PedAM

Pediatric Disease Annotations & Medicines


	autonomic dysfunction

Disease ID	1302
Disease	autonomic dysfunction
Definition	Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
Synonym	ans (autonomic nervous system) diseases ans dis ans disease ans diseases autonomic central nervous system diseases autonomic cns dis autonomic dis autonomic disease autonomic disease nervous system autonomic diseases autonomic diseases nervous system autonomic disorder autonomic disorders autonomic disorders nervous system autonomic nerve dis nec autonomic nervous disorders autonomic nervous disorders: nonspecific autonomic nervous system dis autonomic nervous system diseases autonomic nervous system diseases [disease/finding] autonomic nervous system disorder autonomic nervous system disorder nos autonomic nervous system disorder nos (disorder) autonomic nervous system disorders autonomic nervous system--diseases central autonomic nervous system dis central autonomic nervous system diseases dis autonomic nervous system disease ans disease autonomic diseases ans disorder of autonomic nervous system disorder of autonomic nervous system (disorder) disorder of autonomic nervous system, nos disorder of vegetative system disorder of vegetative system, nos disorders of autonomic nervous system disorders of the autonomic nervous system nervous system dis autonomic nervous system diseases, autonomic unspecified disorder of autonomic nervous system
DOID	DOID:11465
UMLS	C1145628
MeSH	D001342
SNOMED-CT	SNOMEDCT_US_2016_09_01:15241006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:148) C0011847 \| diabetes \| 21 C0030567 \| parkinson's disease \| 12 C0011860 \| type 2 diabetes \| 10 C0011849 \| diabetes mellitus \| 10 C0026769 \| multiple sclerosis \| 9 C0152025 \| polyneuropathy \| 5 C0037315 \| sleep apnea \| 4 C0011854 \| type 1 diabetes \| 4 C0036341 \| schizophrenia \| 4 C0030567 \| parkinson disease \| 4 C0020538 \| hypertension \| 4 C0039614 \| tetanus \| 3 C0014544 \| epilepsy \| 3 C0023890 \| cirrhosis \| 3 C0442874 \| neuropathy \| 3 C0409974 \| lupus erythematosus \| 3 C0011860 \| type 2 diabetes mellitus \| 3 C0017601 \| glaucoma \| 3 C0497327 \| dementia \| 3 C0520679 \| obstructive sleep apnea \| 2 C0242350 \| impotence \| 2 C0024115 \| pulmonary disease \| 2 C0031117 \| peripheral neuropathy \| 2 C0032460 \| polycystic ovary \| 2 C0018799 \| heart disease \| 2 C0006625 \| cachectic \| 2 C0040188 \| tic disorders \| 2 C0018801 \| heart failure \| 2 C0024117 \| chronic obstructive pulmonary disease (copd) \| 2 C0024117 \| chronic obstructive pulmonary disease \| 2 C0004134 \| ataxia \| 2 C0032460 \| polycystic ovary syndrome \| 2 C0001519 \| holmes-adie syndrome \| 2 C0009806 \| constipation \| 2 C0020456 \| hyperglycemia \| 2 C0036202 \| sarcoidosis \| 2 C0085580 \| essential hypertension \| 2 C0152136 \| normal tension glaucoma \| 2 C0016053 \| fibromyalgia \| 2 C0001519 \| adie syndrome \| 2 C0023890 \| liver cirrhosis \| 2 C0393571 \| multiple system atrophy \| 2 C0011882 \| diabetic neuropathy \| 2 C0036421 \| systemic sclerosis \| 2 C0041234 \| chagas disease \| 2 C0752347 \| dementia with lewy bodies \| 2 C0600260 \| obstructive pulmonary disease \| 2 C0011854 \| diabetes mellitus type 1 \| 2 C0024141 \| systemic lupus erythematosus \| 2 C0010068 \| coronary artery disease \| 1 C0019196 \| hepatitis c \| 1 C0002871 \| anemia \| 1 C0458219 \| complex regional pain syndrome \| 1 C0007758 \| cerebellar ataxia \| 1 C0006625 \| cachexia \| 1 C0017168 \| esophageal reflux \| 1 C0042373 \| vascular disease \| 1 