PedAM

Pediatric Disease Annotations & Medicines


	autoimmune hemolytic anemia

Disease ID	227
Disease	autoimmune hemolytic anemia
Definition	Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.
Synonym	aiha - autoimmune haemolytic anaemia aiha - autoimmune hemolytic anemia anaemia haemolytic autoimmune anemia autoimmune hemolytic anemia hemolytic autoimmune anemia hemolytic autoimmune (nos) anemia, autoimmune hemolytic anemia, hemolytic, autoimmune anemia, hemolytic, autoimmune [disease/finding] anemias, autoimmune hemolytic autoimmun hemolytic anem autoimmune haemolytic anaemia autoimmune haemolytic anaemia (disorder) autoimmune haemolytic anaemia nos autoimmune haemolytic anaemias autoimmune hemolytic anemia (disorder) autoimmune hemolytic anemia nos autoimmune hemolytic anemia nos (disorder) autoimmune hemolytic anemia, nos autoimmune hemolytic anemias haemolytic anaemia due to antibody hemolytic anemia due to antibody hemolytic anemia due to antibody, nos hemolytic anemia, autoimmune hemolytic anemias, autoimmune hemolytic autoimmune anemia immunohemolytic anemia
Orphanet	ORPHANET:98375
OMIM	OMIM:205700
DOID	DOID:718
UMLS	C0002880
MeSH	D000744
SNOMED-CT	SNOMEDCT_US_2016_09_01:413603009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:76) C0019158 \| hepatitis \| 12 C0023448 \| lymphocytic leukemia \| 6 C0024299 \| lymphoma \| 5 C0023434 \| chronic lymphocytic leukemia \| 5 C0023418 \| leukemia \| 5 C0040034 \| thrombocytopenia \| 3 C0034150 \| purpura \| 3 C0026764 \| multiple myeloma \| 3 C0024141 \| systemic lupus erythematosus \| 3 C0272286 \| immune thrombocytopenia \| 3 C0008313 \| sclerosing cholangitis \| 2 C0272126 \| evans syndrome \| 2 C0085278 \| antiphospholipid syndrome \| 2 C0026986 \| myelodysplastic syndrome \| 2 C0026764 \| myeloma \| 2 C0409974 \| lupus erythematosus \| 2 C0034902 \| pure red cell aplasia \| 2 C0019196 \| hepatitis c \| 2 C0009324 \| ulcerative colitis \| 2 C0039730 \| thalassemia \| 2 C0032285 \| pneumonia \| 2 C0024302 \| large cell lymphoma \| 1 C0042769 \| virus infection \| 1 C0085642 \| livedo reticularis \| 1 C0012236 \| digeorge syndrome \| 1 C0041296 \| tuberculosis \| 1 C0032285 \| pneumoniae \| 1 C0235974 \| pancreatic cancer \| 1 C0012739 \| disseminated intravascular coagulation \| 1 C1266119 \| solitary fibrous tumor \| 1 C0024790 \| paroxysmal nocturnal hemoglobinuria \| 1 C0026691 \| kawasaki disease \| 1 C0019829 \| hodgkin lymphoma \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0040381 \| tolosa-hunt syndrome \| 1 C0010346 \| crohn's disease \| 1 C0037998 \| splenic infarction \| 1 C0023890 \| liver cirrhosis \| 1 C1140680 \| ovarian cancer \| 1 C0349632 \| splenic marginal zone lymphoma \| 1 C0040100 \| thymoma \| 1 C0026934 \| mycoplasma \| 1 C0024314 \| lymphoproliferative disorder \| 1 C0085786 \| idiopathic interstitial pneumonia \| 1 C0009319 \| colitis \| 1 C0001339 \| acute pancreatitis \| 1 C0023890 \| cirrhosis \| 1 C0023486 \| prolymphocytic leukemia \| 1 C0002871 \| anemia \| 1 C0043117 \| idiopathic thrombocytopenic purpura \| 1 C0041316 \| tuberculous lymphadenitis \| 1 C0024314 \| lymphoproliferative disorders \| 1 C0008311 \| cholangitis \| 1 C1140680 \| ovarian ca \| 1 C0027873 \| neuromyelitis optica \| 1 C0004135 \| ataxia telangiectasia \| 1 C0281963 \| red cell aplasia \| 1 C0241910 \| autoimmune hepatitis \| 1 C1527336 \| sjogren's syndrome \| 1 C0030305 \| pancreatitis \| 1 C0025289 \| meningitis \| 1 C0024305 \| non-hodgkin lymphoma \| 1 C0028242 \| nocardiosis \| 1 C0021053 \| immune disease \| 1 C0019163 \| hepatitis b \| 1 C0023449 \| acute lymphoblastic leukemia \| 1 C0004134 \| ataxia \| 1 C0032302 \| mycoplasma pneumonia \| 1 C0566602 \| primary sclerosing