703412 | 3725 | JUN | umls:C0006271 | BeFree | SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. | 0.000542884 | 2007 | NOS2 | 17 | 27762841 | T | C |
| rs1060826 | 17703412 | 3442 | IFNA5 | umls:C0006271 | BeFree | SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. | 0.000271442 | 2007 | NOS2 | 17 | 27762841 | T | C |
| rs10735810 | 17703412 | 4843 | NOS2 | umls:C0006271 | BeFree | SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. | 0.000542884 | 2007 | NA | NA | NA | NA | NA |
| rs10735810 | 17703412 | 3442 | IFNA5 | umls:C0006271 | BeFree | SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. | 0.000271442 | 2007 | NA | NA | NA | NA | NA |
| rs10735810 | 17703412 | 3725 | JUN | umls:C0006271 | BeFree | SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. | 0.000542884 | 2007 | NA | NA | NA | NA | NA |
| rs10735810 | 17703412 | 7421 | VDR | umls:C0006271 | BeFree | SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. | 0.002638474 | 2007 | NA | NA | NA | NA | NA |
| rs10757212 | 17703412 | 3725 | JUN | umls:C0006271 | BeFree | SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. | 0.000542884 | 2007 | IFNA5 | 9 | 21304804 | G | A |
| rs10757212 | 17703412 | 7421 | VDR | umls:C0006271 | BeFree | SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. | 0.002638474 | 2007 | IFNA5 | 9 | 21304804 | G | A |
| rs10757212 | 17703412 | 4843 | NOS2 | umls:C0006271 | BeFree | SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. | 0.000542884 | 2007 | IFNA5 | 9 | 21304804 | G | A |
| rs10757212 | 17703412 | 3442 | IFNA5 | umls:C0006271 | BeFree | SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. | 0.000271442 | 2007 | IFNA5 | 9 | 21304804 | G | A |
| rs11688 | 17703412 | 4843 | NOS2 | umls:C0006271 | BeFree | SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. | 0.000542884 | 2007 | JUN | 1 | 58782321 | C | T |
| rs11688 | 17703412 | 3442 | IFNA5 | umls:C0006271 | BeFree | SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. | 0.000271442 | 2007 | JUN | 1 | 58782321 | C | T |
| rs11688 | 17703412 | 3725 | JUN | umls:C0006271 | BeFree | SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. | 0.000542884 | 2007 | JUN | 1 | 58782321 | C | T |
| rs11688 | 17703412 | 7421 | VDR | umls:C0006271 | BeFree | SNPs in the innate immune genes VDR (rs10735810; P=.0017), JUN (rs11688; P=.0093), IFNA5 (rs10757212; P=.0093), and NOS2 (rs1060826; P=.0031) demonstrated the strongest association with bronchiolitis. | 0.002638474 | 2007 | JUN | 1 | 58782321 | C | T |
| rs1799724 | 18811622 | 4049 | LTA | umls:C0006271 | BeFree | The following study populations were genotyped for 4 polymorphisms within TNF-beta (rs909253) and TNF-alpha (rs1799964, rs1799724, rs1800629): 322 asthmatic children, 151 children with severe respiratory syncytial virus (RSV) bronchiolitis and 270 controls. | 0.000271442 | 2009 | LTA;TNF | 6 | 31574705 | C | T |
| rs1799964 | 18811622 | 4049 | LTA | umls:C0006271 | BeFree | The following study populations were genotyped for 4 polymorphisms within TNF-beta (rs909253) and TNF-alpha (rs1799964, rs1799724, rs1800629): 322 asthmatic children, 151 children with severe respiratory syncytial virus (RSV) bronchiolitis and 270 controls. | 0.000271442 | 2009 | LTA;TNF;LOC100287329 | 6 | 31574531 | T | C |
| rs1800629 | 18811622 | 4049 | LTA | umls:C0006271 | BeFree | The following study populations were genotyped for 4 polymorphisms within TNF-beta (rs909253) and TNF-alpha (rs1799964, rs1799724, rs1800629): 322 asthmatic children, 151 children with severe respiratory syncytial virus (RSV) bronchiolitis and 270 controls. | 0.000271442 | 2009 | TNF | 6 | 31575254 | G | A |
| rs1800896 | 24167151 | 3606 | IL18 | umls:C0006271 | BeFree | IL10 rs1800896, IFNG rs2430561, and IL18 rs1872387 polymorphims and their associations with asthma and allergy were studied in 135 preschool-aged children hospitalized for bronchiolitis at age 0-6 months. | 0.002995792 | 2013 | IL10 | 1 | 206773552 | T | C |
| rs1800896 | 24167151 | 3586 | IL10 | umls:C0006271 | BeFree | Polymorphism of the rs1800896 IL10 promoter gene protects children from post-bronchiolitis asthma. | 0.001357209 | 2013 | IL10 | 1 | 206773552 | T | C |
| rs1872387 | 24167151 | 3606 | IL18 | umls:C0006271 | BeFree | IL10 rs1800896, IFNG rs2430561, and IL18 rs1872387 polymorphims and their associations with asthma and allergy were studied in 135 preschool-aged children hospitalized for bronchiolitis at age 0-6 months. | 0.002995792 | 2013 | LOC105373640 | 2 | 138964859 | G | C |
| rs2069885 | 20503287 | 3578 | IL9 | umls:C0006271 | BeFree | In conclusion, the IL-9 genetic polymorphism (rs2069885) has an opposite effect on the risk of severe RSV bronchiolitis in boys and girls. | 0.000814326 | 2010 | IL9 | 5 | 135892476 | G | A |
| rs2430561 | 24167151 | 3606 | IL18 | umls:C0006271 | BeFree | IL10 rs1800896, IFNG rs2430561, and IL18 rs1872387 polymorphims and their associations with asthma and allergy were studied in 135 preschool-aged children hospitalized for bronchiolitis at age 0-6 months. | 0.002995792 | 2013 | IFNG | 12 | 68158742 | T | A |
| rs386586050 | 22549436 | 7098 | TLR3 | umls:C0006271 | BeFree | Toll-like receptor 3 L412F polymorphisms in infants with bronchiolitis and postbronchiolitis wheezing. | 0.000271442 | 2012 | NA | NA | NA | NA | NA |
| rs5743618 | 24445834 | 7096 | TLR1 | umls:C0006271 | BeFree | In this study, we demonstrated that TLR1 rs5743618 was associated with asthma and atopic eczema during the first 6 years of life after early bronchiolitis. | 0.000271442 | 2014 | TLR1 | 4 | 38797027 | C | A |
| rs909253 | 18811622 | 4049 | LTA | umls:C0006271 | BeFree | The following study populations were genotyped for 4 polymorphisms within TNF-beta (rs909253) and TNF-alpha (rs1799964, rs1799724, rs1800629): 322 asthmatic children, 151 children with severe respiratory syncytial virus (RSV) bronchiolitis and 270 controls. | 0.000271442 | 2009 | LTA;LOC100287329 | 6 | 31572536 | A | G |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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Chemical(Total Drugs:0) | |
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FDA approved drug and dosage information(Total Drugs:0) | |
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FDA labeling changes(Total Drugs:0) | |
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