C0003125 \| anorexia nervosa \| 1 C0152078 \| pelvic pain syndrome \| 1 C0023895 \| liver disorders \| 1 C0029089 \| ophthalmoplegia \| 1 C0017168 \| esophageal reflux disease \| 1 C0271742 \| allgrove syndrome \| 1 C0162316 \| iron deficiency anemia \| 1 C0041948 \| uremia \| 1 C0007222 \| cardiovascular disease \| 1 C0020456 \| hyperglycaemia \| 1 C0035455 \| rhinitis \| 1 C0520679 \| obstructive sleep apnea syndrome \| 1 C0037315 \| sleep disordered breathing \| 1 C0948265 \| metabolic syndrome \| 1 C1527336 \| sjogren's syndrome \| 1 C0042373 \| vascular diseases \| 1 C1258215 \| ileus \| 1 C0011991 \| diarrhea \| 1 C0037769 \| west syndrome \| 1 C0022658 \| renal disease \| 1 C0014544 \| epileptic seizure \| 1 C0020538 \| vascular hypertension \| 1 C0002986 \| fabry disease \| 1 C0003873 \| rheumatoid arthritis \| 1 C0017168 \| oesophageal reflux \| 1 C0017168 \| gastroesophageal reflux \| 1 C0019158 \| hepatitis \| 1 C0024408 \| machado-joseph disease \| 1 C2607914 \| allergic rhinitis \| 1 C0037315 \| sleep apnea syndrome \| 1 C0001206 \| acromegaly \| 1 C0349788 \| arrhythmogenic right ventricular cardiomyopathy \| 1 C0520680 \| central sleep apnea \| 1 C0027765 \| neurological disorders \| 1 C1306557 \| chronic venous insufficiency \| 1 C0011570 \| depression \| 1 C0022661 \| end-stage renal failure \| 1 C0020545 \| renovascular hypertension \| 1 C0042485 \| venous insufficiency \| 1 C0851578 \| sleep disorders \| 1 C0022661 \| chronic kidney disease \| 1 C0017168 \| gastroesophageal reflux disease \| 1 C0037928 \| spinal cord disease \| 1 C0002395 \| alzheimer's disease \| 1 C0017605 \| angle closure glaucoma \| 1 C0024299 \| lymphoma \| 1 C0004352 \| autism \| 1 C0085278 \| antiphospholipid syndrome \| 1 C0026848 \| myopathy \| 1 C0030446 \| paralytic ileus \| 1 C0002895 \| sickle cell anemia \| 1 C0154946 \| acute angle closure glaucoma \| 1 C0003872 \| psoriatic arthritis \| 1 C0023895 \| liver disorder \| 1 C0393819 \| chronic inflammatory demyelinating polyradiculoneuropathy \| 1 C0679466 \| cognitive deficits \| 1 C0042075 \| urological disorders \| 1 C0271680 \| diabetic polyneuropathy \| 1 C0155502 \| benign paroxysmal positional vertigo \| 1 C0024408 \| joseph disease \| 1 C0036439 \| scoliosis \| 1 C0524851 \| neurodegenerative disease \| 1 C0314719 \| dry eye \| 1 C0003028 \| anhidrosis \| 1 C0027765 \| neurological disorder \| 1 C0018378 \| guillain-barre syndrome \| 1 C0024523 \| malabsorption \| 1 C0022116 \| ischemia \| 1 C0314719 \| dry eyes \| 1 C0149931 \| migraine \| 1 C0259749 \| autonomic neuropathy \| 1 C0002895 \| sickle cell anaemia \| 1 C0014544 \| epileptic seizures \| 1 C0009319 \| colitis \| 1 C0004943 \| behcet disease \| 1 C0005745 \| ptosis \| 1 C0032285 \| pneumonia \| 1 C0037928 \| myelopathy \| 1 C0014804 \| erythromelalgia \| 1 C0035078 \| renal failure \| 1 C0034372 \| quadriplegia \| 1 C0028754 \| obesity \| 1 C1145670 \| respiratory failure \| 1 C0238052 \| cerebrotendinous xanthomatosis \| 1 C0007222 \| cardiovascular diseases \| 1 C0026850 \| muscular dystrophy \| 1 C0020179 \| huntington's disease \| 1 C0033953 \| sexual dysfunction \| 1 C0159069 \| impaired glucose tolerance \| 1 C1142166 \| brugada syndrome \| 1 C0011854 \| type 1 diabetes mellitus \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) ECE1 \| 1889 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 1621 \| DBH \| infer
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1302
Disease	autonomic dysfunction