cholangitis \| 1 C0019069 \| hemophilia \| 1 C0242584 \| autoimmune thrombocytopenia \| 1 C0022672 \| acute tubular necrosis \| 1 C0043117 \| immune thrombocytopenic purpura \| 1 C0008728 \| churg-strauss syndrome \| 1 C0085273 \| parvovirus b19 infection \| 1 C0085436 \| cryptococcal meningitis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) SLC14A1 \| 6563 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:129) 933 \| CD22 \| DISEASES 7066 \| THPO \| DISEASES 350 \| APOH \| DISEASES 6948 \| TCN2 \| DISEASES 973 \| CD79A \| DISEASES 727 \| C5 \| DISEASES 952 \| CD38 \| DISEASES 3558 \| IL2 \| DISEASES 969 \| CD69 \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 718 \| C3 \| DISEASES 4695 \| NDUFA2 \| DISEASES 27112 \| FAM155B \| DISEASES 684 \| BST2 \| DISEASES 2056 \| EPO \| DISEASES 2694 \| GIF \| DISEASES 6926 \| TBX3 \| DISEASES 3569 \| IL6 \| DISEASES 1101 \| CHAD \| DISEASES 2995 \| GYPC \| DISEASES 109 \| ADCY3 \| DISEASES 10113 \| PREB \| DISEASES 7450 \| VWF \| DISEASES 9172 \| MYOM2 \| DISEASES 1716 \| DGUOK \| DISEASES 3938 \| LCT \| DISEASES 941 \| CD80 \| DISEASES 1356 \| CP \| DISEASES 7535 \| ZAP70 \| DISEASES 26277 \| TINF2 \| DISEASES 6647 \| SOD1 \| DISEASES 9869 \| SETDB1 \| DISEASES 6567 \| SLC16A2 \| DISEASES 710 \| SERPING1 \| DISEASES 5205 \| ATP8B1 \| DISEASES 10 \| NAT2 \| DISEASES 27163 \| NAAA \| DISEASES 2207 \| FCER1G \| DISEASES 3889 \| KRT83 \| DISEASES 6006 \| RHCE \| DISEASES 2215 \| FCGR3B \| DISEASES 213 \| ALB \| DISEASES 5896 \| RAG1 \| DISEASES 915 \| CD3D \| DISEASES 6786 \| STIM1 \| DISEASES 51082 \| POLR1D \| DISEASES 1493 \| CTLA4 \| DISEASES 4247 \| MGAT2 \| DISEASES 2147 \| F2 \| DISEASES 5897 \| RAG2 \| DISEASES 947 \| CD34 \| DISEASES 56945 \| MRPS22 \| DISEASES 1776 \| DNASE1L3 \| DISEASES 1604 \| CD55 \| DISEASES 4684 \| NCAM1 \| DISEASES 165829 \| GPR156 \| DISEASES 7485 \| WRB \| DISEASES 716 \| C1S \| DISEASES 29933 \| GPR132 \| DISEASES 6007 \| RHD \| DISEASES 3043 \| HBB \| DISEASES 2152 \| F3 \| DISEASES 966 \| CD59 \| DISEASES 921 \| CD5 \| DISEASES 9577 \| BRE \| DISEASES 3605 \| IL17A \| DISEASES 2035 \| EPB41 \| DISEASES 3767 \| KCNJ11 \| DISEASES 3792 \| KEL \| DISEASES 355 \| FAS \| DISEASES 3240 \| HP \| DISEASES 140885 \| SIRPA \| DISEASES 219844 \| HYLS1 \| DISEASES 3981 \| LIG4 \| DISEASES 987 \| LRBA \| DISEASES 2213 \| FCGR2B \| DISEASES 7037 \| TFRC \| DISEASES 2157 \| F8 \| DISEASES 2993 \| GYPA \| DISEASES 84061 \| MAGT1 \| DISEASES 961 \| CD47 \| DISEASES 6905 \| TBCE \| DISEASES 1378 \| CR1 \| DISEASES 10090 \| UST \| DISEASES 356 \| FASLG \| DISEASES 1805 \| DPT \| DISEASES 55811 \| ADCY10 \| DISEASES 2214 \| FCGR3A \| DISEASES 4720 \| NDUFS2 \| DISEASES 2209 \| FCGR1A \| DISEASES 914 \| CD2 \| DISEASES 8517 \| IKBKG \| DISEASES 959 \| CD40LG \| DISEASES 1718 \| DHCR24 \| DISEASES 5203 \| PFDN4 \| DISEASES 11093 \| ADAMTS13 \| DISEASES 100 \| ADA \| DISEASES 1043 \| CD52 \| DISEASES 10673 \| TNFSF13B \| DISEASES 50943 \| FOXP3 \| DISEASES 1041 \| CDSN \| DISEASES 7454 \| WAS \| DISEASES 54790 \| TET2 \| DISEASES 3440 \| IFNA2 \| DISEASES 3456 \| IFNB1 \| DISEASES 5277 \| PIGA \| DISEASES 83650 \| SLC35G5 \| DISEASES 974 \| CD79B \| DISEASES 2643 \| GCH1 \| DISEASES 23077 \| MYCBP2 \| DISEASES 4435 \| CITED1 \| DISEASES 1438 \| CSF2RA \| DISEASES 7124 \| TNF \| DISEASES 3612 \| IMPA1 \| DISEASES 3586 \| IL10 \| DISEASES 10046 \| MAMLD1 \| DISEASES 721 \| C4B \| DISEASES 51428 \| DDX41 \| DISEASES 2533 \| FYB \| DISEASES 9788 \| MTSS1 \| DISEASES 917 \| CD3G \| DISEASES 1207 \| CLNS1A \| DISEASES 930 \| CD19 \| DISEASES 51499 \| TRIAP1 \| DISEASES 56963 \| RGMA \| DISEASES 567 \| B2M \| DISEASES 7732 \| RNF112 \| DISEASES 388588 \| SMIM1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	227
