PedAM

Pediatric Disease Annotations & Medicines


	botulism

Disease ID	932
Disease	botulism
Definition	A disease caused by potent protein NEUROTOXINS produced by CLOSTRIDIUM BOTULINUM which interfere with the presynaptic release of ACETYLCHOLINE at the NEUROMUSCULAR JUNCTION. Clinical features include abdominal pain, vomiting, acute PARALYSIS (including respiratory paralysis), blurred vision, and DIPLOPIA. Botulism may be classified into several subtypes (e.g., food-borne, infant, wound, and others). (From Adams et al., Principles of Neurology, 6th ed, p1208)
Synonym	botulism (disorder) botulism [disease/finding] botulism nos botulism toxico infect botulism, toxico infectious botulism, toxico-infectious botulisms infection caused by clostridium botulinum infection caused by clostridium botulinum (disorder) infection due to clostridium botulinum infection due to clostridium botulinum (disorder) intoxication with clostridium botulinum toxin intoxication with clostridium botulinum toxin (disorder) toxico infect botulism toxico infectious botulism toxico-infectious botulism
Orphanet	ORPHANET:1267
DOID	DOID:11976
UMLS	C0006057
MeSH	D001906
SNOMED-CT	SNOMEDCT_US_2016_09_01:398565003;SNOMEDCT_US_2016_09_01:414531002
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:5) C0029089 \| ophthalmoplegia \| 1 C0010678 \| cysticercosis \| 1 C0027868 \| neuromuscular diseases \| 1 C0026848 \| muscular diseases \| 1 C0027868 \| neuromuscular disease \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:84) 9341 \| VAMP3 \| DISEASES 112755 \| STX1B \| DISEASES 9524 \| TECR \| DISEASES 2999 \| GZMH \| DISEASES 7991 \| TUSC3 \| DISEASES 973 \| CD79A \| DISEASES 3036 \| HAS1 \| DISEASES 6804 \| STX1A \| DISEASES 8288 \| EPX \| DISEASES 29915 \| HCFC2 \| DISEASES 8161 \| COIL \| DISEASES 7291 \| TWIST1 \| DISEASES 55821 \| ALLC \| DISEASES 2161 \| F12 \| DISEASES 5914 \| RARA \| DISEASES 6616 \| SNAP25 \| DISEASES 4836 \| NMT1 \| DISEASES 1101 \| CHAD \| DISEASES 6857 \| SYT1 \| DISEASES 999 \| CDH1 \| DISEASES 3938 \| LCT \| DISEASES 84162 \| KIAA1109 \| DISEASES 25824 \| PRDX5 \| DISEASES 2044 \| EPHA5 \| DISEASES 23643 \| LY96 \| DISEASES 10563 \| CXCL13 \| DISEASES 55687 \| TRMU \| DISEASES 115825 \| WDFY2 \| DISEASES 51282 \| SCAND1 \| DISEASES 29071 \| C1GALT1C1 \| DISEASES 8019 \| BRD3 \| DISEASES 80124 \| VCPIP1 \| DISEASES 6844 \| VAMP2 \| DISEASES 6810 \| STX4 \| DISEASES 8411 \| EEA1 \| DISEASES 788 \| SLC25A20 \| DISEASES 9899 \| SV2B \| DISEASES 682 \| BSG \| DISEASES 10732 \| TCFL5 \| DISEASES 327657 \| SERPINA9 \| DISEASES 5078 \| PAX4 \| DISEASES 126364 \| LRRC25 \| DISEASES 25870 \| SUMF2 \| DISEASES 5348 \| FXYD1 \| DISEASES 9218 \| VAPA \| DISEASES 1798 \| DPAGT1 \| DISEASES 7080 \| NKX2-1 \| DISEASES 10438 \| C1D \| DISEASES 83658 \| DYNLRB1 \| DISEASES 5169 \| ENPP3 \| DISEASES 2571 \| GAD1 \| DISEASES 51592 \| TRIM33 \| DISEASES 56980 \| PRDM10 \| DISEASES 51150 \| SDF4 \| DISEASES 127833 \| SYT2 \| DISEASES 1660 \| DHX9 \| DISEASES 10223 \| GPA33 \| DISEASES 262 \| AMD1 \| DISEASES 9900 \| SV2A \| DISEASES 55118 \| CRTAC1 \| DISEASES 6812 \| STXBP1 \| DISEASES 26190 \| FBXW2 \| DISEASES 4593 \| MUSK \| DISEASES 7295 \| TXN \| DISEASES 7454 \| WAS \| DISEASES 6520 \| SLC3A2 \| DISEASES 5251 \| PHEX \| DISEASES 4093 \| SMAD9 \| DISEASES 2813 \| GP2 \| DISEASES 7247 \| TSN \| DISEASES 5077 \| PAX3 \| DISEASES 1621 \| DBH \| DISEASES 6843 \| VAMP1 \| DISEASES 4905 \| NSF \| DISEASES 8671 \| SLC4A4 \| DISEASES 25821 \| MTO1 \| DISEASES 2900 \| GRIK4 \| DISEASES 9498 \| SLC4A8 \| DISEASES 54475 \| NLE1 \| DISEASES 51428 \| DDX41 \| DISEASES 22987 \| SV2C \| DISEASES 246734 \| NPCDR1 \| DISEASES 102723508 \| KANTR \| DISEASES 378938 \| MALAT1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	932
Disease	botulism
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:18) HP:0011675 \| Arrhythmia HP:0000217 \| Xerostomia HP:0100021 \| Cerebral palsy HP:0000016 \| Urinary retention HP:0010547 \| Muscle flaccidity HP:0012378 \| Fatigue HP:0002015 \| Dysphagia HP:0002019 \| Constipation HP:0006824 \| Cranial nerve paralysis HP:0002014 \| Diarrhea HP:0011499 \| Mydriasis HP:0002017 \| Nausea and vomiting HP:0000651 \| Diplopia HP:0002093 \| Respiratory insufficiency HP:0002027 \| Abdominal pain HP:0009113 \| Diaphragmatic weakness HP:0001260 \| Dysarthria HP:0006597 \| Diaphragmatic paralysis
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:8) HP:0003470 \| Inability to move \| 3 HP:0002015 \| Swallowing difficulty \| 2 HP:0001945 \| Fever \| 1 HP:0002380 \| Muscle twitch \| 1 HP:0003324 \| Muscle weakness, diffuse \| 1 HP:0000602 \| Ophthalmoplegia \| 1 HP:0012531 \| Pain \| 1 HP:0011096 \| Demyelination \| 1

Disease ID	932
Disease	botulism
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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