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:114) HP:0000819 \| Diabetes mellitus \| 10 HP:0002615 \| Low blood pressure \| 6 HP:0011675 \| Arrhythmias \| 6 HP:0012531 \| Pain \| 5 HP:0001271 \| Polyneuropathy \| 5 HP:0001649 \| Tachycardia \| 5 HP:0010535 \| Sleep apnea \| 4 HP:0001300 \| Parkinsonism \| 4 HP:0002104 \| Absence of spontaneous respiration \| 4 HP:0100753 \| Schizophrenia \| 4 HP:0002140 \| Ischemic stroke \| 4 HP:0001297 \| Cerebral vascular events \| 4 HP:0000822 \| Hypertension \| 4 HP:0001394 \| Hepatic cirrhosis \| 3 HP:0100315 \| Lewy bodies \| 3 HP:0000501 \| Glaucoma \| 3 HP:0001279 \| Syncope \| 3 HP:0001251 \| Ataxia \| 3 HP:0000726 \| Dementia \| 3 HP:0100543 \| Cognitive deficits \| 3 HP:0010783 \| Erythema \| 2 HP:0001250 \| Seizures \| 2 HP:0002019 \| Dyschezia \| 2 HP:0005110 \| Atrial fibrillation \| 2 HP:0001324 \| Muscular weakness \| 2 HP:0002725 \| Systemic lupus erythematosus \| 2 HP:0003074 \| High blood glucose \| 2 HP:0002870 \| Obstructive sleep apnea \| 2 HP:0000970 \| Lack of sweating \| 2 HP:0100033 \| Tic disorder \| 2 HP:0000147 \| Sclerocystic ovaries \| 2 HP:0009830 \| Peripheral neuritis \| 2 HP:0000802 \| Erectile dysfunction \| 2 HP:0001278 \| Orthostatic hypotension \| 2 HP:0100806 \| Sepsis \| 2 HP:0001635 \| Congestive heart failure \| 2 HP:0012173 \| Postural tachycardia \| 2 HP:0006510 \| Chronic obstructive pulmonary disease \| 2 HP:0002597 \| Abnormality of blood vessels \| 1 HP:0001337 \| Tremor \| 1 HP:0002527 \| Falls \| 1 HP:0001587 \| Primary ovarian insufficiency \| 1 HP:0000602 \| Ophthalmoplegia \| 1 HP:0001382 \| Hyperextensible joints \| 1 HP:0012384 \| Nasal inflammation \| 1 HP:0100817 \| Renovascular hypertension \| 1 HP:0002747 \| Respiratory distress due to muscle weakness \| 1 HP:0002196 \| Myelopathy \| 1 HP:0004757 \| Paroxysmal atrial fibrillation \| 1 HP:0003193 \| Allergic rhinitis \| 1 HP:0002583 \| Colitis \| 1 HP:0001945 \| Fever \| 1 HP:0001662 \| Bradycardia \| 1 HP:0005943 \| Respiratory arrest \| 1 HP:0007256 \| Abnormal pyramidal signs \| 1 HP:0001284 \| Areflexia \| 1 HP:0010536 \| Central sleep apnoea \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0002665 \| Lymphoma \| 1 HP:0012668 \| Situational syncope \| 1 HP:0002445 \| Paralysis of all four limbs \| 1 HP:0003560 \| Muscular dystrophy \| 1 HP:0003701 \| Proximal limb muscle weakness \| 1 HP:0002590 \| Paralytic ileus \| 1 HP:0000717 \| Autism \| 1 HP:0002448 \| Progressive encephalopathy \| 1 HP:0000958 \| Xerosis \| 1 HP:0004326 \| Cachexia \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0001513 \| Obesity \| 1 HP:0005293 \| Venous insufficiency \| 1 HP:0004756 \| Ventricular tachycardia \| 1 HP:0002273 \| Tetraparesis \| 1 HP:0002315 \| Headaches \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0001891 \| Iron-deficiency anemia \| 1 HP:0001041 \| Blushing \| 1 HP:0012378 \| Fatigue \| 1 HP:0001677 \| Coronary artery disease \| 1 HP:0004409 \| Decreased smell sensation \| 1 HP:0002076 \| Migraine headaches \| 1 HP:0002878 \| Respiratory failure \| 1 HP:0011663 \| Cardiomyopathy, right ventricular \| 1 HP:0002039 \| Anorexia \| 1 HP:0002020 \| Heartburn \| 1 HP:0012622 \| Chronic kidney disease \| 1 HP:0001097 \| Keratoconjunctivitis sicca \| 1 HP:0002090 \| Pneumonia \| 1 HP:0003198 \| Myopathic changes \| 1 HP:0012743 \| Central obesity \| 1 HP:0002063 \| Muscle rigidity \| 1 HP:0000508 \| Drooping upper eyelid \| 1 HP:0000020 \| Bladder incontinence \| 1 HP:0002650 \| Scoliosis \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0004755 \| Supraventricular tachycardia \| 1 HP:0007942 \| Internal ophthalmoplegia \| 1 HP:0001903 \| Anemia \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0012532 \| Chronic pain \| 1 HP:0000845 \| Acromegalic growth \| 1 HP:0002071 \| Extrapyramidal dysfunction \| 1 HP:0003326 \| Muscle pain \| 1 HP:0002014 \| Diarrhea \| 1 HP:0002024 \| Intestinal malabsorption \| 1 HP:0007178 \| Motor polyneuropathy \| 1 HP:0000833 \| Glucose intolerance \| 1 HP:0030914 \| Abnormal peristalsis \| 1 HP:0000716 \| Depression \| 1 HP:0001695 \| Cardiac arrest \| 1 HP:0002321 \| Vertigo \| 1 HP:0002595 \| Gastrointestinal atony \| 1 HP:0000217 \| Dry mouth syndrome \| 1

Disease ID	1302
Disease	autonomic dysfunction
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs121918126	12805287	6530	SLC6A2	umls:C1145628	BeFree	Recently, our laboratory reported a polymorphism in the human NET (hNET) gene A457P in an individual with the autonomic disorder orthostatic intolerance (OI).	0.000271442	2003	SLC6A2	16	55698005	G	A,C,T
rs3811647	25457201	3077	HFE	umls:C1145628	BeFree	Because these two outcomes were clearly associated with the biochemical and clinical expression of the disease, an indirect link between the rs3811647 polymorphism and the phenotypic presentation of HFE-HH is likely.	0.000271442	2014	TF	3	133765185	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:20)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C1145628	alprazolam	D000525	28981-97-7	autonomic nervous system diseases	MESH:D001342	marker/mechanism	10389047
C1145628	amitriptyline	D000639	50-48-6	autonomic nervous system diseases	MESH:D001342	marker/mechanism	7862922
C1145628	atenolol	D001262	29122-68-7	autonomic nervous system diseases	MESH:D001342	therapeutic	11794720
C1145628	bleomycin	D001761	11056-06-7	autonomic nervous system diseases	MESH:D001342	marker/mechanism	1690581
C1145628	chlorpromazine	D002746	50-53-3	autonomic nervous system diseases	MESH:D001342	marker/mechanism	6662980
C1145628	citalopram	D015283	59729-33-8	autonomic nervous system diseases	MESH:D001342	marker/mechanism	12691792
C1145628	clonidine	D003000	4205-90-7	autonomic nervous system diseases	MESH:D001342	marker/mechanism	8821553
C1145628	clonidine	D003000	4205-90-7	autonomic nervous system diseases	MESH:D001342	therapeutic	7030751
C1145628	clozapine	D003024	5786-21-0	autonomic nervous system diseases	MESH:D001342	marker/mechanism	11483480
C1145628	cisplatin	D002945	15663-27-1	autonomic nervous system diseases	MESH:D001342	marker/mechanism	1690581
C1145628	droperidol	D004329	548-73-2	autonomic nervous system diseases	MESH:D001342	marker/mechanism	11406684
C1145628	gemcitabine	C056507	103882-84-4	autonomic nervous system diseases	MESH:D001342	marker/mechanism	9500323
C1145628	minoxidil	D008914	38304-91-5	autonomic nervous system diseases	MESH:D001342	marker/mechanism	7030751
C1145628	peginterferon alfa-2b	C417083	-	autonomic nervous system diseases	MESH:D001342	marker/mechanism	19047844
C1145628	prazosin	D011224	19216-56-9	autonomic nervous system diseases	MESH:D001342	therapeutic	8821553
C1145628	propranolol	D011433	525-66-6	autonomic nervous system diseases	MESH:D001342	therapeutic	11794720
C1145628	ribavirin	D012254	36791-04-5	autonomic nervous system diseases	MESH:D001342	marker/mechanism	19047844
C1145628	vinblastine	D014747	865-21-4	autonomic nervous system diseases	MESH:D001342	marker/mechanism	1329697
C1145628	vincristine	D014750	-	autonomic nervous system diseases	MESH:D001342	marker/mechanism	1329697
C1145628	vinorelbine	C030852	71486-22-1	autonomic nervous system diseases	MESH:D001342	marker/mechanism	11325488

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)