Disease	autoimmune hemolytic anemia
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:18) HP:0001881 \| Abnormality of leukocytes HP:0001945 \| Fever HP:0002665 \| Lymphoma HP:0011675 \| Arrhythmia HP:0001939 \| Laboratory abnormality HP:0002094 \| Dyspnea HP:0000980 \| Pallor HP:0001635 \| Congestive heart failure HP:0012086 \| Abnormal urinary color HP:0002315 \| Headache HP:0012378 \| Fatigue HP:0001324 \| Muscle weakness HP:0001744 \| Splenomegaly HP:0001890 \| Autoimmune hemolytic anemia HP:0002721 \| Immunodeficiency HP:0002027 \| Abdominal pain HP:0002960 \| Autoimmunity HP:0001878 \| Hemolytic anemia
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:41) HP:0012115 \| Liver inflammation \| 12 HP:0200084 \| Giant cell hepatitis \| 8 HP:0005550 \| Chronic lymphatic leukemia \| 4 HP:0000979 \| Purpura \| 3 HP:0001973 \| Autoimmune thrombocytopenia \| 3 HP:0001909 \| Leukemia \| 3 HP:0001873 \| Low platelet count \| 3 HP:0006775 \| Multiple myeloma \| 3 HP:0002665 \| Lymphoma \| 3 HP:0012410 \| Pure red cell aplasia \| 2 HP:0100279 \| Ulcerative colitis \| 2 HP:0002725 \| Systemic lupus erythematosus \| 2 HP:0100280 \| Morbus Crohn \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0002090 \| Pneumonia \| 1 HP:0100522 \| Thymoma \| 1 HP:0004818 \| Paroxysmal nocturnal hemoglobinuria \| 1 HP:0002664 \| Neoplasia \| 1 HP:0005521 \| Disseminated intravascular coagulation \| 1 HP:0200119 \| Acute liver inflammation \| 1 HP:0001394 \| Hepatic cirrhosis \| 1 HP:0001903 \| Anemia \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0012539 \| Non-Hodgkin lymphoma \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0001251 \| Ataxia \| 1 HP:0030151 \| Cholangitis \| 1 HP:0002583 \| Colitis \| 1 HP:0001945 \| Fever \| 1 HP:0001735 \| Acute pancreatitis \| 1 HP:0002863 \| Myelodysplastic syndrome \| 1 HP:0009726 \| Renal neoplasm \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0001287 \| Meningitis \| 1 HP:0002894 \| Neoplasia of the pancreas \| 1 HP:0000965 \| Livedo reticularis \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0100523 \| Hepatic abscess \| 1 HP:0008682 \| Renal tubular necrosis \| 1 HP:0012190 \| T cell lymphoma \| 1

Disease ID	227
Disease	autoimmune hemolytic anemia
Manually Symptom	UMLS \| Name(Total Manually Symptoms:43) C2697391 \| rheumatoid arthritis C2697310 \| sarcoidosis C1963220 \| pulmonary hypertension C1962966 \| retinopathy C1956158 \| ventricular septal perforation C1744558 \| t cell deficiency C1112746 \| primary hepatic lymphoma C1096584 \| chlamydia pneumoniae infection C1000587 \| pemphigus C0919267 \| ovarian neoplasm C0876998 \| intracardiac thrombus C0751340 \| ocular myasthenia gravis C0740302 \| 5q- syndrome C0349632 \| splenic marginal zone lymphoma C0271072 \| retinal phlebitis C0268379 \| cholinesterase deficiency C0241910 \| autoimmune hepatitis C0152025 \| polyneuropathy C0086438 \| hypogammaglobulinemia C0079744 \| diffuse large cell lymphoma C0079744 \| diffuse large b-cell lymphoma C0037116 \| silicosis C0030809 \| pemphigus vulgaris C0030186 \| extramammary paget's disease C0027765 \| neurologic disorders C0027697 \| nephritis C0026946 \| mycoses C0026896 \| myasthenia gravis C0026764 \| multiple myeloma C0024314 \| lymphoproliferative disorders C0024305 \| non-hodgkin's lymphoma C0024299 \| malignant lymphoma C0024141 \| systemic lupus erythematosus C0023434 \| b cell lymphocytic leukemia C0023418 \| leukemia C0020981 \| angioimmunoblastic lymphadenopathy with dysproteinemia C0020550 \| hyperthyroidism C0019080 \| hemorrhage C0014059 \| acute disseminated encephalomyelitis C0009324 \| ulcerative colitis C0008313 \| sclerosing cholangitis C0008312 \| primary biliary cirrhosis C0002892 \| pernicious anemia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:8) C0026764 \| multiple myeloma \| 3 C0023418 \| leukemia \| 3 C0009324 \| ulcerative colitis \| 2 C0008313 \| sclerosing cholangitis \| 2 C0024141 \| systemic lupus erythematosus \| 2 C0024314 \| lymphoproliferative disorders \| 1 C0349632 \| splenic marginal zone lymphoma \| 1 C0241910 \| autoimmune hepatitis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:31)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0002880	carbimazole	D002231	22232-54-8	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	3377989
C0002880	cladribine	D017338	4291-63-8	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	10721776
C0002880	chlorpromazine	D002746	50-53-3	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	55680
C0002880	cimetidine	D002927	51481-61-9	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	89583
C0002880	ciprofloxacin	D002939	85721-33-1	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	12841809
C0002880	cyclophosphamide	D003520	50-18-0	anemia, hemolytic, autoimmune	MESH:D000744	therapeutic	16595573
C0002880	cyclosporine	D016572	59865-13-3	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	3286357
C0002880	cyclosporine	D016572	59865-13-3	anemia, hemolytic, autoimmune	MESH:D000744	therapeutic	8405335
C0002880	dapsone	D003622	80-08-0	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	1471153
C0002880	cisplatin	D002945	15663-27-1	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	7795280
C0002880	diclofenac	D004008	15307-86-5	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	11642029
C0002880	diltiazem	D004110	42399-41-7	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	9207477
C0002880	fenoprofen	D005279	31879-05-7	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	3348176
C0002880	fluorouracil	D005472	51-21-8	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	3567089
C0002880	folic acid	D005492	59-30-3	anemia, hemolytic, autoimmune	MESH:D000744	therapeutic	5694067
C0002880	lenalidomide	C467567	-	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	17158529
C0002880	mefloquine	D015767	53230-10-7	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	9426652
C0002880	methotrexate	D008727	1959/5/2	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	11021173
C0002880	nafcillin	D009254	147-52-4	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	6176609
C0002880	ofloxacin	D015242	82419-36-1	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	12841809
C0002880	omeprazole	D009853	73590-58-6	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	9695674
C0002880	peginterferon alfa-2a	C100416	-	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	16785129
C0002880	phenytoin	D010672	57-41-0	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	9404778
C0002880	piperacillin	D010878	61477-96-1	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	12366773
C0002880	piroxicam	D010894	36322-90-4	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	3354087
C0002880	ribavirin	D012254	36791-04-5	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	18200424
C0002880	sulindac	D013467	38194-50-2	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	4026480
C0002880	thiopental	D013874	76-75-5	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	3969087
C0002880	tolmetin	D014046	26171-23-3	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	2773031
C0002880	triamterene	D014223	396-01-0	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	493878
C0002880	valproic acid	D014635	99-66-1	anemia, hemolytic, autoimmune	MESH:D000744	marker/mechanism	15717181

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
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